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Aliases for KREMEN1 Gene

Aliases for KREMEN1 Gene

  • Kringle Containing Transmembrane Protein 1 2 3 5
  • Kringle-Containing Protein Marking The Eye And The Nose 3 4
  • Kringle Domain-Containing Transmembrane Protein 1 3 4
  • Dickkopf Receptor 3 4
  • KREMEN 3 4
  • KRM1 3 4
  • Kringle-Coding Gene Marking The Eye And The Nose 3
  • Kringle Containing Transmembrane Protein 2
  • EC 3.4.21 63

External Ids for KREMEN1 Gene

Previous HGNC Symbols for KREMEN1 Gene


Previous GeneCards Identifiers for KREMEN1 Gene

  • GC22P026166
  • GC22P027793
  • GC22P029469
  • GC22P012433

Summaries for KREMEN1 Gene

Entrez Gene Summary for KREMEN1 Gene

  • This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KREMEN1 Gene

KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include Osteoporosis-Pseudoglioma Syndrome. Among its related pathways are Signaling by Wnt and WNT Signaling. An important paralog of this gene is KREMEN2.

UniProtKB/Swiss-Prot for KREMEN1 Gene

  • Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Gene Wiki entry for KREMEN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KREMEN1 Gene

Genomics for KREMEN1 Gene

Regulatory Elements for KREMEN1 Gene

Enhancers for KREMEN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KREMEN1 on UCSC Golden Path with GeneCards custom track

Promoters for KREMEN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KREMEN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KREMEN1 Gene

29,073,078 bp from pter
29,168,333 bp from pter
95,256 bases
Plus strand

Genomic View for KREMEN1 Gene

Genes around KREMEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KREMEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KREMEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KREMEN1 Gene

Proteins for KREMEN1 Gene

  • Protein details for KREMEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kremen protein 1
    Protein Accession:
    Secondary Accessions:
    • B0QY46
    • B0QY47
    • B1AJR5
    • Q5TIB9
    • Q6P3X6
    • Q9BY70
    • Q9UGS5
    • Q9UGU1

    Protein attributes for KREMEN1 Gene

    473 amino acids
    Molecular mass:
    51744 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KREMEN1 Gene


neXtProt entry for KREMEN1 Gene

Proteomics data for KREMEN1 Gene at MOPED

Selected DME Specific Peptides for KREMEN1 Gene

Post-translational modifications for KREMEN1 Gene

  • Glycosylation at Asn 45, Asn 59, Asn 217, Asn 293, Asn 333, and Asn 345
  • Modification sites at PhosphoSitePlus

Other Protein References for KREMEN1 Gene

Antibody Products

Domains & Families for KREMEN1 Gene

Protein Domains for KREMEN1 Gene

Suggested Antigen Peptide Sequences for KREMEN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Contains 1 CUB domain.
  • Contains 1 kringle domain.
  • Contains 1 WSC domain.
genes like me logo Genes that share domains with KREMEN1: view

No data available for Gene Families for KREMEN1 Gene

Function for KREMEN1 Gene

Molecular function for KREMEN1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Enzyme Numbers (IUBMB) for KREMEN1 Gene

genes like me logo Genes that share phenotypes with KREMEN1: view

Animal Models for KREMEN1 Gene

MGI Knock Outs for KREMEN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KREMEN1

miRNA for KREMEN1 Gene

miRTarBase miRNAs that target KREMEN1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KREMEN1 Gene

Localization for KREMEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KREMEN1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for KREMEN1 Gene COMPARTMENTS Subcellular localization image for KREMEN1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KREMEN1: view

Pathways & Interactions for KREMEN1 Gene

genes like me logo Genes that share pathways with KREMEN1: view

Interacting Proteins for KREMEN1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000331242 Q96MU8-KREM1_HUMAN for KREMEN1 Gene via STRING I2D

SIGNOR curated interactions for KREMEN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with KREMEN1: view

Drugs & Compounds for KREMEN1 Gene

No Compound Related Data Available

Transcripts for KREMEN1 Gene

Unigene Clusters for KREMEN1 Gene

Kringle containing transmembrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: -

Relevant External Links for KREMEN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KREMEN1 Gene

mRNA expression in normal human tissues for KREMEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KREMEN1 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for KREMEN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KREMEN1 Gene

SOURCE GeneReport for Unigene cluster for KREMEN1 Gene Hs.229335

genes like me logo Genes that share expression patterns with KREMEN1: view

Protein tissue co-expression partners for KREMEN1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KREMEN1 Gene

Orthologs for KREMEN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KREMEN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KREMEN1 35
  • 89.7 (n)
  • 91.27 (a)
  • 90 (a)
(Canis familiaris)
Mammalia KREMEN1 35
  • 91.04 (n)
  • 94.44 (a)
  • 94 (a)
(Mus musculus)
Mammalia Kremen1 35
  • 87.75 (n)
  • 93.1 (a)
Kremen1 16
Kremen1 36
  • 93 (a)
(Pan troglodytes)
Mammalia KREMEN1 35
  • 99.8 (n)
  • 99.59 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Kremen1 35
  • 88.05 (n)
  • 92.43 (a)
(Monodelphis domestica)
Mammalia KREMEN1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia KREMEN1 36
  • 84 (a)
(Gallus gallus)
Aves KREMEN1 35
  • 71.88 (n)
  • 75.83 (a)
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kremen1 35
  • 69.44 (n)
  • 70.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia kremen 35
(Danio rerio)
Actinopterygii kremen1 35
  • 62.5 (n)
  • 62.26 (a)
kremen1 36
  • 58 (a)
Species with no ortholog for KREMEN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KREMEN1 Gene

Gene Tree for KREMEN1 (if available)
Gene Tree for KREMEN1 (if available)

Paralogs for KREMEN1 Gene

Paralogs for KREMEN1 Gene

(3) SIMAP similar genes for KREMEN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KREMEN1: view

Variants for KREMEN1 Gene

Sequence variations from dbSNP and Humsavar for KREMEN1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs20037 -- 29,081,853(+) AGTTT(G/T)ACTTT intron-variant
rs126077 -- 29,106,740(+) ATTCC(A/G)GCTAC intron-variant
rs132265 -- 29,120,118(+) gagga(A/G)ggaga intron-variant
rs132266 -- 29,120,128(+) aggtg(A/C)tgatg intron-variant
rs132267 -- 29,120,132(+) GATGA(A/C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KREMEN1 Gene

Variant ID Type Subtype PubMed ID
nsv524259 CNV Loss 19592680
nsv519517 CNV Loss 19592680
esv2128713 CNV Deletion 18987734
esv24546 CNV Loss 19812545
nsv524483 CNV Loss 19592680
esv2724120 CNV Deletion 23290073
nsv817986 CNV Loss 17921354

Variation tolerance for KREMEN1 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.98; 79.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KREMEN1 Gene

Disorders for KREMEN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KREMEN1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
osteoporosis-pseudoglioma syndrome
  • oppg
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KREMEN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KREMEN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KREMEN1 Gene

Publications for KREMEN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. (PMID: 11267660) Nakamura T. … Nakamura T. (Biochim. Biophys. Acta 2001) 2 3
  3. Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. (PMID: 26206087) Causeret F. … Pierani A. (Cell Death Differ. 2016) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. (PMID: 23041840) de Rooy D.P. … van der Helm-van Mil A.H. (Ann. Rheum. Dis. 2013) 3

Products for KREMEN1 Gene

Sources for KREMEN1 Gene