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Aliases for KREMEN2 Gene

Aliases for KREMEN2 Gene

  • Kringle Containing Transmembrane Protein 2 2 3
  • KRM2 3 4 6
  • Kringle-Containing Protein Marking The Eye And The Nose 3 4
  • Kringle Domain-Containing Transmembrane Protein 2 3 4
  • Dickkopf Receptor 2 3 4
  • Kremen Protein 2 3

External Ids for KREMEN2 Gene

Previous GeneCards Identifiers for KREMEN2 Gene

  • GC16P003034
  • GC16P003014
  • GC16P002954
  • GC16P002986

Summaries for KREMEN2 Gene

Entrez Gene Summary for KREMEN2 Gene

  • This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for KREMEN2 Gene

KREMEN2 (Kringle Containing Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Wnt signaling network and WNT Signaling. An important paralog of this gene is KREMEN1.

UniProtKB/Swiss-Prot for KREMEN2 Gene

  • Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KREMEN2 Gene

Genomics for KREMEN2 Gene

Regulatory Elements for KREMEN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KREMEN2 Gene

2,963,944 bp from pter
2,968,383 bp from pter
4,440 bases
Plus strand

Genomic View for KREMEN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KREMEN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KREMEN2 Gene

Proteins for KREMEN2 Gene

  • Protein details for KREMEN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kremen protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DXF6
    • I3L2S2
    • Q8N2J4
    • Q8NCW1
    • Q96GL8
    • Q9BTP9

    Protein attributes for KREMEN2 Gene

    462 amino acids
    Molecular mass:
    48849 Da
    Quaternary structure:
    • Interacts with ERLEC1.

    Alternative splice isoforms for KREMEN2 Gene

neXtProt entry for KREMEN2 Gene

Proteomics data for KREMEN2 Gene at MOPED

Post-translational modifications for KREMEN2 Gene

  • Glycosylation at Asn49, Asn222, Asn244, and Asn351
  • Modification sites at PhosphoSitePlus

Other Protein References for KREMEN2 Gene

No data available for DME Specific Peptides for KREMEN2 Gene

Domains for KREMEN2 Gene

Protein Domains for KREMEN2 Gene

Suggested Antigen Peptide Sequences for KREMEN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NCW0
  • Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain.
  • Contains 1 CUB domain.
  • Contains 1 kringle domain.
  • Contains 1 WSC domain.
genes like me logo Genes that share domains with KREMEN2: view

No data available for Gene Families for KREMEN2 Gene

Function for KREMEN2 Gene

Molecular function for KREMEN2 Gene

UniProtKB/Swiss-Prot Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).

Gene Ontology (GO) - Molecular Function for KREMEN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KREMEN2: view
genes like me logo Genes that share phenotypes with KREMEN2: view

Animal Models for KREMEN2 Gene

MGI Knock Outs for KREMEN2:

Animal Model Products

CRISPR Products

miRNA for KREMEN2 Gene

miRTarBase miRNAs that target KREMEN2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KREMEN2 Gene

Localization for KREMEN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KREMEN2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for KREMEN2 Gene COMPARTMENTS Subcellular localization image for KREMEN2 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for KREMEN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with KREMEN2: view

Pathways for KREMEN2 Gene

genes like me logo Genes that share pathways with KREMEN2: view

Pathways by source for KREMEN2 Gene

1 Qiagen pathway for KREMEN2 Gene

Gene Ontology (GO) - Biological Process for KREMEN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007154 cell communication IBA --
GO:0016055 Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS --
genes like me logo Genes that share ontologies with KREMEN2: view

Transcripts for KREMEN2 Gene

Unigene Clusters for KREMEN2 Gene

Kringle containing transmembrane protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KREMEN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KREMEN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -

Relevant External Links for KREMEN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KREMEN2 Gene

mRNA expression in normal human tissues for KREMEN2 Gene

mRNA differential expression in normal tissues according to GTEx for KREMEN2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (9.4), Skin - Sun Exposed (Lower leg) (7.5), and Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KREMEN2 Gene

SOURCE GeneReport for Unigene cluster for KREMEN2 Gene Hs.661128

genes like me logo Genes that share expressions with KREMEN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KREMEN2 Gene

Orthologs for KREMEN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KREMEN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KREMEN2 36
  • 99 (a)
(Bos Taurus)
Mammalia KREMEN2 36
  • 72 (a)
(Canis familiaris)
Mammalia KREMEN2 35
  • 90.15 (n)
  • 91.73 (a)
  • 90 (a)
(Mus musculus)
Mammalia Kremen2 35
  • 84.12 (n)
  • 88.26 (a)
Kremen2 16
Kremen2 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia KREMEN2 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Kremen2 35
  • 84.27 (n)
  • 88.03 (a)
(Anolis carolinensis)
Reptilia KREMEN2 36
  • 47 (a)
Species with no ortholog for KREMEN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KREMEN2 Gene

Gene Tree for KREMEN2 (if available)
Gene Tree for KREMEN2 (if available)

Paralogs for KREMEN2 Gene

Paralogs for KREMEN2 Gene

Selected SIMAP similar genes for KREMEN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KREMEN2: view

Variants for KREMEN2 Gene

Sequence variations from dbSNP and Humsavar for KREMEN2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs731720 -- 2,962,308(+) TCCCC(C/T)CTCGC upstream-variant-2KB
rs731721 -- 2,962,330(+) AGGGC(A/T)GACAT upstream-variant-2KB
rs731722 -- 2,962,383(+) GGTGG(A/G)GGGTG upstream-variant-2KB
rs757275 -- 2,962,745(+) CATTG(C/T)GCAGG upstream-variant-2KB
rs1076231 -- 2,964,411(-) AGTCT(C/G)CCCTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KREMEN2 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
nsv433167 CNV Loss 18776910
dgv2578n71 CNV Loss 21882294
nsv827525 CNV Gain 20364138

Relevant External Links for KREMEN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KREMEN2 Gene

Disorders for KREMEN2 Gene

No disorders were found for KREMEN2 Gene.

No data available for UniProtKB/Swiss-Prot for KREMEN2 Gene

Publications for KREMEN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PMID: 12050670) Mao B. … Niehrs C. (Nature 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for KREMEN2 Gene

Sources for KREMEN2 Gene

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