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Aliases for KRBOX4 Gene

Aliases for KRBOX4 Gene

  • KRAB Box Domain Containing 4 2 3
  • ZNF673 3 4 6
  • KRAB Box Domain-Containing Protein 4 3 4
  • Zinc Finger Family Member 673 2 3
  • Zinc Finger Protein 673 2 3
  • Putative Zinc Finger Transcription Factor 3
  • KRAB Domain-Containing Protein 4 3
  • Hypothetical Protein FLJ20344 2
  • FLJ20344 6

External Ids for KRBOX4 Gene

Previous HGNC Symbols for KRBOX4 Gene

  • ZNF673

Previous GeneCards Identifiers for KRBOX4 Gene

  • GC0XP046307

Summaries for KRBOX4 Gene

Entrez Gene Summary for KRBOX4 Gene

  • This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for KRBOX4 Gene

KRBOX4 (KRAB Box Domain Containing 4) is a Protein Coding gene. Diseases associated with KRBOX4 include diffuse mesangial sclerosis and wilms tumor. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBOX4 Gene

Genomics for KRBOX4 Gene

Genomic Location for KRBOX4 Gene

46,446,857 bp from pter
46,497,422 bp from pter
50,566 bases
Plus strand

Genomic View for KRBOX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRBOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBOX4 Gene

No data available for Regulatory Elements for KRBOX4 Gene

Proteins for KRBOX4 Gene

  • Protein details for KRBOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KRAB domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K0Y8
    • B3KU22
    • Q96EA3
    • Q9NXB1

    Protein attributes for KRBOX4 Gene

    171 amino acids
    Molecular mass:
    20100 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRBOX4 Gene


neXtProt entry for KRBOX4 Gene

Proteomics data for KRBOX4 Gene at MOPED

Post-translational modifications for KRBOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRBOX4 Gene

No data available for DME Specific Peptides for KRBOX4 Gene

Domains for KRBOX4 Gene

Protein Domains for KRBOX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5JUW0
  • Contains 1 KRAB domain.
genes like me logo Genes that share domains with KRBOX4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KRBOX4 Gene

Function for KRBOX4 Gene

Gene Ontology (GO) - Molecular Function for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBOX4: view
genes like me logo Genes that share phenotypes with KRBOX4: view

miRNA for KRBOX4 Gene

miRTarBase miRNAs that target KRBOX4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRBOX4 Gene

Localization for KRBOX4 Gene

Gene Ontology (GO) - Cellular Components for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KRBOX4 Gene

Pathways for KRBOX4 Gene

SuperPathways for KRBOX4 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with KRBOX4: view

Pathways by source for KRBOX4 Gene

2 Reactome pathways for KRBOX4 Gene

Interacting Proteins for KRBOX4 Gene

Gene Ontology (GO) - Biological Process for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

Compounds for KRBOX4 Gene

(5) Novoseek inferred chemical compound relationships for KRBOX4 Gene

Compound -log(P) Hits PubMed IDs
zinc 64 30
cycloheximide 14.5 1
oligonucleotide 0 1
steroid 0 1
estrogen 0 4
genes like me logo Genes that share compounds with KRBOX4: view

Transcripts for KRBOX4 Gene

Unigene Clusters for KRBOX4 Gene

KRAB box domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRBOX4 Gene

No ASD Table

Relevant External Links for KRBOX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRBOX4 Gene

mRNA expression in normal human tissues for KRBOX4 Gene

SOURCE GeneReport for Unigene cluster for KRBOX4 Gene Hs.632800

mRNA Expression by UniProt/SwissProt for KRBOX4 Gene

Tissue specificity: Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and kidney.
genes like me logo Genes that share expressions with KRBOX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for KRBOX4 Gene

Orthologs for KRBOX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRBOX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRBOX4 36
  • 94 (a)
ZNF673 35
  • 98.8 (n)
  • 99.4 (a)
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
-- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia KRBOX4 36
  • 17 (a)
Species with no ortholog for KRBOX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBOX4 Gene

Gene Tree for KRBOX4 (if available)
Gene Tree for KRBOX4 (if available)

Paralogs for KRBOX4 Gene

Selected SIMAP similar genes for KRBOX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBOX4: view

No data available for Paralogs for KRBOX4 Gene

Variants for KRBOX4 Gene

Sequence variations from dbSNP and Humsavar for KRBOX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs734040 -- 46,460,623(-) AATAA(C/G)GACAA intron-variant
rs734041 -- 46,460,626(-) AACAA(C/T)AACGA intron-variant
rs2031568 -- 46,453,680(+) AATGT(A/T)AACCA intron-variant
rs2031569 -- 46,470,452(+) atgat(A/G)cttta intron-variant
rs2104470 -- 46,461,453(+) GAGAA(A/G)CCTGC intron-variant

Relevant External Links for KRBOX4 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRBOX4 Gene

Disorders for KRBOX4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KRBOX4 Gene including...

Search for KRBOX4 Gene in MalaCards »

(9) Novoseek inferred disease relationships for KRBOX4 Gene

Disease -log(P) Hits PubMed IDs
lymphoma large cell diffuse 61.6 3
wilms tumor 54.4 9
charcot-marie-tooth disease 21.1 2
tumors 18.1 7
cancer 12.3 3
genes like me logo Genes that share disorders with KRBOX4: view

No data available for UniProtKB/Swiss-Prot for KRBOX4 Gene

Publications for KRBOX4 Gene

  1. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KRBOX4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRBOX4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRBOX4
    • Block miRNA regulation of KRBOX4 using miScript Target Protectors

    Sources for KRBOX4 Gene

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