Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT15 Gene

protein-coding   GIFtS: 56
GCID: GC17M039675

keratin 15
 Explore 37 diseases affiliated with
KRT15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRT15    

Aliases
for KRT15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin 151 2     Keratin, Type I Cytoskeletal 152
K151 2 3     Keratin-15, Basic2
CK151 2     Keratin-15, Beta2
K1CO1 2     Type I Cytoskeletal 152
CK-152 3     Cytokeratin-153
Cytokeratin 152     KRTB3
Cytokeratin-153     Keratin-153

External Ids:    HGNC: 64211   Entrez Gene: 38662   Ensembl: ENSG000001713467   OMIM: 1480305   UniProtKB: P190123   

Export aliases for KRT15 gene to outside databases

Previous GC identifers: GC17M039254 GC17P041715 GC17M039578 GC17M040043 GC17M036923 GC17M039674 GC17M035433


Summaries
for KRT15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRT15:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair
keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic
keratin chains and are clustered in a region on chromosome 17q21.2. (provided by RefSeq, Jul 2008)

Gene Wiki entry for KRT15 (Keratin 15)


Genomic Views
for KRT15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT15 gene promoter:
         PPAR-gamma1   p53   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT15 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21-q23

KRT15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039675:  view genomic region     (about GC identifiers)

Start:
 39,669,995 bp from pter      End:
 39,678,781 bp from pter
Size:
 8,787 bases      Orientation:
 minus strand

Proteins
for KRT15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 15  
Size: 456 amino acids; 49212 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa)
Secondary accessions: B3KQY1 Q53XV8 Q9BUG4

Explore the universe of human proteins at neXtProt for KRT15: NX_P19012

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19012

    • KRT15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002266.2  
    ENSEMBL proteins: 
     ENSP00000254043   ENSP00000377544   ENSP00000377546   ENSP00000409282   ENSP00000466687  
     ENSP00000467875   ENSP00000377550  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KRT15
    OriGene Custom Protein Services for KRT15 
    GenScript Custom Purified and Recombinant Proteins Services for KRT15
    Novus Biologicals KRT15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KRT15

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament IEA--


    KRT15 for ontologies           About GeneDecksing



    KRT15 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT15
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): KRT15
    OriGene Custom Antibody Services for KRT15 
    GenScript Custom Superior Antibodies Services for KRT15
    Novus Biologicals KRT15 Antibodies
    Abcam antibodies for KRT15 
    Uscn Antibodies for KRT15
    ThermoFisher Antibody for KRT15

    Assay Products for KRT15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT15
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KRT15

    Protein Domains /
    Families
    for KRT15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KRT15 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry P19012

    ProtoNet protein and cluster: P19012

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012
    Similarity: Belongs to the intermediate filament family


    Function
    for KRT15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for KRT15:
    keratin 15,type I,basal layer

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KRT15
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT15
    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT15:
    hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmid: KRT15 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT15 (see all 7)
    OriGene shRNA RFP: KRT15
    OriGene siRNA: KRT15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT15

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KRT15

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KRT15 (NM_002275)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT15 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KRT15
    Search LifeMap BioReagents cell lines for KRT15

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT15

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS2580298
    GO:0005515protein binding IPI16189514
    GO:0097110scaffold protein binding IPI10852826


    KRT15 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KRT15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of p53
    		Selected targets of p531.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KRT15
        Selected targets of p53




    KRT15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for KRT15 (P190121, 2, 3 ENSP000002540434) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP2O756041, 3, ENSP000002601874EBI-739566,EBI-743272 I2D: score=6 STRING: ENSP00000260187
    ABI3Q9P2A42, 3, ENSP000002259414MINT-67148 I2D: score=5 STRING: ENSP00000225941
    ARCQ7LC442, 3, ENSP000003490224MINT-67831 I2D: score=5 STRING: ENSP00000349022
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-67641 I2D: score=5 STRING: ENSP00000262059
    HOXB6P175092, 3, ENSP000002256484MINT-67624 I2D: score=5 STRING: ENSP00000225648
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS2452170


    KRT15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KRT15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT15
    5 Novoseek chemical compound relationships for KRT15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcipotriol 44.8 3 17199579 (3)
    atp 0 1 10098706 (1)
    tyrosine 0 4 10590133 (1)
    superoxide 0 1 18571648 (1)
    retinoic acid 0 1 15060141 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT15 / K1C15 

    Transcripts
    for KRT15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KRT15 gene: 
    NM_002275.3  

    Unigene Cluster for KRT15:

    Keratin 15
    Hs.654570  [show with all ESTs]
    Unigene Representative Sequence: AK122864
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254043(uc002hwy.3 uc002hwz.3) ENST00000393974(uc002hxa.3)
    ENST00000393976(uc002hxc.1) ENST00000474031(uc002hxb.1) ENST00000586794
    ENST00000458290 ENST00000463447 ENST00000497016 ENST00000470004 ENST00000393981


    miRNA
    Products:             		 OriGene 3'-UTR Clone: KRT15
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT15
    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT15:
    hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmid: KRT15 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT15 (see all 7)
    OriGene shRNA RFP: KRT15
    OriGene siRNA: KRT15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT15
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KRT15 (NM_002275)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT15 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT15
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT15

    Additional cDNA sequence: 

    AK090604.1 AK122864.1 AL832226.1 BC002641.2 BT007261.1 X07696.1 

    20 DOTS entries:

    DT.445451  DT.86847047  DT.100797518  DT.40116971  DT.100797512  DT.100797514  DT.75102488  DT.97855980 
    DT.99968465  DT.120986421  DT.120986437  DT.100044410  DT.100797511  DT.100797513  DT.97864323  DT.120986135 
    DT.120986278  DT.75102489  DT.91778124  DT.92334226 

    9 AceView cDNA sequences:

    BG742505 BQ310924 AI073908 BU190306 NM_002275 AU121873 BG876287 AU147603 
    BF149105 

    GeneLoc Exon Structure


    Expression
    for KRT15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATAAAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KRT15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    BoneMandibular ProcessBone
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KRT15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT15

    SOURCE GeneReport for Unigene cluster: Hs.654570

    UniProtKB/Swiss-Prot: K1C15_HUMAN, P19012
    Tissue specificity: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but
    continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the
    hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and
    exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of
    the suprabasal epithelium of the palate

        SABiosciences Expression via Pathway-Focused PCR Array including KRT15: 
              Stem Cells in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT15
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT15
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT15

    Orthologs
    for KRT15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KRT15 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KRT151 keratin 15 71.22(n)
    69.48(a)    		   408040  NM_001001312.1  NP_001001312.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC762822 hypothetical protein MGC76282 75.85(n)    BC061624.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cki2 type I cytokeratin 78.26(n)   30328  AF197880.1 


    ENSEMBL Gene Tree for KRT15 (if available)
    TreeFam Gene Tree for KRT15 (if available) 

    Paralogs
    for KRT15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT15 gene
    KRT172  KRT132  KRT162  KRT262  KRT102  KRT122  KRT182  KRT252  
    KRT202  KRT272  KRT242  KRT192  KRT92  KRT282  KRT142  KRT232  
    18/57 SIMAP similar genes for KRT15 using alignment to 6 protein entries:     K1C15_HUMAN (see all proteins) (see all similar genes):
    KRT13    GUCA1B    KRT17    KRT16    KRT19    KRT14
    keratin    JUP    type I hair keratin    KRT33B    KRT31    K14
    KRT33A    KRT34    KRT35    KRT10    KRT36    KRT12

    KRT15 for paralogs           About GeneDecksing



    Genomic Variants
    for KRT15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in KRT15 are shown (see all 205)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1470233811,2
    		C,other35668753(+) GAAGTA/C/TGTCCG 3 N D Y mis11NA 4552
    rs776872721,2
    		F,--35433144(+) GGCCCG/AGGGCA 1 -- ds50011Minor allele frequency- A:0.12WA 118
    rs11313341,2
    		C,F,--35433626(-) NNNNTT/GTCCTT 1 -- ut311Minor allele frequency- G:0.02NA 120
    rs26621,2
    		C,F,A,H,--35433713(-) CTCTCC/ACCACC 1 -- ut31 ese311Minor allele frequency- A:0.12MN NS EA NA 1468
    rs760437911,2
    		F,--35433763(+) AAGACC/TGAGGG 1 -- ut311Minor allele frequency- T:0.02EA 120
    rs1129074601,2
    		--35434086(+) GCACCG/CCTGAG 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs778387251,2
    		F--35434458(+) AGGGGG/TTGGTG 1 -- int11Minor allele frequency- T:0.50NA 4
    rs761275121,2
    		F--35434459(+) GGGGGG/TGGTGG 1 -- int11Minor allele frequency- T:0.50NA 4
    rs18239961,2
    		C,F,A,--35434891(+) ACCACG/ACCCAG 1 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs1123034101,2
    		C--35435336(+) GCGCCA/TACTTG 1 -- int11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for KRT15 (39669995 - 39678781 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for KRT15
         6 CNVs: 0205 3145 37699 30831 8845 4036

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT15
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT15

    Disorders / Diseases
    for KRT15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KRT15 for disorders           About GeneDecksing

    OMIM gene information: 148030    OMIM disorders: --

    20/37 diseases for KRT15 (see all 37):    About MalaCards
    graft versus host disease    syringocystadenoma papilliferum    epidermolysis bullosa    epidermolysis bullosa simplex
    polymyalgia rheumatica    lichen planus    oral lichen planus    cervical intraepithelial neoplasia
    castleman's disease    primary effusion lymphoma    cutaneous lupus erythematosus    kindler syndrome
    pancreatoblastoma    hidrocystoma    spiradenoma    epithelioid sarcoma
    lupus erythematosus    nevus    trichoepithelioma    basal cell carcinoma

    4 diseases from the University of Copenhagen DISEASES database for KRT15:
    Syringocystadenoma papilliferum     Alopecia     Skin cancer     Spiradenoma

    10/14 Novoseek disease relationships for KRT15 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castleman disease 61.7 1 11752170 (1)
    carcinoma basal cell 54.3 7 10235375 (3), 18065959 (1), 18693153 (1), 10417438 (1) (see all 5)
    fibroadenoma 44.6 2 9150945 (1), 8932346 (1)
    psoriasis 29.8 3 10084315 (2)
    carcinoma squamous cell 29.6 3 18065959 (1), 12946229 (1), 18693153 (1)
    effusion 25.1 1 11752170 (1)
    graft-versus-host disease 23.8 1 14506658 (1)
    carcinoma 19.7 9 20190734 (5), 7536188 (1), 18065959 (1), 9150945 (1) (see all 5)
    lymphoma 14 2 11752170 (1), 10590133 (1)
    breast carcinoma 9.87 1 19383306 (1)


    Export disorders for KRT15 gene to outside databases

    Publications
    for KRT15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT15 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with KRT15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. (PubMed id 10084315)1, 2, 9 Waseem A.... Leigh I.M. (1999)
    2. Genomic organization and amplification of the human keratin 15 and 19 genes. (PubMed id 10623642)1, 2, 9 Whittock N.V.... McGrath J.A. (2000)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. (PubMed id 2468493)1, 2 Bader B.L.... Franke W.W. (1988)
    7. Molecular characterization and expression of the stratification- related cytokeratins 4 and 15. (PubMed id 2452170)1, 2 Leube R.E....Franke W.W. (1988)
    8. Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo. (PubMed id 10623468)1, 9 Werner S. and Munz B. (2000)
    9. Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription. (PubMed id 15060141)1, 9 Radoja N....Blumenberg M. (2004)
    10. Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (PubMed id 18789069)1, 9 Choi C.W....Cho K.H. (2008)

    External Searches for KRT15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KRT15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3866 HGNC: 6421 AceView: KRT15 Ensembl:ENSG00000171346 euGenes: HUgn3866
    ECgene: KRT15 H-InvDB: KRT15

    Other Databases showing KRT15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KRT15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KRT15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KRT15 gene:
    Search GeneIP for patents involving KRT15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KRT15 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT15
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for KRT15   OriGene shRNA RFP for KRT15  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT15   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT15  
     OriGene Protein Over-expression Lysate for KRT15   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KRT15   OriGene 3'-UTR Clone for KRT15  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT15  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT15   OriGene Custom Protein Services for KRT15  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT15
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT15
     GenScript Custom Purified and Recombinant Proteins Services for KRT15 GenScript cDNA clones with any tag delivered in your preferred vector for KRT15
     GenScript Custom Assay Services for KRT15 GenScript Custom Superior Antibodies Services for KRT15
     GenScript Custom overexpressing Cell Line Services for KRT15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KRT15 promoter
     Search Chromatin IP Primers for KRT15
     RT2 qPCR Primer Assay in human, mouse, rat KRT15
     GNC Network for KRT15
     SABiosciences PCR Arrays including human, mouse, rat KRT15
     Search Tocris compounds for KRT15
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KRT15 antibodies
     KRT15 lysates
     Antibodies for KRT15
     See all of Abcam's Antibodies, Kits and Proteins for KRT15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KRT15 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KRT15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT15
     SwitchGear 3'UTR luciferase reporter plasmids for KRT15
     SwitchGear Promoter luciferase reporter plasmids for KRT15
     ThermoFisher Antibody for KRT15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT15
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KRT15 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4