Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT35 Gene

Aliases for KRT35 Gene

  • Keratin 35 2 3
  • Keratin 35, Type I 2 3 5
  • Keratin, Hair, Acidic, 5 2 3
  • Hair Keratin, Type I Ha5 3 4
  • Keratin-35 3 4
  • KRTHA5 3 4
  • HHa5 3 4
  • K35 3 4
  • HHa5 Hair Keratin Type I Intermediate Filament 3
  • Hard Keratin, Type I, 5 3
  • Hard Keratin Type I 5 2
  • Ha-5 3
  • HKA5 4
  • HA5 3

External Ids for KRT35 Gene

Previous HGNC Symbols for KRT35 Gene

  • KRTHA5

Previous GeneCards Identifiers for KRT35 Gene

  • GC17M036887
  • GC17M039632
  • GC17M035396

Summaries for KRT35 Gene

Entrez Gene Summary for KRT35 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT35 Gene

KRT35 (Keratin 35) is a Protein Coding gene. Diseases associated with KRT35 include Skin Pilomatrix Carcinoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT35 Gene

Genomics for KRT35 Gene

Regulatory Elements for KRT35 Gene

Enhancers for KRT35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT35 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT35 Gene

41,476,689 bp from pter
41,482,743 bp from pter
6,055 bases
Minus strand

Genomic View for KRT35 Gene

Genes around KRT35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT35 Gene

Proteins for KRT35 Gene

  • Protein details for KRT35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha5
    Protein Accession:
    Secondary Accessions:
    • O76012
    • Q92651

    Protein attributes for KRT35 Gene

    455 amino acids
    Molecular mass:
    50361 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    • Sequence=CAA62286.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA76387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KRT35 Gene

Proteomics data for KRT35 Gene at MOPED

Post-translational modifications for KRT35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT35 Gene

Domains & Families for KRT35 Gene

Gene Families for KRT35 Gene

Suggested Antigen Peptide Sequences for KRT35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT35: view

Function for KRT35 Gene

genes like me logo Genes that share phenotypes with KRT35: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT35 Gene

Localization for KRT35 Gene

Subcellular locations from

Jensen Localization Image for KRT35 Gene COMPARTMENTS Subcellular localization image for KRT35 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRT35 Gene

Pathways & Interactions for KRT35 Gene

SuperPathways for KRT35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT35 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT35 Gene

Drugs & Compounds for KRT35 Gene

(1) Additional Compounds for KRT35 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT35: view

Transcripts for KRT35 Gene

mRNA/cDNA for KRT35 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT35 Gene

Keratin 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT35 Gene

No ASD Table

Relevant External Links for KRT35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT35 Gene

mRNA expression in normal human tissues for KRT35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT35 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x40.7) and Skin - Sun Exposed (Lower leg) (x9.1).

Protein differential expression in normal tissues from HIPED for KRT35 Gene

This gene is overexpressed in Hair follicle (54.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT35 Gene

SOURCE GeneReport for Unigene cluster for KRT35 Gene Hs.73082

mRNA Expression by UniProt/SwissProt for KRT35 Gene

Tissue specificity: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.
genes like me logo Genes that share expression patterns with KRT35: view

Protein tissue co-expression partners for KRT35 Gene

Primer Products

Orthologs for KRT35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT35 35
  • 88.57 (n)
  • 89.23 (a)
KRT35 36
  • 89 (a)
(Canis familiaris)
Mammalia KRT35 35
  • 89.52 (n)
  • 90.77 (a)
KRT35 36
  • 91 (a)
(Mus musculus)
Mammalia Krt35 35
  • 87.62 (n)
  • 91.21 (a)
Krt35 16
Krt35 36
  • 91 (a)
(Pan troglodytes)
Mammalia KRT35 35
  • 98.9 (n)
  • 98.9 (a)
KRT35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt35 35
  • 86.67 (n)
  • 90.55 (a)
(Monodelphis domestica)
Mammalia KRT35 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491736 35
  • 61.23 (n)
  • 56.35 (a)
Species with no ortholog for KRT35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT35 Gene

Gene Tree for KRT35 (if available)
Gene Tree for KRT35 (if available)

Paralogs for KRT35 Gene

genes like me logo Genes that share paralogs with KRT35: view

Variants for KRT35 Gene

Sequence variations from dbSNP and Humsavar for KRT35 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs743686 - 41,480,992(+) GCAAG(A/G)GCTGC reference, missense
rs12451652 - 41,477,102(+) GGCTG(C/T)AGTTT reference, missense
rs2071601 - 41,477,097(-) GCAGC(A/C/G)CCCGC reference, missense
rs762825 -- 41,480,343(-) GCCCA(A/C)TCCTC intron-variant
rs762826 -- 41,481,723(-) AGCTG(C/T)CCCAT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KRT35 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
dgv962e1 CNV Complex 17122850
nsv510711 CNV Loss 20534489
nsv526466 CNV Gain 19592680

Variation tolerance for KRT35 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRT35 Gene

Disorders for KRT35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
skin pilomatrix carcinoma
  • malignant pilomatricoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT35 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT35

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT35 Gene

Publications for KRT35 Gene

  1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 1996) 2 3 4 23 67
  2. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. (PMID: 18021261) Gilon M. … Gat U. (Differentiation 2008) 3 23
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  4. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L. … Schweizer J. (J. Biol. Chem. 1999) 3 23
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for KRT35 Gene

Sources for KRT35 Gene