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Aliases for KRT33B Gene

Aliases for KRT33B Gene

  • Keratin 33B 2 3 5
  • Hair Keratin, Type I Ha3-II 3 4
  • Keratin, Hair, Acidic, 3B 2 3
  • Keratin 33B, Type I 2 3
  • HHa3-II 3 4
  • KRTHA3B 3 4
  • K33B 3 4
  • Keratin, Type I Cuticular Ha3-II 3
  • Hard Keratin, Type I, 3II 3
  • Hard Keratin Type I 3II 2
  • Type I Hair Keratin 3B 3
  • Keratin-33B 4
  • KRTHA3A 3
  • Ha-3II 3
  • HA3II 3
  • HKA3B 4

External Ids for KRT33B Gene

Previous HGNC Symbols for KRT33B Gene


Previous GeneCards Identifiers for KRT33B Gene

  • GC17M036774
  • GC17M039519
  • GC17M035284

Summaries for KRT33B Gene

Entrez Gene Summary for KRT33B Gene

  • This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

GeneCards Summary for KRT33B Gene

KRT33B (Keratin 33B) is a Protein Coding gene. Among its related pathways are Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT31.

Gene Wiki entry for KRT33B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT33B Gene

Genomics for KRT33B Gene

Regulatory Elements for KRT33B Gene

Enhancers for KRT33B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F041367 0.6 ENCODE 0.8 +2.0 1974 1.1 JUND KRT38 KRT36 KRT33B KRT33A
GH17F041360 0.2 ENCODE 0.4 +9.0 8994 1.1 JUND ZNF146 ZNF580 FOS KRT34 KRT33A KRT33B
GH17F041377 1.1 Ensembl ENCODE 0.4 -10.2 -10170 5.5 HDAC1 PKNOX1 TBL1XR1 ZFP64 RFX5 ZNF766 GATA2 ZNF680 ZNF654 ZBTB11 KRT34 KRT38 TMEM99 KAT2A KRT32 P3H4 ENSG00000267758 KLHL10 IGFBP4 ENSG00000259623
GH17F041352 0.7 FANTOM5 0.3 +16.6 16642 0.3 ZNF121 MIER1 EHMT2 REST TSHZ1 MAFK ENSG00000259623 KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRT33B on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT33B Gene

41,363,494 bp from pter
41,369,800 bp from pter
6,307 bases
Minus strand

Genomic View for KRT33B Gene

Genes around KRT33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT33B Gene

Proteins for KRT33B Gene

  • Protein details for KRT33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha3-II
    Protein Accession:
    Secondary Accessions:
    • O76010

    Protein attributes for KRT33B Gene

    404 amino acids
    Molecular mass:
    46214 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT33B Gene

Post-translational modifications for KRT33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT33B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT33B Gene

Domains & Families for KRT33B Gene

Gene Families for KRT33B Gene

Suggested Antigen Peptide Sequences for KRT33B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT33B: view

Function for KRT33B Gene

Gene Ontology (GO) - Molecular Function for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT33B: view
genes like me logo Genes that share phenotypes with KRT33B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT33B Gene

Localization for KRT33B Gene

Subcellular locations from

Jensen Localization Image for KRT33B Gene COMPARTMENTS Subcellular localization image for KRT33B gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT33B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT33B Gene

Pathways & Interactions for KRT33B Gene

SuperPathways for KRT33B Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRT33B: view

Pathways by source for KRT33B Gene

1 Reactome pathway for KRT33B Gene

Gene Ontology (GO) - Biological Process for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IDA 21916889
GO:0042633 hair cycle IDA 21916889
genes like me logo Genes that share ontologies with KRT33B: view

No data available for SIGNOR curated interactions for KRT33B Gene

Transcripts for KRT33B Gene

mRNA/cDNA for KRT33B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT33B Gene

Keratin 33B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT33B Gene

No ASD Table

Relevant External Links for KRT33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT33B Gene

mRNA differential expression in normal tissues according to GTEx for KRT33B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.3) and Skin - Sun Exposed (Lower leg) (x5.8).

Protein differential expression in normal tissues from HIPED for KRT33B Gene

This gene is overexpressed in Hair follicle (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT33B Gene

Protein tissue co-expression partners for KRT33B Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT33B Gene:


SOURCE GeneReport for Unigene cluster for KRT33B Gene:

genes like me logo Genes that share expression patterns with KRT33B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRT33B Gene

Orthologs for KRT33B Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT33B 35
  • 99 (a)
(Canis familiaris)
Mammalia -- 35
  • 88 (a)
-- 35
  • 87 (a)
(Mus musculus)
Mammalia Krt33a 35
  • 88 (a)
Krt33b 35
  • 87 (a)
Krt34 35
  • 86 (a)
Krt31 35
  • 85 (a)
(Bos Taurus)
Mammalia -- 35
  • 87 (a)
KRT33A 35
  • 86 (a)
HKA1 35
  • 85 (a)
KRT31 35
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
-- 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
-- 35
  • 79 (a)
-- 35
  • 79 (a)
Species where no ortholog for KRT33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT33B Gene

Gene Tree for KRT33B (if available)
Gene Tree for KRT33B (if available)

Paralogs for KRT33B Gene Pseudogenes for KRT33B Gene

genes like me logo Genes that share paralogs with KRT33B: view

Variants for KRT33B Gene

Sequence variations from dbSNP and Humsavar for KRT33B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10852944 -- 41,371,614(+) CTTTC(C/T)GCCCC upstream-variant-2KB
rs111431474 -- 41,366,907(+) GCTGC(C/T)TTTGC intron-variant
rs111508749 -- 41,370,372(+) ACCCA(C/T)CTCCG upstream-variant-2KB
rs111589738 -- 41,368,071(+) TCAGC(C/G/T)ACATT intron-variant
rs111595732 -- 41,371,413(+) ATAGC(-/ATCTT)TAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT33B Gene

Variant ID Type Subtype PubMed ID
dgv23n64 CNV loss 17921354
dgv3171n100 CNV loss 25217958
dgv3172n100 CNV loss 25217958
dgv3173n100 CNV loss 25217958
esv2422104 CNV deletion 20811451
esv25327 CNV loss 19812545
esv2671270 CNV deletion 23128226
esv2758690 CNV gain+loss 17122850
esv2760456 CNV gain+loss 21179565
esv2762377 CNV loss 21179565
esv3640584 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv1160486 CNV duplication 26073780
nsv2051 CNV deletion 18451855
nsv438274 CNV loss 16468122
nsv442744 CNV loss 18776908
nsv457741 CNV loss 19166990
nsv483014 CNV loss 15286789
nsv509656 CNV insertion 20534489
nsv514844 CNV loss 21397061
nsv516965 CNV loss 19592680
nsv518572 CNV loss 19592680
nsv526464 CNV gain 19592680
nsv575036 CNV loss 21841781
nsv9553 CNV loss 18304495
nsv960103 CNV duplication 23825009
nsv960488 CNV duplication 23825009
nsv960601 CNV deletion 23825009

Variation tolerance for KRT33B Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT33B Gene

Disorders for KRT33B Gene

Relevant External Links for KRT33B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT33B Gene

Publications for KRT33B Gene

  1. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PMID: 7565656) Rogers M.A. … Winter H. (Mol. Biol. Rep. 1994) 2 3 4 64
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 3 4 64
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3 64

Products for KRT33B Gene

Sources for KRT33B Gene

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