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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT20 Gene

protein-coding GIFtS: 55
GCID: GC17M039030

keratin 20

Explore 121 diseases affiliated with
KRT20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 20¹ ²		MGC35423¹
K20¹ ² ³		Cytokeratin 20²
CK20¹ ²		Cytokeratin-20³
Protein IT² ³		Keratin, Type I Cytoskeletal 20²
CK-20² ³		Keratin-20³
CD20² ⁵		Cytokeratin-20³
KRT21² ⁵		Keratin-20³

External Ids:	HGNC: 20412¹	Entrez Gene: 54474²	Ensembl: ENSG00000171431⁷	OMIM: 608218⁵	UniProtKB: P35900³

Export aliases for KRT20 gene to outside databases

Previous GC identifers: GC17M038532 GC17M041208 GC17M038940 GC17M039405 GC17M036285 GC17M034826

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT20:

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins

responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins.

The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This

cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the

gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900

Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When

phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)

Gene Wiki entry for KRT20 (Keratin 20)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT20 gene promoter:
POU6F1 (c2) Nkx2-5 NF-AT AREB6 PPAR-gamma1 NF-AT4 NF-AT2 NF-AT3 PPAR-gamma2 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT20 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2

KRT20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT20 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M039030: view genomic region (about GC identifiers)

Start:	39,032,141 bp from pter	End:	39,041,495 bp from pter
Size:	9,355 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900 (See protein sequence)

Recommended Name: Keratin, type I cytoskeletal 20

Size: 424 amino acids; 48487 Da

Subunit: Heterotetramer of two type I and two type II keratins. Associates with KRT8

Subcellular location: Cytoplasm

Developmental stage: First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the

developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of

villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as

well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to

basic; 56-70 kDa)

Secondary accessions: B2R6W7

Explore the universe of human proteins at neXtProt for KRT20: NX_P35900

Post-translational modifications:

Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later

stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity)¹

Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35900

KRT20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061883.1

ENSEMBL proteins:

ENSP00000167588

Human Recombinant Protein Products:

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	Novus Biologicals KRT20 Protein Novus Biologicals KRT20 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for KRT20
	Uscn Proteins for KRT20

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10973561
GO:0005794	Golgi apparatus	--	--
GO:0005882	intermediate filament	NAS	8359595

KRT20 for ontologies About GeneDecksing

KRT20 Antibody Products:

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Assay Products for KRT20:

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	Uscn ELISAs and CLIAs for KRT20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT20 for domains About GeneDecksing

4 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR016044 F

Graphical View of Domain Structure for InterPro Entry P35900

ProtoNet protein and cluster: P35900

2 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900

Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When

phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: KRT20 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT20
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT20:
		hsa-miR-873 hsa-miR-876-5p hsa-miR-3921 hsa-miR-3167
		SwitchGear 3'UTR luciferase reporter plasmid: KRT20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT20 (see all 7) OriGene shRNA RFP: KRT20 OriGene siRNA: KRT20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KRT20

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT20 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT20 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KRT20
		Search LifeMap BioReagents cell lines for KRT20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT20

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005200	structural constituent of cytoskeleton	NAS	8359595
GO:0005515	protein binding	IPI	16608857

KRT20 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KRT20

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/28 Interacting proteins for KRT20 (P35900^{2, 3} ENSP00000167588⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-66419 I2D: score=5 STRING: ENSP00000311695
EIF4E2	O60573²^,³, ENSP00000258416⁴	MINT-67266 I2D: score=5 STRING: ENSP00000258416
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-68279 I2D: score=5 STRING: ENSP00000250113
KRT15	P19012²^,³, ENSP00000254043⁴	MINT-66861 I2D: score=5 STRING: ENSP00000254043
PRC1	O43663²^,³, ENSP00000377793⁴	MINT-67132 I2D: score=5 STRING: ENSP00000377793

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0033554	cellular response to stress	IEA	--
GO:0045109	intermediate filament organization	IMP	12857878
GO:0050708	regulation of protein secretion	IEA	--

KRT20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KRT20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT20
10/17 Novoseek chemical compound relationships for KRT20 gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mucicarmine	78.6	7	11106075 (1), 9208972 (1), 9870855 (1), 19132778 (1) (see all 6)
paraffin	53.9	21	10976695 (1), 10093825 (1), 11668468 (1), 10705819 (1) (see all 15)
estrogen	50.7	57	11028811 (2), 12715337 (2), 9160304 (2), 12217766 (1) (see all 49)
progesterone	50	45	9160304 (2), 12217766 (1), 14506675 (1), 15086841 (1) (see all 39)
hematoxylin	47.5	9	12189500 (1), 10926813 (1), 15589579 (1), 15363204 (1) (see all 7)
b 723	40.5	5	11106075 (2), 15589579 (1), 12481020 (1), 12647218 (1)
ribonucleic acid	1.42	2	9817302 (1), 12498994 (1)
tyrosine	1.03	1	16547650 (1)
sucrose	0	3	17378731 (1)
iron	0	2	16243134 (1), 18603673 (1)

Search CenterWatch for drugs/clinical trials and news about KRT20 / K1C20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRT20 gene:

NM_019010.2

Unigene Cluster for KRT20:

Keratin 20

Hs.84905 [show with all ESTs]

Unigene Representative Sequence: BC031559

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000167588(uc002hvl.3) ENST00000482529

miRNA Products:		OriGene 3'-UTR Clone: KRT20 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT20
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT20:
		hsa-miR-873 hsa-miR-876-5p hsa-miR-3921 hsa-miR-3167
		SwitchGear 3'UTR luciferase reporter plasmid: KRT20 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: KRT20 (NM_019010)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT20

Additional cDNA sequence:

AK312744.1 BC031559.1 X73502.1

4 DOTS entries:

DT.211402 DT.95162475 DT.120986558 DT.91829085

24/60 AceView cDNA sequences (see all 60):

BC031559 BX098834 NM_019010 AA522447 BQ326166 AI821179 AA471027 X73502

BQ316026 BG386855 BQ317223 AW842995 BI762117 AI732166 AA133469 AI732381

BQ316025 BI762148 T29686 BG875568 AW853840 BQ326177 BQ319047 AA327537

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATTGCAA

About this image

KRT20 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primordial Follicle

Pre-Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KRT20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT20

SOURCE GeneReport for Unigene cluster: Hs.84905

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900

Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa.

Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the

gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa

SABiosciences Custom PCR Arrays for KRT20

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KRT20 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KRT20¹	keratin 20	63.59(n) 57.45(a)		420045 XM_418168.3 XP_418168.2
African clawed frog (Xenopus laevis)	Amphibia	M11032.1²	--	73.21(n)		M11032.1
zebrafish (Danio rerio)	Actinopterygii	zgc:109868⁶ zgc:92061⁶ (see all 15)	zgc:92061 (see all 15)	48(a) 48(a) (see all 15)	many ↔ many many ↔ many (see all 15)	19(5974115-5976185) 22(11866190-11869256)

ENSEMBL Gene Tree for KRT20 (if available)
TreeFam Gene Tree for KRT20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT20 gene

KRT17² KRT13² KRT16² KRT26² KRT10² KRT12² KRT18² KRT25²

KRT15² KRT27² KRT24² KRT19² KRT9² KRT28² KRT14² KRT23²

18/39 SIMAP similar genes for KRT20 using alignment to 1 protein entry: K1C20_HUMAN(see all similar genes):

JUP KRT19 KRT13 KRT14 KRT31 KRT33A

KRT33B KRT34 KRT32 KRT15 KRT16 keratin

KRT40 KRT35 KRT17 KRT37 KRTHA7 KRT9

KRT20 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8067614^1,2	C,F,H,	--	34826501(+)	`AATTGG/ACTCAA`	1	--	ut3¹		5	NS EA WA	538
rs8077284^1,2	C,F,H,	--	34826718(+)	`AGTAAT/CGATGT`	1	--	ut3¹ ese³		4	NS EA	420
rs926^1,2	F	--	34826820(-)	`AATCCT/CATTTA`	1	--	ut3¹ ese³		1	MN	184
rs75091657^1,2	F,	--	34826828(+)	`ATTCCC/TGCCAC`	1	--	ut3¹		1	NA	120
rs111603820^1,2	F	--	34827338(+)	`TTCAGG/AATGTC`	1	--	int¹		1	CSA	4
rs74471184^1,2	C,	--	34827446(+)	`ACAAGA/GTTTTT`	1	--	int¹		2	CSA WA	120
rs80013553^1,2	F,	--	34827582(+)	`TAAAAG/AGTGAT`	1	--	int¹		1	WA	118
rs2107215^1,2	C,F,A,H,	--	34827610(-)	`TCCATG/CAGAGA`	1	--	int¹ trp³		8	NS EA WA NA	662
rs74597601^1,2	C,F,	--	34827624(+)	`ATTAAT/CGTGGT`	1	--	int¹		1	NA	120
rs7221531^1,2	C,F,A,	--	34827751(+)	`gatgaC/Tacagc`	1	--	int¹		1	WA	118

HapMap Linkage Disequilibrium report for KRT20 (39032141 - 39041495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT20: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT20

DNA2.0 Custom Variant and Variant Library Synthesis for KRT20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT20 for disorders           About GeneDecksing

OMIM gene information: 608218    OMIM disorders: --

20/121 diseases for KRT20 (see all 121):    About MalaCards

seminal vesicle adenocarcinoma spinal cord injury signet ring cell adenocarcinoma dermoid cyst

pseudomyxoma peritonei ovarian large-cell neuroendocrine carcinoma infiltrative basal cell carcinoma sweat gland carcinoma

dermoid cyst of ovary bile duct adenoma ampulla of vater adenocarcinoma barrett's esophagus

pancreatic mucinous cystadenoma carcinoma papillary serous adenocarcinoma inverted papilloma

chromophobe renal cell carcinoma ovarian mucinous neoplasm ovarian brenner tumor horseshoe kidney

13 diseases from the University of Copenhagen DISEASES database for KRT20:

Carcinoma Merkel cell carcinoma Colorectal cancer Pseudomyxoma peritonei

Cholangiocarcinoma Urinary bladder cancer Vulval Paget's disease Dermoid cyst

Malignant syringoma Adenoma Basal cell carcinoma Ovarian Brenner tumor

Inverted papilloma

10/94 Novoseek disease relationships for KRT20 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma merkel cell	90.5	58	11175640 (5), 10027519 (4), 10728812 (4), 10976695 (2) (see all 29)
carcinoma mucinous	81.7	20	12352188 (2), 14645698 (1), 14668551 (1), 15362373 (1) (see all 13)
adenocarcinoma	81.6	279	15371952 (5), 11745209 (5), 15333652 (5), 18156982 (4) (see all 99)
carcinoma	79.7	167	1371204 (5), 11341356 (4), 11419977 (3), 11488072 (3) (see all 99)
metastatic carcinoma	79.2	25	12172048 (3), 9822920 (2), 9067104 (2), 14668551 (1) (see all 20)
carcinoma neuroendocrine	79.2	16	20182342 (2), 15010880 (2), 10937047 (1), 16508780 (1) (see all 12)
metastasis	76.1	152	11419977 (6), 16980943 (5), 17890913 (5), 17058136 (4) (see all 79)
tumors	74.4	490	16980943 (7), 15245962 (7), 11301341 (7), 11144928 (6) (see all 99)
extramammary pagets disease	73	5	9989849 (2), 10777264 (1)
carcinoma transitional cell	71.2	23	9817302 (2), 11490230 (2), 9067104 (2), 11693559 (2) (see all 16)

Human Genome Epidemiology (HuGE) Navigator: KRT20 (2 documents)

Export disorders for KRT20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KRT20 gene, integrated from 9 sources (see all 844):
(articles sorted by number of sources associating them with KRT20)

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The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PubMed id 8359595)^{1, 2, 3, 9} Moll R.... Franke W.W. (1993)
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PubMed id 12857878)^{1, 2, 9} Zhou Q....Omary M.B. (2003)
[Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients] (PubMed id 12515621)^{1, 3, 9} Ye X....Chen T. (2002)
An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PubMed id 10973561)^{1, 2, 9} Barrett A.W.... Berkovitz B.K.B. (2000)
New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 3} Schweizer J....Wright M.W. (2006)
Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker. (PubMed id 16608857)^{1, 2} Zhou Q.... Omary M.B. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation. (PubMed id 7689500)^{1, 2} Calnek D. and Quaroni A. (1993)
Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. (PubMed id 1696264)^{1, 2} Moll R.... Franke W.W. (1990)
Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases. (PubMed id 18813128)^{1, 9} He H....Chu P.G. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54474	HGNC: 20412	AceView: KRT20	Ensembl:ENSG00000171431	euGenes: HUgn54474
ECgene: KRT20	H-InvDB: KRT20

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT20	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KRT20 gene
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keratin 20

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colon cancer metastatic
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KRT20 Gene

keratin 20

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