KRT35 Gene
protein-coding GIFtS: 47
GCID: GC17M039632
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|
keratin 35(Previous names: keratin, hair, acidic, 5 )
(Previous symbol: KRTHA5)
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Aliases
for KRT35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 351 2 | | Hard Keratin, Type I, 52 | | KRTHA51 2 3 5 | | HHa5 Hair Keratin Type I Intermediate Filament2 | | Ha-51 2 | | Keratin, Type I Cuticular Ha52 | | Keratin, Hair, Acidic, 51 2 | | Keratin-353 | | Hair Keratin, Type I Ha52 3 | | HHA53 | | K352 3 | | HKA53 | | HA52 | | Keratin-353 | | HHa51 | | |
Export aliases for KRT35 gene to outside databasesPrevious GC identifers: GC17M036887 GC17M035396 |
Summaries
for KRT35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT35:
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic proteinwhich heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a regionof chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
|
Genomic Views
for KRT35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT35 gene promoter:
CHOP-10 p53 Pax-6 ARP-1 Nkx2-5 E47 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KRT35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039632: view genomic region
(about GC identifiers)
Start:
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39,632,941 bp from pter |
End:
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39,637,392 bp from pter |
Size:
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4,452 bases |
Orientation:
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minus strand |
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Proteins
for KRT35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha5 Size: 455 amino acids; 50361 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Sequence caution: Sequence=CAA62286.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAA76387.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O76012 Q92651Explore the universe of human proteins at neXtProt for KRT35: NX_Q92764
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92764
KRT35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002271.3
ENSEMBL proteins: ENSP00000246639 ENSP00000377558
Human Recombinant Protein Products for KRT35:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT35 for ontologies About GeneDecksing
KRT35 Antibody Products:
Assay Products for KRT35: |
Protein
Domains /
Families
for KRT35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT35 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92764ProtoNet protein and cluster: Q92764 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764Similarity: Belongs to the intermediate filament family |
Function
for KRT35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT35 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KRT35 (NM_002280) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT35 |
|
Pathways & Interactions
for KRT35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT35
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for KRT35 (Q927643 ENSP000003775584) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009653 | anatomical structure morphogenesis |
TAS | 8823373 |
KRT35 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KRT35 for compounds About GeneDecksing
 Browse Tocris compounds for KRT35
1 Novoseek chemical compound relationship for KRT35 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| paraffin |
46.4 |
1 |
11359384 (1) |
Search CenterWatch for drugs/clinical trials and news about KRT35
|
Transcripts
for KRT35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT35 gene: NM_002280.4 Unigene Cluster for KRT35: Keratin 35 Hs.73082 [show with all ESTs]Unigene Representative Sequence: NM_0022802 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246639(uc002hws.3) ENST00000393989
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT35 (NM_002280) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT35 |
Additional cDNA sequence: X90763.1 5 DOTS entries: DT.92415997 DT.102839922 DT.75138166 DT.97821946 DT.91731610 9 AceView cDNA sequences: NM_002280 AI140753 X90763 AI141038 BG994345 BG980354 BG197371 BQ320877 BQ320753
GeneLoc Exon Structure
|
Expression
for KRT35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTAAAGTT
About this image
See KRT35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT35
SOURCE GeneReport for Unigene cluster: Hs.73082
UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764Tissue specificity: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost corticalcells of the hair bulb
SABiosciences Custom PCR Arrays for KRT35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT35 |
Orthologs
for KRT35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT35 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KRT35 (if available)
TreeFam Gene Tree for KRT35 (if available) |
Paralogs
for KRT35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT35 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT392 KRT402 BFSP22 KRT372
- KRT322 KRT382 KRT362 KRT33B2 KRT33A2
18/46 SIMAP similar genes for KRT35 using alignment to 2 protein entries: KRT35_HUMAN (see all proteins)
(see all similar genes):KRT34 KRT15 KRT36 KRT31 KRT33B KRT19
K14 KRT32 KRT33A keratin JUP KRT16
KRT40 KRT14 KRT39 KRT10 KRT13 KRT20
KRT35 for paralogs About GeneDecksing
|
Genomic Variants
for KRT35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT35 (39632941 - 39637392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT35
2 CNVs: 0205 4036 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KRT35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT35 for disorders About GeneDecksing
OMIM gene information: 602764
OMIM disorders: --
6  diseases for KRT35: About MalaCardsnodular basal cell carcinoma basal cell carcinoma avian influenza influenza
skin cancer carcinoma
Export disorders for KRT35 gene to outside databases
|
Publications
for KRT35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT35 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with KRT35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PubMed id 8823373)1, 2, 3, 9 Rogers M.A.... Schweizer J. (1996)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2 Rogers M.A.... Schweizer J. (1998)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1, 9 Langbein L....Schweizer J. (1999)
- Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. (PubMed id 18021261)1, 9 Gilon M....Gat U. (2008)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
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External Searches for KRT35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT35 gene:
Search GeneIP for patents involving KRT35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT35 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT35 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT35 | | | OriGene Protein Over-expression Lysate for KRT35 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT35 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT35 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT35 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT35 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT35 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT35 |
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 | | | KRT35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT35 |
|  |  |  |  | | | | ThermoFisher Antibodies for KRT35 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT35 |
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