KRT36 Gene
protein-coding GIFtS: 47
GCID: GC17M039642
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|
keratin 36(Previous names: keratin, hair, acidic, 6 )
(Previous symbol: KRTHA6)
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Aliases
for KRT36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 361 2 | | HHa61 | | KRTHA61 2 3 5 | | Keratin, Type I Cuticular Ha62 | | Keratin, Hair, Acidic, 61 2 | | Keratin-363 | | Hair Keratin, Type I Ha62 3 | | HHA63 | | K362 3 | | HKA63 | | HA62 5 | | Keratin-363 |
Export aliases for KRT36 gene to outside databasesPrevious GC identifers: GC17M036896 GC17M035406 |
Summaries
for KRT36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT36:
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic proteinwhich heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a regionof chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
Gene Wiki entry for KRT36
|
Genomic Views
for KRT36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT36 gene promoter:
p53 Pax-6 ARP-1 HNF-4alpha2 Nkx2-5 HNF-4alpha1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT36
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT36 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRT36 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039642: view genomic region
(about GC identifiers)
Start:
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39,642,388 bp from pter |
End:
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39,648,798 bp from pter |
Size:
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6,411 bases |
Orientation:
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minus strand |
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Proteins
for KRT36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRT36_HUMAN, O76013 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha6 Size: 467 amino acids; 52247 Da
Subunit: Heterotetramer of two type I and two type II keratins (By similarity)
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: Q86XG4Alternative splicing: 2 isoforms: O76013-1 O76013-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KRT36: NX_O76013
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76013
KRT36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003762.1
ENSEMBL proteins: ENSP00000329165 ENSP00000377555
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005882 | intermediate filament |
IEA | -- | | GO:0045111 | intermediate filament cytoskeleton |
-- | -- |
KRT36 for ontologies About GeneDecksing
KRT36 Antibody Products:
Assay Products for KRT36: |
Protein
Domains /
Families
for KRT36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT36 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76013ProtoNet protein and cluster: O76013 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: KRT36_HUMAN, O76013Similarity: Belongs to the intermediate filament family |
Function
for KRT36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KRT36 (NM_003771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT36 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT36 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT36 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030280 | structural constituent of epidermis |
NAS | 9756910 |
KRT36 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT36
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/15 Interacting proteins for KRT36 (O760132, 3 ENSP000003291654) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0045616 | regulation of keratinocyte differentiation |
IEA | -- |
KRT36 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT36
Search CenterWatch for drugs/clinical trials and news about KRT36
|
Transcripts
for KRT36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT36 gene: NM_003771.4 Unigene Cluster for KRT36: Keratin 36 Hs.248189 [show with all ESTs]Unigene Representative Sequence: BC0435812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328119(uc002hwt.3) ENST00000393986
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT36 (NM_003771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT36 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT36 |
Additional cDNA sequence: BC043581.1 3 DOTS entries: DT.92030344 DT.95203465 DT.97822767 7 AceView cDNA sequences: BC043581 NM_003771 CA306205 BI833804 BG980230 BQ318441 BQ318418
GeneLoc Exon Structure
|
Expression
for KRT36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAACCAGG
About this image
See KRT36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT36
SOURCE GeneReport for Unigene cluster: Hs.248189
UniProtKB/Swiss-Prot: KRT36_HUMAN, O76013Tissue specificity: Expressed in the hair follicles
SABiosciences Custom PCR Arrays for KRT36
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT36
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KRT36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT36 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT36 |
Orthologs
for KRT36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT36 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for KRT36 (if available)
TreeFam Gene Tree for KRT36 (if available) |
Paralogs
for KRT36 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT36 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22
- KRT372 KRT322 KRT382 KRT33B2 KRT33A2
18/35 SIMAP similar genes for KRT36 using alignment to 1 protein entry: KRT36_HUMAN(see all similar genes):KRT31 KRT34 KRT35 KRT33B KRT15 KRT19
keratin KRT33A KRT32 KRT40 KRTHA7 KRT13
KRT16 KRT18 KRT39 KRT9 KRT10 KRT37
KRT36 for paralogs About GeneDecksing
|
Genomic Variants
for KRT36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT36 (39642388 - 39648798 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KRT36
3 CNVs: 0205 30831 4036 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KRT36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT36 for disorders About GeneDecksing
OMIM gene information: 604540
OMIM disorders: --
1  disease for KRT36: About MalaCardsinfluenza
Export disorders for KRT36 gene to outside databases
|
Publications
for KRT36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT36 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KRT36) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2, 3 Rogers M.A.... Schweizer J. (1998)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KRT36 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT36 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT36 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT36 gene:
Search GeneIP for patents involving KRT36
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT36 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT36 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT36 | | | OriGene Protein Over-expression Lysate for KRT36 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT36 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT36 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KRT36 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT36 |
|  |  |  | | | | Search ThermoFisher Antibodies for KRT36 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT36 |
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