KRT34 Gene
protein-coding GIFtS : 48
GCID: GC17 M039534
keratin 34 (Previous names: keratin, hair, acidic, 4 ) (Previous symbol: KRTHA4 )
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Aliasesfor KRT34 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Keratin 34 1 2 HHa41 KRTHA41 2 3 5 Hard Keratin, Type I, 42 Ha-41 2 Keratin, Type I Cuticular Ha42 Keratin, Hair, Acidic, 41 2 Keratin-343 Hair Keratin, Type I Ha42 3 HHA43 K342 3 HKA43 HA42 5 Keratin-343
Export aliases for KRT34 gene to outside databases Previous GC identifers: GC17M036788 GC17M035298
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Summariesfor KRT34 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KRT34 : The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008) Gene Wiki entry for KRT34 (Keratin 34)
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Genomic Viewsfor KRT34 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KRT34 gene promoter: CREB FAC1 Spz1 Tal-1 Ik-2 Nkx2-5 Msx-1 LyF-1 E47 Other transcription factors Search SABiosciences Chromatin IP Primers for KRT34 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT34
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2 KRT34 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M039534: view genomic region
(about GC identifiers )
Start:
39,533,902 bp from pter
End:
39,538,655 bp from pter
Size:
4,754 bases
Orientation:
minus strand
1 alternative location : Chr 17+,PATCHES 39,510,272-39,514,988
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Proteinsfor KRT34 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KRT34_HUMAN, O76011 (See
protein sequence )Recommended Name: Keratin, type I cuticular Ha4 Size : 436 amino acids; 49424 Da
Miscellaneous : There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Caution : It is uncertain whether Met-1 or Met-43 is the initiator
Sequence caution : Sequence=CAA76386.1; Type=Erroneous initiation;
Secondary accessions : Q8IUT8 Q8N4W2Explore the universe of human proteins at neXtProt for KRT34: NX_O76011 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O76011 KRT34 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_066293.2 ENSEMBL proteins: ENSP00000377570 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005882 intermediate filament
IEA --
KRT34 for ontologies About GeneDecksing KRT34 Antibody Products: Assay Products for KRT34:
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Protein
Domains / Familiesfor KRT34 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KRT34 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O76011 ProtoNet protein and cluster: O76011
2 Blocks protein families : IPB001664 Intermediate filament protein IPB002957 Type I keratin signature UniProtKB/Swiss-Prot: KRT34_HUMAN, O76011 Similarity : Belongs to the intermediate filament family
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Functionfor KRT34 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRT34 (NM_021013 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT34 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT34
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT34
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005198 structural molecule activity
IEA --
KRT34 for ontologies About GeneDecksing
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Pathways & Interactionsfor KRT34 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT34 4 Interacting proteins for KRT34 (O76011 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
KRT34 for ontologies About GeneDecksing
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Drugs & Compoundsfor KRT34 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KRT34 Search CenterWatch for drugs/clinical trials and news about KRT34
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Transcriptsfor KRT34 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KRT34 gene: NM_021013.3 Unigene Cluster for KRT34:
Keratin 34 Hs.296942 [show with all ESTs ] Unigene Representative Sequence: BC041070 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000394001 (uc002hwm.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRT34 (NM_021013 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT34 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT34
Additional cDNA sequence: AF086202.1 BC033252.1 BC041070.1
3 DOTS entries : DT.408285 DT.100737185
DT.91754618 24/76 AceView cDNA sequences (see all 76 ):
BC033252 BF197281 AW069789 NM_021013 NM_004138 BM808576 BM915709 AW169840 BC009971 AJ633621 NM_002279 NM_002277 AA340065 AF086202 BM556055 AI078774 BF569905 BM550495 BM557323 BG118909 BC041070 BM913106 CN479524 BC069135 GeneLoc Exon Structure
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Expression for KRT34 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KRT34 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGCCACCACC
About this image KRT34 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category CD31, CD144 positive cells (Two-step protocol fo... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See KRT34 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KRT34 SOURCE GeneReport for Unigene cluster: Hs.296942 UniProtKB/Swiss-Prot: KRT34_HUMAN, O76011 Tissue specificity : Expressed in the hair follicles SABiosciences Custom PCR Arrays for KRT34 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT34Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KRT34 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT34 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT34 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT34
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Orthologsfor KRT34 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for KRT34 gene from 2/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for KRT34 (if available)TreeFam Gene Tree for KRT34 (if available)
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Paralogsfor KRT34 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KRT34 gene KRT222 2 KRT31 2 ENSG00000264058 2 KRT35 2 KRT39 2 KRT40 2 BFSP2 2 KRT37 2 KRT32 2 KRT38 2 KRT36 2 KRT33B 2 KRT33A 2 18/33 SIMAP similar genes for KRT34 using alignment to 2 protein entries: KRT34_HUMAN (see all proteins )
(see all similar genes ):KRT31 KRT33B KRT33A KRT19 KRT35 KRT36 KRT15 KRT37 KRTHA7 KRT16 KRT14 KRT32 KRT38 JUP KRT20 keratin KRT39 KRT13
KRT34 for paralogs About GeneDecksing
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Genomic Variantsfor KRT34 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KRT34 (39533902 - 39538655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for KRT34 12 CNVs : 37796 30830 88472 4036 9774 0205 9773 77609 67199 88471 35457 77608
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT34
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Disorders
/ Diseasesfor KRT34 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KRT34 for disorders About GeneDecksing
OMIM gene information: 602763
OMIM disorders : --2 diseases for KRT34 : About MalaCards collecting duct carcinoma carcinoma Export disorders for KRT34 gene to outside databases
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Publicationsfor KRT34 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KRT34 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with KRT34) Utopia : connect your pdf to the dynamic world of online information
Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910) 1 , 2 , 3 Rogers M.A.... Schweizer J. (1998) New consensus nomenclature for mammalian keratins. (PubMed id 16831889) 1 , 3 Schweizer J....Wright M.W. (2006) The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PubMed id 2431943) 1 , 3 Heid H.W....Franke W.W. (1986) Expression of cytokeratin 34bE12 is a good indicator o f tumor progression in esophageal squamous cell carcinoma. (PubMed id 22790218) 1 Ono M....Igarashi Y. (2012) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 Sowa M.E....Harper J.W. (2009) Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743) 1 Brehme M....Superti-Furga G. (2009) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 1 Ewing R.M.... Figeys D. (2007) Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma. (PubMed id 16286979) 1 Raica M....Cimpean A.M. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KRT34 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KRT34 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KRT34 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KRT34 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KRT34 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KRT34 gene: Search GeneIP for patents involving KRT34 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KRT34 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for KRT34 OriGene shRNA RFP for KRT34 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KRT34 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT34 OriGene Protein Over-expression Lysate for KRT34 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KRT34 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT34 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KRT34 OriGene Custom Protein Services for KRT34 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT34 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT34 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT34 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KRT34 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT34 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT34
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KRT34 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT34
ThermoFisher Antibodies for KRT34
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT34
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Aliases for KRT34
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