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Aliases for KRT25 Gene

Aliases for KRT25 Gene

  • Keratin 25 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs1 3 4
  • Keratin 25, Type I 2 3
  • Cytokeratin-25 3 4
  • Keratin-25A 3 4
  • Keratin-25 3 4
  • KRT25A 3 4
  • CK-25 3 4
  • K25A 3 4
  • K25 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs1 3
  • Keratin, Type I Cytoskeletal 25 3
  • Keratin 25A 2
  • KRT24IRS1 3
  • ARWH3 3

External Ids for KRT25 Gene

Previous HGNC Symbols for KRT25 Gene

  • KRT25A

Previous GeneCards Identifiers for KRT25 Gene

  • GC17M036159
  • GC17M038904
  • GC17M034698

Summaries for KRT25 Gene

Entrez Gene Summary for KRT25 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT25 Gene

KRT25 (Keratin 25) is a Protein Coding gene. Diseases associated with KRT25 include Woolly Hair Autosomal Recessive 3 and Hypotrichosis 8. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT27.

UniProtKB/Swiss-Prot for KRT25 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT25 Gene

Genomics for KRT25 Gene

Regulatory Elements for KRT25 Gene

Enhancers for KRT25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KRT25 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT25 Gene

Chromosome:
17
Start:
40,748,021 bp from pter
End:
40,755,542 bp from pter
Size:
7,522 bases
Orientation:
Minus strand

Genomic View for KRT25 Gene

Genes around KRT25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT25 Gene

Proteins for KRT25 Gene

  • Protein details for KRT25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z0-K1C25_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 25
    Protein Accession:
    Q7Z3Z0

    Protein attributes for KRT25 Gene

    Size:
    450 amino acids
    Molecular mass:
    49318 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins (PubMed:26902920). Interacts with KRT6A to form filaments (By similarity).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT25 Gene

Post-translational modifications for KRT25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT25 Gene

Domains & Families for KRT25 Gene

Gene Families for KRT25 Gene

Protein Domains for KRT25 Gene

Suggested Antigen Peptide Sequences for KRT25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3Z0

UniProtKB/Swiss-Prot:

K1C25_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT25: view

Function for KRT25 Gene

Molecular function for KRT25 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920).

Gene Ontology (GO) - Molecular Function for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IEA --
GO:0046982 protein heterodimerization activity IDA 26902920
genes like me logo Genes that share ontologies with KRT25: view

Phenotypes for KRT25 Gene

genes like me logo Genes that share phenotypes with KRT25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT25 Gene

Localization for KRT25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT25 Gene COMPARTMENTS Subcellular localization image for KRT25 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT25: view

Pathways & Interactions for KRT25 Gene

SuperPathways for KRT25 Gene

No Data Available

Interacting Proteins for KRT25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310573%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000364898%0d%0a
Selected Interacting proteins: ENSP00000310573 Q7Z3Z0-K1C25_HUMAN for KRT25 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IDA 26902920
GO:0007568 aging IDA 21916889
GO:0031069 hair follicle morphogenesis IEA --
GO:0042633 hair cycle IDA 21916889
GO:0045109 intermediate filament organization IEA --
genes like me logo Genes that share ontologies with KRT25: view

No data available for Pathways by source and SIGNOR curated interactions for KRT25 Gene

Drugs & Compounds for KRT25 Gene

No Compound Related Data Available

Transcripts for KRT25 Gene

mRNA/cDNA for KRT25 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT25 Gene

Keratin 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT25 Gene

No ASD Table

Relevant External Links for KRT25 Gene

GeneLoc Exon Structure for
KRT25
ECgene alternative splicing isoforms for
KRT25

Expression for KRT25 Gene

mRNA expression in normal human tissues for KRT25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT25 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.0) and Skin - Sun Exposed (Lower leg) (x8.4).

Protein differential expression in normal tissues from HIPED for KRT25 Gene

This gene is overexpressed in Hair follicle (57.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT25 Gene



Protein tissue co-expression partners for KRT25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT25 Gene:

KRT25

SOURCE GeneReport for Unigene cluster for KRT25 Gene:

Hs.55412

mRNA Expression by UniProt/SwissProt for KRT25 Gene:

Q7Z3Z0-K1C25_HUMAN
Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).
genes like me logo Genes that share expression patterns with KRT25: view

Primer Products

Orthologs for KRT25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT25 34
  • 90.07 (n)
  • 92.89 (a)
KRT25 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT25 34
  • 89.78 (n)
  • 93.33 (a)
KRT25 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt25 34
  • 87.29 (n)
  • 91.93 (a)
Krt25 16
Krt25 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRT25 34
  • 99.19 (n)
  • 98.67 (a)
KRT25 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt25 34
  • 86.7 (n)
  • 90.81 (a)
oppossum
(Monodelphis domestica)
Mammalia KRT25 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT25 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
Species where no ortholog for KRT25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT25 Gene

ENSEMBL:
Gene Tree for KRT25 (if available)
TreeFam:
Gene Tree for KRT25 (if available)

Paralogs for KRT25 Gene

genes like me logo Genes that share paralogs with KRT25: view

Variants for KRT25 Gene

Sequence variations from dbSNP and Humsavar for KRT25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12951399 - 40,755,111(+) CTCCC(A/G)ATGAG reference, missense
rs1048227 -- 40,748,283(-) CAAAG(C/T)AATTA reference, synonymous-codon
rs2109217 -- 40,752,940(+) GCAAT(A/C)CTAAA intron-variant
rs2429540 -- 40,751,862(+) TATGT(A/G)TGTGT intron-variant
rs2191210 -- 40,756,271(+) AACCC(C/T)ATCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT25 Gene

Variant ID Type Subtype PubMed ID
dgv5589n54 CNV loss 21841781
nsv1146669 OTHER inversion 26484159
nsv574995 CNV loss 21841781
nsv574996 CNV loss 21841781

Variation tolerance for KRT25 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT25 Gene

Human Gene Mutation Database (HGMD)
KRT25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT25 Gene

Disorders for KRT25 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KRT25 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
woolly hair autosomal recessive 3
  • arwh3
hypotrichosis 8
  • woolly hair, autosomal recessive 1, with or without hypotrichosis
woolly hair syndrome
  • woolly hair
woolly hair, autosomal recessive
hypotrichosis
- elite association - COSMIC cancer census association via MalaCards
Search KRT25 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

K1C25_HUMAN
  • Woolly hair autosomal recessive 3 (ARWH3) [MIM:616760]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. {ECO:0000269 PubMed:26160856, ECO:0000269 PubMed:26902920}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT25

Genetic Association Database (GAD)
KRT25
Human Genome Epidemiology (HuGE) Navigator
KRT25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT25
genes like me logo Genes that share disorders with KRT25: view

No data available for Genatlas for KRT25 Gene

Publications for KRT25 Gene

  1. Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles. (PMID: 26902920) Zernov N.V. … Zinchenko R.A. (J. Invest. Dermatol. 2016) 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 65
  4. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4 65
  5. A homozygous missense variant in type I keratin KRT25 causes autosomal recessive woolly hair. (PMID: 26160856) Ansar M. … Leal S.M. (J. Med. Genet. 2015) 4 65

Products for KRT25 Gene

Sources for KRT25 Gene

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