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Aliases for KRT25 Gene

Aliases for KRT25 Gene

  • Keratin 25 2 3
  • Keratin 25, Type I 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs1 3 4
  • Cytokeratin-25 3 4
  • Keratin 25A 2 3
  • Keratin-25A 3 4
  • Keratin-25 3 4
  • KRT25A 3 4
  • CK-25 3 4
  • K25A 3 4
  • K25 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs1 3
  • KRT24IRS1 3
  • ARWH3 3

External Ids for KRT25 Gene

Previous HGNC Symbols for KRT25 Gene

  • KRT25A

Previous GeneCards Identifiers for KRT25 Gene

  • GC17M036159
  • GC17M038904
  • GC17M034698

Summaries for KRT25 Gene

Entrez Gene Summary for KRT25 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT25 Gene

KRT25 (Keratin 25) is a Protein Coding gene. Diseases associated with KRT25 include hypotrichosis 8 and woolly hair syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT12.

UniProtKB/Swiss-Prot for KRT25 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT25 Gene

Genomics for KRT25 Gene

Regulatory Elements for KRT25 Gene

Enhancers for KRT25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT25 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT25 Gene

Chromosome:
17
Start:
40,748,021 bp from pter
End:
40,755,542 bp from pter
Size:
7,522 bases
Orientation:
Minus strand

Genomic View for KRT25 Gene

Genes around KRT25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT25 Gene

Proteins for KRT25 Gene

  • Protein details for KRT25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z0-K1C25_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 25
    Protein Accession:
    Q7Z3Z0

    Protein attributes for KRT25 Gene

    Size:
    450 amino acids
    Molecular mass:
    49318 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT25 Gene

Proteomics data for KRT25 Gene at MOPED

Post-translational modifications for KRT25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT25 Gene

Domains & Families for KRT25 Gene

Gene Families for KRT25 Gene

Protein Domains for KRT25 Gene

Suggested Antigen Peptide Sequences for KRT25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3Z0

UniProtKB/Swiss-Prot:

K1C25_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT25: view

Function for KRT25 Gene

Molecular function for KRT25 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

Gene Ontology (GO) - Molecular Function for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT25: view

Phenotypes for KRT25 Gene

genes like me logo Genes that share phenotypes with KRT25: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT25 Gene

Localization for KRT25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT25 Gene COMPARTMENTS Subcellular localization image for KRT25 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KRT25: view

Pathways & Interactions for KRT25 Gene

SuperPathways for KRT25 Gene

No Data Available

Interacting Proteins for KRT25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310573%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000364898%0d%0a
Selected Interacting proteins: ENSP00000310573 for KRT25 Gene via STRING

Gene Ontology (GO) - Biological Process for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042633 hair cycle IDA 21916889
genes like me logo Genes that share ontologies with KRT25: view

No data available for Pathways by source and SIGNOR curated interactions for KRT25 Gene

Drugs & Compounds for KRT25 Gene

No Compound Related Data Available

Transcripts for KRT25 Gene

mRNA/cDNA for KRT25 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT25 Gene

Keratin 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT25 Gene

No ASD Table

Relevant External Links for KRT25 Gene

GeneLoc Exon Structure for
KRT25
ECgene alternative splicing isoforms for
KRT25

Expression for KRT25 Gene

mRNA expression in normal human tissues for KRT25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT25 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.0) and Skin - Sun Exposed (Lower leg) (x8.4).

Protein differential expression in normal tissues from HIPED for KRT25 Gene

This gene is overexpressed in Hair follicle (57.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT25 Gene



SOURCE GeneReport for Unigene cluster for KRT25 Gene Hs.55412

mRNA Expression by UniProt/SwissProt for KRT25 Gene

Q7Z3Z0-K1C25_HUMAN
Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).
genes like me logo Genes that share expression patterns with KRT25: view

Protein tissue co-expression partners for KRT25 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KRT25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT25 35
  • 90.07 (n)
  • 92.89 (a)
KRT25 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT25 35
  • 89.78 (n)
  • 93.33 (a)
KRT25 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt25 35
  • 87.29 (n)
  • 91.93 (a)
Krt25 16
Krt25 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRT25 35
  • 99.19 (n)
  • 98.67 (a)
KRT25 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt25 35
  • 86.7 (n)
  • 90.81 (a)
oppossum
(Monodelphis domestica)
Mammalia KRT25 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT25 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
Species with no ortholog for KRT25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT25 Gene

ENSEMBL:
Gene Tree for KRT25 (if available)
TreeFam:
Gene Tree for KRT25 (if available)

Paralogs for KRT25 Gene

genes like me logo Genes that share paralogs with KRT25: view

Variants for KRT25 Gene

Sequence variations from dbSNP and Humsavar for KRT25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12951399 - 40,755,111(+) CTCCC(A/G)ATGAG reference, missense
rs1048227 -- 40,748,283(-) CAAAG(C/T)AATTA reference, synonymous-codon
rs2109217 -- 40,752,940(+) GCAAT(A/C)CTAAA intron-variant
rs2191210 -- 40,756,271(+) AACCC(C/T)ATCTC upstream-variant-2KB
rs2429540 -- 40,751,862(+) TATGT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT25 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294
nsv908227 CNV Loss 21882294
dgv3166n71 CNV Loss 21882294

Variation tolerance for KRT25 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT25 Gene

HapMap Linkage Disequilibrium report
KRT25
Human Gene Mutation Database (HGMD)
KRT25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT25 Gene

Disorders for KRT25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KRT25 Gene - From: ClinVar and Orphanet

Disorder Aliases PubMed IDs
hypotrichosis 8
  • woolly hair, autosomal recessive 1, with or without hypotrichosis
woolly hair syndrome
  • familial woolly hair
- elite association - COSMIC cancer census association via MalaCards
Search KRT25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT25

Genetic Association Database (GAD)
KRT25
Human Genome Epidemiology (HuGE) Navigator
KRT25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT25
genes like me logo Genes that share disorders with KRT25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT25 Gene

Publications for KRT25 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Hair greying is associated with active hair growth. (PMID: 21916889) Choi H.I. … Lee Y.H. (Br. J. Dermatol. 2011) 3
  5. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M. … Magin T.M. (Eur. J. Cell Biol. 2004) 3

Products for KRT25 Gene

Sources for KRT25 Gene

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