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Aliases for KRI1 Gene

Aliases for KRI1 Gene

  • KRI1 Homolog 2 3 5
  • KRI1 Homolog (S. Cerevisiae) 2

External Ids for KRI1 Gene

Previous GeneCards Identifiers for KRI1 Gene

  • GC19M010525
  • GC19M010663
  • GC19M010241

Summaries for KRI1 Gene

Entrez Gene Summary for KRI1 Gene

  • This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRI1 Gene

KRI1 (KRI1 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRI1 Gene

Genomics for KRI1 Gene

Regulatory Elements for KRI1 Gene

Enhancers for KRI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010564 1.7 FANTOM5 ENCODE dbSUPER 41.1 -1.4 -1356 5.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 KRI1 CDKN2D SLC44A2 TYK2
GH19G010595 1.6 FANTOM5 Ensembl ENCODE dbSUPER 40.3 -30.2 -30164 2.0 USF1 ZSCAN4 MAX EBF1 EGR1 ADNP RELB ETV6 IKZF2 MTA2 KRI1 CDKN2D SLC44A2 ICAM3 ATG4D ILF3 TYK2 DNM2 C19orf38 S1PR5
GH19G010552 1.4 Ensembl ENCODE dbSUPER 34.1 +11.9 11901 5.3 HDGF PKNOX1 AGO1 KLF17 RAD21 GLIS2 SCRT2 FOS ETV6 EGR2 KRI1 CDKN2D SLC44A2 ILF3 QTRT1 ILF3-AS1 MIR1238
GH19G010601 1.7 FANTOM5 ENCODE dbSUPER 23.5 -38.1 -38087 4.4 ARID4B DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5 REST TBX21 ZNF610 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 QTRT1 ZNF627 PRKCSH RPL10P15 ILF3-AS1
GH19G010514 1.6 FANTOM5 ENCODE dbSUPER 22.1 +48.8 48821 5.2 PKNOX1 FOXA2 SIN3A ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 SP3 S1PR5 KRI1 ATG4D ZNF846 LOC100419831 CDKN2D SLC44A2 RNU7-140P MIR1238 ILF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRI1 on UCSC Golden Path with GeneCards custom track

Promoters for KRI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000287406 237 1201 HDGF HNRNPUL1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for KRI1 Gene

Chromosome:
19
Start:
10,553,078 bp from pter
End:
10,566,037 bp from pter
Size:
12,960 bases
Orientation:
Minus strand

Genomic View for KRI1 Gene

Genes around KRI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRI1 Gene

Proteins for KRI1 Gene

  • Protein details for KRI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9T8-KRI1_HUMAN
    Recommended name:
    Protein KRI1 homolog
    Protein Accession:
    Q8N9T8
    Secondary Accessions:
    • Q2M1R5
    • Q2M1R7
    • Q7L5J7
    • Q96G92
    • Q9BU50
    • Q9H6I1
    • Q9H978

    Protein attributes for KRI1 Gene

    Size:
    703 amino acids
    Molecular mass:
    82598 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14357.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04240.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for KRI1 Gene

Post-translational modifications for KRI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRI1 Gene

No data available for DME Specific Peptides for KRI1 Gene

Domains & Families for KRI1 Gene

Protein Domains for KRI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9T8

UniProtKB/Swiss-Prot:

KRI1_HUMAN :
  • Belongs to the KRI1 family.
Family:
  • Belongs to the KRI1 family.
genes like me logo Genes that share domains with KRI1: view

No data available for Gene Families for KRI1 Gene

Function for KRI1 Gene

Gene Ontology (GO) - Molecular Function for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KRI1: view
genes like me logo Genes that share phenotypes with KRI1: view

Animal Model Products

miRNA for KRI1 Gene

miRTarBase miRNAs that target KRI1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRI1 Gene

Localization for KRI1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRI1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0030686 90S preribosome IBA --
genes like me logo Genes that share ontologies with KRI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRI1 Gene

Pathways & Interactions for KRI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
genes like me logo Genes that share ontologies with KRI1: view

No data available for Pathways by source and SIGNOR curated interactions for KRI1 Gene

Transcripts for KRI1 Gene

Unigene Clusters for KRI1 Gene

KRI1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:

Relevant External Links for KRI1 Gene

GeneLoc Exon Structure for
KRI1
ECgene alternative splicing isoforms for
KRI1

Expression for KRI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.3), CD8 Tcells (17.0), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KRI1 Gene



Protein tissue co-expression partners for KRI1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRI1 Gene:

KRI1

SOURCE GeneReport for Unigene cluster for KRI1 Gene:

Hs.709967

Evidence on tissue expression from TISSUES for KRI1 Gene

  • Lung(4.5)
  • Liver(4.2)
  • Nervous system(3.5)
  • Skin(3.3)
genes like me logo Genes that share expression patterns with KRI1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRI1 Gene

Orthologs for KRI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KRI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRI1 34 35
  • 96.54 (n)
cow
(Bos Taurus)
Mammalia KRI1 34 35
  • 86.64 (n)
dog
(Canis familiaris)
Mammalia KRI1 34 35
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia LOC687183 34
  • 80.95 (n)
mouse
(Mus musculus)
Mammalia Kri1 34 16 35
  • 80.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRI1 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRI1 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRI1 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kri1 34
  • 64.26 (n)
zebrafish
(Danio rerio)
Actinopterygii kri1 34 35
  • 62.04 (n)
Dr.20345 34
fruit fly
(Drosophila melanogaster)
Insecta CG5645 34 35
  • 55.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007295 34
  • 54.54 (n)
worm
(Caenorhabditis elegans)
Secernentea F54C9.9 34 35
  • 46.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRI1 35 37
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3549 35
  • 43 (a)
OneToOne
Species where no ortholog for KRI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KRI1 Gene

ENSEMBL:
Gene Tree for KRI1 (if available)
TreeFam:
Gene Tree for KRI1 (if available)

Paralogs for KRI1 Gene

No data available for Paralogs for KRI1 Gene

Variants for KRI1 Gene

Sequence variations from dbSNP and Humsavar for KRI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000006425 -- 10,566,702(+) CAGCC(-/GGCCAA)GGCCA upstream-variant-2KB, cds-indel
rs1000285206 -- 10,565,066(+) GATTT(C/T)AGAAG intron-variant
rs1000369452 -- 10,554,133(+) GGCTG(A/G)CTTCT reference, missense
rs1000557156 -- 10,565,693(+) CACGT(-/C)CAGGA intron-variant
rs1001331701 -- 10,564,027(+) TGTAA(C/T)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRI1 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for KRI1 Gene

Gene Damage Index Score: 17.21; 98.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRI1 Gene

Disorders for KRI1 Gene

Relevant External Links for KRI1

Genetic Association Database (GAD)
KRI1
Human Genome Epidemiology (HuGE) Navigator
KRI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRI1

No disorders were found for KRI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRI1 Gene

Publications for KRI1 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PMID: 12878157) Imabayashi H. … Umezawa A. (Exp. Cell Res. 2003) 2 3 64
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KRI1 Gene

Sources for KRI1 Gene

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