Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT20 Gene

Aliases for KRT20 Gene

  • Keratin 20 2 3 5
  • Keratin 20, Type I 2 3
  • Protein IT 3 4
  • CK-20 3 4
  • K20 3 4
  • Keratin, Type I Cytoskeletal 20 3
  • Cytokeratin 20 3
  • Cytokeratin-20 4
  • Keratin-20 4
  • KRT21 3
  • CK20 3
  • CD20 3

External Ids for KRT20 Gene

Previous GeneCards Identifiers for KRT20 Gene

  • GC17M038532
  • GC17M041208
  • GC17M038940
  • GC17M039405
  • GC17M036285
  • GC17M039030
  • GC17M034826

Summaries for KRT20 Gene

Entrez Gene Summary for KRT20 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT20 Gene

KRT20 (Keratin 20) is a Protein Coding gene. Diseases associated with KRT20 include Merkel Cell Carcinoma and Ovarian Brenner Tumor. Among its related pathways are Cytoskeletal Signaling and Developmental Biology. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT14.

UniProtKB/Swiss-Prot for KRT20 Gene

  • Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Gene Wiki entry for KRT20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT20 Gene

Genomics for KRT20 Gene

Regulatory Elements for KRT20 Gene

Enhancers for KRT20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040857 1.3 Ensembl ENCODE 11.2 +27.6 27559 0.2 GTF2E2 ZNF175 BACH1 PTRF RELA DIDO1 ZNF766 GATA2 ZNF584 ZNF639 TMEM99 KRT20 CDC6 KRT28 KRTAP1-4 KRT31 LOC100505782 KRT12 GC17P040912
GH17F040858 1.3 Ensembl ENCODE 11.2 +28.0 27979 0.3 CTCF HDGF GTF2E2 CHD4 ZNF2 RAD21 CHAMP1 GTF3C2 ZNF121 FOXK2 ENSG00000266208 KRT20 KRT28 KRTAP1-5 KRT37 KRTAP1-4 KRT31 LOC100505782 KRT12 GC17P040912
GH17F040848 1.2 Ensembl ENCODE 10.9 +33.2 33190 6.9 PKNOX1 ATF1 ZNF133 FEZF1 CBX5 FOS YY2 JUNB REST TSHZ1 TMEM99 KRT20 KRT28 ENSG00000234477 KRT37 LOC100505782 KRT31 MED24 ENSG00000265359 GC17P040912
GH17F040908 1.2 FANTOM5 Ensembl ENCODE 10.7 -27.7 -27733 8.7 PKNOX1 ATF1 MLX ZFP64 ARID4B ZNF48 ZNF121 ZNF143 FOS DEK KRT23 TMEM99 KRTAP3-2 ENSG00000259623 KRT20 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17F040948 1.1 FANTOM5 Ensembl ENCODE 9.8 -69.5 -69471 11.7 PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF121 ZNF143 KRTAP3-2 KRT23 KRTAP2-1 KRT39 KRT40 KRTAP2-2 ENSG00000234477 KRTAP3-3 KRTAP1-5 KRTAP3-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRT20 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT20 Gene

Chromosome:
17
Start:
40,875,889 bp from pter
End:
40,885,243 bp from pter
Size:
9,355 bases
Orientation:
Minus strand

Genomic View for KRT20 Gene

Genes around KRT20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT20 Gene

Proteins for KRT20 Gene

  • Protein details for KRT20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35900-K1C20_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 20
    Protein Accession:
    P35900
    Secondary Accessions:
    • B2R6W7

    Protein attributes for KRT20 Gene

    Size:
    424 amino acids
    Molecular mass:
    48487 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Associates with KRT8.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT20 Gene

Post-translational modifications for KRT20 Gene

  • Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KRT20 (K20)
  • Cloud-Clone Corp. Antibodies for KRT20

No data available for DME Specific Peptides for KRT20 Gene

Domains & Families for KRT20 Gene

Gene Families for KRT20 Gene

Suggested Antigen Peptide Sequences for KRT20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35900

UniProtKB/Swiss-Prot:

K1C20_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT20: view

Function for KRT20 Gene

Molecular function for KRT20 Gene

UniProtKB/Swiss-Prot Function:
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Gene Ontology (GO) - Molecular Function for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 8359595
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT20: view

Phenotypes for KRT20 Gene

genes like me logo Genes that share phenotypes with KRT20: view

Animal Model Products

miRNA for KRT20 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT20

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT20 Gene

Localization for KRT20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT20 Gene COMPARTMENTS Subcellular localization image for KRT20 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 3
extracellular 2
nucleus 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10973561
GO:0005882 intermediate filament NAS 8359595
genes like me logo Genes that share ontologies with KRT20: view

Pathways & Interactions for KRT20 Gene

genes like me logo Genes that share pathways with KRT20: view

Pathways by source for KRT20 Gene

1 Cell Signaling Technology pathway for KRT20 Gene
1 Reactome pathway for KRT20 Gene

Gene Ontology (GO) - Biological Process for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0033554 cellular response to stress IEA --
GO:0045109 intermediate filament organization IMP 12857878
GO:0050708 regulation of protein secretion IEA --
genes like me logo Genes that share ontologies with KRT20: view

No data available for SIGNOR curated interactions for KRT20 Gene

Drugs & Compounds for KRT20 Gene

(10) Drugs for KRT20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for KRT20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT20: view

Transcripts for KRT20 Gene

mRNA/cDNA for KRT20 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT20 Gene

Keratin 20:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT20 Gene

No ASD Table

Relevant External Links for KRT20 Gene

GeneLoc Exon Structure for
KRT20
ECgene alternative splicing isoforms for
KRT20

Expression for KRT20 Gene

mRNA expression in normal human tissues for KRT20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT20 Gene

This gene is overexpressed in Colon - Transverse (x36.8) and Small Intestine - Terminal Ileum (x13.0).

Protein differential expression in normal tissues from HIPED for KRT20 Gene

This gene is overexpressed in Colon (15.2), Saliva (15.2), Rectum (15.0), and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT20 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT20 Gene:

KRT20

SOURCE GeneReport for Unigene cluster for KRT20 Gene:

Hs.84905

mRNA Expression by UniProt/SwissProt for KRT20 Gene:

P35900-K1C20_HUMAN
Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
genes like me logo Genes that share expression patterns with KRT20: view

Primer Products

No data available for Protein tissue co-expression partners for KRT20 Gene

Orthologs for KRT20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT20 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia KRT20 34 35
  • 81.81 (n)
mouse
(Mus musculus)
Mammalia Krt20 34 16 35
  • 80.82 (n)
rat
(Rattus norvegicus)
Mammalia Krt20 34
  • 80.73 (n)
dog
(Canis familiaris)
Mammalia KRT20 34 35
  • 80.33 (n)
oppossum
(Monodelphis domestica)
Mammalia KRT20 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRT20 34 35
  • 63.75 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:92061 35
  • 48 (a)
ManyToMany
cyt1 35
  • 47 (a)
ManyToMany
cyt1l 35
  • 47 (a)
ManyToMany
wu:fb17f05 35
  • 47 (a)
ManyToMany
zgc:109868 35
  • 47 (a)
ManyToMany
krt17 35
  • 46 (a)
ManyToMany
zgc:153629 35
  • 43 (a)
ManyToMany
krt15 35
  • 42 (a)
ManyToMany
zgc:92035 35
  • 42 (a)
ManyToMany
krt1-19d 35
  • 41 (a)
ManyToMany
zgc:136902 35
  • 40 (a)
ManyToMany
si:dkeyp-113d7.4 35
  • 39 (a)
ManyToMany
zgc:92533 35
  • 24 (a)
ManyToMany
BX469912.1 35
  • 22 (a)
ManyToMany
Species where no ortholog for KRT20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT20 Gene

ENSEMBL:
Gene Tree for KRT20 (if available)
TreeFam:
Gene Tree for KRT20 (if available)

Paralogs for KRT20 Gene

Variants for KRT20 Gene

Sequence variations from dbSNP and Humsavar for KRT20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036367 A colorectal cancer sample
rs7212483 --
VAR_064726 --

Structural Variations from Database of Genomic Variants (DGV) for KRT20 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT20 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT20 Gene

Human Gene Mutation Database (HGMD)
KRT20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT20 Gene

Disorders for KRT20 Gene

MalaCards: The human disease database

(126) MalaCards diseases for KRT20 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
merkel cell carcinoma
  • trabecular adenocarcinoma
ovarian brenner tumor
  • brenner tumor
lymphoepithelioma-like carcinoma
  • lymphoepithelial carcinoma
signet ring cell adenocarcinoma
  • signet ring carcinoma nos
glandular cystitis
  • cystitis glandularis
- elite association - COSMIC cancer census association via MalaCards
Search KRT20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT20

Genetic Association Database (GAD)
KRT20
Human Genome Epidemiology (HuGE) Navigator
KRT20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT20
genes like me logo Genes that share disorders with KRT20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT20 Gene

Publications for KRT20 Gene

  1. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PMID: 8359595) Moll R. … Franke W.W. (Differentiation 1993) 2 3 4 22 64
  2. Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PMID: 12857878) Zhou Q. … Omary M.B. (Mol. Biol. Cell 2003) 3 4 22 64
  3. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PMID: 10973561) Barrett A.W. … Berkovitz B.K.B. (Arch. Oral Biol. 2000) 3 4 22 64
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
  5. The clinical implications of MMP-11 and CK-20 expression in human breast cancer. (PMID: 19914229) Cheng C.W. … Shen C.Y. (Clin. Chim. Acta 2010) 3 22 64

Products for KRT20 Gene

Sources for KRT20 Gene

Content
Loading form....