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Aliases for KRT33B Gene

Aliases for KRT33B Gene

  • Keratin 33B, Type I 2 3
  • Hair Keratin, Type I Ha3-II 3 4
  • Keratin, Hair, Acidic, 3B 2 3
  • KRTHA3A 3 6
  • HHa3-II 3 4
  • KRTHA3B 3 4
  • HA3II 3 6
  • K33B 3 4
  • Keratin, Type I Cuticular Ha3-II 3
  • Hard Keratin, Type I, 3II 3
  • Hard Keratin Type I 3II 2
  • Type I Hair Keratin 3B 3
  • Keratin 33B 2
  • Keratin-33B 4
  • Ha-3II 3
  • HKA3B 4

External Ids for KRT33B Gene

Previous HGNC Symbols for KRT33B Gene


Previous GeneCards Identifiers for KRT33B Gene

  • GC17M036774
  • GC17M039519
  • GC17M035284

Summaries for KRT33B Gene

Entrez Gene Summary for KRT33B Gene

  • This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

GeneCards Summary for KRT33B Gene

KRT33B (Keratin 33B, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT33B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT33B Gene

Genomics for KRT33B Gene

Regulatory Elements for KRT33B Gene

Genomic Location for KRT33B Gene

41,363,494 bp from pter
41,397,592 bp from pter
34,099 bases
Minus strand

Genomic View for KRT33B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT33B Gene

Proteins for KRT33B Gene

  • Protein details for KRT33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha3-II
    Protein Accession:
    Secondary Accessions:
    • O76010

    Protein attributes for KRT33B Gene

    404 amino acids
    Molecular mass:
    46214 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT33B Gene

Proteomics data for KRT33B Gene at MOPED

Post-translational modifications for KRT33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT33B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT33B Gene

Domains for KRT33B Gene

Gene Families for KRT33B Gene

  • IFF1 :Intermediate filaments type I, keratins (acidic)

Protein Domains for KRT33B Gene

Suggested Antigen Peptide Sequences for KRT33B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14525
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT33B: view

Function for KRT33B Gene

Gene Ontology (GO) - Molecular Function for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT33B: view

Phenotypes for KRT33B Gene

GenomeRNAi human phenotypes for KRT33B:
genes like me logo Genes that share phenotypes with KRT33B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT33B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT33B Gene

Localization for KRT33B Gene

Subcellular locations from

Jensen Localization Image for KRT33B Gene COMPARTMENTS Subcellular localization image for KRT33B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT33B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT33B Gene

Pathways for KRT33B Gene

SuperPathways for KRT33B Gene

No Data Available

Interacting Proteins for KRT33B Gene

Gene Ontology (GO) - Biological Process for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IDA 21916889
GO:0042633 hair cycle IDA 21916889
genes like me logo Genes that share ontologies with KRT33B: view

No data available for Pathways by source for KRT33B Gene

Transcripts for KRT33B Gene

mRNA/cDNA for KRT33B Gene

(76) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT33B Gene

Keratin 33B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT33B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT33B Gene

No ASD Table

Relevant External Links for KRT33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT33B Gene

mRNA expression in normal human tissues for KRT33B Gene

mRNA differential expression in normal tissues according to GTEx for KRT33B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (46.3) and Skin - Sun Exposed (Lower leg) (5.8).

Protein differential expression in normal tissues for KRT33B Gene

This gene is overexpressed in Hair follicle (68.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT33B Gene

SOURCE GeneReport for Unigene cluster for KRT33B Gene Hs.32950

genes like me logo Genes that share expressions with KRT33B: view

Expression partners for KRT33B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRT33B Gene

Orthologs for KRT33B Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT33B Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Krt33b 16
Krt31 36
  • 85 (a)
Krt33a 36
  • 88 (a)
Krt33b 36
  • 87 (a)
Krt34 36
  • 86 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
HKA1 36
  • 85 (a)
KRT31 36
  • 83 (a)
KRT33A 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
-- 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
-- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 79 (a)
-- 36
  • 79 (a)
(Pan troglodytes)
Mammalia KRT33B 36
  • 99 (a)
Species with no ortholog for KRT33B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT33B Gene

Gene Tree for KRT33B (if available)
Gene Tree for KRT33B (if available)

Paralogs for KRT33B Gene Pseudogenes for KRT33B Gene

genes like me logo Genes that share paralogs with KRT33B: view

Variants for KRT33B Gene

Sequence variations from dbSNP and Humsavar for KRT33B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2285672 -- 41,363,749(-) CCACC(A/G)GACCC utr-variant-3-prime
rs2522040 -- 41,368,926(-) GGACC(A/T)TCCTC intron-variant
rs2522041 -- 41,364,485(-) AAAAA(A/G)GAAAA intron-variant
rs2857622 -- 41,368,925(-) GACCT(A/T)CCTCT intron-variant
rs2857623 -- 41,364,491(-) CAACA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT33B Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv518572 CNV Loss 19592680
nsv509656 CNV Insertion 20534489
nsv483014 CNV Loss 15286789
nsv2051 CNV Loss 18451855
nsv9553 CNV Loss 18304495
nsv514844 CNV Loss 21397061
esv2671270 CNV Deletion 23128226
esv25327 CNV Loss 19812545
esv2422104 CNV Deletion 20811451
nsv457741 CNV Loss 19166990
nsv516965 CNV Loss 19592680
dgv23n64 CNV Loss 17921354
nsv442744 CNV CNV 18776908
nsv438274 CNV Loss 16468122
nsv526464 CNV Gain 19592680

Relevant External Links for KRT33B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT33B Gene

Disorders for KRT33B Gene

No disorders were found for KRT33B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRT33B Gene

Publications for KRT33B Gene

  1. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PMID: 7565656) Rogers M.A. … Winter H. (Mol. Biol. Rep. 1994) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 3 4
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for KRT33B Gene

Sources for KRT33B Gene

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