Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT16 Gene

protein-coding   GIFtS: 60
GCID: GC17M039766

keratin 16
 Explore 49 diseases affiliated with
KRT16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRT16    

Aliases
for KRT16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin 161 2     Cytokeratin 162
NEPPK1 2     Cytokeratin-163
CK-162 3     Focal Non-Epidermolytic Palmoplantar Keratoderma2
K162 3     Keratin, Type I Cytoskeletal 162
KRT16A2 3     Keratin-163
FNEPPK2 5     Cytokeratin-163
CK162     Keratin-163
K1CP2     

External Ids:    HGNC: 64231   Entrez Gene: 38682   Ensembl: ENSG000001868327   OMIM: 1480675   UniProtKB: P087793   

Export aliases for KRT16 gene to outside databases

Previous GC identifers: GC17M020580 GC17M041881 GC17M039544 GC17M040139 GC17M037019 GC17M035529


Summaries
for KRT16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRT16:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair
keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic
keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin
14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are
associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar
verrucous nevus. (provided by RefSeq, Jul 2008)

Gene Wiki entry for KRT16 (Keratin 16)


Genomic Views
for KRT16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT16 gene promoter:
         TBP   STAT1   ATF-2   Pax-6   RREB-1   Lmo2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT16 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT16 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039766:  view genomic region     (about GC identifiers)

Start:
 39,766,030 bp from pter      End:
 39,772,151 bp from pter
Size:
 6,122 bases      Orientation:
 minus strand

Proteins
for KRT16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K1C16_HUMAN, P08779 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 16  
Size: 473 amino acids; 51268 Da
Subunit: Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers. Interacts with TCHP.
Interacts with TRADD (By similarity)
Mass spectrometry: Mass=50924.66; Method=MALDI; Range=2-473; Source=PubMed:11840567;
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)
(40-55 and 56-70 kDa, respectively)
Secondary accessions: A8K488 P30654 Q16402 Q9UBG8

Explore the universe of human proteins at neXtProt for KRT16: NX_P08779

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08779

    • KRT16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005548.2  
    ENSEMBL proteins: 
     ENSP00000301653   ENSP00000467124   ENSP00000467105  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KRT16
    OriGene Custom Protein Services for KRT16 
    GenScript Custom Purified and Recombinant Proteins Services for KRT16
    Novus Biologicals KRT16 Proteins
    Novus Biologicals KRT16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KRT16

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament NAS2451124


    KRT16 for ontologies           About GeneDecksing



    KRT16 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: KRT16
    OriGene Custom Antibody Services for KRT16 
    GenScript Custom Superior Antibodies Services for KRT16
    Novus Biologicals KRT16 Antibodies
    Abcam antibodies for KRT16 
    Uscn Antibodies for KRT16
    ThermoFisher Antibodies for KRT16

    Assay Products for KRT16: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT16
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KRT16

    Protein Domains /
    Families
    for KRT16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KRT16 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry P08779

    ProtoNet protein and cluster: P08779

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C16_HUMAN, P08779
    Similarity: Belongs to the intermediate filament family


    Function
    for KRT16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for KRT16:
    keratin 16,type I,hair follicle,nail bed,palmoplantar skin,suprabasal orogenital mucosal keratinocytes,dimerizing with
    KRT6A,KRT6B

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KRT16
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT16
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT16
    SwitchGear 3'UTR luciferase reporter plasmid: KRT16 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT16 (see all 4)
    OriGene shRNA RFP: KRT16
    OriGene siRNA: KRT16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT16

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KRT16

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KRT16 (NM_005557)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT16 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KRT16
    Search LifeMap BioReagents cell lines for KRT16

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT16

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton NAS2451124
    GO:0005515protein binding IPI15731013


    KRT16 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Krt16tm1(KOMP)Vlcg for KRT16
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Krt16):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     homeostasis/metabolism  integument  mortality/aging 

    KRT16 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KRT16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Keratin filaments
    		Cytoskeleton remodeling Keratin filaments1.00
    		Cytoskeleton remodeling_Keratin filaments0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KRT16
        Cytoskeleton remodeling Keratin filaments


    1 GeneGo (Thomson Reuters) Pathway for KRT16
        Cytoskeleton remodeling Keratin filaments



    KRT16 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/62 Interacting proteins for KRT16 (P087792, 3 ENSP000003016534) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928442, 3, ENSP000002590754MINT-48265 I2D: score=2 STRING: ENSP00000259075
    TCHPQ9BT923, ENSP000003244044I2D: score=1 STRING: ENSP00000324404
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS2451124
    GO:0008283cell proliferation TAS8595410
    GO:0008544epidermis development TAS7539673
    GO:0045104intermediate filament cytoskeleton organization IEA--


    KRT16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KRT16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT16 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT16
    10/18 Novoseek chemical compound relationships for KRT16 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcipotriol 72.1 1 8996256 (1)
    ttnpb 67.1 1 1698888 (1)
    dithranol 57.9 1 9167334 (1)
    retinoid 49.8 5 1370674 (1), 8915849 (1), 1698888 (1), 1376755 (1)
    clobetasol propionate 41.7 1 9055356 (1)
    retinoic acid 39.1 9 1698888 (2), 1370674 (1), 1711202 (1), 8647816 (1) (see all 6)
    betamethasone 33.5 1 12709818 (1)
    sodium dodecylsulfate 29.6 5 7547390 (1), 9686973 (1)
    isotretinoin 29.1 1 7967513 (1)
    1,25 dihydroxy vitamin d3 9.69 1 8996256 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT16 / K1C16 

    Transcripts
    for KRT16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KRT16 gene: 
    NM_005557.3  

    Unigene Cluster for KRT16:

    Keratin 16
    Hs.655160  [show with all ESTs]
    Unigene Representative Sequence: NM_005557
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301653(uc002hxg.4) ENST00000593067 ENST00000588319 ENST00000590990


    miRNA
    Products:             		 OriGene 3'-UTR Clone: KRT16
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT16
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT16
    SwitchGear 3'UTR luciferase reporter plasmid: KRT16 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT16 (see all 4)
    OriGene shRNA RFP: KRT16
    OriGene siRNA: KRT16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT16
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KRT16 (NM_005557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT16 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT16
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT16

    Additional cDNA sequence: 

    AF061812.1 AK290853.1 AK309278.1 AK309296.1 BC039169.1 S72493.2 S79867.1 

    24/36 DOTS entries (see all 36):

    DT.92325263  DT.92049602  DT.100776232  DT.95164435  DT.100776230  DT.120986389  DT.120986040  DT.120985802 
    DT.120985862  DT.95164389  DT.95282038  DT.120986391  DT.95252778  DT.120985764  DT.120985815  DT.120985831 
    DT.120985893  DT.91778161  DT.100776229  DT.100798819  DT.100798829  DT.102839919  DT.120930835  DT.120985847 

    24/659 AceView cDNA sequences (see all 659):

    CB151109 BG678738 BQ353873 AU117268 CR613905 CR603789 BG678485 BG673990 
    X62571 AU117282 BM982273 BQ330817 CR603127 CB151276 BG876919 AU119616 
    BU683797 BC000159 CA432895 BG680252 BM910160 CR621301 BI823396 H46592 

    GeneLoc Exon Structure


    Expression
    for KRT16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGCTGTCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KRT16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Early limb mesenchymal cells (ELM cells) (Primary Cell)Bone, Cartilage, Limb
    Mature airway epithelial cells (Directed differentia...)
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See KRT16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT16

    SOURCE GeneReport for Unigene cluster: Hs.655160

    UniProtKB/Swiss-Prot: K1C16_HUMAN, P08779
    Tissue specificity: Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and,
    suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland
    ducts

        SABiosciences Custom PCR Arrays for KRT16
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT16
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT16
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT16
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT16

    Orthologs
    for KRT16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KRT16 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NPR7_CHICK6
    F1NDP0_CHICK6
    		 Uncharacterized protein
    keratin 14 (epidermolysis bullosa simplex, Dowling...
    		 65(a)
    65(a)
    		 many ↔ many
    many ↔ many
    		 27(4280886-4284657)
    27(4274019-4277795)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 66(a)
    63(a)
    		 many ↔ many
    many ↔ many
    		 6(70844971-70856046)
    6(70865556-70875342)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.255562 Danio rerio cDNA clone MGC55334 IMAGE2601054, complete more 77.68(n)    BC044144.1 


    ENSEMBL Gene Tree for KRT16 (if available)
    TreeFam Gene Tree for KRT16 (if available) 

    Paralogs
    for KRT16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT16 gene
    KRT172  KRT132  KRT262  KRT102  KRT122  KRT182  KRT252  KRT152  
    KRT202  KRT272  KRT242  KRT192  KRT92  KRT282  KRT142  KRT232  
    18/51 SIMAP similar genes for KRT16 using alignment to 3 protein entries:     K1C16_HUMAN (see all proteins) (see all similar genes):
    keratin    KRT14    K14    GUCA1B    JUP    KRT17
    KRT15    KRT13    KRT19    KRT34    KRT33A    KRT12
    KRT31    KRT33B    KRT10    KRT35    KRT20    KRT32

    KRT16 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for KRT16
    PGOHUM00000236939 PGOHUM00000236963 PGOHUM00000236964 PGOHUM00000237255 PGOHUM00000237256


    Genomic Variants
    for KRT16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 NCBI SNPs in KRT16 are shown (see all 211)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289288941,2
    		Cpathogenic35574091(-) GACCAA/C/TGCAGA 3 K T M mis1 ese32NA 4
    rs593497731,2
    		Cpathogenic35574094(-) CATGCA/CGAACC 2 Q P mis10--------
    rs582936031,2
    		Cpathogenic35574100(-) GAACCA/C/G/T 
                CAATG     		4 H P R L mis10--------
    rs598562851,2
    		Cpathogenic35574108(-) ATGACC/TGCCTG 2 R C mis10--------
    rs574247491,2
    		Cpathogenic35574109(-) TGACCC/GCCTGG 2 P R mis10--------
    rs289288951,2
    		Cpathogenic35574112(-) CCGCCT/AGGCCT 2 /Q /L mis12Minor allele frequency- A:0.00NA 4
    rs609449491,2
    		Cpathogenic35574124(-) CTACCC/TGGACA 2 P L mis10--------
    rs593284511,2
    		C,F,pathogenic35575869(-) CAGAAA/TGCATC 2 K N mis11Minor allele frequency- T:0.00NA 3122
    rs1114367591,2
    		C,F,--35528630(+) ATGGGA/GGTCTT 1 -- ds50011Minor allele frequency- G:0.07NA 120
    rs739863291,2
    		C,--35528756(+) GCAACC/TTACTG 1 -- ds50011Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for KRT16 (39766030 - 39772151 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for KRT16
         5 CNVs: 88476 88475 3145 8845 4036
    Human Gene Mutation Database (HGMD): KRT16

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT16
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT16

    Disorders / Diseases
    for KRT16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KRT16 for disorders           About GeneDecksing

    OMIM gene information: 148067   
    OMIM disorders: 167200  600962  144200  613000  
    UniProtKB/Swiss-Prot: K1C16_HUMAN, P08779
  • Defects in KRT16 are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as
    • Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail
    dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma,
    follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present
  • Defects in KRT16 are the cause of palmoplantar keratoderma non-epidermolytic focal (FNEPPK) [MIM:613000]. A
    • dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on
    the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are
    often present
  • Defects in KRT16 are a cause of unilateral palmoplantar verrucous nevus (UPVN) [MIM:144200]. UPVN is
    • characterized by a localized thickening of the skin in parts of the right palm and the right sole
  • Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the
    • uterine cervix and in psoriasis vulgaris

    20/49 diseases for KRT16 (see all 49):    About MalaCards
    epidermolytic palmoplantar keratoderma    palmoplantar verrucous nevus    keratoderma    pachyonychia congenita
    palmoplantar verrucous nevus, unilateral    palmoplantar keratoderma, nonepidermolytic, focal    nevus    pachyonychia congenita type 2
    steatocystoma multiplex    pityriasis rubra pilaris    nonepidermolytic palmoplantar keratoderma    focal palmoplantar keratoderma
    middle ear cholesteatoma    lichen planus    epidermolytic acanthoma    epidermolytic hyperkeratosis
    epidermolysis bullosa simplex    molluscum contagiosum    oral lichen planus    acanthoma

    5 diseases from the University of Copenhagen DISEASES database for KRT16:
    Pachyonychia congenita     Keratosis     Psoriasis     Irritant dermatitis
    Epidermolysis bullosa simplex

    10/33 Novoseek disease relationships for KRT16 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pachyonychia congenita, type 1 92.7 3 9028791 (1), 11886499 (1), 10606845 (1)
    psoriasis 81.3 20 7577575 (4), 9167334 (1), 17089010 (1), 7516410 (1) (see all 13)
    keratoderma palmoplantar 76.8 2 9028791 (1)
    neppk 75.3 2 9028791 (1)
    pachyonychia congenita, type 2 74.9 2 9028791 (1), 11886499 (1)
    nail dystrophy 73.7 2 19609311 (1), 19785597 (1)
    palmoplantar keratoderma, epidermolytic 73.5 1 12688839 (1)
    hyperkeratosis 70.5 1 19171978 (1)
    acanthosis 68.6 1 9420535 (1)
    keratoderma 67.7 2 17719747 (1), 19785597 (1)

    GeneTests: KRT16
    Pachyonychia Congenita


    Export disorders for KRT16 gene to outside databases

    Publications
    for KRT16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT16 gene, integrated from 9 sources (see all 248):
    (articles sorted by number of sources associating them with KRT16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A group of type I keratin genes on human chromosome 17: characterization and expression. (PubMed id 2451124)1, 2, 3 Rosenberg M.... Fuchs E. (1988)
    2. Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma. (PubMed id 10839714)1, 2, 9 Smith F.J.... McLean W.H.I. (2000)
    3. Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. (PubMed id 11886499)1, 2, 9 Terrinoni A.... McLean W.H.I. (2001)
    4. Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1. (PubMed id 10521820)1, 2, 9 Smith F.J....McLean W.H.I. (1999)
    5. Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16. (PubMed id 11359398)1, 2, 9 Connors J.B.... Milstone L.M. (2001)
    6. Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1. (PubMed id 10606845)1, 2, 9 Smith F.J.D.... McLean W.H.I. (1999)
    7. A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. (PubMed id 10844556)1, 2, 9 Terrinoni A.... Melino G. (2000)
    8. Keratin 16 and keratin 17 mutations cause pachyonychia congenita. (PubMed id 7539673)1, 2, 9 McLean W.H.I....Munro C.S. (1995)
    9. Novel mutations in keratin 16 gene underly focal nonepidermolytic palmoplantar keratoderma (NEPPK) in two families. (PubMed id 8595410)1, 2, 9 Shamsheer M.K.... Leigh I.M. (1995)
    10. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)

    External Searches for KRT16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KRT16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3868 HGNC: 6423 AceView: KRT17andKRT14andKRT16 Ensembl:ENSG00000186832 euGenes: HUgn3868
    ECgene: KRT16 H-InvDB: KRT16

    Other Databases showing KRT16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KRT16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT16 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT16

    Intellectual Property
    for KRT16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KRT16 gene:
    Search GeneIP for patents involving KRT16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KRT16 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for KRT16   OriGene shRNA RFP for KRT16  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT16   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT16  
     OriGene Protein Over-expression Lysate for KRT16   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KRT16   OriGene 3'-UTR Clone for KRT16  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT16  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT16   OriGene Custom Protein Services for KRT16  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT16
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT16
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT16
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT16
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT16
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT16
     GenScript Custom Purified and Recombinant Proteins Services for KRT16 GenScript cDNA clones with any tag delivered in your preferred vector for KRT16
     GenScript Custom Assay Services for KRT16 GenScript Custom Superior Antibodies Services for KRT16
     GenScript Custom overexpressing Cell Line Services for KRT16 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KRT16 promoter
     Search Chromatin IP Primers for KRT16
     RT2 qPCR Primer Assay in human, mouse, rat KRT16
     GNC Network for KRT16
     SABiosciences Custom PCR Arrays for KRT16
     Search Tocris compounds for KRT16
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KRT16 antibodies
     KRT16 proteins
     KRT16 lysates
     Antibodies for KRT16
     See all of Abcam's Antibodies, Kits and Proteins for KRT16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KRT16 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KRT16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT16
     SwitchGear 3'UTR luciferase reporter plasmids for KRT16
     SwitchGear Promoter luciferase reporter plasmids for KRT16
     ThermoFisher Antibodies for KRT16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT16
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KRT16 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4