Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT19 Gene

Aliases for KRT19 Gene

  • Keratin 19, Type I 2 3
  • 40-KDa Keratin Intermediate Filament 2 3
  • Cytokeratin 19 2 3
  • Cytokeratin-19 3 4
  • Keratin-19 3 4
  • CK-19 3 4
  • K19 3 4
  • Keratin, Type I Cytoskeletal 19 3
  • Type I Cytoskeletal 19 2
  • Keratin, Type I, 40-Kd 3
  • Keratin 19 2
  • Keratin 2
  • Type I 2
  • 40-Kd 2
  • CK19 3
  • K1CS 3

External Ids for KRT19 Gene

Summaries for KRT19 Gene

Entrez Gene Summary for KRT19 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT19 Gene

KRT19 (Keratin 19, Type I) is a Protein Coding gene. Diseases associated with KRT19 include lung cancer and mixed ductal-endocrine carcinoma. Among its related pathways are Cytoskeletal Signaling and Signaling mediated by p38-alpha and p38-beta. GO annotations related to this gene include protein complex binding and structural constituent of muscle. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot for KRT19 Gene

  • Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT19 Gene

Genomics for KRT19 Gene

Genomic Location for KRT19 Gene

Start:
41,523,617 bp from pter
End:
41,528,389 bp from pter
Size:
4,773 bases
Orientation:
Minus strand

Genomic View for KRT19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT19 Gene

Regulatory Elements for KRT19 Gene

Proteins for KRT19 Gene

  • Protein details for KRT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08727-K1C19_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 19
    Protein Accession:
    P08727
    Secondary Accessions:
    • B2R874
    • Q5XG83
    • Q6NW33
    • Q7L5M9
    • Q96A53
    • Q96FV1
    • Q9BYF9
    • Q9P1Y4

    Protein attributes for KRT19 Gene

    Size:
    400 amino acids
    Molecular mass:
    44106 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)

neXtProt entry for KRT19 Gene

Proteomics data for KRT19 Gene at MOPED

Post-translational modifications for KRT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT19 Gene

Domains for KRT19 Gene

Gene Families for KRT19 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

UniProtKB/Swiss-Prot:

K1C19_HUMAN
Domain:
  • This keratin differs from all other IF proteins in lacking the C-terminal tail domain:
    • P08727
Family:
  • Belongs to the intermediate filament family.:
    • P08727
genes like me logo Genes that share domains with KRT19: view

Function for KRT19 Gene

Molecular function for KRT19 Gene

GENATLAS Biochemistry: keratin 19,type I (maybe included in KRTI),simple epithelia,hair follicle,nail bed
UniProtKB/Swiss-Prot Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Ontology (GO) - Molecular Function for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton TAS 2448790
GO:0005515 protein binding IPI 15846844
GO:0008307 structural constituent of muscle IDA 16000376
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with KRT19: view
genes like me logo Genes that share phenotypes with KRT19: view

miRNA for KRT19 Gene

miRTarBase miRNAs that target KRT19

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT19 Gene

Localization for KRT19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT19 Gene COMPARTMENTS Subcellular localization image for KRT19 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0005886 plasma membrane IDA 23377137
GO:0016010 dystrophin-associated glycoprotein complex IEA --
GO:0030018 Z disc IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with KRT19: view

Pathways for KRT19 Gene

genes like me logo Genes that share pathways with KRT19: view

Pathways by source for KRT19 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KRT19 Gene
1 Cell Signaling Technology pathway for KRT19 Gene
1 BioSystems pathway for KRT19 Gene

Gene Ontology (GO) - Biological Process for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0043627 response to estrogen IEP 10037815
GO:0045214 sarcomere organization IDA 16000376
GO:0060706 cell differentiation involved in embryonic placenta development IEA --
genes like me logo Genes that share ontologies with KRT19: view

Compounds for KRT19 Gene

(53) Novoseek inferred chemical compound relationships for KRT19 Gene

Compound -log(P) Hits PubMed IDs
smcc 54 1
hematoxylin 48.2 7
arotinoid 45.8 1
paraffin 39.8 15
acitretin 35 1
genes like me logo Genes that share compounds with KRT19: view

Transcripts for KRT19 Gene

Unigene Clusters for KRT19 Gene

Keratin 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: -
SP3: - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - -
SP7:

Relevant External Links for KRT19 Gene

GeneLoc Exon Structure for
KRT19
ECgene alternative splicing isoforms for
KRT19

Expression for KRT19 Gene

mRNA expression in normal human tissues for KRT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT19 Gene

This gene is overexpressed in Esophagus - Mucosa (7.4), Minor Salivary Gland (6.6), Colon - Transverse (6.3), Small Intestine - Terminal Ileum (4.8), and Bladder (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT19 Gene

SOURCE GeneReport for Unigene cluster for KRT19 Gene Hs.654568

mRNA Expression by UniProt/SwissProt for KRT19 Gene

P08727-K1C19_HUMAN
Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
genes like me logo Genes that share expressions with KRT19: view

Orthologs for KRT19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT19 36
  • 99.08 (n)
  • 99.5 (a)
KRT19 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT19 36
  • 88.35 (n)
  • 88.17 (a)
KRT19 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT19 36
  • 88.97 (n)
  • 89.22 (a)
KRT19 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt19 36
  • 83.17 (n)
  • 82.5 (a)
Krt19 16
Krt19 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT19 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt19 36
  • 83 (n)
  • 82 (a)
chicken
(Gallus gallus)
Aves KRT19 36
  • 72.57 (n)
  • 77.22 (a)
KRT19 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT19 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krt19 36
  • 71.21 (n)
  • 73.99 (a)
Species with no ortholog for KRT19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT19 Gene

ENSEMBL:
Gene Tree for KRT19 (if available)
TreeFam:
Gene Tree for KRT19 (if available)

Paralogs for KRT19 Gene

genes like me logo Genes that share paralogs with KRT19: view

Variants for KRT19 Gene

Sequence variations from dbSNP and Humsavar for KRT19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4601 untested 41,525,223(-) GACAA(C/T)GCCCG synonymous-codon, reference
rs4602 untested, - 41,528,069(-) GGGGG(C/G)CTACG reference, missense
rs897422 -- 41,528,587(+) CATAC(C/T)TGGAC upstream-variant-2KB
rs1869719 -- 41,524,328(+) AACAC(A/C)AAGCC intron-variant
rs1869720 -- 41,524,544(+) TCCTG(A/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT19 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
dgv962e1 CNV Complex 17122850
nsv510711 CNV Loss 20534489
nsv526466 CNV Gain 19592680
nsv9555 CNV Gain 18304495
nsv827992 CNV Gain 20364138
esv34903 CNV Gain 17911159
dgv963e1 CNV Complex 17122850
nsv442419 CNV CNV 18776908

Relevant External Links for KRT19 Gene

HapMap Linkage Disequilibrium report
KRT19

Disorders for KRT19 Gene

(97) Novoseek inferred disease relationships for KRT19 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 71.4 68
adenoma follicular 70.4 16
tumors 69.3 171
carcinoma papillary 69.1 44
carcinoma 68.3 79

Relevant External Links for KRT19

Genetic Association Database (GAD)
KRT19
Human Genome Epidemiology (HuGE) Navigator
KRT19
genes like me logo Genes that share disorders with KRT19: view

No data available for UniProtKB/Swiss-Prot for KRT19 Gene

Publications for KRT19 Gene

  1. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. (PMID: 10212274) Zhou X. … Omary M.B. (J. Biol. Chem. 1999) 3 4 23
  2. Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line. (PMID: 11682035) Kagaya M. … Kobayashi K. (J. Hepatol. 2001) 3 4 23
  3. Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. (PMID: 19585610) Zhong B. … Omary M.B. (Hepatology 2009) 3 23 49
  4. KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (PMID: 19574886) Zhang L. … Lloyd R.V. (Am. J. Surg. Pathol. 2009) 3 23
  5. Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma. (PMID: 19157505) Ahmad I. … Jain D. (Hum. Pathol. 2009) 3 23

Products for KRT19 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Breast Cancer in human,mouse,rat
    • Cell Lineage Identification in human,mouse,rat
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat
    • Terminal Differentiation Markers in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRT19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRT19
    • Block miRNA regulation of KRT19 using miScript Target Protectors
    • Addgene plasmids for KRT19

    Sources for KRT19 Gene

    Back to Top

    Content