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Aliases for KRT3 Gene

Aliases for KRT3 Gene

  • Keratin 3, Type II 2 3
  • Type-II Keratin Kb3 3 4
  • 65 KDa Cytokeratin 3 4
  • Cytokeratin 3 2 3
  • Cytokeratin-3 3 4
  • CK-3 3 4
  • K3 3 4
  • Keratin, Type II Cytoskeletal 3 3
  • Type II Cytoskeletal 3 2
  • Keratin 3 2
  • Keratin-3 4
  • Keratin 2
  • CK3 3

External Ids for KRT3 Gene

Previous GeneCards Identifiers for KRT3 Gene

  • GC12M053297
  • GC12P053675
  • GC12M052626
  • GC12M051469
  • GC12M053183
  • GC12M050227

Summaries for KRT3 Gene

Entrez Gene Summary for KRT3 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT3 Gene

KRT3 (Keratin 3, Type II) is a Protein Coding gene. Diseases associated with KRT3 include meesmann corneal dystrophy and burns. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT3 Gene

Genomics for KRT3 Gene

Regulatory Elements for KRT3 Gene

Genomic Location for KRT3 Gene

52,789,685 bp from pter
52,796,117 bp from pter
6,433 bases
Minus strand

Genomic View for KRT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT3 Gene

Proteins for KRT3 Gene

  • Protein details for KRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 3
    Protein Accession:
    Secondary Accessions:
    • A6NIS2
    • Q701L8

    Protein attributes for KRT3 Gene

    628 amino acids
    Molecular mass:
    64417 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    • Sequence=CAF31522.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KRT3 Gene

Proteomics data for KRT3 Gene at MOPED

Post-translational modifications for KRT3 Gene

  • Ubiquitination at Lys208, Lys215, and Lys289
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT3 Gene

Domains for KRT3 Gene

Gene Families for KRT3 Gene

  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12035
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT3: view

Function for KRT3 Gene

Molecular function for KRT3 Gene

GENATLAS Biochemistry:
keratin 3,type II (64kDa),expressed during corneal differentiation

Gene Ontology (GO) - Molecular Function for KRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IMP 9171831
genes like me logo Genes that share ontologies with KRT3: view

Phenotypes for KRT3 Gene

genes like me logo Genes that share phenotypes with KRT3: view

miRNA for KRT3 Gene

miRTarBase miRNAs that target KRT3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT3 Gene

Localization for KRT3 Gene

Subcellular locations from

Jensen Localization Image for KRT3 Gene COMPARTMENTS Subcellular localization image for KRT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for KRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament NAS 9171831
GO:0045095 keratin filament TAS 9171831
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT3 Gene

Pathways for KRT3 Gene

SuperPathways for KRT3 Gene

No Data Available

Interacting Proteins for KRT3 Gene

Gene Ontology (GO) - Biological Process for KRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation ISS --
GO:0045104 intermediate filament cytoskeleton organization IMP 9171831
genes like me logo Genes that share ontologies with KRT3: view

No data available for Pathways by source for KRT3 Gene

Compounds for KRT3 Gene

(4) Novoseek inferred chemical compound relationships for KRT3 Gene

Compound -log(P) Hits PubMed IDs
mitomycin c 39.2 1
bromodeoxyuridine 8.03 1
proline 5.48 1
arginine 0 1
genes like me logo Genes that share compounds with KRT3: view

Transcripts for KRT3 Gene

mRNA/cDNA for KRT3 Gene

(251) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT3 Gene

Keratin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP2: - - - - - - -

Relevant External Links for KRT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT3 Gene

mRNA expression in normal human tissues for KRT3 Gene

mRNA differential expression in normal tissues according to GTEx for KRT3 Gene

This gene is overexpressed in Esophagus - Mucosa (24.6), Minor Salivary Gland (6.0), Vagina (5.2), and Cervix - Ectocervix (4.4).

Protein differential expression in normal tissues for KRT3 Gene

This gene is overexpressed in Saliva (39.0) and Cervix (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT3 Gene

SOURCE GeneReport for Unigene cluster for KRT3 Gene Hs.680652

mRNA Expression by UniProt/SwissProt for KRT3 Gene

Tissue specificity: Cornea specific
genes like me logo Genes that share expressions with KRT3: view

In Situ Assay Products

No data available for Expression partners for KRT3 Gene

Orthologs for KRT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT3 36
  • 84 (a)
(Canis familiaris)
Mammalia KRT3 36
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
(Mus musculus)
Mammalia 4732456N10Rik 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
(Pan troglodytes)
Mammalia KRT3 36
  • 98 (a)
(Gallus gallus)
Aves -- 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
Species with no ortholog for KRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT3 Gene

Gene Tree for KRT3 (if available)
Gene Tree for KRT3 (if available)

Paralogs for KRT3 Gene Pseudogenes for KRT3 Gene

genes like me logo Genes that share paralogs with KRT3: view

Variants for KRT3 Gene

Sequence variations from dbSNP and Humsavar for KRT3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1873648 -- 52,796,199(-) AATAT(C/T)TGGGA upstream-variant-2KB
rs3215031 -- 52,794,425(-) GGGGG(-/G)CCCAG intron-variant
rs3887954 - 52,792,304(+) TGCAC(C/G)AACTT reference, missense
rs4432093 -- 52,792,338(+) AGGGA(A/G)CGATT reference, synonymous-codon
rs4919750 -- 52,793,366(-) AGGGA(A/G)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT3 Gene

Variant ID Type Subtype PubMed ID
nsv899093 CNV Gain 21882294
nsv899094 CNV Gain 21882294
nsv899095 CNV Loss 21882294
nsv832416 CNV Loss 17160897

Relevant External Links for KRT3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT3 Gene

Disorders for KRT3 Gene

(1) OMIM Diseases for KRT3 Gene (148043)


  • Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. {ECO:0000269 PubMed:16227835, ECO:0000269 PubMed:9171831}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(5) Novoseek inferred disease relationships for KRT3 Gene

Disease -log(P) Hits PubMed IDs
corneal dystrophy 87.1 7
corneal diseases 71.1 2
keratoconus 52.6 1
amyloid deposition 33.9 1
carcinoma squamous cell 0 1

Relevant External Links for KRT3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with KRT3: view

No data available for Genatlas for KRT3 Gene

Publications for KRT3 Gene

  1. Assignment of the human cytokeratin 3 gene (KRT3) to 12q12-->q13 by FISH. (PMID: 7510223) Raimondi E. … Romano V. (Cytogenet. Cell Genet. 1994) 2 3 23
  2. Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy. (PMID: 16227835) Chen Y.T. … Chao S.C. (Cornea 2005) 3 4 23
  3. Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. (PMID: 18806880) Szaflik J.P. … Szaflik J. (Mol. Vis. 2008) 3 23
  4. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. (PMID: 9171831) Irvine A.D. … McLean W.H.I. (Nat. Genet. 1997) 3 4
  5. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4

Products for KRT3 Gene

Sources for KRT3 Gene

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