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Aliases for KRT10 Gene

Aliases for KRT10 Gene

  • Keratin 10, Type I 2 3
  • Cytokeratin 10 2 3
  • Keratin-10 3 4
  • CK-10 3 4
  • BCIE 3 6
  • EHK 3 6
  • KPP 3 4
  • BIE 3 6
  • K10 3 4
  • Keratosis Palmaris Et Plantaris 2
  • Keratin, Type I Cytoskeletal 10 3
  • Epidermolytic Hyperkeratosis 2
  • Cytokeratin-10 4
  • Keratin 10 2
  • CK10 3

External Ids for KRT10 Gene

Previous HGNC Symbols for KRT10 Gene

  • KPP

Previous GeneCards Identifiers for KRT10 Gene

  • GC17M038474
  • GC17M041150
  • GC17M038763
  • GC17M039347
  • GC17M036227
  • GC17M038974
  • GC17M034768

Summaries for KRT10 Gene

Entrez Gene Summary for KRT10 Gene

  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT10 Gene

KRT10 (Keratin 10, Type I) is a Protein Coding gene. Diseases associated with KRT10 include epidermolytic hyperkeratosis and ichthyosis with confetti. Among its related pathways are Staphylococcus aureus infection and Cytoskeletal Signaling. GO annotations related to this gene include structural constituent of epidermis. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT10 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT10 Gene

Genomics for KRT10 Gene

Regulatory Elements for KRT10 Gene

Genomic Location for KRT10 Gene

Start:
40,818,117 bp from pter
End:
40,822,611 bp from pter
Size:
4,495 bases
Orientation:
Minus strand

Genomic View for KRT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT10 Gene

Proteins for KRT10 Gene

  • Protein details for KRT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13645-K1C10_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 10
    Protein Accession:
    P13645
    Secondary Accessions:
    • Q14664
    • Q8N175

    Protein attributes for KRT10 Gene

    Size:
    584 amino acids
    Molecular mass:
    58827 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    SequenceCaution:
    • Sequence=AAA59468.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KRT10 Gene

neXtProt entry for KRT10 Gene

Proteomics data for KRT10 Gene at MOPED

Post-translational modifications for KRT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KRT10 (K10)

No data available for DME Specific Peptides for KRT10 Gene

Domains for KRT10 Gene

Gene Families for KRT10 Gene

HGNC:
  • IFF1 :Intermediate filaments type I, keratins (acidic)

Suggested Antigen Peptide Sequences for KRT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13645

UniProtKB/Swiss-Prot:

K1C10_HUMAN :
  • P13645
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT10: view

Function for KRT10 Gene

Molecular function for KRT10 Gene

GENATLAS Biochemistry: keratin 10,type I,suprabasal (spinous) layer,dimerizing with KRT1,also with KRT9

Gene Ontology (GO) - Molecular Function for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0030280 structural constituent of epidermis NAS 2459124
genes like me logo Genes that share ontologies with KRT10: view
genes like me logo Genes that share phenotypes with KRT10: view

Animal Models for KRT10 Gene

MGI Knock Outs for KRT10:

miRNA for KRT10 Gene

miRTarBase miRNAs that target KRT10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KRT10 Gene

Localization for KRT10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT10 Gene COMPARTMENTS Subcellular localization image for KRT10 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 22170488
GO:0005882 intermediate filament NAS 2459124
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KRT10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT10 Gene

Pathways for KRT10 Gene

genes like me logo Genes that share pathways with KRT10: view

Pathways by source for KRT10 Gene

1 Cell Signaling Technology pathway for KRT10 Gene
1 KEGG pathway for KRT10 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KRT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030216 keratinocyte differentiation IEP 22170488
GO:0030855 epithelial cell differentiation --
GO:0071277 cellular response to calcium ion IEA --
genes like me logo Genes that share ontologies with KRT10: view

Compounds for KRT10 Gene

(38) Novoseek inferred chemical compound relationships for KRT10 Gene

Compound -log(P) Hits PubMed IDs
calcipotriol 72.4 5
pd153035 57.7 2
retinoic acid 52.2 11
dithranol 51.8 1
tazarotene 49.3 2
genes like me logo Genes that share compounds with KRT10: view

Transcripts for KRT10 Gene

mRNA/cDNA for KRT10 Gene

(283) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT10 Gene

Keratin 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT10 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for KRT10 Gene

GeneLoc Exon Structure for
KRT10
ECgene alternative splicing isoforms for
KRT10

Expression for KRT10 Gene

mRNA expression in normal human tissues for KRT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (27.4) and Skin - Not Sun Exposed (Suprapubic) (21.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT10 Gene

SOURCE GeneReport for Unigene cluster for KRT10 Gene Hs.99936

mRNA Expression by UniProt/SwissProt for KRT10 Gene

P13645-K1C10_HUMAN
Tissue specificity: Seen in all suprabasal cell layers including stratum corneum
genes like me logo Genes that share expressions with KRT10: view

In Situ Assay Products

Orthologs for KRT10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT10 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT10 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt10 16
Krt10 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KRT10 36
  • 75 (a)
OneToOne
Species with no ortholog for KRT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT10 Gene

ENSEMBL:
Gene Tree for KRT10 (if available)
TreeFam:
Gene Tree for KRT10 (if available)

Paralogs for KRT10 Gene

genes like me logo Genes that share paralogs with KRT10: view

Variants for KRT10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KRT10 Gene

P13645-K1C10_HUMAN
A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560)

Sequence variations from dbSNP and Humsavar for KRT10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_003826 Epidermolytic hyperkeratosis (EHK)
VAR_003827 Epidermolytic hyperkeratosis (EHK)
VAR_003828 Epidermolytic hyperkeratosis (EHK)
VAR_003829 Epidermolytic hyperkeratosis (EHK)
VAR_003830 Epidermolytic hyperkeratosis (EHK)

Structural Variations from Database of Genomic Variants (DGV) for KRT10 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294

Relevant External Links for KRT10 Gene

HapMap Linkage Disequilibrium report
KRT10
Human Gene Mutation Database (HGMD)
KRT10

Disorders for KRT10 Gene

(3) OMIM Diseases for KRT10 Gene (148080)

UniProtKB/Swiss-Prot

K1C10_HUMAN
  • Epidermolytic hyperkeratosis (EHK) [MIM:113800]: An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop. {ECO:0000269 PubMed:10201536, ECO:0000269 PubMed:1380725, ECO:0000269 PubMed:1381287, ECO:0000269 PubMed:21271994, ECO:0000269 PubMed:7507150, ECO:0000269 PubMed:7507152, ECO:0000269 PubMed:7508181, ECO:0000269 PubMed:7512983, ECO:0000269 Ref.7}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ichthyosis annular epidermolytic (AEI) [MIM:607602]: A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months. {ECO:0000269 PubMed:9036939, ECO:0000269 PubMed:9856845}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Erythroderma, ichthyosiform, congenital reticular (CRIE) [MIM:609165]: A rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis. {ECO:0000269 PubMed:20798280}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(42) Novoseek inferred disease relationships for KRT10 Gene

Disease -log(P) Hits PubMed IDs
bullous congenital ichthyosiform erythroderma 93.5 18
epidermolytic ichthyosis, annular 85.6 3
hyperkeratosis 76.1 7
epidermolysis bullosa simplex 73 1
ichthyosis 72.1 3
genes like me logo Genes that share disorders with KRT10: view

Publications for KRT10 Gene

  1. Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats. (PMID: 1378806) Tkachenko A.V. … Kisselev L.L. (Gene 1992) 3 4 23
  2. The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. (PMID: 1381287) Cheng J. … Fuchs E. (Cell 1992) 3 4 23
  3. Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. (PMID: 7507150) Rothnagel J.A. … Roop D.R. (J. Invest. Dermatol. 1994) 3 4 23
  4. Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis. (PMID: 7508181) Chipev C.C. … Bale S.J. (Am. J. Hum. Genet. 1994) 3 4 23
  5. Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. (PMID: 7512983) Syder A.J. … Fuchs E. (J. Clin. Invest. 1994) 3 4 23

Products for KRT10 Gene

Sources for KRT10 Gene

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