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Aliases for KRR1 Gene

Aliases for KRR1 Gene

  • KRR1, Small Subunit Processome Component Homolog 2 3 5
  • KRR-R Motif-Containing Protein 1 3 4
  • HIV-1 Rev Binding Protein 2 2 3
  • HIV-1 Rev-Binding Protein 2 3 4
  • Rev-Interacting Protein 1 3 4
  • RIP-1 3 4
  • HRB2 3 4
  • KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • KRR1, Small Subunit (SSU) Processome Component, Homolog 3
  • KRR1 Small Subunit Processome Component Homolog 3
  • Rev Interacting Protein 3

External Ids for KRR1 Gene

Previous HGNC Symbols for KRR1 Gene

  • HRB2

Previous GeneCards Identifiers for KRR1 Gene

  • GC12M074178
  • GC12M075891
  • GC12M072941

Summaries for KRR1 Gene

GeneCards Summary for KRR1 Gene

KRR1 (KRR1, Small Subunit Processome Component Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for KRR1 Gene

  • Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Wiki entry for KRR1 Gene

Additional gene information for KRR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRR1 Gene

Genomics for KRR1 Gene

GeneHancer (GH) Regulatory Elements for KRR1 Gene

Promoters and enhancers for KRR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I075508 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 622.9 +0.9 916 4.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12I075477 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.3 +29.9 29876 7.5 HDGF ATF1 RB1 ZSCAN4 SIN3A BMI1 ZBTB40 RAD21 YY1 ZNF366 GLIPR1 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497
GH12I075329 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 35.7 +181.4 181412 1.4 PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 CAPS2 KRR1 LOC100652897 GLIPR1L2 ENSG00000273987 LOC100419702
GH12I075388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.7 +121.2 121157 3.9 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143 FOS ZNF263 GLIPR1L2 CAPS2 KRR1 GLIPR1 GLIPR1L1
GH12I076346 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.3 -836.3 -836272 2.8 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B BBS10 KRR1 RN7SKP172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRR1 gene promoter:

Genomic Locations for KRR1 Gene

Genomic Locations for KRR1 Gene
chr12:75,490,861-75,511,638
(GRCh38/hg38)
Size:
20,778 bases
Orientation:
Minus strand
chr12:75,890,684-75,905,418
(GRCh37/hg19)

Genomic View for KRR1 Gene

Genes around KRR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRR1 Gene

Proteins for KRR1 Gene

  • Protein details for KRR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13601-KRR1_HUMAN
    Recommended name:
    KRR1 small subunit processome component homolog
    Protein Accession:
    Q13601
    Secondary Accessions:
    • A0FIK6
    • A0JLP0
    • B2R989
    • E7EUQ0
    • Q8NEA8
    • Q8TC37
    • Q96AT5

    Protein attributes for KRR1 Gene

    Size:
    381 amino acids
    Molecular mass:
    43665 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.
    SequenceCaution:
    • Sequence=AAB00557.1; Type=Frameshift; Positions=265, 300; Evidence={ECO:0000305}; Sequence=AAH05225.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRR1 Gene

Post-translational modifications for KRR1 Gene

  • Ubiquitination at posLast=106106, isoforms=2121, and posLast=220220

Other Protein References for KRR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRR1 Gene

Domains & Families for KRR1 Gene

Gene Families for KRR1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRR1 Gene

Suggested Antigen Peptide Sequences for KRR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13601

UniProtKB/Swiss-Prot:

KRR1_HUMAN :
  • Belongs to the KRR1 family.
Family:
  • Belongs to the KRR1 family.
genes like me logo Genes that share domains with KRR1: view

Function for KRR1 Gene

Molecular function for KRR1 Gene

UniProtKB/Swiss-Prot Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Phenotypes From GWAS Catalog for KRR1 Gene

Gene Ontology (GO) - Molecular Function for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 19590578
genes like me logo Genes that share ontologies with KRR1: view
genes like me logo Genes that share phenotypes with KRR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRR1 Gene

Localization for KRR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRR1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR (Ref.6).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRR1 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with KRR1: view

Pathways & Interactions for KRR1 Gene

genes like me logo Genes that share pathways with KRR1: view

Gene Ontology (GO) - Biological Process for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with KRR1: view

No data available for SIGNOR curated interactions for KRR1 Gene

Drugs & Compounds for KRR1 Gene

No Compound Related Data Available

Transcripts for KRR1 Gene

Unigene Clusters for KRR1 Gene

KRR1, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for KRR1 Gene

GeneLoc Exon Structure for
KRR1
ECgene alternative splicing isoforms for
KRR1

Expression for KRR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRR1 Gene

This gene is overexpressed in Pancreas (10.8), Lung (8.5), Peripheral blood mononuclear cells (6.9), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KRR1 Gene



Protein tissue co-expression partners for KRR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRR1 Gene:

KRR1

SOURCE GeneReport for Unigene cluster for KRR1 Gene:

Hs.645517

Evidence on tissue expression from TISSUES for KRR1 Gene

  • Bone marrow(4.3)
genes like me logo Genes that share expression patterns with KRR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRR1 Gene

Orthologs for KRR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KRR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRR1 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
KRR1 33
  • 90.11 (n)
-- 34
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KRR1 33 34
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia KRR1 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krr1 33 16 34
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Krr1 33
  • 85.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRR1 33 34
  • 79 (n)
lizard
(Anolis carolinensis)
Reptilia KRR1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krr1 33
  • 75.95 (n)
Str.2631 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6585 33
zebrafish
(Danio rerio)
Actinopterygii krr1 33 34
  • 68.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta dbe 33 34
  • 59.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007912 33
  • 56.81 (n)
worm
(Caenorhabditis elegans)
Secernentea C05C8.2 33 34
  • 58.65 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRR1 33 34 36
  • 60.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00506g 33
  • 58.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR744W 33
  • 55.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08420 33
  • 58.2 (n)
rice
(Oryza sativa)
Liliopsida Os10g0452800 33
  • 57.14 (n)
Os.13981 33
barley
(Hordeum vulgare)
Liliopsida Hv.6360 33
wheat
(Triticum aestivum)
Liliopsida Ta.1012 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mis3 33
  • 62.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3000 34
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07041 33
  • 54.18 (n)
Species where no ortholog for KRR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KRR1 Gene

ENSEMBL:
Gene Tree for KRR1 (if available)
TreeFam:
Gene Tree for KRR1 (if available)

Paralogs for KRR1 Gene

Pseudogenes.org Pseudogenes for KRR1 Gene

genes like me logo Genes that share paralogs with KRR1: view

No data available for Paralogs for KRR1 Gene

Variants for KRR1 Gene

Sequence variations from dbSNP and Humsavar for KRR1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000708245 -- 75,500,375(-) TCAATA/TCAATATCAATA intron_variant
rs1000779003 -- 75,506,811(-) G/A coding_sequence_variant, synonymous_variant
rs1000806805 -- 75,497,266(-) T/C downstream_transcript_variant
rs1000972255 -- 75,510,896(-) G/A intron_variant
rs1000984369 -- 75,503,724(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRR1 Gene

Variant ID Type Subtype PubMed ID
nsv470305 CNV gain 18288195
nsv826439 CNV gain 20364138

Variation tolerance for KRR1 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRR1 Gene

Disorders for KRR1 Gene

Additional Disease Information for KRR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KRR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRR1 Gene

Publications for KRR1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58

Products for KRR1 Gene

Sources for KRR1 Gene

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