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Aliases for KRCC1 Gene

Aliases for KRCC1 Gene

  • Lysine-Rich Coiled-Coil 1 2 3 5
  • Cryptogenic Hepatitis-Binding Protein 2 3 4
  • CHBP2 3 4

External Ids for KRCC1 Gene

Previous GeneCards Identifiers for KRCC1 Gene

  • GC02M088107
  • GC02M088326
  • GC02M087248

Summaries for KRCC1 Gene

GeneCards Summary for KRCC1 Gene

KRCC1 (Lysine-Rich Coiled-Coil 1) is a Protein Coding gene. An important paralog of this gene is ZNF346.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRCC1 Gene

Genomics for KRCC1 Gene

Regulatory Elements for KRCC1 Gene

Enhancers for KRCC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRCC1 on UCSC Golden Path with GeneCards custom track

Promoters for KRCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KRCC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRCC1 Gene

Chromosome:
2
Start:
88,027,203 bp from pter
End:
88,055,801 bp from pter
Size:
28,599 bases
Orientation:
Minus strand

Genomic View for KRCC1 Gene

Genes around KRCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRCC1 Gene

Proteins for KRCC1 Gene

  • Protein details for KRCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI7-KRCC1_HUMAN
    Recommended name:
    Lysine-rich coiled-coil protein 1
    Protein Accession:
    Q9NPI7
    Secondary Accessions:
    • Q3B7J7

    Protein attributes for KRCC1 Gene

    Size:
    259 amino acids
    Molecular mass:
    30980 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07581.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305}; Sequence=ABN71577.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305};

neXtProt entry for KRCC1 Gene

Proteomics data for KRCC1 Gene at MOPED

Post-translational modifications for KRCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRCC1 Gene

Domains & Families for KRCC1 Gene

Protein Domains for KRCC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRCC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRCC1 Gene

Function for KRCC1 Gene

genes like me logo Genes that share phenotypes with KRCC1: view

Animal Model Products

miRNA for KRCC1 Gene

miRTarBase miRNAs that target KRCC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRCC1 Gene

Localization for KRCC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRCC1 Gene COMPARTMENTS Subcellular localization image for KRCC1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRCC1 Gene

Pathways & Interactions for KRCC1 Gene

SuperPathways for KRCC1 Gene

No Data Available

Interacting Proteins for KRCC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340083%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000340083 for KRCC1 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for KRCC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRCC1 Gene

Drugs & Compounds for KRCC1 Gene

No Compound Related Data Available

Transcripts for KRCC1 Gene

mRNA/cDNA for KRCC1 Gene

Unigene Clusters for KRCC1 Gene

Lysine-rich coiled-coil 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for KRCC1 Gene

GeneLoc Exon Structure for
KRCC1
ECgene alternative splicing isoforms for
KRCC1

Expression for KRCC1 Gene

mRNA expression in normal human tissues for KRCC1 Gene

SOURCE GeneReport for Unigene cluster for KRCC1 Gene Hs.469254

genes like me logo Genes that share expression patterns with KRCC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRCC1 Gene

Orthologs for KRCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRCC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRCC1 35
  • 87.81 (n)
  • 80.93 (a)
KRCC1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRCC1 35
  • 86.59 (n)
  • 78.49 (a)
KRCC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krcc1 35
  • 83.59 (n)
  • 72.66 (a)
Krcc1 16
Gm1070 36
  • 32 (a)
OneToMany
Krcc1 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRCC1 35
  • 99.35 (n)
  • 98.84 (a)
KRCC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krcc1 35
  • 82.16 (n)
  • 71.87 (a)
zebrafish
(Danio rerio)
Actinopterygii ZMAT1 36
  • 12 (a)
OneToMany
Species with no ortholog for KRCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRCC1 Gene

ENSEMBL:
Gene Tree for KRCC1 (if available)
TreeFam:
Gene Tree for KRCC1 (if available)

Paralogs for KRCC1 Gene

Paralogs for KRCC1 Gene

(1) SIMAP similar genes for KRCC1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KRCC1 Gene

genes like me logo Genes that share paralogs with KRCC1: view

Variants for KRCC1 Gene

Sequence variations from dbSNP and Humsavar for KRCC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2885671 -- 88,050,378(-) CTCCT(G/T)AAGTG intron-variant
rs4972041 -- 88,052,483(+) aaatt(C/T)cttga intron-variant
rs4972167 -- 88,038,782(+) CCTTA(A/T)AAAAC intron-variant
rs4972168 -- 88,051,370(+) AAAGT(C/G)AGAGT intron-variant
rs6746682 -- 88,049,867(+) CAGAT(C/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRCC1 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV Deletion 17901297
nsv441768 CNV CNV 18776908
esv2720312 CNV Deletion 23290073
esv2720313 CNV Deletion 23290073

Variation tolerance for KRCC1 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRCC1 Gene

Disorders for KRCC1 Gene

Relevant External Links for KRCC1

Genetic Association Database (GAD)
KRCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRCC1

No disorders were found for KRCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRCC1 Gene

Publications for KRCC1 Gene

  1. Genome-wide association meta-analysis for total serum bilirubin levels. (PMID: 19414484) Johnson A.D. … Witteman J.C. (Hum. Mol. Genet. 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for KRCC1 Gene

Sources for KRCC1 Gene

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