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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT18 Gene

protein-coding GIFtS: 67
GCID: GC12P053343

keratin 18

Explore 138 diseases affiliated with
KRT18 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 18¹ ²		Cytokeratin 18²
Cell Proliferation-Inducing Gene 46 Protein² ³		Cytokeratin-18³
CK-18² ³		Keratin, Type I Cytoskeletal 18²
CYK18² ³		Keratin-18³
K18² ³		Cytokeratin-18³
Cell Proliferation-Inducing Protein 46²		Keratin-18³

External Ids:	HGNC: 6430¹	Entrez Gene: 3875²	Ensembl: ENSG00000111057⁷	OMIM: 148070⁵	UniProtKB: P05783³

Export aliases for KRT18 gene to outside databases

Previous GC identifers: GC12M053340 GC12M053554 GC12P053059 GC12P051630 GC12P051631 GC12P051632 GC12P050386

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT18:

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin

8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single

layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript

variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When

phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma

membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

Gene Wiki entry for KRT18 (Keratin 18)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT18 gene promoter:
STAT3 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT18 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13

KRT18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT18 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P053343: view genomic region (about GC identifiers)

Start:	53,342,655 bp from pter	End:	53,346,685 bp from pter
Size:	4,031 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783 (See protein sequence)

Recommended Name: Keratin, type I cytoskeletal 18

Size: 430 amino acids; 48058 Da

Subunit: Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the

thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with

YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD

Subcellular location: Cytoplasm, perinuclear region. Nucleus, nucleolus

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to

basic; 56-70 kDa)

Secondary accessions: Q53G38 Q5U0N8 Q9BW26

Explore the universe of human proteins at neXtProt for KRT18: NX_P05783

Post-translational modifications:

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver.

Phosphorylation increases by IL-6¹

Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3,

caspase-6 or caspase-7¹

O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05783

KRT18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000215.1 NP_954657.1

ENSEMBL proteins:

ENSP00000447278 ENSP00000373487 ENSP00000373489

Human Recombinant Protein Products:

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	Novus Biologicals KRT18 Proteins Novus Biologicals KRT18 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for KRT18
	Uscn Proteins for KRT18

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005815	microtubule organizing center	IDA	18000879
GO:0005882	intermediate filament	IDA	10852826
GO:0034451	centriolar satellite	IDA	18000879

KRT18 for ontologies About GeneDecksing

KRT18 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT18
	R&D Systems Antibodies for KRT18 (Cytokeratin 18)
	Cell Signaling Technology (CST) Antibodies for KRT18 (K18)
	OriGene Antibodies (see all 9): KRT18 OriGene Custom Antibody Services for KRT18
	GenScript Custom Superior Antibodies Services for KRT18
	Novus Biologicals KRT18 Antibodies
	Abcam antibodies for KRT18
	Uscn Antibodies for KRT18
	ThermoFisher Antibody for KRT18

Assay Products for KRT18:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KRT18
	Enzo Life Sciences assays for KRT18
	Uscn ELISAs and CLIAs for KRT18

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT18 for domains About GeneDecksing

4 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR016044 F

Graphical View of Domain Structure for InterPro Entry P05783

ProtoNet protein and cluster: P05783

2 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When

phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma

membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

Induction: By IL6/interleukin-6

Genatlas biochemistry entry for KRT18:

keratin 18,type I,early embryonic simple epithelia,dimerizing with KRT8,including a 3' locus control region KRT18-LCR

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KRT18 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT18
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT18
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT18 (see all 7) OriGene shRNA RFP: KRT18 OriGene siRNA: KRT18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT18

Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KRT18
		Search LifeMap BioReagents cell lines for KRT18

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT18

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0097110	scaffold protein binding	IPI	10852826

KRT18 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KRT18:

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Krt18^tm1Tmm for KRT18
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Krt18):

embryogenesis

growth/size

liver/biliary system

mortality/aging

KRT18 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Keratin filaments

Cytoskeleton remodeling Keratin filaments

1.00

Cytoskeleton remodeling_Keratin filaments

0.91

Pathogenic Escherichia coli infection

Pathogenic Escherichia coli infection

1.00

Pathogenic Escherichia coli infection

0.98

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Rho Family GTPases

ILK Signaling

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KRT18

Cytoskeleton remodeling Keratin filaments

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KRT18

ILK Signaling

1 Cell Signaling Technology (CST) Pathway for KRT18

Cytoskeletal Signaling

1 GeneGo (Thomson Reuters) Pathway for KRT18

Cytoskeleton remodeling Keratin filaments

3 BioSystems Pathways for KRT18

	EGFR1 Signaling Pathway
	Pathogenic Escherichia coli infection
	Caspase cascade in apoptosis

1 Kegg Pathway (Kegg details for KRT18):

Pathogenic Escherichia coli infection

KRT18 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KRT18

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/172 Interacting proteins for KRT18 (P05783^{1, 2, 3} ENSP00000373487⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 172)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-67474 I2D: score=5 STRING: ENSP00000311695
KRT15	P19012²^,³, ENSP00000254043⁴	MINT-66577 I2D: score=5 STRING: ENSP00000254043
NME7	Q9Y5B8²^,³, ENSP00000356785⁴	MINT-68025 I2D: score=5 STRING: ENSP00000356785
EXOC8	Q8IYI6²^,³, ENSP00000353564⁴	MINT-67331 I2D: score=4 STRING: ENSP00000353564
DNAJB6	O75190¹^,³, ENSP00000262177⁴	EBI-297888,EBI-1053164 I2D: score=3 STRING: ENSP00000262177

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0009653	anatomical structure morphogenesis	TAS	2434380
GO:0019048	virus-host interaction	IEA	--
GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA	--

KRT18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KRT18 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT18
10/77 Novoseek chemical compound relationships for KRT18 gene (see all 77) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
new fuchsin	75.2	2	7521088 (1), 7682210 (1)
nash	55.7	25	19585618 (4), 19378390 (3), 19891019 (3), 19906783 (2) (see all 6)
griseofulvin	49.9	4	8770877 (3), 10952237 (1)
matrigel	41.8	1	12021244 (1)
paraffin	40.9	10	9816144 (1), 15597196 (1), 17912630 (1), 1694766 (1) (see all 8)
glycogen	35.4	6	17492221 (1), 19092233 (1), 19063660 (1), 19781766 (1)
dutp	33.7	2	12015537 (1), 15194561 (1)
diethyl dithiocarbamate	29.8	2	17187412 (2)
estrogen	28.4	6	18300793 (1), 18715613 (1), 20340005 (1), 18360284 (1) (see all 5)
progesterone	26.7	11	18300793 (1), 18715613 (1), 20340005 (1), 12835305 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about KRT18 / K1C18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRT18 gene (2 alternative transcripts):

NM_000224.2 NM_199187.1

Unigene Cluster for KRT18:

Keratin 18

Hs.406013 [show with all ESTs]

Unigene Representative Sequence: BF569100

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000550600(uc009zmn.2) ENST00000388835(uc001sbg.3) ENST00000549078

ENST00000548015 ENST00000546656 ENST00000548496 ENST00000388837(uc001sbe.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KRT18 Browse OriGene MicroRNA Expression Plasmids
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		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT18
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT18

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT18 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT18 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT18

Additional cDNA sequence:

AK129587.1 AK223093.1 AK308506.1 AK313988.1 AY762101.1 BC000180.2 BC000698.2 BC004253.1

BC008636.1 BC009754.2 BC020982.1 BC072017.1 BT019412.1 L32537.1 X12876.1 X12881.1

X12883.1

24/105 DOTS entries (see all 105):

DT.91779938 DT.91780003 DT.97824751 DT.97807695 DT.91779860 DT.97863493 DT.121117764 DT.91779932

DT.100772221 DT.121118642 DT.121117671 DT.100709494 DT.100700193 DT.450789 DT.121118265 DT.100700188

DT.100858944 DT.100860177 DT.100700176 DT.91779894 DT.121118049 DT.100700189 DT.121117823 DT.121118571

24/3236 AceView cDNA sequences (see all 3236):

BQ897000 BU174842 BE873483 BQ877765 BQ880178 BQ230504 BI088849 BP354378

BM749768 BU956388 BQ212577 BQ690976 BG122619 CA489262 BI090308 CB143059

BI252235 BI870976 BQ947912 CR594446 BG026356 BI257603 CR623563 BP356114

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KRT18 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	^	10a	·	10b
SP1:																	-
SP2:																	-																								-
SP3:			-		-												-
SP4:																	-
SP5:													-				-

ECgene alternative splicing isoforms for KRT18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAACCATCC

About this image

KRT18 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Trophoblast

Trophoblast Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Kidney

Ureteric Bud

Ureteric Bud Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)

Extraembryonic Tissues

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Hepatocyte-like cells (Functional hepatocyt...)

Extraembryonic endoderm-like cells (Generation of extrae...)

See KRT18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT18

SOURCE GeneReport for Unigene cluster: Hs.406013

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in

lymph nodes of breast carcinoma

SABiosciences Expression via Pathway-Focused PCR Arrays including KRT18:

Cell Surface Markers in human mouse rat

Breast Cancer in human mouse rat

Apoptosis 384HT in human mouse rat

Hepatotoxicity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT18

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT18

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KRT18 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Krt18^{1 , 5}	keratin 18^{1, 5}	85.35(n)¹ 88.6(a)¹		15 (57.22 cM)⁵ 16668¹ NM_010664.2¹ NP_034794.2¹ 102028216⁵
lizard (Anolis carolinensis)	Reptilia	KRT18⁶	--	62(a)	1 ↔ 1	GL343250.1(1886051-1901529)
African clawed frog (Xenopus laevis)	Amphibia	BC054993.1²	--	75.93(n)		BC054993.1
zebrafish (Danio rerio)	Actinopterygii	krt18²	keratin 18	77.52(n)		352912 BC045869.1

ENSEMBL Gene Tree for KRT18 (if available)
TreeFam Gene Tree for KRT18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT18 gene

KRT17² KRT13² KRT16² KRT26² KRT10² KRT12² KRT25² KRT27²

KRT15² KRT20² KRT24² KRT19² KRT9² KRT28² KRT14² KRT23²

18/59 SIMAP similar genes for KRT18 using alignment to 3 protein entries: K1C18_HUMAN (see all proteins) (see all similar genes):

FLJ40504 type I hair keratin K14 KRT31 KRT33A KRT33B

KRT15 KRT34 GUCA1B KRT13 KRT19 KRT14

keratin KRT40 KRT16 KRT32 KRT10 KRT35

KRT18 for paralogs About GeneDecksing

5/75 Pseudogenes.org Pseudogenes for KRT18 (see all 75)
PGOHUM00000242153 PGOHUM00000257807 PGOHUM00000257930 PGOHUM00000239498 PGOHUM00000258643

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58138700^1,2	C,	untested	53345947(+)	`CGCTAC/TGCCCT`	4	Y	syn¹		1		NA	3150
rs57370769^1,2		untested	53345972(+)	`TCAACA/GGGATC`	4	R G	mis¹		0	--	--	--	--
rs148580152^1,2	C	untested	53346565(+)	`CACCCG/ACCGGA`	4	/H /R	mis¹		1		NA	4516
rs142940942^1,2	C	other	53346569(+)	`CGCCGA/G/TATAGT`	6	R	syn¹		1		NA	4516
rs138920451^1,2		--	53345820(+)	`AGGTGC/GCCAAA`	2	--	int¹		0	--	--	--	--
rs149430536^1,2	C,	--	53345859(+)	`GTCCTA/GGGACT`	2	--	int¹		0	--	--	--	--
rs200668784^1,2		--	53345895(+)	`TGTGCC/TCCTGC`	2	--	int¹		0	--	--	--	--
rs144702029^1,2	C,	--	53346040(+)	`CAGGAA/GTATGA`	4	E	syn¹		0	--	--	--	--
rs147541172^1,2	C,F	--	53346096(+)	`CTACCG/ACCGCC`	4	/H /R	mis¹		1		NA	3168
rs11551627^1,2		--	53346098(+)	`ACCGCA/CGCCTG`	4	S R	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KRT18 (53342655 - 53346685 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT18: --
Human Gene Mutation Database (HGMD): KRT18

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT18

DNA2.0 Custom Variant and Variant Library Synthesis for KRT18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT18 for disorders           About GeneDecksing

OMIM gene information: 148070
OMIM disorders: 215600
UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600]

20/138 diseases for KRT18 (see all 138): About MalaCards

placental site trophoblastic tumor cirrhosis, noncryptogenic cirrhosis, cryptogenic bardet-biedl syndrome

microglandular adenosis age related macular degeneration non-small cell lung carcinoma pulmonary large cell neuroendocrine carcinoma

intermittent claudication botryoid rhabdomyosarcoma precocious puberty testicular germ cell tumor

nonalcoholic steatohepatitis carcinoma mammary paget's disease primitive neuroectodermal tumor

squamous cell carcinoma chromophobe renal cell carcinoma schneiderian carcinoma thymic epithelial tumor

3 diseases from the University of Copenhagen DISEASES database for KRT18:

Fatty liver disease Carcinoma Liver disease

10/96 Novoseek disease relationships for KRT18 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
liver diseases	60.7	23	17971926 (4), 19769633 (3), 17105587 (2), 19587454 (2) (see all 10)
tumors	59.3	158	19302716 (4), 11014572 (3), 15331168 (3), 16762691 (3) (see all 99)
carcinoma	59.1	49	19407366 (3), 11787851 (2), 7536188 (2), 11669590 (2) (see all 32)
epithelial tumor	55.2	3	15102669 (1), 7688814 (1)
fatty liver	49.8	11	19769633 (3), 19881359 (2), 18852641 (1), 19707105 (1) (see all 5)
breast carcinoma	49.3	13	9816144 (2), 17545523 (2), 10825002 (1), 18715613 (1) (see all 9)
carcinoma squamous cell	47.7	24	11038661 (4), 19755983 (2), 1690512 (2), 1374358 (1) (see all 17)
hepatitis alcoholic	46.5	5	16762691 (2), 15365314 (1), 19769633 (1), 18618253 (1)
metastasis	46.5	21	19529960 (5), 10825002 (1), 18715613 (1), 19615282 (1) (see all 7)
breast cancer	41.2	39	10209854 (4), 17545523 (4), 9816144 (2), 15102669 (2) (see all 21)

Genetic Association Database (GAD): KRT18
Human Genome Epidemiology (HuGE) Navigator: KRT18 (4 documents)

Export disorders for KRT18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRT18 gene, integrated from 9 sources (see all 815):
(articles sorted by number of sources associating them with KRT18)

Utopia: connect your pdf to the dynamic
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Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. (PubMed id 9524113)^{1, 2, 9} Ku N.O.... Omary M.B. (1998)
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. (PubMed id 9298992)^{1, 2, 9} Caulin C.... Oshima R.G. (1997)
Identification and mutational analysis of the glycosylation sites of human keratin 18. (PubMed id 7538124)^{1, 2, 9} Ku N.-O. and Omary M.B. (1995)
Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. (PubMed id 7523419)^{1, 2, 9} Ku N.O. and Omary M.B. (1994)
Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. (PubMed id 16424149)^{1, 2, 9} Lipecka J.... Davezac N. (2006)
Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane. (PubMed id 15529338)^{1, 2, 9} Davezac N.... Edelman A. (2004)
Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)^{1, 2, 9} Inada H.... Inagaki M. (2001)
Mutation of human keratin 18 in association with cryptogenic cirrhosis. (PubMed id 9011570)^{1, 2, 9} Ku N.-O.... Omary M.B. (1997)
Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PubMed id 1705144)^{1, 3, 9} Waseem A.... Lane E.B. (1990)
O-GlcNAcylation determines the solubility, filament o rganization, and stability of keratins 8 and 18. (PubMed id 20729549)^{1, 2} Srikanth B....Kalraiya R.D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3875	HGNC: 6430	AceView: KRT18	Ensembl:ENSG00000111057	euGenes: HUgn3875
ECgene: KRT18	Kegg: 3875	H-InvDB: KRT18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT18	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KRT18	Genetics and Cytogenetics in Oncology and Haematology
Human Intermediate Filament Mutation Database	http://www.interfil.org

Intellectual Property for KRT18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KRT18 gene:
Search GeneIP for patents involving KRT18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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keratin 18

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KRT18 Gene

keratin 18

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