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Aliases for KREMEN1 Gene

Aliases for KREMEN1 Gene

  • Kringle Containing Transmembrane Protein 1 2 3
  • KRM1 3 4 6
  • Kringle-Containing Protein Marking The Eye And The Nose 3 4
  • Kringle Domain-Containing Transmembrane Protein 1 3 4
  • Dickkopf Receptor 3 4
  • KREMEN 3 4
  • Kringle-Coding Gene Marking The Eye And The Nose 3
  • Kringle Containing Transmembrane Protein 2
  • Kremen Protein 1 3
  • EC 3.4.21 64
  • KREMEM1 6

External Ids for KREMEN1 Gene

Previous Symbols for KREMEN1 Gene

  • KREMEN

Summaries for KREMEN1 Gene

Entrez Gene Summary for KREMEN1 Gene

  • This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KREMEN1 Gene

KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include sost-related sclerosing bone dysplasia and osteoporosis-pseudoglioma syndrome. Among its related pathways are Wnt signaling network and WNT Signaling. An important paralog of this gene is KREMEN2.

UniProtKB/Swiss-Prot for KREMEN1 Gene

  • Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Gene Wiki entry for KREMEN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KREMEN1 Gene

Genomics for KREMEN1 Gene

Genomic Location for KREMEN1 Gene

Start:
29,073,078 bp from pter
End:
29,168,333 bp from pter
Size:
95,256 bases
Orientation:
Plus strand

Genomic View for KREMEN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KREMEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KREMEN1 Gene

Regulatory Elements for KREMEN1 Gene

Proteins for KREMEN1 Gene

  • Protein details for KREMEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MU8-KREM1_HUMAN
    Recommended name:
    Kremen protein 1
    Protein Accession:
    Q96MU8
    Secondary Accessions:
    • B0QY46
    • B0QY47
    • B1AJR5
    • Q5TIB9
    • Q6P3X6
    • Q9BY70
    • Q9UGS5
    • Q9UGU1

    Protein attributes for KREMEN1 Gene

    Size:
    473 amino acids
    Molecular mass:
    51744 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KREMEN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KREMEN1 Gene

Proteomics data for KREMEN1 Gene at MOPED

Selected DME Specific Peptides for KREMEN1 Gene

Post-translational modifications for KREMEN1 Gene

  • Glycosylation at Asn45, Asn59, Asn217, Asn293, Asn333, and Asn345

Other Protein References for KREMEN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for KREMEN1 Gene

Protein Domains for KREMEN1 Gene

UniProtKB/Swiss-Prot:

KREM1_HUMAN
Domain:
  • Contains 1 CUB domain.:
    • Q96MU8
  • Contains 1 kringle domain.:
    • Q96MU8
  • Contains 1 WSC domain.:
    • Q96MU8
genes like me logo Genes that share domains with KREMEN1: view

No data available for Gene Families for KREMEN1 Gene

Function for KREMEN1 Gene

Molecular function for KREMEN1 Gene

UniProtKB/Swiss-Prot Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Enzyme Numbers (IUBMB) for KREMEN1 Gene

Gene Ontology (GO) - Molecular Function for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17804805
genes like me logo Genes that share ontologies with KREMEN1: view
genes like me logo Genes that share phenotypes with KREMEN1: view

Animal Models for KREMEN1 Gene

MGI Knock Outs for KREMEN1:

No data available for Transcription Factor Targeting and HOMER Transcription for KREMEN1 Gene

Localization for KREMEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KREMEN1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KREMEN1 Gene COMPARTMENTS Subcellular localization image for KREMEN1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 11267660
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KREMEN1: view

Pathways for KREMEN1 Gene

SuperPathways for KREMEN1 Gene

genes like me logo Genes that share pathways with KREMEN1: view

Pathways by source for KREMEN1 Gene

1 Qiagen pathway for KREMEN1 Gene
1 BioSystems pathway for KREMEN1 Gene

Interacting Proteins for KREMEN1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331242%0d%0a9606.ENSP00000304422%0d%0a9606.ENSP00000261349%0d%0a9606.ENSP00000363081%0d%0a
Selected Interacting proteins: ENSP00000331242 Q96MU8-KREM1_HUMAN for KREMEN1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response --
GO:0007154 cell communication TAS 11267660
GO:0016055 Wnt signaling pathway IEA --
GO:0060828 regulation of canonical Wnt signaling pathway NAS 17804805
genes like me logo Genes that share ontologies with KREMEN1: view

Transcripts for KREMEN1 Gene

Unigene Clusters for KREMEN1 Gene

Kringle containing transmembrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: -
SP3:

Relevant External Links for KREMEN1 Gene

GeneLoc Exon Structure for
KREMEN1
ECgene alternative splicing isoforms for
KREMEN1

Expression for KREMEN1 Gene

mRNA expression in normal human tissues for KREMEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KREMEN1 Gene

This gene is overexpressed in Whole Blood (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KREMEN1 Gene

SOURCE GeneReport for Unigene cluster for KREMEN1 Gene Hs.229335

genes like me logo Genes that share expressions with KREMEN1: view

Orthologs for KREMEN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KREMEN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KREMEN1 36
  • 99.8 (n)
  • 99.59 (a)
KREMEN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KREMEN1 36
  • 89.7 (n)
  • 91.27 (a)
KREMEN1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KREMEN1 36
  • 91.04 (n)
  • 94.44 (a)
KREMEN1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kremen1 36
  • 87.75 (n)
  • 93.1 (a)
Kremen1 16
Kremen1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KREMEN1 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KREMEN1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kremen1 36
  • 88.05 (n)
  • 92.43 (a)
chicken
(Gallus gallus)
Aves KREMEN1 36
  • 71.88 (n)
  • 75.83 (a)
KREMEN1 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kremen 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kremen1 36
  • 69.44 (n)
  • 70.83 (a)
zebrafish
(Danio rerio)
Actinopterygii kremen1 36
  • 62.5 (n)
  • 62.26 (a)
kremen1 37
  • 58 (a)
OneToOne
Species with no ortholog for KREMEN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KREMEN1 Gene

ENSEMBL:
Gene Tree for KREMEN1 (if available)
TreeFam:
Gene Tree for KREMEN1 (if available)

Paralogs for KREMEN1 Gene

Paralogs for KREMEN1 Gene

Selected SIMAP similar genes for KREMEN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KREMEN1: view

Variants for KREMEN1 Gene

Sequence variations from dbSNP and Humsavar for KREMEN1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs20037 -- 29,081,853(+) AGTTT(G/T)ACTTT intron-variant
rs126077 -- 29,106,740(+) ATTCC(A/G)GCTAC intron-variant
rs132265 -- 29,120,118(+) gagga(A/G)ggaga intron-variant
rs132266 -- 29,120,128(+) aggtg(A/C)tgatg intron-variant
rs132267 -- 29,120,132(+) GATGA(A/C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KREMEN1 Gene

Variant ID Type Subtype PubMed ID
nsv524259 CNV Loss 19592680
nsv519517 CNV Loss 19592680
esv2128713 CNV Deletion 18987734
esv24546 CNV Loss 19812545
nsv524483 CNV Loss 19592680
esv2724120 CNV Deletion 23290073
nsv817986 CNV Loss 17921354

Relevant External Links for KREMEN1 Gene

HapMap Linkage Disequilibrium report
KREMEN1

Disorders for KREMEN1 Gene

(1) University of Copenhagen DISEASES for KREMEN1 Gene

Relevant External Links for KREMEN1

Genetic Association Database (GAD)
KREMEN1
Human Genome Epidemiology (HuGE) Navigator
KREMEN1
genes like me logo Genes that share disorders with KREMEN1: view

No data available for UniProtKB/Swiss-Prot for KREMEN1 Gene

Publications for KREMEN1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. (PMID: 11267660) Nakamura T. … Nakamura T. (Biochim. Biophys. Acta 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 49

Products for KREMEN1 Gene

Sources for KREMEN1 Gene

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