Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT13 Gene

protein-coding   GIFtS: 59
GCID: GC17M039657

Keratin 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 131 2     CK132
Cytokeratin 131 2     cytokeratin-132
CK-132 3     Keratin, Type I Cytoskeletal 132
K132 3     keratin-132
keratin1     Cytokeratin-133
Type I Cytoskeletal 131     Keratin-133

External Ids:    HGNC: 64151   Entrez Gene: 38602   Ensembl: ENSG000001714017   OMIM: 1480655   UniProtKB: P136463   

Export aliases for KRT13 gene to outside databases

Previous GC identifers: GC17M039241 GC17P041731 GC17M039565 GC17M040031 GC17M040033 GC17M036910 GC17M035420


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT13 Gene:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and
hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of
heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal
layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the
autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome
17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT13 Gene: 
KRT13 (keratin 13) is a protein-coding gene. Diseases associated with KRT13 include inverted papilloma, and spindle cell sarcoma, and among its related super-pathways are Cytoskeleton remodeling Keratin filaments. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT13 (Keratin 13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT13 gene promoter:
         PPAR-gamma1   p53   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT13 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039657:  view genomic region     (about GC identifiers)

Start:
39,657,233 bp from pter      End:
39,661,957 bp from pter
Size:
4,725 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 13  
Size: 458 amino acids; 49588 Da
Subunit: Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Secondary accessions: Q53G54 Q6AZK5 Q8N240
Alternative splicing: 3 isoforms:  P13646-1   P13646-2   P13646-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT13: NX_P13646

Explore proteomics data for KRT13 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated; glycans consist of single N-acetylglucosamine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13646

  • KRT13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT13 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002265.2  NP_705694.2  

    ENSEMBL proteins: 
     ENSP00000246635   ENSP00000336604   ENSP00000468221   ENSP00000466525   ENSP00000466465  
     ENSP00000467833  

    Human Recombinant Protein Products for KRT13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KRT13
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KRT13
    GenScript Custom Purified and Recombinant Proteins Services for KRT13
    Novus Biologicals KRT13 Proteins
    Novus Biologicals KRT13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IDA9714826
    GO:0070062extracellular vesicular exosome IDA--

    KRT13 for ontologies           About GeneDecksing



    KRT13 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT13
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for KRT13  (K13)
    OriGene Antibodies for KRT13
    OriGene Custom Antibody Services for KRT13
    GenScript Custom Superior Antibodies Services for KRT13
    Novus Biologicals KRT13 Antibodies
    Abcam antibodies for KRT13
    Cloud-Clone Corp. Antibodies for KRT13 
    ThermoFisher Antibody for KRT13
    LSBio Antibodies in human, mouse, rat for KRT13 

    Assay Products for KRT13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KRT13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT13 
    Cloud-Clone Corp. CLIAs for KRT13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF1: Intermediate filaments type I, keratins (acidic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P13646

    ProtoNet protein and cluster: P13646

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
    Similarity: Belongs to the intermediate filament family


    KRT13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for KRT13:
    keratin 13,major acidic keratin,type I,non cornifying mucosal epithelia (buccal,nasal,esophageal,anogenital)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
         
    KRT13 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for KRT13:
     Increased S DNA content  Increased cell death HMECs cel  Increased cell size  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT13 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT13
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT13
    SwitchGear 3'UTR luciferase reporter plasmidKRT13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KRT13
    Sirion Biotech Customized adenovirus for overexpression of KRT13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KRT13 (see all 12)
    OriGene ORF clones in mouse, rat for KRT13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KRT13 (NM_153490)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT13
    Sirion Biotech Customized lentivirus for stable overexpression of KRT13 
                         Customized lentivirus expression plasmids for stable overexpression of KRT13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KRT13
    Search LifeMap BioReagents cell lines for KRT13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KRT13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91
    2Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KRT13
        Cytoskeleton remodeling Keratin filaments


    1 Cell Signaling Technology (CST) Pathway for KRT13
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT13
        Cytoskeleton remodeling Keratin filaments



    KRT13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT13

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/59 Interacting proteins for KRT13 (P136463 ENSP000002466354) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    KRT7P087293, ENSP000003292434I2D: score=3 STRING: ENSP00000329243
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS7493031
    GO:0009314response to radiation IEA--
    GO:0043587tongue morphogenesis IEA--
    GO:0071300cellular response to retinoic acid IEA--

    KRT13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT13 (K1C13)

    9 Novoseek inferred chemical compound relationships for KRT13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 48.3 22 19489262 (4), 10664010 (2), 10692107 (2), 15645120 (2) (see all 10)
    squalene 25.2 1 11938760 (1)
    paraffin 24.4 1 10981879 (1)
    troglitazone 20.7 4 15111325 (2)
    7,12-dimethylbenz(a)anthracene 16.4 8 7681292 (3), 9416579 (1)
    titanium 0 3 1708791 (1), 9692810 (1)
    calcium 0 6 10897584 (4), 9714826 (1)
    proline 0 1 7493031 (1)
    vitamin d 0 1 17168675 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT13 / K1C13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT13 gene (2 alternative transcripts): 
    NM_002274.3  NM_153490.2  

    Unigene Cluster for KRT13:

    Keratin 13
    Hs.654550  [show with all ESTs]
    Unigene Representative Sequence: AK223077
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246635(uc002hwu.1) ENST00000336861(uc002hwv.1 uc010wfr.2 uc010cxo.3 uc021txk.1)
    ENST00000475217 ENST00000468313 ENST00000587544 ENST00000464634 ENST00000590425
    ENST00000587435 ENST00000587118
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT13
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT13
    SwitchGear 3'UTR luciferase reporter plasmidKRT13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT13
    Clone
    Products:
         
    OriGene clones in human, mouse for KRT13 (see all 12)
    OriGene ORF clones in mouse, rat for KRT13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KRT13 (NM_153490)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT13
    Sirion Biotech Customized lentivirus for stable overexpression of KRT13 
                         Customized lentivirus expression plasmids for stable overexpression of KRT13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT13

    Additional mRNA sequence: 

    AK092276.1 AK223051.1 AK223077.1 AK290244.1 AK296806.1 AK309752.1 BC002661.2 BC077718.1 
    BC126184.1 BC136494.1 X14640.1 X52426.1 

    24/39 DOTS entries (see all 39):

    DT.91868195  DT.100780331  DT.91696844  DT.446026  DT.100844692  DT.120986358  DT.92330929  DT.95166253 
    DT.97865156  DT.120986432  DT.120985819  DT.97812799  DT.120986368  DT.86841970  DT.95166252  DT.91755977 
    DT.120986123  DT.91751431  DT.100672017  DT.95113223  DT.120986371  DT.91755970  DT.91755980  DT.120986231 

    22 AceView cDNA sequences:

    AW627647 AU077019 BX406266 CR591347 T29509 AA378752 AW265457 C00438 
    AW627577 BE181990 AW662177 AW664317 BM836499 BF219671 AA846709 AW664557 
    BQ352633 AW382309 NM_153490 NM_002274 AW630818 AW630934 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KRT13    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:              -     -                       -                                 
    SP2:              -     -                       -                                 
    SP3:                                                                              
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for KRT13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT13 expression in normal human tissues (normalized intensities)      KRT13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCGGGGC
    KRT13 Expression
    About this image


    KRT13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 6 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             oral mucosa ; squamous epithelial cells   
             Tongue   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
             Trachea   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             urinary bladder ; urothelial cells   
             visceral organ/urethra of male   

    See KRT13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT13

    SOURCE GeneReport for Unigene cluster: Hs.654550

    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
    Tissue specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus
    and placenta

        SABiosciences Custom PCR Arrays for KRT13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT13 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt131 , 5 keratin 131, 5 86.25(n)1
    88.34(a)1
      11 (63.41 cM)5
    166631  NM_010662.11  NP_034792.11 
     1001173275 
    chicken
    (Gallus gallus)
    Aves KRT156
    keratin, type I cytoskeletal 15
    63(a)
    1 → many
    27(4541983-4546408)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    66(a)
    1 → many
    6(70623216-70631496)


    ENSEMBL Gene Tree for KRT13 (if available)
    TreeFam Gene Tree for KRT13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT13 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT372  
    KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  KRT262  
    KRT102  KRT122  KRT352  KRT152  KRT242  KRT92  KRT33B2  KRT33A2  
    18/62 SIMAP similar genes for KRT13 using alignment to 6 protein entries:     K1C13_HUMAN (see all proteins) (see all similar genes):
    GUCA1B    KRT15    JUP    KRT16    keratin    type I hair keratin
    K14    KRT14    KRT20    KRT31    KRT10    KRT33B
    KRT12    KRT33A    KRT24    KRT34    KRT9    KRT40

    KRT13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/255 SNPs in KRT13 are shown (see all 255)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0160354
    White sponge nevus of cannon (WSN)4--see VAR_0160352 M T mis40--------
    VAR_0160374
    White sponge nevus of cannon (WSN)4--see VAR_0160372 L P mis40--------
    VAR_0038364
    White sponge nevus of cannon (WSN)4--see VAR_0038362 L P mis40--------
    VAR_0160364
    White sponge nevus of cannon (WSN)4--see VAR_0160362 N S mis40--------
    VAR_0239244
    White sponge nevus of cannon (WSN)4--see VAR_0239242 L P mis40--------
    rs604403961,2
    Cpathogenic140448982(-) CTACCC/TGGAGA 4 P L mis10--------
    VAR_0593774
    ----see VAR_0593772 T A mis40--------
    rs588475631,2
    C--35426964(+) CCTGAG/TATGTG 2 -- us2k10--------
    rs1415265501,2
    C--35426965(+) CCTGA-/GATGTG 2 -- us2k10--------
    rs1820655191,2
    --40444268(+) GAGTGC/GATGCC 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for KRT13 (39657233 - 39661957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KRT13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483014CNV Loss15286789
    nsv524606CNV Loss19592680
    nsv510711CNV Loss20534489
    nsv526466CNV Gain19592680
    esv34903CNV Gain17911159
    nsv827992CNV Gain20364138
    nsv9555CNV Gain18304495
    dgv962e1CNV Complex17122850
    dgv961e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): KRT13
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KRT13
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148065   
    OMIM disorders: 193900  
    UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646
  • White sponge nevus of cannon (WSN) [MIM:193900]: Rare autosomal dominant disorder which predominantly
    affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft,
    white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial
    thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less
    frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 20/46 diseases for KRT13 (see all 46):    About MalaCards
    inverted papilloma    spindle cell sarcoma    white sponge nevus of cannon, krt13-related    hereditary mucosal leukokeratosis
    frontal sinus inverted papilloma    cholesteatoma    middle ear cholesteatoma    sweat gland carcinoma
    limbal stem cell deficiency    vaginal cancer    papilloma    lichen planus
    oral lichen planus    vaginitis    transitional cell carcinoma    t cell deficiency
    oral cancer    tongue cancer    adenosquamous carcinoma    benign tumors

    3 diseases from the University of Copenhagen DISEASES database for KRT13:
    Hereditary mucosal leukokeratosis     Frontal sinus inverted papilloma     Carcinoma

    KRT13 for disorders           About GeneDecksing

    10/38 Novoseek inferred disease relationships for KRT13 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 64.1 15 17725101 (2), 14654899 (1), 9833698 (1), 15645120 (1) (see all 8)
    metaplasia 58.2 6 7531792 (2), 1372155 (1), 16836912 (1), 11193477 (1)
    cholesteatoma middle ear 57.7 1 7510866 (1)
    brenner tumor 55.4 1 11253121 (1)
    oral cancer 50.9 4 14654899 (1), 11098092 (1), 9574953 (1)
    papilloma 44 4 16029072 (1), 7679053 (1), 7542177 (1)
    dysplasia 43.9 6 20036603 (3), 8818688 (2), 1373415 (1)
    carcinoma undifferentiated 43 1 9253034 (1)
    carcinoma 42.6 14 9833698 (3), 1707029 (1), 11787851 (1), 8634660 (1) (see all 8)
    leukoplakia 41.3 5 20036603 (3), 16540085 (2)


    Export disorders for KRT13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT13 gene, integrated from 9 sources (see all 228):
    (articles sorted by number of sources associating them with KRT13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, sequence and expression of the gene encoding human keratin 13. (PubMed id 9714826)1, 2, 9 Waseem A.... Waseem N.H. (1998)
    2. Identification of two novel mutations in keratin 13 as the cause of white sponge naevus. (PubMed id 10561721)1, 2, 9 Rugg E.L.... Lane E.B. (1999)
    3. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. (PubMed id 7493031)1, 2, 9 Richard G.... Compton J.G. (1995)
    4. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Constitutional mutation of keratin 13 gene in familial white sponge nevus. (PubMed id 14600690)1, 2 Shibuya Y.... Komori T. (2003)
    9. A novel mutation in the keratin 13 gene causing oral white sponge nevus. (PubMed id 11379896)1, 2 Terrinoni A....McLean W.H.I. (2001)
    10. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. (PubMed id 2483837)1, 2 Kuruc N.... Franke W.W. (1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3860 HGNC: 6415 AceView: KRT13 Ensembl:ENSG00000171401 euGenes: HUgn3860
    ECgene: KRT13 H-InvDB: KRT13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT13 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT13
    Wikipedia http://en.wikipedia.org/wiki/Keratin_13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT13 gene:
    Search GeneIP for patents involving KRT13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT13
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KRT13   OriGene RNAi products in human, mouse, rat for KRT13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KRT13  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KRT13  
     OriGene qSTAR qPCR primer pairs in human, mouse for KRT13   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KRT13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT13   OriGene Custom Protein Services for KRT13  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT13
     QIAGEN SeqTarget long-range PCR primers for resequencing KRT13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT13
     GenScript Custom Purified and Recombinant Proteins Services for KRT13 GenScript cDNA clones with any tag delivered in your preferred vector for KRT13
     GenScript Custom Assay Services for KRT13 GenScript Custom Superior Antibodies Services for KRT13
     GenScript Custom overexpressing Cell Line Services for KRT13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for KRT13  (K13)

     Regulatory tfbs in KRT13 promoter
     Search Chromatin IP Primers for KRT13
     RT2 qPCR Primer Assay in human, mouse, rat KRT13
     Search GNC Networks for KRT13
     SABiosciences Custom PCR Arrays for KRT13
     Search Tocris compounds for KRT13 (K1C13)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KRT13 antibodies
     KRT13 proteins
     KRT13 lysates
     Antibodies for KRT13
     See all of Abcam's Antibodies, Kits and Proteins for KRT13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KRT13
     Antibodies for KRT13
     ELISAs for KRT13
     CLIAs for KRT13
     Search LifeMap BioReagents cell lines for KRT13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13
     SwitchGear 3'UTR luciferase reporter plasmids for KRT13
     SwitchGear Promoter luciferase reporter plasmids for KRT13
     ThermoFisher Antibody for KRT13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT13
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT13
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT13
    Customized:
     lentivirus for stable overexpression of KRT13
     lentivirus expression plasmids for stable overexpression of KRT13
     adenovirus for overexpression of KRT13
     LSBio Antibodies in human, mouse, rat for KRT13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KRT13 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4