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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KREMEN2 Gene

protein-coding GIFtS: 51
GCID: GC16P002986

kringle containing transmembrane protein 2

Explore 1 disease affiliated with
KREMEN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kringle Containing Transmembrane Protein 2¹ ²		Kringle-Containing Protein Marking The Eye And The Nose² ³
KRM2¹ ² ³ ⁵		MGC10791¹
Dickkopf Receptor 2² ³		Kremen Protein 2²
Kringle Domain-Containing Transmembrane Protein 2² ³

External Ids:	HGNC: 18797¹	Entrez Gene: 79412²	Ensembl: ENSG00000131650⁷	OMIM: 609899⁵	UniProtKB: Q8NCW0³

Export aliases for KREMEN2 gene to outside databases

Previous GC identifers: GC16P003034 GC16P003014 GC16P002954

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KREMEN2:

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse

functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary

membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid

endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains.

Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. (provided by

RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary

complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KREMEN2 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F NRSF form 1 E2F-2 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KREMEN2 promoter sequence

Search SABiosciences Chromatin IP Primers for KREMEN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KREMEN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.11

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002986: view genomic region (about GC identifiers)

Start:	3,013,945 bp from pter	End:	3,018,384 bp from pter
Size:	4,440 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0 (See protein sequence)

Recommended Name: Kremen protein 2 precursor

Size: 462 amino acids; 48849 Da

Subunit: Interacts with ERLEC1 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q8N2J4 Q8NCW1 Q96GL8 Q9BTP9

Alternative splicing: 4 isoforms: Q8NCW0-1 Q8NCW0-2 Q8NCW0-3 Q8NCW0-4

Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

KREMEN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001240654.1 NP_001240655.1 NP_078783.1 NP_757384.1

ENSEMBL proteins:

ENSP00000304422 ENSP00000460578 ENSP00000459878 ENSP00000461860 ENSP00000322079

ENSP00000460917

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KREMEN2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

KREMEN2 for ontologies About GeneDecksing

KREMEN2 Antibody Products:

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	Uscn ELISAs and CLIAs for KREMEN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KREMEN2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR002889 WSC_carb-bd

IPR018056 Kringle_CS

IPR000859 CUB_dom

IPR000001 Kringle

IPR013806 Kringle-like

Graphical View of Domain Structure for InterPro Entry Q8NCW0

ProtoNet protein and cluster: Q8NCW0

3 Blocks protein families:

IPB000001 Kringle

IPB000859 CUB domain

IPB002889 Carbohydrate-binding WSC

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Domain: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)

Similarity: Contains 1 CUB domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 WSC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary

complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane

(By similarity)

miRNA Products:		miRTarBase miRNAs that target KREMEN2: hsa-mir-29a (MIRT004564)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KREMEN2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KREMEN2 (see all 7) OriGene shRNA RFP: KREMEN2 OriGene siRNA: KREMEN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KREMEN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KREMEN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KREMEN2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KREMEN2
		Search LifeMap BioReagents cell lines for KREMEN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

KREMEN2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Kremen2^tm1Cni for KREMEN2
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kremen2):

limbs/digits/tail

normal

reproductive system

skeleton

KREMEN2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt signaling network

Wnt signaling network

1.00

Presenilin action in Notch and Wnt signaling

Presenilin action in Notch and Wnt signaling

1.00

WNT Signaling

WNT Signaling

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KREMEN2

WNT Signaling

2 BioSystems Pathways for KREMEN2

	Wnt signaling network
	Presenilin action in Notch and Wnt signaling

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KREMEN2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for KREMEN2 (Q8NCW0³ ENSP00000304422⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRP6	O75581³, ENSP00000261349⁴	I2D: score=1 STRING: ENSP00000261349
DKK1	ENSP00000363081⁴	STRING: ENSP00000363081
DKK2	ENSP00000285311⁴	STRING: ENSP00000285311
KREMEN1	ENSP00000331242⁴	STRING: ENSP00000331242
LRP5	ENSP00000294304⁴	STRING: ENSP00000294304

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016055	Wnt receptor signaling pathway	IEA	--

KREMEN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KREMEN2
Search CenterWatch for drugs/clinical trials and news about KREMEN2 / KREM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KREMEN2 gene (6 alternative transcripts):

NM_001253725.1 NM_001253726.1 NM_024507.3 NM_172229.2 NM_145347.1 NM_145348.1

Unigene Cluster for KREMEN2:

Kringle containing transmembrane protein 2

Hs.661128 [show with all ESTs]

Unigene Representative Sequence: BC009383

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303746(uc002csg.3 uc010uwl.2 uc002csh.3 uc010bsx.3)

ENST00000572045(uc010bsw.2 uc002csi.3) ENST00000575885 ENST00000571007

ENST00000319500 ENST00000575769

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KREMEN2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KREMEN2 (see all 7) OriGene shRNA RFP: KREMEN2 OriGene siRNA: KREMEN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KREMEN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KREMEN2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

Additional cDNA sequence:

AB086355.1 AB086356.1 AB086357.1 AB086405.1 AK027669.1 AK075033.1 AK223422.1 AK301953.1

BC003533.1 BC009383.2

9 DOTS entries:

DT.97844316 DT.100779022 DT.95261162 DT.100025471 DT.95261161 DT.91655832 DT.100779023 DT.100709448

DT.120674095

24/87 AceView cDNA sequences (see all 87):

BQ962982 BM744460 NM_024507 AB086356 BM784186 BM784320 AK075033 BC003533

BM784263 BM784393 BM741846 BM784156 AL542353 BQ638144 BC009383 BQ185819

NM_145347 BM784114 BE378841 NM_172229 CR611298 CR601297 AB086405 BM784098

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9
SP1:															-								-		-
SP2:																							-		-
SP3:
SP4:

ECgene alternative splicing isoforms for KREMEN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KREMEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTGTATG

About this image

KREMEN2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KREMEN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KREMEN2

SOURCE GeneReport for Unigene cluster: Hs.661128

SABiosciences Custom PCR Arrays for KREMEN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KREMEN2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KREMEN2 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kremen2^{1 , 5}	kringle containing transmembrane protein 2^{1, 5}	84.38(n)¹ 87.64(a)¹		17 (12.03 cM)⁵ 73016¹ NM_028416.2¹ NP_082692.1¹ 23741200⁵
lizard (Anolis carolinensis)	Reptilia	KREMEN2⁶	--	63(a)	1 ↔ 1	GL343287.1(1182154-1191039)

ENSEMBL Gene Tree for KREMEN2 (if available)
TreeFam Gene Tree for KREMEN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KREMEN2 gene

KREMEN1² PLAT² PLG² HGFAC² LPA² PLAU² HABP2² MST1²

F12² MST1L² HGF²

4 SIMAP similar genes for KREMEN2 using alignment to 3 protein entries: KREM2_HUMAN (see all proteins):

APOA KREMEN1 CUBN LPAL2

KREMEN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs731720^1,2	C,F,A,	--	3012309(+)	`TCCCCT/CCTCGC`	4	--	us2k¹		11		NA WA CSA EA	373
rs731721^1,2	C,F,H,	--	3012331(+)	`AGGGCA/TGACAT`	4	--	us2k¹		10		NS EA NA WA	782
rs137989021^1,2		--	3012361(+)	`TGAGTA/GCCAAA`	4	--	us2k¹		0	--	--	--	--
rs731722^1,2	C,F,H,	--	3012384(+)	`NNNNGG/AGGGTG`	4	--	us2k¹		8		NA EA NS WA	784
rs193234521^1,2		--	3012413(+)	`GTTTCC/TGTGAG`	4	--	us2k¹		0	--	--	--	--
rs79723444^1,2	F,	--	3012565(+)	`CAGTGC/ACAGGG`	4	--	us2k¹		1		WA	118
rs141964016^1,2		--	3012579(+)	`GAGGGA/GCGGTT`	4	--	us2k¹		0	--	--	--	--
rs28629321^1,2	C,F,	--	3012659(+)	`CGCACA/GGAGTC`	4	--	us2k¹		3		WA	122
rs184545205^1,2		--	3012681(+)	`CTGTCA/GCCACC`	4	--	us2k¹		0	--	--	--	--
rs12446896^1,2	H	--	3012740(+)	`CACCGC/GCATTG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KREMEN2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KREMEN2

DNA2.0 Custom Variant and Variant Library Synthesis for KREMEN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KREMEN2 for disorders           About GeneDecksing

OMIM gene information: 609899    OMIM disorders: --

1 disease for KREMEN2:    About MalaCards

myeloma

Export disorders for KREMEN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KREMEN2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with KREMEN2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)^{1, 3} Mao B....Niehrs C. (2002)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)¹ Dun X....Hou J. (2010)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. (PubMed id 18461655)⁹ Maehata T....Itoh F. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79412	HGNC: 18797	AceView: KREMEN2	Ensembl:ENSG00000131650	euGenes: HUgn79412
ECgene: KREMEN2	H-InvDB: KREMEN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KREMEN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KREMEN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KREMEN2 gene:
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KREMEN2 Gene

kringle containing transmembrane protein 2

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KREMEN2 Gene

kringle containing transmembrane protein 2

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