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Aliases for KRT36 Gene

Aliases for KRT36 Gene

  • Keratin 36 2 3 5
  • Keratin, Hair, Acidic, 6 2 3
  • Hair Keratin, Type I Ha6 3 4
  • Keratin 36, Type I 2 3
  • KRTHA6 3 4
  • HHa6 3 4
  • K36 3 4
  • Keratin, Type I Cuticular Ha6 3
  • Keratin-36 4
  • HKA6 4
  • HA6 3

External Ids for KRT36 Gene

Previous HGNC Symbols for KRT36 Gene

  • KRTHA6

Previous GeneCards Identifiers for KRT36 Gene

  • GC17M036896
  • GC17M039642
  • GC17M035406

Summaries for KRT36 Gene

Entrez Gene Summary for KRT36 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT36 Gene

KRT36 (Keratin 36) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT35.

Gene Wiki entry for KRT36 Gene

Additional gene information for KRT36 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT36 Gene

Genomics for KRT36 Gene

Regulatory Elements for KRT36 Gene

Enhancers for KRT36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H041518 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -31.2 -31240 13 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B ZNF766 FOS SMARCE1 ENSG00000267758 KRT19 ACLY DHX58 KRT36 ENSG00000259623 KRT14 STAT5A STAT5B
GH17H041534 1.4 FANTOM5 ENCODE dbSUPER 10.6 -43.2 -43228 5 PKNOX1 FOXA2 NFIB SIN3A NFXL1 BMI1 ZBTB7B ZNF121 RCOR1 HCFC1 ENSG00000267758 SMARCE1 KRT36 STAT5A KRT35 GHDC NAGLU KRT31 LOC100505782 KRT19
GH17H041578 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -90.2 -90179 10 TBP PKNOX1 NFIB RAD21 ZNF143 ATF7 CREM EGR2 ZNF654 SP3 KRT16 JUP KRT36 KRT9 KRT14 KRT15 KRT17 KRT13 KRT19
GH17H041532 0.9 ENCODE dbSUPER 11.1 -39.1 -39120 1 BCOR SMARCA5 HLF CEBPB ZMYM3 CEBPG SREBF1 ZNF664 ZNF316 CEBPA KRT36 KRT14 LOC100505782 KRT31 ENSG00000234477 KRT19 LINC00974
GH17H041401 1.3 Ensembl ENCODE 6.8 +90.3 90344 3 PKNOX1 FOXA2 FEZF1 GLIS2 FOS JUNB TSHZ1 ZNF518A NFIL3 STAT3 KRT34 KRT38 SMARCE1 ENSG00000267758 KRT36 LOC100505782 KRT41P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT36 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT36 Gene

41,486,136 bp from pter
41,494,015 bp from pter
7,880 bases
Minus strand

Genomic View for KRT36 Gene

Genes around KRT36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT36 Gene

Proteins for KRT36 Gene

  • Protein details for KRT36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha6
    Protein Accession:
    Secondary Accessions:
    • Q86XG4

    Protein attributes for KRT36 Gene

    467 amino acids
    Molecular mass:
    52247 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Alternative splice isoforms for KRT36 Gene


neXtProt entry for KRT36 Gene

Post-translational modifications for KRT36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT36 Gene

Domains & Families for KRT36 Gene

Gene Families for KRT36 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT36: view

Function for KRT36 Gene

Gene Ontology (GO) - Molecular Function for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030280 structural constituent of epidermis NAS 9756910
genes like me logo Genes that share ontologies with KRT36: view
genes like me logo Genes that share phenotypes with KRT36: view

Animal Models for KRT36 Gene

MGI Knock Outs for KRT36:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KRT36
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KRT36 Gene

Localization for KRT36 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT36 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045111 intermediate filament cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT36 Gene

Pathways & Interactions for KRT36 Gene

SuperPathways for KRT36 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT36: view

Pathways by source for KRT36 Gene

2 Reactome pathways for KRT36 Gene

Gene Ontology (GO) - Biological Process for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0045616 regulation of keratinocyte differentiation IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT36: view

No data available for SIGNOR curated interactions for KRT36 Gene

Drugs & Compounds for KRT36 Gene

No Compound Related Data Available

Transcripts for KRT36 Gene

mRNA/cDNA for KRT36 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT36 Gene

Keratin 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KRT36
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KRT36 Gene

No ASD Table

Relevant External Links for KRT36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT36 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x21.5), Skin - Sun Exposed (Lower leg) (x6.3), and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for KRT36 Gene

This gene is overexpressed in Skin (14.2), Bone marrow mesenchymal stem cell (12.4), Plasma (8.4), and Saliva (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT36 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT36 Gene:


SOURCE GeneReport for Unigene cluster for KRT36 Gene:


mRNA Expression by UniProt/SwissProt for KRT36 Gene:

Tissue specificity: Expressed in the hair follicles.

Evidence on tissue expression from TISSUES for KRT36 Gene

  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT36: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT36 Gene

Orthologs for KRT36 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT36 33 34
  • 98.72 (n)
(Canis familiaris)
Mammalia KRT36 33 34
  • 88.7 (n)
(Bos Taurus)
Mammalia KRT36 33 34
  • 87.67 (n)
(Mus musculus)
Mammalia Krt36 33 16 34
  • 85.8 (n)
(Rattus norvegicus)
Mammalia Krt36 33
  • 85.07 (n)
(Monodelphis domestica)
Mammalia KRT36 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
-- 34
  • 70 (a)
Species where no ortholog for KRT36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT36 Gene

Gene Tree for KRT36 (if available)
Gene Tree for KRT36 (if available)

Paralogs for KRT36 Gene

Paralogs for KRT36 Gene

genes like me logo Genes that share paralogs with KRT36: view

Variants for KRT36 Gene

Sequence variations from dbSNP and Humsavar for KRT36 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001507585 -- 41,490,805(+) CACTG(A/G)GTCCT upstream-variant-2KB
rs1001556857 -- 41,491,080(+) GCTTG(A/G/T)ATCAC upstream-variant-2KB
rs1002005613 -- 41,486,659(+) GCGAG(A/C)CCGGT intron-variant
rs1002253929 -- 41,489,482(+) CGTAC(C/G)ACTCC reference, missense
rs1003127961 -- 41,491,751(+) TTTGT(C/T)GTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT36 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv3640588 CNV gain 21293372
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489
nsv524606 CNV loss 19592680
nsv526466 CNV gain 19592680
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495

Variation tolerance for KRT36 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.74; 98.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT36 Gene

Disorders for KRT36 Gene

Relevant External Links for KRT36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT36 Gene

Publications for KRT36 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 60
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 60
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N … Gallagher E (The EMBO journal 2014) 3 60
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 60
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60

Products for KRT36 Gene

Sources for KRT36 Gene

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