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KRT35 Gene

protein-coding   GIFtS: 49
GCID: GC17M039632

Keratin 35

(Previous names: keratin, hair, acidic, 5)
(Previous symbol: KRTHA5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 351 2     hHa52
KRTHA51 2 3 5     Hard Keratin, Type I, 52
Keratin, Hair, Acidic, 51 2     HHa5 Hair Keratin Type I Intermediate Filament2
Hair Keratin, Type I Ha52 3     Keratin, Type I Cuticular Ha52
K352 3     keratin-352
Hard Keratin Type I 51     HHA53
HA52     HKA53
Ha-52     Keratin-353

External Ids:    HGNC: 64531   Entrez Gene: 38862   Ensembl: ENSG000001970797   OMIM: 6027645   UniProtKB: Q927643   

Export aliases for KRT35 gene to outside databases

Previous GC identifers: GC17M036887 GC17M035396


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT35 Gene:
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic
protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are
clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq,
Jul 2008)

GeneCards Summary for KRT35 Gene:
KRT35 (keratin 35) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT35 gene promoter:
         CHOP-10   p53   Pax-6   ARP-1   Nkx2-5   E47   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT35 promoter sequence
   Search Chromatin IP Primers for KRT35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT35 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039632:  view genomic region     (about GC identifiers)

Start:
39,632,941 bp from pter      End:
39,637,392 bp from pter
Size:
4,452 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764 (See protein sequence)
Recommended Name: Keratin, type I cuticular Ha5  
Size: 455 amino acids; 50361 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Sequence caution: Sequence=CAA62286.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA76387.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O76012 Q92651

Explore the universe of human proteins at neXtProt for KRT35: NX_Q92764

Explore proteomics data for KRT35 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002271.3  
    ENSEMBL proteins: 
     ENSP00000246639   ENSP00000377558  

    KRT35 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q92764

    ProtoNet protein and cluster: Q92764

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT35           About GenesLikeMe


    Animal Models:
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    hsa-miR-203 hsa-miR-205*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005882intermediate filament IEA--

    Find genes that share ontologies with KRT35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT35
    Interactions:

        Search GeneGlobe Interaction Network for KRT35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for KRT35 (Q927643 ENSP000003775584) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    USP15Q9Y4E83, ENSP000002581234I2D: score=1 STRING: ENSP00000258123
    RAB24Q969Q53, ENSP000003043764I2D: score=2 STRING: ENSP00000304376
    CDC25BP303053, ENSP000002459604I2D: score=2 STRING: ENSP00000245960
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS8823373

    Find genes that share ontologies with KRT35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT35

    1 Novoseek inferred chemical compound relationship for KRT35 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 46.4 1 11359384 (1)



    Find genes that share compounds with KRT35           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT35 gene: 
    NM_002280.4  

    Unigene Cluster for KRT35:

    Keratin 35
    Hs.73082  [show with all ESTs]
    Unigene Representative Sequence: NM_002280
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246639(uc002hws.3) ENST00000393989
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate KRT35:
    hsa-miR-203 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidKRT35 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT35
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      QuantiFast Probe-based Assays in human, mouse, rat KRT35

    Additional mRNA sequence: X90763.1 

    5 DOTS entries:

    DT.92415997  DT.102839922  DT.75138166  DT.97821946  DT.91731610 

    9 AceView cDNA sequences:

    NM_002280 X90763 AI141038 AI140753 BG994345 BG980354 BG197371 BQ320753 
    BQ320877 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTAAAGTT
    KRT35 Expression
    About this image


    KRT35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Gut Tube (Gastrointestinal Tract)
             Pharynx
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Placenta (Extraembryonic Tissues)
    KRT35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73082

    UniProtKB/Swiss-Prot: KRT35_HUMAN, Q92764
    Tissue specificity: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost
    cortical cells of the hair bulb

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT35 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt351 , 5 keratin 351, 5 87.62(n)1
    91.21(a)1
      11 (63.40 cM)5
    536171  NM_016880.21  NP_058576.21 
     1000921935 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004917361 keratin, type I cytoskeletal 14-like 61.23(n)
    56.35(a)
      100491736  XM_002939036.2  XP_002939082.2 


    ENSEMBL Gene Tree for KRT35 (if available)
    TreeFam Gene Tree for KRT35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT35 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  
    KRT132  KRT262  KRT102  KRT122  KRT152  KRT242  KRT92  KRT33B2  
    KRT33A2  
    Selected SIMAP similar genes for KRT35 using alignment to 2 protein entries:     KRT35_HUMAN (see all proteins) (see all similar genes):
    KRT34    KRT15    KRT36    KRT31    KRT33B    KRT19
    K14    KRT32    KRT33A    keratin    JUP    KRT16
    KRT40    KRT14    KRT39    KRT10    KRT13    KRT20

    Find genes that share paralogs with KRT35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT35 (see all 236)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423729531,2
    C--35402790(+) TCTTT-/CTTT  
     T
    /TTTTC
    TTTTT
    1 -- us2k10--------
    rs1132935381,2
    C--35402796(+) TTTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs414734481,2
    C,F--39634025(+) AAAAGG/TCTAGA 1 -- int16Minor allele frequency- T:0.17NS EA NA 428
    rs562090451,2
    C--39635519(+) TCCCC-/AATGCT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs58204071,2
    C--39636682(-) GCTGG-/GTAAGC 1 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs671053801,2
    C--39638646(+) CCCCG-/TAAGTC 1 -- us2k10--------
    rs722638231,2
    C--39639182(+) CTTTT-/CTTT/T
    TTC
    /TTTTC
    TTTTT
    1 -- us2k10--------
    rs681091751,2
    C--39639183(+) TTTTT-/TC    
       
    /TTTC
    TTTTT
    1 -- us2k10--------
    rs609945391,2
    C,F--40420024(+) GCTGAA/GCTTGG 1 -- ds50015Minor allele frequency- G:0.26WA NA EA 362
    rs1929193081,2
    --40420111(+) CCTATC/TGCCGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KRT35 (39632941 - 39637392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KRT35:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483014CNV Loss15286789
    nsv510711CNV Loss20534489
    nsv526466CNV Gain19592680
    dgv962e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602764    OMIM disorders: --


    Find genes that share disorders with KRT35           About GenesLikeMe

    Genetic Association Database (GAD): KRT35

    Export disorders for KRT35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT35 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with KRT35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PubMed id 8823373)1, 2, 3, 9 Rogers M.A.... Schweizer J. (J. Invest. Dermatol. 1996)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    3. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2 Rogers M.A.... Schweizer J. (J. Biol. Chem. 1998)
    4. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1, 9 Langbein L....Schweizer J. (J. Biol. Chem. 1999)
    5. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. (PubMed id 18021261)1, 9 Gilon M....Gat U. ( research in biological diversity 2008)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3886 HGNC: 6453 AceView: KRTHA5 Ensembl:ENSG00000197079 euGenes: HUgn3886
    ECgene: KRT35 H-InvDB: KRT35

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KRT35 gene:
    Search GeneIP for patents involving KRT35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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