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Aliases for KRT37 Gene

Aliases for KRT37 Gene

  • Keratin 37 2 3 5
  • Keratin, Hair, Acidic, 7 2 3
  • Hair Keratin, Type I Ha7 3 4
  • Keratin 37, Type I 2 3
  • KRTHA7 3 4
  • K37 3 4
  • Keratin, Type I Cuticular Ha7 3
  • Keratin-37 4
  • HHA7 4
  • HKA7 4
  • HA7 3

External Ids for KRT37 Gene

Previous HGNC Symbols for KRT37 Gene

  • KRTHA7

Previous GeneCards Identifiers for KRT37 Gene

  • GC17M036831
  • GC17M039581
  • GC17M035340

Summaries for KRT37 Gene

Entrez Gene Summary for KRT37 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT37 Gene

KRT37 (Keratin 37) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT38.

Additional gene information for KRT37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT37 Gene

Genomics for KRT37 Gene

Regulatory Elements for KRT37 Gene

Enhancers for KRT37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H041649 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -230.1 -230076 9 HDGF ARNT ZNF133 YBX1 BRCA1 TCF12 GLIS2 ZNF207 ATF7 RUNX3 ENSG00000267758 JUP HSD17B1 DHX58 GHDC ENSG00000259623 KRT14 CNP PSMC3IP RETREG3
GH17H040908 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +511.6 511595 8 FOXA2 ATF1 MLX ARID4B ZNF143 FOS ATF7 RUNX3 DEK SP5 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17H040900 1.6 Ensembl ENCODE dbSUPER 9.7 +521.8 521772 5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS KRT23 SNORD124 KRT12 TMEM99 KRT28 KRTAP3-2 KRT40 KRT37 KRT38 KRT26
GH17H041620 1.3 FANTOM5 ENCODE 9.4 -199.6 -199628 6 TBP PKNOX1 NFIB KLF17 BRCA1 GLIS2 ZNF366 RCOR1 KLF7 EGR2 KRT9 KRT15 KRT14 KRT19 KRT40 ENSG00000234477 KRT37 KRT16 KRT36 JUP
GH17H040848 1.2 Ensembl ENCODE 9.6 +572.5 572517 6 PKNOX1 FOXA2 ATF1 ZNF133 FEZF1 TCF12 ATF7 FOS YY2 NCOA1 TMEM99 SMARCE1 KRT20 KRT28 ENSG00000234477 KRT37 LOC100505782 KRT31 MED24 ENSG00000265359
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT37 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT37 Gene

41,420,557 bp from pter
41,424,570 bp from pter
4,014 bases
Minus strand

Genomic View for KRT37 Gene

Genes around KRT37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT37 Gene

Proteins for KRT37 Gene

  • Protein details for KRT37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha7
    Protein Accession:

    Protein attributes for KRT37 Gene

    449 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT37 Gene

Post-translational modifications for KRT37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT37 Gene

Domains & Families for KRT37 Gene

Gene Families for KRT37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT37: view

Function for KRT37 Gene

Phenotypes From GWAS Catalog for KRT37 Gene

Gene Ontology (GO) - Molecular Function for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT37: view

Phenotypes for KRT37 Gene

genes like me logo Genes that share phenotypes with KRT37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KRT37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT37 Gene

Localization for KRT37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT37 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT37 Gene

Pathways & Interactions for KRT37 Gene

SuperPathways for KRT37 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT37: view

Pathways by source for KRT37 Gene

2 Reactome pathways for KRT37 Gene

Interacting Proteins for KRT37 Gene

Gene Ontology (GO) - Biological Process for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT37: view

No data available for SIGNOR curated interactions for KRT37 Gene

Drugs & Compounds for KRT37 Gene

No Compound Related Data Available

Transcripts for KRT37 Gene

mRNA/cDNA for KRT37 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT37 Gene

Keratin 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KRT37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KRT37 Gene

No ASD Table

Relevant External Links for KRT37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT37 Gene

mRNA differential expression in normal tissues according to GTEx for KRT37 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.7).

Protein differential expression in normal tissues from HIPED for KRT37 Gene

This gene is overexpressed in Skin (54.0) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT37 Gene

Protein tissue co-expression partners for KRT37 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT37 Gene:


SOURCE GeneReport for Unigene cluster for KRT37 Gene:


Evidence on tissue expression from TISSUES for KRT37 Gene

  • Blood(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT37 Gene

Orthologs for KRT37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT37 34
  • 98 (a)
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
-- 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
-- 34
  • 39 (a)
(Danio rerio)
Actinopterygii wu:fb17f05 34
  • 38 (a)
zgc:92061 34
  • 37 (a)
cyt1 34
  • 36 (a)
cyt1l 34
  • 36 (a)
krt17 34
  • 36 (a)
zgc:109868 34
  • 35 (a)
zgc:153629 34
  • 35 (a)
krt1-19d 34
  • 33 (a)
krt15 34
  • 33 (a)
zgc:136902 34
  • 33 (a)
zgc:92035 34
  • 33 (a)
si:dkeyp-113d7.4 34
  • 30 (a)
BX469912.1 34
  • 19 (a)
zgc:92533 34
  • 18 (a)
Species where no ortholog for KRT37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT37 Gene

Gene Tree for KRT37 (if available)
Gene Tree for KRT37 (if available)

Paralogs for KRT37 Gene

Paralogs for KRT37 Gene Pseudogenes for KRT37 Gene

genes like me logo Genes that share paralogs with KRT37: view

Variants for KRT37 Gene

Sequence variations from dbSNP and Humsavar for KRT37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000243811 -- 41,423,586(+) TATTC(G/T)CTTTC intron-variant
rs1001060879 -- 41,422,593(+) ACCTG(C/G)ACACC intron-variant
rs1001318303 -- 41,424,602(+) TCCTC(-/CCAA)CCCTT upstream-variant-2KB
rs1002839701 -- 41,424,854(+) TCAGG(C/T)CCCAA upstream-variant-2KB
rs1003201509 -- 41,426,113(+) GGAGG(C/T)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT37 Gene

Variant ID Type Subtype PubMed ID
esv2715932 CNV deletion 23290073
esv2758690 CNV gain+loss 17122850
nsv1071383 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789

Variation tolerance for KRT37 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.12; 99.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT37 Gene

Disorders for KRT37 Gene

Relevant External Links for KRT37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT37 Gene

Publications for KRT37 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 60
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 60
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 60
  4. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M … Superti-Furga G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 60
  5. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 60

Products for KRT37 Gene

Sources for KRT37 Gene

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