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Aliases for KRT222 Gene

Aliases for KRT222 Gene

  • Keratin 222 2 3 5
  • Keratin-222 Pseudogene 3 4
  • Keratin 222, Type II 2 3
  • Keratin-222 3 4
  • KRT222P 3 4
  • KA21 3 4
  • Keratin-Like Protein KRT222 3
  • Keratin 222 Pseudogene 2

External Ids for KRT222 Gene

Previous HGNC Symbols for KRT222 Gene

  • KRT222P

Previous GeneCards Identifiers for KRT222 Gene

  • GC17M036065
  • GC17M038810
  • GC17M034606

Summaries for KRT222 Gene

GeneCards Summary for KRT222 Gene

KRT222 (Keratin 222) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is ENSG00000264058.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT222 Gene

Genomics for KRT222 Gene

Regulatory Elements for KRT222 Gene

Enhancers for KRT222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KRT222 on UCSC Golden Path with GeneCards custom track

Promoters for KRT222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KRT222 Gene

40,654,665 bp from pter
40,665,181 bp from pter
10,517 bases
Minus strand

Genomic View for KRT222 Gene

Genes around KRT222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT222 Gene

Proteins for KRT222 Gene

  • Protein details for KRT222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-like protein KRT222
    Protein Accession:
    Secondary Accessions:
    • Q7Z368

    Protein attributes for KRT222 Gene

    295 amino acids
    Molecular mass:
    34158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRT222 Gene


neXtProt entry for KRT222 Gene

Post-translational modifications for KRT222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT222 Gene

No data available for DME Specific Peptides for KRT222 Gene

Domains & Families for KRT222 Gene

Gene Families for KRT222 Gene

Protein Domains for KRT222 Gene

Suggested Antigen Peptide Sequences for KRT222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT222: view

Function for KRT222 Gene

Gene Ontology (GO) - Molecular Function for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT222: view

Phenotypes for KRT222 Gene

GenomeRNAi human phenotypes for KRT222:
genes like me logo Genes that share phenotypes with KRT222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT222 Gene

Localization for KRT222 Gene

Subcellular locations from

Jensen Localization Image for KRT222 Gene COMPARTMENTS Subcellular localization image for KRT222 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT222 Gene

Pathways & Interactions for KRT222 Gene

SuperPathways for KRT222 Gene

No Data Available

Interacting Proteins for KRT222 Gene

Selected Interacting proteins: Q8N1A0-KT222_HUMAN for KRT222 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KRT222 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT222 Gene

Drugs & Compounds for KRT222 Gene

No Compound Related Data Available

Transcripts for KRT222 Gene

mRNA/cDNA for KRT222 Gene

Unigene Clusters for KRT222 Gene

Keratin 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT222 Gene

No ASD Table

Relevant External Links for KRT222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT222 Gene

mRNA expression in normal human tissues for KRT222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRT222 Gene

This gene is overexpressed in Skin (46.6) and Urine (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT222 Gene

Protein tissue co-expression partners for KRT222 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT222 Gene:


SOURCE GeneReport for Unigene cluster for KRT222 Gene:

genes like me logo Genes that share expression patterns with KRT222: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRT222 Gene

Orthologs for KRT222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT222 34
  • 93.56 (n)
  • 94.58 (a)
KRT222 35
  • 95 (a)
(Canis familiaris)
Mammalia KRT222 34
  • 93.79 (n)
  • 95.25 (a)
-- 35
  • 95 (a)
(Mus musculus)
Mammalia Krt222 34
  • 85.94 (n)
  • 88.78 (a)
Krt222 16
Krt222 35
  • 88 (a)
(Pan troglodytes)
Mammalia KRT222 34
  • 99.66 (n)
  • 99.66 (a)
-- 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Krt222 34
  • 85.2 (n)
  • 87.46 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
(Gallus gallus)
Aves KRT222 34
  • 70.73 (n)
  • 67.38 (a)
KRT222 35
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt222 34
  • 64.71 (n)
  • 56.75 (a)
(Danio rerio)
Actinopterygii si:ch73-78i5.3 34
  • 59.1 (n)
  • 56.72 (a)
KRT222 35
  • 27 (a)
Species where no ortholog for KRT222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT222 Gene

Gene Tree for KRT222 (if available)
Gene Tree for KRT222 (if available)

Paralogs for KRT222 Gene

Paralogs for KRT222 Gene

(1) SIMAP similar genes for KRT222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRT222: view

Variants for KRT222 Gene

Sequence variations from dbSNP and Humsavar for KRT222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs917593 -- 40,660,274(+) TTGCA(A/G)TATCT intron-variant
rs917595 -- 40,663,246(+) AAGAA(C/G)TCTAT intron-variant
rs2008469 -- 40,660,343(+) TGCCA(C/T)GATCT intron-variant
rs4643384 -- 40,667,076(+) actgt(C/T)tttga upstream-variant-2KB
rs7207870 -- 40,660,091(+) TCGAT(A/G)CCGCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KRT222 Gene

Variant ID Type Subtype PubMed ID
esv2758689 CNV gain 17122850
nsv1146669 OTHER inversion 26484159
nsv574994 CNV gain 21841781

Variation tolerance for KRT222 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT222 Gene

Disorders for KRT222 Gene

Relevant External Links for KRT222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT222 Gene

Publications for KRT222 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 4 65
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 65
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  5. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M. … Magin T.M. (Eur. J. Cell Biol. 2004) 3 65

Products for KRT222 Gene

Sources for KRT222 Gene

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