KRCC1 Gene
protein-coding GIFtS: 40
GCID: GC02M088326
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|
lysine-rich coiled-coil 1
| |
Aliases
for KRCC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lysine-Rich Coiled-Coil 11 2 | | Cryptogenic Hepatitis-Binding Protein 22 3 | | CHBP22 3 | | FLJ223331 | | Cryptogenic Hepatitis Binding Protein2 | | Lysine-Rich Coiled-Coil Protein 12 |
Export aliases for KRCC1 gene to outside databasesPrevious GC identifers: GC02M088107 GC02M087248 |
Summaries
for KRCC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KRCC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRCC1 gene promoter:
SRF Elk-1 SRF (504 AA) Egr-1 POU6F1 (c2) MEF-2A E2F E2F-1 HOXA5 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRCC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRCC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2KRCC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M088326: view genomic region
(about GC identifiers)
Start:
|
88,326,724 bp from pter |
End:
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88,355,248 bp from pter |
Size:
|
28,525 bases |
Orientation:
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minus strand |
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Proteins
for KRCC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRCC1_HUMAN, Q9NPI7 (See
protein sequence)Recommended Name: Lysine-rich coiled-coil protein 1 Size: 259 amino acids; 30980 Da
Sequence caution: Sequence=AAI07581.1; Type=Frameshift; Positions=183; Sequence=ABN71577.1; Type=Frameshift;Positions=183;
Secondary accessions: Q3B7J7Explore the universe of human proteins at neXtProt for KRCC1: NX_Q9NPI7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPI7
KRCC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057702.1
ENSEMBL proteins: ENSP00000340083
Human Recombinant Protein Products for KRCC1:
KRCC1 Antibody Products:
Assay Products for KRCC1: |
Protein
Domains /
Families
for KRCC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NPI7 |
Function
for KRCC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KRCC1 (NM_016618) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRCC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRCC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRCC1 |
|
Pathways & Interactions
for KRCC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRCC1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KRCC1 (ENSP000003400834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRCC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRCC1
Search CenterWatch for drugs/clinical trials and news about KRCC1
|
Transcripts
for KRCC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRCC1 gene: NM_016618.1 Unigene Cluster for KRCC1: Lysine-rich coiled-coil 1 Hs.469254 [show with all ESTs]Unigene Representative Sequence: AK0259861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000347055(uc002sso.1 uc002ssp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRCC1 (NM_016618) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRCC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRCC1 |
Additional cDNA sequence: AF208845.1 AF217520.1 AK025986.1 BC015927.1 BC107580.1 EF413023.1 5 DOTS entries: DT.455679 DT.95075297 DT.101969574 DT.92015182 DT.100782851 24/178 AceView cDNA sequences (see all 178): AI677656 AA194175 AW021176 AI637999 BM512322 BX283832 AA262430 CR625257 AI638646 BE326678 AW305172 CA950151 CA427309 BM789783 AI310720 BM856194 CA306813 AF208845 BI963090 BQ084129 CR604678 BU688741 AA430106 AI041858
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KRCC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KRCC1
|
Expression
for KRCC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRCC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGCTCTCC
About this image
See KRCC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRCC1
SOURCE GeneReport for Unigene cluster: Hs.469254
SABiosciences Custom PCR Arrays for KRCC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRCC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRCC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRCC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRCC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRCC1 |
Orthologs
for KRCC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRCC1 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
36(a) |
1 → many |
6(60448618-60449397) |
ENSEMBL Gene Tree for KRCC1 (if available)
TreeFam Gene Tree for KRCC1 (if available) |
Paralogs
for KRCC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRCC1 gene
- ZNF3462 ZMAT42 ZMAT32 ZMAT12
1 SIMAP similar gene for KRCC1 using alignment to 1 protein entry: KRCC1_HUMAN:ZMAT1
KRCC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KRCC1
PGOHUM00000240138
|
Genomic Variants
for KRCC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRCC1 (88326724 - 88355248 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KRCC1
1 CNV: 37718 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRCC1 |
|
Disorders
/ Diseases
for KRCC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRCC1 for disorders About GeneDecksing
1  disease for KRCC1: About MalaCardshepatitis
Export disorders for KRCC1 gene to outside databases
|
Publications
for KRCC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRCC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRCC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1 Johnson A.D....Witteman J.C. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for KRCC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRCC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRCC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRCC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRCC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRCC1 gene:
Search GeneIP for patents involving KRCC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRCC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRCC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRCC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRCC1 | | | OriGene Protein Over-expression Lysate for KRCC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRCC1 | | OriGene 3'-UTR Clone for KRCC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRCC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KRCC1 | | OriGene Custom Protein Services for KRCC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRCC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRCC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRCC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRCC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRCC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRCC1 |
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| | | | Search Tocris compounds for KRCC1 |
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 | | | KRCC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRCC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KRCC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRCC1 |
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