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Aliases for KREMEN1 Gene

Aliases for KREMEN1 Gene

  • Kringle Containing Transmembrane Protein 1 2 3 5
  • Kringle-Containing Protein Marking The Eye And The Nose 3 4
  • Kringle Domain-Containing Transmembrane Protein 1 3 4
  • Dickkopf Receptor 3 4
  • KREMEN 3 4
  • KRM1 3 4
  • Kringle-Coding Gene Marking The Eye And The Nose 3
  • Kringle Containing Transmembrane Protein 2
  • Kremen Protein 1 3
  • EC 3.4.21 61
  • ECTD13 3

External Ids for KREMEN1 Gene

Previous HGNC Symbols for KREMEN1 Gene


Previous GeneCards Identifiers for KREMEN1 Gene

  • GC22P026166
  • GC22P027793
  • GC22P029469
  • GC22P012433

Summaries for KREMEN1 Gene

Entrez Gene Summary for KREMEN1 Gene

  • This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KREMEN1 Gene

KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include Bone Benign Neoplasm and Osteoporosis. Among its related pathways are Signaling by Wnt and HIV Life Cycle. An important paralog of this gene is KREMEN2.

UniProtKB/Swiss-Prot for KREMEN1 Gene

  • Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Gene Wiki entry for KREMEN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KREMEN1 Gene

Genomics for KREMEN1 Gene

Regulatory Elements for KREMEN1 Gene

Enhancers for KREMEN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G029070 1.7 FANTOM5 ENCODE dbSUPER 31.7 +0.1 67 4.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 SP3 KREMEN1 ENSG00000226772 CCDC117 EMID1 XBP1 C22orf31
GH22G029083 1.5 Ensembl ENCODE dbSUPER 27.6 +11.1 11087 1.1 PKNOX1 CREB3L1 ZNF766 GLIS2 SP3 CAVIN1 TBX21 ZNF592 SMARCA4 GLIS1 KREMEN1 ENSG00000226772 RNU6-810P CCDC117 EMID1 C22orf31
GH22G029077 1.4 Ensembl ENCODE dbSUPER 28.2 +6.0 6017 3.6 PKNOX1 FEZF1 ZNF2 ZNF121 ZNF766 KLF7 CAVIN1 YY2 REST MIER2 KREMEN1 C22orf31 ENSG00000226772
GH22G029115 0.8 Ensembl ENCODE 35.1 +43.5 43535 2.2 GATAD2A CEBPA RCOR2 ZNF10 HNF4A ATF2 MAFK KREMEN1 C22orf31 RASL10A ENSG00000226772 GC22P029136
GH22G029081 1 ENCODE dbSUPER 27.7 +8.9 8941 0.9 HDAC1 KLF1 SIN3A ZNF316 GLIS2 ZNF766 ZBTB48 NFE2 PRDM10 ZNF600 KREMEN1 ENSG00000226772 RNU6-810P CCDC117 C22orf31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KREMEN1 on UCSC Golden Path with GeneCards custom track

Promoters for KREMEN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145004 322 1601 PKNOX1 SIN3A YY1 GLIS2 ZNF207 KLF7 ZNF263 SP3 SP5 REST

Genomic Location for KREMEN1 Gene

29,073,078 bp from pter
29,168,333 bp from pter
95,256 bases
Plus strand

Genomic View for KREMEN1 Gene

Genes around KREMEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KREMEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KREMEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KREMEN1 Gene

Proteins for KREMEN1 Gene

  • Protein details for KREMEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kremen protein 1
    Protein Accession:
    Secondary Accessions:
    • B0QY46
    • B0QY47
    • B1AJR5
    • Q5TIB9
    • Q6P3X6
    • Q9BY70
    • Q9UGS5
    • Q9UGU1

    Protein attributes for KREMEN1 Gene

    473 amino acids
    Molecular mass:
    51744 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KREMEN1 Gene

    Alternative splice isoforms for KREMEN1 Gene


neXtProt entry for KREMEN1 Gene

Selected DME Specific Peptides for KREMEN1 Gene


Post-translational modifications for KREMEN1 Gene

  • Glycosylation at isoforms=2, 345, isoforms=2, 359, isoforms=2, 3217, isoforms=2, 3293, isoforms=2, 3333, and isoforms=2, 3345
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for KREMEN1

Domains & Families for KREMEN1 Gene

Suggested Antigen Peptide Sequences for KREMEN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KREMEN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KREMEN1 Gene

Function for KREMEN1 Gene

Molecular function for KREMEN1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).

Enzyme Numbers (IUBMB) for KREMEN1 Gene

Gene Ontology (GO) - Molecular Function for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17804805
genes like me logo Genes that share ontologies with KREMEN1: view
genes like me logo Genes that share phenotypes with KREMEN1: view

Animal Models for KREMEN1 Gene

MGI Knock Outs for KREMEN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KREMEN1

miRNA for KREMEN1 Gene

miRTarBase miRNAs that target KREMEN1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KREMEN1 Gene

Localization for KREMEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KREMEN1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KREMEN1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 11267660
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KREMEN1: view

Pathways & Interactions for KREMEN1 Gene

genes like me logo Genes that share pathways with KREMEN1: view

SIGNOR curated interactions for KREMEN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KREMEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process ISS --
GO:0007154 cell communication TAS 11267660
GO:0016055 Wnt signaling pathway IEA --
GO:0030279 negative regulation of ossification IEA --
GO:0060173 limb development ISS --
genes like me logo Genes that share ontologies with KREMEN1: view

Drugs & Compounds for KREMEN1 Gene

No Compound Related Data Available

Transcripts for KREMEN1 Gene

Unigene Clusters for KREMEN1 Gene

Kringle containing transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: -

Relevant External Links for KREMEN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KREMEN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KREMEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KREMEN1 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for KREMEN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KREMEN1 Gene

Protein tissue co-expression partners for KREMEN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KREMEN1 Gene:


SOURCE GeneReport for Unigene cluster for KREMEN1 Gene:


Evidence on tissue expression from TISSUES for KREMEN1 Gene

  • Eye(4.2)
  • Skin(2.8)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with KREMEN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KREMEN1 Gene

Orthologs for KREMEN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KREMEN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KREMEN1 34 35
  • 99.8 (n)
(Canis familiaris)
Mammalia KREMEN1 34 35
  • 91.04 (n)
(Bos Taurus)
Mammalia KREMEN1 34 35
  • 89.7 (n)
(Rattus norvegicus)
Mammalia Kremen1 34
  • 88.05 (n)
(Mus musculus)
Mammalia Kremen1 34 16 35
  • 87.75 (n)
(Ornithorhynchus anatinus)
Mammalia KREMEN1 35
  • 84 (a)
(Monodelphis domestica)
Mammalia KREMEN1 35
  • 73 (a)
(Gallus gallus)
Aves KREMEN1 34 35
  • 71.88 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kremen1 34
  • 69.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia kremen 34
(Danio rerio)
Actinopterygii kremen1 34 35
  • 62.5 (n)
Species where no ortholog for KREMEN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KREMEN1 Gene

Gene Tree for KREMEN1 (if available)
Gene Tree for KREMEN1 (if available)

Paralogs for KREMEN1 Gene

Paralogs for KREMEN1 Gene

(3) SIMAP similar genes for KREMEN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KREMEN1: view

Variants for KREMEN1 Gene

Sequence variations from dbSNP and Humsavar for KREMEN1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000012115 -- 29,154,357(+) GGTGA(A/C)AATAC intron-variant
rs1000035348 -- 29,164,524(+) AGGCA(A/G)ATCAT intron-variant
rs1000044623 -- 29,154,107(+) ATTTT(C/T)ATCAG intron-variant
rs1000059196 -- 29,123,510(+) TAGTC(A/G)TCTGG intron-variant
rs1000077018 -- 29,112,426(+) GGAGG(G/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KREMEN1 Gene

Variant ID Type Subtype PubMed ID
esv2128713 CNV deletion 18987734
esv24546 CNV loss 19812545
esv2724120 CNV deletion 23290073
esv3385945 CNV insertion 20981092
esv3446692 CNV insertion 20981092
nsv1149728 CNV insertion 26484159
nsv1153950 CNV insertion 26484159
nsv519517 CNV loss 19592680
nsv524259 CNV loss 19592680
nsv524483 CNV loss 19592680
nsv817986 CNV loss 17921354

Variation tolerance for KREMEN1 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.98; 79.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KREMEN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KREMEN1 Gene

Disorders for KREMEN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KREMEN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bone benign neoplasm
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KREMEN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KREMEN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KREMEN1 Gene

Publications for KREMEN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KREMEN1 Gene

Sources for KREMEN1 Gene

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