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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KREMEN1 Gene

protein-coding   GIFtS: 56
GCID: GC22P029469

Kringle Containing Transmembrane Protein 1

(Previous name: kringle containing transmembrane protein)
(Previous symbol: KREMEN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kringle Containing Transmembrane Protein 11 2     Kringle Containing Transmembrane Protein1
KREMEN1 2 3     Kremen Protein 12
KRM12 3 5     Kringle-Coding Gene Marking The Eye And The Nose2
Dickkopf Receptor2 3     KREMEM15
Kringle Domain-Containing Transmembrane Protein 12 3     EC 3.4.218
Kringle-Containing Protein Marking The Eye And The Nose2 3     

External Ids:    HGNC: 175501   Entrez Gene: 839992   Ensembl: ENSG000001837627   OMIM: 6098985   UniProtKB: Q96MU83   

Export aliases for KREMEN1 gene to outside databases

Previous GC identifers: GC22P026166 GC22P027793 GC22P012433


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KREMEN1 Gene:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates
with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane
complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains
extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms
have been observed for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KREMEN1 Gene: 
KREMEN1 (kringle containing transmembrane protein 1) is a protein-coding gene. Diseases associated with KREMEN1 include osteoporosis-pseudoglioma syndrome, and sost-related sclerosing bone dysplasia. GO annotations related to this gene include protein binding. An important paralog of this gene is KREMEN2.

UniProtKB/Swiss-Prot: KREM1_HUMAN, Q96MU8
Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By
similarity)

Gene Wiki entry for KREMEN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KREMEN1 gene promoter:
         Pbx1a   SREBP-1c   Lmo2   CUTL1   SREBP-1b   FAC1   Nkx6-1   FOXC1   SREBP-1a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KREMEN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KREMEN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

KREMEN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KREMEN1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P029469:  view genomic region     (about GC identifiers)

Start:
29,469,066 bp from pter      End:
29,564,321 bp from pter
Size:
95,256 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KREM1_HUMAN, Q96MU8 (See protein sequence)
Recommended Name: Kremen protein 1 precursor  
Size: 473 amino acids; 51744 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B0QY46 B0QY47 B1AJR5 Q5TIB9 Q6P3X6 Q9BY70 Q9UGS5 Q9UGU1
Alternative splicing: 3 isoforms:  Q96MU8-1   Q96MU8-2   Q96MU8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KREMEN1: NX_Q96MU8

Explore proteomics data for KREMEN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MU8

  • 2 DME Specific Peptides for KREMEN1 (Q96MU8)
     NYCRNPD  CRNPDGD 

    KREMEN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KREMEN1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034659.2  NP_114434.3  

    ENSEMBL proteins: 
     ENSP00000383189   ENSP00000331242   ENSP00000385431   ENSP00000388228   ENSP00000383192  

    Human Recombinant Protein Products for KREMEN1: 
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    Novus Biologicals KREMEN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KREMEN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane TAS11267660
    GO:0016021integral to membrane IEA--

    KREMEN1 for ontologies           About GeneDecksing



    KREMEN1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for KREMEN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000859 CUB_dom
     IPR000001 Kringle
     IPR002889 WSC_carb-bd
     IPR013806 Kringle-like
     IPR018056 Kringle_CS

    Graphical View of Domain Structure for InterPro Entry Q96MU8

    ProtoNet protein and cluster: Q96MU8

    3 Blocks protein domains:
    IPB000001 Kringle
    IPB000859 CUB domain
    IPB002889 Carbohydrate-binding WSC


    UniProtKB/Swiss-Prot: KREM1_HUMAN, Q96MU8
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 WSC domain


    KREMEN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KREM1_HUMAN, Q96MU8
    Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By
    similarity)

         Enzyme Number (IUBMB): EC 3.4.212

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17804805
         
    KREMEN1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for KREMEN1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kremen1):
     limbs/digits/tail  normal  reproductive system  skeleton 

    KREMEN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kremen1tm1Dgen for KREMEN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KREMEN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KREMEN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KREMEN1 
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN1 (see all 92):
    hsa-miR-520f hsa-miR-3938 hsa-miR-520e hsa-miR-631 hsa-miR-30d hsa-miR-3138 hsa-miR-138-2* hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of KREMEN1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KREMEN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling network
    Wnt signaling network
    2WNT Signaling
    WNT Signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KREMEN1
        WNT Signaling

    1 BioSystems Pathway for KREMEN1
        Wnt signaling network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KREMEN1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KREMEN1 (Q96MU83 ENSP000003312424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DKK1O949073, ENSP000003630814I2D: score=1 STRING: ENSP00000363081
    KREMEN2ENSP000003044224STRING: ENSP00000304422
    LRP6ENSP000002613494STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----
    GO:0007154cell communication TAS11267660
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0060828regulation of canonical Wnt receptor signaling pathway NAS17804805

    KREMEN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KREMEN1 (KREM1)

    Search CenterWatch for drugs/clinical trials and news about KREMEN1 / KREM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KREMEN1 gene (3 alternative transcripts): 
    NM_001039570.2  NM_032045.4  NM_153379.2  

    Unigene Cluster for KREMEN1:

    Kringle containing transmembrane protein 1
    Hs.229335  [show with all ESTs]
    Unigene Representative Sequence: NM_001039570
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400335(uc003ael.3) ENST00000327813(uc011akm.1) ENST00000407188
    ENST00000453585 ENST00000474001 ENST00000479755 ENST00000400338(uc011akn.2)

    miRNA
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate KREMEN1 (see all 92):
    hsa-miR-520f hsa-miR-3938 hsa-miR-520e hsa-miR-631 hsa-miR-30d hsa-miR-3138 hsa-miR-138-2* hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KREMEN1
    Clone
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    OriGene clones in human, mouse for KREMEN1 (see all 17)
    OriGene ORF clones in mouse, rat for KREMEN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KREMEN1
    Sirion Biotech Customized lentivirus for stable overexpression of KREMEN1 
                         Customized lentivirus expression plasmids for stable overexpression of KREMEN1 
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    OriGene qPCR primer pairs and template standards for KREMEN1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KREMEN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KREMEN1

    Additional mRNA sequence: 

    AB059618.1 AK056425.1 AK172861.1 BC063787.1 

    8 DOTS entries:

    DT.86855454  DT.86859493  DT.102828624  DT.100648274  DT.308144  DT.100653664  DT.100668388  DT.91793171 

    24/112 AceView cDNA sequences (see all 112):

    NM_153379 BU101656 NM_032045 AB059618 CD633575 BM794636 BG743250 BX477602 
    BX095788 BX430917 BC063787 BM857328 BM796358 AA235330 BI791967 BM798726 
    CD724015 BF376901 AI049755 BM468254 BE828095 AA043988 BX433015 BX504135 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KREMEN1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -                                             
    SP2:                                                  -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for KREMEN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KREMEN1 expression in normal human tissues (normalized intensities)      KREMEN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAAAA
    KREMEN1 Expression
    About this image


    KREMEN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/bladder   

    See KREMEN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KREMEN1

    SOURCE GeneReport for Unigene cluster: Hs.229335
        SABiosciences Expression via Pathway-Focused PCR Array including KREMEN1: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KREMEN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KREMEN1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kremen11 , 5 kringle containing transmembrane protein 11, 5 88.16(n)1
    93.62(a)1
      11 (3.36 cM)5
    840351  NM_032396.31  NP_115772.21 
     51915525 
    chicken
    (Gallus gallus)
    Aves KREMEN11 kringle containing transmembrane protein 1 70.57(n)
    73.87(a)
      416920  XM_415211.3  XP_415211.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia kremen2 kremen protein 75.71(n)    AB070851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kremen11 kringle containing transmembrane protein 1 61.39(n)
    60.86(a)
      100141352  NM_001114917.1  NP_001108389.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mas6
    masquerade
    9(a)
    1 → many
    3L(4161666-4167464)


    ENSEMBL Gene Tree for KREMEN1 (if available)
    TreeFam Gene Tree for KREMEN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KREMEN1 gene
    KREMEN22  
    3 SIMAP similar genes for KREMEN1 using alignment to 3 protein entries:     KREM1_HUMAN (see all proteins):
    KREMEN2    APOA    LPAL2

    KREMEN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2323 SNPs in KREMEN1 are shown (see all 2323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885180981,2
    --12429914(+) TGAGCC/TGTTAA 2 -- int10--------
    rs1345831,2
    C,F,A,H--12429957(+) TTAGCC/TTCTTG 2 -- int130Minor allele frequency- T:0.37MN NS EA NA WA CSA 3318
    rs1928494551,2
    --12429966(+) TGTGCA/CCTGTT 2 -- int10--------
    rs749591391,2
    F--12430014(+) AGGTGG/AGGGTG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs1463631901,2
    --12430025(+) GAGAAA/GGTTAG 2 -- int10--------
    rs2000294841,2
    --12430079(+) ACAAA-/TTTCTG 2 -- int10--------
    rs1383457411,2
    C--12430110(+) CCATTC/TTCATG 2 -- int10--------
    rs1345851,2
    C,F,A,H--12430149(+) CCCCTT/CGCTTG 2 -- int121Minor allele frequency- C:0.41NS EA NA WA CSA 2345
    rs3708239791,2
    C--12430211(+) AAATT-/CTTTTT 2 -- int10--------
    rs1831003591,2
    --12430235(+) TGAGAC/TGGAGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for KREMEN1 (29469066 - 29564321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KREMEN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724120CNV Deletion23290073
    esv2128713CNV Deletion18987734
    esv24546CNV Loss19812545
    nsv519517CNV Loss19592680
    nsv524483CNV Loss19592680
    nsv817986CNV Loss17921354
    nsv524259CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609898    OMIM disorders: --

    4 diseases for KREMEN1:    About MalaCards
    osteoporosis-pseudoglioma syndrome    sost-related sclerosing bone dysplasia    hyperostosis    myeloma

    1 disease from the University of Copenhagen DISEASES database for KREMEN1:
    SOST-related sclerosing bone dysplasia

    KREMEN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KREMEN1
    Human Genome Epidemiology (HuGE) Navigator: KREMEN1 (6 documents)

    Export disorders for KREMEN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KREMEN1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with KREMEN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. (PubMed id 11267660)1, 3 Nakamura T....Nakamura T. (2001)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. Genetic studies on components of the Wnt signalling pa thway and the severity of joint destruction in rheumatoid arthritis. (PubMed id 23041840)1 de Rooy D.P....van der Helm-van Mil A.H. (2013)
    9. Genetic association study of KREMEN1 and DKK1 and sch izophrenia in a Japanese population. (PubMed id 20153141)1 Aleksic B....Ozaki N. (2010)
    10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83999 HGNC: 17550 AceView: KREMEN1 Ensembl:ENSG00000183762 euGenes: HUgn83999
    ECgene: KREMEN1 H-InvDB: KREMEN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KREMEN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KREMEN1 gene:
    Search GeneIP for patents involving KREMEN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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