Aliases for KRT19 Gene
External Ids for KRT19 Gene
Previous GeneCards Identifiers for KRT19 Gene
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT19 Gene
KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Lung Cancer and Thyroid Cancer. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT16.
UniProtKB/Swiss-Prot for KRT19 Gene
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.