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Aliases for KRBOX4 Gene

Aliases for KRBOX4 Gene

  • KRAB Box Domain Containing 4 2 3
  • KRAB Box Domain-Containing Protein 4 3 4
  • Zinc Finger Family Member 673 2 3
  • Zinc Finger Protein 673 2 3
  • ZNF673 3 4
  • Putative Zinc Finger Transcription Factor 3
  • Hypothetical Protein FLJ20344 2

External Ids for KRBOX4 Gene

Previous HGNC Symbols for KRBOX4 Gene

  • ZNF673

Previous GeneCards Identifiers for KRBOX4 Gene

  • GC0XP046307

Summaries for KRBOX4 Gene

Entrez Gene Summary for KRBOX4 Gene

  • This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for KRBOX4 Gene

KRBOX4 (KRAB Box Domain Containing 4) is a Protein Coding gene. Diseases associated with KRBOX4 include diffuse mesangial sclerosis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBOX4 Gene

Genomics for KRBOX4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRBOX4 Gene

Chromosome:
X
Start:
46,446,857 bp from pter
End:
46,497,422 bp from pter
Size:
50,566 bases
Orientation:
Plus strand

Genomic View for KRBOX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRBOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBOX4 Gene

No data available for Regulatory Elements for KRBOX4 Gene

Proteins for KRBOX4 Gene

  • Protein details for KRBOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JUW0-KRBX4_HUMAN
    Recommended name:
    KRAB domain-containing protein 4
    Protein Accession:
    Q5JUW0
    Secondary Accessions:
    • A8K0Y8
    • B3KU22
    • Q96EA3
    • Q9NXB1

    Protein attributes for KRBOX4 Gene

    Size:
    171 amino acids
    Molecular mass:
    20100 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRBOX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRBOX4 Gene

Proteomics data for KRBOX4 Gene at MOPED

Post-translational modifications for KRBOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBOX4 Gene

Domains & Families for KRBOX4 Gene

Protein Domains for KRBOX4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBOX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JUW0

UniProtKB/Swiss-Prot:

KRBX4_HUMAN :
  • Contains 1 KRAB domain.
Domain:
  • Contains 1 KRAB domain.
genes like me logo Genes that share domains with KRBOX4: view

No data available for Gene Families for KRBOX4 Gene

Function for KRBOX4 Gene

Gene Ontology (GO) - Molecular Function for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBOX4: view
genes like me logo Genes that share phenotypes with KRBOX4: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBOX4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBOX4 Gene

Localization for KRBOX4 Gene

Gene Ontology (GO) - Cellular Components for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KRBOX4 Gene

Pathways & Interactions for KRBOX4 Gene

SuperPathways for KRBOX4 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with KRBOX4: view

Pathways by source for KRBOX4 Gene

2 Reactome pathways for KRBOX4 Gene

Interacting Proteins for KRBOX4 Gene

Gene Ontology (GO) - Biological Process for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

No data available for SIGNOR curated interactions for KRBOX4 Gene

Drugs & Compounds for KRBOX4 Gene

(2) Drugs for KRBOX4 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
estrogen Pharma 0

(3) Additional Compounds for KRBOX4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cycloheximide
Oligonucleotide
Steroid
genes like me logo Genes that share compounds with KRBOX4: view

Transcripts for KRBOX4 Gene

Unigene Clusters for KRBOX4 Gene

KRAB box domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBOX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBOX4 Gene

No ASD Table

Relevant External Links for KRBOX4 Gene

GeneLoc Exon Structure for
KRBOX4
ECgene alternative splicing isoforms for
KRBOX4

Expression for KRBOX4 Gene

mRNA expression in normal human tissues for KRBOX4 Gene

SOURCE GeneReport for Unigene cluster for KRBOX4 Gene Hs.632800

mRNA Expression by UniProt/SwissProt for KRBOX4 Gene

Q5JUW0-KRBX4_HUMAN
Tissue specificity: Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and kidney.
genes like me logo Genes that share expression patterns with KRBOX4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRBOX4 Gene

Orthologs for KRBOX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRBOX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF673 35
  • 98.8 (n)
  • 99.4 (a)
KRBOX4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KRBOX4 36
  • 17 (a)
OneToOne
Species with no ortholog for KRBOX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBOX4 Gene

ENSEMBL:
Gene Tree for KRBOX4 (if available)
TreeFam:
Gene Tree for KRBOX4 (if available)

Paralogs for KRBOX4 Gene

(250) SIMAP similar genes for KRBOX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBOX4: view

No data available for Paralogs for KRBOX4 Gene

Variants for KRBOX4 Gene

Sequence variations from dbSNP and Humsavar for KRBOX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs734040 -- 46,460,623(-) AATAA(C/G)GACAA intron-variant
rs734041 -- 46,460,626(-) AACAA(C/T)AACGA intron-variant
rs943013 -- 46,461,005(+) aaaga(C/T)acttt intron-variant
rs2031568 -- 46,453,680(+) AATGT(A/T)AACCA intron-variant
rs2031569 -- 46,470,452(+) atgat(A/G)cttta intron-variant

Variation tolerance for KRBOX4 Gene

Residual Variation Intolerance Score: 59.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRBOX4 Gene

HapMap Linkage Disequilibrium report
KRBOX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRBOX4 Gene

Disorders for KRBOX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRBOX4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diffuse mesangial sclerosis
  • diffuse isolated mesangial sclerosis
- elite association

Relevant External Links for KRBOX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRBOX4
genes like me logo Genes that share disorders with KRBOX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRBOX4 Gene

Publications for KRBOX4 Gene

  1. Model mechanisms of sulfhydryl oxidation by methyl- and benzeneseleninic acid, inhibitors of zinc-finger transcription factors. (PMID: 19864028) Bayse C.A. (J. Inorg. Biochem. 2010) 23 67
  2. A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts. (PMID: 20190190) Wilber A. … Nienhuis A.W. (Blood 2010) 23 67
  3. Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells. (PMID: 20388540) Mancini M. … Santucci M.A. (Cell. Signal. 2010) 23 67
  4. Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. (PMID: 20062079) Yamasaki N. … Honda H. (Oncogene 2010) 23 67
  5. Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. (PMID: 20484821) Grigorieva I.V. … Thakker R.V. (J. Clin. Invest. 2010) 23 67

Products for KRBOX4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRBOX4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRBOX4
    • Block miRNA regulation of KRBOX4 using miScript Target Protectors

    Sources for KRBOX4 Gene

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