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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT33B Gene

protein-coding   GIFtS: 47
GCID: GC17M039519

Keratin 33B

(Previous names: keratin, hair, acidic, 3B)
(Previous symbol: KRTHA3B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 33B1 2     Ha-3II2
KRTHA3B1 2 3     hHa3-II2
Keratin, Hair, Acidic, 3B1 2     Hard Keratin, Type I, 3II2
Hair Keratin, Type I Ha3-II2 3     Keratin, Type I Cuticular Ha3-II2
K33B2 3     Type I Hair Keratin 3B2
HA3II2 5     HHA3-II3
KRTHA3A2 5     HKA3B3
Hard Keratin Type I 3II1     Keratin-33B3

External Ids:    HGNC: 64511   Entrez Gene: 38842   Ensembl: ENSG000001317387   OMIM: 6027625   UniProtKB: Q145253   

Export aliases for KRT33B gene to outside databases

Previous GC identifers: GC17M036774 GC17M035284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT33B Gene:
This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that
are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair
keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and
nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B.
(provided by RefSeq, May 2012)

GeneCards Summary for KRT33B Gene: 
KRT33B (keratin 33B) is a protein-coding gene. Diseases associated with KRT33B include alopecia. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT33B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT33B gene promoter:
         Spz1   Tal-1   Nkx2-5   Nkx5-1   AP-2gamma   E47   Ik-2   Msx-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT33B promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT33B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT33B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT33B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039519:  view genomic region     (about GC identifiers)

Start:
39,519,746 bp from pter      End:
39,526,052 bp from pter
Size:
6,307 bases      Orientation:
minus strand

1 alternative location:
Chr17+,NW_003315953 70,466-76,767     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KT33B_HUMAN, Q14525 (See protein sequence)
Recommended Name: Keratin, type I cuticular Ha3-II  
Size: 404 amino acids; 46214 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: O76010

Explore the universe of human proteins at neXtProt for KRT33B: NX_Q14525

Explore proteomics data for KRT33B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14525

  • KRT33B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT33B Protein Expression
    REFSEQ proteins: NP_002270.1  
    ENSEMBL proteins: 
     ENSP00000251646  

    Human Recombinant Protein Products for KRT33B: 
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    Cloud-Clone Corp. Proteins for KRT33B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    KRT33B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q14525

    ProtoNet protein and cluster: Q14525

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: KT33B_HUMAN, Q14525
    Similarity: Belongs to the intermediate filament family


    KRT33B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT33B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT33B:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT33B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/16 Interacting proteins for KRT33B (Q145253 ENSP000002516464) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFHD1Q9BUP03, ENSP000002640594I2D: score=1 STRING: ENSP00000264059
    OTUD4Q018043, ENSP000004092794I2D: score=2 STRING: ENSP00000409279
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    RAB24Q969Q53, ENSP000003043764I2D: score=2 STRING: ENSP00000304376
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT33B (KT33B)

    Search CenterWatch for drugs/clinical trials and news about KRT33B / KT33B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT33B gene: 
    NM_002279.4  

    Unigene Cluster for KRT33B:

    Keratin 33B
    Hs.32950  [show with all ESTs]
    Unigene Representative Sequence: NM_002279
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000251646(uc002hwl.3)
    miRNA
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    hsa-miR-561 hsa-miR-450b-5p hsa-miR-4273 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidKRT33B 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT33B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT33B

    Additional mRNA sequence: 

    BC009971.2 X82634.1 

    2 DOTS entries:

    DT.455054  DT.102820100 

    24/76 AceView cDNA sequences (see all 76):

    AW069789 AA340065 NM_002279 NM_004138 AF086202 AJ633621 BM915709 BM808576 
    AW169840 BC009971 BC033252 BF197281 NM_021013 NM_002277 CN479524 BM550495 
    BQ184057 BM559828 BF569905 BM009783 BC041070 AA326093 BM423546 CB111679 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT33B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGGAAGG
    KRT33B Expression
    About this image


    See KRT33B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT33B

    SOURCE GeneReport for Unigene cluster: Hs.32950
        SABiosciences Custom PCR Arrays for KRT33B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT33B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KRT33B gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt33b1 , 5 keratin 33B1, 5 87.43(n)1
    87.1(a)1
      11 (63.37 cM)5
    166711  NM_013570.11  NP_038598.11 
     1000236345 


    ENSEMBL Gene Tree for KRT33B (if available)
    TreeFam Gene Tree for KRT33B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT33B gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT132  
    KRT262  KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33A2  
    18/37 SIMAP similar genes for KRT33B using alignment to 1 protein entry:     KT33B_HUMAN(see all similar genes):
    KRT33A    KRT31    KRT34    KRT19    KRT15    KRT32
    KRT35    KRT36    KRT37    KRT38    KRTHA7    KRT16
    KRT13    KRT14    KRT20    KRT40    JUP    KRT9

    KRT33B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT33B
    PGOHUM00000239980


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 SNPs in KRT33B are shown (see all 258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800350091,2
    C,F--35283331(+) CACCTC/TGTATG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs22856721,2
    C,F,H--35283503(-) CCACCG/AGACCC 1 -- ut31 ese311Minor allele frequency- A:0.03EA NS 2242
    rs1506207281,2
    C,F--39520119(+) CACAGC/TGGGAA 4 H R mis11Minor allele frequency- T:0.00NA 4544
    rs1397412541,2
    C--39520120(+) ACAGCG/AGGAAC 4 /R /C mis11Minor allele frequency- A:0.00NA 4544
    rs1463493341,2
    C--39520158(+) ATCCAA/GTGGGC 4 T I mis11Minor allele frequency- G:0.00NA 4544
    rs789319011,2
    C--39520360(+) TGATAC/TAGTGG 2 -- int14Minor allele frequency- T:0.04NA WA EA 360
    rs1414432441,2
    C--39520539(+) AAAAA-/TATTATGT 2 -- int10--------
    rs351420241,2
    C,F--39520892(+) TCCTAC/TACTTC 2 -- int112Minor allele frequency- T:0.13NA EA CSA WA 732
    rs169667381,2
    C,F,H--39521015(+) TGCCGT/CCCGCC 2 -- int122Minor allele frequency- C:0.14NA NS EA CSA WA 2256
    rs617416601,2
    C,F--39521045(+) TCGCTC/TTCCAG 4 E syn13Minor allele frequency- T:0.01NS NA EU 5933

    HapMap Linkage Disequilibrium report for KRT33B (39519746 - 39526052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for KRT33B (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671270CNV Deletion23128226
    esv2422104CNV Deletion20811451
    nsv509656CNV Insertion20534489
    nsv2051CNV Loss18451855
    dgv23n64CNV Loss17921354
    nsv483014CNV Loss15286789
    nsv457741CNV Loss19166990
    nsv518572CNV Loss19592680
    esv25327CNV Loss19812545
    nsv9553CNV Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602762    OMIM disorders: --

    2 diseases for KRT33B:    About MalaCards
    alopecia    


    KRT33B for disorders           About GeneDecksing


    Export disorders for KRT33B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT33B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with KRT33B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PubMed id 7565656)1, 2, 3 Rogers M.A.... Winter H. (1994)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2 Rogers M.A.... Schweizer J. (1998)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    6. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3884 HGNC: 6451 AceView: KRTHA_ Ensembl:ENSG00000131738 euGenes: HUgn3884
    ECgene: KRT33B H-InvDB: KRT33B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT33B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT33B gene:
    Search GeneIP for patents involving KRT33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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