KRT38 Gene
protein-coding GIFtS: 48
GCID: GC17M039592
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keratin 38(Previous names: keratin, hair, acidic, 8 )
(Previous symbol: KRTHA8)
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Aliases
for KRT38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 381 2 | | HHa81 | | KRTHA81 2 3 5 | | Keratin, Type I Cuticular Ha82 | | Keratin, Hair, Acidic, 81 2 | | Keratin-383 | | Hair Keratin, Type I Ha82 3 | | HHA83 | | K382 3 | | HKA83 | | HA82 5 | | Keratin-383 |
Export aliases for KRT38 gene to outside databasesPrevious GC identifers: GC17M036847 GC17M035356 |
Summaries
for KRT38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT38:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidicprotein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered ina region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
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Genomic Views
for KRT38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT38 gene promoter:
SRF Bach2 SRF (504 AA) CUTL1 AP-4 Nkx2-5 Evi-1 RORalpha2 c-Myb SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRT38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039592: view genomic region
(about GC identifiers)
Start:
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39,592,621 bp from pter |
End:
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39,597,596 bp from pter |
Size:
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4,976 bases |
Orientation:
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minus strand |
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Proteins
for KRT38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRT38_HUMAN, O76015 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha8 Size: 456 amino acids; 50480 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: A2RRM5 Q6A164Explore the universe of human proteins at neXtProt for KRT38: NX_O76015
KRT38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006762.3
ENSEMBL proteins: ENSP00000246646
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT38 for ontologies About GeneDecksing
KRT38 Antibody Products:
Assay Products for KRT38: |
Protein
Domains /
Families
for KRT38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT38 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76015ProtoNet protein and cluster: O76015 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: KRT38_HUMAN, O76015Similarity: Belongs to the intermediate filament family |
Function
for KRT38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT38 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT38 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT38 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT38
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for KRT38 (O760153 ENSP000002466464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for KRT38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT38
Search CenterWatch for drugs/clinical trials and news about KRT38
|
Transcripts
for KRT38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT38 gene: NM_006771.3 Unigene Cluster for KRT38: Keratin 38 Hs.248188 [show with all ESTs]Unigene Representative Sequence: NM_0067711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000246646(uc002hwq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT38 (NM_006771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT38 |
Additional cDNA sequence: AJ786656.1 BC131715.1 1 DOTS entry: DT.95301959 2 AceView cDNA sequences: NM_006771 AJ786656
GeneLoc Exon Structure
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Expression
for KRT38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGAGACC
About this image
See KRT38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT38
SOURCE GeneReport for Unigene cluster: Hs.248188
SABiosciences Custom PCR Arrays for KRT38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT38
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KRT38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT38 |
Orthologs
for KRT38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT38 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for KRT38 (if available)
TreeFam Gene Tree for KRT38 (if available) |
Paralogs
for KRT38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT38 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22
- KRT372 KRT322 KRT362 KRT33B2 KRT33A2
18/32 SIMAP similar genes for KRT38 using alignment to 1 protein entry: KRT38_HUMAN(see all similar genes):KRT37 KRTHA7 KRT33B KRT33A KRT34 KRT31
KRT15 KRT19 JUP KRT14 KRT16 KRT20
KRT35 keratin KRT13 KRT10 KRT17 KRT18
KRT38 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KRT38
PGOHUM00000237073
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Genomic Variants
for KRT38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT38 (39592621 - 39597596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT38
2 CNVs: 0205 4036
Human Gene Mutation Database (HGMD): KRT38
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KRT38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT38 for disorders About GeneDecksing
OMIM gene information: 604542
OMIM disorders: --
3  diseases for KRT38: About MalaCardsinflammatory bowel disease basal cell carcinoma carcinoma
Genetic Association Database (GAD): KRT38
Human Genome Epidemiology (HuGE) Navigator: KRT38 (1 document)
Export disorders for KRT38 gene to outside databases
|
Publications
for KRT38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT38 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2, 3 Rogers M.A.... Schweizer J. (1998)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. (PubMed id 15248378)1, 4 Buning C....Witt H. (2004)
- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1 Langbein L....Schweizer J. (1999)
- Human hair keratins. (PubMed id 7686952)1 Yu J....Bertolino A.P. (1993)
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External Searches for KRT38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT38 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT38 gene:
Search GeneIP for patents involving KRT38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT38 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT38 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT38 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT38 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT38 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT38 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT38 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT38 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT38 |
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| | | | Search Tocris compounds for KRT38 |
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 | | | KRT38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT38 |
|  |  |  | | | | ThermoFisher Antibodies for KRT38 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT38 |
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