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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT26 Gene

protein-coding   GIFtS: 41
GCID: GC17M038922

Keratin 26

(Previous name: keratin 25B)
(Previous symbol: KRT25B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 261 2     cytokeratin-262
KRT25B1 2 3     Keratin, Type I Cytoskeletal 262
Keratin 25B1 2     keratin-25B2
Type I Inner Root Sheath-Specific Keratin-K25irs22 3     keratin-262
CK-262 3     Type I Inner Root Sheath Specific Keratin 25 Irs22
K25B2 3     Cytokeratin-263
K262 3     Keratin-25B3
CK262     Keratin-263
K25IRS22     

External Ids:    HGNC: 308401   Entrez Gene: 3532882   Ensembl: ENSG000001863937   UniProtKB: Q7Z3Y93   

Export aliases for KRT26 gene to outside databases

Previous GC identifers: GC17M036176 GC17M034716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT26 Gene:
The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin
that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin
genes on chromosome 17q21. (provided by RefSeq, Jul 2009)

GeneCards Summary for KRT26 Gene: 
KRT26 (keratin 26) is a protein-coding gene. Diseases associated with KRT26 include hepatocellular carcinoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT26 gene promoter:
         Spz1   CUTL1   AP-2gamma   MZF-1   POU2F1a   COMP1   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT26 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT26 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038922:  view genomic region     (about GC identifiers)

Start:
38,922,490 bp from pter      End:
38,928,414 bp from pter
Size:
5,925 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 26  
Size: 468 amino acids; 51911 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: A2RUL2 B2RNH8

Explore the universe of human proteins at neXtProt for KRT26: NX_Q7Z3Y9

Explore proteomics data for KRT26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z3Y9

  • KRT26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT26 Protein Expression
    REFSEQ proteins: NP_853517.2  
    ENSEMBL proteins: 
     ENSP00000334798  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    KRT26 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    3 InterPro protein domains:
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q7Z3Y9

    ProtoNet protein and cluster: Q7Z3Y9

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9
    Similarity: Belongs to the intermediate filament family


    KRT26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT26 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT26:
     Increased gamma-H2AX phosphory 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT26

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KRT26 (Q7Z3Y93 ENSP000003347984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT26 (K1C26)

    Search CenterWatch for drugs/clinical trials and news about KRT26 / K1C26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT26 gene: 
    NM_181539.4  

    Unigene Cluster for KRT26:

    Keratin 26
    Hs.592133
    Unigene Representative Sequence: AJ564205
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335552(uc002hvf.3)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT26:
    hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT26 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for KRT26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT26
    Clone
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    OriGene ORF clones in mouse, rat for KRT26
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT26

    Additional mRNA sequence: 

    AJ564205.2 BC132951.1 BC136896.1 

    1 DOTS entry:

    DT.100737397 

    15 AceView cDNA sequences:

    NM_181534 W20364 AJ564204 AI088272 NM_181539 AI150703 AI150740 BX110062 
    W73634 AK129503 AJ564205 W73682 W35097 W67642 W67826 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT26 expression in normal human tissues (normalized intensities)      KRT26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTATGCAT
    KRT26 Expression
    About this image


    KRT26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath

    See KRT26 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.592133

    UniProtKB/Swiss-Prot: K1C26_HUMAN, Q7Z3Y9
    Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In
    the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present
    slightly above the apex of the dermal papilla (at protein level)

        SABiosciences Custom PCR Arrays for KRT26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT26 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt261 , 5 keratin 261, 5 79(n)1
    78.14(a)1
      11 (62.92 cM)5
    3208641  NM_001033397.51  NP_001028569.21 
     993285505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    47(a)
    1 → many
    6(70390670-70404326)


    ENSEMBL Gene Tree for KRT26 (if available)
    TreeFam Gene Tree for KRT26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT26 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT132  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/32 SIMAP similar genes for KRT26 using alignment to 1 protein entry:     K1C26_HUMAN(see all similar genes):
    KRT27    KRT28    KRT25    KRT10    KRT13    KRT15
    KRT12    JUP    KRT14    KRT16    KRT24    keratin
    KRT19    KRT17    KRT9    KRT40    KRT31    KRT32

    KRT26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 SNPs in KRT26 are shown (see all 247)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007483061,2
    C--34717102(-) AGAAAA/GAGAGA 1 -- ut310--------
    rs352535951,2
    C--38922719(+) TTCTT-/TCTCTCT 1 -- ut311Minor allele frequency- TC:0.50NA 2
    rs595852921,2
    C--38922720(+) TCTCT-/CTTTCTT 1 -- ut311Minor allele frequency- CT:0.00NA 2
    rs2012259061,2
    C--38922720(+) TCTTTC/TTCTCT 1 -- ut310--------
    rs58203601,2
    C--38925100(+) TGAGG-/TTTTTT 1 -- int1 trp32Minor allele frequency- T:0.25NA 4
    rs353795751,2
    C--38928719(+) CCCCC-/TGCCAC 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1488887801,2
    --39708929(+) ATCCCA/TGCTGC 1 -- ds50010--------
    rs1455456091,2
    C--39709068(+) AGATGC/TATGTG 1 -- ds50010--------
    rs1381423921,2
    C--39709134(+) ATCACC/TCAGGC 1 -- ds50010--------
    rs80688141,2
    C,F,H--39709214(+) ACTCAA/GACCCA 1 -- ds50019Minor allele frequency- G:0.02NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for KRT26 (38922490 - 38928414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT26:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3166n71CNV Loss21882294
    nsv908226CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for KRT26:    About MalaCards
    hepatocellular carcinoma    


    KRT26 for disorders           About GeneDecksing


    Export disorders for KRT26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT26 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KRT26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)1, 2 Langbein L.... Schweizer J. (2006)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    3. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
    4. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353288 HGNC: 30840 AceView: KRT25A Ensembl:ENSG00000186393 euGenes: HUgn353288
    ECgene: KRT26 H-InvDB: KRT26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT26 gene:
    Search GeneIP for patents involving KRT26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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