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Aliases for KRT19 Gene

Aliases for KRT19 Gene

  • Keratin 19 2 3 5
  • 40-KDa Keratin Intermediate Filament 2 3
  • Keratin, Type I Cytoskeletal 19 2 3
  • Keratin, Type I, 40-Kd 2 3
  • Keratin 19, Type I 2 3
  • Cytokeratin 19 2 3
  • CK-19 3 4
  • K19 3 4
  • Cytokeratin-19 4
  • Keratin-19 4
  • CK19 3
  • K1CS 3

External Ids for KRT19 Gene

Previous GeneCards Identifiers for KRT19 Gene

  • GC17M039264
  • GC17P041708
  • GC17M039588
  • GC17M040053
  • GC17M036933
  • GC17M039679
  • GC17M035443

Summaries for KRT19 Gene

Entrez Gene Summary for KRT19 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT19 Gene

KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Lung Cancer and Thyroid Cancer. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT15.

UniProtKB/Swiss-Prot for KRT19 Gene

  • Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT19 Gene

Additional gene information for KRT19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT19 Gene

Genomics for KRT19 Gene

Regulatory Elements for KRT19 Gene

Enhancers for KRT19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H041518 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +3.1 3135 13 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B ZNF766 FOS SMARCE1 ENSG00000267758 KRT19 ACLY DHX58 KRT36 ENSG00000259623 KRT14 STAT5A STAT5B
GH17H040948 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +573.7 573676 11 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 TCF12 SLC30A9 ZNF143 KRTAP3-2 KRT23 KRTAP2-1 KRT39 KRT40 KRTAP2-2 ENSG00000234477 KRTAP3-3 KRTAP1-5 KRTAP3-1
GH17H041620 1.3 FANTOM5 ENCODE 12.3 -95.8 -95809 6 TBP PKNOX1 NFIB KLF17 BRCA1 GLIS2 ZNF366 RCOR1 KLF7 EGR2 KRT9 KRT15 KRT14 KRT19 KRT40 ENSG00000234477 KRT37 KRT16 KRT36 JUP
GH17H041649 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -126.3 -126257 9 HDGF ARNT ZNF133 YBX1 BRCA1 TCF12 GLIS2 ZNF207 ATF7 RUNX3 ENSG00000267758 JUP HSD17B1 DHX58 GHDC ENSG00000259623 KRT14 CNP PSMC3IP RETREG3
GH17H041534 1.4 FANTOM5 ENCODE dbSUPER 6.5 -8.9 -8854 5 PKNOX1 FOXA2 NFIB SIN3A NFXL1 BMI1 ZBTB7B ZNF121 RCOR1 HCFC1 ENSG00000267758 SMARCE1 KRT36 STAT5A KRT35 GHDC NAGLU KRT31 LOC100505782 KRT19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT19 on UCSC Golden Path with GeneCards custom track

Promoters for KRT19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094249 689 1401 ATF1 ARID4B SIN3A DMAP1 GLIS2 KLF7 ATF7 SP3 SP5 GTF2B

Genomic Location for KRT19 Gene

Chromosome:
17
Start:
41,523,617 bp from pter
End:
41,528,389 bp from pter
Size:
4,773 bases
Orientation:
Minus strand

Genomic View for KRT19 Gene

Genes around KRT19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT19 Gene

Proteins for KRT19 Gene

  • Protein details for KRT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08727-K1C19_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 19
    Protein Accession:
    P08727
    Secondary Accessions:
    • B2R874
    • Q5XG83
    • Q6NW33
    • Q7L5M9
    • Q96A53
    • Q96FV1
    • Q9BYF9
    • Q9P1Y4

    Protein attributes for KRT19 Gene

    Size:
    400 amino acids
    Molecular mass:
    44106 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT19 Gene

Post-translational modifications for KRT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KRT19 (Cytokeratin 19)
  • Cell Signaling Technology (CST) Antibodies for KRT19 (K19)

No data available for DME Specific Peptides for KRT19 Gene

Domains & Families for KRT19 Gene

Gene Families for KRT19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08727

UniProtKB/Swiss-Prot:

K1C19_HUMAN :
  • This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
  • Belongs to the intermediate filament family.
Domain:
  • This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT19: view

Function for KRT19 Gene

Molecular function for KRT19 Gene

GENATLAS Biochemistry:
keratin 19,type I (maybe included in KRTI),simple epithelia,hair follicle,nail bed
UniProtKB/Swiss-Prot Function:
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Ontology (GO) - Molecular Function for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 2448790
GO:0005515 protein binding IPI 15314064
GO:0008307 structural constituent of muscle IDA 16000376
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with KRT19: view
genes like me logo Genes that share phenotypes with KRT19: view

Animal Models for KRT19 Gene

MGI Knock Outs for KRT19:

Animal Model Products

CRISPR Products

miRNA for KRT19 Gene

miRTarBase miRNAs that target KRT19

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT19
  • Applied Biological Materials Clones for KRT19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KRT19 Gene

Localization for KRT19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT19 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 3
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0005886 plasma membrane IDA 23377137
GO:0016010 dystrophin-associated glycoprotein complex IEA --
GO:0016327 apicolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with KRT19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT19 Gene

Pathways & Interactions for KRT19 Gene

genes like me logo Genes that share pathways with KRT19: view

Pathways by source for KRT19 Gene

1 Cell Signaling Technology pathway for KRT19 Gene
1 BioSystems pathway for KRT19 Gene
2 Reactome pathways for KRT19 Gene

SIGNOR curated interactions for KRT19 Gene

Other effect:

Gene Ontology (GO) - Biological Process for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016032 viral process IEA --
GO:0031424 keratinization TAS --
GO:0043627 response to estrogen IEP 10037815
GO:0045214 sarcomere organization IDA 16000376
genes like me logo Genes that share ontologies with KRT19: view

Drugs & Compounds for KRT19 Gene

(24) Drugs for KRT19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(29) Additional Compounds for KRT19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT19: view

Transcripts for KRT19 Gene

Unigene Clusters for KRT19 Gene

Keratin 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KRT19
  • Applied Biological Materials Clones for KRT19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KRT19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: -
SP3: - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - -
SP7:

Relevant External Links for KRT19 Gene

GeneLoc Exon Structure for
KRT19
ECgene alternative splicing isoforms for
KRT19

Expression for KRT19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT19 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.4), Minor Salivary Gland (x6.6), Colon - Transverse (x6.3), Small Intestine - Terminal Ileum (x4.8), and Bladder (x4.7).

Protein differential expression in normal tissues from HIPED for KRT19 Gene

This gene is overexpressed in Salivary gland (10.7), Saliva (9.6), and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT19 Gene



Protein tissue co-expression partners for KRT19 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT19 Gene:

KRT19

SOURCE GeneReport for Unigene cluster for KRT19 Gene:

Hs.654568

mRNA Expression by UniProt/SwissProt for KRT19 Gene:

P08727-K1C19_HUMAN
Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Evidence on tissue expression from TISSUES for KRT19 Gene

  • Pancreas(5)
  • Intestine(4.8)
  • Lung(4.8)
  • Liver(4.6)
  • Skin(4.6)
  • Blood(4.5)
  • Eye(4.5)
  • Lymph node(4.5)
  • Kidney(3.8)
  • Stomach(3.6)
  • Thyroid gland(3.6)
  • Nervous system(3.6)
  • Gall bladder(3.3)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with KRT19: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT19 Gene

Orthologs for KRT19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT19 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia KRT19 33 34
  • 88.97 (n)
cow
(Bos Taurus)
Mammalia KRT19 33 34
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Krt19 33 16 34
  • 83.17 (n)
rat
(Rattus norvegicus)
Mammalia Krt19 33
  • 83 (n)
oppossum
(Monodelphis domestica)
Mammalia KRT19 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRT19 33 34
  • 72.57 (n)
lizard
(Anolis carolinensis)
Reptilia KRT19 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krt19 33
  • 71.21 (n)
Species where no ortholog for KRT19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT19 Gene

ENSEMBL:
Gene Tree for KRT19 (if available)
TreeFam:
Gene Tree for KRT19 (if available)

Paralogs for KRT19 Gene

Variants for KRT19 Gene

Sequence variations from dbSNP and Humsavar for KRT19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11550883 untested 41,528,158(-) GTCGC(C/T)TTTCG reference, synonymous-codon
rs200777034 untested 41,528,199(+) CAGGC(C/T)TCCGA reference, missense
rs267607654 untested 41,524,516(-) GCCAA(A/G)TGGGA reference, missense
rs267607655 untested 41,524,951(-) ATCAA(C/T)GGCCT reference, synonymous-codon
rs4601 untested 41,525,223(-) GACAA(C/T)GCCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KRT19 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv2760463 CNV gain 21179565
esv34903 CNV gain 17911159
esv3640588 CNV gain 21293372
esv3640589 CNV gain 21293372
nsv1062354 CNV gain 25217958
nsv1063389 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv442419 CNV gain 18776908
nsv510711 CNV deletion 20534489
nsv526466 CNV gain 19592680
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495
nsv978425 CNV duplication 23825009

Variation tolerance for KRT19 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT19 Gene

Disorders for KRT19 Gene

MalaCards: The human disease database

(66) MalaCards diseases for KRT19 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
thyroid cancer
  • malignant neoplasm of thyroid gland
follicular adenoma
  • follicular adenoma of the thyroid gland
papillary carcinoma
  • papillary carcinoma nos
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT19

Genetic Association Database (GAD)
KRT19
Human Genome Epidemiology (HuGE) Navigator
KRT19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT19
genes like me logo Genes that share disorders with KRT19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT19 Gene

Publications for KRT19 Gene

  1. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. (PMID: 10212274) Zhou X … Omary MB (The Journal of biological chemistry 1999) 3 4 22 60
  2. Universal markers of thyroid malignancies: galectin-3, HBME-1, and cytokeratin-19. (PMID: 20198455) Barut F … Ozdamar SO (Endocrine pathology 2010) 3 22 60
  3. KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (PMID: 19574886) Zhang L … Lloyd RV (The American journal of surgical pathology 2009) 3 22 60
  4. Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. (PMID: 19585610) Zhong B … Omary MB (Hepatology (Baltimore, Md.) 2009) 3 45 60
  5. Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy. (PMID: 19849844) Chang CC … Huang CJ (BMC cancer 2009) 3 22 60

Products for KRT19 Gene

  • Addgene plasmids for KRT19

Sources for KRT19 Gene

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