Aliases for KREMEN1 Gene
External Ids for KREMEN1 Gene
Previous HGNC Symbols for KREMEN1 Gene
Previous GeneCards Identifiers for KREMEN1 Gene
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KREMEN1 Gene
KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include osteoporosis-pseudoglioma syndrome and sost-related sclerosing bone dysplasia. Among its related pathways are Wnt signaling network and WNT Signaling. An important paralog of this gene is KREMEN2.
UniProtKB/Swiss-Prot for KREMEN1 Gene
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).