KRT33A Gene
protein-coding GIFtS: 45
GCID: GC17M039502
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|
keratin 33A(Previous names: keratin, hair, acidic, 3A )
(Previous symbol: KRTHA3A)
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Aliases
for KRT33A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 33A1 2 | | HA3I2 5 | | KRTHA3A1 2 3 5 | | HHa3-I1 | | Ha-3I1 2 | | Hard Keratin, Type I,3I2 | | Krt1-31 2 | | Keratin, Type I Cuticular Ha3-I2 | | Keratin, Hair, Acidic, 3A1 2 | | HHA3-I3 | | Hair Keratin, Type I Ha3-I2 3 | | HKA3A3 | | K33A2 3 | | Keratin-33A3 |
Export aliases for KRT33A gene to outside databasesPrevious GC identifers: GC17M036756 GC17M035265 |
Summaries
for KRT33A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT33A:
This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that areclustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin,the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There aretwo isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. (provided by RefSeq, May2012)
Gene Wiki entry for KRT33A
|
Genomic Views
for KRT33A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT33A gene promoter:
Tal-1 p300 Nkx2-5 AP-2gamma Meis-1b E47 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT33A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT33A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRT33A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039502: view genomic region
(about GC identifiers)
Start:
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39,502,344 bp from pter |
End:
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39,507,064 bp from pter |
Size:
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4,721 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17+,PATCHES 39,549,156-39,553,841 |
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Proteins
for KRT33A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KT33A_HUMAN, O76009 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha3-I Size: 404 amino acids; 45940 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: B2RA87 Q6NTB9 Q6ZZB9Explore the universe of human proteins at neXtProt for KRT33A: NX_O76009
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76009
KRT33A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004129.2
ENSEMBL proteins: ENSP00000007735
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT33A for ontologies About GeneDecksing
KRT33A Antibody Products:
Assay Products for KRT33A: |
Protein
Domains /
Families
for KRT33A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT33A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76009ProtoNet protein and cluster: O76009 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: KT33A_HUMAN, O76009Similarity: Belongs to the intermediate filament family |
Function
for KRT33A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT33A for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for KRT33A:
Animal Models:
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Krt33a):
KRT33A for phenotypes About GeneDecksing
|
Pathways & Interactions
for KRT33A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT33A
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for KRT33A (O760093 ENSP000000077354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRT33A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT33A
Search CenterWatch for drugs/clinical trials and news about KRT33A / KT33A
|
Transcripts
for KRT33A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT33A gene: NM_004138.3 Unigene Cluster for KRT33A: Keratin 33A Hs.512579 Unigene Representative Sequence: AK3140881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000007735(uc002hwk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT33A (NM_004138) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT33A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT33A |
Additional cDNA sequence: AJ633621.2 AK314088.1 BC069135.1 1 DOTS entry: DT.102820100 24/76 AceView cDNA sequences (see all 76): AJ633621 BF197281 AW169840 BC033252 AW069789 AA340065 AF086202 NM_004138 BM808576 NM_021013 BM915709 NM_002277 BC009971 NM_002279 AI827418 W48785 CB150240 BM911724 BM913326 BM556236 X82634 BM913106 CN479524 BF569905
GeneLoc Exon Structure
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Expression
for KRT33A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT33A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACAAGTCC
About this image
See KRT33A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT33A
SOURCE GeneReport for Unigene cluster: Hs.512579
UniProtKB/Swiss-Prot: KT33A_HUMAN, O76009Tissue specificity: Expressed in the hair follicles
SABiosciences Custom PCR Arrays for KRT33A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT33A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT33A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT33A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT33A |
Orthologs
for KRT33A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT33A gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for KRT33A (if available)
TreeFam Gene Tree for KRT33A (if available) |
Paralogs
for KRT33A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT33A gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22
- KRT372 KRT322 KRT382 KRT362 KRT33B2
18/40 SIMAP similar genes for KRT33A using alignment to 1 protein entry: KT33A_HUMAN(see all similar genes):KRT33B KRT31 KRT34 KRT19 JUP KRT15
KRT32 KRT14 KRT16 KRT35 KRT36 KRT37
KRT38 KRT20 KRTHA7 keratin KRT40 KRT13
KRT33A for paralogs About GeneDecksing
|
Genomic Variants
for KRT33A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT33A (39502344 - 39507064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KRT33A
8 CNVs: 67198 0205 88470 77607 88468 35456 88469 4036 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT33A |
|
Disorders
/ Diseases
for KRT33A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT33A for disorders About GeneDecksing
OMIM gene information: 602761
OMIM disorders: --
1  disease for KRT33A: About MalaCardsintraepithelial neoplasm
Export disorders for KRT33A gene to outside databases
|
Publications
for KRT33A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT33A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KRT33A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2 Rogers M.A.... Schweizer J. (1998)
- A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PubMed id 7565656)1, 3 Rogers M.A.... Winter H. (1994)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1 Langbein L....Schweizer J. (1999)
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External Searches for KRT33A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT33A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT33A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT33A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT33A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT33A gene:
Search GeneIP for patents involving KRT33A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT33A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT33A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT33A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT33A | | | OriGene Protein Over-expression Lysate for KRT33A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT33A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT33A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KRT33A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for KRT33A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT33A |
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