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KRT13 Gene

protein-coding   GIFtS: 58
GCID: GC17M039657

Keratin 13

  See KRT13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 131 2     CK132
Cytokeratin 131 2     cytokeratin-132
CK-132 3     Keratin, Type I Cytoskeletal 132
K132 3     keratin-132
keratin1     Cytokeratin-133
Type I Cytoskeletal 131     Keratin-133

External Ids:    HGNC: 64151   Entrez Gene: 38602   Ensembl: ENSG000001714017   OMIM: 1480655   UniProtKB: P136463   

Export aliases for KRT13 gene to outside databases

Previous GC identifers: GC17M039241 GC17P041731 GC17M039565 GC17M040031 GC17M040033 GC17M036910 GC17M035420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT13 Gene:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of
heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal
layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the
autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome
17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT13 Gene:
KRT13 (keratin 13) is a protein-coding gene. Diseases associated with KRT13 include inverted papilloma, and spindle cell sarcoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT13 (Keratin 13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT13 gene promoter:
         PPAR-gamma1   p53   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT13 promoter sequence
   Search Chromatin IP Primers for KRT13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039657:  view genomic region     (about GC identifiers)

Start:
39,657,233 bp from pter      End:
39,661,957 bp from pter
Size:
4,725 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 13  
Size: 458 amino acids; 49588 Da
Subunit: Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: Q53G54 Q6AZK5 Q8N240
Alternative splicing: 3 isoforms:  P13646-1   P13646-2   P13646-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT13: NX_P13646

Explore proteomics data for KRT13 at MOPED

Post-translational modifications: 

  • O-glycosylated; glycans consist of single N-acetylglucosamine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002265.2  NP_705694.2  

    ENSEMBL proteins: 
     ENSP00000246635   ENSP00000336604   ENSP00000468221   ENSP00000466525   ENSP00000466465  
     ENSP00000467833  

    KRT13 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for KRT13

     
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    antibodies-online proteins for KRT13 (11 products) 

     
    antibodies-online peptides for KRT13

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P13646

    ProtoNet protein and cluster: P13646

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for KRT13:
    keratin 13,major acidic keratin,type I,non cornifying mucosal epithelia (buccal,nasal,esophageal,anogenital)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KRT13           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for KRT13:
     Increased S DNA content  Increased cell death HMECs cel  Increased cell size  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KRT13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IDA9714826
    GO:0045111intermediate filament cytoskeleton IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with KRT13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KRT13 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments
    2Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with KRT13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KRT13
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT13
        Cytoskeleton remodeling Keratin filaments


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT13
    Interactions:

        Search GeneGlobe Interaction Network for KRT13

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for KRT13 (P136463 ENSP000002466354) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    KRT7P087293, ENSP000003292434I2D: score=3 STRING: ENSP00000329243
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009314response to radiation IEA--
    GO:0043587tongue morphogenesis IEA--
    GO:0071300cellular response to retinoic acid IEA--

    Find genes that share ontologies with KRT13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT13 (K1C13)

    9 Novoseek inferred chemical compound relationships for KRT13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 48.3 22 19489262 (4), 10664010 (2), 10692107 (2), 15645120 (2) (see all 10)
    squalene 25.2 1 11938760 (1)
    paraffin 24.4 1 10981879 (1)
    troglitazone 20.7 4 15111325 (2)
    7,12-dimethylbenz(a)anthracene 16.4 8 7681292 (3), 9416579 (1)
    titanium 0 3 1708791 (1), 9692810 (1)
    calcium 0 6 10897584 (4), 9714826 (1)
    proline 0 1 7493031 (1)
    vitamin d 0 1 17168675 (1)



    Find genes that share compounds with KRT13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT13 gene (2 alternative transcripts): 
    NM_002274.3  NM_153490.2  

    Unigene Cluster for KRT13:

    Keratin 13
    Hs.654550  [show with all ESTs]
    Unigene Representative Sequence: AK223077
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246635(uc002hwu.1) ENST00000336861(uc002hwv.1 uc010wfr.2 uc010cxo.3 uc021txk.1)
    ENST00000475217 ENST00000468313 ENST00000587544 ENST00000464634 ENST00000590425
    ENST00000587435 ENST00000587118
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      QuantiFast Probe-based Assays in human, mouse, rat KRT13

    Additional mRNA sequence: 

    AK092276.1 AK223051.1 AK223077.1 AK290244.1 AK296806.1 AK309752.1 BC002661.2 BC077718.1 
    BC126184.1 BC136494.1 X14640.1 X52426.1 

    Selected DOTS entries (see all 39):

    DT.91868195  DT.100780331  DT.91696844  DT.446026  DT.100844692  DT.120986358  DT.92330929  DT.95166253 
    DT.97865156  DT.120986432  DT.120985819  DT.97812799  DT.120986368  DT.86841970  DT.95166252  DT.91755977 
    DT.120986123  DT.91751431  DT.100672017  DT.95113223  DT.120986371  DT.91755970  DT.91755980  DT.120986231 

    22 AceView cDNA sequences:

    CR591347 T29509 AU077019 AW664557 BQ352633 BX406266 AA846709 AA378752 
    BF219671 AW265457 BM836499 AW627647 C00438 AW382309 AW627577 AW664317 
    BE181990 AW662177 NM_153490 NM_002274 AW630818 AW630934 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KRT13    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:              -     -                       -                                 
    SP2:              -     -                       -                                 
    SP3:                                                                              
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for KRT13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCGGGGC
    KRT13 Expression
    About this image


    KRT13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Corneal Epithelium
             Limbal epithelial stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Epidermis (Integumentary System)
    KRT13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654550

    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
    Tissue specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus
    and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT13 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt131 , 5 keratin 131, 5 88.19(n)1
    91.89(a)1
      11 (63.41 cM)5
    166631  NM_010662.11  NP_034792.11 
     1001173275 
    chicken
    (Gallus gallus)
    Aves KRT156
    keratin, type I cytoskeletal 15
    64(a)
    1 → many
    27(4541983-4546408)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    6(70623216-70631496)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia krt151 keratin 15 64.68(n)
    64.18(a)
      100379888  XM_002939037.2  XP_002939083.2 


    ENSEMBL Gene Tree for KRT13 (if available)
    TreeFam Gene Tree for KRT13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT13 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  
    KRT262  KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  
    KRT33A2  
    Selected SIMAP similar genes for KRT13 using alignment to 6 protein entries:     K1C13_HUMAN (see all proteins) (see all similar genes):
    GUCA1B    KRT15    JUP    KRT16    keratin    type I hair keratin
    K14    KRT14    KRT20    KRT31    KRT10    KRT33B
    KRT12    KRT33A    KRT24    KRT34    KRT9    KRT40

    Find genes that share paralogs with KRT13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT13 (see all 255)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0160354
    White sponge nevus of Cannon (WSN)4--see VAR_0160352 M T mis40--------
    VAR_0160374
    White sponge nevus of Cannon (WSN)4--see VAR_0160372 L P mis40--------
    VAR_0038364
    White sponge nevus of Cannon (WSN)4--see VAR_0038362 L P mis40--------
    VAR_0160364
    White sponge nevus of Cannon (WSN)4--see VAR_0160362 N S mis40--------
    VAR_0239244
    White sponge nevus of Cannon (WSN)4--see VAR_0239242 L P mis40--------
    rs604403961,2
    Cpathogenic140448982(-) CTACCC/TGGAGA 4 P L mis10--------
    rs588475631,2
    C--35426964(+) CCTGAG/TATGTG 2 -- us2k10--------
    rs1415265501,2
    C--35426965(+) CCTGA-/GATGTG 2 -- us2k10--------
    rs1820655191,2
    --40444268(+) GAGTGC/GATGCC 2 -- ds5001 int10--------
    rs1147570551,2
    F--40444316(+) TCTCTG/ACAGGA 2 -- ds5001 int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for KRT13 (39657233 - 39661957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KRT13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483014CNV Loss15286789
    nsv524606CNV Loss19592680
    nsv510711CNV Loss20534489
    nsv526466CNV Gain19592680
    esv34903CNV Gain17911159
    nsv827992CNV Gain20364138
    nsv9555CNV Gain18304495
    dgv962e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): KRT13
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KRT13
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148065   
    OMIM disorders: 193900  
    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
  • White sponge nevus of Cannon (WSN) [MIM:193900]: Rare autosomal dominant disorder which predominantly
    affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft,
    white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial
    thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less
    frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 18 diseases for KRT13:    
    About MalaCards
    inverted papilloma    spindle cell sarcoma    white sponge nevus of cannon, krt13-related    hereditary mucosal leukokeratosis
    frontal sinus inverted papilloma    cholesteatoma    white sponge nevus 1    papilloma
    limbal stem cell deficiency    lichen planus    middle ear cholesteatoma    leukoplakia
    sweat gland carcinoma    oral lichen planus    oral cancer    tongue cancer
    oral leukoplakia    transitional cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for KRT13:
    Hereditary mucosal leukokeratosis     Frontal sinus inverted papilloma     Carcinoma

    Find genes that share disorders with KRT13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KRT13 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 64.1 15 17725101 (2), 14654899 (1), 9833698 (1), 15645120 (1) (see all 8)
    metaplasia 58.2 6 7531792 (2), 1372155 (1), 16836912 (1), 11193477 (1)
    cholesteatoma middle ear 57.7 1 7510866 (1)
    brenner tumor 55.4 1 11253121 (1)
    oral cancer 50.9 4 14654899 (1), 11098092 (1), 9574953 (1)
    papilloma 44 4 16029072 (1), 7679053 (1), 7542177 (1)
    dysplasia 43.9 6 20036603 (3), 8818688 (2), 1373415 (1)
    carcinoma undifferentiated 43 1 9253034 (1)
    carcinoma 42.6 14 9833698 (3), 1707029 (1), 11787851 (1), 8634660 (1) (see all 8)
    leukoplakia 41.3 5 20036603 (3), 16540085 (2)


    Export disorders for KRT13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT13 gene, integrated from 10 sources (see all 230):
    (articles sorted by number of sources associating them with KRT13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, sequence and expression of the gene encoding human keratin 13. (PubMed id 9714826)1, 2, 9 Waseem A.... Waseem N.H. (Gene 1998)
    2. Identification of two novel mutations in keratin 13 as the cause of white sponge naevus. (PubMed id 10561721)1, 2, 9 Rugg E.L.... Lane E.B. (Oral Dis. 1999)
    3. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. (PubMed id 7493031)1, 2, 9 Richard G.... Compton J.G. (Nat. Genet. 1995)
    4. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Constitutional mutation of keratin 13 gene in familial white sponge nevus. (PubMed id 14600690)1, 2 Shibuya Y.... Komori T. (Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2003)
    9. A novel mutation in the keratin 13 gene causing oral white sponge nevus. (PubMed id 11379896)1, 2 Terrinoni A....McLean W.H.I. (J. Dent. Res. 2001)
    10. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. (PubMed id 2483837)1, 2 Kuruc N.... Franke W.W. (Differentiation 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3860 HGNC: 6415 AceView: KRT13 Ensembl:ENSG00000171401 euGenes: HUgn3860
    ECgene: KRT13 H-InvDB: KRT13

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KRT13 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KRT13[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Keratin_13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT13 gene:
    Search GeneIP for patents involving KRT13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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