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Aliases for KRT18 Gene

Aliases for KRT18 Gene

  • Keratin 18, Type I 2 3
  • Cell Proliferation-Inducing Gene 46 Protein 3 4
  • Cytokeratin-18 3 4
  • Keratin-18 3 4
  • CK-18 3 4
  • CYK18 3 4
  • K18 3 4
  • Cell Proliferation-Inducing Protein 46 3
  • Keratin, Type I Cytoskeletal 18 3
  • Cytokeratin 18 3
  • Keratin 18 2

External Ids for KRT18 Gene

Previous GeneCards Identifiers for KRT18 Gene

  • GC12M053340
  • GC12M053554
  • GC12P053059
  • GC12P051630
  • GC12P051631
  • GC12P051632
  • GC12P053343
  • GC12P050386

Summaries for KRT18 Gene

Entrez Gene Summary for KRT18 Gene

  • KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT18 Gene

KRT18 (Keratin 18, Type I) is a Protein Coding gene. Diseases associated with KRT18 include cirrhosis, cryptogenic and gallbladder sarcoma. Among its related pathways are ERK Signaling and Cytoskeletal Signaling. GO annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT23.

UniProtKB/Swiss-Prot for KRT18 Gene

  • Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Gene Wiki entry for KRT18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT18 Gene

Genomics for KRT18 Gene

Regulatory Elements for KRT18 Gene

Transcription factor binding sites by QIAGEN in the KRT18 gene promoter:

Genomic Location for KRT18 Gene

Start:
52,948,871 bp from pter
End:
52,952,901 bp from pter
Size:
4,031 bases
Orientation:
Plus strand

Genomic View for KRT18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT18 Gene

Proteins for KRT18 Gene

  • Protein details for KRT18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05783-K1C18_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 18
    Protein Accession:
    P05783
    Secondary Accessions:
    • Q53G38
    • Q5U0N8
    • Q9BW26

    Protein attributes for KRT18 Gene

    Size:
    430 amino acids
    Molecular mass:
    48058 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)

neXtProt entry for KRT18 Gene

Proteomics data for KRT18 Gene at MOPED

Post-translational modifications for KRT18 Gene

  • O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation
  • Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
  • Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
  • Ubiquitination at Lys81, Lys131, Lys167, and Lys247
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT18 Gene

No data available for DME Specific Peptides for KRT18 Gene

Domains for KRT18 Gene

Gene Families for KRT18 Gene

HGNC:
  • IFF1 :Intermediate filaments type I, keratins (acidic)

Suggested Antigen Peptide Sequences for KRT18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05783

UniProtKB/Swiss-Prot:

K1C18_HUMAN :
  • P05783
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT18: view

Function for KRT18 Gene

Molecular function for KRT18 Gene

GENATLAS Biochemistry: keratin 18,type I,early embryonic simple epithelia,dimerizing with KRT8,including a 3 locus control region KRT18-LCR
UniProtKB/Swiss-Prot Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
UniProtKB/Swiss-Prot Induction: By IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for KRT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 10852826
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0097110 scaffold protein binding IPI 10852826
genes like me logo Genes that share ontologies with KRT18: view

Phenotypes for KRT18 Gene

genes like me logo Genes that share phenotypes with KRT18: view

Animal Models for KRT18 Gene

MGI Knock Outs for KRT18:

miRNA for KRT18 Gene

miRTarBase miRNAs that target KRT18

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KRT18 Gene

Localization for KRT18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT18 Gene

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT18 Gene COMPARTMENTS Subcellular localization image for KRT18 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005882 intermediate filament IDA 10852826
genes like me logo Genes that share ontologies with KRT18: view

Pathways for KRT18 Gene

genes like me logo Genes that share pathways with KRT18: view

Pathways by source for KRT18 Gene

1 Qiagen pathway for KRT18 Gene
1 Cell Signaling Technology pathway for KRT18 Gene
1 KEGG pathway for KRT18 Gene
1 GeneGo (Thomson Reuters) pathway for KRT18 Gene

Gene Ontology (GO) - Biological Process for KRT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0009653 anatomical structure morphogenesis TAS 2434380
GO:0016032 viral process IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
GO:0043000 Golgi to plasma membrane CFTR protein transport IDA 15529338
genes like me logo Genes that share ontologies with KRT18: view

Compounds for KRT18 Gene

(77) Novoseek inferred chemical compound relationships for KRT18 Gene

Compound -log(P) Hits PubMed IDs
new fuchsin 75.2 2
nash 55.7 14
griseofulvin 49.9 4
matrigel 41.8 1
paraffin 40.9 8
genes like me logo Genes that share compounds with KRT18: view

Transcripts for KRT18 Gene

Unigene Clusters for KRT18 Gene

Keratin 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT18 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: -

Relevant External Links for KRT18 Gene

GeneLoc Exon Structure for
KRT18
ECgene alternative splicing isoforms for
KRT18

Expression for KRT18 Gene

mRNA expression in normal human tissues for KRT18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT18 Gene

This gene is overexpressed in Liver (6.8), Pancreas (6.7), and Colon - Transverse (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KRT18 Gene

SOURCE GeneReport for Unigene cluster for KRT18 Gene Hs.406013

mRNA Expression by UniProt/SwissProt for KRT18 Gene

P05783-K1C18_HUMAN
Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
genes like me logo Genes that share expressions with KRT18: view

Orthologs for KRT18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT18 35
  • 99.92 (n)
  • 100 (a)
KRT18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT18 35
  • 89.28 (n)
  • 88.81 (a)
KRT18 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT18 35
  • 89.59 (n)
  • 89.28 (a)
KRT18 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt18 35
  • 85.35 (n)
  • 88.6 (a)
Krt18 16
Krt18 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT18 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt18 35
  • 84.16 (n)
  • 86.46 (a)
chicken
(Gallus gallus)
Aves KRT18 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT18 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krt18 35
  • 65.23 (n)
  • 62.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11413 35
zebrafish
(Danio rerio)
Actinopterygii krt18 35
krt18 36
  • 52 (a)
OneToMany
KRT18 (2 of 3) 36
  • 52 (a)
OneToMany
KRT18 (3 of 3) 36
  • 42 (a)
OneToMany
zgc:77517 35
  • 59.26 (n)
  • 58.27 (a)
Species with no ortholog for KRT18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT18 Gene

ENSEMBL:
Gene Tree for KRT18 (if available)
TreeFam:
Gene Tree for KRT18 (if available)

Paralogs for KRT18 Gene

Paralogs for KRT18 Gene

genes like me logo Genes that share paralogs with KRT18: view

Variants for KRT18 Gene

Sequence variations from dbSNP and Humsavar for KRT18 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs17467 -- 52,952,287(-) CTCCA(C/G)CTTGA reference, missense
rs709170 -- 52,952,831(+) AAGTT(C/T)TGAGG reference, synonymous-codon
rs1063607 -- 52,952,777(+) CCACC(A/C)CCCGC reference, missense
rs2682294 -- 52,953,128(+) GGGAA(C/T)TGTGG downstream-variant-500B
rs3741442 -- 52,952,966(+) CAGTC(C/T)CATCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRT18 Gene

Variant ID Type Subtype PubMed ID
nsv832416 CNV Loss 17160897

Relevant External Links for KRT18 Gene

HapMap Linkage Disequilibrium report
KRT18
Human Gene Mutation Database (HGMD)
KRT18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT18 Gene

Disorders for KRT18 Gene

(1) OMIM Diseases for KRT18 Gene (148070)

UniProtKB/Swiss-Prot

K1C18_HUMAN
  • Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269 PubMed:12724528, ECO:0000269 PubMed:9011570}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for KRT18 Gene

(96) Novoseek inferred disease relationships for KRT18 Gene

Disease -log(P) Hits PubMed IDs
liver diseases 60.7 17
tumors 59.3 119
carcinoma 59.1 39
epithelial tumor 55.2 2
fatty liver 49.8 8

Relevant External Links for KRT18

Genetic Association Database (GAD)
KRT18
Human Genome Epidemiology (HuGE) Navigator
KRT18
genes like me logo Genes that share disorders with KRT18: view

Publications for KRT18 Gene

  1. Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. (PMID: 7523419) Ku N.O. … Omary M.B. (J. Cell Biol. 1994) 3 4 23
  2. Mutation of human keratin 18 in association with cryptogenic cirrhosis. (PMID: 9011570) Ku N.-O. … Omary M.B. (J. Clin. Invest. 1997) 3 4 23
  3. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. (PMID: 9298992) Caulin C. … Oshima R.G. (J. Cell Biol. 1997) 3 4 23
  4. Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. (PMID: 9524113) Ku N.O. … Omary M.B. (EMBO J. 1998) 3 4 23
  5. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PMID: 11684708) Inada H. … Inagaki M. (J. Cell Biol. 2001) 3 4 23

Products for KRT18 Gene

  • Addgene plasmids for KRT18

Sources for KRT18 Gene

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