Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRR1 Gene

Aliases for KRR1 Gene

  • KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2 3
  • KRR-R Motif-Containing Protein 1 3 4
  • HIV-1 Rev Binding Protein 2 2 3
  • HIV-1 Rev-Binding Protein 2 3 4
  • Rev-Interacting Protein 1 3 4
  • RIP-1 3 4
  • HRB2 3 4
  • Rev Interacting Protein 3

External Ids for KRR1 Gene

Previous HGNC Symbols for KRR1 Gene

  • HRB2

Previous GeneCards Identifiers for KRR1 Gene

  • GC12M074178
  • GC12M075891
  • GC12M072941

Summaries for KRR1 Gene

GeneCards Summary for KRR1 Gene

KRR1 (KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast)) is a Protein Coding gene. Diseases associated with KRR1 include hiv-1. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for KRR1 Gene

  • Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Wiki entry for KRR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRR1 Gene

Genomics for KRR1 Gene

Regulatory Elements for KRR1 Gene

Genomic Location for KRR1 Gene

Chromosome:
12
Start:
75,490,861 bp from pter
End:
75,511,638 bp from pter
Size:
20,778 bases
Orientation:
Minus strand

Genomic View for KRR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KRR1 Gene

Proteins for KRR1 Gene

  • Protein details for KRR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13601-KRR1_HUMAN
    Recommended name:
    KRR1 small subunit processome component homolog
    Protein Accession:
    Q13601
    Secondary Accessions:
    • A0FIK6
    • A0JLP0
    • B2R989
    • E7EUQ0
    • Q8NEA8
    • Q8TC37
    • Q96AT5

    Protein attributes for KRR1 Gene

    Size:
    381 amino acids
    Molecular mass:
    43665 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.
    SequenceCaution:
    • Sequence=AAB00557.1; Type=Frameshift; Positions=265, 300; Evidence={ECO:0000305}; Sequence=AAH05225.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRR1 Gene

Proteomics data for KRR1 Gene at MOPED

Post-translational modifications for KRR1 Gene

  • Ubiquitination at Lys 106, Lys 121, and Lys 220
  • Modification sites at PhosphoSitePlus

Other Protein References for KRR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRR1 Gene

Domains & Families for KRR1 Gene

Protein Domains for KRR1 Gene

Suggested Antigen Peptide Sequences for KRR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13601

UniProtKB/Swiss-Prot:

KRR1_HUMAN :
  • Contains 1 KH domain.
  • Belongs to the KRR1 family.
Domain:
  • Contains 1 KH domain.
Family:
  • Belongs to the KRR1 family.
genes like me logo Genes that share domains with KRR1: view

No data available for Gene Families for KRR1 Gene

Function for KRR1 Gene

Molecular function for KRR1 Gene

UniProtKB/Swiss-Prot Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Ontology (GO) - Molecular Function for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 19590578
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KRR1: view
genes like me logo Genes that share phenotypes with KRR1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRR1 Gene

Localization for KRR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRR1 Gene

Cytoplasm. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRR1 Gene COMPARTMENTS Subcellular localization image for KRR1 gene
Compartment Confidence
nucleus 5
extracellular 4

Gene Ontology (GO) - Cellular Components for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with KRR1: view

Pathways & Interactions for KRR1 Gene

SuperPathways for KRR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with KRR1: view

No data available for Pathways by source and SIGNOR curated interactions for KRR1 Gene

Drugs & Compounds for KRR1 Gene

No Compound Related Data Available

Transcripts for KRR1 Gene

Unigene Clusters for KRR1 Gene

KRR1, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for KRR1 Gene

GeneLoc Exon Structure for
KRR1
ECgene alternative splicing isoforms for
KRR1

Expression for KRR1 Gene

mRNA expression in normal human tissues for KRR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRR1 Gene

This gene is overexpressed in Pancreas (10.8), Lung (8.5), Peripheral blood mononuclear cells (6.9), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KRR1 Gene



SOURCE GeneReport for Unigene cluster for KRR1 Gene Hs.645517

genes like me logo Genes that share expression patterns with KRR1: view

Protein tissue co-expression partners for KRR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRR1 Gene

Orthologs for KRR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KRR1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Krr1 36
  • 92 (a)
OneToOne
Krr1 16
Krr1 35
  • 85.52 (n)
  • 92.76 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRR1 36
  • 100 (a)
OneToOne
KRR1 35
  • 99.65 (n)
  • 99.74 (a)
oppossum
(Monodelphis domestica)
Mammalia KRR1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
KRR1 35
  • 90.11 (n)
  • 92.78 (a)
cow
(Bos Taurus)
Mammalia KRR1 36
  • 93 (a)
OneToOne
KRR1 35
  • 90.46 (n)
  • 92.78 (a)
rat
(Rattus norvegicus)
Mammalia Krr1 35
  • 85.52 (n)
  • 92.49 (a)
chicken
(Gallus gallus)
Aves KRR1 36
  • 83 (a)
OneToOne
KRR1 35
  • 79 (n)
  • 85.55 (a)
lizard
(Anolis carolinensis)
Reptilia KRR1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6585 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2631 35
krr1 35
  • 75.95 (n)
  • 83.81 (a)
zebrafish
(Danio rerio)
Actinopterygii krr1 36
  • 71 (a)
OneToOne
krr1 35
  • 68.54 (n)
  • 79.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta dbe 36
  • 60 (a)
OneToOne
dbe 35
  • 59.22 (n)
  • 63.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007912 35
  • 56.81 (n)
  • 62.7 (a)
worm
(Caenorhabditis elegans)
Secernentea C05C8.2 36
  • 48 (a)
OneToOne
C05C8.2 35
  • 58.65 (n)
  • 58.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRR1 36
  • 61 (a)
OneToOne
KRR1 38
KRR1 35
  • 60.78 (n)
  • 64.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00506g 35
  • 58.44 (n)
  • 61.33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR744W 35
  • 55.03 (n)
  • 61.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08420 35
  • 58.2 (n)
  • 57.56 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1012 35
rice
(Oryza sativa)
Liliopsida Os10g0452800 35
  • 57.14 (n)
  • 57.48 (a)
Os.13981 35
barley
(Hordeum vulgare)
Liliopsida Hv.6360 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3000 36
  • 61 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mis3 35
  • 62.02 (n)
  • 63.12 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07041 35
  • 54.18 (n)
  • 59.2 (a)
Species with no ortholog for KRR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KRR1 Gene

ENSEMBL:
Gene Tree for KRR1 (if available)
TreeFam:
Gene Tree for KRR1 (if available)

Paralogs for KRR1 Gene

Pseudogenes.org Pseudogenes for KRR1 Gene

genes like me logo Genes that share paralogs with KRR1: view

No data available for Paralogs for KRR1 Gene

Variants for KRR1 Gene

Sequence variations from dbSNP and Humsavar for KRR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1275478 -- 75,512,373(+) TATAA(A/G)AGTTC upstream-variant-2KB
rs1552039 -- 75,512,214(+) CAGAG(A/G)GATGG upstream-variant-2KB
rs1604381 -- 75,504,560(+) TAGTT(C/T)TGTTT intron-variant
rs1604382 -- 75,504,662(+) GTGGA(C/T)TGCTC intron-variant
rs1679372 -- 75,511,385(+) TCAGC(G/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRR1 Gene

Variant ID Type Subtype PubMed ID
nsv899313 CNV Gain 21882294
nsv826439 CNV Gain 20364138
nsv470305 CNV Gain 18288195

Variation tolerance for KRR1 Gene

Residual Variation Intolerance Score: 26.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRR1 Gene

HapMap Linkage Disequilibrium report
KRR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRR1 Gene

Disorders for KRR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association
Search KRR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRR1

Genetic Association Database (GAD)
KRR1
Human Genome Epidemiology (HuGE) Navigator
KRR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRR1
genes like me logo Genes that share disorders with KRR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRR1 Gene

Publications for KRR1 Gene

  1. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. (PMID: 18207245) Lad S.P. … Li E. (Mol. Immunol. 2008) 23 67
  2. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. (PMID: 16968706) Fearns C. … Chuang T.H. (J. Biol. Chem. 2006) 23 67
  3. Ceramide mediates caspase-independent programmed cell death. (PMID: 16319138) Thon L. … Adam D. (FASEB J. 2005) 23 67
  4. Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. (PMID: 15280356) Sinha S.K. … Chaudhary P.M. (J. Biol. Chem. 2004) 23 67
  5. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. (PMID: 11359931) Chan H.Y. … O'Kane C.J. (Mol. Biol. Cell 2001) 2 67

Products for KRR1 Gene

Sources for KRR1 Gene

Back to Top

Content