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KRT3 Gene

protein-coding   GIFtS: 54
GCID: GC12M053183

Keratin 3

  See KRT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 31 2     Type II Cytoskeletal 31
Cytokeratin 31 2     CK32
Type-II Keratin Kb32 3     cytokeratin-32
65 KDa Cytokeratin2 3     Keratin, Type II Cytoskeletal 32
CK-32 3     Cytokeratin-33
K32 3     Keratin-33
keratin1     

External Ids:    HGNC: 64401   Entrez Gene: 38502   Ensembl: ENSG000001864427   OMIM: 1480435   UniProtKB: P120353   

Export aliases for KRT3 gene to outside databases

Previous GC identifers: GC12M053297 GC12P053675 GC12M052626 GC12M051469 GC12M050227


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT3 Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal
epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal
Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. (provided by RefSeq, Jul
2008)

GeneCards Summary for KRT3 Gene:
KRT3 (keratin 3) is a protein-coding gene. Diseases associated with KRT3 include burns, and hymenolepiasis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

Gene Wiki entry for KRT3 (Keratin 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KRT3 gene promoter:
         RFX1   AML1a   p53   p300   AP-4   Tal-1beta   YY1   E47   PPAR-alpha   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT3 promoter sequence
   Search Chromatin IP Primers for KRT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053183:  view genomic region     (about GC identifiers)

Start:
53,183,469 bp from pter      End:
53,189,901 bp from pter
Size:
6,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 3  
Size: 628 amino acids; 64417 Da
Subunit: Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Sequence caution: Sequence=CAF31522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIS2 Q701L8

Explore the universe of human proteins at neXtProt for KRT3: NX_P12035

Explore proteomics data for KRT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208, Lys215, Lys289
  • Modification sites at PhosphoSitePlus

  • See KRT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_476429.2  
    ENSEMBL proteins: 
     ENSP00000413479   ENSP00000312206  

    KRT3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KRT3

     
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    KRT3 Antibody Products:

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    Abcam antibodies for KRT3 (Q99456, P19013, P12035)
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    LSBio Antibodies in human, mouse, rat for KRT3

    KRT3 Assay Products:

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    Cloud-Clone Corp. ELISAs for KRT3
    Cloud-Clone Corp. CLIAs for KRT3
    Search eBioscience for ELISAs for KRT3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P12035

    ProtoNet protein and cluster: P12035

    4 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for KRT3:
    keratin 3,type II (64kDa),expressed during corneal differentiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IMP9171831
         
    Find genes that share ontologies with KRT3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT3:
     Decreased G3BP1 protein expres 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT3:
    hsa-mir-186-5p (MIRT044922)

    Block miRNA regulation of human, mouse, rat KRT3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT3:
    hsa-miR-1273 hsa-miR-499-3p hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KRT3
    Predesigned siRNA for gene silencing in human, mouse, rat KRT3

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament NAS9171831
    GO:0045095keratin filament TAS9171831

    Find genes that share ontologies with KRT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT3
    Interactions:

        Search GeneGlobe Interaction Network for KRT3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for KRT3 (P120353 ENSP000004134794) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX1BQ9BQ833, ENSP000003289404I2D: score=1 STRING: ENSP00000328940
    SLX1AQ9BQ833I2D: score=1 
    AMBRA1Q9C0C73I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ----
    GO:0030855epithelial cell differentiation ISS--
    GO:0045104intermediate filament cytoskeleton organization IMP9171831

    Find genes that share ontologies with KRT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT3 (K2C3)

    4 Novoseek inferred chemical compound relationships for KRT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 39.2 1 1718924 (1)
    bromodeoxyuridine 8.03 2 16123387 (1)
    proline 5.48 1 16227835 (1)
    arginine 0 1 16227835 (1)



    Find genes that share compounds with KRT3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT3 gene: 
    NM_057088.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417996(uc001say.3) ENST00000309505
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT3:
    hsa-miR-1273 hsa-miR-499-3p hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT3
    Predesigned siRNA for gene silencing in human, mouse, rat KRT3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for KRT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KRT3
      QuantiTect SYBR Green Assays in human, mouse, rat KRT3
      QuantiFast Probe-based Assays in human, mouse, rat KRT3

    Selected AceView cDNA sequences (see all 251):

    AW265613 BM697307 AK130156 C00570 NM_175834 AA629199 BE742142 BQ027522 
    AW082111 BG741384 AJ564105 AU077018 BM715509 BC039148 BP371899 BF830977 
    BE735977 AK096419 BU727843 BM728640 AW087981 BC063648 BG697577 BG743065 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                                                        
    SP2:                          -     -     -     -     -     -     -         
    SP3:                                                                        


    ECgene alternative splicing isoforms for KRT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCCAAGA
    KRT3 Expression
    About this image


    KRT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 16 entries
             Fetal Corneal Superficial Epithelial Cells Corneal Epithelium
             Limbal epithelial stem cells
     
     Epithelial Cells
             Fetal Corneal Superficial Epithelial Cells Corneal Epithelium
     
     Epidermis (Integumentary System)
             Purified keratinocyte-like cells
    KRT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT3 Protein Expression

    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
    Tissue specificity: Cornea specific

        Custom PCR Arrays for KRT3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    62(a)
    1 → many
    LGE22C19W28_E50C23(558727-563179)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    2(95689544-95704356)
            Species with no ortholog for KRT3

    ENSEMBL Gene Tree for KRT3 (if available)
    TreeFam Gene Tree for KRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT3 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT3 using alignment to 2 protein entries:     K2C3_HUMAN (see all proteins) (see all similar genes):
    KRT7    KRT76    KRT5    KRT121P    KRT4    KRT1B
    KRT72    KRTHB6    KRT78    KRT71    KRT8    KRT1
    KRT79    KRT6A    KRT2    KRT6B    KRT6C    KRT85

    Find genes that share paralogs with KRT3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KRT3
    PGOHUM00000239462


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT3 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs578720711,2,,4
    CCorneal dystrophy, Meesmann (MECD)4 pathogenic153019426(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs604100631,2,,4
    CCorneal dystrophy, Meesmann (MECD)4 untested153019443(-) CTACCC/G/TCAAGC 2 P R mis10--------
    rs747775601,2
    F--50231553(-) GACCAC/G/TCCTGG 1 -- int12NA 4
    rs177388621,2
    C,F,H--53017433(+) GGCTTC/TCAGCA 1 -- ds500114Minor allele frequency- T:0.03NA NS EA 1418
    rs1814503661,2
    --53017566(+) AGAAGA/GCAGGG 1 -- ds50010--------
    rs1862834611,2
    --53017569(+) AGACAA/GGGAGG 1 -- ds50010--------
    rs1429989321,2
    C--53017581(+) GACAGA/GTGTCT 1 -- ds50010--------
    rs1901740851,2
    --53017612(+) CTAAGA/GACGGT 1 -- ds50010--------
    rs1831114361,2
    C--53017621(+) GTAAGA/GGTACA 1 -- ds50010--------
    rs1125870831,2
    C,F--53017674(+) CGGTGC/TTCACA 1 -- ds50012Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for KRT3 (53183469 - 53189901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KRT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832416CNV Loss17160897
    nsv899095CNV Loss21882294
    nsv899093CNV Gain21882294
    nsv899094CNV Gain21882294

    Human Gene Mutation Database (HGMD): KRT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT3
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148043   
    OMIM disorders: 122100  
    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
  • Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by
    fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of
    the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens
    intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal
    astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened
    epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for KRT3:    
    About MalaCards
    burns    hymenolepiasis    limbal stem cell deficiency    meesmann corneal dystrophy
    keratoconus    corneal disease    breast disease    pterygium
    wegener's granulomatosis

    4 diseases from the University of Copenhagen DISEASES database for KRT3:
    Corneal dystrophy     Stevens-Johnson syndrome     Hymenolepiasis     Cicatricial pemphigoid

    Find genes that share disorders with KRT3           About GenesLikeMe

    5 Novoseek inferred disease relationships for KRT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    corneal dystrophy 87.1 9 16227835 (2), 10612503 (1), 10621529 (1), 19236704 (1) (see all 6)
    corneal diseases 71.1 2 12700042 (1), 16083875 (1)
    keratoconus 52.6 1 16083875 (1)
    amyloid deposition 33.9 1 12700042 (1)
    carcinoma squamous cell 0 1 7507359 (1)

    Genetic Association Database (GAD): KRT3

    Export disorders for KRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT3 gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with KRT3)
        Utopia: connect your pdf to the dynamic
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    1. Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy. (PubMed id 16227835)1, 2, 9 Chen Y.T.... Chao S.C. (Cornea 2005)
    2. Assignment of the human cytokeratin 3 gene (KRT3) to 12q12--&gt;q13 by FISH. (PubMed id 7510223)1, 3, 9 Raimondi E....Romano V. (Cytogenet. Cell Genet. 1994)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (J. Invest. Dermatol. 2005)
    5. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. (PubMed id 9171831)1, 2 Irvine A.D.... McLean W.H.I. (Nat. Genet. 1997)
    6. Evolution of keratin genes: different protein domains evolve by different pathways. (PubMed id 2439698)1, 2 Klinge E.M.... Blumenberg M. (J. Mol. Evol. 1987)
    7. Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. (PubMed id 18806880)1, 9 Szaflik J.P....Szaflik J. (Mol. Vis. 2008)
    8. Autosomal-dominant Meesmann epithelial corneal dystrophy without an exon mutation in the keratin-3 or keratin-12 gene in a Chinese family. (PubMed id 23569037)1 Cao W....Wu W. (J. Int. Med. Res. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3850 HGNC: 6440 AceView: KRT4andHUMCYT2AandKRT3andK5BandKRT6L Ensembl:ENSG00000186442 euGenes: HUgn3850
    ECgene: KRT3 H-InvDB: KRT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT3 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    Wikipedia http://en.wikipedia.org/wiki/Keratin_3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT3 gene:
    Search GeneIP for patents involving KRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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