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Aliases for KRT23 Gene

Aliases for KRT23 Gene

  • Keratin 23, Type I 2 3
  • Keratin 23 (Histone Deacetylase Inducible) 2 3
  • Cytokeratin-23 3 4
  • Keratin-23 3 4
  • CK-23 3 4
  • K23 3 4
  • Hyperacetylation-Inducible Type I Keratin 3
  • Histone Deacetylase Inducible Keratin 23 3
  • Type I Intermediate Filament Cytokeratin 3
  • Keratin, Type I Cytoskeletal 23 3
  • Cytokeratin 23 3
  • HAIK1 3
  • CK23 3

External Ids for KRT23 Gene

Previous GeneCards Identifiers for KRT23 Gene

  • GC17M041254
  • GC17M038987
  • GC17M039452
  • GC17M036332
  • GC17M039078
  • GC17M034873

Summaries for KRT23 Gene

Entrez Gene Summary for KRT23 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for KRT23 Gene

KRT23 (Keratin 23, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT18.

Gene Wiki entry for KRT23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT23 Gene

Genomics for KRT23 Gene

Regulatory Elements for KRT23 Gene

Genomic Location for KRT23 Gene

Start:
40,922,696 bp from pter
End:
40,937,643 bp from pter
Size:
14,948 bases
Orientation:
Minus strand

Genomic View for KRT23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT23 Gene

Proteins for KRT23 Gene

  • Protein details for KRT23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C075-K1C23_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 23
    Protein Accession:
    Q9C075
    Secondary Accessions:
    • A8K084
    • B7Z7J2
    • I3L3Q6
    • Q9NUR6

    Protein attributes for KRT23 Gene

    Size:
    422 amino acids
    Molecular mass:
    48131 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)

    Alternative splice isoforms for KRT23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT23 Gene

Proteomics data for KRT23 Gene at MOPED

Post-translational modifications for KRT23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT23 Gene

Antibody Products

No data available for DME Specific Peptides for KRT23 Gene

Domains for KRT23 Gene

Gene Families for KRT23 Gene

HGNC:
  • IFF1 :Intermediate filaments type I, keratins (acidic)

Suggested Antigen Peptide Sequences for KRT23 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C075

UniProtKB/Swiss-Prot:

K1C23_HUMAN :
  • Q9C075
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT23: view

Function for KRT23 Gene

Gene Ontology (GO) - Molecular Function for KRT23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT23: view

Phenotypes for KRT23 Gene

genes like me logo Genes that share phenotypes with KRT23: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT23

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT23 Gene

Localization for KRT23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT23 Gene COMPARTMENTS Subcellular localization image for KRT23 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT23 Gene

Pathways for KRT23 Gene

SuperPathways for KRT23 Gene

No Data Available

Interacting Proteins for KRT23 Gene

Selected Interacting proteins: Q9C075-K1C23_HUMAN for KRT23 Gene via I2D

Symbol External ID(s) Details
APC
PRKAB1

Gene Ontology (GO) - Biological Process for KRT23 Gene

None

No data available for Pathways by source for KRT23 Gene

Transcripts for KRT23 Gene

Unigene Clusters for KRT23 Gene

Keratin 23 (histone deacetylase inducible):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT23

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT23 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3:

Relevant External Links for KRT23 Gene

GeneLoc Exon Structure for
KRT23
ECgene alternative splicing isoforms for
KRT23

Expression for KRT23 Gene

mRNA expression in normal human tissues for KRT23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT23 Gene

This gene is overexpressed in Minor Salivary Gland (14.5), Skin - Sun Exposed (Lower leg) (11.2), Skin - Not Sun Exposed (Suprapubic) (9.1), and Whole Blood (9.0).

Protein differential expression in normal tissues for KRT23 Gene

This gene is overexpressed in Salivary gland (48.0) and Cervix (8.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT23 Gene

SOURCE GeneReport for Unigene cluster for KRT23 Gene Hs.9029

genes like me logo Genes that share expressions with KRT23: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for KRT23 Gene

Orthologs for KRT23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT23 35
  • 85.54 (n)
  • 80.96 (a)
KRT23 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT23 35
  • 84.76 (n)
  • 80.81 (a)
KRT23 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt23 35
  • 82.66 (n)
  • 79.1 (a)
Krt23 16
Krt23 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRT23 35
  • 99.51 (n)
  • 99.26 (a)
KRT23 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt23 35
  • 82.66 (n)
  • 79.57 (a)
oppossum
(Monodelphis domestica)
Mammalia KRT23 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT23 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRT23 35
  • 60.51 (n)
  • 50.49 (a)
lizard
(Anolis carolinensis)
Reptilia KRT23 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KRT23 36
  • 35 (a)
OneToOne
Species with no ortholog for KRT23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT23 Gene

ENSEMBL:
Gene Tree for KRT23 (if available)
TreeFam:
Gene Tree for KRT23 (if available)

Paralogs for KRT23 Gene

Paralogs for KRT23 Gene

genes like me logo Genes that share paralogs with KRT23: view

Variants for KRT23 Gene

Sequence variations from dbSNP and Humsavar for KRT23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8037 -- 40,925,461(-) CGCCA(C/T)GAACT synonymous-codon, reference
rs9257 - 40,928,252(+) CTGTG(C/T)CTGCA reference, missense
rs730927 -- 40,924,658(-) CTCCC(A/G)TGAAC intron-variant
rs730928 -- 40,924,674(-) TGTAT(C/G)CAGAC intron-variant
rs730929 -- 40,924,669(-) CCAGA(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT23 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495

Relevant External Links for KRT23 Gene

HapMap Linkage Disequilibrium report
KRT23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT23 Gene

Disorders for KRT23 Gene

Relevant External Links for KRT23

Genetic Association Database (GAD)
KRT23
Human Genome Epidemiology (HuGE) Navigator
KRT23

No disorders were found for KRT23 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KRT23 Gene

Publications for KRT23 Gene

  1. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. (PMID: 11135429) Zhang J.-S. … Smith D.I. (Genes Chromosomes Cancer 2001) 2 3 4 23
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 48
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 48
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 48

Products for KRT23 Gene

Sources for KRT23 Gene

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