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Aliases for KRT24 Gene

Aliases for KRT24 Gene

  • Keratin 24 2 3 5
  • Keratin 24, Type I 2 3
  • Type I Keratin-24 3 4
  • Cytokeratin-24 3 4
  • CK-24 3 4
  • KA24 3 4
  • K24 3 4
  • Keratin, Type I Cytoskeletal 24 3
  • Keratin-24 4

External Ids for KRT24 Gene

Previous GeneCards Identifiers for KRT24 Gene

  • GC00U991194
  • GC17U900029
  • GC17M039228
  • GC17M039229
  • GC17M036108
  • GC17M038854
  • GC17M034648

Summaries for KRT24 Gene

Entrez Gene Summary for KRT24 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

GeneCards Summary for KRT24 Gene

KRT24 (Keratin 24) is a Protein Coding gene. Diseases associated with KRT24 include Naegeli-Franceschetti-Jadassohn Syndrome. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT10.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT24 Gene

Genomics for KRT24 Gene

Regulatory Elements for KRT24 Gene

Enhancers for KRT24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G040707 0.9 ENCODE 36.1 -4.5 -4484 1.4 TBP ELF3 ARID4B ZNF2 RAD21 SMARCC2 FOS RELB ZNF654 SMARCC1 KRT24 WIPF2 KRT27 KRT222 SMARCE1 KRT37 KRT223P
GH17G040726 0.8 ENCODE 12 -24.1 -24146 1.9 TBP BMI1 FEZF1 RAD21 RFX5 YY1 RELB ETV6 IKZF2 CREM KRT24 TMEM99 KRT28 KRT222 SMARCE1 KRT37 KRT223P KRT25
GH17G040088 2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +608.4 608403 14.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MSL1 MED1 ENSG00000266469 MED24 GSDMA CDK12 THRA ENSG00000266208 RARA PGAP3
GH17G040515 2 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +183.7 183680 9.6 CREB3L1 MLX DMAP1 FEZF1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 SNORD124 TOP2A CDC6 CCR7 IGFBP4 RPL23AP75 GJD3 RARA MSL1 SMARCE1
GH17G040660 0.3 FANTOM5 22.1 +42.7 42716 0.4 SMARCE1 KRT24 ENSG00000264058
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT24 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT24 Gene

Chromosome:
17
Start:
40,697,991 bp from pter
End:
40,703,750 bp from pter
Size:
5,760 bases
Orientation:
Minus strand

Genomic View for KRT24 Gene

Genes around KRT24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT24 Gene

Proteins for KRT24 Gene

  • Protein details for KRT24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2I5-K1C24_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 24
    Protein Accession:
    Q2M2I5
    Secondary Accessions:
    • Q9NXG7

    Protein attributes for KRT24 Gene

    Size:
    525 amino acids
    Molecular mass:
    55087 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT24 Gene

Post-translational modifications for KRT24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT24 Gene

No data available for DME Specific Peptides for KRT24 Gene

Domains & Families for KRT24 Gene

Gene Families for KRT24 Gene

Suggested Antigen Peptide Sequences for KRT24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M2I5

UniProtKB/Swiss-Prot:

K1C24_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT24: view

Function for KRT24 Gene

Molecular function for KRT24 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in the mucosa of patients suffering of colorectal cancer.

Gene Ontology (GO) - Molecular Function for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT24: view
genes like me logo Genes that share phenotypes with KRT24: view

Animal Model Products

miRNA for KRT24 Gene

miRTarBase miRNAs that target KRT24

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT24 Gene

Localization for KRT24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT24 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 3

Gene Ontology (GO) - Cellular Components for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT24 Gene

Pathways & Interactions for KRT24 Gene

SuperPathways for KRT24 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT24: view

Pathways by source for KRT24 Gene

2 Reactome pathways for KRT24 Gene

Interacting Proteins for KRT24 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264651%0d%0a9606.ENSP00000261537%0d%0a9606.ENSP00000426103%0d%0a9606.ENSP00000364898%0d%0a9606.ENSP00000264972%0d%0a9606.ENSP00000341268%0d%0a
Selected Interacting proteins: ENSP00000264651 Q2M2I5-K1C24_HUMAN for KRT24 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT24: view

No data available for SIGNOR curated interactions for KRT24 Gene

Drugs & Compounds for KRT24 Gene

No Compound Related Data Available

Transcripts for KRT24 Gene

mRNA/cDNA for KRT24 Gene

Unigene Clusters for KRT24 Gene

Keratin 24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT24 Gene

No ASD Table

Relevant External Links for KRT24 Gene

GeneLoc Exon Structure for
KRT24
ECgene alternative splicing isoforms for
KRT24

Expression for KRT24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT24 Gene

This gene is overexpressed in Esophagus - Mucosa (x42.4).

Protein differential expression in normal tissues from HIPED for KRT24 Gene

This gene is overexpressed in Skin (25.6), Cervix (17.9), and Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT24 Gene



Protein tissue co-expression partners for KRT24 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT24 Gene:

KRT24

SOURCE GeneReport for Unigene cluster for KRT24 Gene:

Hs.87383

mRNA Expression by UniProt/SwissProt for KRT24 Gene:

Q2M2I5-K1C24_HUMAN
Tissue specificity: Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis.

Evidence on tissue expression from TISSUES for KRT24 Gene

  • Gall bladder(5)
  • Intestine(4.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with KRT24: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT24 Gene

Orthologs for KRT24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT24 34 35
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia KRT24 34 35
  • 87.55 (n)
cow
(Bos Taurus)
Mammalia KRT24 34 35
  • 86.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Krt24 34
  • 79.68 (n)
mouse
(Mus musculus)
Mammalia Krt24 34 16 35
  • 79.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRT24 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT24 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487269 34
  • 66.09 (n)
Species where no ortholog for KRT24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT24 Gene

ENSEMBL:
Gene Tree for KRT24 (if available)
TreeFam:
Gene Tree for KRT24 (if available)

Paralogs for KRT24 Gene

Pseudogenes.org Pseudogenes for KRT24 Gene

genes like me logo Genes that share paralogs with KRT24: view

Variants for KRT24 Gene

Sequence variations from dbSNP and Humsavar for KRT24 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000112551 -- 40,698,875(+) AGCTA(A/T)TTTTT intron-variant
rs1000575503 -- 40,694,228(+) TCCAG(C/G)CTGGG intron-variant, downstream-variant-500B
rs1001591765 -- 40,702,750(+) TGTGT(A/C)AGTCT intron-variant
rs1001738220 -- 40,701,811(+) ATTTT(A/T)CTCCC intron-variant
rs1001871686 -- 40,704,358(+) AAACA(C/T)AAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT24 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT24 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.60; 98.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT24 Gene

Human Gene Mutation Database (HGMD)
KRT24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT24 Gene

Disorders for KRT24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT24 Gene - From: GeneCards

Disorder Aliases PubMed IDs
naegeli-franceschetti-jadassohn syndrome
  • naegeli syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KRT24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT24
genes like me logo Genes that share disorders with KRT24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT24 Gene

Publications for KRT24 Gene

  1. Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes. (PMID: 12230514) Sprecher E. … Richard G. (J. Invest. Dermatol. 2002) 3 4 22 64
  2. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. (PMID: 17317818) Hong Y. … Cheah P.Y. (Clin. Cancer Res. 2007) 3 4 64
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for KRT24 Gene

Sources for KRT24 Gene

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