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Aliases for KRT25 Gene

Aliases for KRT25 Gene

  • Keratin 25, Type I 2 3
  • Type I Inner Root Sheath-Specific Keratin-K25irs1 3 4
  • Cytokeratin-25 3 4
  • Keratin 25A 2 3
  • Keratin-25A 3 4
  • Keratin-25 3 4
  • KRT25A 3 4
  • CK-25 3 4
  • K25A 3 4
  • K25 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs1 3
  • Keratin, Type I Cytoskeletal 25 3
  • Keratin 25 2

External Ids for KRT25 Gene

Previous Symbols for KRT25 Gene

  • KRT25A

Summaries for KRT25 Gene

Entrez Gene Summary for KRT25 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT25 Gene

KRT25 (Keratin 25, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot for KRT25 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT25 Gene

Genomics for KRT25 Gene

Genomic Location for KRT25 Gene

Start:
40,748,021 bp from pter
End:
40,755,332 bp from pter
Size:
7,312 bases
Orientation:
Minus strand

Genomic View for KRT25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT25 Gene

Regulatory Elements for KRT25 Gene

Proteins for KRT25 Gene

  • Protein details for KRT25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z0-K1C25_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 25
    Protein Accession:
    Q7Z3Z0
    Secondary Accessions:

    Protein attributes for KRT25 Gene

    Size:
    450 amino acids
    Molecular mass:
    49318 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT25 Gene

Proteomics data for KRT25 Gene at MOPED

Post-translational modifications for KRT25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT25 Gene

Domains for KRT25 Gene

Gene Families for KRT25 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT25 Gene

UniProtKB/Swiss-Prot:

K1C25_HUMAN
Family:
  • Belongs to the intermediate filament family.:
    • Q7Z3Z0
genes like me logo Genes that share domains with KRT25: view

Function for KRT25 Gene

Molecular function for KRT25 Gene

UniProtKB/Swiss-Prot Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

Gene Ontology (GO) - Molecular Function for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KRT25: view
genes like me logo Genes that share phenotypes with KRT25: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT25 Gene

Localization for KRT25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT25 Gene COMPARTMENTS Subcellular localization image for KRT25 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT25: view

Pathways for KRT25 Gene

SuperPathways for KRT25 Gene

No Data Available

Interacting Proteins for KRT25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310573%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000364898%0d%0a
Selected Interacting proteins: ENSP00000310573 for KRT25 Gene via STRING

Gene Ontology (GO) - Biological Process for KRT25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IDA 21916889
GO:0031069 hair follicle morphogenesis IEA --
GO:0042633 hair cycle IDA 21916889
GO:0045109 intermediate filament organization IEA --
genes like me logo Genes that share ontologies with KRT25: view

No data available for Pathways by source for KRT25 Gene

Transcripts for KRT25 Gene

mRNA/cDNA for KRT25 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT25 Gene

Keratin 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT25 Gene

No ASD Table

Relevant External Links for KRT25 Gene

GeneLoc Exon Structure for
KRT25
ECgene alternative splicing isoforms for
KRT25

Expression for KRT25 Gene

mRNA expression in normal human tissues for KRT25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT25 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (42.0) and Skin - Sun Exposed (Lower leg) (8.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT25 Gene

SOURCE GeneReport for Unigene cluster for KRT25 Gene Hs.55412

mRNA Expression by UniProt/SwissProt for KRT25 Gene

Q7Z3Z0-K1C25_HUMAN
Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).
genes like me logo Genes that share expressions with KRT25: view

Orthologs for KRT25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT25 36
  • 99.19 (n)
  • 98.67 (a)
KRT25 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT25 36
  • 90.07 (n)
  • 92.89 (a)
KRT25 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT25 36
  • 89.78 (n)
  • 93.33 (a)
KRT25 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt25 36
  • 87.29 (n)
  • 91.93 (a)
Krt25 16
Krt25 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT25 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT25 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt25 36
  • 86.7 (n)
  • 90.81 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
ManyToMany
Species with no ortholog for KRT25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT25 Gene

ENSEMBL:
Gene Tree for KRT25 (if available)
TreeFam:
Gene Tree for KRT25 (if available)

Paralogs for KRT25 Gene

genes like me logo Genes that share paralogs with KRT25: view

Variants for KRT25 Gene

Sequence variations from dbSNP and Humsavar for KRT25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1048227 -- 40,748,283(-) CAAAG(C/T)AATTA reference, synonymous-codon
rs2109217 -- 40,752,940(+) GCAAT(A/C)CTAAA intron-variant
rs2191210 -- 40,756,271(+) AACCC(C/T)ATCTC upstream-variant-2KB
rs2429540 -- 40,751,862(+) TATGT(A/G)TGTGT intron-variant
rs4890127 -- 40,747,995(+) ATAAA(C/T)ATTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRT25 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294
nsv908227 CNV Loss 21882294
dgv3166n71 CNV Loss 21882294

Relevant External Links for KRT25 Gene

HapMap Linkage Disequilibrium report
KRT25
Human Gene Mutation Database (HGMD)
KRT25

Disorders for KRT25 Gene

Relevant External Links for KRT25

Genetic Association Database (GAD)
KRT25
Human Genome Epidemiology (HuGE) Navigator
KRT25
genes like me logo Genes that share disorders with KRT25: view

No data available for UniProtKB/Swiss-Prot for KRT25 Gene

Publications for KRT25 Gene

  1. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Hair greying is associated with active hair growth. (PMID: 21916889) Choi H.I. … Lee Y.H. (Br. J. Dermatol. 2011) 3

Products for KRT25 Gene

Sources for KRT25 Gene

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