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KREMEN2 Gene

protein-coding GIFtS: 52
GCID: GC16P002986

Kringle Containing Transmembrane Protein 2

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Kringle Containing Transmembrane Protein 2¹ ²
KRM2² ³ ⁵
Dickkopf Receptor 2² ³
Kringle Domain-Containing Transmembrane Protein 2² ³
Kringle-Containing Protein Marking The Eye And The Nose² ³
Kremen Protein 2²

External Ids:	HGNC: 18797¹	Entrez Gene: 79412²	Ensembl: ENSG00000131650⁷	OMIM: 609899⁵	UniProtKB: Q8NCW0³

Export aliases for KREMEN2 gene to outside databases

Previous GC identifers: GC16P003034 GC16P003014 GC16P002954

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KREMEN2 Gene:

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse

functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a

ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and

induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC,

and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this

gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for KREMEN2 Gene:

KREMEN2 (kringle containing transmembrane protein 2) is a protein-coding gene. Diseases associated with KREMEN2 include myeloma. An important paralog of this gene is KREMEN1.

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a

ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the

plasma membrane (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NC_018927.2 NT_010393.17

Regulatory elements:

Regulatory transcription factor binding sites in the KREMEN2 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F NRSF form 1 E2F-2 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KREMEN2 promoter sequence

Search Chromatin IP Primers for KREMEN2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KREMEN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.11

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002986: view genomic region (about GC identifiers)

Start:	3,013,945 bp from pter	End:	3,018,384 bp from pter
Size:	4,440 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0 (See protein sequence)

Recommended Name: Kremen protein 2 precursor

Size: 462 amino acids; 48849 Da

Subunit: Interacts with ERLEC1 (By similarity)

Secondary accessions: B4DXF6 I3L2S2 Q8N2J4 Q8NCW1 Q96GL8 Q9BTP9

Alternative splicing: 6 isoforms: Q8NCW0-1 Q8NCW0-2 Q8NCW0-3 Q8NCW0-4 Q8NCW0-5 Q8NCW0-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

Explore proteomics data for KREMEN2 at MOPED

Post-translational modifications:

Glycosylation² at Asn49, Asn222, Asn244, Asn351

See KREMEN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001240654.1 NP_001240655.1 NP_078783.1 NP_757384.1

ENSEMBL proteins:

ENSP00000304422 ENSP00000460578 ENSP00000459878 ENSP00000461860 ENSP00000322079

ENSP00000460917

Reactome Protein details: Q8NCW0

KREMEN2 Human Recombinant Protein Products:

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KREMEN2 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):

IPR000859 CUB_dom

IPR000001 Kringle

IPR002889 WSC_carb-bd

IPR013806 Kringle-like

IPR018056 Kringle_CS

Graphical View of Domain Structure for InterPro Entry Q8NCW0

ProtoNet protein and cluster: Q8NCW0

3 Blocks protein domains:

IPB000001 Kringle

IPB000859 CUB domain

IPB002889 Carbohydrate-binding WSC

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Domain: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)

Similarity: Contains 1 CUB domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 WSC domain

KREMEN2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a

ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the

plasma membrane (By similarity)

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

KREMEN2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kremen2):

limbs/digits/tail

normal

reproductive system

skeleton

KREMEN2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Kremen2^tm1Cni for KREMEN2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KREMEN2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KREMEN2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KREMEN2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KREMEN2

miRNA Products:		miRTarBase miRNAs that target KREMEN2: hsa-mir-26b-5p (MIRT030146), hsa-mir-29a-3p (MIRT004564)

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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KREMEN2
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

KREM2_HUMAN, Q8NCW0: Membrane; Single-pass type I membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	3
plasma membrane	2
cytosol	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	IEA	--

KREMEN2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KREMEN2 About

See pathways by source

SuperPath

Contained pathways About

Wnt signaling network

Wnt signaling network

WNT Signaling

WNT Signaling

Presenilin action in Notch and Wnt signaling

Presenilin action in Notch and Wnt signaling

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KREMEN2

WNT Signaling

2 BioSystems Pathways for KREMEN2

	Wnt signaling network
	Presenilin action in Notch and Wnt signaling

2 Reactome Pathways for KREMEN2

	negative regulation of TCF-dependent signaling by WNT ligand antagonists
	TCF dependent signaling in response to WNT

KREMEN2 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for KREMEN2
Interactions:

GeneGlobe Interaction Network for KREMEN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for KREMEN2 (Q8NCW0³ ENSP00000304422⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRP6	O75581³, ENSP00000261349⁴	I2D: score=1 STRING: ENSP00000261349
DKK1	ENSP00000363081⁴	STRING: ENSP00000363081
DKK2	ENSP00000285311⁴	STRING: ENSP00000285311
KREMEN1	ENSP00000331242⁴	STRING: ENSP00000331242
LRP5	ENSP00000294304⁴	STRING: ENSP00000294304

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016055	Wnt signaling pathway	IEA	--

KREMEN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KREMEN2 (KREM2)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KREMEN2 gene (6 alternative transcripts):

NM_001253725.1 NM_001253726.1 NM_024507.3 NM_172229.2 NM_145347.1 NM_145348.1

Unigene Cluster for KREMEN2:

Kringle containing transmembrane protein 2

Hs.661128 [show with all ESTs]

Unigene Representative Sequence: BC009383

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303746(uc002csg.3 uc010uwl.2 uc002csh.3 uc010bsx.3)

ENST00000572045(uc010bsw.2 uc002csi.3) ENST00000575885 ENST00000571007

ENST00000319500 ENST00000575769

miRNA Products:		Block miRNA regulation of human, mouse, rat KREMEN2 using miScript Target Protectors
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		GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KREMEN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat KREMEN2
		QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
		QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

Additional mRNA sequence:

AB086355.1 AB086356.1 AB086357.1 AB086405.1 AK027669.1 AK075033.1 AK223422.1 AK301953.1

BC003533.1 BC009383.2

9 DOTS entries:

DT.97844316 DT.100779022 DT.95261162 DT.100025471 DT.95261161 DT.91655832 DT.100779023 DT.100709448

DT.120674095

Selected AceView cDNA sequences (see all 87):

AK075033 NM_172229 CR601297 BM784186 BX394026 BM783648 BM784393 AB086357

AB086405 BM783496 AK027669 NM_145348 BM784263 BM741846 BQ638144 BC003533

BM784098 BM743015 NM_024507 BM784114 AL542353 AB086355 BQ962982 BM744460

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9
SP1:															-								-		-
SP2:																							-		-
SP3:
SP4:

ECgene alternative splicing isoforms for KREMEN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KREMEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACCTGTATG

About this image

KREMEN2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KREMEN2 Protein Expression

Genevestigator expression for KREMEN2

SOURCE GeneReport for Unigene cluster: Hs.661128

Custom PCR Arrays for KREMEN2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KREMEN2 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kremen2^{1 , 5}	kringle containing transmembrane protein 2^{1, 5}	84.12(n)¹ 88.26(a)¹		17 (12.03 cM)⁵ 73016¹ NM_028416.2¹ NP_082692.1¹ 23741200⁵
lizard (Anolis carolinensis)	Reptilia	KREMEN2⁶	kringle containing transmembrane protein 2	47(a)	1 ↔ 1	GL343287.1(1160107-1202961)

ENSEMBL Gene Tree for KREMEN2 (if available)
TreeFam Gene Tree for KREMEN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KREMEN2 gene

KREMEN1²

3 SIMAP similar genes for KREMEN2 using alignment to 1 protein entry: KREM2_HUMAN:

KREMEN1 APOA LPAL2

KREMEN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs731720^1,2	C,F,A	--	3012309(+)	`TCCCCT/CCTCGC`	4	--	us2k¹		11		NA WA CSA EA	373
rs731721^1,2	C,F,H	--	3012331(+)	`AGGGCA/TGACAT`	4	--	us2k¹		10		NS EA NA WA	782
rs137989021^1,2		--	3012361(+)	`TGAGTA/GCCAAA`	4	--	us2k¹		0	--	--	--	--
rs731722^1,2	C,F,H	--	3012384(+)	`GGTGGG/AGGGTG`	4	--	us2k¹		8		NA EA NS WA	784
rs193234521^1,2		--	3012413(+)	`GTTTCC/TGTGAG`	4	--	us2k¹		0	--	--	--	--
rs79723444^1,2	C,F	--	3012565(+)	`CAGTGC/ACAGGG`	4	--	us2k¹		1		WA	118
rs141964016^1,2		--	3012579(+)	`GAGGGA/GCGGTT`	4	--	us2k¹		0	--	--	--	--
rs28629321^1,2	C,F	--	3012659(+)	`CGCACA/GGAGTC`	4	--	us2k¹		3		WA	122
rs184545205^1,2		--	3012681(+)	`CTGTCA/GCCACC`	4	--	us2k¹		0	--	--	--	--
rs12446896^1,2	H	--	3012740(+)	`CACCGC/GCATTG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for KREMEN2 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
nsv509588	CNV	Insertion	20534489
nsv510673	CNV	Loss	20534489
nsv905170	CNV	Loss	21882294
nsv905185	CNV	Loss	21882294
dgv2575n71	CNV	Loss	21882294
dgv2576n71	CNV	Loss	21882294
dgv2578n71	CNV	Loss	21882294
dgv2577n71	CNV	Loss	21882294
nsv433167	CNV	Loss	18776910
nsv905162	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KREMEN2

DNA2.0 Custom Variant and Variant Library Synthesis for KREMEN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609899 OMIM disorders: --

1 disease for KREMEN2: About MalaCards

myeloma

KREMEN2 for disorders About GeneDecksing

Export disorders for KREMEN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KREMEN2 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with KREMEN2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)^{1, 3} Mao B....Niehrs C. (Nature 2002)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)¹ Dun X....Hou J. (Mol. Cancer 2010)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (DNA Res. 2005)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (Nature 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (Gene 1994)
(PubMed id )²

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79412	HGNC: 18797	AceView: KREMEN2	Ensembl:ENSG00000131650	euGenes: HUgn79412
ECgene: KREMEN2	H-InvDB: KREMEN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KREMEN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KREMEN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KREMEN2 gene:
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KREMEN2 Gene

Kringle Containing Transmembrane Protein 2

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Kringle Containing Transmembrane Protein 2

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