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KRT26 Gene

protein-coding   GIFtS: 44
GCID: GC17M038922

Keratin 26

(Previous name: keratin 25B)
(Previous symbol: KRT25B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 261 2     cytokeratin-262
KRT25B1 2 3     Keratin, Type I Cytoskeletal 262
Keratin 25B1 2     keratin-25B2
Type I Inner Root Sheath-Specific Keratin-K25irs22 3     keratin-262
CK-262 3     Type I Inner Root Sheath Specific Keratin 25 Irs22
K25B2 3     Cytokeratin-263
K262 3     Keratin-25B3
CK262     Keratin-263
K25IRS22     

External Ids:    HGNC: 308401   Entrez Gene: 3532882   Ensembl: ENSG000001863937   UniProtKB: Q7Z3Y93   

Export aliases for KRT26 gene to outside databases

Previous GC identifers: GC17M036176 GC17M034716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT26 Gene:
The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin
that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin
genes on chromosome 17q21. (provided by RefSeq, Jul 2009)

GeneCards Summary for KRT26 Gene:
KRT26 (keratin 26) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT26 gene promoter:
         Spz1   CUTL1   AP-2gamma   MZF-1   POU2F1a   COMP1   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT26 promoter sequence
   Search Chromatin IP Primers for KRT26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT26 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038922:  view genomic region     (about GC identifiers)

Start:
38,922,490 bp from pter      End:
38,928,414 bp from pter
Size:
5,925 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 26  
Size: 468 amino acids; 51911 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: A2RUL2 B2RNH8

Explore the universe of human proteins at neXtProt for KRT26: NX_Q7Z3Y9

Explore proteomics data for KRT26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_853517.2  
    ENSEMBL proteins: 
     ENSP00000334798  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    2 InterPro protein domains:
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q7Z3Y9

    ProtoNet protein and cluster: Q7Z3Y9

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT26           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT26:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KRT26

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    Find genes that share ontologies with KRT26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT26
    Interactions:

        Search GeneGlobe Interaction Network for KRT26

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KRT26 (Q7Z3Y93 ENSP000003347984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT26 (K1C26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT26 gene: 
    NM_181539.4  

    Unigene Cluster for KRT26:

    Keratin 26
    Hs.592133
    Unigene Representative Sequence: AJ564205
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335552(uc002hvf.3)
    miRNA
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    hsa-miR-518a-5p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ564205.2 BC132951.1 BC136896.1 

    1 DOTS entry:

    DT.100737397 

    15 AceView cDNA sequences:

    NM_181534 AJ564204 W20364 AI088272 AK129503 NM_181539 W73634 AI150703 
    BX110062 AJ564205 AI150740 W73682 W35097 W67642 W67826 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTATGCAT
    KRT26 Expression
    About this image


    KRT26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
    KRT26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592133

    UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9
    Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In
    the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present
    slightly above the apex of the dermal papilla (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KRT26 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt261 , 5 keratin 261, 5 79.08(n)1
    78.14(a)1
      11 (62.92 cM)5
    3208641  NM_001033397.51  NP_001028569.21 
     993285505 


    ENSEMBL Gene Tree for KRT26 (if available)
    TreeFam Gene Tree for KRT26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT26 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  
    KRT132  KRT102  KRT122  KRT352  KRT152  KRT242  KRT33B2  KRT92  
    KRT33A2  
    Selected SIMAP similar genes for KRT26 using alignment to 1 protein entry:     K1C26_HUMAN(see all similar genes):
    KRT27    KRT28    KRT25    KRT10    KRT13    KRT15
    KRT12    JUP    KRT14    KRT16    KRT24    keratin
    KRT19    KRT17    KRT9    KRT40    KRT31    KRT32

    Find genes that share paralogs with KRT26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT26 (see all 247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007483061,2
    C--34717102(-) AGAAAA/GAGAGA 1 -- ut310--------
    rs352535951,2
    C--38922719(+) TTCTT-/TCTCTCT 1 -- ut311Minor allele frequency- TC:0.50NA 2
    rs595852921,2
    C--38922720(+) TCTCT-/CTTTCTT 1 -- ut311Minor allele frequency- CT:0.00NA 2
    rs2012259061,2
    C--38922720(+) TCTTTC/TTCTCT 1 -- ut310--------
    rs58203601,2
    C--38925100(+) TGAGG-/TTTTTT 1 -- int1 trp32Minor allele frequency- T:0.25NA 4
    rs353795751,2
    C--38928719(+) CCCCC-/TGCCAC 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1488887801,2
    --39708929(+) ATCCCA/TGCTGC 1 -- ds50010--------
    rs1455456091,2
    C--39709068(+) AGATGC/TATGTG 1 -- ds50010--------
    rs1381423921,2
    C--39709134(+) ATCACC/TCAGGC 1 -- ds50010--------
    rs80688141,2
    C,F,H--39709214(+) ACTCAA/GACCCA 1 -- ds50019Minor allele frequency- G:0.02NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for KRT26 (38922490 - 38928414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT26:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3166n71CNV Loss21882294
    nsv908226CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KRT26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)1, 2 Langbein L.... Schweizer J. (J. Invest. Dermatol. 2006)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    3. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (Differentiation 2004)
    4. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353288 HGNC: 30840 AceView: KRT25A Ensembl:ENSG00000186393 euGenes: HUgn353288
    ECgene: KRT26 H-InvDB: KRT26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT26 gene:
    Search GeneIP for patents involving KRT26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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