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Aliases for KRR1 Gene

Aliases for KRR1 Gene

  • KRR1, Small Subunit Processome Component Homolog 2 3 5
  • KRR-R Motif-Containing Protein 1 3 4
  • HIV-1 Rev Binding Protein 2 2 3
  • HIV-1 Rev-Binding Protein 2 3 4
  • Rev-Interacting Protein 1 3 4
  • RIP-1 3 4
  • HRB2 3 4
  • KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • KRR1, Small Subunit (SSU) Processome Component, Homolog 3
  • KRR1 Small Subunit Processome Component Homolog 3
  • Rev Interacting Protein 3

External Ids for KRR1 Gene

Previous HGNC Symbols for KRR1 Gene

  • HRB2

Previous GeneCards Identifiers for KRR1 Gene

  • GC12M074178
  • GC12M075891
  • GC12M072941

Summaries for KRR1 Gene

GeneCards Summary for KRR1 Gene

KRR1 (KRR1, Small Subunit Processome Component Homolog) is a Protein Coding gene. Diseases associated with KRR1 include Hiv-1. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for KRR1 Gene

  • Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Wiki entry for KRR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRR1 Gene

Genomics for KRR1 Gene

Regulatory Elements for KRR1 Gene

Enhancers for KRR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F075508 1.5 FANTOM5 ENCODE 56.1 +0.9 916 4.9 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12F075477 1.4 FANTOM5 ENCODE 34.2 +29.9 29877 7.5 HDGF ATF1 SIN3A YY1 FOS JUNB MIER2 PPARG KAT8 NFIL3 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497 GLIPR1
GH12F075507 1 FANTOM5 37.9 +4.3 4257 0.5 TBP ELF3 MLX ARID4B DMAP1 RAD21 THRB ZNF48 RARA SLC30A9 KRR1 GLIPR1L1 GLIPR1 CAPS2 GLIPR1L2 PHLDA1 KCNC2 ENSG00000257497
GH12F075950 1.7 FANTOM5 Ensembl ENCODE 16.4 -441.7 -441663 5.6 PKNOX1 ARNT CREB3L1 SIN3A DMAP1 FEZF1 ZNF2 YY1 CBX5 ZNF143 KRR1 PHLDA1 RPL21P98 LOC100652897 GLIPR1 RN7SL734P ENSG00000258091
GH12F076113 1.2 Ensembl ENCODE 23 -602.4 -602380 1.2 HDAC1 PKNOX1 CBX3 ATF1 ARNT TBL1XR1 PTRF CHAMP1 ZNF121 GTF3C2 KRR1 ENSG00000258304 NAP1L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRR1 on UCSC Golden Path with GeneCards custom track

Promoters for KRR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000433077 238 2000 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for KRR1 Gene

Chromosome:
12
Start:
75,490,861 bp from pter
End:
75,511,638 bp from pter
Size:
20,778 bases
Orientation:
Minus strand

Genomic View for KRR1 Gene

Genes around KRR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRR1 Gene

Proteins for KRR1 Gene

  • Protein details for KRR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13601-KRR1_HUMAN
    Recommended name:
    KRR1 small subunit processome component homolog
    Protein Accession:
    Q13601
    Secondary Accessions:
    • A0FIK6
    • A0JLP0
    • B2R989
    • E7EUQ0
    • Q8NEA8
    • Q8TC37
    • Q96AT5

    Protein attributes for KRR1 Gene

    Size:
    381 amino acids
    Molecular mass:
    43665 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.
    SequenceCaution:
    • Sequence=AAB00557.1; Type=Frameshift; Positions=265, 300; Evidence={ECO:0000305}; Sequence=AAH05225.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRR1 Gene

Post-translational modifications for KRR1 Gene

  • Ubiquitination at Lys 106, Lys 121, and Lys 220
  • Modification sites at PhosphoSitePlus

Other Protein References for KRR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRR1 Gene

Domains & Families for KRR1 Gene

Protein Domains for KRR1 Gene

Suggested Antigen Peptide Sequences for KRR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13601

UniProtKB/Swiss-Prot:

KRR1_HUMAN :
  • Contains 1 KH domain.
  • Belongs to the KRR1 family.
Domain:
  • Contains 1 KH domain.
Family:
  • Belongs to the KRR1 family.
genes like me logo Genes that share domains with KRR1: view

No data available for Gene Families for KRR1 Gene

Function for KRR1 Gene

Molecular function for KRR1 Gene

UniProtKB/Swiss-Prot Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Ontology (GO) - Molecular Function for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19590578
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KRR1: view
genes like me logo Genes that share phenotypes with KRR1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRR1 Gene

Localization for KRR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRR1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR (Ref.6).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRR1 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2

Gene Ontology (GO) - Cellular Components for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KRR1: view

Pathways & Interactions for KRR1 Gene

genes like me logo Genes that share pathways with KRR1: view

Gene Ontology (GO) - Biological Process for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with KRR1: view

No data available for SIGNOR curated interactions for KRR1 Gene

Transcripts for KRR1 Gene

Unigene Clusters for KRR1 Gene

KRR1, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for KRR1 Gene

GeneLoc Exon Structure for
KRR1
ECgene alternative splicing isoforms for
KRR1

Expression for KRR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRR1 Gene

This gene is overexpressed in Pancreas (10.8), Lung (8.5), Peripheral blood mononuclear cells (6.9), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KRR1 Gene



Protein tissue co-expression partners for KRR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRR1 Gene:

KRR1

SOURCE GeneReport for Unigene cluster for KRR1 Gene:

Hs.645517
genes like me logo Genes that share expression patterns with KRR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRR1 Gene

Orthologs for KRR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KRR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRR1 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
KRR1 34
  • 90.11 (n)
-- 35
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KRR1 34 35
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia KRR1 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krr1 34 16 35
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Krr1 34
  • 85.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRR1 34 35
  • 79 (n)
lizard
(Anolis carolinensis)
Reptilia KRR1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krr1 34
  • 75.95 (n)
Str.2631 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6585 34
zebrafish
(Danio rerio)
Actinopterygii krr1 34 35
  • 68.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta dbe 34 35
  • 59.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007912 34
  • 56.81 (n)
worm
(Caenorhabditis elegans)
Secernentea C05C8.2 34 35
  • 58.65 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRR1 34 35 37
  • 60.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00506g 34
  • 58.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR744W 34
  • 55.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08420 34
  • 58.2 (n)
rice
(Oryza sativa)
Liliopsida Os10g0452800 34
  • 57.14 (n)
Os.13981 34
barley
(Hordeum vulgare)
Liliopsida Hv.6360 34
wheat
(Triticum aestivum)
Liliopsida Ta.1012 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mis3 34
  • 62.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3000 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07041 34
  • 54.18 (n)
Species where no ortholog for KRR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KRR1 Gene

ENSEMBL:
Gene Tree for KRR1 (if available)
TreeFam:
Gene Tree for KRR1 (if available)

Paralogs for KRR1 Gene

Pseudogenes.org Pseudogenes for KRR1 Gene

genes like me logo Genes that share paralogs with KRR1: view

No data available for Paralogs for KRR1 Gene

Variants for KRR1 Gene

Sequence variations from dbSNP and Humsavar for KRR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10506667 -- 75,513,508(-) ACTCC(C/T)TATTC upstream-variant-2KB
rs1051446 -- 75,500,334(+) TTCCA(C/T)CTTGC intron-variant, utr-variant-3-prime
rs1056900 -- 75,499,706(-) TTTTT(C/T)TTTTT utr-variant-3-prime
rs1056903 -- 75,499,624(+) TTTCT(A/C)GTATA utr-variant-3-prime
rs1056904 -- 75,499,619(-) GAGAA(A/C)GTGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRR1 Gene

Variant ID Type Subtype PubMed ID
nsv470305 CNV gain 18288195
nsv826439 CNV gain 20364138

Variation tolerance for KRR1 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRR1 Gene

Disorders for KRR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KRR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRR1

Genetic Association Database (GAD)
KRR1
Human Genome Epidemiology (HuGE) Navigator
KRR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRR1
genes like me logo Genes that share disorders with KRR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRR1 Gene

Publications for KRR1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for KRR1 Gene

Sources for KRR1 Gene

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