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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KREMEN2 Gene

protein-coding   GIFtS: 51
GCID: GC16P002986

Kringle Containing Transmembrane Protein 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kringle Containing Transmembrane Protein 21 2
KRM22 3 5
Dickkopf Receptor 22 3
Kringle Domain-Containing Transmembrane Protein 22 3
Kringle-Containing Protein Marking The Eye And The Nose2 3
Kremen Protein 22

External Ids:    HGNC: 187971   Entrez Gene: 794122   Ensembl: ENSG000001316507   OMIM: 6098995   UniProtKB: Q8NCW03   

Export aliases for KREMEN2 gene to outside databases

Previous GC identifers: GC16P003034 GC16P003014 GC16P002954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KREMEN2 Gene:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse
functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a
ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and
induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC,
and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this
gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for KREMEN2 Gene: 
KREMEN2 (kringle containing transmembrane protein 2) is a protein-coding gene. Diseases associated with KREMEN2 include myeloma. An important paralog of this gene is KREMEN1.

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0
Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a
ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the
plasma membrane (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KREMEN2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   NRSF form 1   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKREMEN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KREMEN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KREMEN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.11

KREMEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002986:  view genomic region     (about GC identifiers)

Start:
3,013,945 bp from pter      End:
3,018,384 bp from pter
Size:
4,440 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0 (See protein sequence)
Recommended Name: Kremen protein 2 precursor  
Size: 462 amino acids; 48849 Da
Subunit: Interacts with ERLEC1 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B4DXF6 I3L2S2 Q8N2J4 Q8NCW1 Q96GL8 Q9BTP9
Alternative splicing: 6 isoforms:  Q8NCW0-1   Q8NCW0-2   Q8NCW0-3   Q8NCW0-4   Q8NCW0-5   Q8NCW0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KREMEN2: NX_Q8NCW0

Explore proteomics data for KREMEN2 at MOPED 

KREMEN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KREMEN2 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_001240654.1  NP_001240655.1  NP_078783.1  NP_757384.1  

ENSEMBL proteins: 
 ENSP00000304422   ENSP00000460578   ENSP00000459878   ENSP00000461860   ENSP00000322079  
 ENSP00000460917  

Human Recombinant Protein Products for KREMEN2: 
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Novus Biologicals KREMEN2 Proteins
Novus Biologicals KREMEN2 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for KREMEN2 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

KREMEN2 for ontologies           About GeneDecksing



KREMEN2 Antibody Products: 
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Cloud-Clone Corp. CLIAs for KREMEN2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/6 InterPro protein domains (see all 6):
 IPR000859 CUB_dom
 IPR000001 Kringle
 IPR002889 WSC_carb-bd
 IPR013806 Kringle-like
 IPR018056 Kringle_CS

Graphical View of Domain Structure for InterPro Entry Q8NCW0

ProtoNet protein and cluster: Q8NCW0

3 Blocks protein domains:
IPB000001 Kringle
IPB000859 CUB domain
IPB002889 Carbohydrate-binding WSC


UniProtKB/Swiss-Prot: KREM2_HUMAN, Q8NCW0
Domain: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)
Similarity: Contains 1 CUB domain
Similarity: Contains 1 kringle domain
Similarity: Contains 1 WSC domain


KREMEN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KREM2_HUMAN, Q8NCW0
Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a
ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the
plasma membrane (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
KREMEN2 for ontologies           About GeneDecksing


Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kremen2):
 limbs/digits/tail  normal  reproductive system  skeleton 

KREMEN2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Kremen2tm1Cni for KREMEN2

   inGenious Targeting Laboratory - Custom generated mouse model solutions for KREMEN2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KREMEN2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KREMEN2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KREMEN2 

miRNA
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miRTarBase miRNAs that target KREMEN2:
hsa-mir-29a (MIRT004564)

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3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
hsa-miR-29c hsa-miR-29a hsa-miR-29b
SwitchGear 3'UTR luciferase reporter plasmidKREMEN2 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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                     Customized lentivirus expression plasmids for stable overexpression of KREMEN2 

Cell Line
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Search LifeMap BioReagents cell lines for KREMEN2
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KREMEN2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Wnt signaling network
Wnt signaling network
2Presenilin action in Notch and Wnt signaling
Presenilin action in Notch and Wnt signaling
3WNT Signaling
WNT Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KREMEN2
    WNT Signaling

2 BioSystems Pathways for KREMEN2
    Presenilin action in Notch and Wnt signaling
Wnt signaling network


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KREMEN2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for KREMEN2 (Q8NCW03 ENSP000003044224) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
DKK1ENSP000003630814STRING: ENSP00000363081
DKK2ENSP000002853114STRING: ENSP00000285311
KREMEN1ENSP000003312424STRING: ENSP00000331242
LRP5ENSP000002943044STRING: ENSP00000294304
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016055Wnt receptor signaling pathway IEA--

KREMEN2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KREMEN2 (KREM2)

Search CenterWatch for drugs/clinical trials and news about KREMEN2 / KREM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KREMEN2 gene (6 alternative transcripts): 
NM_001253725.1  NM_001253726.1  NM_024507.3  NM_172229.2  NM_145347.1  NM_145348.1  

Unigene Cluster for KREMEN2:

Kringle containing transmembrane protein 2
Hs.661128  [show with all ESTs]
Unigene Representative Sequence: BC009383
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000303746(uc002csg.3 uc010uwl.2 uc002csh.3 uc010bsx.3)
ENST00000572045(uc010bsw.2 uc002csi.3) ENST00000575885 ENST00000571007
ENST00000319500 ENST00000575769
miRNA
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3 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN2:
hsa-miR-29c hsa-miR-29a hsa-miR-29b
SwitchGear 3'UTR luciferase reporter plasmidKREMEN2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KREMEN2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN2
Clone
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OriGene clones in human, mouse for KREMEN2 (see all 11)
OriGene ORF clones in mouse, rat for KREMEN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): KREMEN2 (NM_172229)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KREMEN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN2
Sirion Biotech Customized lentivirus for stable overexpression of KREMEN2 
                     Customized lentivirus expression plasmids for stable overexpression of KREMEN2 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for KREMEN2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KREMEN2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2

Additional mRNA sequence: 

AB086355.1 AB086356.1 AB086357.1 AB086405.1 AK027669.1 AK075033.1 AK223422.1 AK301953.1 
BC003533.1 BC009383.2 

9 DOTS entries:

DT.97844316  DT.100779022  DT.95261162  DT.100025471  DT.95261161  DT.91655832  DT.100779023  DT.100709448 
DT.120674095 

24/87 AceView cDNA sequences (see all 87):

AK075033 AI283706 BM784156 BQ185819 BM784320 AL542353 AB086356 AB086355 
BM744460 AB086405 BM783648 BM743015 BE378841 BC009383 AK027669 BM784133 
BM784098 BM783496 CR601297 NM_024507 BQ962982 BQ638144 BM784114 BC003533 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN2    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1:                                            -                       -     -         
SP2:                                                                    -     -         
SP3:                                                                                    
SP4:                                                                                    


ECgene alternative splicing isoforms for KREMEN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KREMEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACCTGTATG
KREMEN2 Expression
About this image


See KREMEN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KREMEN2

SOURCE GeneReport for Unigene cluster: Hs.661128
    SABiosciences Custom PCR Arrays for KREMEN2
Primer
Products:
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KREMEN2
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KREMEN2 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kremen21 , 5 kringle containing transmembrane protein 21, 5 84.38(n)1
87.64(a)1
  17 (12.03 cM)5
730161  NM_028416.21  NP_082692.11 
 237412005 
lizard
(Anolis carolinensis)
Reptilia KREMEN26
Uncharacterized protein
47(a)
1 ↔ 1
GL343287.1(1160107-1202961)
fruit fly
(Drosophila melanogaster)
Insecta mas6
masquerade
8(a)
1 → many
3L(4161666-4167464)


ENSEMBL Gene Tree for KREMEN2 (if available)
TreeFam Gene Tree for KREMEN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KREMEN2 gene
KREMEN12  
3 SIMAP similar genes for KREMEN2 using alignment to 1 protein entry:     KREM2_HUMAN:
KREMEN1    APOA    LPAL2

KREMEN2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/115 SNPs in KREMEN2 are shown (see all 115)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0596914
----see VAR_0596912 A P mis40--------
rs7317201,2
C,F,A--3012309(+) TCCCCT/CCTCGC 4 -- us2k111Minor allele frequency- C:0.43NA WA CSA EA 373
rs7317211,2
C,F,H--3012331(+) AGGGCA/TGACAT 4 -- us2k110Minor allele frequency- T:0.28NS EA NA WA 782
rs1379890211,2
--3012361(+) TGAGTA/GCCAAA 4 -- us2k10--------
rs7317221,2
C,F,H--3012384(+) GGTGGG/AGGGTG 4 -- us2k18Minor allele frequency- A:0.03NA EA NS WA 784
rs1932345211,2
--3012413(+) GTTTCC/TGTGAG 4 -- us2k10--------
rs797234441,2
C,F--3012565(+) CAGTGC/ACAGGG 4 -- us2k11Minor allele frequency- A:0.08WA 118
rs1419640161,2
--3012579(+) GAGGGA/GCGGTT 4 -- us2k10--------
rs286293211,2
C,F--3012659(+) CGCACA/GGAGTC 4 -- us2k13Minor allele frequency- G:0.23WA 122
rs1845452051,2
--3012681(+) CTGTCA/GCCACC 4 -- us2k10--------

HapMap Linkage Disequilibrium report for KREMEN2 (3013945 - 3018384 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/11 variations for KREMEN2 (see all 11):    About this table     
Variant IDTypeSubtypePubMed ID
nsv509588CNV Insertion20534489
nsv510673CNV Loss20534489
nsv905170CNV Loss21882294
nsv905185CNV Loss21882294
dgv2575n71CNV Loss21882294
dgv2576n71CNV Loss21882294
dgv2578n71CNV Loss21882294
dgv2577n71CNV Loss21882294
nsv433167CNV Loss18776910
nsv905162CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KREMEN2
DNA2.0 Custom Variant and Variant Library Synthesis for KREMEN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609899    OMIM disorders: --

2 diseases for KREMEN2:    About MalaCards
myeloma    


KREMEN2 for disorders           About GeneDecksing


Export disorders for KREMEN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KREMEN2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KREMEN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. (PubMed id 12050670)1, 3 Mao B....Niehrs C. (2002)
  4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
  5. Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. (PubMed id 20846389)1 Dun X....Hou J. (2010)
  6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
  7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79412 HGNC: 18797 AceView: KREMEN2 Ensembl:ENSG00000131650 euGenes: HUgn79412
ECgene: KREMEN2 H-InvDB: KREMEN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KREMEN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KREMEN2 gene:
Search GeneIP for patents involving KREMEN2

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