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Aliases for KRT27 Gene

Aliases for KRT27 Gene

  • Keratin 27 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs3 3 4
  • Keratin 27, Type I 2 3
  • Cytokeratin-27 3 4
  • Keratin-25C 3 4
  • KRT25C 3 4
  • CK-27 3 4
  • K25C 3 4
  • K27 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs3 3
  • Keratin, Type I Cytoskeletal 27 3
  • Keratin 25C 2
  • Keratin-27 4
  • K25IRS3 3

External Ids for KRT27 Gene

Previous HGNC Symbols for KRT27 Gene

  • KRT25C

Previous GeneCards Identifiers for KRT27 Gene

  • GC17M036187
  • GC17M038933
  • GC17M034728

Summaries for KRT27 Gene

Entrez Gene Summary for KRT27 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT27 Gene

KRT27 (Keratin 27) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT25.

UniProtKB/Swiss-Prot for KRT27 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT27 Gene

Genomics for KRT27 Gene

Regulatory Elements for KRT27 Gene

Enhancers for KRT27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G040827 1.1 ENCODE 10.5 -46.0 -46047 2.9 PKNOX1 FOXA2 CREB3L1 ARNT FEZF1 ZNF2 ZNF766 ZNF143 JUNB REST KRT27 KRT23 MED24 PIR60311 KRT10
GH17G040846 1 FANTOM5 9.9 -64.4 -64429 0.1 ATF1 PKNOX1 ARNT ZNF766 GATA2 ELK1 KDM4B ZNF263 NCOA1 REST TMEM99 KRT10 KRT28 KRT27 KRT26 ENSG00000234477 KRT222 SMARCE1 KRTAP2-1 LOC105371777
GH17G040803 0.9 ENCODE 10.8 -21.2 -21190 0.2 ELF3 FOXA2 RB1 ARID4B DNMT3B ZNF2 ZNF48 ZSCAN9 RAD21 ZEB1 KRT27 KRT26 KRT222 SMARCE1 GC17M040770 LOC105371776
GH17G040707 0.9 ENCODE 10.2 +74.3 74301 1.4 TBP ELF3 ARID4B ZNF2 RAD21 SMARCC2 FOS RELB ZNF654 SMARCC1 KRT24 WIPF2 KRT27 KRT222 SMARCE1 KRT37 KRT223P
GH17G040825 0.7 ENCODE 10.5 -43.6 -43633 0.9 STAT1 JUN ZSCAN4 CEBPB EP300 ZNF592 ZNF664 NFIC ZNF366 IKZF1 TMEM99 KRT27 KRT23 MED24 KRT10 PIR60311
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT27 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT27 Gene

40,776,808 bp from pter
40,782,534 bp from pter
5,727 bases
Minus strand

Genomic View for KRT27 Gene

Genes around KRT27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT27 Gene

Proteins for KRT27 Gene

  • Protein details for KRT27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 27
    Protein Accession:

    Protein attributes for KRT27 Gene

    459 amino acids
    Molecular mass:
    49822 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT27 Gene

Post-translational modifications for KRT27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT27 Gene

Domains & Families for KRT27 Gene

Gene Families for KRT27 Gene

Protein Domains for KRT27 Gene

Suggested Antigen Peptide Sequences for KRT27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT27: view

Function for KRT27 Gene

Molecular function for KRT27 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

Gene Ontology (GO) - Molecular Function for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT27: view
genes like me logo Genes that share phenotypes with KRT27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT27 Gene

Localization for KRT27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT27 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT27 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT27: view

Pathways & Interactions for KRT27 Gene

SuperPathways for KRT27 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT27: view

Pathways by source for KRT27 Gene

2 Reactome pathways for KRT27 Gene

Gene Ontology (GO) - Biological Process for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031069 hair follicle morphogenesis IEA --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT27: view

No data available for SIGNOR curated interactions for KRT27 Gene

Drugs & Compounds for KRT27 Gene

No Compound Related Data Available

Transcripts for KRT27 Gene

mRNA/cDNA for KRT27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT27 Gene

Keratin 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT27 Gene

No ASD Table

Relevant External Links for KRT27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x41.7) and Skin - Sun Exposed (Lower leg) (x8.6).

Protein differential expression in normal tissues from HIPED for KRT27 Gene

This gene is overexpressed in Hair follicle (25.9), Skin (18.0), Urine (8.3), Brain (6.7), and Bone marrow mesenchymal stem cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT27 Gene

Protein tissue co-expression partners for KRT27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT27 Gene:


SOURCE GeneReport for Unigene cluster for KRT27 Gene:


mRNA Expression by UniProt/SwissProt for KRT27 Gene:

Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).

Evidence on tissue expression from TISSUES for KRT27 Gene

  • Intestine(2.1)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT27: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT27 Gene

Orthologs for KRT27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT27 34 35
  • 99.56 (n)
(Canis familiaris)
Mammalia KRT27 34 35
  • 90.34 (n)
(Bos Taurus)
Mammalia KRT27 34 35
  • 87.87 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Krt27 34
  • 83.89 (n)
(Mus musculus)
Mammalia Krt27 34 16 35
  • 83.41 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt16 34
  • 61.98 (n)
Species where no ortholog for KRT27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT27 Gene

Gene Tree for KRT27 (if available)
Gene Tree for KRT27 (if available)

Paralogs for KRT27 Gene

Variants for KRT27 Gene

Sequence variations from dbSNP and Humsavar for KRT27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000484362 -- 40,781,132(+) AATAA(A/G)GGAGA intron-variant
rs1001763237 -- 40,776,478(+) ACTTA(C/T)AGCCT downstream-variant-500B
rs1002036857 -- 40,783,735(+) TTTTG(C/T)AGAGT upstream-variant-2KB
rs1002089338 -- 40,783,389(+) CATTC(A/G)ATACT upstream-variant-2KB
rs1002158169 -- 40,783,933(+) TGTTA(C/T)TCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT27 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT27 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.01; 99.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT27 Gene

Disorders for KRT27 Gene

Relevant External Links for KRT27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT27 Gene

Publications for KRT27 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PMID: 16874310) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2006) 4 64

Products for KRT27 Gene

Sources for KRT27 Gene

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