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Aliases for KRT13 Gene

Aliases for KRT13 Gene

  • Keratin 13 2 3 5
  • Keratin, Type I Cytoskeletal 13 2 3
  • Keratin 13, Type I 2 3
  • Cytokeratin 13 2 3
  • CK-13 3 4
  • K13 3 4
  • Cytokeratin-13 4
  • Keratin-13 4
  • CK13 3
  • WSN2 3

External Ids for KRT13 Gene

Previous GeneCards Identifiers for KRT13 Gene

  • GC17M039241
  • GC17P041731
  • GC17M039565
  • GC17M040031
  • GC17M040033
  • GC17M036910
  • GC17M039657
  • GC17M035420

Summaries for KRT13 Gene

Entrez Gene Summary for KRT13 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT13 Gene

KRT13 (Keratin 13) is a Protein Coding gene. Diseases associated with KRT13 include White Sponge Nevus 2 and White Sponge Nevus 1. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT15.

Gene Wiki entry for KRT13 Gene

Additional gene information for KRT13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT13 Gene

Genomics for KRT13 Gene

Regulatory Elements for KRT13 Gene

Enhancers for KRT13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H041674 2 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -172.0 -172004 5.6 HNRNPUL1 HDGF PKNOX1 ARNT YBX1 ZNF2 YY1 ZNF766 CBX5 ZNF143 ENSG00000267758 RETREG3 NKIRAS2 DHX58 TTC25 STAT5A ACLY HSD17B1 KAT2A STAT3
GH17H041578 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4 -78.5 -78489 10.6 TBP PKNOX1 NFIB RAD21 ZNF143 ATF7 CREM EGR2 ZNF654 SP3 KRT16 JUP KRT36 KRT9 KRT14 KRT15 KRT17 KRT13 KRT19
GH17H040817 1 ENCODE 4.9 +686.2 686183 3.4 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 GATA2 ELK1 ATF7 RUNX3 TMEM99 KRT34 MED24 KRT13 KRT10
GH17H041620 1.3 FANTOM5 ENCODE 1.6 -118.5 -118493 6.5 TBP PKNOX1 NFIB KLF17 BRCA1 GLIS2 ZNF366 RCOR1 KLF7 EGR2 KRT9 KRT15 KRT14 KRT19 KRT40 ENSG00000234477 KRT37 KRT16 KRT36 JUP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT13 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT13 Gene

Genomic Locations for KRT13 Gene
4,725 bases
Minus strand

Genomic View for KRT13 Gene

Genes around KRT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT13 Gene

Proteins for KRT13 Gene

  • Protein details for KRT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 13
    Protein Accession:
    Secondary Accessions:
    • Q53G54
    • Q6AZK5
    • Q8N240

    Protein attributes for KRT13 Gene

    458 amino acids
    Molecular mass:
    49588 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Alternative splice isoforms for KRT13 Gene


neXtProt entry for KRT13 Gene

Post-translational modifications for KRT13 Gene

  • O-glycosylated; glycans consist of single N-acetylglucosamine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT13 Gene

No data available for DME Specific Peptides for KRT13 Gene

Domains & Families for KRT13 Gene

Gene Families for KRT13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT13: view

Function for KRT13 Gene

Molecular function for KRT13 Gene

GENATLAS Biochemistry:
keratin 13,major acidic keratin,type I,non cornifying mucosal epithelia (buccal,nasal,esophageal,anogenital)

Gene Ontology (GO) - Molecular Function for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with KRT13: view
genes like me logo Genes that share phenotypes with KRT13: view

Human Phenotype Ontology for KRT13 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT13 Gene

Localization for KRT13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT13 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IDA 9714826
GO:0045111 intermediate filament cytoskeleton IDA 21371075
genes like me logo Genes that share ontologies with KRT13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT13 Gene

Pathways & Interactions for KRT13 Gene

genes like me logo Genes that share pathways with KRT13: view

Pathways by source for KRT13 Gene

1 Cell Signaling Technology pathway for KRT13 Gene
2 Reactome pathways for KRT13 Gene
1 GeneGo (Thomson Reuters) pathway for KRT13 Gene

Gene Ontology (GO) - Biological Process for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IDA 21371075
GO:0009314 response to radiation IEA --
GO:0031424 keratinization TAS --
GO:0043587 tongue morphogenesis IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT13: view

No data available for SIGNOR curated interactions for KRT13 Gene

Drugs & Compounds for KRT13 Gene

(5) Drugs for KRT13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for KRT13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT13: view

Transcripts for KRT13 Gene

Unigene Clusters for KRT13 Gene

Keratin 13:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - -
SP4: -

Relevant External Links for KRT13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT13 Gene

This gene is overexpressed in Esophagus - Mucosa (x31.8), Vagina (x9.6), Cervix - Ectocervix (x5.9), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for KRT13 Gene

This gene is overexpressed in Saliva (29.6), Esophagus (29.2), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT13 Gene

Protein tissue co-expression partners for KRT13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT13 Gene:


SOURCE GeneReport for Unigene cluster for KRT13 Gene:


mRNA Expression by UniProt/SwissProt for KRT13 Gene:

Tissue specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

Evidence on tissue expression from TISSUES for KRT13 Gene

  • Nervous system(4.5)
  • Pancreas(4.3)
  • Liver(4.2)
  • Skin(2.6)
  • Eye(2.5)
  • Lung(2.3)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT13 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • digestive
  • integumentary
  • respiratory
Head and neck:
  • head
  • mouth
  • nose
  • pharynx
  • esophagus
  • rectum
  • vagina
  • skin
genes like me logo Genes that share expression patterns with KRT13: view

Primer Products

Orthologs for KRT13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT13 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia KRT13 33 34
  • 91.9 (n)
(Bos Taurus)
Mammalia KRT13 33
  • 89.23 (n)
(Mus musculus)
Mammalia Krt13 33 16 34
  • 88.19 (n)
(Rattus norvegicus)
Mammalia Krt13 33
  • 86.65 (n)
(Monodelphis domestica)
Mammalia KRT13 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia KRT13 34
  • 79 (a)
(Gallus gallus)
Aves KRT15 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt15 33
  • 64.68 (n)
Species where no ortholog for KRT13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT13 Gene

Gene Tree for KRT13 (if available)
Gene Tree for KRT13 (if available)

Paralogs for KRT13 Gene

Variants for KRT13 Gene

Sequence variations from dbSNP and Humsavar for KRT13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs59897026 Pathogenic, White sponge nevus 2 (WSN2) [MIM:615785] 41,505,219(-) GAACC(C/T)CAACG reference, missense
rs59970018 untested, White sponge nevus 2 (WSN2) [MIM:615785] 41,505,216(-) CCTCA(A/G)CGACC reference, missense
rs60364670 untested, White sponge nevus 2 (WSN2) [MIM:615785] 41,505,228(-) CACCA(C/T)GCAGA reference, missense
rs60440396 Pathogenic, White sponge nevus 2 (WSN2) [MIM:615785] 41,505,195(-) CTACC(C/T)GGAGA reference, missense
rs60906702 untested, White sponge nevus 2 (WSN2) [MIM:615785] 41,505,207(-) CCGCC(C/T)GGCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT13 Gene

Variant ID Type Subtype PubMed ID
nsv9555 CNV gain 18304495
nsv827992 CNV gain 20364138
nsv526466 CNV gain 19592680
nsv524606 CNV loss 19592680
nsv510711 CNV deletion 20534489
nsv483014 CNV loss 15286789
nsv1146669 OTHER inversion 26484159
esv3640589 CNV gain 21293372
esv3640588 CNV gain 21293372
esv34903 CNV gain 17911159
esv2758690 CNV gain+loss 17122850

Variation tolerance for KRT13 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT13 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT13 Gene

Disorders for KRT13 Gene

MalaCards: The human disease database

(29) MalaCards diseases for KRT13 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
white sponge nevus 2
  • wsn2
white sponge nevus 1
  • hereditary mucosal leukokeratosis
white sponge nevus of cannon, krt13-related
  • hereditary mucosal leukokeratosis, krt13-related
inverted papilloma
  • inverted papilloma, squamous cell
frontal sinus cancer
  • malignant neoplasm of frontal sinus
- elite association - COSMIC cancer census association via MalaCards
Search KRT13 in MalaCards View complete list of genes associated with diseases


  • White sponge nevus 2 (WSN2) [MIM:615785]: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. {ECO:0000269 PubMed:10561721, ECO:0000269 PubMed:11379896, ECO:0000269 PubMed:14600690, ECO:0000269 PubMed:7493031}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT13: view

No data available for Genatlas for KRT13 Gene

Publications for KRT13 Gene

  1. Identification of two novel mutations in keratin 13 as the cause of white sponge naevus. (PMID: 10561721) Rugg E … Lane E (Oral diseases 1999) 3 4 22 60
  2. Isolation, sequence and expression of the gene encoding human keratin 13. (PMID: 9714826) Waseem A … Waseem NH (Gene 1998) 3 4 22 60
  3. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. (PMID: 7493031) Richard G … Compton JG (Nature genetics 1995) 3 4 22 60
  4. [Immunofluorescence examination of CK-13 expression in cell line KB differentiated by all-trans retinoic acid or As2 O3]. (PMID: 19489262) Zhao XH … Zhang M (Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 2009) 3 22 60
  5. In situ adenocarcinoma and squamous carcinoma of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13. (PMID: 16949723) Raspollini MR … Taddei GL (European journal of obstetrics, gynecology, and reproductive biology 2007) 3 22 60

Products for KRT13 Gene

Sources for KRT13 Gene

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