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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT222 Gene

protein-coding   GIFtS: 39
GCID: GC17M038810

Keratin 222

(Previous name: keratin 222 pseudogene)
(Previous symbol: KRT222P)
  Search for KRT222
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 2221 2     KA212 3
KRT222P1 2 3     Keratin-Like Protein KRT2222
Keratin 222 Pseudogene1 2     Keratin-2223
Keratin-222 Pseudogene2 3     

External Ids:    HGNC: 286951   Entrez Gene: 1251132   Ensembl: ENSG000002134247   UniProtKB: Q8N1A03   

Export aliases for KRT222 gene to outside databases

Previous GC identifers: GC17M036065 GC17M034606


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KRT222 Gene: 
KRT222 (keratin 222) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is ENSG00000264058.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KRT222
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT222 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT222

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT222


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT222 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT222 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038810:  view genomic region     (about GC identifiers)

Start:
38,810,917 bp from pter      End:
38,821,433 bp from pter
Size:
10,517 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KT222_HUMAN, Q8N1A0 (See protein sequence)
Recommended Name: Keratin-like protein KRT222  
Size: 295 amino acids; 34158 Da
Caution: According to PubMed:16831889, it is a pseudogene
Secondary accessions: Q7Z368
Alternative splicing: 2 isoforms:  Q8N1A0-1   Q8N1A0-2   

Explore the universe of human proteins at neXtProt for KRT222: NX_Q8N1A0

Explore proteomics data for KRT222 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1A0

  • KRT222 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT222 Protein Expression
    REFSEQ proteins: NP_689562.1  
    ENSEMBL proteins: 
     ENSP00000377613   ENSP00000377616   ENSP00000463865   ENSP00000464647  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--

    KRT222 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry Q8N1A0

    ProtoNet protein and cluster: Q8N1A0

    UniProtKB/Swiss-Prot: KT222_HUMAN, Q8N1A0
    Similarity: Belongs to the intermediate filament family


    KRT222 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT222 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT222

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT222 (KT222)

    Search CenterWatch for drugs/clinical trials and news about KRT222 / KT222

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for KRT222 gene: 
    NM_152349.2  

    Unigene Cluster for KRT222:

    Keratin 222
    Hs.6920  [show with all ESTs]
    Unigene Representative Sequence: NM_152349
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394049(uc002hvb.2 uc002hvc.2) ENST00000394052 ENST00000581564(uc010cxc.3)
    ENST00000580719
    miRNA
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    hsa-miR-9 hsa-miR-616* hsa-miR-373*
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    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AK308598.1 BC032815.1 BX538083.1 

    4 DOTS entries:

    DT.95259944  DT.208369  DT.100890768  DT.120996230 

    24/568 AceView cDNA sequences (see all 568):

    BP353920 BQ670322 BF222773 BQ959759 BP369243 BM799988 BM853442 AI796145 
    BC069196 CF125768 BU684125 AU139031 AI379005 CR598259 AA699598 AK095047 
    BM718791 BC047731 AA278358 BM476843 AA369659 AU138848 AV718137 BM471095 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT222 expression in normal human tissues (normalized intensities)      KRT222 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTATTCCC
    KRT222 Expression
    About this image


    KRT222 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier

    See KRT222 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT222

    SOURCE GeneReport for Unigene cluster: Hs.6920
        SABiosciences Custom PCR Arrays for KRT222
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT222

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT222 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt2221 , 5 keratin 2221, 5 85.94(n)1
    88.78(a)1
      11 (62.92 cM)5
    2684811  NM_172946.21  NP_766534.11 
     992327615 
    chicken
    (Gallus gallus)
    Aves KRT2221 keratin 222 70.85(n)
    67.38(a)
      420046  NM_001195477.1  NP_001182406.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    6(70359764-70386239)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-78i5.31 si:ch73-78i5.3 58.93(n)
    56.96(a)
      100003752  XM_001343189.3  XP_001343225.3 


    ENSEMBL Gene Tree for KRT222 (if available)
    TreeFam Gene Tree for KRT222 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT222 gene
    ENSG000002640582  
    1 SIMAP similar gene for KRT222 using alignment to 2 protein entries:     KT222_HUMAN (see all proteins):
    KRT5

    KRT222 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 SNPs in KRT222 are shown (see all 201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732953331,2
    C,F--38811645(+) TTGAAC/TGATTT 1 -- ds50012Minor allele frequency- T:0.08WA 120
    rs793778481,2
    C,F--38811958(+) TCTTCC/TGGAAA 1 -- ut311Minor allele frequency- T:0.04WA 118
    rs1912116931,2
    C--38812030(+) CTCAAA/GTTAGC 1 -- ut310--------
    rs176367041,2
    C,F,H--38812046(+) GGTGTG/ATTCTA 1 -- ut318Minor allele frequency- A:0.02NA NS 668
    rs1808474821,2
    --38812202(+) AAACAC/TTGTAG 1 -- ut310--------
    rs1122658681,2
    C,F--38812232(+) AATGGC/TGAATA 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1857836551,2
    --38812256(+) CTTAAC/TACAAT 1 -- ut310--------
    rs1405538641,2
    C--38812451(+) CATTC-/ATATATA 1 -- ut310--------
    rs3733548031,2
    C--38812452(+) TCATT-/ATTATAT 1 -- ut310--------
    rs1910293901,2
    --38812529(+) GAGAAC/TCACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT222 (38810917 - 38821433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT222:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908225CNV Loss21882294
    dgv960e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT222 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KRT222)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 2, 3 Schweizer J....Wright M.W. (2006)
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Comprehensive analysis of keratin gene clusters in humans and rodents. (PubMed id 15085952)1 Hesse M.... Magin T.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 125113 HGNC: 28695 AceView: SMARCE1andMGC45562 Ensembl:ENSG00000213424 euGenes: HUgn125113
    ECgene: KRT222 H-InvDB: KRT222

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT222 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT222 gene:
    Search GeneIP for patents involving KRT222

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for KRT222
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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