Aliases for KREMEN2 Gene
External Ids for KREMEN2 Gene
Previous GeneCards Identifiers for KREMEN2 Gene
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for KREMEN2 Gene
KREMEN2 (Kringle Containing Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Presenilin action in Notch and Wnt signaling and Signaling by GPCR. An important paralog of this gene is KREMEN1.
UniProtKB/Swiss-Prot for KREMEN2 Gene
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).