Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT222 Gene

Aliases for KRT222 Gene

  • Keratin 222, Type II 2 3
  • Keratin 222 Pseudogene 2 3
  • Keratin-222 Pseudogene 3 4
  • KRT222P 3 4
  • KA21 3 4
  • Keratin-Like Protein KRT222 3
  • Keratin 222 2
  • Keratin-222 4

External Ids for KRT222 Gene

Previous HGNC Symbols for KRT222 Gene

  • KRT222P

Previous GeneCards Identifiers for KRT222 Gene

  • GC17M036065
  • GC17M038810
  • GC17M034606

Summaries for KRT222 Gene

GeneCards Summary for KRT222 Gene

KRT222 (Keratin 222, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT222 Gene

Genomics for KRT222 Gene

Genomic Location for KRT222 Gene

Start:
40,654,665 bp from pter
End:
40,665,181 bp from pter
Size:
10,517 bases
Orientation:
Minus strand

Genomic View for KRT222 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT222 Gene

No data available for Regulatory Elements for KRT222 Gene

Proteins for KRT222 Gene

  • Protein details for KRT222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1A0-KT222_HUMAN
    Recommended name:
    Keratin-like protein KRT222
    Protein Accession:
    Q8N1A0
    Secondary Accessions:
    • Q7Z368

    Protein attributes for KRT222 Gene

    Size:
    295 amino acids
    Molecular mass:
    34158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRT222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT222 Gene

Proteomics data for KRT222 Gene at MOPED

Post-translational modifications for KRT222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT222 Gene

No data available for DME Specific Peptides for KRT222 Gene

Domains for KRT222 Gene

Protein Domains for KRT222 Gene

Suggested Antigen Peptide Sequences for KRT222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1A0

UniProtKB/Swiss-Prot:

KT222_HUMAN :
  • Q8N1A0
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT222: view

No data available for Gene Families for KRT222 Gene

Function for KRT222 Gene

Gene Ontology (GO) - Molecular Function for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT222: view

Animal Model Products

miRNA for KRT222 Gene

miRTarBase miRNAs that target KRT222

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT222

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT222 Gene

Localization for KRT222 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT222 Gene COMPARTMENTS Subcellular localization image for KRT222 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2
peroxisome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT222 Gene

Pathways for KRT222 Gene

SuperPathways for KRT222 Gene

No Data Available

Interacting Proteins for KRT222 Gene

Gene Ontology (GO) - Biological Process for KRT222 Gene

None

No data available for Pathways by source for KRT222 Gene

Transcripts for KRT222 Gene

mRNA/cDNA for KRT222 Gene

Unigene Clusters for KRT222 Gene

Keratin 222:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT222

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT222 Gene

No ASD Table

Relevant External Links for KRT222 Gene

GeneLoc Exon Structure for
KRT222
ECgene alternative splicing isoforms for
KRT222

Expression for KRT222 Gene

mRNA expression in normal human tissues for KRT222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KRT222 Gene

This gene is overexpressed in Skin (46.6) and Urine (15.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT222 Gene

SOURCE GeneReport for Unigene cluster for KRT222 Gene Hs.6920

genes like me logo Genes that share expressions with KRT222: view

Expression partners for KRT222 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRT222 Gene

Orthologs for KRT222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT222 35
  • 93.56 (n)
  • 94.58 (a)
KRT222 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KRT222 35
  • 93.79 (n)
  • 95.25 (a)
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krt222 35
  • 85.94 (n)
  • 88.78 (a)
Krt222 16
Krt222 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRT222 35
  • 99.66 (n)
  • 99.66 (a)
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Krt222 35
  • 85.2 (n)
  • 87.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRT222 35
  • 70.73 (n)
  • 67.38 (a)
KRT222 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia krt222 35
  • 64.71 (n)
  • 56.75 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-78i5.3 35
  • 59.1 (n)
  • 56.72 (a)
KRT222 36
  • 27 (a)
OneToMany
Species with no ortholog for KRT222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT222 Gene

ENSEMBL:
Gene Tree for KRT222 (if available)
TreeFam:
Gene Tree for KRT222 (if available)

Paralogs for KRT222 Gene

Selected SIMAP similar genes for KRT222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRT222: view

No data available for Paralogs for KRT222 Gene

Variants for KRT222 Gene

Sequence variations from dbSNP and Humsavar for KRT222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs917593 -- 40,660,274(+) TTGCA(A/G)TATCT intron-variant
rs917595 -- 40,663,246(+) AAGAA(C/G)TCTAT intron-variant
rs2008469 -- 40,660,343(+) TGCCA(C/T)GATCT intron-variant
rs4643384 -- 40,667,076(+) actgt(C/T)tttga upstream-variant-2KB
rs4890119 -- 40,661,369(+) TCAAG(C/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT222 Gene

Variant ID Type Subtype PubMed ID
dgv960e1 CNV Complex 17122850
nsv908225 CNV Loss 21882294

Relevant External Links for KRT222 Gene

HapMap Linkage Disequilibrium report
KRT222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT222 Gene

Disorders for KRT222 Gene

No disorders were found for KRT222 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRT222 Gene

Publications for KRT222 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 4
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRT222 Gene

Sources for KRT222 Gene

Back to Top

Content