Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KREMEN2 Gene

protein-coding GIFtS: 51
GCID: GC16P002986

Kringle Containing Transmembrane Protein 2

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Kringle Containing Transmembrane Protein 2¹ ²
KRM2² ³ ⁵
Dickkopf Receptor 2² ³
Kringle Domain-Containing Transmembrane Protein 2² ³
Kringle-Containing Protein Marking The Eye And The Nose² ³
Kremen Protein 2²

External Ids:	HGNC: 18797¹	Entrez Gene: 79412²	Ensembl: ENSG00000131650⁷	OMIM: 609899⁵	UniProtKB: Q8NCW0³

Export aliases for KREMEN2 gene to outside databases

Previous GC identifers: GC16P003034 GC16P003014 GC16P002954

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KREMEN2 Gene:

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse

functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a

ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and

induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC,

and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this

gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for KREMEN2 Gene:

KREMEN2 (kringle containing transmembrane protein 2) is a protein-coding gene. Diseases associated with KREMEN2 include myeloma. An important paralog of this gene is KREMEN1.

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a

ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the

plasma membrane (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.2 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KREMEN2 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F NRSF form 1 E2F-2 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KREMEN2 promoter sequence

Search SABiosciences Chromatin IP Primers for KREMEN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KREMEN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.11

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P002986: view genomic region (about GC identifiers)

Start:	3,013,945 bp from pter	End:	3,018,384 bp from pter
Size:	4,440 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0 (See protein sequence)

Recommended Name: Kremen protein 2 precursor

Size: 462 amino acids; 48849 Da

Subunit: Interacts with ERLEC1 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: B4DXF6 I3L2S2 Q8N2J4 Q8NCW1 Q96GL8 Q9BTP9

Alternative splicing: 6 isoforms: Q8NCW0-1 Q8NCW0-2 Q8NCW0-3 Q8NCW0-4 Q8NCW0-5 Q8NCW0-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

Explore proteomics data for KREMEN2 at MOPED

KREMEN2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001240654.1 NP_001240655.1 NP_078783.1 NP_757384.1

ENSEMBL proteins:

ENSP00000304422 ENSP00000460578 ENSP00000459878 ENSP00000461860 ENSP00000322079

ENSP00000460917

Human Recombinant Protein Products for KREMEN2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KREMEN2 (Kremen-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for KREMEN2 OriGene Protein Over-expression Lysate for KREMEN2 OriGene MassSpec for KREMEN2 OriGene Custom Protein Services for KREMEN2
	GenScript Custom Purified and Recombinant Proteins Services for KREMEN2
	Novus Biologicals KREMEN2 Proteins Novus Biologicals KREMEN2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for KREMEN2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

KREMEN2 for ontologies About GeneDecksing

KREMEN2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KREMEN2 (Kremen-2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for KREMEN2
	GenScript Custom Superior Antibodies Services for KREMEN2
	Novus Biologicals KREMEN2 Antibodies
	Abcam antibodies for KREMEN2
	Cloud-Clone Corp. Antibodies for KREMEN2
	ThermoFisher Antibodies for KREMEN2
	LSBio Antibodies in human, mouse, rat for KREMEN2

Assay Products for KREMEN2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KREMEN2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KREMEN2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KREMEN2 Cloud-Clone Corp. CLIAs for KREMEN2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/6 InterPro protein domains (see all 6):

IPR000859 CUB_dom

IPR000001 Kringle

IPR002889 WSC_carb-bd

IPR013806 Kringle-like

IPR018056 Kringle_CS

Graphical View of Domain Structure for InterPro Entry Q8NCW0

ProtoNet protein and cluster: Q8NCW0

3 Blocks protein domains:

IPB000001 Kringle

IPB000859 CUB domain

IPB002889 Carbohydrate-binding WSC

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0

Domain: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)

Similarity: Contains 1 CUB domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 WSC domain

KREMEN2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KREM2_HUMAN, Q8NCW0

Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a

ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the

plasma membrane (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

KREMEN2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kremen2):

limbs/digits/tail

normal

reproductive system

skeleton

KREMEN2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Kremen2^tm1Cni for KREMEN2

inGenious Targeting Laboratory - Custom generated mouse model solutions for KREMEN2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KREMEN2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KREMEN2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KREMEN2

miRNA Products:		miRTarBase miRNAs that target KREMEN2: hsa-mir-29a (MIRT004564)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KREMEN2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KREMEN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KREMEN2
			Sirion Biotech Customized adenovirus for overexpression of KREMEN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for KREMEN2 (see all 11) OriGene ORF clones in mouse, rat for KREMEN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KREMEN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2
		Sirion Biotech Customized lentivirus for stable overexpression of KREMEN2 Customized lentivirus expression plasmids for stable overexpression of KREMEN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KREMEN2
		Search LifeMap BioReagents cell lines for KREMEN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KREMEN2 About

See pathways by source

SuperPath

Contained pathways About

Wnt signaling network

Wnt signaling network

Presenilin action in Notch and Wnt signaling

Presenilin action in Notch and Wnt signaling

WNT Signaling

WNT Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KREMEN2

WNT Signaling

2 BioSystems Pathways for KREMEN2

	Presenilin action in Notch and Wnt signaling
	Wnt signaling network

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KREMEN2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for KREMEN2 (Q8NCW0³ ENSP00000304422⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRP6	O75581³, ENSP00000261349⁴	I2D: score=1 STRING: ENSP00000261349
DKK1	ENSP00000363081⁴	STRING: ENSP00000363081
DKK2	ENSP00000285311⁴	STRING: ENSP00000285311
KREMEN1	ENSP00000331242⁴	STRING: ENSP00000331242
LRP5	ENSP00000294304⁴	STRING: ENSP00000294304

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016055	Wnt receptor signaling pathway	IEA	--

KREMEN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KREMEN2 (KREM2)

Search CenterWatch for drugs/clinical trials and news about KREMEN2 / KREM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KREMEN2 gene (6 alternative transcripts):

NM_001253725.1 NM_001253726.1 NM_024507.3 NM_172229.2 NM_145347.1 NM_145348.1

Unigene Cluster for KREMEN2:

Kringle containing transmembrane protein 2

Hs.661128 [show with all ESTs]

Unigene Representative Sequence: BC009383

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303746(uc002csg.3 uc010uwl.2 uc002csh.3 uc010bsx.3)

ENST00000572045(uc010bsw.2 uc002csi.3) ENST00000575885 ENST00000571007

ENST00000319500 ENST00000575769

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KREMEN2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: KREMEN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for KREMEN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2

Clone Products:		OriGene clones in human, mouse for KREMEN2 (see all 11) OriGene ORF clones in mouse, rat for KREMEN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KREMEN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2
		Sirion Biotech Customized lentivirus for stable overexpression of KREMEN2 Customized lentivirus expression plasmids for stable overexpression of KREMEN2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KREMEN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

Additional mRNA sequence:

AB086355.1 AB086356.1 AB086357.1 AB086405.1 AK027669.1 AK075033.1 AK223422.1 AK301953.1

BC003533.1 BC009383.2

9 DOTS entries:

DT.97844316 DT.100779022 DT.95261162 DT.100025471 DT.95261161 DT.91655832 DT.100779023 DT.100709448

DT.120674095

24/87 AceView cDNA sequences (see all 87):

AK075033 AI283706 BM784156 BQ185819 BM784320 AL542353 AB086356 AB086355

BM744460 AB086405 BM783648 BM743015 BE378841 BC009383 AK027669 BM784133

BM784098 BM783496 CR601297 NM_024507 BQ962982 BQ638144 BM784114 BC003533

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9
SP1:															-								-		-
SP2:																							-		-
SP3:
SP4:

ECgene alternative splicing isoforms for KREMEN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KREMEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACCTGTATG

About this image

See KREMEN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KREMEN2

SOURCE GeneReport for Unigene cluster: Hs.661128

SABiosciences Custom PCR Arrays for KREMEN2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KREMEN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KREMEN2 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kremen2^{1 , 5}	kringle containing transmembrane protein 2^{1, 5}	84.38(n)¹ 87.64(a)¹		17 (12.03 cM)⁵ 73016¹ NM_028416.2¹ NP_082692.1¹ 23741200⁵
lizard (Anolis carolinensis)	Reptilia	KREMEN2⁶	Uncharacterized protein	47(a)	1 ↔ 1	GL343287.1(1160107-1202961)
fruit fly (Drosophila melanogaster)	Insecta	mas⁶	masquerade	8(a)	1 → many	3L(4161666-4167464)

ENSEMBL Gene Tree for KREMEN2 (if available)
TreeFam Gene Tree for KREMEN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KREMEN2 gene

KREMEN1²

3 SIMAP similar genes for KREMEN2 using alignment to 1 protein entry: KREM2_HUMAN:

KREMEN1 APOA LPAL2

KREMEN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_059691⁴		--	--	see VAR_059691	2	A P	mis⁴		0	--	--	--	--
rs731720^1,2	C,F,A	--	3012309(+)	`TCCCCT/CCTCGC`	4	--	us2k¹		11		NA WA CSA EA	373
rs731721^1,2	C,F,H	--	3012331(+)	`AGGGCA/TGACAT`	4	--	us2k¹		10		NS EA NA WA	782
rs137989021^1,2		--	3012361(+)	`TGAGTA/GCCAAA`	4	--	us2k¹		0	--	--	--	--
rs731722^1,2	C,F,H	--	3012384(+)	`GGTGGG/AGGGTG`	4	--	us2k¹		8		NA EA NS WA	784
rs193234521^1,2		--	3012413(+)	`GTTTCC/TGTGAG`	4	--	us2k¹		0	--	--	--	--
rs79723444^1,2	C,F	--	3012565(+)	`CAGTGC/ACAGGG`	4	--	us2k¹		1		WA	118
rs141964016^1,2		--	3012579(+)	`GAGGGA/GCGGTT`	4	--	us2k¹		0	--	--	--	--
rs28629321^1,2	C,F	--	3012659(+)	`CGCACA/GGAGTC`	4	--	us2k¹		3		WA	122
rs184545205^1,2		--	3012681(+)	`CTGTCA/GCCACC`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for KREMEN2 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
nsv509588	CNV	Insertion	20534489
nsv510673	CNV	Loss	20534489
nsv905170	CNV	Loss	21882294
nsv905185	CNV	Loss	21882294
dgv2575n71	CNV	Loss	21882294
dgv2576n71	CNV	Loss	21882294
dgv2578n71	CNV	Loss	21882294
dgv2577n71	CNV	Loss	21882294
nsv433167	CNV	Loss	18776910
nsv905162	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing KREMEN2

DNA2.0 Custom Variant and Variant Library Synthesis for KREMEN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609899 OMIM disorders: --

2 diseases for KREMEN2: About MalaCards

myeloma

KREMEN2 for disorders About GeneDecksing

Export disorders for KREMEN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KREMEN2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KREMEN2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)^{1, 3} Mao B....Niehrs C. (2002)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)¹ Dun X....Hou J. (2010)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79412	HGNC: 18797	AceView: KREMEN2	Ensembl:ENSG00000131650	euGenes: HUgn79412
ECgene: KREMEN2	H-InvDB: KREMEN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KREMEN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KREMEN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KREMEN2 gene:
Search GeneIP for patents involving KREMEN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for KREMEN2 (Kremen-2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for KREMEN2 (Kremen-2)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for KREMEN2
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for KREMEN2
	OriGene MassSpec something-or-other for KREMEN2		OriGene clones in human, mouse for KREMEN2
	OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2		OriGene Purified Protein for KREMEN2
	OriGene ORF clones in mouse, rat for KREMEN2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KREMEN2		OriGene Custom Protein Services for KREMEN2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KREMEN2
	QIAGEN SeqTarget long-range PCR primers for resequencing KREMEN2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KREMEN2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2

	GenScript Custom Purified and Recombinant Proteins Services for KREMEN2		GenScript cDNA clones with any tag delivered in your preferred vector for KREMEN2
	GenScript Custom Assay Services for KREMEN2		GenScript Custom Superior Antibodies Services for KREMEN2
	GenScript Custom overexpressing Cell Line Services for KREMEN2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KREMEN2 promoter
	Search Chromatin IP Primers for KREMEN2
	RT² qPCR Primer Assay in human, mouse, rat KREMEN2
	GNC Network for KREMEN2
	SABiosciences PCR Arrays including human, mouse, rat KREMEN2

Search Tocris compounds for KREMEN2 (KREM2)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KREMEN2 antibodies
	KREMEN2 proteins
	KREMEN2 lysates

	Antibodies for KREMEN2
	See all of Abcam's Antibodies, Kits and Proteins for KREMEN2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for KREMEN2
	Antibodies for KREMEN2
	ELISAs for KREMEN2
	CLIAs for KREMEN2

Search LifeMap BioReagents cell lines for KREMEN2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

	SwitchGear 3'UTR luciferase reporter plasmids for KREMEN2
	SwitchGear Promoter luciferase reporter plasmids for KREMEN2

ThermoFisher Antibodies for KREMEN2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for KREMEN2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KREMEN2

Customized:

	lentivirus for stable overexpression of KREMEN2
	lentivirus expression plasmids for stable overexpression of KREMEN2
	adenovirus for overexpression of KREMEN2

LSBio Antibodies in human, mouse, rat for KREMEN2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KREMEN2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

KREMEN2 Gene

Kringle Containing Transmembrane Protein 2

Aliases
for KREMEN2 gene

Summaries
for KREMEN2 gene

Genomic Views
for KREMEN2 gene

Proteins
for KREMEN2 gene

Protein Domains /
Families
for KREMEN2 gene

Function
for KREMEN2 gene

Pathways & Interactions
for KREMEN2 gene

Drugs & Compounds
for KREMEN2 gene

Transcripts
for KREMEN2 gene

Expression
for KREMEN2 gene

Orthologs
for KREMEN2 gene

Paralogs
for KREMEN2 gene

Genomic Variants
for KREMEN2 gene

Disorders / Diseases
for KREMEN2 gene

Publications
for KREMEN2 gene

External Searches for KREMEN2 gene

Genome Databases showing KREMEN2 gene

Other Databases showing KREMEN2 gene

Specialized Databases showing KREMEN2 gene

Intellectual Property
for KREMEN2 gene

Products
for KREMEN2 gene

View Random Gene

Advanced Search

Export list of displayed genes

KREMEN2 Gene

Kringle Containing Transmembrane Protein 2

Aliasesfor KREMEN2 gene

Summariesfor KREMEN2 gene

Genomic Viewsfor KREMEN2 gene

Proteinsfor KREMEN2 gene

Protein Domains /Familiesfor KREMEN2 gene

Functionfor KREMEN2 gene

Pathways & Interactionsfor KREMEN2 gene

Drugs & Compoundsfor KREMEN2 gene

Transcriptsfor KREMEN2 gene

Expression for KREMEN2 gene

Orthologsfor KREMEN2 gene

Paralogsfor KREMEN2 gene

Genomic Variantsfor KREMEN2 gene

Disorders / Diseasesfor KREMEN2 gene

Publicationsfor KREMEN2 gene

External Searches for KREMEN2 gene

Genome Databases showing KREMEN2 gene

Other Databases showing KREMEN2 gene

Specialized Databases showing KREMEN2 gene

Intellectual Propertyfor KREMEN2 gene

Productsfor KREMEN2 gene

View Random Gene

Aliases
for KREMEN2 gene

Summaries
for KREMEN2 gene

Genomic Views
for KREMEN2 gene

Proteins
for KREMEN2 gene

Protein Domains /
Families
for KREMEN2 gene

Function
for KREMEN2 gene

Pathways & Interactions
for KREMEN2 gene

Drugs & Compounds
for KREMEN2 gene

Transcripts
for KREMEN2 gene

Expression
for KREMEN2 gene

Orthologs
for KREMEN2 gene

Paralogs
for KREMEN2 gene

Genomic Variants
for KREMEN2 gene

Disorders / Diseases
for KREMEN2 gene

Publications
for KREMEN2 gene

Intellectual Property
for KREMEN2 gene

Products
for KREMEN2 gene