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Aliases for KRT27 Gene

Aliases for KRT27 Gene

  • Keratin 27 2 3
  • Keratin 27, Type I 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs3 3 4
  • Cytokeratin-27 3 4
  • Keratin 25C 2 3
  • Keratin-25C 3 4
  • Keratin-27 3 4
  • KRT25C 3 4
  • CK-27 3 4
  • K25C 3 4
  • K27 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs3 3
  • K25IRS3 3

External Ids for KRT27 Gene

Previous HGNC Symbols for KRT27 Gene

  • KRT25C

Previous GeneCards Identifiers for KRT27 Gene

  • GC17M036187
  • GC17M038933
  • GC17M034728

Summaries for KRT27 Gene

Entrez Gene Summary for KRT27 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT27 Gene

KRT27 (Keratin 27) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

UniProtKB/Swiss-Prot for KRT27 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT27 Gene

Genomics for KRT27 Gene

Regulatory Elements for KRT27 Gene

Enhancers for KRT27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT27 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT27 Gene

40,776,808 bp from pter
40,782,534 bp from pter
5,727 bases
Minus strand

Genomic View for KRT27 Gene

Genes around KRT27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT27 Gene

Proteins for KRT27 Gene

  • Protein details for KRT27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 27
    Protein Accession:

    Protein attributes for KRT27 Gene

    459 amino acids
    Molecular mass:
    49822 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT27 Gene

Proteomics data for KRT27 Gene at MOPED

Post-translational modifications for KRT27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT27 Gene

Domains & Families for KRT27 Gene

Gene Families for KRT27 Gene

Protein Domains for KRT27 Gene

Suggested Antigen Peptide Sequences for KRT27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT27: view

Function for KRT27 Gene

Molecular function for KRT27 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
genes like me logo Genes that share phenotypes with KRT27: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT27 Gene

Localization for KRT27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT27 Gene


Subcellular locations from

Jensen Localization Image for KRT27 Gene COMPARTMENTS Subcellular localization image for KRT27 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KRT27: view

Pathways & Interactions for KRT27 Gene

SuperPathways for KRT27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT27 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT27 Gene

Drugs & Compounds for KRT27 Gene

No Compound Related Data Available

Transcripts for KRT27 Gene

mRNA/cDNA for KRT27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT27 Gene

Keratin 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT27 Gene

No ASD Table

Relevant External Links for KRT27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT27 Gene

mRNA expression in normal human tissues for KRT27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x41.7) and Skin - Sun Exposed (Lower leg) (x8.6).

Protein differential expression in normal tissues from HIPED for KRT27 Gene

This gene is overexpressed in Hair follicle (25.9), Skin (18.0), Urine (8.3), Brain (6.7), and Bone marrow mesenchymal stem cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT27 Gene

SOURCE GeneReport for Unigene cluster for KRT27 Gene Hs.59363

mRNA Expression by UniProt/SwissProt for KRT27 Gene

Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).
genes like me logo Genes that share expression patterns with KRT27: view

Protein tissue co-expression partners for KRT27 Gene

- Elite partner

Primer Products

Orthologs for KRT27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT27 35
  • 87.87 (n)
  • 91.72 (a)
KRT27 36
  • 91 (a)
(Canis familiaris)
Mammalia KRT27 35
  • 90.34 (n)
  • 94.38 (a)
KRT27 36
  • 92 (a)
(Mus musculus)
Mammalia Krt27 35
  • 83.41 (n)
  • 88.62 (a)
Krt27 16
Krt27 36
  • 89 (a)
(Pan troglodytes)
Mammalia KRT27 35
  • 99.56 (n)
  • 99.56 (a)
KRT27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Krt27 35
  • 83.89 (n)
  • 89.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt16 35
  • 61.98 (n)
  • 57.03 (a)
Species with no ortholog for KRT27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT27 Gene

Gene Tree for KRT27 (if available)
Gene Tree for KRT27 (if available)

Paralogs for KRT27 Gene

genes like me logo Genes that share paralogs with KRT27: view

Variants for KRT27 Gene

Sequence variations from dbSNP and Humsavar for KRT27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17558560 - 40,780,407(+) CAAAC(C/T)ATTGA reference, missense
rs17558532 - 40,779,624(+) CGAGG(C/T)GCTCT reference, missense
rs2469826 - 40,782,339(-) GGGCA(C/G)CTCAT reference, missense
rs12453124 - 40,782,064(+) AAGTT(A/C/T)GTCAA reference, missense
rs981684 - 40,779,560(+) TCTCG(A/G)TAAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT27 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294
dgv3166n71 CNV Loss 21882294

Variation tolerance for KRT27 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.01; 99.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRT27 Gene

Disorders for KRT27 Gene

Relevant External Links for KRT27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT27 Gene

Publications for KRT27 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. (PMID: 15629149) Klammt J. … Kiess W. (Biochem. Biophys. Res. Commun. 2005) 3
  4. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3
  5. Protein-protein interaction panel using mouse full-length cDNAs. (PMID: 11591653) Suzuki H. … Hayashizaki Y. (Genome Res. 2001) 3

Products for KRT27 Gene

Sources for KRT27 Gene