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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT19 Gene

protein-coding   GIFtS: 67
GCID: GC17M039679

Keratin 19

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 191 2     CK192
40-KDa Keratin Intermediate Filament1 2     K1CS2
Cytokeratin 191 2     cytokeratin-192
CK-192 3     Keratin, Type I Cytoskeletal 192
K192 3     Keratin, Type I, 40-Kd2
40-kd1     keratin-192
keratin1     Cytokeratin-193
Type I1     Keratin-193
Type I Cytoskeletal 191     

External Ids:    HGNC: 64361   Entrez Gene: 38802   Ensembl: ENSG000001713457   OMIM: 1480205   UniProtKB: P087273   

Export aliases for KRT19 gene to outside databases

Previous GC identifers: GC17M039264 GC17P041708 GC17M039588 GC17M040053 GC17M036933 GC17M035443


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT19 Gene:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic
keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a
basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial
layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome
17q12-q21. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT19 Gene: 
KRT19 (keratin 19) is a protein-coding gene. Diseases associated with KRT19 include acute interstitial pneumonia, and anal canal adenocarcinoma, and among its related super-pathways are Cytoskeleton remodeling Keratin filaments. GO annotations related to this gene include structural constituent of muscle and protein complex binding. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot: K1C19_HUMAN, P08727
Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus
to dystrophin at the costameres of striated muscle

Gene Wiki entry for KRT19 (Keratin 19) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT19 gene promoter:
         PPAR-gamma1   AP-2alpha isoform 2   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT19 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT19 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039679:  view genomic region     (about GC identifiers)

Start:
39,679,869 bp from pter      End:
39,684,641 bp from pter
Size:
4,773 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C19_HUMAN, P08727 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 19  
Size: 400 amino acids; 44106 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of
DMD. Interacts with HCV core protein
Developmental stage: Present in hair follicles at all stages of development
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: B2R874 Q5XG83 Q6NW33 Q7L5M9 Q96A53 Q96FV1 Q9BYF9 Q9P1Y4

Explore the universe of human proteins at neXtProt for KRT19: NX_P08727

Explore proteomics data for KRT19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08727

  • KRT19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT19 Protein Expression
    REFSEQ proteins: NP_002267.2  
    ENSEMBL proteins: 
     ENSP00000355124   ENSP00000466625   ENSP00000408759  

    Human Recombinant Protein Products for KRT19: 
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    Novus Biologicals KRT19 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for KRT19
    Cloud-Clone Corp. Proteins for KRT19 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--
    GO:0016010dystrophin-associated glycoprotein complex IEA--
    GO:0030018Z disc IEA--
    GO:0042383sarcolemma IEA--
    GO:0043034costamere IDA16000376

    KRT19 for ontologies           About GeneDecksing



    KRT19 Antibody Products: 
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    R&D Systems Antibodies for KRT19 (Cytokeratin 19)
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    LSBio Antibodies in human, mouse, rat for KRT19 

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    Cloud-Clone Corp. ELISAs for KRT19 
    Cloud-Clone Corp. CLIAs for KRT19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    5 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P08727

    ProtoNet protein and cluster: P08727

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C19_HUMAN, P08727
    Domain: This keratin differs from all other IF proteins in lacking the C-terminal tail domain
    Similarity: Belongs to the intermediate filament family


    KRT19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C19_HUMAN, P08727
    Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus
    to dystrophin at the costameres of striated muscle

         Genatlas biochemistry entry for KRT19:
    keratin 19,type I (maybe included in KRTI@1),simple epithelia,hair follicle,nail bed

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS2448790
    GO:0005515protein binding IPI16000376
    GO:0008307structural constituent of muscle IDA16000376
    GO:0032403protein complex binding IEA--
         
    KRT19 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Krt19):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  integument  mortality/aging  nervous system  no phenotypic analysis 
     normal  reproductive system  skeleton  tumorigenesis 

    KRT19 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT19 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KRT19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91
    2Signaling mediated by p38-alpha and p38-beta
    Signaling mediated by p38-alpha and p38-beta
    3Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KRT19
        Cytoskeleton remodeling Keratin filaments


    1 Cell Signaling Technology (CST) Pathway for KRT19
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT19
        Cytoskeleton remodeling Keratin filaments

    1 BioSystems Pathway for KRT19
        Signaling mediated by p38-alpha and p38-beta




    KRT19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for KRT19 (P087271, 2, 3 ENSP000003551244) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM107AO959902, 3, ENSP000003542704MINT-68366 I2D: score=5 STRING: ENSP00000354270
    FANCGO152872, 3, ENSP000003679104MINT-68101 I2D: score=5 STRING: ENSP00000367910
    KRT15P190122, 3, ENSP000002540434MINT-67018 I2D: score=5 STRING: ENSP00000254043
    ZNF638Q149662, 3, ENSP000002644474MINT-67324 I2D: score=5 STRING: ENSP00000264447
    EXOC8Q8IYI62, 3, ENSP000003535644MINT-67176 I2D: score=4 STRING: ENSP00000353564
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0043627response to estrogen stimulus IEP10037815
    GO:0045214sarcomere organization IDA16000376
    GO:0060706cell differentiation involved in embryonic placenta development IEA--

    KRT19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT19 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT19 (K1C19)

    10/53 Novoseek inferred chemical compound relationships for KRT19 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    smcc 54 2 14652811 (1)
    hematoxylin 48.2 9 11519700 (1), 16006800 (1), 15659042 (1), 17851895 (1) (see all 7)
    arotinoid 45.8 1 1698888 (1)
    paraffin 39.8 18 7567941 (3), 16911464 (1), 9372313 (1), 15659042 (1) (see all 13)
    acitretin 35 1 17637822 (1)
    toluene diisocyanate 33.5 14 15478392 (6), 17191304 (2), 19187332 (1)
    glycogen 31.6 2 19781766 (1), 15144794 (1)
    matrigel 30.5 3 19513553 (1), 12021244 (1)
    estrogen 27.9 16 20044607 (2), 11026574 (2), 12481020 (1), 16086826 (1) (see all 12)
    b 723 26.8 3 12514785 (1), 12481020 (1), 12647218 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT19 / K1C19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT19 gene: 
    NM_002276.4  

    Unigene Cluster for KRT19:

    Keratin 19
    Hs.654568  [show with all ESTs]
    Unigene Representative Sequence: BQ073256
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361566(uc002hxd.4) ENST00000468880 ENST00000593096 ENST00000471565
    ENST00000479031 ENST00000455635 ENST00000462611
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT19

    Additional mRNA sequence: 

    AB041267.1 AB041268.1 AK313261.1 BC002539.2 BC007628.1 BC010409.2 BC067744.1 BC084574.1 
    Y00503.1 

    24/55 DOTS entries (see all 55):

    DT.100641390  DT.97863192  DT.102839922  DT.120986422  DT.91777282  DT.102839919  DT.91956476  DT.95308977 
    DT.91726920  DT.120986466  DT.120986024  DT.120986457  DT.120986319  DT.91911344  DT.97848055  DT.97847997 
    DT.120986146  DT.91827630  DT.120985849  DT.100670686  DT.121334571  DT.95148013  DT.120986130  DT.91982684 

    24/112 AceView cDNA sequences (see all 112):

    BQ931595 BM044831 BQ962606 BQ879510 BQ689873 BM810671 BU540563 BU157986 
    BG403246 BU196387 BM809792 BG222672 AI591139 BU527377 BU196975 BQ315832 
    BM810425 BG831983 BQ949556 AA357315 AA632038 BU944777 AW004947 BG289114 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KRT19 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
    SP1:                          -     -                                                                                 
    SP2:                                -                                                                                 
    SP3:                          -     -                             -     -                                             
    SP4:                                                                                                                  
    SP5:              -     -     -     -     -     -     -     -     -     -     -                                       


    ECgene alternative splicing isoforms for KRT19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT19 expression in normal human tissues (normalized intensities)      KRT19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATCAAGT
    KRT19 Expression
    About this image


    KRT19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/43 selected tissues (see all 43) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Lung (Respiratory System)    fully expand to see all 8 entries
             Trachea
             lung ; pneumocytes   
             Trachea   
     
     Epithelium (Uncategorized)    fully expand to see all 8 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             S-shaped Body
             Tubular cell-enriched subpopulation of renal cells
             Human Renal Mesangial Cells (HRMC)   
             visceral organ/metanephros/calyx   
     
     Liver (Hepatobiliary System)    fully expand to see all 6 entries
             Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
             Hepatic progenitor cells ( Functional hepatocyte generation from human embryonic...
             liver ; bile duct cells   

    See KRT19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT19

    SOURCE GeneReport for Unigene cluster: Hs.654568

    UniProtKB/Swiss-Prot: K1C19_HUMAN, P08727
    Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair
    follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts,
    gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein
    level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also
    seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical
    cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the
    sarcolemma in structures that contain dystrophin and spectrin

        SABiosciences Expression via Pathway-Focused PCR Arrays including KRT19: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Breast Cancer in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT19 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt191 , 5 keratin 191, 5 83.25(n)1
    82.75(a)1
      11 (63.42 cM)5
    166691  NM_008471.21  NP_032497.11 
     1001408105 
    chicken
    (Gallus gallus)
    Aves KRT191 keratin 19 73.16(n)
    77.72(a)
      395861  NM_205009.1  NP_990340.1 
    lizard
    (Anolis carolinensis)
    Reptilia KRT196
    keratin 19
    68(a)
    1 ↔ 1
    6(70647762-70661465)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480409812   -- 73.77(n)    48040981 


    ENSEMBL Gene Tree for KRT19 (if available)
    TreeFam Gene Tree for KRT19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT19 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT272  KRT322  KRT382  KRT362  KRT282  KRT142  KRT132  KRT262  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/58 SIMAP similar genes for KRT19 using alignment to 3 protein entries:     K1C19_HUMAN (see all proteins) (see all similar genes):
    keratin    KRT15    GUCA1B    K14    KRT33B    KRT31
    KRT34    KRT33A    KRT12    KRT17    JUP    KRT16
    KRT35    KRT20    KRT36    KRT24    KRT32    KRT10

    KRT19 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for KRT19
    PGOHUM00000238825 PGOHUM00000239898 PGOHUM00000245622 PGOHUM00000245653 PGOHUM00000243669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 SNPs in KRT19 are shown (see all 215)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2676076551,2
    Cuntested140468736(-) ATCAAC/TGGCCT 2 N syn10--------
    rs46011,2
    C,F,Huntested140469008(-) GACAAC/TGCCCG 2 N syn120Minor allele frequency- T:0.37MN NA WA CSA EA EU 6764
    rs46021,2,4
    C,F,A,Huntested140471854(-) GGGGGG/CCTACG 2 /A /G mis1 ese317Minor allele frequency- C:0.36MN NA EA NS CSA WA EU 5278
    rs115508831,2
    C,Funtested140471943(-) GTCGCT/CTTTCG 2 /A syn18Minor allele frequency- C:0.34NA WA CSA EA 367
    rs2007770341,2
    Cuntested140471984(+) CAGGCC/TTCCGA 2 S G mis11Minor allele frequency- T:0.00EU 299
    rs560519721,2
    C,Funtested140472131(+) GCGGCC/GGGTGG 1 -- ut515Minor allele frequency- G:0.27NA CSA WA 244
    rs1383820691,2
    C--35443995(+) GCGGT-/GGGGGG 1 -- int10--------
    rs1173064001,2
    C,F--39679391(+) ACATGC/GAGCTC 1 -- ds50011Minor allele frequency- G:0.06EA 120
    rs783444151,2
    C--39679656(+) GGAACG/AGGTTA 1 -- ds50013Minor allele frequency- A:0.03NA WA 240
    rs1401308921,2
    --39679738(+) CCTGGA/GACAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KRT19 (39679869 - 39684641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KRT19:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510711CNV Loss20534489
    esv34903CNV Gain17911159
    nsv9555CNV Gain18304495
    nsv526466CNV Gain19592680
    nsv827992CNV Gain20364138
    nsv442419CNV CNV18776908
    dgv962e1CNV Complex17122850
    dgv963e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148020    OMIM disorders: --

    20/126 diseases for KRT19 (see all 126):    About MalaCards
    acute interstitial pneumonia    anal canal adenocarcinoma    proliferating trichilemmal cyst    cholangiolocellular carcinoma
    mixed ductal-endocrine carcinoma    bile duct disease    limbal stem cell deficiency    hepatic adenoma
    hidrocystoma    osteofibrous dysplasia    pulmonary large cell neuroendocrine carcinoma    biliary tract disease
    cystic nephroma    follicular adenoma    breast carcinoma in situ    bile duct adenoma
    cholangiocarcinoma    papillary carcinoma    collecting duct carcinoma    neuroendocrine carcinoma

    8 diseases from the University of Copenhagen DISEASES database for KRT19:
    Carcinoma     Lung cancer     Breast cancer     Cholangiocarcinoma
    Thyroid cancer     Follicular adenoma     Hepatocellular carcinoma     Adenoma

    KRT19 for disorders           About GeneDecksing

    10/97 Novoseek inferred disease relationships for KRT19 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 71.4 73 9574953 (4), 8582085 (3), 17129430 (3), 10382940 (2) (see all 54)
    adenoma follicular 70.4 20 17308358 (2), 12446919 (2), 19213370 (2), 7520169 (2) (see all 12)
    tumors 69.3 425 19956064 (6), 20167095 (5), 15225427 (4), 19341176 (4) (see all 99)
    carcinoma papillary 69.1 53 12708901 (6), 12446919 (4), 11038428 (3), 10843292 (3) (see all 26)
    carcinoma 68.3 106 18095993 (4), 9833698 (3), 7509852 (2), 15272279 (2) (see all 63)
    cholangiocarcinoma 67.6 20 16168519 (3), 19094709 (2), 11743639 (2), 15362741 (2) (see all 12)
    thyroid papillary carcinoma 66.6 44 16998461 (4), 11038428 (3), 12746563 (3), 15716612 (3) (see all 20)
    nsclc 64.4 73 16809939 (4), 18646695 (4), 18080980 (4), 19662363 (3) (see all 35)
    metastasis 64.4 73 14593079 (3), 16788845 (3), 14556657 (2), 10741009 (2) (see all 47)
    breast cancer 63 193 15946491 (6), 19087676 (5), 10908152 (5), 9148421 (4) (see all 85)

    Genetic Association Database (GAD): KRT19
    Human Genome Epidemiology (HuGE) Navigator: KRT19 (3 documents)

    Export disorders for KRT19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT19 gene, integrated from 9 sources (see all 1134):
    (articles sorted by number of sources associating them with KRT19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. (PubMed id 10212274)1, 2, 9 Zhou X.... Omary M.B. (1999)
    2. Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19. (PubMed id 16000376)1, 2, 9 Stone M.R.... Bloch R.J. (2005)
    3. Keratin variants are overrepresented in primary bilia ry cirrhosis and associate with disease severity. (PubMed id 19585610)1, 4, 9 Zhong B....Omary M.B. (2009)
    4. Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line. (PubMed id 11682035)1, 2, 9 Kagaya M.... Kobayashi K. (2001)
    5. Genomic organization and amplification of the human keratin 15 and 19 genes. (PubMed id 10623642)1, 2, 9 Whittock N.V.... McGrath J.A. (2000)
    6. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Novel single nucleotide polymorphisms of the cytokeratin 19 pseudogene are associated with primary biliary cirrhosis. (PubMed id 12697249)1, 4 Daimon Y....Okanoue T. (2003)
    9. Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. (PubMed id 10809736)1, 2 Shi J. and Sugrue S.P. (2000)
    10. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3880 HGNC: 6436 AceView: KRT19 Ensembl:ENSG00000171345 euGenes: HUgn3880
    ECgene: KRT19 H-InvDB: KRT19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KRT19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT19 gene:
    Search GeneIP for patents involving KRT19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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