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Aliases for KRT38 Gene

Aliases for KRT38 Gene

  • Keratin 38 2 3
  • Keratin 38, Type I 2 3 5
  • Keratin, Hair, Acidic, 8 2 3
  • Hair Keratin, Type I Ha8 3 4
  • Keratin-38 3 4
  • KRTHA8 3 4
  • HHa8 3 4
  • K38 3 4
  • HKA8 4
  • HA8 3

External Ids for KRT38 Gene

Previous HGNC Symbols for KRT38 Gene

  • KRTHA8

Previous GeneCards Identifiers for KRT38 Gene

  • GC17M036847
  • GC17M039592
  • GC17M035356

Summaries for KRT38 Gene

Entrez Gene Summary for KRT38 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT38 Gene

KRT38 (Keratin 38) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT38 Gene

Genomics for KRT38 Gene

Regulatory Elements for KRT38 Gene

Enhancers for KRT38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT38 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT38 Gene

Chromosome:
17
Start:
41,436,369 bp from pter
End:
41,441,344 bp from pter
Size:
4,976 bases
Orientation:
Minus strand

Genomic View for KRT38 Gene

Genes around KRT38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT38 Gene

Proteins for KRT38 Gene

  • Protein details for KRT38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76015-KRT38_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha8
    Protein Accession:
    O76015
    Secondary Accessions:
    • A2RRM5
    • Q6A164

    Protein attributes for KRT38 Gene

    Size:
    456 amino acids
    Molecular mass:
    50480 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT38 Gene

Proteomics data for KRT38 Gene at MOPED

Post-translational modifications for KRT38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT38 Gene

Domains & Families for KRT38 Gene

Gene Families for KRT38 Gene

Protein Domains for KRT38 Gene

Suggested Antigen Peptide Sequences for KRT38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76015

UniProtKB/Swiss-Prot:

KRT38_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT38: view

Function for KRT38 Gene

Gene Ontology (GO) - Molecular Function for KRT38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT38: view

Phenotypes for KRT38 Gene

genes like me logo Genes that share phenotypes with KRT38: view

Animal Model Products

miRNA for KRT38 Gene

miRTarBase miRNAs that target KRT38

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT38 Gene

Localization for KRT38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT38 Gene COMPARTMENTS Subcellular localization image for KRT38 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT38 Gene

Pathways & Interactions for KRT38 Gene

SuperPathways for KRT38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRT38 Gene

Drugs & Compounds for KRT38 Gene

No Compound Related Data Available

Transcripts for KRT38 Gene

mRNA/cDNA for KRT38 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT38 Gene

Keratin 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT38 Gene

No ASD Table

Relevant External Links for KRT38 Gene

GeneLoc Exon Structure for
KRT38
ECgene alternative splicing isoforms for
KRT38

Expression for KRT38 Gene

mRNA expression in normal human tissues for KRT38 Gene

mRNA differential expression in normal tissues according to GTEx for KRT38 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.3).

Protein differential expression in normal tissues from HIPED for KRT38 Gene

This gene is overexpressed in Stomach (19.9), Breast (15.9), Esophagus (10.2), Hair follicle (9.5), and Skin (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT38 Gene



SOURCE GeneReport for Unigene cluster for KRT38 Gene Hs.248188

genes like me logo Genes that share expression patterns with KRT38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRT38 Gene

Orthologs for KRT38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT38 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KRT38 35
  • 83.6 (n)
  • 76.08 (a)
-- 36
  • 74 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRT38 35
  • 99.34 (n)
  • 98.9 (a)
KRT38 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX469912.1 36
  • 19 (a)
ManyToMany
cyt1 36
  • 37 (a)
ManyToMany
cyt1l 36
  • 37 (a)
ManyToMany
krt1-19d 36
  • 33 (a)
ManyToMany
krt15 36
  • 34 (a)
ManyToMany
krt17 36
  • 36 (a)
ManyToMany
si:dkeyp-113d7.4 36
  • 31 (a)
ManyToMany
wu:fb17f05 36
  • 39 (a)
ManyToMany
zgc:109868 36
  • 36 (a)
ManyToMany
zgc:136902 36
  • 34 (a)
ManyToMany
zgc:153629 36
  • 35 (a)
ManyToMany
zgc:92035 36
  • 34 (a)
ManyToMany
zgc:92061 36
  • 38 (a)
ManyToMany
zgc:92533 36
  • 19 (a)
ManyToMany
Species with no ortholog for KRT38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT38 Gene

ENSEMBL:
Gene Tree for KRT38 (if available)
TreeFam:
Gene Tree for KRT38 (if available)

Paralogs for KRT38 Gene

Pseudogenes.org Pseudogenes for KRT38 Gene

genes like me logo Genes that share paralogs with KRT38: view

Variants for KRT38 Gene

Sequence variations from dbSNP and Humsavar for KRT38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs897416 - 41,437,516(-) CCACG(C/T)CTCCC reference, missense
rs877459 -- 41,437,168(-) CTGGA(C/T)TGGAG utr-variant-3-prime
rs1350046 -- 41,440,359(-) TGTAA(A/G)GCTCA intron-variant
rs897415 -- 41,437,620(-) GGGAC(C/T)CCTTC intron-variant
rs1455529 -- 41,435,876(-) CCACC(C/T)GTGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRT38 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
esv2715932 CNV Deletion 23290073
dgv962e1 CNV Complex 17122850

Variation tolerance for KRT38 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRT38 Gene

Disorders for KRT38 Gene

Relevant External Links for KRT38

Genetic Association Database (GAD)
KRT38
Human Genome Epidemiology (HuGE) Navigator
KRT38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT38

No disorders were found for KRT38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT38 Gene

Publications for KRT38 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 2 3 4 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for KRT38 Gene

Sources for KRT38 Gene

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