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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT3 Gene

protein-coding   GIFtS: 57
GCID: GC12M053183

Keratin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 31 2     Type II Cytoskeletal 31
Cytokeratin 31 2     CK32
Type-II Keratin Kb32 3     cytokeratin-32
65 KDa Cytokeratin2 3     Keratin, Type II Cytoskeletal 32
CK-32 3     Cytokeratin-33
K32 3     Keratin-33
keratin1     

External Ids:    HGNC: 64401   Entrez Gene: 38502   Ensembl: ENSG000001864427   OMIM: 1480435   UniProtKB: P120353   

Export aliases for KRT3 gene to outside databases

Previous GC identifers: GC12M053297 GC12P053675 GC12M052626 GC12M051469 GC12M050227


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT3 Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal
epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal
Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. (provided by RefSeq, Jul
2008)

GeneCards Summary for KRT3 Gene: 
KRT3 (keratin 3) is a protein-coding gene. Diseases associated with KRT3 include limbal stem cell deficiency, and iridocorneal endothelial syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

Gene Wiki entry for KRT3 (Keratin 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT3 gene promoter:
         RFX1   AML1a   p53   p300   AP-4   Tal-1beta   YY1   E47   PPAR-alpha   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053183:  view genomic region     (about GC identifiers)

Start:
53,183,469 bp from pter      End:
53,189,901 bp from pter
Size:
6,433 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 3  
Size: 628 amino acids; 64417 Da
Subunit: Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Sequence caution: Sequence=CAF31522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIS2 Q701L8

Explore the universe of human proteins at neXtProt for KRT3: NX_P12035

Explore proteomics data for KRT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12035

  • KRT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT3 Protein Expression
    REFSEQ proteins: NP_476429.2  
    ENSEMBL proteins: 
     ENSP00000413479   ENSP00000312206  

    Human Recombinant Protein Products for KRT3: 
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    Novus Biologicals KRT3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament NAS9171831
    GO:0045095keratin filament TAS9171831

    KRT3 for ontologies           About GeneDecksing



    KRT3 Antibody Products: 
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    Assay Products for KRT3: 
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    Cloud-Clone Corp. ELISAs for KRT3 
    Cloud-Clone Corp. CLIAs for KRT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P12035

    ProtoNet protein and cluster: P12035

    4 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
    Similarity: Belongs to the intermediate filament family


    KRT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for KRT3:
    keratin 3,type II (64kDa),expressed during corneal differentiation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS--
         
    KRT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT3:
     Decreased G3BP1 protein expres 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT3:
    hsa-miR-1273 hsa-miR-499-3p hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/20 Interacting proteins for KRT3 (P120353 ENSP000004134794) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX1BQ9BQ833, ENSP000003289404I2D: score=1 STRING: ENSP00000328940
    SLX1AQ9BQ833I2D: score=1 
    AMBRA1Q9C0C73I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS--
    GO:0030855epithelial cell differentiation ISS--
    GO:0045104intermediate filament cytoskeleton organization IMP9171831

    KRT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT3 (K2C3)

    4 Novoseek inferred chemical compound relationships for KRT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 39.2 1 1718924 (1)
    bromodeoxyuridine 8.03 2 16123387 (1)
    proline 5.48 1 16227835 (1)
    arginine 0 1 16227835 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT3 / K2C3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT3 gene: 
    NM_057088.2  

    Unigene Cluster for KRT3:

    Keratin 3
    Hs.680652  [show with all ESTs]
    Unigene Representative Sequence: NM_057088
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417996(uc001say.3) ENST00000309505
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT3:
    hsa-miR-1273 hsa-miR-499-3p hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT3
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT3
    Sirion Biotech Customized lentivirus for stable overexpression of KRT3 
                         Customized lentivirus expression plasmids for stable overexpression of KRT3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT3

    Additional mRNA sequence: 

    AJ628418.1 AK314987.1 

    5 DOTS entries:

    DT.40246526  DT.121117704  DT.121118980  DT.91647885  DT.97773116 

    24/251 AceView cDNA sequences (see all 251):

    BE735977 BF830977 AW265613 AK130156 AU077018 BG741384 BC039148 C00570 
    AJ564105 BE742142 BP371899 NM_175834 AA629199 BQ027522 AW082111 BM715509 
    BM697307 BG674413 BG743160 BG696559 BM667942 NM_015848 BG743357 BG739905 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                                                        
    SP2:                          -     -     -     -     -     -     -         
    SP3:                                                                        


    ECgene alternative splicing isoforms for KRT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT3 expression in normal human tissues (normalized intensities)      KRT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCCAAGA
    KRT3 Expression
    About this image


    KRT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Limbal stem cells

    See KRT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT3

    SOURCE GeneReport for Unigene cluster: Hs.680652

    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
    Tissue specificity: Cornea specific

        SABiosciences Custom PCR Arrays for KRT3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT3 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1006834011 uncharacterized LOC100683401 85.16(n)
    86.88(a)
      100683401  XM_003433501.1  XP_003433549.1 
    chicken
    (Gallus gallus)
    Aves KRT31 keratin 3 68.49(n)
    68.27(a)
      769040  XM_001232220.2  XP_001232221.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    53(a)
    49(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(95440022-95458665)
    2(95490801-95512216)
    zebrafish
    (Danio rerio)
    Actinopterygii krt51 keratin 5 63.28(n)
    61.96(a)
      797351  NM_131156.1  NP_571231.1 


    ENSEMBL Gene Tree for KRT3 (if available)
    TreeFam Gene Tree for KRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT3 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    18/47 SIMAP similar genes for KRT3 using alignment to 2 protein entries:     K2C3_HUMAN (see all proteins) (see all similar genes):
    KRT7    KRT76    KRT5    KRT121P    KRT4    KRT1B
    KRT72    KRTHB6    KRT78    KRT71    KRT8    KRT1
    KRT79    KRT6A    KRT2    KRT6B    KRT6C    KRT85

    KRT3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT3
    PGOHUM00000239462


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/307 SNPs in KRT3 are shown (see all 307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs578720711,2,4
    CCorneal dystrophy, Meesmann (MECD)4 pathogenic153019426(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs604100631,2,4
    CCorneal dystrophy, Meesmann (MECD)4 untested153019443(-) CTACCC/G/TCAAGC 2 P R mis10--------
    rs747775601,2
    F--50231553(-) GACCAC/G/TCCTGG 1 -- int12NA 4
    rs177388621,2
    C,F,H--53017433(+) GGCTTC/TCAGCA 1 -- ds500114Minor allele frequency- T:0.03NA NS EA 1418
    rs1814503661,2
    --53017566(+) AGAAGA/GCAGGG 1 -- ds50010--------
    rs1862834611,2
    --53017569(+) AGACAA/GGGAGG 1 -- ds50010--------
    rs1429989321,2
    C--53017581(+) GACAGA/GTGTCT 1 -- ds50010--------
    rs1901740851,2
    --53017612(+) CTAAGA/GACGGT 1 -- ds50010--------
    rs1831114361,2
    C--53017621(+) GTAAGA/GGTACA 1 -- ds50010--------
    rs1125870831,2
    C,F--53017674(+) CGGTGC/TTCACA 1 -- ds50012Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for KRT3 (53183469 - 53189901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KRT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832416CNV Loss17160897
    nsv899095CNV Loss21882294
    nsv899093CNV Gain21882294
    nsv899094CNV Gain21882294


    Human Gene Mutation Database (HGMD): KRT3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT3
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148043   
    OMIM disorders: 122100  
    UniProtKB/Swiss-Prot: K2C3_HUMAN, P12035
  • Corneal dystrophy, Meesmann (MECD) [MIM:122100]: An autosomal dominant corneal disease characterized by
    fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of
    the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens
    intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal
    astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened
    epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/26 diseases for KRT3 (see all 26):    About MalaCards
    limbal stem cell deficiency    iridocorneal endothelial syndrome    infarct of liver    hymenolepiasis
    meesmann corneal dystrophy    keratoconus    corneal disease    t cell deficiency
    astigmatism    autosomal dominant disease    pterygium    stevens-johnson syndrome
    corneal dystrophy    cicatricial pemphigoid    wegener's granulomatosis    breast disease
    keratitis    urethritis    oral squamous cell carcinoma    endotheliitis

    4 diseases from the University of Copenhagen DISEASES database for KRT3:
    Corneal dystrophy     Stevens-Johnson syndrome     Hymenolepiasis     Cicatricial pemphigoid

    KRT3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for KRT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    corneal dystrophy 87.1 9 16227835 (2), 10612503 (1), 10621529 (1), 19236704 (1) (see all 6)
    corneal diseases 71.1 2 12700042 (1), 16083875 (1)
    keratoconus 52.6 1 16083875 (1)
    amyloid deposition 33.9 1 12700042 (1)
    carcinoma squamous cell 0 1 7507359 (1)

    Genetic Association Database (GAD): KRT3

    Export disorders for KRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT3 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with KRT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy. (PubMed id 16227835)1, 2, 9 Chen Y.T.... Chao S.C. (2005)
    2. Assignment of the human cytokeratin 3 gene (KRT3) to 12q12-->q13 by FISH. (PubMed id 7510223)1, 3, 9 Raimondi E....Romano V. (1994)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
    5. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. (PubMed id 9171831)1, 2 Irvine A.D.... McLean W.H.I. (1997)
    6. Evolution of keratin genes: different protein domains evolve by different pathways. (PubMed id 2439698)1, 2 Klinge E.M.... Blumenberg M. (1987)
    7. Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. (PubMed id 18806880)1, 9 Szaflik J.P....Szaflik J. (2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3850 HGNC: 6440 AceView: KRT4andHUMCYT2AandKRT3andK5BandKRT6L Ensembl:ENSG00000186442 euGenes: HUgn3850
    ECgene: KRT3 H-InvDB: KRT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT3 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    Wikipedia http://en.wikipedia.org/wiki/Keratin_3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT3 gene:
    Search GeneIP for patents involving KRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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