Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT33A Gene

Aliases for KRT33A Gene

  • Keratin 33A 2 3 5
  • Hair Keratin, Type I Ha3-I 3 4
  • Keratin, Hair, Acidic, 3A 2 3
  • Keratin 33A, Type I 2 3
  • KRTHA3A 3 4
  • HHa3-I 3 4
  • K33A 3 4
  • Keratin, Type I Cuticular Ha3-I 3
  • Hard Keratin, Type I,3I 3
  • Hard Keratin Type I 3I 2
  • Keratin-33A 4
  • Krt1-3 3
  • Ha-3I 3
  • HKA3A 4
  • HA3I 3

External Ids for KRT33A Gene

Previous HGNC Symbols for KRT33A Gene


Previous GeneCards Identifiers for KRT33A Gene

  • GC17M036756
  • GC17M039502
  • GC17M035265

Summaries for KRT33A Gene

Entrez Gene Summary for KRT33A Gene

  • This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

GeneCards Summary for KRT33A Gene

KRT33A (Keratin 33A) is a Protein Coding gene. Among its related pathways are Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT31.

Gene Wiki entry for KRT33A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT33A Gene

Genomics for KRT33A Gene

Regulatory Elements for KRT33A Gene

Enhancers for KRT33A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F041352 0.7 FANTOM5 0.8 -2.3 -2347 0.3 ZNF121 MIER1 EHMT2 REST TSHZ1 MAFK ENSG00000259623 KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35
GH17F041347 0.2 ENCODE 0.8 +2.4 2388 1.0 KRT38 KRT31 KRT33A ENSG00000108516
GH17F041338 1 Ensembl ENCODE 0.4 +9.8 9801 6.0 PKNOX1 MTA2 YBX1 EBF1 TBX21 RELA GATA3 NBN PRDM1 KRT38 KRTAP16-1 KRTAP29-1 KRT31 LOC100505782 KRTAP17-1 KRTAP9-6 KRT37 ENSG00000234477 KRT32
GH17F041360 0.2 ENCODE 0.4 -10.0 -9995 1.1 JUND ZNF146 ZNF580 FOS KRT34 KRT33A KRT33B
GH17F041336 0.5 ENCODE 0.4 +14.6 14569 0.2 NRF1 KRTAP29-1 KRTAP16-1 KRTAP17-1 KRTAP9-6 KRT37 KRT31 LOC100505782 ENSG00000234477 KRT32 RNU2-32P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRT33A on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT33A Gene

41,345,705 bp from pter
41,350,812 bp from pter
5,108 bases
Minus strand

Genomic View for KRT33A Gene

Genes around KRT33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT33A Gene

Proteins for KRT33A Gene

  • Protein details for KRT33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha3-I
    Protein Accession:
    Secondary Accessions:
    • B2RA87
    • Q6NTB9
    • Q6ZZB9

    Protein attributes for KRT33A Gene

    404 amino acids
    Molecular mass:
    45940 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT33A Gene

Post-translational modifications for KRT33A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT33A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT33A Gene

Domains & Families for KRT33A Gene

Gene Families for KRT33A Gene

Suggested Antigen Peptide Sequences for KRT33A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT33A: view

Function for KRT33A Gene

Gene Ontology (GO) - Molecular Function for KRT33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT33A: view
genes like me logo Genes that share phenotypes with KRT33A: view

Animal Model Products

miRNA for KRT33A Gene

miRTarBase miRNAs that target KRT33A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT33A Gene

Localization for KRT33A Gene

Subcellular locations from

Jensen Localization Image for KRT33A Gene COMPARTMENTS Subcellular localization image for KRT33A gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT33A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT33A Gene

Pathways & Interactions for KRT33A Gene

SuperPathways for KRT33A Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRT33A: view

Pathways by source for KRT33A Gene

1 Reactome pathway for KRT33A Gene

Gene Ontology (GO) - Biological Process for KRT33A Gene


No data available for SIGNOR curated interactions for KRT33A Gene

Transcripts for KRT33A Gene

mRNA/cDNA for KRT33A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT33A Gene

Keratin 33A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT33A Gene

No ASD Table

Relevant External Links for KRT33A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT33A Gene

mRNA expression in normal human tissues for KRT33A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT33A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x44.8) and Skin - Sun Exposed (Lower leg) (x5.7).

Protein differential expression in normal tissues from HIPED for KRT33A Gene

This gene is overexpressed in Hair follicle (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT33A Gene

Protein tissue co-expression partners for KRT33A Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT33A Gene:


SOURCE GeneReport for Unigene cluster for KRT33A Gene:


mRNA Expression by UniProt/SwissProt for KRT33A Gene:

Tissue specificity: Expressed in the hair follicles.
genes like me logo Genes that share expression patterns with KRT33A: view

Primer Products

Orthologs for KRT33A Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT33A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT33A 34 35
  • 98.84 (n)
(Bos Taurus)
Mammalia KRT33A 35
  • 89 (a)
LOC618455 34
  • 88.68 (n)
-- 35
  • 87 (a)
HKA1 35
  • 86 (a)
KRT31 35
  • 83 (a)
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
-- 35
  • 88 (a)
(Mus musculus)
Mammalia Krt33a 35
  • 89 (a)
Krt33b 35
  • 87 (a)
Krt34 35
  • 87 (a)
Krt31 35
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
-- 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
-- 35
  • 80 (a)
-- 35
  • 80 (a)
Species where no ortholog for KRT33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT33A Gene

Gene Tree for KRT33A (if available)
Gene Tree for KRT33A (if available)

Paralogs for KRT33A Gene

Variants for KRT33A Gene

Sequence variations from dbSNP and Humsavar for KRT33A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193921001 Uncertain significance 41,350,553(-) CCTGG(A/G)GAAGG upstream-variant-2KB, reference, missense
rs111487509 -- 41,350,654(+) TTGGC(A/G)GGGAT upstream-variant-2KB, reference, synonymous-codon
rs111522412 -- 41,347,042(+) GTGGC(C/G)ACGTG intron-variant
rs111795550 -- 41,350,606(+) TCACT(A/G)CCATT upstream-variant-2KB, reference, synonymous-codon
rs111829803 -- 41,351,018(+) AAGTC(A/G)GGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT33A Gene

Variant ID Type Subtype PubMed ID
dgv3171n100 CNV loss 25217958
esv25327 CNV loss 19812545
esv2671270 CNV deletion 23128226
esv2758690 CNV gain+loss 17122850
esv3640584 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv2051 CNV deletion 18451855
nsv483014 CNV loss 15286789
nsv509656 CNV insertion 20534489
nsv514844 CNV loss 21397061
nsv518572 CNV loss 19592680
nsv9553 CNV loss 18304495
nsv962321 CNV duplication 23825009

Variation tolerance for KRT33A Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.21; 92.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT33A Gene

Disorders for KRT33A Gene

Relevant External Links for KRT33A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT33A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT33A Gene

Publications for KRT33A Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4 64
  3. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers M.A. … Schweizer J. (J. Biol. Chem. 1998) 3 4 64
  4. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PMID: 7565656) Rogers M.A. … Winter H. (Mol. Biol. Rep. 1994) 2 3 64
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3 64

Products for KRT33A Gene

Sources for KRT33A Gene

Loading form....