Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRCC1 Gene

Aliases for KRCC1 Gene

  • Lysine Rich Coiled-Coil 1 2 3 5
  • Cryptogenic Hepatitis-Binding Protein 2 3 4
  • CHBP2 3 4
  • Lysine-Rich Coiled-Coil Protein 1 3

External Ids for KRCC1 Gene

Previous GeneCards Identifiers for KRCC1 Gene

  • GC02M088107
  • GC02M088326
  • GC02M087248

Summaries for KRCC1 Gene

GeneCards Summary for KRCC1 Gene

KRCC1 (Lysine Rich Coiled-Coil 1) is a Protein Coding gene. An important paralog of this gene is ZMAT1.

Additional gene information for KRCC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRCC1 Gene

Genomics for KRCC1 Gene

GeneHancer (GH) Regulatory Elements for KRCC1 Gene

Promoters and enhancers for KRCC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I088053 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 556.7 +0.3 256 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B KRCC1 THNSL2 LOC102724642 LOC730268 GC02M088051 PIR45221
GH02I088015 Promoter/Enhancer 1.6 Ensembl ENCODE 15.5 +39.1 39094 2.5 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A LOC105374852 RNU2-63P LOC102724642 LOC730268 ENSG00000231259 LOC100420889 RPIA KRCC1 EIF2AK3 THNSL2
GH02I088125 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 9.9 -73.2 -73185 6.7 FOXA2 MLX ARID4B ZNF48 ETS1 YY1 PAF1 RXRA SP5 NFYC FABP1 THNSL2 KRCC1 GC02P088146
GH02I087504 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 +542.7 542682 17.4 PKNOX1 ATF1 FOXA2 ARNT YY1 TCF12 POLR2B ATF7 CAVIN1 NCOA1 CYTOR LOC102724642 KRCC1 LOC730268 GC02M087530 LOC101928152
GH02I088022 Enhancer 0.9 ENCODE 11.8 +33.6 33584 0.2 PKNOX1 ATF1 ARNT TCF12 ATF7 NCOA1 REST KAT8 NFIL3 ATF4 KRCC1 LOC105374852 PIR45221
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRCC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRCC1 gene promoter:

Genomic Locations for KRCC1 Gene

Genomic Locations for KRCC1 Gene
chr2:88,027,203-88,055,801
(GRCh38/hg38)
Size:
28,599 bases
Orientation:
Minus strand
chr2:88,326,724-88,355,248
(GRCh37/hg19)

Genomic View for KRCC1 Gene

Genes around KRCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRCC1 Gene

Proteins for KRCC1 Gene

  • Protein details for KRCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI7-KRCC1_HUMAN
    Recommended name:
    Lysine-rich coiled-coil protein 1
    Protein Accession:
    Q9NPI7
    Secondary Accessions:
    • Q3B7J7

    Protein attributes for KRCC1 Gene

    Size:
    259 amino acids
    Molecular mass:
    30980 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07581.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305}; Sequence=ABN71577.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305};

neXtProt entry for KRCC1 Gene

Post-translational modifications for KRCC1 Gene

No Post-translational modifications

Other Protein References for KRCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRCC1 Gene

Domains & Families for KRCC1 Gene

Gene Families for KRCC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRCC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRCC1: view

No data available for UniProtKB/Swiss-Prot for KRCC1 Gene

Function for KRCC1 Gene

Phenotypes From GWAS Catalog for KRCC1 Gene

Gene Ontology (GO) - Molecular Function for KRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003723 RNA binding IBA --
genes like me logo Genes that share ontologies with KRCC1: view
genes like me logo Genes that share phenotypes with KRCC1: view

Animal Model Products

miRNA for KRCC1 Gene

miRTarBase miRNAs that target KRCC1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRCC1 Gene

Localization for KRCC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRCC1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRCC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRCC1 Gene

Pathways & Interactions for KRCC1 Gene

SuperPathways for KRCC1 Gene

No Data Available

Interacting Proteins for KRCC1 Gene

Selected Interacting proteins: Q9NPI7-KRCC1_HUMAN for KRCC1 Gene via IID

Symbol External ID(s) Details
ELAVL1
PPP1CC

Gene Ontology (GO) - Biological Process for KRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with KRCC1: view

No data available for Pathways by source and SIGNOR curated interactions for KRCC1 Gene

Drugs & Compounds for KRCC1 Gene

No Compound Related Data Available

Transcripts for KRCC1 Gene

mRNA/cDNA for KRCC1 Gene

Unigene Clusters for KRCC1 Gene

Lysine-rich coiled-coil 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for KRCC1 Gene

GeneLoc Exon Structure for
KRCC1
ECgene alternative splicing isoforms for
KRCC1

Expression for KRCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRCC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRCC1 Gene:

KRCC1

SOURCE GeneReport for Unigene cluster for KRCC1 Gene:

Hs.469254

Evidence on tissue expression from TISSUES for KRCC1 Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with KRCC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRCC1 Gene

Orthologs for KRCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRCC1 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia KRCC1 33 34
  • 87.81 (n)
dog
(Canis familiaris)
Mammalia KRCC1 33 34
  • 86.59 (n)
mouse
(Mus musculus)
Mammalia Krcc1 33 16 34
  • 83.59 (n)
Gm1070 34
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Krcc1 33
  • 82.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ZMAT1 34
  • 12 (a)
OneToMany
Species where no ortholog for KRCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRCC1 Gene

ENSEMBL:
Gene Tree for KRCC1 (if available)
TreeFam:
Gene Tree for KRCC1 (if available)

Paralogs for KRCC1 Gene

Paralogs for KRCC1 Gene

(1) SIMAP similar genes for KRCC1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KRCC1 Gene

genes like me logo Genes that share paralogs with KRCC1: view

Variants for KRCC1 Gene

Sequence variations from dbSNP and Humsavar for KRCC1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000102094 -- 88,034,875(-) T/C intron_variant
rs1000184371 -- 88,056,286(-) C/G upstream_transcript_variant
rs1000268008 -- 88,044,857(-) T/G intron_variant
rs1000291629 -- 88,048,841(-) A/G intron_variant
rs1000563946 -- 88,042,152(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRCC1 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV deletion 17901297
dgv6947n54 CNV gain 21841781
esv2720312 CNV deletion 23290073
esv2720313 CNV deletion 23290073
esv3559784 CNV deletion 23714750
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv1160817 CNV deletion 26073780
nsv441768 CNV gain 18776908
nsv582383 CNV gain 21841781
nsv582384 CNV loss 21841781
nsv582386 CNV loss 21841781
nsv955227 CNV duplication 24416366

Variation tolerance for KRCC1 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRCC1 Gene

Disorders for KRCC1 Gene

Additional Disease Information for KRCC1

No disorders were found for KRCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRCC1 Gene

Publications for KRCC1 Gene

  1. Genome-wide association meta-analysis for total serum bilirubin levels. (PMID: 19414484) Johnson AD … Witteman JC (Human molecular genetics 2009) 3 44 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M … da Cruz e Silva EF (Biochemical pharmacology 2011) 3 58
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for KRCC1 Gene

Sources for KRCC1 Gene

Content
Loading form....