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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT27 Gene

protein-coding   GIFtS: 42
GCID: GC17M038933

Keratin 27

(Previous name: keratin 25C)
(Previous symbol: KRT25C)
  Search for KRT27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 271 2     Keratin, Type I Cytoskeletal 272
KRT25C1 2 3     keratin-25C2
Keratin 25C1 2     keratin-272
Type I Inner Root Sheath-Specific Keratin-K25irs32 3     Type I Inner Root Sheath Specific Keratin 25 Irs32
CK-272 3     Cytokeratin-273
K25C2 3     Keratin-25C3
K272 3     Keratin-273
cytokeratin-272     

External Ids:    HGNC: 308411   Entrez Gene: 3425742   Ensembl: ENSG000001714467   UniProtKB: Q7Z3Y83   

Export aliases for KRT27 gene to outside databases

Previous GC identifers: GC17M036187 GC17M034728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT27 Gene:
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate
filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament.
These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells.
The type I keratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2009)

GeneCards Summary for KRT27 Gene: 
KRT27 (keratin 27) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of
keratin intermediate filaments in the inner root sheath (irs) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT27 gene promoter:
         POU2F1   POU2F1b   POU2F1a   HNF-1   COMP1   POU2F1c   AP-2gamma   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT27 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT27 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038933:  view genomic region     (about GC identifiers)

Start:
38,933,060 bp from pter      End:
38,938,786 bp from pter
Size:
5,727 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 27  
Size: 459 amino acids; 49822 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By
similarity)
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)

Explore the universe of human proteins at neXtProt for KRT27: NX_Q7Z3Y8

Explore proteomics data for KRT27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z3Y8

  • KRT27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT27 Protein Expression
    REFSEQ proteins: NP_853515.2  
    ENSEMBL proteins: 
     ENSP00000301656  

    Human Recombinant Protein Products for KRT27: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT27 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005882intermediate filament IEA--

    KRT27 for ontologies           About GeneDecksing



    KRT27 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for KRT27 
    Cloud-Clone Corp. CLIAs for KRT27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    3 InterPro protein domains:
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q7Z3Y8

    ProtoNet protein and cluster: Q7Z3Y8

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
    Similarity: Belongs to the intermediate filament family


    KRT27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C27_HUMAN, Q7Z3Y8
    Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of
    keratin intermediate filaments in the inner root sheath (irs) (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT27 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT27:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Krt27):
     integument 

    KRT27 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT27 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for KRT27 (Q7Z3Y83 ENSP000003016564) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT7P087293, ENSP000003292434I2D: score=2 STRING: ENSP00000329243
    INSRRP146163, ENSP000003571784I2D: score=1 STRING: ENSP00000357178
    IGF1RP080693, ENSP000002680354I2D: score=1 STRING: ENSP00000268035
    INSRP062133, ENSP000003038304I2D: score=1 STRING: ENSP00000303830
    RAB24Q969Q53, ENSP000003043764I2D: score=1 STRING: ENSP00000304376
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031069hair follicle morphogenesis IEA--

    KRT27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT27 (K1C27)

    Search CenterWatch for drugs/clinical trials and news about KRT27 / K1C27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT27 gene: 
    NM_181537.3  

    Unigene Cluster for KRT27:

    Keratin 27
    Hs.59363  [show with all ESTs]
    Unigene Representative Sequence: AJ564206
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540723 ENST00000301656(uc002hvg.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT27
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT27
    SwitchGear 3'UTR luciferase reporter plasmidKRT27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT27
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                         Customized lentivirus expression plasmids for stable overexpression of KRT27 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT27

    Additional mRNA sequence: 

    AF086481.1 AJ564206.1 

    2 DOTS entries:

    DT.40284925  DT.120986157 

    11 AceView cDNA sequences:

    BX105456 W93299 W92849 AF086481 BE386477 AJ564206 NM_181537 AI368013 
    AI160083 AI275141 AA339768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT27 expression in normal human tissues (normalized intensities)      KRT27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGAAAT
    KRT27 Expression
    About this image


    KRT27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Hair (Integumentary System)
             Fetal Inner Root Sheath Cells Inner Root Sheath

    See KRT27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT27

    SOURCE GeneReport for Unigene cluster: Hs.59363

    UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
    Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley
    layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to
    the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level)

        SABiosciences Custom PCR Arrays for KRT27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT27 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt271 , 5 keratin 271, 5 84.08(n)1
    89.29(a)1
      11 (62.92 cM)5
    166751  NM_010666.11  NP_034796.11 
     993455655 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    52(a)
    1 → many
    6(70390670-70404326)


    ENSEMBL Gene Tree for KRT27 (if available)
    TreeFam Gene Tree for KRT27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT27 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT132  KRT262  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/39 SIMAP similar genes for KRT27 using alignment to 1 protein entry:     K1C27_HUMAN(see all similar genes):
    KRT25    KRT28    KRT26    KRT10    KRT12    keratin
    JUP    KRT13    KRT24    KRT16    KRT15    KRT19
    KRT17    KRT14    KRT32    K14    KRT20    KRT31

    KRT27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 SNPs in KRT27 are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs569006871,2
    C--34729468(+) TTTTT-/T/TT  
            
    AAATG
    1 -- int11NA 2
    rs718586691,2
    C--34733890(+) ACCTC-/CTTAA 
            
    TTATT
    1 -- us2k10--------
    rs352791631,2
    C--34734171(+) TTTTT-/TGACAG 1 -- us2k10--------
    rs1850552921,2
    --38932877(+) TTTTCA/GTACTG 1 -- ds50010--------
    rs581505541,2
    C,F--38932913(+) AGAAGT/CCAAAA 1 -- ds50013Minor allele frequency- C:0.13WA CSA 122
    rs1891284721,2
    --38933051(+) AGAACA/CAGGGA 1 -- ds50010--------
    rs1449213581,2
    C--38933082(+) AACTTG/TTATTG 1 -- ut310--------
    rs1146046861,2
    C,F--38933139(+) AATAAC/TTTGTC 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs110789571,2
    C,H--38933167(+) AAGCAG/AAAAAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 406
    rs1119553361,2
    C--38933278(+) TTCTTG/ATTGTT 2 /N syn11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for KRT27 (38933060 - 38938786 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT27:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3166n71CNV Loss21882294
    nsv908226CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT27
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT27 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KRT27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
    3. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)2 Langbein L.... Schweizer J. (2006)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    5. Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. (PubMed id 15629149)1 Klammt J....Kiess W. (2005)
    6. Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (2001)
    7. Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. (PubMed id 10329736)1 Xu P....Taylor S.I. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 342574 HGNC: 30841 AceView: KRT25C Ensembl:ENSG00000171446 euGenes: HUgn342574
    ECgene: KRT27 H-InvDB: KRT27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT27 gene:
    Search GeneIP for patents involving KRT27

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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