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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT222 Gene

protein-coding GIFtS: 39
GCID: GC17M038810

keratin 222

(Previous name: keratin 222 pseudogene )
(Previous symbol: KRT222P)

Search for KRT222
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 222¹ ²		Keratin-222 Pseudogene² ³
KA21¹ ² ³		MGC45562¹
KRT222P¹ ² ³		Keratin-Like Protein KRT222²
Keratin 222 Pseudogene¹ ²		Keratin-222³

External Ids:	HGNC: 28695¹	Entrez Gene: 125113²	Ensembl: ENSG00000213424⁷	UniProtKB: Q8N1A0³

Export aliases for KRT222 gene to outside databases

Previous GC identifers: GC17M036065 GC17M034606

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for KRT222
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT222 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT222

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT222

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2

KRT222 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT222 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M038810: view genomic region (about GC identifiers)

Start:	38,810,917 bp from pter	End:	38,821,433 bp from pter
Size:	10,517 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KT222_HUMAN, Q8N1A0 (See protein sequence)

Recommended Name: Keratin-like protein KRT222

Size: 295 amino acids; 34158 Da

Caution: According to PubMed:16831889, it is a pseudogene

Secondary accessions: Q7Z368

Alternative splicing: 2 isoforms: Q8N1A0-1 Q8N1A0-2

Explore the universe of human proteins at neXtProt for KRT222: NX_Q8N1A0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N1A0

KRT222 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689562.1

ENSEMBL proteins:

ENSP00000377613 ENSP00000377616 ENSP00000463865 ENSP00000464647

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005882	intermediate filament	IEA	--

KRT222 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT222 for domains About GeneDecksing

4 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR016044 F

Graphical View of Domain Structure for InterPro Entry Q8N1A0

ProtoNet protein and cluster: Q8N1A0

UniProtKB/Swiss-Prot: KT222_HUMAN, Q8N1A0

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--

KRT222 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KRT222

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT222
Search CenterWatch for drugs/clinical trials and news about KRT222 / KT222

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KRT222 gene:

NM_152349.2

Unigene Cluster for KRT222:

Keratin 222

Hs.6920 [show with all ESTs]

Unigene Representative Sequence: NM_152349

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394049(uc002hvb.2 uc002hvc.2) ENST00000394052 ENST00000581564(uc010cxc.3)

ENST00000580719

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Additional cDNA sequence:

AK308598.1 BC032815.1 BX538083.1

4 DOTS entries:

DT.95259944 DT.208369 DT.100890768 DT.120996230

24/568 AceView cDNA sequences (see all 568):

CD656329 AK092967 AI493610 BM760512 AU132352 BF378340 AI932909 BM474370

N35385 BU742428 BE857142 CA844318 CR626250 AW516117 AI377071 CK299411

BM766141 AA385956 BU630842 CR595985 BQ189244 AI298193 BP353945 BM695900

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT222 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTATTCCC

About this image

KRT222 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KRT222 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT222

SOURCE GeneReport for Unigene cluster: Hs.6920

SABiosciences Custom PCR Arrays for KRT222

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KRT222¹	keratin 222	70.85(n) 67.38(a)		420046 NM_001195477.1 NP_001182406.1
lizard (Anolis carolinensis)	Reptilia	KRT222⁶	--	68(a)	1 → many	6(70363393-70386111)
zebrafish (Danio rerio)	Actinopterygii	si:ch73-78i5.3¹	si:ch73-78i5.3	58.93(n) 56.96(a)		100003752 XM_001343189.3 XP_001343225.3

ENSEMBL Gene Tree for KRT222 (if available)
TreeFam Gene Tree for KRT222 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT222 gene

KRT34² KRT31² ENSG00000264058² KRT35² KRT39² KRT40² BFSP2² KRT37²

KRT32² KRT38² KRT36² KRT33B² KRT33A²

1 SIMAP similar gene for KRT222 using alignment to 2 protein entries: KT222_HUMAN (see all proteins):

KRT5

KRT222 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73295333^1,2	C,	--	38811645(+)	`TTGAAC/TGATTT`	1	--	ds500¹		2		WA	120
rs79377848^1,2	C,F,	--	38811958(+)	`TCTTCC/TGGAAA`	1	--	ut3¹		1		WA	118
rs191211693^1,2		--	38812030(+)	`CTCAAA/GTTAGC`	1	--	ut3¹		0	--	--	--	--
rs17636704^1,2	C,F,H,	--	38812046(+)	`GGTGTG/ATTCTA`	1	--	ut3¹		8		NA NS	668
rs180847482^1,2		--	38812202(+)	`AAACAC/TTGTAG`	1	--	ut3¹		0	--	--	--	--
rs112265868^1,2	C,	--	38812232(+)	`AATGGC/TGAATA`	1	--	ut3¹		1		CSA	2
rs185783655^1,2		--	38812256(+)	`CTTAAC/TACAAT`	1	--	ut3¹		0	--	--	--	--
rs140553864^1,2	C,	--	38812451(+)	`CATTC-/ATATATA`	1	--	ut3¹		0	--	--	--	--
rs191029390^1,2		--	38812529(+)	`GAGAAC/TCACAT`	1	--	ut3¹		0	--	--	--	--
rs182844934^1,2	C,	--	38812788(+)	`AAGATA/CAAATC`	2	D Y	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KRT222 (38810917 - 38821433 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KRT222
1 CNV: 4035

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRT222 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT222)

Utopia: connect your pdf to the dynamic
world of online information

New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 2, 3} Schweizer J....Wright M.W. (2006)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Comprehensive analysis of keratin gene clusters in humans and rodents. (PubMed id 15085952)¹ Hesse M.... Magin T.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 125113	HGNC: 28695	AceView: SMARCE1andMGC45562	Ensembl:ENSG00000213424	euGenes: HUgn125113
ECgene: KRT222	H-InvDB: KRT222

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT222	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KRT222 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KRT222 gene:
Search GeneIP for patents involving KRT222

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT222

	SwitchGear 3'UTR luciferase reporter plasmids for KRT222
	SwitchGear Promoter luciferase reporter plasmids for KRT222

Search ThermoFisher Antibodies for KRT222

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT222

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KRT222 gene at Home site.

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KRT222 Gene

keratin 222

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KRT222 Gene

keratin 222

Aliasesfor KRT222 gene

Summariesfor KRT222 gene

Genomic Viewsfor KRT222 gene

Proteinsfor KRT222 gene

Protein Domains /Familiesfor KRT222 gene

Functionfor KRT222 gene

Pathways & Interactionsfor KRT222 gene

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Expression for KRT222 gene

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Genome Databases showing KRT222 gene

Other Databases showing KRT222 gene

Specialized Databases showing KRT222 gene

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Aliases
for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene

Function
for KRT222 gene

Pathways & Interactions
for KRT222 gene

Drugs & Compounds
for KRT222 gene

Transcripts
for KRT222 gene

Expression
for KRT222 gene

Orthologs
for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene

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for KRT222 gene