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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT24 Gene

protein-coding GIFtS: 49
GCID: GC17M038854

keratin 24

Explore 6 diseases affiliated with
KRT24 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 24¹ ²		MGC138173¹
Type I Keratin-24² ³		Cytokeratin-24³
CK-24² ³		Keratin, Type I Cytoskeletal 24²
K24² ³		Keratin-24³
KA24² ³		Cytokeratin-24³
FLJ20261¹ ⁵		Keratin-24³
MGC138169¹

External Ids:	HGNC: 18527¹	Entrez Gene: 192666²	Ensembl: ENSG00000167916⁷	OMIM: 607742⁵	UniProtKB: Q2M2I5³

Export aliases for KRT24 gene to outside databases

Previous GC identifers: GC00U991194 GC17U900029 GC17M039228 GC17M039229 GC17M036108 GC17M034648

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT24:

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate

filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These

filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I

keratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jun 2009)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT24 gene promoter:
Oct-B1 C/EBPbeta Nkx2-5 AP-4 CUTL1 LCR-F1 RORalpha2 RORalpha1 FOXC1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT24 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT24

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT24

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q11.2

KRT24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT24 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M038854: view genomic region (about GC identifiers)

Start:	38,854,243 bp from pter	End:	38,860,002 bp from pter
Size:	5,760 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1C24_HUMAN, Q2M2I5 (See protein sequence)

Recommended Name: Keratin, type I cytoskeletal 24

Size: 525 amino acids; 55087 Da

Subunit: Heterotetramer of two type I and two type II keratins

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)

(40-55 and 56-70 kDa, respectively)

Secondary accessions: Q9NXG7

Explore the universe of human proteins at neXtProt for KRT24: NX_Q2M2I5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q2M2I5

KRT24 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061889.2

ENSEMBL proteins:

ENSP00000264651

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005882	intermediate filament	IEA	--
GO:0045111	intermediate filament cytoskeleton	IDA	--

KRT24 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT24 for domains About GeneDecksing

5 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR009053 Prefoldin

IPR016044 F

Graphical View of Domain Structure for InterPro Entry Q2M2I5

ProtoNet protein and cluster: Q2M2I5

2 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

UniProtKB/Swiss-Prot: K1C24_HUMAN, Q2M2I5

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K1C24_HUMAN, Q2M2I5

Induction: Up-regulated in the mucosa of patients suffering of colorectal cancer

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--

KRT24 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KRT24:

Increased S DNA content

Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KRT24

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/41 Interacting proteins for KRT24 (Q2M2I5³ ENSP00000264651⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP1LC3B	Q9GZQ8³, ENSP00000268607⁴	I2D: score=1 STRING: ENSP00000268607
GABARAPL1	Q9H0R8³	I2D: score=2
MAP1LC3A	Q9H492³	I2D: score=2
AMBRA1	Q9C0C7³	I2D: score=1
ATG10	Q9H0Y0³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT24
Search CenterWatch for drugs/clinical trials and news about KRT24 / K1C24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KRT24 gene:

NM_019016.2

Unigene Cluster for KRT24:

Keratin 24

Hs.87383 [show with all ESTs]

Unigene Representative Sequence: AK000268

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264651(uc002hvd.3)

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Additional cDNA sequence:

AK000268.1 BC111964.1 BC111968.1

3 DOTS entries:

DT.40117810 DT.100760343 DT.92419569

24/25 AceView cDNA sequences (see all 25):

BU685476 AA234933 CR609628 AA234932 BM726381 CR607026 BM681555 AI373805

BX390566 NM_019016 AK000268 AI128031 BV184034 AL577554 BX100314 BX399643

BX339197 BE181957 AI373145 AW366801 AA889092 BE181968 AA422013 BE182037

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATCCAGGG

About this image

KRT24 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

nGnG Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

See KRT24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT24

SOURCE GeneReport for Unigene cluster: Hs.87383

UniProtKB/Swiss-Prot: K1C24_HUMAN, Q2M2I5

Tissue specificity: Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus

and testis

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KRT24 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	KRT24⁶	--	49(a)	1 → many	6(70403614-70423453)
African clawed frog (Xenopus laevis)	Amphibia	AB086829.1²	--	74.97(n)		AB086829.1
zebrafish (Danio rerio)	Actinopterygii	zgc:109868⁶ cyt1⁶ (see all 15)	type I cytokeratin, enveloping layer (see all 15)	51(a) 50(a) (see all 15)	many ↔ many many ↔ many (see all 15)	19(5974115-5976185) 19(5986623-5988852)

ENSEMBL Gene Tree for KRT24 (if available)
TreeFam Gene Tree for KRT24 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT24 gene

KRT17² KRT16² KRT18² KRT25² KRT27² KRT20² KRT19² KRT28²

KRT14² KRT13² KRT26² KRT10² KRT12² KRT15² KRT9² KRT23²

18/41 SIMAP similar genes for KRT24 using alignment to 1 protein entry: K1C24_HUMAN(see all similar genes):

KRT19 keratin KRT13 KRT10 KRT15 KRT12

KRT25 KRT27 KRT31 KRT33A JUP KRT16

KRT35 KRT26 KRT32 KRT40 KRT14 KRT28

KRT24 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KRT24
PGOHUM00000237070

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111229668^1,2		--	34648158(+)	`GACGCT/GCTTGG`	1	--	int¹		1		CSA	1
rs78115646^1,2	C,F,	--	34648397(+)	`CTAGCC/TGTCTT`	1	--	int¹		1		NA	120
rs16966134^1,2	C,F,H,	--	34649958(+)	`CAAGTC/GTAAGC`	1	--	int¹		11		NA NS EA WA CSA	688
rs111458674^1,2		--	34650470(+)	`TCTATT/AATCAT`	1	--	int¹		1		CSA	2
rs8068810^1,2	C,F,H,	--	34650471(+)	`CTATAA/GTCATA`	1	--	int¹		5		NS EA WA	538
rs74542796^1,2	C,	--	34650851(+)	`GGCGGG/TTTTGC`	2	N T	mis¹		0	--	--	--	--
rs79328812^1,2	C,	--	34650854(+)	`GGTTTC/TGCTCA`	2	Q R	mis¹		0	--	--	--	--
rs35562924^1,2	C,	--	34651184(+)	`TTACC-/TTTTTT`	1	--	int¹		1		NA	2
rs2159429^1,2	C,F,	--	34652030(+)	`TCTTGG/AGAAAT`	1	--	int¹		1		WA	118
rs78446812^1,2	C,	--	34652464(+)	`TCTGG-/AATTGT`	3	P A S	fra¹ mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KRT24 (38854243 - 38860002 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KRT24
1 CNV: 39201

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT24

DNA2.0 Custom Variant and Variant Library Synthesis for KRT24

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT24 for disorders           About GeneDecksing

OMIM gene information: 607742    OMIM disorders: --

6 diseases for KRT24:    About MalaCards

naegeli-franceschetti-jadassohn syndrome hereditary mucosal leukokeratosis palmoplantar keratosis hypohidrosis

keratosis colorectal cancer

1 disease from the University of Copenhagen DISEASES database for KRT24:

Hypohidrosis

Export disorders for KRT24 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRT24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT24)

Utopia: connect your pdf to the dynamic
world of online information

Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes. (PubMed id 12230514)^{1, 2, 9} Sprecher E.... Richard G. (2002)
A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. (PubMed id 17317818)^{1, 2} Hong Y.... Cheah P.Y. (2007)
New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 3} Schweizer J....Wright M.W. (2006)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 192666	HGNC: 18527	AceView: KRT24	Ensembl:ENSG00000167916	euGenes: HUgn192666
ECgene: KRT24	H-InvDB: KRT24

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT24	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KRT24 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KRT24 gene:
Search GeneIP for patents involving KRT24

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for KRT24
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT24
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT24
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT24
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT24
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT24
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT24

	GenScript Custom Purified and Recombinant Proteins Services for KRT24		GenScript cDNA clones with any tag delivered in your preferred vector for KRT24
	GenScript Custom Assay Services for KRT24		GenScript Custom Superior Antibodies Services for KRT24
	GenScript Custom overexpressing Cell Line Services for KRT24		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT24

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KRT24 gene at Home site.

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KRT24 Gene

keratin 24

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KRT24 Gene

keratin 24

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