KRT31 Gene
protein-coding GIFtS: 50
GCID: GC17M039549
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|
keratin 31(Previous names: keratin, hair, acidic, 1 )
(Previous symbol: KRTHA1)
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Aliases
for KRT31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 311 2 | | Hard Keratin, Type I, 12 | | KRTHA11 2 3 5 | | Keratin, Hair, Acidic,12 | | Ha-11 2 | | Keratin, Type I Cuticular Ha12 | | Hair Keratin, Type I Ha12 3 | | Keratin-313 | | K312 3 | | HHA13 | | HA12 5 | | HKA13 | | Keratin, Hair, Acidic, 11 | | Keratin-313 | | HHa11 | | |
Export aliases for KRT31 gene to outside databasesPrevious GC identifers: GC17M036804 GC17M035313 |
Summaries
for KRT31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT31:
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidicprotein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered ina region of chromosome 17q12-q21 and have the same direction of transcription. (provided by RefSeq, Jul 2008)
Gene Wiki entry for KRT31
|
Genomic Views
for KRT31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT31 gene promoter:
Tal-1 Bach2 Nkx2-5 Meis-1b E47 FAC1 c-Myb Meis-1a MRF-2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT31
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT31 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRT31 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039549: view genomic region
(about GC identifiers)
Start:
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39,549,976 bp from pter |
End:
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39,553,844 bp from pter |
Size:
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3,869 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17+,PATCHES 39,495,068-39,498,936 |
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Proteins
for KRT31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K1H1_HUMAN, Q15323 (See
protein sequence)Recommended Name: Keratin, type I cuticular Ha1 Size: 416 amino acids; 47237 Da
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: Q9UE12Explore the universe of human proteins at neXtProt for KRT31: NX_Q15323
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15323
KRT31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002268.2
ENSEMBL proteins: ENSP00000251645
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT31 for ontologies About GeneDecksing
KRT31 Antibody Products:
Assay Products for KRT31: |
Protein
Domains /
Families
for KRT31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT31 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15323ProtoNet protein and cluster: Q15323 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1H1_HUMAN, Q15323Similarity: Belongs to the intermediate filament family |
Function
for KRT31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KRT31 (NM_002277) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT31 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005200 | structural constituent of cytoskeleton |
TAS | 9405442 |
KRT31 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT31:
|
Pathways & Interactions
for KRT31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT31
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/32 Interacting proteins for KRT31 (Q153232, 3 ENSP000002516454) via UniProtKB, MINT, STRING, and/or I2D (see all 32)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
KRT31 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT31
Search CenterWatch for drugs/clinical trials and news about KRT31 / K1H1
|
Transcripts
for KRT31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT31 gene: NM_002277.2 Unigene Cluster for KRT31: Keratin 31 Hs.41696 [show with all ESTs]Unigene Representative Sequence: NM_0022771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000251645(uc002hwn.3 uc010cxn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT31 (NM_002277) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT31 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT31 |
Additional cDNA sequence: AK313419.1 BC114468.1 X86570.1 4 DOTS entries: DT.209056 DT.100737185 DT.91754618 DT.120922651 24/76 AceView cDNA sequences (see all 76): BF197281 AW069789 BM915709 AJ633621 BC009971 BM808576 NM_021013 AA340065 AW169840 NM_004138 BC033252 NM_002279 NM_002277 AF086202 AA326093 BM423546 BM809363 BM915177 AW206500 BM915230 CB150240 BM556055 AI131081 X82634
GeneLoc Exon Structure
|
Expression
for KRT31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGAGTTG
About this image
See KRT31 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT31
SOURCE GeneReport for Unigene cluster: Hs.41696
UniProtKB/Swiss-Prot: K1H1_HUMAN, Q15323Tissue specificity: Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex ofgrowing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner rootsheath and medulla
SABiosciences Custom PCR Arrays for KRT31
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT31
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT31 |
Orthologs
for KRT31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT31 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for KRT31 (if available)
TreeFam Gene Tree for KRT31 (if available) |
Paralogs
for KRT31 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT31 gene
- KRT342 KRT2222 ENSG000002640582 KRT352 KRT392 KRT402 BFSP22 KRT372
- KRT322 KRT382 KRT362 KRT33B2 KRT33A2
18/37 SIMAP similar genes for KRT31 using alignment to 1 protein entry: K1H1_HUMAN(see all similar genes):type I hair keratin KRT33A KRT33B KRT34 KRT36 KRT19
KRT15 KRT32 KRT35 KRT37 KRT16 KRT13
KRT14 KRT20 KRT38 KRTHA7 KRT10 KRT12
KRT31 for paralogs About GeneDecksing
|
Genomic Variants
for KRT31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT31 (39549976 - 39553844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KRT31
3 CNVs: 0205 35457 4036
Human Gene Mutation Database (HGMD): KRT31
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT31 |
|
Disorders
/ Diseases
for KRT31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT31 for disorders About GeneDecksing
OMIM gene information: 601077
OMIM disorders: --
6  diseases for KRT31: About MalaCardsskin pilomatrix carcinoma nodular basal cell carcinoma basal cell carcinoma ataxia
esophagitis carcinoma
2 diseases from the University of Copenhagen DISEASES database for KRT31:Skin pilomatrix carcinoma Nodular basal cell carcinoma Export disorders for KRT31 gene to outside databases
|
Publications
for KRT31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT31 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with KRT31) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A cDNA encoding the human type I hair keratin hHal. (PubMed id 7578244)1, 2, 3 Fink P.... Schweizer J. (1995)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PubMed id 9756910)1, 2 Rogers M.A.... Schweizer J. (1998)
- Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PubMed id 9457912)1, 2 Bowden P.E.... Hodgins M.B. (1998)
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PubMed id 10391933)1, 9 Langbein L....Schweizer J. (1999)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- On the regulation of hair keratin expression: lessons from studies in pilomatricomas. (PubMed id 15140206)1 Cribier B....Schweizer J. (2004)
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External Searches for KRT31 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT31 gene:
Search GeneIP for patents involving KRT31
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KRT31 | | OriGene shRNA RFP for KRT31 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT31 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT31 | | | OriGene Protein Over-expression Lysate for KRT31 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT31 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT31 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT31 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT31 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT31 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT31 |
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 | | | KRT31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for KRT31 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT31 |
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