KRT25 Gene
protein-coding GIFtS: 41
GCID: GC17M038904
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keratin 25(Previous name: keratin 25A )
(Previous symbol: KRT25A)
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Aliases
for KRT25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 251 2 | | Keratin, Type I Cytoskeletal 252 | | KRT25A1 2 3 | | Keratin-253 | | Keratin 25A1 2 | | Keratin-25A3 | | Type I Inner Root Sheath-Specific Keratin-K25irs12 3 | | Type I Inner Root Sheath Specific Keratin 25 Irs12 | | CK-252 3 | | Cytokeratin-253 | | K252 3 | | Keratin-253 | | K25A2 3 | | Keratin-25A3 | | Cytokeratin-253 | | |
Export aliases for KRT25 gene to outside databasesPrevious GC identifers: GC17M036159 GC17M034698 |
Summaries
for KRT25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT25:
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediatefilament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. Thesefilaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type Ikeratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2009)
UniProtKB/Swiss-Prot: K1C25_HUMAN, Q7Z3Z0Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratinintermediate filaments in the inner root sheath (irs) (By similarity)
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Genomic Views
for KRT25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT25 gene promoter:
Spz1 NCX/Ncx HTF AP-2gamma MZF-1 PPAR-gamma1 S8 c-Myb PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KRT25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M038904: view genomic region
(about GC identifiers)
Start:
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38,904,273 bp from pter |
End:
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38,911,584 bp from pter |
Size:
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7,312 bases |
Orientation:
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minus strand |
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Proteins
for KRT25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K1C25_HUMAN, Q7Z3Z0 (See
protein sequence)Recommended Name: Keratin, type I cytoskeletal 25 Size: 450 amino acids; 49318 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity)
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)Explore the universe of human proteins at neXtProt for KRT25: NX_Q7Z3Z0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z3Z0
KRT25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_853512.1
ENSEMBL proteins: ENSP00000310573
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0005882 | intermediate filament |
IEA | -- |
KRT25 for ontologies About GeneDecksing
KRT25 Antibody Products:
Assay Products for KRT25: |
Protein
Domains /
Families
for KRT25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT25 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z3Z0ProtoNet protein and cluster: Q7Z3Z0 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1C25_HUMAN, Q7Z3Z0Similarity: Belongs to the intermediate filament family |
Function
for KRT25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: K1C25_HUMAN, Q7Z3Z0Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratinintermediate filaments in the inner root sheath (irs) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT25 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
KRT25 for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Krt25):
KRT25 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KRT25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT25
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for KRT25 (ENSP000003105734) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031069 | hair follicle morphogenesis |
IEA | -- | | GO:0045109 | intermediate filament organization |
IEA | -- |
KRT25 for ontologies About GeneDecksing
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Drugs & Compounds
for KRT25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT25
Search CenterWatch for drugs/clinical trials and news about KRT25 / K1C25
|
Transcripts
for KRT25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT25 gene: NM_181534.3 Unigene Cluster for KRT25: Keratin 25 Hs.55412 [show with all ESTs]Unigene Representative Sequence: NM_1815341 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000312150(uc002hve.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT25 (NM_181534) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT25 |
Additional cDNA sequence: AJ564204.1 AK129503.1 1 DOTS entry: DT.95184218 15 AceView cDNA sequences: W20364 AI088272 AJ564204 NM_181534 NM_181539 AI150740 AK129503 AI150703 AJ564205 W73634 BX110062 W73682 W35097 W67642 W67826
GeneLoc Exon Structure
|
Expression
for KRT25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAAGAAAA
About this image
See KRT25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT25
SOURCE GeneReport for Unigene cluster: Hs.55412
UniProtKB/Swiss-Prot: K1C25_HUMAN, Q7Z3Z0Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In thehair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle.Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in themedulla of beard hair (at protein level)
SABiosciences Custom PCR Arrays for KRT25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT25 |
Orthologs
for KRT25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT25 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KRT25 (if available)
TreeFam Gene Tree for KRT25 (if available) |
Paralogs
for KRT25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT25 gene
- KRT172 KRT132 KRT162 KRT262 KRT102 KRT122 KRT182 KRT272
- KRT152 KRT202 KRT242 KRT192 KRT92 KRT282 KRT142 KRT232
18/33 SIMAP similar genes for KRT25 using alignment to 1 protein entry: K1C25_HUMAN(see all similar genes):KRT27 KRT28 KRT26 KRT10 KRT19 KRT15
KRT24 keratin JUP KRT13 KRT12 KRT14
KRT16 KRT9 KRT40 KRT17 KRT33A KRT33B
KRT25 for paralogs About GeneDecksing
|
Genomic Variants
for KRT25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT25 (38904273 - 38911584 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT25 |
|
Disorders
/ Diseases
for KRT25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KRT25 for disorders About MalaCards
KRT25 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: KRT25 (1 document)
Export disorders for KRT25 gene to outside databases
|
Publications
for KRT25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)2 Langbein L.... Schweizer J. (2006)
- Comprehensive analysis of keratin gene clusters in humans and rodents. (PubMed id 15085952)1 Hesse M.... Magin T.M. (2004)
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External Searches for KRT25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT25 gene:
Search GeneIP for patents involving KRT25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT25 | | | OriGene Protein Over-expression Lysate for KRT25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT25 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT25 |
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 | | | KRT25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT25 |
|  |  |  | | | | Search ThermoFisher Antibodies for KRT25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT25 |
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