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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT23 Gene

protein-coding   GIFtS: 52
GCID: GC17M039078

keratin 23 (histone deacetylase inducible)

 Explore 6 diseases affiliated with
KRT23 via our new
 Human Malady Compendium 
Biological research products
for KRT23
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Keratin 23 (Histone Deacetylase Inducible)1 2     Cytokeratin-233
K231 2 3     Histone Deacetylase Inducible Keratin 232
CK231 2     Hyperacetylation-Inducible Type I Keratin2
HAIK11 2     Keratin, Type I Cytoskeletal 232
CK-232 3     Keratin-233
DKFZP434G0321     Type I Intermediate Filament Cytokeratin2
MGC261581     Cytokeratin-233
Cytokeratin 232     Keratin-233

External Ids:    HGNC: 64381   Entrez Gene: 259842   Ensembl: ENSG000001082447   OMIM: 6061945   UniProtKB: Q9C0753   

Export aliases for KRT23 gene to outside databases

Previous GC identifers: GC17M041254 GC17M038987 GC17M039452 GC17M036332 GC17M034873


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT23:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins
responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins.
The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type
I cytokeratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2008)

Gene Wiki entry for KRT23


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT23 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   Evi-1   C/EBPalpha   YY1   POU2F1   POU2F1a   NF-AT1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KRT23 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT23 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039078:  view genomic region     (about GC identifiers)

Start:
39,078,948 bp from pter      End:
39,093,886 bp from pter
Size:
14,939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 23  
Size: 422 amino acids; 48131 Da
Subunit: Heterotetramer of two type I and two type II keratins (By similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa)
Secondary accessions: A8K084 Q9NUR6

Explore the universe of human proteins at neXtProt for KRT23: NX_Q9C075

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C075

  • KRT23 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056330.3  
    ENSEMBL proteins: 
     ENSP00000209718   ENSP00000414056   ENSP00000462335   ENSP00000464548   ENSP00000464051  
     ENSP00000467393  

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    OriGene Protein Over-expression Lysate: KRT23
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    Novus Biologicals KRT23 Protein
    Novus Biologicals KRT23 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KRT23

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--


    KRT23 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KRT23


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KRT23 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry Q9C075

    ProtoNet protein and cluster: Q9C075

    3 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002017 Spectrin repeat
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C23_HUMAN, Q9C075
    Similarity: Belongs to the intermediate filament family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: KRT23
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT23 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--


    KRT23 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KRT23:
     Cell division defect  Decreased cell number, increas  Increased number of mitotic ce 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KRT23 (Q9C0753 ENSP000002097184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    PRKAB1Q9Y4783I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT23
    Search CenterWatch for drugs/clinical trials and news about KRT23 / K1C23 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT23 gene (2 alternative transcripts): 
    NM_015515.3  NM_173213.1  

    Unigene Cluster for KRT23:

    Keratin 23 (histone deacetylase inducible)
    Hs.9029  [show with all ESTs]
    Unigene Representative Sequence: NM_015515
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209718(uc002hvm.1 uc002hvn.1) ENST00000436344(uc010wfl.1)
    ENST00000462312(uc010cxf.1) ENST00000582754(uc010cxg.3) ENST00000494691
    ENST00000584517 ENST00000485751 ENST00000582283 ENST00000585006

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT23
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    SwitchGear 3'UTR luciferase reporter plasmidKRT23 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT23 (see all 7)
    OriGene shRNA RFP: KRT23
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    Additional cDNA sequence: 

    AF075083.1 AF102848.1 AK002047.1 AK225866.1 AK289449.1 AK302109.1 AK310880.1 AK314604.1 
    BC028356.2 

    13 DOTS entries:

    DT.95176320  DT.446021  DT.100830363  DT.120920236  DT.120920249  DT.86852611  DT.100830359  DT.95176319 
    DT.100773211  DT.100830355  DT.120920237  DT.91739504  DT.95176298 

    24/232 AceView cDNA sequences (see all 232):

    CR611999 CR618444 AW994770 AI270332 BV177635 CR596166 CR618027 CR608577 
    BE813692 AU137923 CR602144 AI093066 CR599508 CR624508 CR608150 CA314807 
    CR595740 CR608727 AA382448 CR590444 CR601789 CR612571 AF075083 CA310718 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT23    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                    -     -                                             
    SP3:                                                                        


    ECgene alternative splicing isoforms for KRT23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACCAATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KRT23 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    OvaryAntral FollicleCumulus CellsOvary
    KidneyMetanephrosKidney
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See KRT23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT23

    SOURCE GeneReport for Unigene cluster: Hs.9029
        SABiosciences Custom PCR Arrays for KRT23
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT23 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KRT231 keratin 23 (histone deacetylase inducible) 62.64(n)
    53.37(a)
      420044  XM_418167.3  XP_418167.3 
    zebrafish
    (Danio rerio)
    Actinopterygii cyt16
    zgc:1098686
    (see all 15)
    zgc:109868
    (see all 15)
    41(a)
    40(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    19(5986623-5988852)
    19(5974115-5976185)


    ENSEMBL Gene Tree for KRT23 (if available)
    TreeFam Gene Tree for KRT23 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT23 gene
    KRT172  KRT162  KRT182  KRT252  KRT272  KRT202  KRT192  KRT282  
    KRT142  KRT132  KRT262  KRT102  KRT122  KRT152  KRT242  KRT92  
    18/39 SIMAP similar genes for KRT23 using alignment to 5 protein entries:     K1C23_HUMAN (see all proteins) (see all similar genes):
    DKFZp434G032    type I hair keratin    JUP    GUCA1B    KRT31    keratin
    KRT16    K14    KRT33A    KRT33B    KRT34    KRT15
    KRT19    KRT9    KRT13    KRT17    KRT32    KRT20

    KRT23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in KRT23 are shown (see all 386    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs762526981,2
    C--39078588(+) CTTAGA/TGTAGC 1 -- ds50010--------
    rs799646501,2
    C--39078590(+) TAGAGA/TAGCCT 1 -- ds50010--------
    rs1874800191,2
    --39078657(+) GCATAA/CTTTTT 1 -- ds50010--------
    rs1392274711,2
    --39078686(+) GTGAGG/TCTTTC 1 -- ds50010--------
    rs99088001,2
    C,--39078701(+) CCTCCC/TTTTCT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1499853521,2
    --39078771(+) CATGAA/CTCATG 1 -- ds50010--------
    rs22698621,2
    C,F,A,H,--39078825(-) TCACGG/TCAGCC 1 -- ds500126Minor allele frequency- T:0.17EA NS NA WA 4442
    rs1904710681,2
    --39078826(+) GCTGCC/TGTGAA 1 -- ds50010--------
    rs175683111,2
    C,F,H,--39078845(+) ATGTCT/CGGAGA 1 -- ds500115Minor allele frequency- C:0.04NA NS EA WA 2024
    rs22698611,2
    C,F,O,A,H,--39078939(-) TGTCTC/TTTTTT 1 -- ds500137Minor allele frequency- T:0.44EA NA NS WA CSA 4982

    HapMap Linkage Disequilibrium report for KRT23 (39078948 - 39093886 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KRT23: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT23
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KRT23 for disorders           About GeneDecksing

    OMIM gene information: 606194    OMIM disorders: --

    6 diseases for KRT23:    About MalaCards
    aggressive periodontitis    periodontitis    pulmonary disease    colon cancer
    pancreatic cancer    pancreatitis

    Genetic Association Database (GAD): KRT23
    Human Genome Epidemiology (HuGE) Navigator: KRT23 (5 documents)

    Export disorders for KRT23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT23 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with KRT23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. (PubMed id 11135429)1, 2, 3, 9 Zhang J.-S.... Smith D.I. (2001)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    3. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (PubMed id 15081423)1, 4 Suzuki A....Kamoi K. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Keratin 23, a novel DPC4/Smad4 target gene which bind s 14-3-3I/. (PubMed id 21492476)1 Liffers S.T....Hahn S.A. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
    9. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1 Kim J.J....Lee J.K. (2010)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25984 HGNC: 6438 AceView: KRT23 Ensembl:ENSG00000108244 euGenes: HUgn25984
    ECgene: KRT23 H-InvDB: KRT23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT23 gene:
    Search GeneIP for patents involving KRT23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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