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Aliases for KRT32 Gene

Aliases for KRT32 Gene

  • Keratin 32, Type I 2 3
  • KRTHA2 3 4 6
  • Keratin, Hair, Acidic, 2 2 3
  • Hair Keratin, Type I Ha2 3 4
  • Keratin-32 3 4
  • HHa2 3 4
  • HKA2 3 4
  • HA2 3 6
  • K32 3 4
  • Keratin, Type I Cuticular Ha2 3
  • Type I Cuticular Hair Keratin 3
  • Hard Keratin, Type I, 2 3
  • Hard Keratin Type I 2
  • Keratin 32 2

External Ids for KRT32 Gene

Previous HGNC Symbols for KRT32 Gene

  • KRTHA2

Previous GeneCards Identifiers for KRT32 Gene

  • GC17M036870
  • GC17M039615
  • GC17M035379

Summaries for KRT32 Gene

Entrez Gene Summary for KRT32 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT32 Gene

KRT32 (Keratin 32, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT32 Gene

Genomics for KRT32 Gene

Regulatory Elements for KRT32 Gene

Genomic Location for KRT32 Gene

41,459,513 bp from pter
41,467,429 bp from pter
7,917 bases
Minus strand

Genomic View for KRT32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT32 Gene

Proteins for KRT32 Gene

  • Protein details for KRT32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KRT32 Gene

    448 amino acids
    Molecular mass:
    50343 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
    • Sequence=CAA57179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KRT32 Gene

Proteomics data for KRT32 Gene at MOPED

Post-translational modifications for KRT32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT32 Gene

Domains for KRT32 Gene

Gene Families for KRT32 Gene

Suggested Antigen Peptide Sequences for KRT32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT32: view

Function for KRT32 Gene

Gene Ontology (GO) - Molecular Function for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT32: view

Phenotypes for KRT32 Gene

GenomeRNAi human phenotypes for KRT32:
genes like me logo Genes that share phenotypes with KRT32: view

miRNA for KRT32 Gene

miRTarBase miRNAs that target KRT32

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT32

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT32 Gene

Localization for KRT32 Gene

Subcellular locations from

Jensen Localization Image for KRT32 Gene COMPARTMENTS Subcellular localization image for KRT32 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT32 Gene

Pathways for KRT32 Gene

SuperPathways for KRT32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 7556444
genes like me logo Genes that share ontologies with KRT32: view

No data available for Pathways by source for KRT32 Gene

Transcripts for KRT32 Gene

mRNA/cDNA for KRT32 Gene

(18) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT32 Gene

Keratin 32:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT32 Gene

No ASD Table

Relevant External Links for KRT32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT32 Gene

mRNA expression in normal human tissues for KRT32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT32 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (34.1), Skin - Sun Exposed (Lower leg) (8.0), and Esophagus - Mucosa (5.1).

Protein differential expression in normal tissues for KRT32 Gene

This gene is overexpressed in Cervix (21.9), Skin (15.9), Saliva (11.1), and Bone marrow mesenchymal stem cell (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT32 Gene

SOURCE GeneReport for Unigene cluster for KRT32 Gene Hs.41752

mRNA Expression by UniProt/SwissProt for KRT32 Gene

Tissue specificity: Restricted to the hair cuticle
genes like me logo Genes that share expressions with KRT32: view

Primer Products

In Situ Assay Products

No data available for Expression partners for KRT32 Gene

Orthologs for KRT32 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT32 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT32 35
  • 81.58 (n)
  • 75.25 (a)
KRT32 36
  • 75 (a)
(Canis familiaris)
Mammalia KRT32 35
  • 87.21 (n)
  • 83.52 (a)
KRT32 36
  • 83 (a)
(Mus musculus)
Mammalia Krt32 35
  • 82.07 (n)
  • 80.13 (a)
Krt32 16
Krt32 36
  • 79 (a)
(Pan troglodytes)
Mammalia KRT32 35
  • 99.4 (n)
  • 98.88 (a)
KRT32 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt32 35
  • 81.39 (n)
  • 80.1 (a)
(Monodelphis domestica)
Mammalia KRT32 36
  • 78 (a)
Species with no ortholog for KRT32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT32 Gene

Gene Tree for KRT32 (if available)
Gene Tree for KRT32 (if available)

Paralogs for KRT32 Gene

genes like me logo Genes that share paralogs with KRT32: view

Variants for KRT32 Gene

Sequence variations from dbSNP and Humsavar for KRT32 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs737487 -- 41,467,456(+) ATGTT(C/T)ACACC upstream-variant-2KB
rs867243 -- 41,468,074(-) TTATT(C/G)CATCT upstream-variant-2KB
rs897429 -- 41,467,634(-) GGGCC(C/T)GCCCT upstream-variant-2KB
rs928982 -- 41,468,364(-) TATTC(C/T)CAGTC upstream-variant-2KB
rs1111168 - 41,466,872(-) ATTGA(C/G)CAGCT frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT32 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
dgv962e1 CNV Complex 17122850
nsv510711 CNV Loss 20534489

Relevant External Links for KRT32 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT32 Gene

Disorders for KRT32 Gene

No disorders were found for KRT32 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRT32 Gene

Publications for KRT32 Gene

  1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 1996) 2 3 4 23
  2. Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PMID: 7556444) Rogers M.A. … Schweizer J. (Exp. Cell Res. 1995) 2 3 4
  3. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L. … Schweizer J. (J. Biol. Chem. 1999) 3 23
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for KRT32 Gene

Sources for KRT32 Gene

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