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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT20 Gene

protein-coding   GIFtS: 57
GCID: GC17M039030

Keratin 20

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 201 2     Cytokeratin 202
Protein IT2 3     cytokeratin-202
CK-202 3     Keratin, Type I Cytoskeletal 202
K202 3     keratin-202
CD202 5     Cytokeratin-203
KRT212 5     Keratin-203
CK202     

External Ids:    HGNC: 204121   Entrez Gene: 544742   Ensembl: ENSG000001714317   OMIM: 6082185   UniProtKB: P359003   

Export aliases for KRT20 gene to outside databases

Previous GC identifers: GC17M038532 GC17M041208 GC17M038940 GC17M039405 GC17M036285 GC17M034826


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT20 Gene:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic
keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is
specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a
region of chromosome 17q12-q21. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT20 Gene: 
KRT20 (keratin 20) is a protein-coding gene. Diseases associated with KRT20 include ovarian large-cell neuroendocrine carcinoma, and seminal vesicle adenocarcinoma. GO annotations related to this gene include protein binding and structural constituent of cytoskeleton. An important paralog of this gene is BFSP2.

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900
Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When
phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)

Gene Wiki entry for KRT20 (Keratin 20) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT20 gene promoter:
         POU6F1 (c2)   Nkx2-5   NF-AT   AREB6   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT20 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT20 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039030:  view genomic region     (about GC identifiers)

Start:
39,032,141 bp from pter      End:
39,041,495 bp from pter
Size:
9,355 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 20  
Size: 424 amino acids; 48487 Da
Subunit: Heterotetramer of two type I and two type II keratins. Associates with KRT8
Subcellular location: Cytoplasm
Developmental stage: First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the
developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable
number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and
goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells
are negative
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: B2R6W7

Explore the universe of human proteins at neXtProt for KRT20: NX_P35900

Explore proteomics data for KRT20 at MOPED 

Post-translational modifications:

  • UniProtKB: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the
    later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By
    similarity)
  • UniProtKB: Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35900

  • KRT20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT20 Protein Expression
    REFSEQ proteins: NP_061883.1  
    ENSEMBL proteins: 
     ENSP00000167588  

    Human Recombinant Protein Products for KRT20: 
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    Novus Biologicals KRT20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for KRT20
    Cloud-Clone Corp. Proteins for KRT20 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10973561
    GO:0005882intermediate filament NAS8359595

    KRT20 for ontologies           About GeneDecksing



    KRT20 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for KRT20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P35900

    ProtoNet protein and cluster: P35900

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900
    Similarity: Belongs to the intermediate filament family


    KRT20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C20_HUMAN, P35900
    Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When
    phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton NAS8359595
    GO:0005515protein binding IPI16608857
         
    KRT20 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT20 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT20
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT20:
    hsa-miR-873 hsa-miR-876-5p hsa-miR-3921 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidKRT20 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/29 Interacting proteins for KRT20 (P359002, 3 ENSP000001675884) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66419 I2D: score=5 STRING: ENSP00000311695
    EIF4E2O605732, 3, ENSP000002584164MINT-67266 I2D: score=5 STRING: ENSP00000258416
    FXR2P511162, 3, ENSP000002501134MINT-68279 I2D: score=5 STRING: ENSP00000250113
    KRT15P190122, 3, ENSP000002540434MINT-66861 I2D: score=5 STRING: ENSP00000254043
    PRC1O436632, 3, ENSP000003777934MINT-67132 I2D: score=5 STRING: ENSP00000377793
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0033554cellular response to stress IEA--
    GO:0045109intermediate filament organization IMP12857878
    GO:0050708regulation of protein secretion IEA--

    KRT20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT20 (K1C20)

    10/17 Novoseek inferred chemical compound relationships for KRT20 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 78.6 7 11106075 (1), 9208972 (1), 9870855 (1), 19132778 (1) (see all 6)
    paraffin 53.9 21 10976695 (1), 10093825 (1), 11668468 (1), 10705819 (1) (see all 15)
    estrogen 50.7 57 11028811 (2), 12715337 (2), 9160304 (2), 12217766 (1) (see all 49)
    progesterone 50 45 9160304 (2), 12217766 (1), 14506675 (1), 15086841 (1) (see all 39)
    hematoxylin 47.5 9 12189500 (1), 10926813 (1), 15589579 (1), 15363204 (1) (see all 7)
    b 723 40.5 5 11106075 (2), 15589579 (1), 12481020 (1), 12647218 (1)
    ribonucleic acid 1.42 2 9817302 (1), 12498994 (1)
    tyrosine 1.03 1 16547650 (1)
    sucrose 0 3 17378731 (1)
    iron 0 2 16243134 (1), 18603673 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT20 / K1C20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT20 gene: 
    NM_019010.2  

    Unigene Cluster for KRT20:

    Keratin 20
    Hs.84905  [show with all ESTs]
    Unigene Representative Sequence: BC031559
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000167588(uc002hvl.3) ENST00000482529
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT20
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT20:
    hsa-miR-873 hsa-miR-876-5p hsa-miR-3921 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidKRT20 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT20
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    OriGene ORF clones in mouse, rat for KRT20
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    GenScript: all cDNA clones in your preferred vector: KRT20 (NM_019010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT20
    Sirion Biotech Customized lentivirus for stable overexpression of KRT20 
                         Customized lentivirus expression plasmids for stable overexpression of KRT20 
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    OriGene qPCR primer pairs and template standards for KRT20
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT20

    Additional mRNA sequence: 

    AK312744.1 BC031559.1 X73502.1 

    4 DOTS entries:

    DT.211402  DT.95162475  DT.120986558  DT.91829085 

    24/60 AceView cDNA sequences (see all 60):

    BX098834 AI821179 NM_019010 AA471027 AA522447 BC031559 BQ326166 BG386855 
    X73502 BQ316025 AI732381 AI732166 BI762148 BQ317223 T29686 AA133469 
    BI762117 AW842995 BQ316026 AA327537 BQ316024 AW853840 AA524060 BF759688 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT20 expression in normal human tissues (normalized intensities)      KRT20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTGCAA
    KRT20 Expression
    About this image


    KRT20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 4 entries
             small intestine ; glandular cells   
             small intestine   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             colonic mucosal (ibs)   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   

    See KRT20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT20

    SOURCE GeneReport for Unigene cluster: Hs.84905

    UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900
    Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic
    mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete
    ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT20 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt201 , 5 keratin 201, 5 80.82(n)1
    79.72(a)1
      11 (62.92 cM)5
    668091  NM_023256.11  NP_075745.11 
     994284035 
    chicken
    (Gallus gallus)
    Aves KRT201 keratin 20 63.59(n)
    57.45(a)
      420045  XM_418168.3  XP_418168.2 
    lizard
    (Anolis carolinensis)
    Reptilia KRT206
    keratin 20
    39(a)
    1 ↔ 1
    6(70410921-70423920)
    African clawed frog
    (Xenopus laevis)
    Amphibia M11032.12   -- 73.21(n)    M11032.1 


    ENSEMBL Gene Tree for KRT20 (if available)
    TreeFam Gene Tree for KRT20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT20 gene
    BFSP22  KRT182  KRT232  
    18/39 SIMAP similar genes for KRT20 using alignment to 1 protein entry:     K1C20_HUMAN(see all similar genes):
    JUP    KRT19    KRT13    KRT14    KRT31    KRT33A
    KRT33B    KRT34    KRT32    KRT15    KRT16    keratin
    KRT40    KRT35    KRT17    KRT37    KRTHA7    KRT9

    KRT20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/340 SNPs in KRT20 are shown (see all 340)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363674
    A colorectal cancer sample4--see VAR_0363672 S R mis40--------
    VAR_0647264
    ----see VAR_0647262 G C mis40--------
    rs346327221,2
    C--34831830(+) CACAC-/TGTGTGT 1 -- int10--------
    rs2012023651,2
    C--34831830(+) CACAC-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs1122483121,2
    C--34832479(+) CTTCCTTT/-TTTTT 1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs113954991,2
    C--39035060(+) TTTTTT/-GGGAC 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs2016354421,2
    C--39035060(+) TTTTTC/TTTTTT 1 -- int10--------
    rs665523241,2
    C--39037481(-) CAAAT-/ACACACA 1 -- int11Minor allele frequency- AC:0.00NA 2
    rs113087931,2
    C--39041698(+) GCAAC-/TTTTTT 1 -- us2k1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs25243101,2
    C,F,A,H--39818840(-) CCTTCT/GCAAGG 1 -- ds500120Minor allele frequency- G:0.42NS EA NA WA CSA 1348

    HapMap Linkage Disequilibrium report for KRT20 (39032141 - 39041495 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KRT20: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608218    OMIM disorders: --

    20/110 diseases for KRT20 (see all 110):    About MalaCards
    ovarian large-cell neuroendocrine carcinoma    seminal vesicle adenocarcinoma    infiltrative basal cell carcinoma    dermoid cyst of ovary
    cutaneous neuroendocrine carcinoma    pancreatic mucinous cystadenoma    cholangiolocellular carcinoma    malignant syringoma
    papillary serous adenocarcinoma    signet ring cell adenocarcinoma    medulloepithelioma    ovarian brenner tumor
    ampulla of vater adenocarcinoma    anal fistula    parachordoma    ovarian mucinous adenocarcinoma
    merkel cell carcinoma    horseshoe kidney    bile duct adenoma    ovarian mucinous neoplasm

    10 diseases from the University of Copenhagen DISEASES database for KRT20:
    Carcinoma     Skin cancer     Colorectal cancer     Pseudomyxoma peritonei
    Cholangiocarcinoma     Urinary bladder cancer     Dermoid cyst     Adenoma
    Ovarian Brenner tumor     Inverted papilloma

    KRT20 for disorders           About GeneDecksing

    10/94 Novoseek inferred disease relationships for KRT20 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma merkel cell 90.5 58 11175640 (5), 10027519 (4), 10728812 (4), 10976695 (2) (see all 29)
    carcinoma mucinous 81.7 20 12352188 (2), 14645698 (1), 14668551 (1), 15362373 (1) (see all 13)
    adenocarcinoma 81.6 279 15371952 (5), 11745209 (5), 15333652 (5), 18156982 (4) (see all 99)
    carcinoma 79.7 167 1371204 (5), 11341356 (4), 11419977 (3), 11488072 (3) (see all 99)
    metastatic carcinoma 79.2 25 12172048 (3), 9822920 (2), 9067104 (2), 14668551 (1) (see all 20)
    carcinoma neuroendocrine 79.2 16 20182342 (2), 15010880 (2), 10937047 (1), 16508780 (1) (see all 12)
    metastasis 76.1 152 11419977 (6), 16980943 (5), 17890913 (5), 17058136 (4) (see all 79)
    tumors 74.4 490 16980943 (7), 15245962 (7), 11301341 (7), 11144928 (6) (see all 99)
    extramammary pagets disease 73 5 9989849 (2), 10777264 (1)
    carcinoma transitional cell 71.2 23 9817302 (2), 11490230 (2), 9067104 (2), 11693559 (2) (see all 16)

    Genetic Association Database (GAD): KRT20
    Human Genome Epidemiology (HuGE) Navigator: KRT20 (2 documents)

    Export disorders for KRT20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT20 gene, integrated from 9 sources (see all 847):
    (articles sorted by number of sources associating them with KRT20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PubMed id 8359595)1, 2, 3, 9 Moll R.... Franke W.W. (1993)
    2. Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PubMed id 12857878)1, 2, 9 Zhou Q....Omary M.B. (2003)
    3. [Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients] (PubMed id 12515621)1, 3, 9 Ye X....Chen T. (2002)
    4. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PubMed id 10973561)1, 2, 9 Barrett A.W.... Berkovitz B.K.B. (2000)
    5. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    6. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    7. Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker. (PubMed id 16608857)1, 2 Zhou Q.... Omary M.B. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation. (PubMed id 7689500)1, 2 Calnek D. and Quaroni A. (1993)
    10. Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. (PubMed id 1696264)1, 2 Moll R.... Franke W.W. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54474 HGNC: 20412 AceView: KRT20 Ensembl:ENSG00000171431 euGenes: HUgn54474
    ECgene: KRT20 H-InvDB: KRT20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT20 gene:
    Search GeneIP for patents involving KRT20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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