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Aliases for KRT39 Gene

Aliases for KRT39 Gene

  • Keratin 39 2 3
  • Keratin 39, Type I 2 3 5
  • Cytokeratin-39 3 4
  • Keratin-39 3 4
  • CK-39 3 4
  • KA35 3 4
  • K39 3 4
  • Type I Hair Keratin KA35 3
  • Type I Hair Keratin Ka35 4

External Ids for KRT39 Gene

Previous GeneCards Identifiers for KRT39 Gene

  • GC17M036369
  • GC17M039114
  • GC17M034909

Summaries for KRT39 Gene

Entrez Gene Summary for KRT39 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT39 Gene

KRT39 (Keratin 39) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

UniProtKB/Swiss-Prot for KRT39 Gene

  • May play a role in late hair differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT39 Gene

Genomics for KRT39 Gene

Regulatory Elements for KRT39 Gene

Enhancers for KRT39 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT39 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT39 Gene

40,958,417 bp from pter
40,966,892 bp from pter
8,476 bases
Minus strand

Genomic View for KRT39 Gene

Genes around KRT39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT39 Gene

Proteins for KRT39 Gene

  • Protein details for KRT39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 39
    Protein Accession:
    Secondary Accessions:
    • B2RXK6
    • Q6IFU6

    Protein attributes for KRT39 Gene

    491 amino acids
    Molecular mass:
    55651 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT39 Gene

Proteomics data for KRT39 Gene at MOPED

Post-translational modifications for KRT39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT39 Gene

Domains & Families for KRT39 Gene

Gene Families for KRT39 Gene

Protein Domains for KRT39 Gene

Suggested Antigen Peptide Sequences for KRT39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT39: view

Function for KRT39 Gene

Molecular function for KRT39 Gene

UniProtKB/Swiss-Prot Function:
May play a role in late hair differentiation.
genes like me logo Genes that share phenotypes with KRT39: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT39 Gene

Localization for KRT39 Gene

Subcellular locations from

Jensen Localization Image for KRT39 Gene COMPARTMENTS Subcellular localization image for KRT39 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRT39 Gene

Pathways & Interactions for KRT39 Gene

SuperPathways for KRT39 Gene

No Data Available

Interacting Proteins for KRT39 Gene

Gene Ontology (GO) - Biological Process for KRT39 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT39 Gene

Drugs & Compounds for KRT39 Gene

No Compound Related Data Available

Transcripts for KRT39 Gene

mRNA/cDNA for KRT39 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT39 Gene

Keratin 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT39 Gene

No ASD Table

Relevant External Links for KRT39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT39 Gene

mRNA expression in normal human tissues for KRT39 Gene

mRNA differential expression in normal tissues according to GTEx for KRT39 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.2) and Skin - Sun Exposed (Lower leg) (x6.2).

Protein differential expression in normal tissues from HIPED for KRT39 Gene

This gene is overexpressed in Hair follicle (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT39 Gene

SOURCE GeneReport for Unigene cluster for KRT39 Gene Hs.28467

mRNA Expression by UniProt/SwissProt for KRT39 Gene

Tissue specificity: Expressed in skin and scalp. In the hair follicle, it is present in the upper hair cuticle and the upper cortex. Also present in the in the upper portion of beard hairs (at protein level).
genes like me logo Genes that share expression patterns with KRT39: view

Protein tissue co-expression partners for KRT39 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRT39 Gene

Orthologs for KRT39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT39 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT39 35
  • 83.23 (n)
  • 76.17 (a)
KRT39 36
  • 76 (a)
(Canis familiaris)
Mammalia KRT39 35
  • 83.51 (n)
  • 77.13 (a)
KRT39 36
  • 77 (a)
(Mus musculus)
Mammalia Krt39 35
  • 79.86 (n)
  • 74.79 (a)
Krt39 16
Krt39 36
  • 74 (a)
(Pan troglodytes)
Mammalia KRT39 35
  • 99.19 (n)
  • 98.57 (a)
KRT39 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt39 35
  • 79.9 (n)
  • 75.05 (a)
(Monodelphis domestica)
Mammalia KRT39 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia KRT39 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
-- 36
  • 49 (a)
(Danio rerio)
Actinopterygii BX469912.1 36
  • 19 (a)
cyt1 36
  • 38 (a)
cyt1l 36
  • 38 (a)
krt1-19d 36
  • 35 (a)
krt15 36
  • 33 (a)
krt17 36
  • 37 (a)
si:dkeyp-113d7.4 36
  • 32 (a)
wu:fb17f05 36
  • 37 (a)
zgc:109868 36
  • 38 (a)
zgc:136902 36
  • 34 (a)
zgc:153629 36
  • 35 (a)
zgc:92035 36
  • 34 (a)
zgc:92061 36
  • 37 (a)
zgc:92533 36
  • 19 (a)
Species with no ortholog for KRT39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT39 Gene

Gene Tree for KRT39 (if available)
Gene Tree for KRT39 (if available)

Paralogs for KRT39 Gene

genes like me logo Genes that share paralogs with KRT39: view

Variants for KRT39 Gene

Sequence variations from dbSNP and Humsavar for KRT39 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_038075 -
VAR_038076 -
VAR_038077 -

Structural Variations from Database of Genomic Variants (DGV) for KRT39 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294

Variation tolerance for KRT39 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRT39 Gene

Disorders for KRT39 Gene

Relevant External Links for KRT39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT39 Gene

Publications for KRT39 Gene

  1. Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalog. (PMID: 17301834) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2007) 3 4 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M. … Magin T.M. (Eur. J. Cell Biol. 2004) 3
  4. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRT39 Gene

Sources for KRT39 Gene