KREMEN2 Gene

Aliases
for KREMEN2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC16P003034 GC16P003014 GC16P002954

Summaries
for KREMEN2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for KREMEN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NC_018927.2  NT_010393.17  

SwitchGear Promoter luciferase reporter plasmid: KREMEN2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KREMEN2

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002986:  view genomic region     (about GC identifiers)

Proteins
for KREMEN2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

Explore proteomics data for KREMEN2 at MOPED

Post-translational modifications: 

KREMEN2 Human Recombinant Protein Products:

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	antibodies-online proteins for KREMEN2 (6 products)
	antibodies-online peptides for KREMEN2

KREMEN2 Antibody Products:

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KREMEN2 Assay Products:

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	antibodies-online kits for KREMEN2 (4 products)

Domains /
Families
for KREMEN2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8NCW0

Find genes that share domains with KREMEN2           About GenesLikeMe

Function
for KREMEN2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Kremen2)

genOway: Develop your customized and physiologically relevant rodent model for KREMEN2

miRNA Products:		miRTarBase miRNAs that target KREMEN2: hsa-mir-26b-5p (MIRT030146), hsa-mir-29a-3p (MIRT004564)
		Block miRNA regulation of human, mouse, rat KREMEN2 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate KREMEN2:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KREMEN2
		Predesigned siRNA for gene silencing in human, mouse, rat KREMEN2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KREMEN2

Clone Products:		OriGene clones in human, mouse for KREMEN2 (see all 9) OriGene ORF clones in mouse, rat for KREMEN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KREMEN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KREMEN2
		Browse ESI BIO Cell Lines and PureStem Progenitors for KREMEN2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

Localization
for KREMEN2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	3
plasma membrane	2
cytosol	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for KREMEN2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for KREMEN2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Wnt signaling network	Wnt signaling network
2	WNT Signaling	WNT Signaling
3	Presenilin action in Notch and Wnt signaling	Presenilin action in Notch and Wnt signaling

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KREMEN2

WNT Signaling

2 BioSystems Pathways for KREMEN2

	Wnt signaling network
	Presenilin action in Notch and Wnt signaling

2 Reactome Pathways for KREMEN2

	negative regulation of TCF-dependent signaling by WNT ligand antagonists
	TCF dependent signaling in response to WNT

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for KREMEN2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for KREMEN2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for KREMEN2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KREMEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACCTGTATG

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KREMEN2
		QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
		QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

Orthologs
for KREMEN2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for KREMEN2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for KREMEN2 gene

KREMEN1²  

3 SIMAP similar genes for KREMEN2 using alignment to 1 protein entry:     KREM2_HUMAN:

KREMEN1    APOA    LPAL2

Find genes that share paralogs with KREMEN2           About GenesLikeMe

Genomic Variants
for KREMEN2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KREMEN2 (see all 115)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs7317201,2	C,F,A	--	3012309(+)	TCCCCT/CCTCGC	4	--	us2k1		11		NA WA CSA EA	373
rs7317211,2	C,F,H	--	3012331(+)	AGGGCA/TGACAT	4	--	us2k1		10		NS EA NA WA	782
rs1379890211,2		--	3012361(+)	TGAGTA/GCCAAA	4	--	us2k1		0	--	--	--	--
rs7317221,2	C,F,H	--	3012384(+)	GGTGGG/AGGGTG	4	--	us2k1		8		NA EA NS WA	784
rs1932345211,2		--	3012413(+)	GTTTCC/TGTGAG	4	--	us2k1		0	--	--	--	--
rs797234441,2	C,F	--	3012565(+)	CAGTGC/ACAGGG	4	--	us2k1		1		WA	118
rs1419640161,2		--	3012579(+)	GAGGGA/GCGGTT	4	--	us2k1		0	--	--	--	--
rs286293211,2	C,F	--	3012659(+)	CGCACA/GGAGTC	4	--	us2k1		3		WA	122
rs1845452051,2		--	3012681(+)	CTGTCA/GCCACC	4	--	us2k1		0	--	--	--	--
rs124468961,2	H	--	3012740(+)	CACCGC/GCATTG	4	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for KREMEN2 (see all 11):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv509588	CNV	Insertion	20534489
nsv510673	CNV	Loss	20534489
nsv905170	CNV	Loss	21882294
nsv905185	CNV	Loss	21882294
dgv2575n71	CNV	Loss	21882294
dgv2576n71	CNV	Loss	21882294
dgv2578n71	CNV	Loss	21882294
dgv2577n71	CNV	Loss	21882294
nsv433167	CNV	Loss	18776910
nsv905162	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KREMEN2

DNA2.0 Custom Variant and Variant Library Synthesis for KREMEN2

Disorders / Diseases
for KREMEN2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for KREMEN2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)^{1, 3} Mao B....Niehrs C. (Nature 2002)
4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
5. Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)¹ Dun X....Hou J. (Mol. Cancer 2010)
6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (DNA Res. 2005)
7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (Nature 2004)
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (Gene 1994)
10. (PubMed id )² 

External Searches for KREMEN2 gene

Genome Databases showing KREMEN2 gene

Other Databases showing KREMEN2 gene

Specialized Databases showing KREMEN2 gene

Products
for KREMEN2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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