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Aliases for KRT36 Gene

Aliases for KRT36 Gene

  • Keratin 36, Type I 2 3
  • KRTHA6 3 4 6
  • Keratin, Hair, Acidic, 6 2 3
  • Hair Keratin, Type I Ha6 3 4
  • Keratin-36 3 4
  • HHa6 3 4
  • HA6 3 6
  • K36 3 4
  • Keratin, Type I Cuticular Ha6 3
  • Keratin 36 2
  • HKA6 4

External Ids for KRT36 Gene

Previous HGNC Symbols for KRT36 Gene

  • KRTHA6

Previous GeneCards Identifiers for KRT36 Gene

  • GC17M036896
  • GC17M039642
  • GC17M035406

Summaries for KRT36 Gene

Entrez Gene Summary for KRT36 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT36 Gene

KRT36 (Keratin 36, Type I) is a Protein Coding gene. GO annotations related to this gene include structural constituent of epidermis. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT36 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT36 Gene

Genomics for KRT36 Gene

Regulatory Elements for KRT36 Gene

Genomic Location for KRT36 Gene

41,486,136 bp from pter
41,492,546 bp from pter
6,411 bases
Minus strand

Genomic View for KRT36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT36 Gene

Proteins for KRT36 Gene

  • Protein details for KRT36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha6
    Protein Accession:
    Secondary Accessions:
    • Q86XG4

    Protein attributes for KRT36 Gene

    467 amino acids
    Molecular mass:
    52247 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

    Alternative splice isoforms for KRT36 Gene


neXtProt entry for KRT36 Gene

Proteomics data for KRT36 Gene at MOPED

Post-translational modifications for KRT36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT36 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT36 Gene

Domains for KRT36 Gene

Gene Families for KRT36 Gene

Suggested Antigen Peptide Sequences for KRT36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT36: view

Function for KRT36 Gene

Gene Ontology (GO) - Molecular Function for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0030280 structural constituent of epidermis NAS 9756910
genes like me logo Genes that share ontologies with KRT36: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT36

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT36 Gene

Localization for KRT36 Gene

Subcellular locations from

Jensen Localization Image for KRT36 Gene COMPARTMENTS Subcellular localization image for KRT36 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0045111 intermediate filament cytoskeleton --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT36 Gene

Pathways for KRT36 Gene

SuperPathways for KRT36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045616 regulation of keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with KRT36: view

No data available for Pathways by source for KRT36 Gene

Transcripts for KRT36 Gene

mRNA/cDNA for KRT36 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT36 Gene

Keratin 36:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT36 Gene

No ASD Table

Relevant External Links for KRT36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT36 Gene

mRNA expression in normal human tissues for KRT36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT36 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (21.5), Skin - Sun Exposed (Lower leg) (6.3), and Spleen (4.0).

Protein differential expression in normal tissues for KRT36 Gene

This gene is overexpressed in Skin (14.2), Bone marrow mesenchymal stem cell (12.4), Plasma (8.4), and Saliva (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT36 Gene

SOURCE GeneReport for Unigene cluster for KRT36 Gene Hs.248189

mRNA Expression by UniProt/SwissProt for KRT36 Gene

Tissue specificity: Expressed in the hair follicles.
genes like me logo Genes that share expressions with KRT36: view

Primer Products

In Situ Assay Products

No data available for Expression partners for KRT36 Gene

Orthologs for KRT36 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT36 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT36 35
  • 87.67 (n)
  • 86.12 (a)
KRT36 36
  • 86 (a)
(Canis familiaris)
Mammalia KRT36 35
  • 88.7 (n)
  • 89.42 (a)
KRT36 36
  • 89 (a)
(Mus musculus)
Mammalia Krt36 35
  • 85.8 (n)
  • 84.37 (a)
Krt36 16
Krt36 36
  • 84 (a)
(Pan troglodytes)
Mammalia KRT36 35
  • 98.72 (n)
  • 97.86 (a)
KRT36 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Krt36 35
  • 85.07 (n)
  • 85.87 (a)
(Monodelphis domestica)
Mammalia KRT36 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
-- 36
  • 78 (a)
Species with no ortholog for KRT36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT36 Gene

Gene Tree for KRT36 (if available)
Gene Tree for KRT36 (if available)

Paralogs for KRT36 Gene

genes like me logo Genes that share paralogs with KRT36: view

Variants for KRT36 Gene

Sequence variations from dbSNP and Humsavar for KRT36 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs721411 -- 41,492,692(-) ATATG(A/G)GTACT upstream-variant-2KB
rs897418 -- 41,485,680(-) ATCCT(C/G)AGCCA downstream-variant-500B
rs1003840 -- 41,490,081(-) GATTT(C/G)ATTTT upstream-variant-2KB, intron-variant
rs1003841 -- 41,490,047(-) GGTTC(C/T)GGATG upstream-variant-2KB, intron-variant
rs1003842 -- 41,489,769(-) ATCCG(C/T)TCTGT synonymous-codon, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT36 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
dgv962e1 CNV Complex 17122850
nsv510711 CNV Loss 20534489
nsv526466 CNV Gain 19592680
nsv524606 CNV Loss 19592680
nsv9555 CNV Gain 18304495
nsv827992 CNV Gain 20364138

Relevant External Links for KRT36 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT36 Gene

Disorders for KRT36 Gene

No disorders were found for KRT36 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRT36 Gene

Publications for KRT36 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 2 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for KRT36 Gene

Sources for KRT36 Gene

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