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Aliases for KRT34 Gene

Aliases for KRT34 Gene

  • Keratin 34, Type I 2 3
  • Keratin, Hair, Acidic, 4 2 3
  • Hair Keratin, Type I Ha4 3 4
  • Keratin-34 3 4
  • KRTHA4 3 4
  • HHa4 3 4
  • K34 3 4
  • Hard Keratin, Type I, 4 3
  • Hard Keratin Type I 4 2
  • Keratin 34 2
  • Ha-4 3
  • HKA4 4
  • HA4 3

External Ids for KRT34 Gene

Previous HGNC Symbols for KRT34 Gene

  • KRTHA4

Previous GeneCards Identifiers for KRT34 Gene

  • GC17M036788
  • GC17M039534
  • GC17M035298

Summaries for KRT34 Gene

Entrez Gene Summary for KRT34 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT34 Gene

KRT34 (Keratin 34, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

Gene Wiki entry for KRT34 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT34 Gene

Genomics for KRT34 Gene

Regulatory Elements for KRT34 Gene

Genomic Location for KRT34 Gene

Chromosome:
17
Start:
41,377,650 bp from pter
End:
41,383,816 bp from pter
Size:
6,167 bases
Orientation:
Minus strand

Genomic View for KRT34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT34 Gene

Proteins for KRT34 Gene

  • Protein details for KRT34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76011-KRT34_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha4
    Protein Accession:
    O76011
    Secondary Accessions:
    • Q8IUT8
    • Q8N4W2

    Protein attributes for KRT34 Gene

    Size:
    436 amino acids
    Molecular mass:
    49424 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
    SequenceCaution:
    • Sequence=CAA76386.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KRT34 Gene

Proteomics data for KRT34 Gene at MOPED

Post-translational modifications for KRT34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT34 Gene

Domains & Families for KRT34 Gene

Gene Families for KRT34 Gene

Protein Domains for KRT34 Gene

Suggested Antigen Peptide Sequences for KRT34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76011

UniProtKB/Swiss-Prot:

KRT34_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT34: view

Function for KRT34 Gene

Gene Ontology (GO) - Molecular Function for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT34: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT34

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT34 Gene

Localization for KRT34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT34 Gene COMPARTMENTS Subcellular localization image for KRT34 gene
Compartment Confidence
extracellular 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KRT34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT34 Gene

Pathways & Interactions for KRT34 Gene

SuperPathways for KRT34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9756910
genes like me logo Genes that share ontologies with KRT34: view

No data available for Pathways by source and SIGNOR curated interactions for KRT34 Gene

Drugs & Compounds for KRT34 Gene

No Compound Related Data Available

Transcripts for KRT34 Gene

mRNA/cDNA for KRT34 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT34 Gene

Keratin 34:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT34

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT34 Gene

No ASD Table

Relevant External Links for KRT34 Gene

GeneLoc Exon Structure for
KRT34
ECgene alternative splicing isoforms for
KRT34

Expression for KRT34 Gene

mRNA expression in normal human tissues for KRT34 Gene

mRNA differential expression in normal tissues according to GTEx for KRT34 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.7).

Protein differential expression in normal tissues from HIPED for KRT34 Gene

This gene is overexpressed in Hair follicle (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT34 Gene



SOURCE GeneReport for Unigene cluster for KRT34 Gene Hs.296942

mRNA Expression by UniProt/SwissProt for KRT34 Gene

O76011-KRT34_HUMAN
Tissue specificity: Expressed in the hair follicles.
genes like me logo Genes that share expression patterns with KRT34: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for KRT34 Gene

Orthologs for KRT34 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT34 35
  • 86.19 (n)
  • 84.14 (a)
-- 36
  • 82 (a)
ManyToMany
HKA1 36
  • 84 (a)
ManyToMany
KRT31 36
  • 80 (a)
ManyToMany
KRT33A 36
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Krt34 35
  • 87.59 (n)
  • 87.24 (a)
Krt34 16
Krt31 36
  • 80 (a)
ManyToMany
Krt33a 36
  • 83 (a)
ManyToMany
Krt33b 36
  • 82 (a)
ManyToMany
Krt34 36
  • 87 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia KRT34 35
  • 95.64 (n)
  • 95.18 (a)
rat
(Rattus norvegicus)
Mammalia Krt34 35
  • 87.66 (n)
  • 88.43 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
Species with no ortholog for KRT34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT34 Gene

ENSEMBL:
Gene Tree for KRT34 (if available)
TreeFam:
Gene Tree for KRT34 (if available)

Paralogs for KRT34 Gene

genes like me logo Genes that share paralogs with KRT34: view

Variants for KRT34 Gene

Sequence variations from dbSNP and Humsavar for KRT34 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_056017 -
VAR_056018 -

Structural Variations from Database of Genomic Variants (DGV) for KRT34 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv509656 CNV Insertion 20534489
nsv483014 CNV Loss 15286789
nsv525048 CNV Gain 19592680
nsv817764 CNV Gain 17921354
nsv9554 CNV Gain 18304495
dgv526n67 CNV Gain 20364138
nsv514845 CNV Gain 21397061
nsv499238 CNV Gain 21111241
esv24006 CNV Gain 19812545
nsv513753 CNV Insertion 21212237
nsv442745 CNV CNV 18776908
nsv2052 CNV Insertion 18451855
nsv817765 CNV Gain 17921354

Variation tolerance for KRT34 Gene

Residual Variation Intolerance Score: 95.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.87; 79.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT34 Gene

HapMap Linkage Disequilibrium report
KRT34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT34 Gene

Disorders for KRT34 Gene

Relevant External Links for KRT34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT34
genes like me logo Genes that share disorders with KRT34: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT34 Gene

Publications for KRT34 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 67
  2. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 2 67
  3. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid H.W. … Franke W.W. (Differentiation 1986) 2 67
  4. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 67
  5. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 67

Products for KRT34 Gene

Sources for KRT34 Gene

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