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Aliases for KRT24 Gene

Aliases for KRT24 Gene

  • Keratin 24, Type I 2 3
  • Type I Keratin-24 3 4
  • Cytokeratin-24 3 4
  • Keratin-24 3 4
  • CK-24 3 4
  • KA24 3 4
  • K24 3 4
  • Keratin, Type I Cytoskeletal 24 3
  • Keratin 24 2
  • FLJ20261 6

External Ids for KRT24 Gene

Previous GeneCards Identifiers for KRT24 Gene

  • GC00U991194
  • GC17U900029
  • GC17M039228
  • GC17M039229
  • GC17M036108
  • GC17M038854
  • GC17M034648

Summaries for KRT24 Gene

Entrez Gene Summary for KRT24 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

GeneCards Summary for KRT24 Gene

KRT24 (Keratin 24, Type I) is a Protein Coding gene. Diseases associated with KRT24 include naegeli-franceschetti-jadassohn syndrome and hypohidrosis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT24 Gene

Genomics for KRT24 Gene

Regulatory Elements for KRT24 Gene

Genomic Location for KRT24 Gene

40,697,991 bp from pter
40,703,750 bp from pter
5,760 bases
Minus strand

Genomic View for KRT24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT24 Gene

Proteins for KRT24 Gene

  • Protein details for KRT24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 24
    Protein Accession:
    Secondary Accessions:
    • Q9NXG7

    Protein attributes for KRT24 Gene

    525 amino acids
    Molecular mass:
    55087 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

neXtProt entry for KRT24 Gene

Proteomics data for KRT24 Gene at MOPED

Post-translational modifications for KRT24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT24 Gene

Domains for KRT24 Gene

Gene Families for KRT24 Gene

  • IFF1 :Intermediate filaments type I, keratins (acidic)

Suggested Antigen Peptide Sequences for KRT24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2M2I5
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT24: view

Function for KRT24 Gene

Molecular function for KRT24 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in the mucosa of patients suffering of colorectal cancer.

Gene Ontology (GO) - Molecular Function for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT24: view

Phenotypes for KRT24 Gene

GenomeRNAi human phenotypes for KRT24:
genes like me logo Genes that share phenotypes with KRT24: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT24 Gene

Localization for KRT24 Gene

Subcellular locations from

Jensen Localization Image for KRT24 Gene COMPARTMENTS Subcellular localization image for KRT24 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005882 intermediate filament IEA --
GO:0045111 intermediate filament cytoskeleton IDA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT24 Gene

Pathways for KRT24 Gene

SuperPathways for KRT24 Gene

No Data Available

Interacting Proteins for KRT24 Gene

Gene Ontology (GO) - Biological Process for KRT24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRT24: view

No data available for Pathways by source for KRT24 Gene

Transcripts for KRT24 Gene

mRNA/cDNA for KRT24 Gene

Unigene Clusters for KRT24 Gene

Keratin 24:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT24

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT24 Gene

No ASD Table

Relevant External Links for KRT24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT24 Gene

mRNA expression in normal human tissues for KRT24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT24 Gene

This gene is overexpressed in Esophagus - Mucosa (42.4).

Protein differential expression in normal tissues for KRT24 Gene

This gene is overexpressed in Skin (25.6), Cervix (17.9), and Heart (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT24 Gene

SOURCE GeneReport for Unigene cluster for KRT24 Gene Hs.87383

mRNA Expression by UniProt/SwissProt for KRT24 Gene

Tissue specificity: Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis.
genes like me logo Genes that share expressions with KRT24: view

Expression partners for KRT24 Gene

In Situ Assay Products

Orthologs for KRT24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT24 35
  • 86.68 (n)
  • 85.82 (a)
KRT24 36
  • 83 (a)
(Canis familiaris)
Mammalia KRT24 35
  • 87.55 (n)
  • 87.98 (a)
KRT24 36
  • 83 (a)
(Mus musculus)
Mammalia Krt24 35
  • 79.59 (n)
  • 74.39 (a)
Krt24 16
Krt24 36
  • 72 (a)
(Pan troglodytes)
Mammalia KRT24 35
  • 98.73 (n)
  • 97.33 (a)
KRT24 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Krt24 35
  • 79.68 (n)
  • 76.78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia KRT24 36
  • 77 (a)
(Anolis carolinensis)
Reptilia KRT24 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487269 35
  • 66.09 (n)
  • 65.22 (a)
Species with no ortholog for KRT24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT24 Gene

Gene Tree for KRT24 (if available)
Gene Tree for KRT24 (if available)

Paralogs for KRT24 Gene Pseudogenes for KRT24 Gene

genes like me logo Genes that share paralogs with KRT24: view

Variants for KRT24 Gene

Sequence variations from dbSNP and Humsavar for KRT24 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs874889 - 40,701,194(-) GAGAT(G/T)CAGAT reference, missense
rs887376 -- 40,700,410(+) TATCG(C/T)GATGC intron-variant
rs2011870 -- 40,700,633(-) ctggg(C/T)gacag intron-variant
rs2109224 -- 40,700,834(+) ctgat(C/G)tcatg intron-variant
rs2159428 -- 40,699,306(+) caggc(C/T)tgagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT24 Gene

Variant ID Type Subtype PubMed ID
nsv908225 CNV Loss 21882294

Relevant External Links for KRT24 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT24 Gene

Disorders for KRT24 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KRT24 Gene in MalaCards »

(2) Diseases for KRT24 Gene including...

(1) University of Copenhagen DISEASES for KRT24 Gene

genes like me logo Genes that share disorders with KRT24: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for KRT24 Gene

Publications for KRT24 Gene

  1. Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes. (PMID: 12230514) Sprecher E. … Richard G. (J. Invest. Dermatol. 2002) 3 4 23
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. (PMID: 17317818) Hong Y. … Cheah P.Y. (Clin. Cancer Res. 2007) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for KRT24 Gene

Sources for KRT24 Gene

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