Aliases for KREMEN1 Gene
External Ids for KREMEN1 Gene
Previous HGNC Symbols for KREMEN1 Gene
Previous GeneCards Identifiers for KREMEN1 Gene
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KREMEN1 Gene
KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include Bone Benign Neoplasm and Osteoporosis. Among its related pathways are Signaling by Wnt and HIV Life Cycle. An important paralog of this gene is KREMEN2.
UniProtKB/Swiss-Prot for KREMEN1 Gene
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).