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Aliases for KRT20 Gene

Aliases for KRT20 Gene

  • Keratin 20 2 3
  • Keratin 20, Type I 2 3 5
  • Cytokeratin-20 3 4
  • Protein IT 3 4
  • Keratin-20 3 4
  • CK-20 3 4
  • K20 3 4
  • Cytokeratin 20 3
  • KRT21 3
  • CK20 3
  • CD20 3

External Ids for KRT20 Gene

Previous GeneCards Identifiers for KRT20 Gene

  • GC17M038532
  • GC17M041208
  • GC17M038940
  • GC17M039405
  • GC17M036285
  • GC17M039030
  • GC17M034826

Summaries for KRT20 Gene

Entrez Gene Summary for KRT20 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT20 Gene

KRT20 (Keratin 20) is a Protein Coding gene. Diseases associated with KRT20 include Merkel Cell Carcinoma and Gastrointestinal Carcinoma. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT12.

UniProtKB/Swiss-Prot for KRT20 Gene

  • Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Gene Wiki entry for KRT20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT20 Gene

Genomics for KRT20 Gene

Regulatory Elements for KRT20 Gene

Enhancers for KRT20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT20 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT20 Gene

40,875,889 bp from pter
40,885,243 bp from pter
9,355 bases
Minus strand

Genomic View for KRT20 Gene

Genes around KRT20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT20 Gene

Proteins for KRT20 Gene

  • Protein details for KRT20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 20
    Protein Accession:
    Secondary Accessions:
    • B2R6W7

    Protein attributes for KRT20 Gene

    424 amino acids
    Molecular mass:
    48487 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Associates with KRT8.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT20 Gene

Proteomics data for KRT20 Gene at MOPED

Post-translational modifications for KRT20 Gene

  • Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT20 Gene

Domains & Families for KRT20 Gene

Gene Families for KRT20 Gene

Protein Domains for KRT20 Gene

Suggested Antigen Peptide Sequences for KRT20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT20: view

Function for KRT20 Gene

Molecular function for KRT20 Gene

UniProtKB/Swiss-Prot Function:
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Phenotypes for KRT20 Gene

GenomeRNAi human phenotypes for KRT20:
genes like me logo Genes that share phenotypes with KRT20: view

Animal Model Products

miRNA for KRT20 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT20 Gene

Localization for KRT20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT20 Gene


Subcellular locations from

Jensen Localization Image for KRT20 Gene COMPARTMENTS Subcellular localization image for KRT20 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 3
extracellular 2
nucleus 2
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for KRT20 Gene

Pathways & Interactions for KRT20 Gene

SuperPathways for KRT20 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with KRT20: view

Pathways by source for KRT20 Gene

1 Cell Signaling Technology pathway for KRT20 Gene

Gene Ontology (GO) - Biological Process for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033554 cellular response to stress IEA --
GO:0045109 intermediate filament organization IEA,IMP 12857878
genes like me logo Genes that share ontologies with KRT20: view

No data available for SIGNOR curated interactions for KRT20 Gene

Drugs & Compounds for KRT20 Gene

(10) Drugs for KRT20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for KRT20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT20: view

Transcripts for KRT20 Gene

mRNA/cDNA for KRT20 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT20 Gene

Keratin 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT20 Gene

No ASD Table

Relevant External Links for KRT20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT20 Gene

mRNA expression in normal human tissues for KRT20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT20 Gene

This gene is overexpressed in Colon - Transverse (x36.8) and Small Intestine - Terminal Ileum (x13.0).

Protein differential expression in normal tissues from HIPED for KRT20 Gene

This gene is overexpressed in Colon (15.2), Saliva (15.2), Rectum (15.0), and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT20 Gene

SOURCE GeneReport for Unigene cluster for KRT20 Gene Hs.84905

mRNA Expression by UniProt/SwissProt for KRT20 Gene

Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
genes like me logo Genes that share expression patterns with KRT20: view

Primer Products

No data available for Protein tissue co-expression partners for KRT20 Gene

Orthologs for KRT20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT20 35
  • 81.81 (n)
  • 76.4 (a)
KRT20 36
  • 54 (a)
(Canis familiaris)
Mammalia KRT20 35
  • 80.33 (n)
  • 71.33 (a)
KRT20 36
  • 70 (a)
(Mus musculus)
Mammalia Krt20 35
  • 80.82 (n)
  • 79.72 (a)
Krt20 16
Krt20 36
  • 78 (a)
(Pan troglodytes)
Mammalia KRT20 35
  • 99.37 (n)
  • 99.29 (a)
KRT20 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt20 35
  • 80.73 (n)
  • 81.28 (a)
(Monodelphis domestica)
Mammalia KRT20 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
-- 36
  • 49 (a)
(Gallus gallus)
Aves KRT20 35
  • 63.75 (n)
  • 57.92 (a)
KRT20 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
(Danio rerio)
Actinopterygii BX469912.1 36
  • 22 (a)
cyt1 36
  • 47 (a)
cyt1l 36
  • 47 (a)
krt1-19d 36
  • 41 (a)
krt15 36
  • 42 (a)
krt17 36
  • 46 (a)
si:dkeyp-113d7.4 36
  • 39 (a)
wu:fb17f05 36
  • 47 (a)
zgc:109868 36
  • 47 (a)
zgc:136902 36
  • 40 (a)
zgc:153629 36
  • 43 (a)
zgc:92035 36
  • 42 (a)
zgc:92061 36
  • 48 (a)
zgc:92533 36
  • 24 (a)
Species with no ortholog for KRT20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT20 Gene

Gene Tree for KRT20 (if available)
Gene Tree for KRT20 (if available)

Paralogs for KRT20 Gene

genes like me logo Genes that share paralogs with KRT20: view

Variants for KRT20 Gene

Sequence variations from dbSNP and Humsavar for KRT20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_024489 -
VAR_036367 A colorectal cancer sample
VAR_064726 -

Variation tolerance for KRT20 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT20 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRT20 Gene

Disorders for KRT20 Gene

MalaCards: The human disease database

(142) MalaCards diseases for KRT20 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
merkel cell carcinoma
  • trabecular adenocarcinoma
gastrointestinal carcinoma
dermoid cyst
  • cystic dermoid choristoma
mucinous adenocarcinoma
  • mucin-producing adenocarcinoma
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT20 Gene

Publications for KRT20 Gene

  1. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PMID: 8359595) Moll R. … Franke W.W. (Differentiation 1993) 2 3 4 23 67
  2. The clinical implications of MMP-11 and CK-20 expression in human breast cancer. (PMID: 19914229) Cheng C.W. … Shen C.Y. (Clin. Chim. Acta 2010) 3 23
  3. Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases. (PMID: 18813128) He H. … Chu P.G. (Appl. Immunohistochem. Mol. Morphol. 2009) 3 23
  4. [Expression of CK20 mRNA in the peripheral blood around postoperative chemotherapy in patients with gastric cancer and its clinical significance]. (PMID: 19145500) Qiao J.L. … Sun J. (Zhonghua Wei Chang Wai Ke Za Zhi 2009) 3 23
  5. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. (PMID: 19188603) Chan C.W. … Bodmer W.F. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for KRT20 Gene

Sources for KRT20 Gene