KRT37 Gene
protein-coding GIFtS: 45
GCID: GC17M039581
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keratin 37(Previous names: keratin, hair, acidic, 7 )
(Previous symbol: KRTHA7)
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Aliases
for KRT37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 371 2 | | Keratin, Type I Cuticular Ha72 | | KRTHA71 2 3 5 | | Keratin-373 | | Keratin, Hair, Acidic, 71 2 | | HHA73 | | Hair Keratin, Type I Ha72 3 | | HKA73 | | K372 3 | | Keratin-373 | | HA72 5 | | |
Export aliases for KRT37 gene to outside databasesPrevious GC identifers: GC17M036831 GC17M035340 |
Summaries
for KRT37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT37:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidicprotein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered ina region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
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Genomic Views
for KRT37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT37 gene promoter:
FOXF2 FOXO4 Bach2 c-Myb AP-4 Pax-4a Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRT37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039581: view genomic region
(about GC identifiers)
Start:
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39,576,809 bp from pter |
End:
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39,581,110 bp from pter |
Size:
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4,302 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17+,PATCHES 39,468,065-39,472,078 |
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Proteins
for KRT37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRT37_HUMAN, O76014 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha7 Size: 449 amino acids; 49747 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)Explore the universe of human proteins at neXtProt for KRT37: NX_O76014
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76014
KRT37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003761.3
ENSEMBL proteins: ENSP00000225550
Human Recombinant Protein Products for KRT37:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT37 for ontologies About GeneDecksing
KRT37 Antibody Products:
Assay Products for KRT37: |
Protein
Domains /
Families
for KRT37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT37 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76014ProtoNet protein and cluster: O76014 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: KRT37_HUMAN, O76014Similarity: Belongs to the intermediate filament family |
Function
for KRT37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT37 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KRT37 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT37 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT37 |
|
Pathways & Interactions
for KRT37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT37
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KRT37 (O760143 ENSP000002255504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRT37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT37
Search CenterWatch for drugs/clinical trials and news about KRT37
|
Transcripts
for KRT37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT37 gene: NM_003770.4 Unigene Cluster for KRT37: Keratin 37 Hs.673852 [show with all ESTs]Unigene Representative Sequence: NM_0037701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000225550(uc002hwp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT37 (NM_003770) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT37 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT37 |
Additional cDNA sequence: AJ786655.1 3 DOTS entries: DT.92030585 DT.91668057 DT.91875473 11 AceView cDNA sequences: NM_003770 AJ786655 BF756993 BF336916 BQ320456 BF760155 BF759685 BF757134 BQ320632 BF083546 BF758777
GeneLoc Exon Structure
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Expression
for KRT37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCAATTA
About this image
See KRT37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT37
SOURCE GeneReport for Unigene cluster: Hs.673852
SABiosciences Custom PCR Arrays for KRT37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KRT37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT37 |
Orthologs
for KRT37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT37 gene from 2/5 species (see all 5) About this table
ENSEMBL Gene Tree for KRT37 (if available)
TreeFam Gene Tree for KRT37 (if available) |
Paralogs
for KRT37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT37 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22
- KRT322 KRT382 KRT362 KRT33B2 KRT33A2
18/37 SIMAP similar genes for KRT37 using alignment to 1 protein entry: KRT37_HUMAN(see all similar genes):KRTHA7 KRT38 KRT33B KRT34 KRT31 KRT33A
JUP K14 KRT32 KRT15 KRT19 KRT20
KRT35 KRT13 KRT14 KRT16 keratin KRT17
KRT37 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KRT37
PGOHUM00000237075
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Genomic Variants
for KRT37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT37 (39576809 - 39581110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT37
2 CNVs: 0205 4036
Human Gene Mutation Database (HGMD): KRT37
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT37 |
|
Disorders
/ Diseases
for KRT37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KRT37 for disorders About MalaCards
KRT37 for disorders About GeneDecksing
OMIM gene information: 604541
OMIM disorders: --
Export disorders for KRT37 gene to outside databases
|
Publications
for KRT37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2, 3 Rogers M.A.... Schweizer J. (1998)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1 Rogers M.A.... Schweizer J. (2004)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1 Langbein L....Schweizer J. (1999)
- Human hair keratins. (PubMed id 7686952)1 Yu J....Bertolino A.P. (1993)
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External Searches for KRT37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT37 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT37 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT37 gene:
Search GeneIP for patents involving KRT37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT37 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT37 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT37 | | | OriGene Protein Over-expression Lysate for KRT37 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT37 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT37 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KRT37 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT37 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT37 |
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