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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT37 Gene

protein-coding   GIFtS: 44
GCID: GC17M039581

Keratin 37

(Previous names: keratin, hair, acidic, 7)
(Previous symbol: KRTHA7)
  Search for KRT37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 371 2     Keratin, Type I Cuticular Ha72
KRTHA71 2 3 5     keratin-372
Keratin, Hair, Acidic, 71 2     HHA73
Hair Keratin, Type I Ha72 3     HKA73
K372 3     Keratin-373
HA72 5     

External Ids:    HGNC: 64551   Entrez Gene: 86882   Ensembl: ENSG000001084177   OMIM: 6045415   UniProtKB: O760143   

Export aliases for KRT37 gene to outside databases

Previous GC identifers: GC17M036831 GC17M035340


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT37 Gene:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic
protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are
clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq,
Jul 2008)

GeneCards Summary for KRT37 Gene: 
KRT37 (keratin 37) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT37 gene promoter:
         FOXF2   FOXO4   Bach2   c-Myb   AP-4   Pax-4a   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT37 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT37 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039581:  view genomic region     (about GC identifiers)

Start:
39,576,809 bp from pter      End:
39,580,822 bp from pter
Size:
4,014 bases      Orientation:
minus strand

1 alternative location:
Chr17+,NW_003315953 8,366-12,379     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KRT37_HUMAN, O76014 (See protein sequence)
Recommended Name: Keratin, type I cuticular Ha7  
Size: 449 amino acids; 49747 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

Explore the universe of human proteins at neXtProt for KRT37: NX_O76014

Explore proteomics data for KRT37 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76014

  • KRT37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT37 Protein Expression
    REFSEQ proteins: NP_003761.3  
    ENSEMBL proteins: 
     ENSP00000225550  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    KRT37 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry O76014

    ProtoNet protein and cluster: O76014

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: KRT37_HUMAN, O76014
    Similarity: Belongs to the intermediate filament family


    KRT37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT37 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT37

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KRT37 (O760143 ENSP000002255504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    ELF3P785453, ENSP000003526734I2D: score=1 STRING: ENSP00000352673
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT37

    Search CenterWatch for drugs/clinical trials and news about KRT37

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for KRT37 gene: 
    NM_003770.4  

    Unigene Cluster for KRT37:

    Keratin 37
    Hs.673852  [show with all ESTs]
    Unigene Representative Sequence: NM_003770
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225550(uc002hwp.1)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT37

    Additional mRNA sequence: AJ786655.1 

    3 DOTS entries:

    DT.92030585  DT.91668057  DT.91875473 

    11 AceView cDNA sequences:

    NM_003770 AJ786655 BF756993 BF336916 BQ320456 BF759685 BF760155 BQ320632 
    BF757134 BF083546 BF758777 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCAATTA
    KRT37 Expression
    About this image


    See KRT37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT37

    SOURCE GeneReport for Unigene cluster: Hs.673852
        SABiosciences Custom PCR Arrays for KRT37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for KRT37 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    Uncharacterized protein
    73(a)
    71(a)
    many ↔ many
    many ↔ many
    9(21321398-21325239)
    9(21351688-21357813)


    ENSEMBL Gene Tree for KRT37 (if available)
    TreeFam Gene Tree for KRT37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT37 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT272  
    KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT132  KRT262  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/37 SIMAP similar genes for KRT37 using alignment to 1 protein entry:     KRT37_HUMAN(see all similar genes):
    KRTHA7    KRT38    KRT33B    KRT34    KRT31    KRT33A
    JUP    K14    KRT32    KRT15    KRT19    KRT20
    KRT35    KRT13    KRT14    KRT16    keratin    KRT17

    KRT37 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT37
    PGOHUM00000237075


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 SNPs in KRT37 are shown (see all 278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175059291,2
    C,F--35340391(-) AATGCA/GGGGAA 1 -- ut311Minor allele frequency- G:0.03EA 120
    rs754455451,2
    C--39576471(+) TTGACG/AATATT 2 -- ds50014Minor allele frequency- A:0.21NA WA EA 360
    rs1405426471,2
    C,F--39577151(+) GCTCCA/GTGGCC 4 H syn12Minor allele frequency- G:0.00NA EU 5857
    rs1474770381,2
    C,F--39577172(+) CCACCG/AGTGAC 4 /T syn11Minor allele frequency- A:0.00NA 4552
    rs177370191,2,4
    C,F,H--39577180(+) GACAGG/AGCCAC 4 /P /S mis122Minor allele frequency- A:0.04NA NS EA EU 7953
    rs1445735701,2
    C,F--39577186(+) GCCACA/CGCTTG 4 G C mis11Minor allele frequency- C:0.00NA 4552
    rs1385293501,2
    C,F--39577188(+) CACAGC/ATTGGA 4 /S /I mis12Minor allele frequency- A:0.00NA EU 5873
    rs80718141,2,4
    C,F,H--39577215(+) CAGGCG/ATGGAA 4 /T /M mis1 ese323Minor allele frequency- A:0.07NA NS EA WA EU 8423
    rs353719721,2,4
    C,F--39577218(+) GCGTGG/AAACAG 4 /S /F mis16Minor allele frequency- A:0.03NA CSA WA 4756
    rs1399438251,2
    C--39577266(+) TACATA/TAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for KRT37 (39576809 - 39580822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KRT37:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715932CNV Deletion23290073
    nsv483014CNV Loss15286789
    dgv961e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): KRT37
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KRT37 for disorders           About MalaCards
    OMIM gene information: 604541    OMIM disorders: --


    KRT37 for disorders           About GeneDecksing


    Export disorders for KRT37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT37 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KRT37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2, 3 Rogers M.A.... Schweizer J. (1998)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    3. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
    4. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1 Rogers M.A.... Schweizer J. (2004)
    5. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1 Langbein L....Schweizer J. (1999)
    6. Human hair keratins. (PubMed id 7686952)1 Yu J....Bertolino A.P. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8688 HGNC: 6455 AceView: KRTHA7 Ensembl:ENSG00000108417 euGenes: HUgn8688
    ECgene: KRT37 H-InvDB: KRT37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT37 gene:
    Search GeneIP for patents involving KRT37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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