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Aliases for KRT26 Gene

Aliases for KRT26 Gene

  • Keratin 26 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs2 3 4
  • Keratin 26, Type I 2 3
  • Cytokeratin-26 3 4
  • Keratin-25B 3 4
  • KRT25B 3 4
  • CK-26 3 4
  • K25B 3 4
  • K26 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs2 3
  • Keratin, Type I Cytoskeletal 26 3
  • Keratin 25B 2
  • Keratin-26 4
  • K25IRS2 3
  • CK26 3
  • K25 3

External Ids for KRT26 Gene

Previous HGNC Symbols for KRT26 Gene

  • KRT25B

Previous GeneCards Identifiers for KRT26 Gene

  • GC17M036176
  • GC17M038922
  • GC17M034716

Summaries for KRT26 Gene

Entrez Gene Summary for KRT26 Gene

  • The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT26 Gene

KRT26 (Keratin 26) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT27.

Additional gene information for KRT26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT26 Gene

Genomics for KRT26 Gene

GeneHancer (GH) Regulatory Elements for KRT26 Gene

Promoters and enhancers for KRT26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040772 Promoter 0.5 EPDnew 550.8 -0.1 -59 0.1 KRT26 KRT27 GC17M040770
GH17I040900 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.1 -130.6 -130636 5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 KRT23 SNORD124 KRT12 TMEM99 KRT28 KRTAP3-2 KRT40 KRT37 KRT38 KRT26
GH17I040803 Enhancer 0.9 ENCODE 10 -31.6 -31562 0.2 FOXA2 ARID4B ZNF2 ZNF48 ARID2 ZNF143 KLF13 DEK NCOA1 MXD4 KRT27 KRT26 KRT222 SMARCE1 GC17M040770 LOC105371776
GH17I040846 Enhancer 0.6 FANTOM5 9.6 -74.8 -74801 0.1 SCRT1 MAX CEBPB RFX5 POLR2A SCRT2 ZSCAN5C STAT3 TMEM99 KRT10 KRT28 KRT27 KRT26 ENSG00000234477 KRT222 SMARCE1 KRTAP2-1 LOC105371777
GH17I040896 Enhancer 0.2 dbSUPER 9.1 -124.7 -124706 1.2 ENSG00000234477 KRT12 KRT40 KRT28 TMEM99 KRT26 KRTAP3-1 KRT23 KRT20 GC17P040941
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT26 gene promoter:

Genomic Locations for KRT26 Gene

Genomic Locations for KRT26 Gene
5,925 bases
Minus strand

Genomic View for KRT26 Gene

Genes around KRT26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT26 Gene

Proteins for KRT26 Gene

  • Protein details for KRT26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 26
    Protein Accession:
    Secondary Accessions:
    • A2RUL2
    • B2RNH8

    Protein attributes for KRT26 Gene

    468 amino acids
    Molecular mass:
    51911 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT26 Gene

Post-translational modifications for KRT26 Gene

No Post-translational modifications

Other Protein References for KRT26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT26 Gene

Domains & Families for KRT26 Gene

Gene Families for KRT26 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT26 Gene

Suggested Antigen Peptide Sequences for KRT26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT26: view

Function for KRT26 Gene

Phenotypes From GWAS Catalog for KRT26 Gene

Gene Ontology (GO) - Molecular Function for KRT26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT26: view
genes like me logo Genes that share phenotypes with KRT26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT26

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT26 Gene

Localization for KRT26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT26 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with KRT26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT26 Gene

Pathways & Interactions for KRT26 Gene

SuperPathways for KRT26 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT26: view

Pathways by source for KRT26 Gene

2 Reactome pathways for KRT26 Gene

Interacting Proteins for KRT26 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000334798 Q7Z3Y9-K1C26_HUMAN for KRT26 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for KRT26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT26: view

No data available for SIGNOR curated interactions for KRT26 Gene

Drugs & Compounds for KRT26 Gene

No Compound Related Data Available

Transcripts for KRT26 Gene

mRNA/cDNA for KRT26 Gene

(1) REFSEQ mRNAs :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT26

Alternative Splicing Database (ASD) splice patterns (SP) for KRT26 Gene

No ASD Table

Relevant External Links for KRT26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT26 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x41.9) and Skin - Sun Exposed (Lower leg) (x8.1).

Protein differential expression in normal tissues from HIPED for KRT26 Gene

This gene is overexpressed in Skin (19.9), Blymphocyte (16.4), Heart (13.4), and Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT26 Gene

Protein tissue co-expression partners for KRT26 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT26 Gene:


SOURCE GeneReport for Unigene cluster for KRT26 Gene:


mRNA Expression by UniProt/SwissProt for KRT26 Gene:

Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present slightly above the apex of the dermal papilla (at protein level).

Evidence on tissue expression from TISSUES for KRT26 Gene

  • Intestine(2.4)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT26: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT26 Gene

Orthologs for KRT26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT26 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia KRT26 33 34
  • 84.48 (n)
(Bos Taurus)
Mammalia KRT26 33 34
  • 83.76 (n)
(Monodelphis domestica)
Mammalia KRT26 34
  • 81 (a)
(Mus musculus)
Mammalia Krt26 33 16 34
  • 79.08 (n)
(Rattus norvegicus)
Mammalia Krt26 33
  • 77.44 (n)
(Ornithorhynchus anatinus)
Mammalia KRT26 34
  • 77 (a)
Species where no ortholog for KRT26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT26 Gene

Gene Tree for KRT26 (if available)
Gene Tree for KRT26 (if available)

Paralogs for KRT26 Gene

Paralogs for KRT26 Gene

genes like me logo Genes that share paralogs with KRT26: view

Variants for KRT26 Gene

Sequence variations from dbSNP and Humsavar for KRT26 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000088128 -- 40,773,923(-) T/C upstream_transcript_variant
rs1000277020 -- 40,769,206(-) T/C intron_variant
rs1000529524 -- 40,770,801(-) C/T intron_variant
rs1000824915 -- 40,769,536(-) C/T intron_variant
rs1002823650 -- 40,772,249(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT26 Gene

Variant ID Type Subtype PubMed ID
dgv5589n54 CNV loss 21841781
nsv1146669 OTHER inversion 26484159
nsv574995 CNV loss 21841781

Variation tolerance for KRT26 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT26 Gene

Disorders for KRT26 Gene

Additional Disease Information for KRT26

No disorders were found for KRT26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT26 Gene

Publications for KRT26 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  2. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PMID: 16874310) Langbein L … Schweizer J (The Journal of investigative dermatology 2006) 3 4 58
  3. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 4 58
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  5. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PMID: 21800051) Fang Y … Shen X (Molecular and cellular biochemistry 2012) 3 58

Products for KRT26 Gene

Sources for KRT26 Gene

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