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KRT15 Gene

protein-coding   GIFtS: 57
GCID: GC17M039675

Keratin 15

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 151 2     K1CO2
Cytokeratin 151 2     cytokeratin-152
Type I Cytoskeletal 151 2     Keratin, Type I Cytoskeletal 152
CK-152 3     Keratin-15, Basic2
K152 3     Keratin-15, Beta2
basic1     Cytokeratin-153
beta1     KRTB3
keratin-151     Keratin-153
CK152     

External Ids:    HGNC: 64211   Entrez Gene: 38662   Ensembl: ENSG000001713467   OMIM: 1480305   UniProtKB: P190123   

Export aliases for KRT15 gene to outside databases

Previous GC identifers: GC17M039254 GC17P041715 GC17M039578 GC17M040043 GC17M036923 GC17M039674 GC17M035433


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT15 Gene:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of
heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT15 Gene:
KRT15 (keratin 15) is a protein-coding gene. Diseases associated with KRT15 include central centrifugal cicatricial alopecia, and hidrocystoma. GO annotations related to this gene include scaffold protein binding and structural constituent of cytoskeleton. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT15 (Keratin 15) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT15 gene promoter:
         PPAR-gamma1   p53   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT15 promoter sequence
   Search Chromatin IP Primers for KRT15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039675:  view genomic region     (about GC identifiers)

Start:
39,669,995 bp from pter      End:
39,678,781 bp from pter
Size:
8,787 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 15  
Size: 456 amino acids; 49212 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: B3KQY1 Q53XV8 Q9BUG4

Explore the universe of human proteins at neXtProt for KRT15: NX_P19012

Explore proteomics data for KRT15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002266.2  
    ENSEMBL proteins: 
     ENSP00000254043   ENSP00000377544   ENSP00000377546   ENSP00000409282   ENSP00000466687  
     ENSP00000467875   ENSP00000377550  

    KRT15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for KRT15
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    Novus Biologicals KRT15 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for KRT15

    KRT15 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT15
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for KRT15
    Novus Biologicals KRT15 Antibodies
    Abcam antibodies for KRT15 (P13646, P08779, P19012)
    Cloud-Clone Corp. Antibodies for KRT15
    ThermoFisher Antibody for KRT15
    LSBio Antibodies in human, mouse, rat for KRT15

    KRT15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for KRT15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT15
    Cloud-Clone Corp. CLIAs for KRT15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P19012

    ProtoNet protein and cluster: P19012

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012
    Similarity: Belongs to the intermediate filament family


    KRT15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for KRT15:
    keratin 15,type I,basal layer

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS2580298
    GO:0005515protein binding IPI16189514
    GO:0097110scaffold protein binding IPI10852826
         
    KRT15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT15

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT15:
    hsa-mir-340-3p (MIRT043849)

    Block miRNA regulation of human, mouse, rat KRT15 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KRT15:
    hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidKRT15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KRT15
    Predesigned siRNA for gene silencing in human, mouse, rat KRT15

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for KRT15

    Clone
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    OriGene clones in human, mouse for KRT15 (see all 6)
    OriGene ORF clones in mouse, rat for KRT15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT15 (NM_002275)
    Sino Biological Human cDNA Clone for KRT15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT15

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    KRT15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KRT15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53




        Pathway & Disease-focused RT2 Profiler PCR Array including KRT15: 
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KRT15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KRT15 (P190121, 2, 3 ENSP000002540434) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP2O756041, 3, ENSP000002601874EBI-739566,EBI-743272 I2D: score=6 STRING: ENSP00000260187
    ABI3Q9P2A42, 3, ENSP000002259414MINT-67148 I2D: score=5 STRING: ENSP00000225941
    ARCQ7LC442, 3, ENSP000003490224MINT-67831 I2D: score=5 STRING: ENSP00000349022
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-67641 I2D: score=5 STRING: ENSP00000262059
    HOXB6P175092, 3, ENSP000002256484MINT-67624 I2D: score=5 STRING: ENSP00000225648
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS2452170

    KRT15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT15 (K1C15)

    5 Novoseek inferred chemical compound relationships for KRT15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcipotriol 44.8 3 17199579 (3)
    atp 0 1 10098706 (1)
    tyrosine 0 4 10590133 (1)
    superoxide 0 1 18571648 (1)
    retinoic acid 0 1 15060141 (1)



    KRT15 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT15 gene: 
    NM_002275.3  

    Unigene Cluster for KRT15:

    Keratin 15
    Hs.654570  [show with all ESTs]
    Unigene Representative Sequence: AK122864
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254043(uc002hwy.3 uc002hwz.3) ENST00000393974(uc002hxa.3)
    ENST00000393976(uc002hxc.1) ENST00000474031(uc002hxb.1) ENST00000586794
    ENST00000458290 ENST00000463447 ENST00000497016 ENST00000470004 ENST00000393981

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT15 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KRT15:
    hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidKRT15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT15
    Predesigned siRNA for gene silencing in human, mouse, rat KRT15
    Clone
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    OriGene clones in human, mouse for KRT15 (see all 6)
    OriGene ORF clones in mouse, rat for KRT15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT15 (NM_002275)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KRT15
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT15
      QuantiTect SYBR Green Assays in human, mouse, rat KRT15
      QuantiFast Probe-based Assays in human, mouse, rat KRT15

    Additional mRNA sequence: 

    AK090604.1 AK122864.1 AL832226.1 BC002641.2 BT007261.1 X07696.1 

    20 DOTS entries:

    DT.445451  DT.86847047  DT.100797518  DT.40116971  DT.100797512  DT.100797514  DT.75102488  DT.97855980 
    DT.99968465  DT.120986421  DT.120986437  DT.100044410  DT.100797511  DT.100797513  DT.97864323  DT.120986135 
    DT.120986278  DT.75102489  DT.91778124  DT.92334226 

    9 AceView cDNA sequences:

    AU121873 BQ310924 NM_002275 BG876287 BU190306 BG742505 AI073908 AU147603 
    BF149105 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT15 expression in normal human tissues (normalized intensities)      KRT15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAGAA
    KRT15 Expression
    About this image


    KRT15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Corneal Epithelium
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     NULL (Uncategorized)
             Epithelial-like cells
    KRT15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654570

    UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012
    Tissue specificity: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but
    continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above
    the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus
    and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two
    layers of the suprabasal epithelium of the palate

        Pathway & Disease-focused RT2 Profiler PCR Array including KRT15: 
              Stem Cells in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat KRT15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT15 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt151 , 5 keratin 151, 5 87.25(n)1
    89.52(a)1
      11 (63.41 cM)5
    166651  NM_008469.21  NP_032495.21 
     1001317585 
    chicken
    (Gallus gallus)
    Aves KRT151 keratin 15 76.5(n)
    75.16(a)
      408040  NM_001001312.2  NP_001001312.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    6(70623216-70631496)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762822 hypothetical protein MGC76282 75.85(n)    BC061624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cki2 type I cytokeratin 78.26(n)   30328  AF197880.1 


    ENSEMBL Gene Tree for KRT15 (if available)
    TreeFam Gene Tree for KRT15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT15 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  
    KRT132  KRT262  KRT102  KRT122  KRT352  KRT242  KRT92  KRT33B2  
    KRT33A2  
    Selected SIMAP similar genes for KRT15 using alignment to 6 protein entries:     K1C15_HUMAN (see all proteins) (see all similar genes):
    KRT13    GUCA1B    KRT17    KRT16    KRT19    KRT14
    keratin    JUP    type I hair keratin    KRT33B    KRT31    K14
    KRT33A    KRT34    KRT35    KRT10    KRT36    KRT12

    KRT15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT15 (see all 272)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470233811,2
    Cuntested140460880(+) GAAGTA/C/TGTCCG 2 N D mis11NA 4552
    rs1865455781,2
    --40457033(+) AGCCCG/TGCTAC 1 -- ds50010--------
    rs776872721,2
    C,F--40457061(+) GGCCCG/AGGGCA 1 -- ds50011Minor allele frequency- A:0.12WA 118
    rs2009435521,2
    --40457101(+) TCATC-/TCTAAG 1 -- ds50010--------
    rs1464446321,2
    C--40457157(+) GAGCCC/TCATGG 1 -- ds50010--------
    rs1174832291,2
    C,F--40457166(+) GGGTGA/GGCGTG 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1917195041,2
    C--40457169(+) TGAGCA/GTGCCT 1 -- ds50010--------
    rs1835736381,2
    --40457194(+) CATGGA/GATGGC 1 -- ds50010--------
    rs1864976841,2
    --40457218(+) CAACGA/CGATCA 1 -- ds50010--------
    rs1172488471,2
    F--40457219(+) AACGCG/AATCAG 1 -- ds50011Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for KRT15 (39669995 - 39678781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for KRT15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483014CNV Loss15286789
    nsv510711CNV Loss20534489
    esv34903CNV Gain17911159
    nsv9555CNV Gain18304495
    nsv526466CNV Gain19592680
    nsv827992CNV Gain20364138
    nsv442419CNV CNV18776908
    dgv962e1CNV Complex17122850
    dgv963e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KRT15
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148030    OMIM disorders: --

    Selected diseases for KRT15 (see all 35):    About MalaCards
    central centrifugal cicatricial alopecia    hidrocystoma    kindler syndrome    spiradenoma
    syringocystadenoma papilliferum    pancreatoblastoma    castleman's disease    epithelioid sarcoma
    primary effusion lymphoma    phyllode tumor    oral lichen planus    cutaneous lupus erythematosus
    polymyalgia rheumatica    epidermolysis bullosa simplex    epidermolysis bullosa    lichen planus
    cervical intraepithelial neoplasia    graft versus host disease    basal cell carcinoma    kaposi's sarcoma

    4 diseases from the University of Copenhagen DISEASES database for KRT15:
    Syringocystadenoma papilliferum     Alopecia     Skin cancer     Spiradenoma

    KRT15 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for KRT15 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castleman disease 61.7 1 11752170 (1)
    carcinoma basal cell 54.3 7 10235375 (3), 18065959 (1), 18693153 (1), 10417438 (1) (see all 5)
    fibroadenoma 44.6 2 9150945 (1), 8932346 (1)
    psoriasis 29.8 3 10084315 (2)
    carcinoma squamous cell 29.6 3 18065959 (1), 12946229 (1), 18693153 (1)
    effusion 25.1 1 11752170 (1)
    graft-versus-host disease 23.8 1 14506658 (1)
    carcinoma 19.7 9 20190734 (5), 7536188 (1), 18065959 (1), 9150945 (1) (see all 5)
    lymphoma 14 2 11752170 (1), 10590133 (1)
    breast carcinoma 9.87 1 19383306 (1)


    Export disorders for KRT15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT15 gene, integrated from 10 sources (see all 135):
    (articles sorted by number of sources associating them with KRT15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. (PubMed id 10084315)1, 2, 9 Waseem A.... Leigh I.M. (J. Invest. Dermatol. 1999)
    2. Genomic organization and amplification of the human keratin 15 and 19 genes. (PubMed id 10623642)1, 2, 9 Whittock N.V.... McGrath J.A. (Biochem. Biophys. Res. Commun. 2000)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. (PubMed id 2468493)1, 2 Bader B.L.... Franke W.W. (Eur. J. Cell Biol. 1988)
    7. Molecular characterization and expression of the stratification- related cytokeratins 4 and 15. (PubMed id 2452170)1, 2 Leube R.E....Franke W.W. (J. Cell Biol. 1988)
    8. Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo. (PubMed id 10623468)1, 9 Werner S. and Munz B. (Exp. Cell Res. 2000)
    9. Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription. (PubMed id 15060141)1, 9 Radoja N....Blumenberg M. (Mol. Cell. Biol. 2004)
    10. Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (PubMed id 18789069)1, 9 Choi C.W....Cho K.H. (J. Dermatol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3866 HGNC: 6421 AceView: KRT15 Ensembl:ENSG00000171346 euGenes: HUgn3866
    ECgene: KRT15 H-InvDB: KRT15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT15 gene:
    Search GeneIP for patents involving KRT15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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