Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT14 Gene

protein-coding   GIFtS: 66
GCID: GC17M039738

Keratin 14

(Previous names: keratin 14 (epidermolysis bullosa simplex, Dowling-Meara,...)
(Previous symbols: EBS3, EBS4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 141 2     CK142
EBS31 2     NFJ2
EBS41 2     Cytokeratin 142
Keratin 14 (Epidermolysis Bullosa Simplex, Dowling-Meara, Koebner)1 2     cytokeratin-142
CK-142 3     Keratin, Type I Cytoskeletal 142
K142 3     keratin-142
Dowling-Meara1     Cytokeratin-143
Koebner1     Keratin-143
Epidermolysis Bullosa Simplex1     

External Ids:    HGNC: 64161   Entrez Gene: 38612   Ensembl: ENSG000001868477   OMIM: 1480665   UniProtKB: P025333   

Export aliases for KRT14 gene to outside databases

Previous GC identifers: GC17M038859 GC17P041732 GC17M039543 GC17M040111 GC17M036993 GC17M035501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT14 Gene:
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene
product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin.
Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated
with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. (provided by
RefSeq, Jul 2008)

GeneCards Summary for KRT14 Gene: 
KRT14 (keratin 14) is a protein-coding gene. Diseases associated with KRT14 include mammary paget's disease, and naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis, and among its related super-pathways are Cell-cell junction organization and Cytoskeleton remodeling Keratin filaments. GO annotations related to this gene include protein binding and structural constituent of cytoskeleton. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot: K1C14_HUMAN, P02533
Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large
bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro

Gene Wiki entry for KRT14 (Keratin 14) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT14 gene promoter:
         TBP   Sp1   AP-2alpha isoform 3   AP-2alpha isoform 2   C/EBPalpha   STAT3   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT14 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039738:  view genomic region     (about GC identifiers)

Start:
39,738,531 bp from pter      End:
39,743,173 bp from pter
Size:
4,643 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C14_HUMAN, P02533 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 14  
Size: 472 amino acids; 51561 Da
Subunit: Heterotetramer of two type I and two type II keratins. disulfide-linked keratin-14 associates with
keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins
Subcellular location: Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
1 PDB 3D structure from and Proteopedia for KRT14:
3TNU (3D)    
Secondary accessions: Q14715 Q53XY3 Q9BUE3 Q9UBN2 Q9UBN3 Q9UCY4

Explore the universe of human proteins at neXtProt for KRT14: NX_P02533

Explore proteomics data for KRT14 at MOPED 

Post-translational modifications:

  • UniProtKB: A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament
    cage around the nucleus
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02533

  • KRT14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT14 Protein Expression
    REFSEQ proteins: NP_000517.2  
    ENSEMBL proteins: 
     ENSP00000167586  
    Reactome Protein details: P02533
    Human Recombinant Protein Products for KRT14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KRT14
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KRT14
    GenScript Custom Purified and Recombinant Proteins Services for KRT14
    Novus Biologicals KRT14 Proteins
    Novus Biologicals KRT14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for KRT14
    Cloud-Clone Corp. Proteins for KRT14 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    KRT14 for ontologies           About GeneDecksing



    KRT14 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT14
    R&D Systems Antibodies for KRT14 (Cytokeratin 14)
    OriGene Antibodies for KRT14
    OriGene Custom Antibody Services for KRT14
    GenScript Custom Superior Antibodies Services for KRT14
    Novus Biologicals KRT14 Antibodies
    Abcam antibodies for KRT14
    Cloud-Clone Corp. Antibodies for KRT14 
    ThermoFisher Antibody for KRT14
    LSBio Antibodies in human, mouse, rat for KRT14 

    Assay Products for KRT14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KRT14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT14 
    Cloud-Clone Corp. CLIAs for KRT14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    5 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P02533

    ProtoNet protein and cluster: P02533

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C14_HUMAN, P02533
    Similarity: Belongs to the intermediate filament family


    KRT14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C14_HUMAN, P02533
    Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large
    bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro

         Genatlas biochemistry entry for KRT14:
    keratin 14,type I,basal layer,dimerizing with KRT5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS7525408
    GO:0005515protein binding IPI11684708
         
    KRT14 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Krt14):
     cellular  digestive/alimentary  homeostasis/metabolism  immune system  integument 
     mortality/aging  pigmentation  reproductive system  respiratory system  tumorigenesis 
     vision/eye 

    KRT14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Krt14tm1Efu for KRT14

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT14
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT14
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KRT14
    Sirion Biotech Customized adenovirus for overexpression of KRT14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KRT14 (see all 8)
    OriGene ORF clones in mouse, rat for KRT14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT14 (NM_000526)
    Sino Biological Human cDNA Clone for KRT14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT14
    Sirion Biotech Customized lentivirus for stable overexpression of KRT14 
                         Customized lentivirus expression plasmids for stable overexpression of KRT14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KRT14
    Search LifeMap BioReagents cell lines for KRT14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KRT14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    2Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91
    3Type I hemidesmosome assembly
    Type I hemidesmosome assembly
    4Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KRT14
        Cytoskeleton remodeling Keratin filaments


    1 GeneGo (Thomson Reuters) Pathway for KRT14
        Cytoskeleton remodeling Keratin filaments

    1 BioSystems Pathway for KRT14
        Glucocorticoid receptor regulatory network


    3        Reactome Pathways for KRT14
        Type I hemidesmosome assembly
    Cell junction organization
    Cell-Cell communication



    KRT14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/89 Interacting proteins for KRT14 (P025333 ENSP000001675864) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS7525408
    GO:0010043response to zinc ion IEA--
    GO:0010212response to ionizing radiation IEA--
    GO:0030855epithelial cell differentiation IEA--
    GO:0031581hemidesmosome assembly TAS--

    KRT14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT14 (K1C14)

    10/39 Novoseek inferred chemical compound relationships for KRT14 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 47.4 2 11136565 (1), 11023104 (1)
    progesterone 41.7 22 18536655 (1), 18715613 (1), 20340005 (1), 19479727 (1) (see all 20)
    hpvs 39.4 2 11774168 (1)
    calcipotriol 37.7 1 8615633 (1)
    estrogen 37.2 18 18375895 (2), 18536655 (1), 18715613 (1), 20340005 (1) (see all 14)
    hematoxylin 36.3 2 16679481 (1), 18305433 (1)
    isotretinoin 34.1 3 7967513 (1), 10983416 (1)
    retinoic acid 31.1 10 1711202 (1), 1284070 (1), 10983416 (1), 15482329 (1) (see all 6)
    paraffin 29.8 2 19319956 (1), 17912630 (1)
    retinoid 24.4 1 1376755 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT14 / K1C14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT14 gene: 
    NM_000526.4  

    Unigene Cluster for KRT14:

    Keratin 14
    Hs.654380  [show with all ESTs]
    Unigene Representative Sequence: BC042437
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000167586(uc002hxf.2) ENST00000441550 ENST00000476662
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT14
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT14
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT14
    Clone
    Products:
         
    OriGene clones in human, mouse for KRT14 (see all 8)
    OriGene ORF clones in mouse, rat for KRT14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT14 (NM_000526)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT14
    Sirion Biotech Customized lentivirus for stable overexpression of KRT14 
                         Customized lentivirus expression plasmids for stable overexpression of KRT14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KRT14
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT14

    Additional mRNA sequence: 

    AK309280.1 BC002690.2 BC019097.2 BC042437.1 BC094830.1 BT007186.1 M28646.1 

    24/86 DOTS entries (see all 86):

    DT.95164414  DT.91778104  DT.120985815  DT.91668763  DT.100798829  DT.97841180  DT.120986157  DT.92339664 
    DT.100798819  DT.120985939  DT.95164370  DT.97841197  DT.86843680  DT.100798830  DT.91849837  DT.120986284 
    DT.95206028  DT.120986429  DT.92397656  DT.95211715  DT.97841204  DT.100798837  DT.120986418  DT.91778130 

    24/659 AceView cDNA sequences (see all 659):

    BQ353870 BG675804 CA432895 CB128552 BG682247 BQ376870 BM979795 BQ352406 
    BG676127 BU683797 CR608685 AI609210 BC011901 CR608860 AU120147 BM018948 
    CB127326 BX403789 BG874631 BG677551 BX647923 AI127631 BM913705 AU117282 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT14 expression in normal human tissues (normalized intensities)      KRT14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTGCACG
    KRT14 Expression
    About this image


    KRT14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Epidermis (Integumentary System)    fully expand to see all 8 entries
             Basal Keratinocytes Embryonic Epidermis
             Stratified Epidermis
             Full-thickness skin substitutes
             Human EpiDermal Keratinocytes (HEK)   
     
     Lung (Respiratory System)    fully expand to see all 8 entries
             Basal Cells Trachea
             bronchus ; respiratory epithelial cells   
     
     Hair
             Primary Hair Placode Cells Hair Follicle
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Limbal corneal epithelial stem cells
             Human Corneal Epithelial Cells (HCEpiC)   
             sensory organ/eye/cornea   

    See KRT14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT14

    SOURCE GeneReport for Unigene cluster: Hs.654380

    UniProtKB/Swiss-Prot: K1C14_HUMAN, P02533
    Tissue specificity: Detected in the basal layer, lowered within the more apically located layers specifically in
    the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer
    root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in
    keratinocytes surrounding the club hair during telogen

        SABiosciences Expression via Pathway-Focused PCR Arrays including KRT14 (see all 6): 
              Notch Signaling Targets in human mouse rat
              Lung Cancer in human mouse rat
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KRT14
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT14 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt141 , 5 keratin 141, 5 90.58(n)1
    92.93(a)1
      11 (63.43 cM)5
    166641  NM_016958.11  NP_058654.11 
     1002031625 
    chicken
    (Gallus gallus)
    Aves KRT141 keratin 14 77.02(n)
    72.21(a)
      408039  NM_001001311.2  NP_001001311.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    68(a)
    67(a)
    many ↔ many
    many ↔ many
    6(70841228-70856140)
    6(70865282-70875799)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042927.12   -- 74.37(n)    BC042927.1 


    ENSEMBL Gene Tree for KRT14 (if available)
    TreeFam Gene Tree for KRT14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT14 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT132  KRT262  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/49 SIMAP similar genes for KRT14 using alignment to 1 protein entry:     K1C14_HUMAN(see all similar genes):
    K14    KRT16    GUCA1B    keratin    KRT15    JUP
    KRT13    KRT33A    KRT34    KRT10    KRT17    KRT20
    KRT31    KRT33B    KRT40    KRT9    KRT32    KRT39

    KRT14 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for KRT14
    PGOHUM00000236938 PGOHUM00000237076


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 SNPs in KRT14 are shown (see all 394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0104474
    Epidermolysis bullosa simplex, Koebner type (K-EBS)4--see VAR_0104472 A D mis40--------
    VAR_0237214
    Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)4--see VAR_0237212 R G mis40--------
    VAR_0038454
    Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)4--see VAR_0038452 L Q mis40--------
    VAR_0104524
    Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS)4--see VAR_0104522 E K mis40--------
    VAR_0104444
    Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)4--see VAR_0104442 R S mis40--------
    VAR_0038444
    Epidermolysis bullosa simplex, Koebner type (K-EBS)4--see VAR_0038442 Y H mis40--------
    VAR_0277194
    Epidermolysis bullosa simplex, Koebner type (K-EBS)4--see VAR_0277192 M T mis40--------
    VAR_0316384
    Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS)4--see VAR_0316382 Y C mis40--------
    VAR_0316394
    Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)4--see VAR_0316392 R P mis40--------
    VAR_0277214
    Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS)4--see VAR_0277212 R P mis40--------

    HapMap Linkage Disequilibrium report for KRT14 (39738531 - 39743173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for KRT14 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471400CNV Duplication19718026
    nsv2053CNV Insertion18451855
    esv22954CNV Loss19812545
    nsv9557CNV Loss18304495
    nsv827993CNV Loss20364138
    nsv9556CNV Gain18304495
    esv34903CNV Gain17911159
    nsv827992CNV Gain20364138
    dgv962e1CNV Complex17122850
    nsv514846CNV Complex21397061


    Human Gene Mutation Database (HGMD): KRT14
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KRT14
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148066   
    OMIM disorders: 131760  131900  601001  161000  125595  131800  
    UniProtKB/Swiss-Prot: K1C14_HUMAN, P02533
  • Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS) [MIM:131760]: A severe form of intraepidermal
    epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and
    mucous membrane involvement. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS) [MIM:131800]: A form of intraepidermal
    epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Epidermolysis bullosa simplex, Koebner type (K-EBS) [MIM:131900]: A form of intraepidermal epidermolysis
    bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the
    Dowling-Meara type, although it is less severe. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Epidermolysis bullosa simplex, autosomal recessive (AREBS) [MIM:601001]: An intraepidermal epidermolysis
    bullosa characterized by localized blistering on the dorsal, lateral and plantar surfaces of the feet. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Naegeli-Franceschetti-Jadassohn syndrome (NFJS) [MIM:161000]: A rare autosomal dominant form of
    ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous
    hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar
    keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy,
    and tooth enamel defects. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Dermatopathia pigmentosa reticularis (DPR) [MIM:125595]: A rare ectodermal dysplasia characterized by
    lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features
    include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 20/102 diseases for KRT14 (see all 102):    About MalaCards
    mammary paget's disease    naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis    sweat gland neoplasm    dermatopathia pigmentosa reticularis
    epidermolysis bullosa simplex, dowling-meara type    pleomorphic carcinoma    thyroid hurthle cell adenoma    epidermolysis bullosa simplex, localized
    epidermolysis bullosa simplex, recessive    cell type cancer    naegeli syndrome    epidermolysis bullosa simplex, other generalized
    mixed cell type cancer    myoepithelial carcinoma    epidermolysis bullosa simplex    epidermolysis bullosa simplex with mottled pigmentation
    basaloid squamous cell carcinoma    spiradenoma    epithelial-myoepithelial carcinoma    epidermolysis bullosa

    10 diseases from the University of Copenhagen DISEASES database for KRT14:
    Epidermolysis bullosa simplex     Carcinoma     Myoepithelioma     Breast cancer
    Papilloma     Thyroid hurthle cell adenoma     epithelial-myoepithelial carcinoma     Ductal carcinoma in situ
    Skin cancer     Syringoma

    KRT14 for disorders           About GeneDecksing

    10/84 Novoseek inferred disease relationships for KRT14 gene (see all 84)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermolysis bullosa simplex 96.2 80 10733662 (3), 12655565 (2), 7526933 (2), 11356849 (2) (see all 64)
    epidermolysis bullosa simplex, dowling-meara type 73.2 3 1721080 (1), 16439965 (1)
    epidermolysis bullosa 71.5 4 8435522 (1), 7537032 (1), 17476356 (1), 18713255 (1)
    myoepithelioma 70 3 7542546 (2), 12610349 (1)
    skin diseases genetic 62.8 1 17476356 (1)
    carcinoma 62.6 38 11859206 (5), 9833698 (3), 10534158 (2), 12207786 (1) (see all 22)
    hyperkeratosis 60.8 6 9804355 (2), 14987259 (1), 16356392 (1)
    carcinoma ductal 58.9 10 1384227 (2), 17522367 (1), 12884041 (1), 10680887 (1) (see all 8)
    papilloma 56.3 14 16698948 (3), 16990761 (1), 9614560 (1), 9754566 (1)
    carcinoma squamous cell 55.8 20 11454039 (3), 18067814 (2), 16273259 (2), 15313863 (1) (see all 14)

    GeneTests: KRT14
    GeneReviews: KRT14
    Genetic Association Database (GAD): KRT14
    Human Genome Epidemiology (HuGE) Navigator: KRT14 (2 documents)

    Export disorders for KRT14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT14 gene, integrated from 9 sources (see all 611):
    (articles sorted by number of sources associating them with KRT14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. (PubMed id 1717157)1, 2, 3 Coulombe P.A....Fuchs E. (1991)
    2. Exempting homologous pseudogene sequences from polymerase chain reaction amplification allows genomic keratin 14 hotspot analysis. (PubMed id 10733662)1, 2, 9 Hut P.H.L.... Scheffer H. (2000)
    3. Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations. (PubMed id 12655565)1, 2, 9 Schuilenga-Hut P.H.L.... Scheffer H. (2003)
    4. Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14. (PubMed id 16960809)1, 2, 9 Lugassy J.... Sprecher E. (2006)
    5. Epidermolysis bullosa simplex in Japanese and Korean patients: genetic studies in 19 cases. (PubMed id 16882168)1, 2, 9 Yasukawa K....Shimizu H. (2006)
    6. Identification of novel and known mutations in the genes for keratin 5 and 14 in Danish patients with epidermolysis bullosa simplex: correlation between genotype and phenotype. (PubMed id 9989794)1, 2, 9 Soerensen C.B.... Gregersen N. (1999)
    7. Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly. (PubMed id 16786515)1, 2, 9 Mueller F.B.... Arin M.J. (2006)
    8. Epidermolysis bullosa simplex in Israel: clinical and genetic features. (PubMed id 12707098)1, 2, 9 Ciubotaru D.... Sprecher E. (2003)
    9. A missense mutation in the rod domain of keratin 14 associated with recessive epidermolysis bullosa simplex. (PubMed id 7526933)1, 2, 9 Hovnanian A....Goossens M. (1993)
    10. Novel keratin 14 gene mutations in patients from Hungary with epidermolysis bullosa simplex. (PubMed id 14987259)1, 2, 9 Csikos M....Karpati S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3861 HGNC: 6416 AceView: KRT17andKRT14andKRT16 Ensembl:ENSG00000186847 euGenes: HUgn3861
    ECgene: KRT14 H-InvDB: KRT14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT14 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT14

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT14 gene:
    Search GeneIP for patents involving KRT14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT14
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KRT14 (Cytokeratin 14)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KRT14   OriGene RNAi products in human, mouse, rat for KRT14  
     OriGene qPCR primer pairs and template standards for KRT14   OriGene Protein Over-expression Lysate for KRT14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KRT14  
     OriGene qSTAR qPCR primer pairs in human, mouse for KRT14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KRT14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT14   OriGene Custom Protein Services for KRT14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT14
     QIAGEN SeqTarget long-range PCR primers for resequencing KRT14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT14
     GenScript Custom Purified and Recombinant Proteins Services for KRT14 GenScript cDNA clones with any tag delivered in your preferred vector for KRT14
     GenScript Custom Assay Services for KRT14 GenScript Custom Superior Antibodies Services for KRT14
     GenScript Custom overexpressing Cell Line Services for KRT14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KRT14 promoter
     Search Chromatin IP Primers for KRT14
     RT2 qPCR Primer Assay in human, mouse, rat KRT14
     GNC Network for KRT14
     SABiosciences PCR Arrays including human, mouse, rat KRT14
     Search Tocris compounds for KRT14 (K1C14)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for KRT14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KRT14 antibodies
     KRT14 proteins
     KRT14 lysates
     Antibodies for KRT14
     See all of Abcam's Antibodies, Kits and Proteins for KRT14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KRT14




     Proteins for KRT14
     Antibodies for KRT14
     ELISAs for KRT14
     CLIAs for KRT14
     Search LifeMap BioReagents cell lines for KRT14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT14
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KRT14
     SwitchGear Promoter luciferase reporter plasmids for KRT14
     ThermoFisher Antibody for KRT14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT14
    Customized:
     lentivirus for stable overexpression of KRT14
     lentivirus expression plasmids for stable overexpression of KRT14
     adenovirus for overexpression of KRT14
     LSBio Antibodies in human, mouse, rat for KRT14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KRT14 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4