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Aliases for KRT37 Gene

Aliases for KRT37 Gene

  • Keratin 37, Type I 2 3
  • KRTHA7 3 4 6
  • Keratin, Hair, Acidic, 7 2 3
  • Hair Keratin, Type I Ha7 3 4
  • Keratin-37 3 4
  • HA7 3 6
  • K37 3 4
  • Keratin, Type I Cuticular Ha7 3
  • Keratin 37 2
  • HHA7 4
  • HKA7 4

External Ids for KRT37 Gene

Previous HGNC Symbols for KRT37 Gene

  • KRTHA7

Previous GeneCards Identifiers for KRT37 Gene

  • GC17M036831
  • GC17M039581
  • GC17M035340

Summaries for KRT37 Gene

Entrez Gene Summary for KRT37 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT37 Gene

KRT37 (Keratin 37, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT37 Gene

Genomics for KRT37 Gene

Regulatory Elements for KRT37 Gene

Genomic Location for KRT37 Gene

Start:
41,420,557 bp from pter
End:
41,424,570 bp from pter
Size:
4,014 bases
Orientation:
Minus strand

Genomic View for KRT37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT37 Gene

Proteins for KRT37 Gene

  • Protein details for KRT37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76014-KRT37_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha7
    Protein Accession:
    O76014
    Secondary Accessions:

    Protein attributes for KRT37 Gene

    Size:
    449 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT37 Gene

Proteomics data for KRT37 Gene at MOPED

Post-translational modifications for KRT37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT37 Gene

Domains for KRT37 Gene

Gene Families for KRT37 Gene

HGNC:
  • IFF1 :Intermediate filaments type I, keratins (acidic)

Protein Domains for KRT37 Gene

Suggested Antigen Peptide Sequences for KRT37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76014

UniProtKB/Swiss-Prot:

KRT37_HUMAN :
  • O76014
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT37: view

Function for KRT37 Gene

Gene Ontology (GO) - Molecular Function for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT37: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT37

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT37 Gene

Localization for KRT37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT37 Gene COMPARTMENTS Subcellular localization image for KRT37 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
golgi apparatus 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT37 Gene

Pathways for KRT37 Gene

SuperPathways for KRT37 Gene

No Data Available

Interacting Proteins for KRT37 Gene

Selected Interacting proteins: O76014-KRT37_HUMAN for KRT37 Gene via I2D

Symbol External ID(s) Details
ELF3
YWHAG

Gene Ontology (GO) - Biological Process for KRT37 Gene

None

No data available for Pathways by source for KRT37 Gene

Transcripts for KRT37 Gene

mRNA/cDNA for KRT37 Gene

(11) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT37 Gene

Keratin 37:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT37

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT37
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT37 Gene

No ASD Table

Relevant External Links for KRT37 Gene

GeneLoc Exon Structure for
KRT37
ECgene alternative splicing isoforms for
KRT37

Expression for KRT37 Gene

mRNA expression in normal human tissues for KRT37 Gene

mRNA differential expression in normal tissues according to GTEx for KRT37 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT37 Gene

SOURCE GeneReport for Unigene cluster for KRT37 Gene Hs.673852

genes like me logo Genes that share expressions with KRT37: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRT37 Gene

Orthologs for KRT37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT37 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX469912.1 36
  • 19 (a)
ManyToMany
cyt1 36
  • 36 (a)
ManyToMany
cyt1l 36
  • 36 (a)
ManyToMany
krt1-19d 36
  • 33 (a)
ManyToMany
krt15 36
  • 33 (a)
ManyToMany
krt17 36
  • 36 (a)
ManyToMany
si:dkeyp-113d7.4 36
  • 30 (a)
ManyToMany
wu:fb17f05 36
  • 38 (a)
ManyToMany
zgc:109868 36
  • 35 (a)
ManyToMany
zgc:136902 36
  • 33 (a)
ManyToMany
zgc:153629 36
  • 35 (a)
ManyToMany
zgc:92035 36
  • 33 (a)
ManyToMany
zgc:92061 36
  • 37 (a)
ManyToMany
zgc:92533 36
  • 18 (a)
ManyToMany
Species with no ortholog for KRT37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT37 Gene

ENSEMBL:
Gene Tree for KRT37 (if available)
TreeFam:
Gene Tree for KRT37 (if available)

Paralogs for KRT37 Gene

Pseudogenes.org Pseudogenes for KRT37 Gene

genes like me logo Genes that share paralogs with KRT37: view

Variants for KRT37 Gene

Sequence variations from dbSNP and Humsavar for KRT37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1544368 -- 41,425,046(-) ATATC(A/G)GTAGA upstream-variant-2KB
rs2071603 -- 41,425,405(-) TAGTG(A/G)TTTCT upstream-variant-2KB
rs2071604 -- 41,422,689(-) CCTGG(C/G)CTCAG intron-variant
rs2071607 - 41,422,172(-) GCAGG(A/C)CATGT missense, reference
rs2857626 -- 41,421,632(-) GCTGA(C/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT37 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
esv2715932 CNV Deletion 23290073

Relevant External Links for KRT37 Gene

HapMap Linkage Disequilibrium report
KRT37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT37 Gene

Disorders for KRT37 Gene

No disorders were found for KRT37 Gene.

No data available for UniProtKB/Swiss-Prot for KRT37 Gene

Publications for KRT37 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 2 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L. … Schweizer J. (J. Biol. Chem. 1999) 3

Products for KRT37 Gene

Sources for KRT37 Gene

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