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KRT27 Gene

protein-coding   GIFtS: 44
GCID: GC17M038933

Keratin 27

(Previous name: keratin 25C)
(Previous symbol: KRT25C)
  Search for KRT27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 271 2     Keratin, Type I Cytoskeletal 272
KRT25C1 2 3     keratin-25C2
Keratin 25C1 2     keratin-272
Type I Inner Root Sheath-Specific Keratin-K25irs32 3     Type I Inner Root Sheath Specific Keratin 25 Irs32
CK-272 3     Cytokeratin-273
K25C2 3     Keratin-25C3
K272 3     Keratin-273
cytokeratin-272     

External Ids:    HGNC: 308411   Entrez Gene: 3425742   Ensembl: ENSG000001714467   UniProtKB: Q7Z3Y83   

Export aliases for KRT27 gene to outside databases

Previous GC identifers: GC17M036187 GC17M034728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT27 Gene:
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate
filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament.
These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells.
The type I keratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2009)

GeneCards Summary for KRT27 Gene:
KRT27 (keratin 27) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of
keratin intermediate filaments in the inner root sheath (irs) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT27 gene promoter:
         POU2F1   POU2F1b   POU2F1a   HNF-1   COMP1   POU2F1c   AP-2gamma   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT27 promoter sequence
   Search Chromatin IP Primers for KRT27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT27 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038933:  view genomic region     (about GC identifiers)

Start:
38,933,060 bp from pter      End:
38,938,786 bp from pter
Size:
5,727 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 27  
Size: 459 amino acids; 49822 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By
similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)

Explore the universe of human proteins at neXtProt for KRT27: NX_Q7Z3Y8

Explore proteomics data for KRT27 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_853515.2  
    ENSEMBL proteins: 
     ENSP00000301656  

    KRT27 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for KRT27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    2 InterPro protein domains:
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q7Z3Y8

    ProtoNet protein and cluster: Q7Z3Y8

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
    Similarity: Belongs to the intermediate filament family


    KRT27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C27_HUMAN, Q7Z3Y8
    Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of
    keratin intermediate filaments in the inner root sheath (irs) (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
         
    KRT27 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT27:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Krt27):
     integument 

    KRT27 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT27
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT27
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT27

    miRNA
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    GenScript: all cDNA clones in your preferred vector: KRT27 (NM_181537)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT27

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    K1C27_HUMAN, Q7Z3Y8: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--
    GO:0005882intermediate filament IEA--

    KRT27 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT27
    Interactions:

        Search GeneGlobe Interaction Network for KRT27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KRT27 (Q7Z3Y83 ENSP000003016564) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT7P087293, ENSP000003292434I2D: score=2 STRING: ENSP00000329243
    INSRRP146163, ENSP000003571784I2D: score=1 STRING: ENSP00000357178
    IGF1RP080693, ENSP000002680354I2D: score=1 STRING: ENSP00000268035
    INSRP062133, ENSP000003038304I2D: score=1 STRING: ENSP00000303830
    RAB24Q969Q53, ENSP000003043764I2D: score=1 STRING: ENSP00000304376
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0031069hair follicle morphogenesis IEA--

    KRT27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT27 (K1C27)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT27 gene: 
    NM_181537.3  

    Unigene Cluster for KRT27:

    Keratin 27
    Hs.59363  [show with all ESTs]
    Unigene Representative Sequence: AJ564206
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540723 ENST00000301656(uc002hvg.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KRT27

    Additional mRNA sequence: 

    AF086481.1 AJ564206.1 

    2 DOTS entries:

    DT.40284925  DT.120986157 

    11 AceView cDNA sequences:

    BX105456 W93299 AF086481 W92849 NM_181537 AJ564206 BE386477 AI368013 
    AI160083 AI275141 AA339768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGAAAT
    KRT27 Expression
    About this image


    KRT27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Hair (Integumentary System)
             Fetal Inner Root Sheath Cells Inner Root Sheath
    KRT27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59363

    UniProtKB/Swiss-Prot: K1C27_HUMAN, Q7Z3Y8
    Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley
    layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to
    the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT27 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt271 , 5 keratin 271, 5 83.41(n)1
    88.62(a)1
      11 (62.92 cM)5
    166751  NM_010666.11  NP_034796.11 
     993455655 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia krt161 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) 61.98(n)
    57.03(a)
      100499212  XM_004918699.1  XP_004918756.1 


    ENSEMBL Gene Tree for KRT27 (if available)
    TreeFam Gene Tree for KRT27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT27 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT132  
    KRT262  KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  
    KRT33A2  
    Selected SIMAP similar genes for KRT27 using alignment to 1 protein entry:     K1C27_HUMAN(see all similar genes):
    KRT25    KRT28    KRT26    KRT10    KRT12    keratin
    JUP    KRT13    KRT24    KRT16    KRT15    KRT19
    KRT17    KRT14    KRT32    K14    KRT20    KRT31

    KRT27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT27 (see all 242)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs569006871,2
    C--34729468(+) TTTTT-/T/TT  
            
    AAATG
    1 -- int11NA 2
    rs718586691,2
    C--34733890(+) ACCTC-/CTTAA 
            
    TTATT
    1 -- us2k10--------
    rs352791631,2
    C--34734171(+) TTTTT-/TGACAG 1 -- us2k10--------
    rs1850552921,2
    --38932877(+) TTTTCA/GTACTG 1 -- ds50010--------
    rs581505541,2
    C,F--38932913(+) AGAAGT/CCAAAA 1 -- ds50013Minor allele frequency- C:0.13WA CSA 122
    rs1891284721,2
    --38933051(+) AGAACA/CAGGGA 1 -- ds50010--------
    rs1449213581,2
    C--38933082(+) AACTTG/TTATTG 1 -- ut310--------
    rs1146046861,2
    C,F--38933139(+) AATAAC/TTTGTC 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs110789571,2
    C,H--38933167(+) AAGCAG/AAAAAA 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 406
    rs1119553361,2
    C--38933278(+) TTCTTG/ATTGTT 2 /N syn11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for KRT27 (38933060 - 38938786 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT27:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3166n71CNV Loss21882294
    nsv908226CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT27
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT27 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KRT27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (Differentiation 2004)
    3. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)2 Langbein L.... Schweizer J. (J. Invest. Dermatol. 2006)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    5. Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. (PubMed id 15629149)1 Klammt J....Kiess W. (Biochem. Biophys. Res. Commun. 2005)
    6. Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (Genome Res. 2001)
    7. Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. (PubMed id 10329736)1 Xu P....Taylor S.I. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342574 HGNC: 30841 AceView: KRT25C Ensembl:ENSG00000171446 euGenes: HUgn342574
    ECgene: KRT27 H-InvDB: KRT27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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