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Aliases for KRT222 Gene

Aliases for KRT222 Gene

  • Keratin 222 2 3 5
  • Keratin-222 Pseudogene 3 4
  • Keratin 222, Type II 2 3
  • KRT222P 3 4
  • KA21 3 4
  • Keratin-Like Protein KRT222 3
  • Keratin 222 Pseudogene 2
  • Keratin-222 4

External Ids for KRT222 Gene

Previous HGNC Symbols for KRT222 Gene

  • KRT222P

Previous GeneCards Identifiers for KRT222 Gene

  • GC17M036065
  • GC17M038810
  • GC17M034606

Summaries for KRT222 Gene

GeneCards Summary for KRT222 Gene

KRT222 (Keratin 222) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is ENSG00000264058.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT222 Gene

Genomics for KRT222 Gene

Regulatory Elements for KRT222 Gene

Enhancers for KRT222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G040546 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +108.1 108078 20.3 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 CCR7 THRA TOP2A KRT222 IGFBP4 ENSG00000266088 KRTAP3-2 KRT34 GJD3 CASC3
GH17G039753 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +908.6 908587 7.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF766 ZNF143 GSDMB ORMDL3 THRA IKZF3 KRT222 MED24 STARD3 FBXL20 CDK12 WIPF2
GH17G040595 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +67.3 67255 4.3 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SMARCE1 CCR7 SNORD124 KRT222 KRT28 RARA WIPF2 KRTAP3-2 CASC3 KRTAP2-1
GH17G040601 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +59.5 59544 8.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A GLI4 YBX1 ZNF2 YY1 ZNF121 SMARCE1 CCR7 KRT222 RAPGEFL1 RARA CASC3 KRTAP3-2 WIPF2 ENSG00000279775 GC17M040594
GH17G040442 1.7 FANTOM5 ENCODE dbSUPER 10.5 +220.9 220929 3.9 HDGF FOXA2 PKNOX1 ARNT CREB3L1 AGO1 ZFP64 SIN3A ARID4B ZNF2 MED1 CDK12 THRA TOP2A CCR7 SNORD124 KRT222 RARA ENSG00000266208 RARA-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT222 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT222 Gene

Chromosome:
17
Start:
40,654,665 bp from pter
End:
40,665,181 bp from pter
Size:
10,517 bases
Orientation:
Minus strand

Genomic View for KRT222 Gene

Genes around KRT222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT222 Gene

Proteins for KRT222 Gene

  • Protein details for KRT222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1A0-KT222_HUMAN
    Recommended name:
    Keratin-like protein KRT222
    Protein Accession:
    Q8N1A0
    Secondary Accessions:
    • Q7Z368

    Protein attributes for KRT222 Gene

    Size:
    295 amino acids
    Molecular mass:
    34158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRT222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT222 Gene

Post-translational modifications for KRT222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT222 Gene

No data available for DME Specific Peptides for KRT222 Gene

Domains & Families for KRT222 Gene

Gene Families for KRT222 Gene

Protein Domains for KRT222 Gene

Suggested Antigen Peptide Sequences for KRT222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1A0

UniProtKB/Swiss-Prot:

KT222_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT222: view

Function for KRT222 Gene

Gene Ontology (GO) - Molecular Function for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT222: view

Phenotypes for KRT222 Gene

GenomeRNAi human phenotypes for KRT222:
genes like me logo Genes that share phenotypes with KRT222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT222 Gene

Localization for KRT222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT222 gene
Compartment Confidence
cytoskeleton 3
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT222 Gene

Pathways & Interactions for KRT222 Gene

SuperPathways for KRT222 Gene

No Data Available

Interacting Proteins for KRT222 Gene

Selected Interacting proteins: Q8N1A0-KT222_HUMAN for KRT222 Gene via IID MINT

Symbol External ID(s) Details
KDM1A

Gene Ontology (GO) - Biological Process for KRT222 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRT222 Gene

Drugs & Compounds for KRT222 Gene

No Compound Related Data Available

Transcripts for KRT222 Gene

mRNA/cDNA for KRT222 Gene

Unigene Clusters for KRT222 Gene

Keratin 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT222 Gene

No ASD Table

Relevant External Links for KRT222 Gene

GeneLoc Exon Structure for
KRT222
ECgene alternative splicing isoforms for
KRT222

Expression for KRT222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRT222 Gene

This gene is overexpressed in Skin (46.6) and Urine (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT222 Gene



Protein tissue co-expression partners for KRT222 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT222 Gene:

KRT222

SOURCE GeneReport for Unigene cluster for KRT222 Gene:

Hs.6920

Evidence on tissue expression from TISSUES for KRT222 Gene

  • Adrenal gland(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with KRT222: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT222 Gene

Orthologs for KRT222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
KRT222 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
KRT222 34
  • 93.79 (n)
cow
(Bos Taurus)
Mammalia KRT222 34 35
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krt222 34 16 35
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Krt222 34
  • 85.2 (n)
chicken
(Gallus gallus)
Aves KRT222 34 35
  • 70.73 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia krt222 34
  • 64.71 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-78i5.3 34
  • 59.1 (n)
KRT222 35
  • 27 (a)
OneToMany
Species where no ortholog for KRT222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT222 Gene

ENSEMBL:
Gene Tree for KRT222 (if available)
TreeFam:
Gene Tree for KRT222 (if available)

Paralogs for KRT222 Gene

Paralogs for KRT222 Gene

(1) SIMAP similar genes for KRT222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRT222: view

Variants for KRT222 Gene

Sequence variations from dbSNP and Humsavar for KRT222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000058895 -- 40,658,281(+) AAAGA(C/T)TTTGA intron-variant
rs1000127471 -- 40,656,433(+) TAGAG(A/G)GAATA reference, missense
rs1000849529 -- 40,665,210(+) AAAGA(C/T)GCAGA upstream-variant-2KB
rs1001236584 -- 40,667,118(+) CTCAG(C/T)TTGGA upstream-variant-2KB
rs1001453020 -- 40,666,157(+) TCTCT(C/T)CCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT222 Gene

Variant ID Type Subtype PubMed ID
esv2758689 CNV gain 17122850
nsv1146669 OTHER inversion 26484159
nsv574994 CNV gain 21841781

Variation tolerance for KRT222 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT222 Gene

Disorders for KRT222 Gene

Relevant External Links for KRT222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT222

No disorders were found for KRT222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT222 Gene

Publications for KRT222 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 4 64
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M. … Magin T.M. (Eur. J. Cell Biol. 2004) 3 64

Products for KRT222 Gene

Sources for KRT222 Gene

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