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Aliases for KRT10 Gene

Aliases for KRT10 Gene

  • Keratin 10 2 3 5
  • Keratin 10, Type I 2 3
  • Cytokeratin 10 2 3
  • CK-10 3 4
  • KPP 3 4
  • K10 3 4
  • Keratosis Palmaris Et Plantaris 2
  • Keratin, Type I Cytoskeletal 10 3
  • Epidermolytic Hyperkeratosis 2
  • Cytokeratin-10 4
  • Keratin-10 4
  • BCIE 3
  • CK10 3
  • EHK 3
  • BIE 3

External Ids for KRT10 Gene

Previous HGNC Symbols for KRT10 Gene

  • KPP

Previous GeneCards Identifiers for KRT10 Gene

  • GC17M038474
  • GC17M041150
  • GC17M038763
  • GC17M039347
  • GC17M036227
  • GC17M038974
  • GC17M034768

Summaries for KRT10 Gene

Entrez Gene Summary for KRT10 Gene

  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT10 Gene

KRT10 (Keratin 10) is a Protein Coding gene. Diseases associated with KRT10 include Epidermolytic Hyperkeratosis and Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis. Among its related pathways are Keratinization and Staphylococcus aureus infection. GO annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT14.

Gene Wiki entry for KRT10 Gene

Additional gene information for KRT10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT10 Gene

Genomics for KRT10 Gene

Regulatory Elements for KRT10 Gene

Enhancers for KRT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H040846 0.6 FANTOM5 16.5 -24.3 -24345 0.1 SCRT1 MAX CEBPB RFX5 POLR2A SCRT2 ZSCAN5C STAT3 TMEM99 KRT10 KRT28 KRT27 KRT26 ENSG00000234477 KRT222 SMARCE1 KRTAP2-1 LOC105371777
GH17H040825 0.7 ENCODE 0.7 -3.5 -3549 0.9 STAT1 JUN ZSCAN4 CEBPB EP300 ZNF592 ZNF664 NFIC ZNF366 IKZF1 TMEM99 KRT27 KRT23 MED24 KRT10 PIR60311
GH17H040827 1.1 ENCODE 0.4 -6.0 -5963 2.9 PKNOX1 ARNT FEZF1 ZNF2 ZNF766 REST SMARCB1 ZNF592 MEF2D ZNF610 P3H4 KRT27 KRT23 MED24 PIR60311 KRT10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT10 Gene

Genomic Locations for KRT10 Gene
4,502 bases
Minus strand

Genomic View for KRT10 Gene

Genes around KRT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT10 Gene

Proteins for KRT10 Gene

  • Protein details for KRT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 10
    Protein Accession:
    Secondary Accessions:
    • Q14664
    • Q8N175

    Protein attributes for KRT10 Gene

    584 amino acids
    Molecular mass:
    58827 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    • Sequence=AAA59468.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KRT10 Gene

neXtProt entry for KRT10 Gene

Post-translational modifications for KRT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT10 Gene

Domains & Families for KRT10 Gene

Gene Families for KRT10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT10: view

Function for KRT10 Gene

Molecular function for KRT10 Gene

GENATLAS Biochemistry:
keratin 10,type I,suprabasal (spinous) layer,dimerizing with KRT1,also with KRT9

Gene Ontology (GO) - Molecular Function for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0030280 structural constituent of epidermis NAS,IDA 2459124
genes like me logo Genes that share ontologies with KRT10: view
genes like me logo Genes that share phenotypes with KRT10: view

Human Phenotype Ontology for KRT10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT10 Gene

Localization for KRT10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 7543090
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 22170488
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KRT10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT10 Gene

Pathways & Interactions for KRT10 Gene

genes like me logo Genes that share pathways with KRT10: view

Pathways by source for KRT10 Gene

1 Cell Signaling Technology pathway for KRT10 Gene
2 Reactome pathways for KRT10 Gene
1 KEGG pathway for KRT10 Gene

Gene Ontology (GO) - Biological Process for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IDA 7543090
GO:0030216 keratinocyte differentiation IEP 22170488
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
GO:0098773 skin epidermis development IC 7543090
genes like me logo Genes that share ontologies with KRT10: view

No data available for SIGNOR curated interactions for KRT10 Gene

Drugs & Compounds for KRT10 Gene

(22) Drugs for KRT10 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma Target 188
Zinc Approved Pharma Target 2359

(18) Additional Compounds for KRT10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT10: view

Transcripts for KRT10 Gene

mRNA/cDNA for KRT10 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(283) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT10 Gene

Keratin 10:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT10 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for KRT10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT10 Gene

mRNA differential expression in normal tissues according to GTEx for KRT10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x27.4) and Skin - Not Sun Exposed (Suprapubic) (x21.5).

Protein differential expression in normal tissues from HIPED for KRT10 Gene

This gene is overexpressed in Cerebrospinal fluid (16.1) and Bone marrow mesenchymal stem cell (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT10 Gene

Protein tissue co-expression partners for KRT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT10 Gene:


SOURCE GeneReport for Unigene cluster for KRT10 Gene:


mRNA Expression by UniProt/SwissProt for KRT10 Gene:

Tissue specificity: Seen in all suprabasal cell layers including stratum corneum.

Evidence on tissue expression from TISSUES for KRT10 Gene

  • Skin(5)
  • Liver(4.7)
  • Muscle(3.3)
  • Stomach(2.8)
  • Nervous system(2.8)
  • Intestine(2.6)
  • Heart(2.5)
  • Blood(2.4)
  • Kidney(2.3)
  • Eye(2.1)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT10 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • foot
  • hand
  • lower limb
  • upper limb
  • blood
  • blood vessel
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with KRT10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRT10 Gene

Orthologs for KRT10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT10 34
  • 98 (a)
(Canis familiaris)
Mammalia KRT10 34
  • 89 (a)
(Bos Taurus)
Mammalia KRT10 34
  • 88 (a)
(Mus musculus)
Mammalia Krt10 34
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 77 (a)
-- 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia KRT10 34
  • 75 (a)
Species where no ortholog for KRT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT10 Gene

Gene Tree for KRT10 (if available)
Gene Tree for KRT10 (if available)

Paralogs for KRT10 Gene

Variants for KRT10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KRT10 Gene

A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).

Sequence variations from dbSNP and Humsavar for KRT10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs267607383 untested, Epidermolytic hyperkeratosis (EHK) [MIM:113800] 40,819,544(-) AACCT(A/G)CCGCA intron-variant, reference, missense
rs57784225 Pathogenic, Epidermolytic hyperkeratosis (EHK) [MIM:113800] 40,822,126(-) ATCTG(A/C)ATGAC intron-variant, reference, missense
rs58026994 Pathogenic, Epidermolytic hyperkeratosis (EHK) [MIM:113800] 40,819,565(-) CCGAC(A/T)GGAGA intron-variant, reference, missense
rs58075662 Pathogenic, Epidermolytic hyperkeratosis (EHK) [MIM:113800], Epidermolytic hyperkeratosis (EHK) [MIM:113800] 40,822,119(-) TGACC(A/C/G/T)CCTGG intron-variant, reference, missense
rs58414354 Pathogenic, Epidermolytic hyperkeratosis (EHK) [MIM:113800] 40,822,108(-) CTTCC(G/T)ACTTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT10 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT10 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for KRT10 Gene

MalaCards: The human disease database

(55) MalaCards diseases for KRT10 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermolytic hyperkeratosis
  • bullous congenital ichthyosiform erythroderma
ichthyosis, cyclic, with epidermolytic hyperkeratosis
  • annular epidermolytic ichthyosis
ichthyosis with confetti
  • congenital reticular ichthyosiform erythroderma
krt10-related epidermolytic hyperkeratosis
  • krt10-related bullous congenital ichthyosiform erythroderma
  • congenital cholesteatoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT10 in MalaCards View complete list of genes associated with diseases


  • Epidermolytic hyperkeratosis (EHK) [MIM:113800]: An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop. {ECO:0000269 PubMed:10201536, ECO:0000269 PubMed:1380725, ECO:0000269 PubMed:1381287, ECO:0000269 PubMed:21271994, ECO:0000269 PubMed:7507150, ECO:0000269 PubMed:7507152, ECO:0000269 PubMed:7508181, ECO:0000269 PubMed:7512983, ECO:0000269 PubMed:7526210, ECO:0000269 Ref.7}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Erythroderma, ichthyosiform, congenital reticular (CRIE) [MIM:609165]: A rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis. {ECO:0000269 PubMed:20798280}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ichthyosis annular epidermolytic (AEI) [MIM:607602]: A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months. {ECO:0000269 PubMed:9036939, ECO:0000269 PubMed:9856845}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT10: view

No data available for Genatlas for KRT10 Gene

Publications for KRT10 Gene

  1. A novel substitution in keratin 10 in epidermolytic hyperkeratosis. (PMID: 10201536) Arin MJ … Roop DR (The Journal of investigative dermatology 1999) 3 4 22 60
  2. A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma. (PMID: 9856845) Suga Y … Roop DR (The Journal of investigative dermatology 1998) 3 4 22 60
  3. A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma. (PMID: 9036939) Joh GY … Roop DR (The Journal of investigative dermatology 1997) 3 4 22 60
  4. Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. (PMID: 7507150) Rothnagel JA … Roop DR (The Journal of investigative dermatology 1994) 3 4 22 60
  5. Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis. (PMID: 7508181) Chipev CC … Bale SJ (American journal of human genetics 1994) 3 4 22 60

Products for KRT10 Gene

Sources for KRT10 Gene

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