Aliases for KRT19 Gene
External Ids for KRT19 Gene
Previous GeneCards Identifiers for KRT19 Gene
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT19 Gene
KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include lung cancer and hepatocellular carcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT12.
UniProtKB/Swiss-Prot for KRT19 Gene
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.