KRT32 Gene
protein-coding GIFtS: 47
GCID: GC17M039615
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keratin 32(Previous names: keratin, hair, acidic, 2 )
(Previous symbol: KRTHA2)
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Aliases
for KRT32 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 321 2 | | HHa21 | | KRTHA21 2 3 5 | | Hard Keratin, Type I, 22 | | Keratin, Hair, Acidic, 21 2 | | Keratin, Type I Cuticular Ha22 | | Hair Keratin, Type I Ha22 3 | | Keratin-323 | | HKA22 3 | | Type I Cuticular Hair Keratin2 | | K322 3 | | HHA23 | | HA22 5 | | Keratin-323 | | Ha-21 | | |
Export aliases for KRT32 gene to outside databasesPrevious GC identifers: GC17M036870 GC17M035379 |
Summaries
for KRT32 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT32:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidicprotein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered ina region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
Gene Wiki entry for KRT32
|
Genomic Views
for KRT32 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT32 gene promoter:
CHOP-10 ARP-1 Nkx2-5 CUTL1 Tal-1beta E47 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT32
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT32 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KRT32 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039615: view genomic region
(about GC identifiers)
Start:
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39,615,765 bp from pter |
End:
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39,623,681 bp from pter |
Size:
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7,917 bases |
Orientation:
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minus strand |
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Proteins
for KRT32 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K1H2_HUMAN, Q14532 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha2 Size: 448 amino acids; 50343 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Sequence caution: Sequence=CAA57179.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Explore the universe of human proteins at neXtProt for KRT32: NX_Q14532
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14532
KRT32 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002269.3
ENSEMBL proteins: ENSP00000225899
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT32 for ontologies About GeneDecksing
KRT32 Antibody Products:
Assay Products for KRT32: |
Protein
Domains /
Families
for KRT32 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT32 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14532ProtoNet protein and cluster: Q14532 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1H2_HUMAN, Q14532Similarity: Belongs to the intermediate filament family |
Function
for KRT32 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KRT32 (NM_002278) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT32 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT32 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT32 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT32 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT32:
|
Pathways & Interactions
for KRT32 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT32
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for KRT32 (Q145323 ENSP000002258994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
KRT32 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT32 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT32
Search CenterWatch for drugs/clinical trials and news about KRT32 / K1H2
|
Transcripts
for KRT32 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT32 gene: NM_002278.3 Unigene Cluster for KRT32: Keratin 32 Hs.41752 [show with all ESTs]Unigene Representative Sequence: NM_0022781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000225899(uc002hwr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT32 (NM_002278) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT32 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT32 |
Additional cDNA sequence: X81419.1 5 DOTS entries: DT.203153 DT.95369736 DT.91731610 DT.95306117 DT.95136908 18 AceView cDNA sequences: AI190798 X81419 AI080157 NM_002278 BF873748 BF873743 BF760120 BQ330724 BF874170 BF874171 BF873746 AI081886 BF874183 BG953695 BF873751 BF871251 BQ330723 BF755888
GeneLoc Exon Structure
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Expression
for KRT32 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KRT32 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT32
SOURCE GeneReport for Unigene cluster: Hs.41752
UniProtKB/Swiss-Prot: K1H2_HUMAN, Q14532Tissue specificity: Restricted to the hair cuticle
SABiosciences Custom PCR Arrays for KRT32
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT32
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT32 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT32 |
Orthologs
for KRT32 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT32 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KRT32 (if available)
TreeFam Gene Tree for KRT32 (if available) |
Paralogs
for KRT32 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT32 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22
- KRT372 KRT382 KRT362 KRT33B2 KRT33A2
18/33 SIMAP similar genes for KRT32 using alignment to 1 protein entry: K1H2_HUMAN(see all similar genes):KRT31 KRT33B KRT33A KRT15 KRT35 KRT19
KRT34 KRT17 KRT36 KRT14 KRT20 JUP
KRT10 KRT12 KRT37 KRTHA7 KRT9 KRT13
KRT32 for paralogs About GeneDecksing
|
Genomic Variants
for KRT32 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT32 (39615765 - 39623681 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT32
2 CNVs: 0205 4036 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KRT32 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KRT32 for disorders About MalaCards
KRT32 for disorders About GeneDecksing
OMIM gene information: 602760
OMIM disorders: --
Export disorders for KRT32 gene to outside databases
|
Publications
for KRT32 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT32 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT32) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PubMed id 8823373)1, 2, 3, 9 Rogers M.A.... Schweizer J. (1996)
- Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PubMed id 7556444)1, 2, 3 Rogers M.A.... Schweizer J. (1995)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1, 9 Langbein L....Schweizer J. (1999)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. (PubMed id 12543931)1 Adkins J.N....Pounds J.G. (2002)
- Human hair keratins. (PubMed id 7686952)1 Yu J....Bertolino A.P. (1993)
- Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles. (PubMed id 2456239)1 Heid H.W....Franke W.W. (1988)
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External Searches for KRT32 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT32 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT32 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT32 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT32 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT32 gene:
Search GeneIP for patents involving KRT32
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT32 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT32 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT32 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT32 | | | OriGene Protein Over-expression Lysate for KRT32 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT32 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT32 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KRT32 | | OriGene Custom Protein Services for KRT32 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT32 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT32 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT32 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT32 |
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| | | | Search Tocris compounds for KRT32 |
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 | | | KRT32 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT32 |
|  |  |  | | | | ThermoFisher Antibodies for KRT32 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT32 |
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