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Aliases for KRT27 Gene

Aliases for KRT27 Gene

  • Keratin 27, Type I 2 3
  • Type I Inner Root Sheath-Specific Keratin-K25irs3 3 4
  • Cytokeratin-27 3 4
  • Keratin 25C 2 3
  • Keratin-25C 3 4
  • Keratin-27 3 4
  • KRT25C 3 4
  • CK-27 3 4
  • K25C 3 4
  • K27 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs3 3
  • Keratin, Type I Cytoskeletal 27 3
  • Keratin 27 2

External Ids for KRT27 Gene

Previous Symbols for KRT27 Gene

  • KRT25C

Summaries for KRT27 Gene

Entrez Gene Summary for KRT27 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT27 Gene

KRT27 (Keratin 27, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot for KRT27 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT27 Gene

Genomics for KRT27 Gene

Genomic Location for KRT27 Gene

Start:
40,776,808 bp from pter
End:
40,782,534 bp from pter
Size:
5,727 bases
Orientation:
Minus strand

Genomic View for KRT27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT27 Gene

Regulatory Elements for KRT27 Gene

Proteins for KRT27 Gene

  • Protein details for KRT27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Y8-K1C27_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 27
    Protein Accession:
    Q7Z3Y8
    Secondary Accessions:

    Protein attributes for KRT27 Gene

    Size:
    459 amino acids
    Molecular mass:
    49822 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT27 Gene

Proteomics data for KRT27 Gene at MOPED

Post-translational modifications for KRT27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT27 Gene

Domains for KRT27 Gene

Gene Families for KRT27 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT27 Gene

UniProtKB/Swiss-Prot:

K1C27_HUMAN
Family:
  • Belongs to the intermediate filament family.:
    • Q7Z3Y8
genes like me logo Genes that share domains with KRT27: view

Function for KRT27 Gene

Molecular function for KRT27 Gene

UniProtKB/Swiss-Prot Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

Gene Ontology (GO) - Molecular Function for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT27: view

Phenotypes for KRT27 Gene

MGI mutant phenotypes for KRT27:
inferred from 1 alleles
GenomeRNAi human phenotypes for KRT27:
genes like me logo Genes that share phenotypes with KRT27: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT27 Gene

Localization for KRT27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT27 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT27 Gene COMPARTMENTS Subcellular localization image for KRT27 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT27: view

Pathways for KRT27 Gene

SuperPathways for KRT27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031069 hair follicle morphogenesis IEA --
genes like me logo Genes that share ontologies with KRT27: view

No data available for Pathways by source for KRT27 Gene

Transcripts for KRT27 Gene

mRNA/cDNA for KRT27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT27 Gene

Keratin 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT27 Gene

No ASD Table

Relevant External Links for KRT27 Gene

GeneLoc Exon Structure for
KRT27
ECgene alternative splicing isoforms for
KRT27

Expression for KRT27 Gene

mRNA expression in normal human tissues for KRT27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (41.7) and Skin - Sun Exposed (Lower leg) (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT27 Gene

SOURCE GeneReport for Unigene cluster for KRT27 Gene Hs.59363

mRNA Expression by UniProt/SwissProt for KRT27 Gene

Q7Z3Y8-K1C27_HUMAN
Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).
genes like me logo Genes that share expressions with KRT27: view

Orthologs for KRT27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT27 36
  • 99.56 (n)
  • 99.56 (a)
KRT27 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT27 36
  • 87.87 (n)
  • 91.72 (a)
KRT27 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT27 36
  • 90.34 (n)
  • 94.38 (a)
KRT27 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt27 36
  • 83.41 (n)
  • 88.62 (a)
Krt27 16
Krt27 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 58 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 87 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krt27 36
  • 83.89 (n)
  • 89.76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt16 36
  • 61.98 (n)
  • 57.03 (a)
Species with no ortholog for KRT27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT27 Gene

ENSEMBL:
Gene Tree for KRT27 (if available)
TreeFam:
Gene Tree for KRT27 (if available)

Paralogs for KRT27 Gene

genes like me logo Genes that share paralogs with KRT27: view

Variants for KRT27 Gene

Sequence variations from dbSNP and Humsavar for KRT27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs929496 -- 40,779,936(+) tcgct(C/G)tgatg intron-variant
rs981684 - 40,779,560(+) TCTCG(A/G)TAAGC missense, reference
rs981685 -- 40,779,578(+) GGGCT(A/G)AGGTG reference, missense
rs2252403 -- 40,778,033(+) AGCCT(A/G)TGCTT intron-variant
rs2286648 -- 40,777,866(+) CACTT(C/G)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT27 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294
dgv3166n71 CNV Loss 21882294

Relevant External Links for KRT27 Gene

HapMap Linkage Disequilibrium report
KRT27

Disorders for KRT27 Gene

No disorders were found for KRT27 Gene.

No data available for UniProtKB/Swiss-Prot for KRT27 Gene

Publications for KRT27 Gene

  1. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PMID: 16874310) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2006) 4

Products for KRT27 Gene

Sources for KRT27 Gene

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