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KRBOX4 Gene

protein-coding   GIFtS: 43
GCID: GC0XP046307

KRAB Box Domain Containing 4

(Previous names: zinc finger protein 673, zinc finger family member 673)
(Previous symbol: ZNF673)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KRAB Box Domain Containing 41 2     Hypothetical Protein FLJ203441
ZNF6731 2 3 5     KRAB Domain-Containing Protein 42
Zinc Finger Family Member 6731 2     Putative Zinc Finger Transcription Factor2
Zinc Finger Protein 6731 2     FLJ203445
KRAB Box Domain-Containing Protein 42 3     

External Ids:    HGNC: 260071   Entrez Gene: 556342   Ensembl: ENSG000001471217   OMIM: 3005855   UniProtKB: Q5JUW03   

Export aliases for KRBOX4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRBOX4 Gene:
This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional
repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked
mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2011)

GeneCards Summary for KRBOX4 Gene:
KRBOX4 (KRAB box domain containing 4) is a protein-coding gene. Diseases associated with KRBOX4 include diffuse mesangial sclerosis, and transient neonatal diabetes mellitus. GO annotations related to this gene include nucleic acid binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KRBOX4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRBOX4 promoter sequence
   Search Chromatin IP Primers for KRBOX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRBOX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.3

KRBOX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRBOX4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP046307:  view genomic region     (about GC identifiers)

Start:
46,306,292 bp from pter      End:
46,356,857 bp from pter
Size:
50,566 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KRBX4_HUMAN, Q5JUW0 (See protein sequence)
Recommended Name: KRAB domain-containing protein 4  
Size: 171 amino acids; 20100 Da
Caution: Despite its name, it does not contain a canonical C2H2-type zinc-finger, seems to be a partial inverted
duplication of ZNF674
Secondary accessions: A8K0Y8 B3KU22 Q96EA3 Q9NXB1
Alternative splicing: 3 isoforms:  Q5JUW0-1   Q5JUW0-2   Q5JUW0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRBOX4: NX_Q5JUW0

Explore proteomics data for KRBOX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRBOX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123370.1  NP_001123371.1  NP_001123372.1  NP_060246.2  

    ENSEMBL proteins: 
     ENSP00000345797   ENSP00000298190   ENSP00000367152   ENSP00000418205   ENSP00000418146  
     ENSP00000418076   ENSP00000353113  
    Reactome Protein details: Q5JUW0

    KRBOX4 Human Recombinant Protein Products:

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    Novus Biologicals KRBOX4 Protein
    Novus Biologicals KRBOX4 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    KRBOX4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR026613 KRAB_dom_C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry Q5JUW0

    ProtoNet protein and cluster: Q5JUW0

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: KRBX4_HUMAN, Q5JUW0
    Similarity: Contains 1 KRAB domain


    KRBOX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
         
    KRBOX4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KRBOX4:
     Increased cell number in G1, a  Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRBOX4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRBOX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRBOX4

    miRNA
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    miRTarBase miRNAs that target KRBOX4:
    hsa-let-7e-5p (MIRT051568)

    Block miRNA regulation of human, mouse, rat KRBOX4 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidKRBOX4 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat KRBOX4

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRBOX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    KRBOX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KRBOX4 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KRBOX4
        Generic Transcription Pathway



    KRBOX4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRBOX4
    Interactions:

        Search GeneGlobe Interaction Network for KRBOX4

    1 Interacting protein for KRBOX4 (Q5JUW03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERBP1Q8NC513I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    KRBOX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRBOX4 (KRBX4)

    5 Novoseek inferred chemical compound relationships for KRBOX4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 64 33 16253273 (3), 16899226 (2), 17186549 (2), 15830130 (2) (see all 25)
    cycloheximide 14.5 1 1907289 (1)
    oligonucleotide 0 1 18059339 (1)
    steroid 0 1 15725073 (1)
    estrogen 0 5 15171706 (1), 16766568 (1), 18528430 (1), 9598871 (1)



    KRBOX4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRBOX4 gene (4 alternative transcripts): 
    NM_001129898.1  NM_001129899.1  NM_001129900.1  NM_017776.2  

    Unigene Cluster for KRBOX4:

    KRAB box domain containing 4
    Hs.632800  [show with all ESTs]
    Unigene Representative Sequence: AK097159
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344302(uc004dgm.4 uc004dgn.4) ENST00000298190 ENST00000377919
    ENST00000464900 ENST00000476762 ENST00000478600 ENST00000487081 ENST00000360017(uc004dgp.4 uc010nhl.3)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKRBOX4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KRBOX4
    Predesigned siRNA for gene silencing in human, mouse, rat KRBOX4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRBOX4
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KRBOX4
      QuantiFast Probe-based Assays in human, mouse, rat KRBOX4

    Additional mRNA sequence: 

    AK000351.1 AK096413.1 AK097159.1 AK289703.1 BC012569.1 

    10 DOTS entries:

    DT.408353  DT.92420903  DT.99933524  DT.205238  DT.100843106  DT.97801358  DT.100811837  DT.121280663 
    DT.121280710  DT.91752331 

    Selected AceView cDNA sequences (see all 29):

    AA635575 CR622119 BQ012976 AK096413 CR625694 AA635567 CA426530 CR602455 
    BQ014056 AA716653 AK097159 BX404511 BC012569 NM_017776 AA642386 BQ012454 
    N47058 AK000351 BX358973 BX358972 BX403763 BG951153 BM840265 AL547961 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRBOX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KRBOX4 Expression
    About this image

    KRBOX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRBOX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632800

    UniProtKB/Swiss-Prot: KRBX4_HUMAN, Q5JUW0
    Tissue specificity: Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and
    kidney

        Custom PCR Arrays for KRBOX4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRBOX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for KRBOX4 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    Uncharacterized protein
    67(a)
    55(a)
    many → 1
    many → 1
    X(40171982-40172842)
    X(40122399-40153968)


    ENSEMBL Gene Tree for KRBOX4 (if available)
    TreeFam Gene Tree for KRBOX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRBOX4 gene
    Selected SIMAP similar genes for KRBOX4 using alignment to 3 protein entries:     KRBX4_HUMAN (see all proteins) (see all similar genes):
    ZNF674    ZNF529    ZNF420    ZNF334    ZNF382    ZNF81
    ZNF559    ZNF350    FIK    ZNF20    ZNF429    ZNF627
    ZNF721    ZNF93    ZNF649    ZNF761    ZFP90    ZNF415

    KRBOX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRBOX4 (see all 457)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497594461,2
    --46223498(+) TTACAA/GATGCA 4 -- us2k10--------
    rs1458768781,2
    --46223524(+) GGGCAA/GTAATG 4 -- us2k10--------
    rs1842583411,2
    C--46223568(+) CACAAA/TTAAGG 4 -- us2k10--------
    rs1885538151,2
    --46223578(+) GAAAGG/TGGCTT 4 -- us2k10--------
    rs1812114311,2
    --46223579(+) AAAGGA/GGCTTC 4 -- us2k10--------
    rs1485819501,2
    C--46223780(+) GCAGCC/TATCTA 4 -- us2k10--------
    rs59523771,2
    C,F,H--46223817(+) AAAGCG/AGGGGA 4 -- us2k17Minor allele frequency- A:0.09NS EA 1086
    rs1862054191,2
    --46224039(+) AATCTC/TCATAT 4 -- us2k10--------
    rs1907762471,2
    --46224157(+) CGTGAC/TAGTGA 4 -- us2k10--------
    rs1477190031,2
    C--46224277(+) ATTCAC/TTGCTC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for KRBOX4 (46306292 - 46356857 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KRBOX4: --
    Locus Specific Mutation Databases (LSDB): KRBOX4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRBOX4
    DNA2.0 Custom Variant and Variant Library Synthesis for KRBOX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300585    OMIM disorders: --

    Selected diseases for KRBOX4 (see all 28):    
    About MalaCards
    diffuse mesangial sclerosis    transient neonatal diabetes mellitus    renal dysplasia    neonatal diabetes mellitus
    follicular lymphoma    wilms tumor    craniosynostosis    chronic myeloid leukemia
    hypoparathyroidism    tooth disease    tonsillitis    charcot-marie-tooth disease
    esophageal squamous cell carcinoma    diabetes mellitus    mental retardation    myeloid leukemia
    acute myeloid leukemia    renal cell carcinoma    b-cell lymphomas    hiv-1


    KRBOX4 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KRBOX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma large cell diffuse 61.6 3 8618933 (1), 8557040 (1), 7677752 (1)
    wilms tumor 54.4 9 9920756 (1), 9529364 (1), 9751632 (1), 18535006 (1) (see all 9)
    charcot-marie-tooth disease 21.1 2 11523566 (1), 11499640 (1)
    tumors 18.1 8 10525184 (1), 16950398 (1), 19188491 (1), 8773576 (1) (see all 7)
    cancer 12.3 3 15171706 (1), 19411256 (1), 7585125 (1)
    breast cancer 2.93 2 15171706 (1), 12473647 (1)
    heart defects congenital 0 1 16380715 (1)
    lymphoma non-hodgkins 0 1 11579468 (1)
    carcinoma 0 1 15581945 (1)


    Export disorders for KRBOX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRBOX4 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with KRBOX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1, 2, 3 Thiselton D.L.... Meindl A. (Genomics 2002)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. ZNF674: a new Kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation. (PubMed id 16385466)1 Lugtenberg D.... van Bokhoven H. (Am. J. Hum. Genet. 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Engineering zinc finger protein transcription factors: the therapeutic relevance of switching endogenous gene expression on or off at command. (PubMed id 16253273)9 Gommans W.M....Rots M.G. (J. Mol. Biol. 2005)
    9. The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. (PubMed id 18059339)9 Liu D....Zachary I. (Oncogene 2008)
    10. Regulation of endogenous gene expression using small molecule-controlled engineered zinc-finger protein transcription factors. (PubMed id 17637799)9 Dent C.L....Gregory P.D. (Gene Ther. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55634 HGNC: 26007 AceView: FLJ20344 Ensembl:ENSG00000147121 euGenes: HUgn55634
    ECgene: KRBOX4 H-InvDB: KRBOX4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KRBOX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRBOX4 gene:
    Search GeneIP for patents involving KRBOX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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