KRT10 Gene
protein-coding GIFtS: 60
GCID: GC17M038974
|
|
keratin 10(Previous name: keratosis palmaris et plantaris )
(Previous symbol: KPP)
| |
Aliases
for KRT10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 101 2 | | EHK2 5 | | K101 2 3 | | Keratosis Palmaris Et Plantaris1 | | KPP1 2 3 | | Cytokeratin 102 | | CK101 2 | | Keratin, Type I Cytoskeletal 102 | | CK-102 3 | | Keratin-103 | | BCIE2 5 | | Cytokeratin-103 | | BIE2 5 | | Keratin-103 |
Export aliases for KRT10 gene to outside databasesPrevious GC identifers: GC17M038474 GC17M041150 GC17M038763 GC17M039347 GC17M036227 GC17M034768 |
Summaries
for KRT10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT10:
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediatefilament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. Thesefilaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutationsin this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin familymembers on chromosome 17q21. (provided by RefSeq, Jul 2008)
Gene Wiki entry for KRT10 (Keratin 10)
|
Genomic Views
for KRT10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT10 gene promoter:
Bach1 C/EBPbeta AML1a NRSF form 1 MyoD LUN-1 STAT5A NRSF form 2 Chx10
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21-q23KRT10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M038974: view genomic region
(about GC identifiers)
Start:
|
38,974,369 bp from pter |
End:
|
38,978,863 bp from pter |
Size:
|
4,495 bases |
Orientation:
|
minus strand |
|
Proteins
for KRT10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K1C10_HUMAN, P13645 (See
protein sequence)Recommended Name: Keratin, type I cytoskeletal 10 Size: 584 amino acids; 58827 Da
Subunit: Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)
Sequence caution: Sequence=AAA59468.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for KRT10:3ASW (3D)
4F1Z (3D)
Secondary accessions: Q14664 Q8N175Explore the universe of human proteins at neXtProt for KRT10: NX_P13645
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13645
KRT10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000412.3
ENSEMBL proteins: ENSP00000269576
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KRT10 for ontologies About GeneDecksing
KRT10 Antibody Products:
Assay Products for KRT10: |
Protein
Domains /
Families
for KRT10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13645ProtoNet protein and cluster: P13645 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1C10_HUMAN, P13645Similarity: Belongs to the intermediate filament family |
Function
for KRT10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for KRT10:keratin 10,type I,suprabasal (spinous) layer,dimerizing with KRT1,also with KRT9
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KRT10 (NM_000421) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT10 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KRT10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT10:
Animal Models:
Mouse knock-outs for KRT10: Krt10tm1Tmm Krt10tm2Tmm
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Krt10):
KRT10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KRT10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Staphylococcus aureus infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for KRT10
1 
Kegg Pathway (Kegg details for KRT10):
KRT10 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/90 Interacting proteins for KRT10 (P136452, 3 ENSP000002695764) via UniProtKB, MINT, STRING, and/or I2D (see all 90)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
KRT10 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KRT10 for compounds About GeneDecksing
 Browse Tocris compounds for KRT10
10/38 Novoseek chemical compound relationships for KRT10 gene (see all 38) About this table
Search CenterWatch for drugs/clinical trials and news about KRT10 / K1C10
|
Transcripts
for KRT10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT10 gene: NM_000421.3 Unigene Cluster for KRT10: Keratin 10 Hs.99936 [show with all ESTs]Unigene Representative Sequence: NM_0004211 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000269576(uc002hvi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT10 (NM_000421) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT10 |
Additional cDNA sequence: BC034697.1 M19156.1 M77663.1 14 DOTS entries: DT.316357 DT.100766186 DT.100766184 DT.92436398 DT.100766188 DT.120921001 DT.120920992 DT.92436399 DT.95323957 DT.100766185 DT.120920985 DT.120920986 DT.91724819 DT.95162150 24/283 AceView cDNA sequences (see all 283): CB111984 CB112034 CB112025 AI076688 CB112047 BM707179 CB112009 NM_000421 CB112029 BG680753 BU727731 BG742191 BQ267479 CB111995 AA627116 T94301 BQ222222 W60963 BM707097 BM673258 CF529570 CD679090 CR625014 BM707287
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KRT10 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
|---|
|
| SP1: | | | - | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for KRT10
|
Expression
for KRT10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAACAAAG
About this image
See KRT10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT10
SOURCE GeneReport for Unigene cluster: Hs.99936
UniProtKB/Swiss-Prot: K1C10_HUMAN, P13645Tissue specificity: Seen in all suprabasal cell layers including stratum corneum
SABiosciences Expression via Pathway-Focused PCR Arrays including KRT10:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT10 |
Orthologs
for KRT10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT10 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KRT10 (if available)
TreeFam Gene Tree for KRT10 (if available) |
Paralogs
for KRT10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT10 gene
- KRT172 KRT132 KRT162 KRT262 KRT122 KRT182 KRT252 KRT152
- KRT202 KRT272 KRT242 KRT192 KRT92 KRT282 KRT142 KRT232
18/59 SIMAP similar genes for KRT10 using alignment to 1 protein entry: K1C10_HUMAN(see all similar genes):JUP GUCA1B KRT15 K14 KRT27 type I hair keratin
KRT12 KRT13 KRT14 KRT19 KRT25 keratin
KRT16 KRT24 KRT28 KRT31 KRT32 KRT33A
KRT10 for paralogs About GeneDecksing
|
Genomic Variants
for KRT10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: K1C10_HUMAN, P13645Polymorphism: A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560)
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT10 (38974369 - 38978863 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT10: --
Human Gene Mutation Database (HGMD): KRT10
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT10 |
|
Disorders
/ Diseases
for KRT10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT10 for disorders About GeneDecksing
OMIM gene information: 148080
OMIM disorders: 113800 607602 609165
UniProtKB/Swiss-Prot: K1C10_HUMAN, P13645
Defects in KRT10 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]. An autosomal dominant skindisorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood.Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a fewweeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclicichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiformerythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenifiedplaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE isdramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the bodysurface and can persist for several weeks or even months Defects in KRT10 are the cause of reticular congenital ichthyosiform erythroderma (CRIE) [MIM:609165]; alsocalled ichthyosis with confetti (IWC) or reticular erythrokeratoderma. CRIE is a rare skin condition characterized byslowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. Thecondition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearingin late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis,and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloiddeposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of finefilaments in the upper epidermis
20/75  diseases for KRT10 (see all 75): About MalaCardsepidermolytic hyperkeratosis inflammatory linear verrucous epidermal nevus steatocystoma multiplex cyclic ichthyosis with epidermolytic hyperkeratosis
congenital ichthyosiform erythroderma epidermolysis bullosa simplex nonepidermolytic palmoplantar keratoderma keratosis
epidermolysis bullosa middle ear cholesteatoma epidermal nevus ichthyosis bullosa of siemens
lichen planus ichthyosis epidermolytic acanthoma cervical intraepithelial neoplasia
hidradenitis suppurativa nodular hidradenoma oral lichen planus ichthyosis with confetti
6 diseases from the University of Copenhagen DISEASES database for KRT10:Epidermolytic hyperkeratosis Keratosis Psoriasis Epidermolysis bullosa simplex
Congenital ichthyosiform erythroderma Nodular hidradenoma 10/42 Novoseek disease relationships for KRT10 gene (see all 42) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bullous congenital ichthyosiform erythroderma |
93.5 |
22 |
18219278 (2), 19689541 (2), 11204523 (2), 9028791 (1) (see all 15) |
| epidermolytic ichthyosis, annular |
85.6 |
3 |
10511478 (1), 9856845 (1), 9036939 (1) |
| hyperkeratosis |
76.1 |
10 |
16911278 (1), 14705805 (1), 1696852 (1), 7969162 (1) (see all 7) |
| epidermolysis bullosa simplex |
73 |
1 |
8595410 (1) |
| ichthyosis |
72.1 |
4 |
16029326 (1), 8595410 (1), 11558869 (1) |
| psoriasis |
70.7 |
11 |
15319153 (2), 16191851 (1), 10195395 (1), 10971053 (1) (see all 6) |
| keratoderma palmoplantar |
70.5 |
6 |
19443303 (2), 10597140 (1), 11558869 (1), 12234709 (1) |
| parakeratosis |
68 |
1 |
7969162 (1) |
| skin diseases |
63.3 |
8 |
14681042 (1), 12837696 (1), 7512983 (1), 19689541 (1) (see all 7) |
| carcinoma squamous cell |
57.2 |
21 |
15588557 (4), 1379783 (2), 8857642 (2), 7522949 (1) (see all 14) |
Export disorders for KRT10 gene to outside databases
|
Publications
for KRT10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT10 gene, integrated from 9 sources (see all 397):
(articles sorted by number of sources associating them with KRT10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel substitution in keratin 10 in epidermolytic hyperkeratosis. (PubMed id 10201536)1, 2, 9 Arin M.J.... Roop D.R. (1999)
- Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis. (PubMed id 7508181)1, 2, 9 Chipev C.C.... Bale S.J. (1994)
- Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. (PubMed id 7512983)1, 2, 9 Syder A.J.... Fuchs E. (1994)
- Genetic and clinical mosaicism in a type of epidermal nevus. (PubMed id 7526210)1, 2, 9 Paller A.S....Fuchs E. (1994)
- A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma. (PubMed id 9856845)1, 2, 9 Suga Y.... Roop D.R. (1998)
- A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma. (PubMed id 9036939)1, 2, 9 Joh G.-Y.... Roop D.R. (1997)
- Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats. (PubMed id 1378806)1, 2, 9 Tkachenko A.V....Kisselev L.L. (1992)
- Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. (PubMed id 7507150)1, 2, 9 Rothnagel J.A.... Roop D.R. (1994)
- The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. (PubMed id 1381287)1, 2, 9 Cheng J.... Fuchs E. (1992)
- Mitotic recombination in patients with ichthyosis cau ses reversion of dominant mutations in KRT10. (PubMed id 20798280)1, 2 Choate K.A....Lifton R.P. (2010)
|
External Searches for KRT10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT10 | Pharmacogenomics, SNPs, Pathways | | Human Intermediate Filament Mutation Database | http://www.interfil.org | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT10 | | Wikipedia | http://en.wikipedia.org/wiki/Keratin_10 |
|
| | |
About This Section
| Patent Information for KRT10 gene:
Search GeneIP for patents involving KRT10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KRT10 | | OriGene shRNA RFP for KRT10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT10 | | OriGene 3'-UTR Clone for KRT10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KRT10 | | OriGene Custom Protein Services for KRT10 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT10 |
| |
 |  |  |  | |
| | Antibodies & Assays for KRT10 (K10) |
| | | | Search Tocris compounds for KRT10 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KRT10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT10 |
|  |  |  | | | | ThermoFisher Antibody for KRT10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT10 |
|
|
|
|
