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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT23 Gene

protein-coding   GIFtS: 54
GCID: GC17M039078

Keratin 23 (Histone Deacetylase Inducible)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 23 (Histone Deacetylase Inducible)1 2     Histone Deacetylase Inducible Keratin 232
CK-232 3     Hyperacetylation-Inducible Type I Keratin2
K232 3     Keratin, Type I Cytoskeletal 232
CK232     keratin-232
HAIK12     Type I Intermediate Filament Cytokeratin2
Cytokeratin 232     Cytokeratin-233
cytokeratin-232     Keratin-233

External Ids:    HGNC: 64381   Entrez Gene: 259842   Ensembl: ENSG000001082447   OMIM: 6061945   UniProtKB: Q9C0753   

Export aliases for KRT23 gene to outside databases

Previous GC identifers: GC17M041254 GC17M038987 GC17M039452 GC17M036332 GC17M034873


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT23 Gene:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic
keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for KRT23 Gene: 
KRT23 (keratin 23 (histone deacetylase inducible)) is a protein-coding gene. Diseases associated with KRT23 include aggressive periodontitis, and periodontitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is BFSP2.

Gene Wiki entry for KRT23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT23 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   Evi-1   C/EBPalpha   YY1   POU2F1   POU2F1a   NF-AT1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KRT23 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT23 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039078:  view genomic region     (about GC identifiers)

Start:
39,078,948 bp from pter      End:
39,093,886 bp from pter
Size:
14,939 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 23  
Size: 422 amino acids; 48131 Da
Subunit: Heterotetramer of two type I and two type II keratins (By similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: A8K084 Q9NUR6

Explore the universe of human proteins at neXtProt for KRT23: NX_Q9C075

Explore proteomics data for KRT23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C075

  • KRT23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT23 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269362.1  NP_056330.3  

    ENSEMBL proteins: 
     ENSP00000209718   ENSP00000414056   ENSP00000462335   ENSP00000464548   ENSP00000464051  
     ENSP00000467393  

    Human Recombinant Protein Products for KRT23: 
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    OriGene Protein Over-expression Lysate for KRT23
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    Novus Biologicals KRT23 Protein
    Novus Biologicals KRT23 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT23 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    KRT23 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for KRT23 
    Cloud-Clone Corp. CLIAs for KRT23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q9C075

    ProtoNet protein and cluster: Q9C075

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002017 Spectrin repeat
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075
    Similarity: Belongs to the intermediate filament family


    KRT23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT23 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KRT23:
     Cell division defect  Decreased cell number, increas  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT23 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT23 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT23 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT23
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT23
    SwitchGear 3'UTR luciferase reporter plasmidKRT23 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT23
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of KRT23 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KRT23 (Q9C0753 ENSP000002097184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    PRKAB1Q9Y4783I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT23 (K1C23)

    Search CenterWatch for drugs/clinical trials and news about KRT23 / K1C23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT23 gene (3 alternative transcripts): 
    NM_001282433.1  NM_015515.4  NM_173213.1  

    Unigene Cluster for KRT23:

    Keratin 23 (histone deacetylase inducible)
    Hs.9029  [show with all ESTs]
    Unigene Representative Sequence: NM_015515
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209718(uc002hvm.1 uc002hvn.1) ENST00000436344(uc010wfl.1)
    ENST00000462312(uc010cxf.1) ENST00000582754(uc010cxg.3) ENST00000494691
    ENST00000584517 ENST00000485751 ENST00000582283 ENST00000585006
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT23
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT23
    SwitchGear 3'UTR luciferase reporter plasmidKRT23 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT23
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    OriGene clones in human, mouse for KRT23 (see all 7)
    OriGene ORF clones in mouse, rat for KRT23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT23 (NM_015515)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT23
    Sirion Biotech Customized lentivirus for stable overexpression of KRT23 
                         Customized lentivirus expression plasmids for stable overexpression of KRT23 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT23
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT23
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT23

    Additional mRNA sequence: 

    AF075083.1 AF102848.1 AK002047.1 AK225866.1 AK289449.1 AK302109.1 AK310880.1 AK314604.1 
    BC028356.2 

    13 DOTS entries:

    DT.95176320  DT.446021  DT.100830363  DT.120920236  DT.120920249  DT.86852611  DT.100830359  DT.95176319 
    DT.100773211  DT.100830355  DT.120920237  DT.91739504  DT.95176298 

    24/232 AceView cDNA sequences (see all 232):

    CA310718 CR611999 AU137923 AF075083 CR617267 NM_015515 AW994770 CR606308 
    CR612571 AI270332 CR607165 BV177635 CR596166 CR608150 CR590444 CA314807 
    CR608577 H52528 CR618444 CR611282 AI219287 CR618027 CR595740 CR599508 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT23    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                    -     -                                             
    SP3:                                                                        


    ECgene alternative splicing isoforms for KRT23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT23 expression in normal human tissues (normalized intensities)      KRT23 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCAATGA
    KRT23 Expression
    About this image


    KRT23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Oral Cavity (Gastrointestinal Tract)
             Salivary gland   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

    See KRT23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT23

    SOURCE GeneReport for Unigene cluster: Hs.9029
        SABiosciences Custom PCR Arrays for KRT23
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT23 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt231 , 5 keratin 231, 5 82.66(n)1
    79.1(a)1
      11 (62.92 cM)5
    941791  NM_033373.11  NP_203537.11 
     994779745 
    chicken
    (Gallus gallus)
    Aves KRT231 keratin 23 (histone deacetylase inducible) 62.64(n)
    53.37(a)
      420044  XM_418167.3  XP_418167.3 
    lizard
    (Anolis carolinensis)
    Reptilia KRT236
    --
    --
    44(a)
    35(a)
    1 ↔ 1
    possible ortholog
    6(70518981-70553001)
    6(70918797-70935409)
    zebrafish
    (Danio rerio)
    Actinopterygii cyt16
    cyt1l6
    (see all 18)
    type I cytokeratin, enveloping layer, like
    (see all 18)
    41(a)
    40(a)
    (see all 18)
    1 ↔ many
    1 ↔ many
    (see all 18)
    19(5986623-5988852)
    19(5980624-5982658)


    ENSEMBL Gene Tree for KRT23 (if available)
    TreeFam Gene Tree for KRT23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT23 gene
    BFSP22  KRT202  KRT182  
    18/39 SIMAP similar genes for KRT23 using alignment to 5 protein entries:     K1C23_HUMAN (see all proteins) (see all similar genes):
    DKFZp434G032    type I hair keratin    JUP    GUCA1B    KRT31    keratin
    KRT16    K14    KRT33A    KRT33B    KRT34    KRT15
    KRT19    KRT9    KRT13    KRT17    KRT32    KRT20

    KRT23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/454 SNPs in KRT23 are shown (see all 454)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs762526981,2
    C--39078588(+) CTTAGA/TGTAGC 1 -- ds50010--------
    rs799646501,2
    C--39078590(+) TAGAGA/TAGCCT 1 -- ds50010--------
    rs1874800191,2
    --39078657(+) GCATAA/CTTTTT 1 -- ds50010--------
    rs1392274711,2
    --39078686(+) GTGAGG/TCTTTC 1 -- ds50010--------
    rs99088001,2
    C--39078701(+) CCTCCC/TTTTCT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1499853521,2
    --39078771(+) CATGAA/CTCATG 1 -- ds50010--------
    rs22698621,2
    C,F,A,H--39078825(-) TCACGG/TCAGCC 1 -- ds500126Minor allele frequency- T:0.17EA NS NA WA 4442
    rs1904710681,2
    --39078826(+) GCTGCC/TGTGAA 1 -- ds50010--------
    rs175683111,2
    C,F,H--39078845(+) ATGTCT/CGGAGA 1 -- ds500115Minor allele frequency- C:0.04NA NS EA WA 2024
    rs22698611,2
    C,F,O,A,H--39078939(-) TGTCTC/TTTTTT 1 -- ds500137Minor allele frequency- T:0.44EA NA NS WA CSA 4982

    HapMap Linkage Disequilibrium report for KRT23 (39078948 - 39093886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KRT23:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv9550CNV Loss18304495

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT23
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606194    OMIM disorders: --

    6 diseases for KRT23:    About MalaCards
    aggressive periodontitis    periodontitis    pancreatic cancer    colon cancer
    pancreatitis    lung cancer


    KRT23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KRT23
    Human Genome Epidemiology (HuGE) Navigator: KRT23 (5 documents)

    Export disorders for KRT23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT23 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with KRT23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. (PubMed id 11135429)1, 2, 3, 9 Zhang J.-S.... Smith D.I. (2001)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    4. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    7. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    8. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (PubMed id 15081423)1, 4 Suzuki A....Kamoi K. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Keratin 23, a novel DPC4/Smad4 target gene which bind s 14-3-3I/. (PubMed id 21492476)1 Liffers S.T....Hahn S.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25984 HGNC: 6438 AceView: KRT23 Ensembl:ENSG00000108244 euGenes: HUgn25984
    ECgene: KRT23 H-InvDB: KRT23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT23 gene:
    Search GeneIP for patents involving KRT23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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