KRT23 Gene
protein-coding GIFtS : 52
GCID: GC17 M039078
keratin 23 (histone deacetylase inducible)
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Aliasesfor KRT23 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Keratin 23 (Histone Deacetylase Inducible) 1 2 Cytokeratin-233 K231 2 3 Histone Deacetylase Inducible Keratin 232 CK231 2 Hyperacetylation-Inducible Type I Keratin2 HAIK11 2 Keratin, Type I Cytoskeletal 232 CK-232 3 Keratin-233 DKFZP434G0321 Type I Intermediate Filament Cytokeratin2 MGC261581 Cytokeratin-233 Cytokeratin 232 Keratin-233
Export aliases for KRT23 gene to outside databases Previous GC identifers: GC17M041254 GC17M038987 GC17M039452 GC17M036332 GC17M034873
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Summariesfor KRT23 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KRT23 : The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2008) Gene Wiki entry for KRT23
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Genomic Viewsfor KRT23 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KRT23 gene promoter: SRF C/EBPbeta SRF (504 AA) Evi-1 C/EBPalpha YY1 POU2F1 POU2F1a NF-AT1 Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for KRT23 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT23
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2 KRT23 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M039078: view genomic region
(about GC identifiers )
Start:
39,078,948 bp from pter
End:
39,093,886 bp from pter
Size:
14,939 bases
Orientation:
minus strand
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Proteinsfor KRT23 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075 (See
protein sequence )Recommended Name: Keratin, type I cytoskeletal 23 Size : 422 amino acids; 48131 Da
Subunit : Heterotetramer of two type I and two type II keratins (By similarity)
Miscellaneous : There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)
Secondary accessions : A8K084 Q9NUR6Explore the universe of human proteins at neXtProt for KRT23: NX_Q9C075 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9C075 KRT23 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056330.3 ENSEMBL proteins: ENSP00000209718 ENSP00000414056 ENSP00000462335 ENSP00000464548 ENSP00000464051 ENSP00000467393 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005882 intermediate filament
IEA --
KRT23 for ontologies About GeneDecksing KRT23 Antibody Products: Assay Products for KRT23:
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Protein
Domains / Familiesfor KRT23 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KRT23 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9C075 ProtoNet protein and cluster: Q9C075
3 Blocks protein families : IPB001664 Intermediate filament protein IPB002017 Spectrin repeat IPB002957 Type I keratin signature UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075 Similarity : Belongs to the intermediate filament family
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Functionfor KRT23 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRT23 (NM_015515 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT23
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005198 structural molecule activity
IEA --
KRT23 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for KRT23 :
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Pathways & Interactionsfor KRT23 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT23 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for KRT23 (Q9C075 3 ENSP00000209718 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor KRT23 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KRT23 Search CenterWatch for drugs/clinical trials and news about KRT23 / K1C23
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Transcriptsfor KRT23 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KRT23 gene (2 alternative transcripts): NM_015515.3 NM_173213.1 Unigene Cluster for KRT23:
Keratin 23 (histone deacetylase inducible) Hs.9029 [show with all ESTs ] Unigene Representative Sequence: NM_015515 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000209718 (uc002hvm.1 uc002hvn.1 ) ENST00000436344 (uc010wfl.1 )ENST00000462312 (uc010cxf.1 ) ENST00000582754 (uc010cxg.3 ) ENST00000494691 ENST00000584517 ENST00000485751 ENST00000582283 ENST00000585006 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRT23 (NM_015515 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT23
Additional cDNA sequence: AF075083.1 AF102848.1 AK002047.1 AK225866.1 AK289449.1 AK302109.1 AK310880.1 AK314604.1 BC028356.2
13 DOTS entries : DT.95176320 DT.446021
DT.100830363 DT.120920236 DT.120920249 DT.86852611 DT.100830359 DT.95176319 DT.100773211 DT.100830355 DT.120920237 DT.91739504 DT.95176298 24/232 AceView cDNA sequences (see all 232 ):
CR611999 CR618444 AW994770 AI270332 BV177635 CR596166 CR618027 CR608577 BE813692 AU137923 CR602144 AI093066 CR599508 CR624508 CR608150 CA314807 CR595740 CR608727 AA382448 CR590444 CR601789 CR612571 AF075083 CA310718 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT23 About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 SP1 :                         SP2 :       -   -                 SP3 :                        
ECgene alternative splicing isoforms for KRT23
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Expression for KRT23 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KRT23 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGACCAATGA
About this image KRT23 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KRT23 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KRT23 SOURCE GeneReport for Unigene cluster: Hs.9029 SABiosciences Custom PCR Arrays for KRT23 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT23Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KRT23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT23 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23
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Orthologsfor KRT23 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for KRT23 gene from 2/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for KRT23 (if available)TreeFam Gene Tree for KRT23 (if available)
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Paralogsfor KRT23 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KRT23 gene KRT17 2 KRT16 2 KRT18 2 KRT25 2 KRT27 2 KRT20 2 KRT19 2 KRT28 2 KRT14 2 KRT13 2 KRT26 2 KRT10 2 KRT12 2 KRT15 2 KRT24 2 KRT9 2 18/39 SIMAP similar genes for KRT23 using alignment to 5 protein entries: K1C23_HUMAN (see all proteins )
(see all similar genes ):DKFZp434G032 type I hair keratin JUP GUCA1B KRT31 keratin KRT16 K14 KRT33A KRT33B KRT34 KRT15 KRT19 KRT9 KRT13 KRT17 KRT32 KRT20
KRT23 for paralogs About GeneDecksing
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Genomic Variantsfor KRT23 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KRT23 (39078948 - 39093886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KRT23: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT23
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Disorders
/ Diseasesfor KRT23 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KRT23 for disorders About GeneDecksing
OMIM gene information: 606194
OMIM disorders : --6 diseases for KRT23 : About MalaCards aggressive periodontitis periodontitis pulmonary disease colon cancer pancreatic cancer pancreatitis Genetic Association Database (GAD): KRT23 Human Genome Epidemiology (HuGE) Navigator: KRT23 (5 documents) Export disorders for KRT23 gene to outside databases
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Publicationsfor KRT23 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KRT23 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with KRT23) Utopia : connect your pdf to the dynamic world of online information
Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. (PubMed id 11135429) 1 , 2 , 3, 9 Zhang J.-S.... Smith D.I. (2001) New consensus nomenclature for mammalian keratins. (PubMed id 16831889) 1 , 3 Schweizer J....Wright M.W. (2006) Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (PubMed id 15081423) 1 , 4 Suzuki A....Kamoi K. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Keratin 23, a novel DPC4/Smad4 target gene which bind s 14-3-3I/. (PubMed id 21492476) 1 Liffers S.T....Hahn S.A. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168) 1 Guey L.T....Malats N. (2010) Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584) 1 Kim J.J....Lee J.K. (2010) A human MAP kinase interactome. (PubMed id 20936779) 1 Bandyopadhyay S....Ideker T. (2010)
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External Searches for KRT23 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KRT23 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KRT23 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KRT23 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KRT23 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KRT23 gene: Search GeneIP for patents involving KRT23 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KRT23 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KRT23 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KRT23 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT23 OriGene Protein Over-expression Lysate for KRT23 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KRT23 OriGene 3'-UTR Clone for KRT23 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT23 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KRT23 OriGene Custom Protein Services for KRT23 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT23 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT23 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT23 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KRT23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT23
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KRT23 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT23
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Aliases for KRT23
Databases for KRT23
Disorders / Diseases for KRT23
Domains / Families for KRT23
Drugs / Compounds for KRT23
Expression for KRT23
Function for KRT23
Genomic Views for KRT23
Intellectual Property for KRT23
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Paralogs for KRT23
Pathways / Interactions for KRT23
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Summaries for KRT23
Transcripts for KRT23
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