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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT13 Gene

protein-coding GIFtS: 60
GCID: GC17M039657

keratin 13

Explore 52 diseases affiliated with
KRT13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 13¹ ²		Cytokeratin 13²
K13¹ ² ³		Cytokeratin-13³
CK13¹ ²		Keratin, Type I Cytoskeletal 13²
CK-13² ³		Keratin-13³
MGC161462¹		Cytokeratin-13³
MGC3781¹		Keratin-13³

External Ids:	HGNC: 6415¹	Entrez Gene: 3860²	Ensembl: ENSG00000171401⁷	OMIM: 148065⁵	UniProtKB: P13646³

Export aliases for KRT13 gene to outside databases

Previous GC identifers: GC17M039241 GC17P041731 GC17M039565 GC17M040031 GC17M040033 GC17M036910 GC17M035420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT13:

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament

proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair

keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic

keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of

non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal

dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2.

Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been

described. (provided by RefSeq, Jul 2008)

Gene Wiki entry for KRT13 (Keratin 13)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT13 gene promoter:
PPAR-gamma1 p53 PPAR-gamma2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT13 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21-q23

KRT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT13 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M039657: view genomic region (about GC identifiers)

Start:	39,657,233 bp from pter	End:	39,661,957 bp from pter
Size:	4,725 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646 (See protein sequence)

Recommended Name: Keratin, type I cytoskeletal 13

Size: 458 amino acids; 49588 Da

Subunit: Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to

basic; 56-70 kDa)

Secondary accessions: Q53G54 Q6AZK5 Q8N240

Alternative splicing: 3 isoforms: P13646-1 P13646-2 P13646-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT13: NX_P13646

Post-translational modifications:

O-glycosylated; glycans consist of single N-acetylglucosamine residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13646

KRT13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002265.2 NP_705694.2

ENSEMBL proteins:

ENSP00000246635 ENSP00000336604 ENSP00000468221 ENSP00000466525 ENSP00000466465

ENSP00000467833

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KRT13

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045095	keratin filament	IDA	9714826
GO:0070062	extracellular vesicular exosome	IDA	--

KRT13 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KRT13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT13 for domains About GeneDecksing

4 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR016044 F

Graphical View of Domain Structure for InterPro Entry P13646

ProtoNet protein and cluster: P13646

2 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for KRT13:

keratin 13,major acidic keratin,type I,non cornifying mucosal epithelia (buccal,nasal,esophageal,anogenital)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KRT13 Browse MicroRNA Expression Plasmids
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KRT13
		Search LifeMap BioReagents cell lines for KRT13

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	--	--

KRT13 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for KRT13:

Increased S DNA content

Increased cell death HMECs cel

Increased cell size

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Keratin filaments

Cytoskeleton remodeling Keratin filaments

1.00

Cytoskeleton remodeling_Keratin filaments

0.91

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KRT13

Cytoskeleton remodeling Keratin filaments

1 Cell Signaling Technology (CST) Pathway for KRT13

Cytoskeletal Signaling

1 GeneGo (Thomson Reuters) Pathway for KRT13

Cytoskeleton remodeling Keratin filaments

KRT13 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KRT13

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/59 Interacting proteins for KRT13 (P13646³ ENSP00000246635⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APC	P25054³, ENSP00000257430⁴	I2D: score=3 STRING: ENSP00000257430
KRT7	P08729³, ENSP00000329243⁴	I2D: score=3 STRING: ENSP00000329243
MAP1LC3B	Q9GZQ8³, ENSP00000268607⁴	I2D: score=2 STRING: ENSP00000268607
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
GABARAP	O95166³	I2D: score=2

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008544	epidermis development	TAS	7493031
GO:0009314	response to radiation	IEA	--
GO:0043587	tongue morphogenesis	IEA	--
GO:0071300	cellular response to retinoic acid	IEA	--

KRT13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KRT13 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT13
9 Novoseek chemical compound relationships for KRT13 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	48.3	22	19489262 (4), 10664010 (2), 10692107 (2), 15645120 (2) (see all 10)
squalene	25.2	1	11938760 (1)
paraffin	24.4	1	10981879 (1)
troglitazone	20.7	4	15111325 (2)
7,12-dimethylbenz(a)anthracene	16.4	8	7681292 (3), 9416579 (1)
titanium	0	3	1708791 (1), 9692810 (1)
calcium	0	6	10897584 (4), 9714826 (1)
proline	0	1	7493031 (1)
vitamin d	0	1	17168675 (1)

Search CenterWatch for drugs/clinical trials and news about KRT13 / K1C13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRT13 gene (2 alternative transcripts):

NM_002274.3 NM_153490.2

Unigene Cluster for KRT13:

Keratin 13

Hs.654550 [show with all ESTs]

Unigene Representative Sequence: AK223077

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000246635(uc002hwu.1) ENST00000336861(uc002hwv.1 uc010wfr.2 uc010cxo.3 uc021txk.1)

ENST00000475217 ENST00000468313 ENST00000587544 ENST00000464634 ENST00000590425

ENST00000587435 ENST00000587118

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KRT13 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT13
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT13

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT13 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT13 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT13

Additional cDNA sequence:

AK092276.1 AK223051.1 AK223077.1 AK290244.1 AK296806.1 AK309752.1 BC002661.2 BC077718.1

BC126184.1 BC136494.1 X14640.1 X52426.1

24/39 DOTS entries (see all 39):

DT.91868195 DT.100780331 DT.91696844 DT.446026 DT.100844692 DT.120986358 DT.92330929 DT.95166253

DT.97865156 DT.120986432 DT.120985819 DT.97812799 DT.120986368 DT.86841970 DT.95166252 DT.91755977

DT.120986123 DT.91751431 DT.100672017 DT.95113223 DT.120986371 DT.91755970 DT.91755980 DT.120986231

22 AceView cDNA sequences:

BM836499 AW662177 AW382309 AW627577 BX406266 AW627647 BE181990 BF219671

T29509 BQ352633 AU077019 AW265457 AA378752 C00438 AA846709 CR591347

AW664317 AW664557 NM_153490 NM_002274 AW630818 AW630934

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KRT13 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9
SP1:					-		-								-
SP2:					-		-								-
SP3:
SP4:							-
SP5:

ECgene alternative splicing isoforms for KRT13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCGGGGC

About this image

KRT13 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Alveolar type II cells (Derivation of mature...)

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KRT13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT13

SOURCE GeneReport for Unigene cluster: Hs.654550

UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646

Tissue specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and

placenta

SABiosciences Custom PCR Arrays for KRT13

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KRT13 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NDN5_CHICK⁶	keratin 15	62(a)	1 → many	27(4195253-4199633)
zebrafish (Danio rerio)	Actinopterygii	si:rp71-1n18.1⁶ cyt1l⁶ (see all 15)	type I cytokeratin, enveloping layer, like (see all 15)	50(a) 50(a) (see all 15)	many ↔ many many ↔ many (see all 15)	22(11885419-11889710) 19(5980624-5982658)

ENSEMBL Gene Tree for KRT13 (if available)
TreeFam Gene Tree for KRT13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT13 gene

KRT17² KRT16² KRT26² KRT10² KRT12² KRT18² KRT25² KRT15²

KRT20² KRT27² KRT24² KRT19² KRT9² KRT28² KRT14² KRT23²

18/62 SIMAP similar genes for KRT13 using alignment to 6 protein entries: K1C13_HUMAN (see all proteins) (see all similar genes):

GUCA1B KRT15 JUP KRT16 keratin type I hair keratin

K14 KRT14 KRT20 KRT31 KRT10 KRT33B

KRT12 KRT33A KRT24 KRT34 KRT9 KRT40

KRT13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60440396^1,2	C	pathogenic	35680647(-)	`CTACCC/TGGAGA`	4	P L	mis¹		0	--	--	--	--
rs76221682^1,2	F,	--	35420812(+)	`CCAGGG/TCCCTA`	2	--	ds500¹ int¹		1		EA	120
rs72832098^1,2		--	35420813(+)	`CAGGGC/GCCTAG`	2	--	int¹ ds500¹		0	--	--	--	--
rs1031^1,2	F,H	--	35420973(-)	`CTCTGT/GGCTCT`	2	--	ut3¹		6		MN NS EA	614
rs11550071^1,2	C	--	35420997(+)	`GAGAGA/GGTCAG`	2	--	ut3¹ ese³		2		NA	4
rs79846820^1,2		--	35421788(+)	`ACTGGC/GACTGT`	2	--	int¹		0	--	--	--	--
rs12603751^1,2	C,F,H	--	35422833(+)	`CCTCAG/ACATCC`	4	/A /V	mis¹ ese³		8		NS EA NA	684
rs61092365^1,2	F,	--	35423724(+)	`TAGCTG/AATGGG`	2	--	int¹		3		WA NA EA	358
rs77879418^1,2	F,	--	35423871(+)	`TCTGGG/TGGGTC`	2	--	int¹		1		WA	118
rs76318578^1,2	F,	--	35424317(+)	`TAAACG/ATTTAT`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for KRT13 (39657233 - 39661957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for KRT13
5 CNVs: 0205 3145 30831 8845 4036
Human Gene Mutation Database (HGMD): KRT13

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT13

DNA2.0 Custom Variant and Variant Library Synthesis for KRT13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT13 for disorders           About GeneDecksing

OMIM gene information: 148065
OMIM disorders: 193900
UniProtKB/Swiss-Prot: K1C13_HUMAN, P13646

Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal

dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is

characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic

histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral

epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are

involved

20/52 diseases for KRT13 (see all 52): About MalaCards

nevus hereditary mucosal leukokeratosis middle ear cholesteatoma lichen planus

inverted papilloma sweat gland carcinoma oral lichen planus primitive neuroectodermal tumor

squamous cell carcinoma cholesteatoma bladder transitional cell carcinoma spindle cell sarcoma

transitional cell carcinoma papilloma laryngeal squamous cell carcinoma neuroectodermal tumors

intraepithelial neoplasm oral squamous cell carcinoma squamous cell carcinoma of the head and neck cystic fibrosis

3 diseases from the University of Copenhagen DISEASES database for KRT13:

Hereditary mucosal leukokeratosis Frontal sinus inverted papilloma Carcinoma

10/38 Novoseek disease relationships for KRT13 gene (see all 38) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	64.1	15	17725101 (2), 14654899 (1), 9833698 (1), 15645120 (1) (see all 8)
metaplasia	58.2	6	7531792 (2), 1372155 (1), 16836912 (1), 11193477 (1)
cholesteatoma middle ear	57.7	1	7510866 (1)
brenner tumor	55.4	1	11253121 (1)
oral cancer	50.9	4	14654899 (1), 11098092 (1), 9574953 (1)
papilloma	44	4	16029072 (1), 7679053 (1), 7542177 (1)
dysplasia	43.9	6	20036603 (3), 8818688 (2), 1373415 (1)
carcinoma undifferentiated	43	1	9253034 (1)
carcinoma	42.6	14	9833698 (3), 1707029 (1), 11787851 (1), 8634660 (1) (see all 8)
leukoplakia	41.3	5	20036603 (3), 16540085 (2)

Export disorders for KRT13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRT13 gene, integrated from 9 sources (see all 225):
(articles sorted by number of sources associating them with KRT13)

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Isolation, sequence and expression of the gene encoding human keratin 13. (PubMed id 9714826)^{1, 2, 9} Waseem A.... Waseem N.H. (1998)
Identification of two novel mutations in keratin 13 as the cause of white sponge naevus. (PubMed id 10561721)^{1, 2, 9} Rugg E.L.... Lane E.B. (1999)
Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. (PubMed id 7493031)^{1, 2, 9} Richard G.... Compton J.G. (1995)
New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 3} Schweizer J....Wright M.W. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Constitutional mutation of keratin 13 gene in familial white sponge nevus. (PubMed id 14600690)^{1, 2} Shibuya Y.... Komori T. (2003)
A novel mutation in the keratin 13 gene causing oral white sponge nevus. (PubMed id 11379896)^{1, 2} Terrinoni A....McLean W.H.I. (2001)
Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. (PubMed id 2483837)^{1, 2} Kuruc N.... Franke W.W. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3860	HGNC: 6415	AceView: KRT13	Ensembl:ENSG00000171401	euGenes: HUgn3860
ECgene: KRT13	H-InvDB: KRT13

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT13	Pharmacogenomics, SNPs, Pathways
Human Intermediate Filament Mutation Database	http://www.interfil.org
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT13
Wikipedia	http://en.wikipedia.org/wiki/Keratin_13

Intellectual Property for KRT13 gene
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Patent Information for KRT13 gene:
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keratin 13

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