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KREMEN2 Gene

protein-coding   GIFtS: 52
GCID: GC16P002986

Kringle Containing Transmembrane Protein 2

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Aliases
for KREMEN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kringle Containing Transmembrane Protein 21 2
KRM22 3 5
Dickkopf Receptor 22 3
Kringle Domain-Containing Transmembrane Protein 22 3
Kringle-Containing Protein Marking The Eye And The Nose2 3
Kremen Protein 22

External Ids:    HGNC: 187971   Entrez Gene: 794122   Ensembl: ENSG000001316507   OMIM: 6098995   UniProtKB: Q8NCW03   

Export aliases for KREMEN2 gene to outside databases

Previous GC identifers: GC16P003034 GC16P003014 GC16P002954


Summaries
for KREMEN2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KREMEN2 Gene:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse
functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a
ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and
induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC,
and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this
gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for KREMEN2 Gene:
KREMEN2 (kringle containing transmembrane protein 2) is a protein-coding gene. An important paralog of this gene is KREMEN1.

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0
Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a
ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the
plasma membrane (By similarity)




Genomic Views
for KREMEN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KREMEN2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   NRSF form 1   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KREMEN2 promoter sequence
   Search Chromatin IP Primers for KREMEN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KREMEN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.11

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002986:  view genomic region     (about GC identifiers)

Start:
 3,013,945 bp from pter      End:
 3,018,384 bp from pter
Size:
 4,440 bases      Orientation:
 plus strand

Proteins
for KREMEN2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0 (See protein sequence)
Recommended Name: Kremen protein 2 precursor  
Size: 462 amino acids; 48849 Da
Subunit: Interacts with ERLEC1 (By similarity)
Secondary accessions: B4DXF6 I3L2S2 Q8N2J4 Q8NCW1 Q96GL8 Q9BTP9
Alternative splicing: 6 isoforms:  Q8NCW0-1   Q8NCW0-2   Q8NCW0-3   Q8NCW0-4   Q8NCW0-5   Q8NCW0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

Explore proteomics data for KREMEN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn222, Asn244, Asn351

    • See KREMEN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001240654.1  NP_001240655.1  NP_078783.1  NP_757384.1  

    ENSEMBL proteins: 
     ENSP00000304422   ENSP00000460578   ENSP00000459878   ENSP00000461860   ENSP00000322079  
     ENSP00000460917  
    Reactome Protein details: Q8NCW0

    KREMEN2 Human Recombinant Protein Products:

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         		antibodies-online proteins for KREMEN2 (6 products) 

         		antibodies-online peptides for KREMEN2

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    Domains /
    Families
    for KREMEN2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 Selected InterPro protein domains (see all 6):
     IPR000859 CUB_dom
     IPR000001 Kringle
     IPR002889 WSC_carb-bd
     IPR013806 Kringle-like
     IPR018056 Kringle_CS

    Graphical View of Domain Structure for InterPro Entry Q8NCW0

    ProtoNet protein and cluster: Q8NCW0

    3 Blocks protein domains:
    IPB000001 Kringle
    IPB000859 CUB domain
    IPB002889 Carbohydrate-binding WSC


    UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0
    Domain: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 WSC domain


    Find genes that share domains with KREMEN2           About GenesLikeMe


    Function
    for KREMEN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KREM2_HUMAN, Q8NCW0
    Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a
    ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the
    plasma membrane (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KREMEN2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kremen2):
     limbs/digits/tail  normal  reproductive system  skeleton 

    Find genes that share phenotypes with KREMEN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kremen2tm1Cni for KREMEN2

       genOway: Develop your customized and physiologically relevant rodent model for KREMEN2

    miRNA
    Products:            		miRTarBase miRNAs that target KREMEN2:
    hsa-mir-26b-5p (MIRT030146), hsa-mir-29a-3p (MIRT004564)

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    3 qRT-PCR Assays for microRNAs that regulate KREMEN2:
    hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KREMEN2

    Gene Editing
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    In Situ Assay
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    Localization
    for KREMEN2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KREM2_HUMAN, Q8NCW0: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KREMEN2           About GenesLikeMe


    Pathways & Interactions
    for KREMEN2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KREMEN2 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Wnt signaling network
    		Wnt signaling network
    2WNT Signaling
    		WNT Signaling
    3Presenilin action in Notch and Wnt signaling
    		Presenilin action in Notch and Wnt signaling


    Find genes that share SuperPaths with KREMEN2           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KREMEN2
        WNT Signaling

    2 BioSystems Pathways for KREMEN2
        Wnt signaling network
    Presenilin action in Notch and Wnt signaling

    2 Reactome Pathways for KREMEN2
        negative regulation of TCF-dependent signaling by WNT ligand antagonists
    TCF dependent signaling in response to WNT


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KREMEN2
    Interactions:

        GeneGlobe Interaction Network for KREMEN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for KREMEN2 (Q8NCW03 ENSP000003044224) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
    DKK1ENSP000003630814STRING: ENSP00000363081
    DKK2ENSP000002853114STRING: ENSP00000285311
    KREMEN1ENSP000003312424STRING: ENSP00000331242
    LRP5ENSP000002943044STRING: ENSP00000294304
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with KREMEN2           About GenesLikeMe



    Drugs & Compounds
    for KREMEN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KREMEN2 (KREM2)



    Transcripts
    for KREMEN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KREMEN2 gene (6 alternative transcripts): 
    NM_001253725.1  NM_001253726.1  NM_024507.3  NM_172229.2  NM_145347.1  NM_145348.1  

    Unigene Cluster for KREMEN2:

    Kringle containing transmembrane protein 2
    Hs.661128  [show with all ESTs]
    Unigene Representative Sequence: BC009383
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303746(uc002csg.3 uc010uwl.2 uc002csh.3 uc010bsx.3)
    ENST00000572045(uc010bsw.2 uc002csi.3) ENST00000575885 ENST00000571007
    ENST00000319500 ENST00000575769
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate KREMEN2:
    hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KREMEN2
      QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
      QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

    Additional mRNA sequence: 

    AB086355.1 AB086356.1 AB086357.1 AB086405.1 AK027669.1 AK075033.1 AK223422.1 AK301953.1 
    BC003533.1 BC009383.2 

    9 DOTS entries:

    DT.97844316  DT.100779022  DT.95261162  DT.100025471  DT.95261161  DT.91655832  DT.100779023  DT.100709448 
    DT.120674095 

    Selected AceView cDNA sequences (see all 87):

    AK075033 NM_172229 CR601297 BM784186 BX394026 BM783648 BM784393 AB086357 
    AB086405 BM783496 AK027669 NM_145348 BM784263 BM741846 BQ638144 BC003533 
    BM784098 BM743015 NM_024507 BM784114 AL542353 AB086355 BQ962982 BM744460 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                            -                       -     -         
    SP2:                                                                    -     -         
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for KREMEN2

    Expression
    for KREMEN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KREMEN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTGTATG
    KREMEN2 Expression
    About this image

    KREMEN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    KREMEN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661128
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    In Situ
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    Orthologs
    for KREMEN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for KREMEN2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kremen21 , 5 kringle containing transmembrane protein 21, 5 84.12(n)1
    88.26(a)1    		   17 (12.03 cM)5
    730161  NM_028416.21  NP_082692.11 
     237412005 
    lizard
    (Anolis carolinensis)    		 Reptilia KREMEN26
    		 kringle containing transmembrane protein 2
    		 47(a)
    		 1 ↔ 1
    		 GL343287.1(1160107-1202961)


    ENSEMBL Gene Tree for KREMEN2 (if available)
    TreeFam Gene Tree for KREMEN2 (if available)

    Paralogs
    for KREMEN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KREMEN2 gene
    KREMEN12  
    3 SIMAP similar genes for KREMEN2 using alignment to 1 protein entry:     KREM2_HUMAN:
    KREMEN1    APOA    LPAL2

    Find genes that share paralogs with KREMEN2           About GenesLikeMe



    Genomic Variants
    for KREMEN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KREMEN2 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs7317201,2
    		C,F,A--3012309(+) TCCCCT/CCTCGC 4 -- us2k111Minor allele frequency- C:0.43NA WA CSA EA 373
    rs7317211,2
    		C,F,H--3012331(+) AGGGCA/TGACAT 4 -- us2k110Minor allele frequency- T:0.28NS EA NA WA 782
    rs1379890211,2
    		--3012361(+) TGAGTA/GCCAAA 4 -- us2k10--------
    rs7317221,2
    		C,F,H--3012384(+) GGTGGG/AGGGTG 4 -- us2k18Minor allele frequency- A:0.03NA EA NS WA 784
    rs1932345211,2
    		--3012413(+) GTTTCC/TGTGAG 4 -- us2k10--------
    rs797234441,2
    		C,F--3012565(+) CAGTGC/ACAGGG 4 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1419640161,2
    		--3012579(+) GAGGGA/GCGGTT 4 -- us2k10--------
    rs286293211,2
    		C,F--3012659(+) CGCACA/GGAGTC 4 -- us2k13Minor allele frequency- G:0.23WA 122
    rs1845452051,2
    		--3012681(+) CTGTCA/GCCACC 4 -- us2k10--------
    rs124468961,2
    		H--3012740(+) CACCGC/GCATTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KREMEN2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509588CNV Insertion20534489
    nsv510673CNV Loss20534489
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    dgv2575n71CNV Loss21882294
    dgv2576n71CNV Loss21882294
    dgv2578n71CNV Loss21882294
    dgv2577n71CNV Loss21882294
    nsv433167CNV Loss18776910
    nsv905162CNV Gain21882294

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    Disorders / Diseases
    for KREMEN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 609899    OMIM disorders: --


    Find genes that share disorders with KREMEN2           About GenesLikeMe


    Export disorders for KREMEN2 gene to outside databases

    Publications
    for KREMEN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KREMEN2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with KREMEN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)1, 3 Mao B....Niehrs C. (Nature 2002)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)1 Dun X....Hou J. (Mol. Cancer 2010)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    10. (PubMed id )2 

    External Searches for KREMEN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Genome Databases showing KREMEN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79412 HGNC: 18797 AceView: KREMEN2 Ensembl:ENSG00000131650 euGenes: HUgn79412
    ECgene: KREMEN2 H-InvDB: KREMEN2

    Other Databases showing KREMEN2 gene

    (According to HUGE)
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    TryGeneCards Plus    		   --

    Specialized Databases showing KREMEN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KREMEN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KREMEN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for KREMEN2 gene:
    Search GeneIP for patents involving KREMEN2

    GeneCards and IP:
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    Products
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