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KRR1 Gene

protein-coding   GIFtS: 54
GCID: GC12M075891

KRR1, Small Subunit (SSU) Processome Component, Homolog...

(Previous names: HIV-1 rev binding protein 2, HIV-1 Rev binding protein 2)
(Previous symbol: HRB2)
  See KRR1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast)1 2     KRR-R Motif-Containing Protein 12 3
HRB21 2 3     RIP-12
HIV-1 Rev Binding Protein 21 2     KRR1 Small Subunit Processome Component Homolog2
Rev-Interacting Protein 12 3     Rev Interacting Protein2
HIV-1 Rev-Binding Protein 22 3     Rip-13

External Ids:    HGNC: 51761   Entrez Gene: 111032   Ensembl: ENSG000001116157   OMIM: 6128175   UniProtKB: Q136013   

Export aliases for KRR1 gene to outside databases

Previous GC identifers: GC12M074178 GC12M072941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KRR1 Gene:
KRR1 (KRR1, small subunit (SSU) processome component, homolog (yeast)) is a protein-coding gene. Diseases associated with KRR1 include hiv-1. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: KRR1_HUMAN, Q13601
Function: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and
ribosome assembly (By similarity)

Gene Wiki entry for KRR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRR1 gene promoter:
         HSF1 (long)   CUTL1   Nkx5-1   AREB6   NF-AT4   FOXC1   FOXO4   HSF1short   NF-AT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRR1 promoter sequence
   Search Chromatin IP Primers for KRR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.2   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q

KRR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M075891:  view genomic region     (about GC identifiers)

Start:
75,890,684 bp from pter      End:
75,905,418 bp from pter
Size:
14,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KRR1_HUMAN, Q13601 (See protein sequence)
Recommended Name: KRR1 small subunit processome component homolog  
Size: 381 amino acids; 43665 Da
Subunit: Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1
protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR
Sequence caution: Sequence=AAB00557.1; Type=Frameshift; Positions=265, 300; Sequence=AAH05225.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A0FIK6 A0JLP0 B2R989 E7EUQ0 Q8NEA8 Q8TC37 Q96AT5
Alternative splicing: 2 isoforms:  Q13601-1   Q13601-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRR1: NX_Q13601

Explore proteomics data for KRR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys121, Lys220
  • Modification sites at PhosphoSitePlus

  • See KRR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008974.5  
    ENSEMBL proteins: 
     ENSP00000229214   ENSP00000411740  

    KRR1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024166 rRNA_assembly_KRR1
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q13601

    ProtoNet protein and cluster: Q13601

    2 Blocks protein domains:
    IPB004087 KH domain
    IPB004088 KH


    UniProtKB/Swiss-Prot: KRR1_HUMAN, Q13601
    Similarity: Belongs to the KRR1 family
    Similarity: Contains 1 KH domain


    Find genes that share domains with KRR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KRR1_HUMAN, Q13601
    Function: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and
    ribosome assembly (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19590578
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with KRR1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for KRR1:
     Increased circadian period len  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRR1
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    miRNA
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    Block miRNA regulation of human, mouse, rat KRR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KRR1 (see all 23):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-340 hsa-miR-3133 hsa-miR-371-5p hsa-miR-500a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidKRR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRR1

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KRR1_HUMAN, Q13601: Cytoplasm. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to
    HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein
    VPR
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IEA--
    GO:0045171intercellular bridge IDA--

    Find genes that share ontologies with KRR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRR1
    Interactions:

        Search GeneGlobe Interaction Network for KRR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KRR1 (Q136011, 2, 3 ENSP000002292144) via UniProtKB, MINT, STRING, and/or I2D (see all 373)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    Find genes that share ontologies with KRR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRR1 gene: 
    NM_007043.6  

    Unigene Cluster for KRR1:

    KRR1, small subunit (SSU) processome component, homolog (yeast)
    Hs.645517  [show with all ESTs]
    Unigene Representative Sequence: BC033887
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229214(uc001sxt.3 uc009zsc.3) ENST00000438169 ENST00000551070
    ENST00000550023(uc010stx.2) ENST00000550898
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KRR1 (see all 23):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-340 hsa-miR-3133 hsa-miR-371-5p hsa-miR-500a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidKRR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRR1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRR1 (NM_007043)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KRR1
    OriGene qSTAR qPCR primer pairs in human, mouse for KRR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRR1
      QuantiTect SYBR Green Assays in human, mouse, rat KRR1
      QuantiFast Probe-based Assays in human, mouse, rat KRR1

    Additional mRNA sequence: 

    AK297602.1 AK313687.1 BC005225.1 BC014034.2 BC016778.1 BC026107.2 BC033887.2 EF010919.1 
    U55766.1 

    7 DOTS entries:

    DT.86840356  DT.214853  DT.95332533  DT.108317  DT.121185109  DT.99972143  DT.95296134 

    Selected AceView cDNA sequences (see all 260):

    CR613297 AI868693 CR604914 BC014034 AI911301 AA364358 AA878648 CB120020 
    AA805887 BE907240 AI858006 BM461602 BM982373 BE385926 BM271759 AW192333 
    BQ932153 N90129 AK093825 BU192253 BC005225 BX282143 AW468526 BX101828 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KRR1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                 -           -                                 
    SP2:                                -                                                               
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for KRR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACATCATT
    KRR1 Expression
    About this image


    KRR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
    KRR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645517
        Custom PCR Arrays for KRR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KRR1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krr11 , 5 KRR1, small subunit (SSU) processome component, homolog more1, 5 85.52(n)1
    92.76(a)1
      10 (59.97 cM)5
    527051  NM_178610.41  NP_848725.21 
     1119726645 
    chicken
    (Gallus gallus)
    Aves KRR11 KRR1, small subunit (SSU) processome component, homolog more 79(n)
    85.55(a)
      417863  NM_001030744.1  NP_001025915.1 
    lizard
    (Anolis carolinensis)
    Reptilia KRR16
    KRR1, small subunit (SSU) processome component, ho...
    80(a)
    1 ↔ 1
    5(40378201-40390041)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65852 Xenopus laevis, Similar to DNA segment, Chr 10, ERATO more 78.1(n)    BC041273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii krr11 KRR1, small subunit (SSU) processome component, homolog more 68.54(n)
    79.15(a)
      724049  NM_001045325.2  NP_001038790.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta dbe1 dribble 59.22(n)
    63.21(a)
      33269  NM_057892.4  NP_477240.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C05C8.21 C05C8.2 58.65(n)
    58.54(a)
      179115  NM_072436.5  NP_504837.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KRR1(YCL059C)4
    KRR11
    Essential nucleolar protein required for the synthesis more4
    KRR11
    60.78(n)1
    64.36(a)1
      3(23379-22429)4
    8502981, 4  NP_009872.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G084201 AT5G08420 58.2(n)
    57.56(a)
      830741  NM_120927.2  NP_196459.1 
    rice
    (Oryza sativa)
    Liliopsida Os.139812 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 68.33(n)    AK070158.1 


    ENSEMBL Gene Tree for KRR1 (if available)
    TreeFam Gene Tree for KRR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRR1 gene

    Find genes that share paralogs with KRR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KRR1
    PGOHUM00000248314


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRR1 (see all 238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs16793751,2
    C,F,H--75896565(+) GAAGAA/TAGATA 1 -- int1 trp318Minor allele frequency- T:0.04NS EA NA CSA WA 1914
    rs1872775021,2
    --75896617(+) TGTTAC/TGGAAG 1 -- int10--------
    rs1905347331,2
    --75896638(+) TGACTA/GCATCA 1 -- int10--------
    rs1442698561,2
    --75896639(+) GACTGC/TATCAC 1 -- int10--------
    rs22792441,2
    C,F,H--75896664(+) AACTAC/TTATCA 1 -- int130Minor allele frequency- T:0.19EA NS NA WA 4030
    rs16977521,2
    C,F,O,A,H--75896688(-) GAAGTG/TTTGGA 1 -- int131Minor allele frequency- T:0.40EA MN NA NS WA CSA 4170
    rs1443876611,2
    --75896727(+) TCCCCA/GTCAAT 1 -- int10--------
    rs1816954281,2
    --75896908(+) ACACAC/TAGAAG 1 -- int10--------
    rs1856504511,2
    --75896910(+) ACATAC/GAAGAG 1 -- int10--------
    rs1478629281,2
    --75896930(+) GGTGGA/GAGAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for KRR1 (75890684 - 75905418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KRR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470305CNV Gain18288195
    nsv899313CNV Gain21882294
    nsv826439CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612817    OMIM disorders: --

    1 disease for KRR1:    
    About MalaCards
    hiv-1


    Find genes that share disorders with KRR1           About GenesLikeMe

    2 Novoseek inferred disease relationships for KRR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 14.6 1 15280356 (1)
    tumors 4.65 1 15280356 (1)

    Genetic Association Database (GAD): KRR1
    Human Genome Epidemiology (HuGE) Navigator: KRR1 (3 documents)

    Export disorders for KRR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRR1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with KRR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. (PubMed id 11359931)1, 3 Chan H.Y....O'Kane C.J. (Mol. Biol. Cell 2001)
    7. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. (PubMed id 11027267)1, 3 Sasaki T....Kikuchi Y. (Mol. Cell. Biol. 2000)
    8. A novel cross-phylum family of proteins comprises a KRR1 (YCL059c) gene which is essential for viability of Saccharomyces cerevisiae cells. (PubMed id 8675026)1, 3 Gromadka R....Rytka J. (Gene 1996)
    9. Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. (PubMed id 7505766)1, 3 Epplen C. and Epplen J.T. (Hum. Genet. 1994)
    10. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11103 HGNC: 5176 AceView: HRB2 Ensembl:ENSG00000111615 euGenes: HUgn11103
    ECgene: KRR1 H-InvDB: KRR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRR1 gene:
    Search GeneIP for patents involving KRR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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