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Aliases for KRBOX1 Gene

Aliases for KRBOX1 Gene

  • KRAB Box Domain Containing 1 2 3 5

External Ids for KRBOX1 Gene

Previous GeneCards Identifiers for KRBOX1 Gene

  • GC00U931191
  • GC03P042852
  • GC03P042854
  • GC03P042810
  • GC03P042814
  • GC03P042816
  • GC03P042818
  • GC03P042820

Summaries for KRBOX1 Gene

GeneCards Summary for KRBOX1 Gene

KRBOX1 (KRAB Box Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000273291.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBOX1 Gene

Genomics for KRBOX1 Gene

Regulatory Elements for KRBOX1 Gene

Enhancers for KRBOX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G042759 1.6 Ensembl ENCODE dbSUPER 11.5 -47.9 -47861 3.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 CCDC13-AS1 KRBOX1 SEC22C POMGNT2 HIGD1A LINC02158
GH03G042880 1.6 FANTOM5 Ensembl ENCODE 10.7 +71.6 71557 1.3 PKNOX1 ATF1 AGO1 ARID4B DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 HIGD1A ENSG00000235288 ACKR2 ZNF662 CCDC13 LINC02158 KRBOX1 CYP8B1 POMGNT2 HNRNPA1P22
GH03G042700 1.5 Ensembl ENCODE dbSUPER 11.4 -107.3 -107272 2.5 PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF143 KLF13 KDM4B KRBOX1 SEC22C POMGNT2 HHATL HHATL-AS1 KLHL40
GH03G042778 1.3 Ensembl ENCODE 11.3 -30.3 -30297 1.8 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF302 FOS KLF7 HIGD1A CCDC13-AS1 ACKR2 KRBOX1 CCDC13 GC03P042799
GH03G042718 0.8 dbSUPER 11.4 -90.3 -90294 1.5 SOX13 CEBPG ZNF644 ZNF697 ZNF7 TEAD3 RARA THAP11 GATAD2A NFIA CCDC13-AS1 KRBOX1 SEC22C POMGNT2 HHATL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRBOX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRBOX1 Gene

Chromosome:
3
Start:
42,809,483 bp from pter
End:
42,942,792 bp from pter
Size:
133,310 bases
Orientation:
Plus strand

Genomic View for KRBOX1 Gene

Genes around KRBOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBOX1 Gene

Proteins for KRBOX1 Gene

  • Protein details for KRBOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JBD0-KRBX1_HUMAN
    Recommended name:
    KRAB domain-containing protein 1
    Protein Accession:
    C9JBD0
    Secondary Accessions:
    • B4DJE8

    Protein attributes for KRBOX1 Gene

    Size:
    128 amino acids
    Molecular mass:
    14906 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRBOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRBOX1 Gene

Post-translational modifications for KRBOX1 Gene

No Post-translational modifications

Other Protein References for KRBOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRBOX1 Gene

Domains & Families for KRBOX1 Gene

Protein Domains for KRBOX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBOX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRBOX1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRBOX1 Gene

Function for KRBOX1 Gene

Gene Ontology (GO) - Molecular Function for KRBOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBOX1: view

Phenotypes for KRBOX1 Gene

GenomeRNAi human phenotypes for KRBOX1:
genes like me logo Genes that share phenotypes with KRBOX1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRBOX1 Gene

Localization for KRBOX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRBOX1 gene
Compartment Confidence
extracellular 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KRBOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBOX1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBOX1 Gene

Pathways & Interactions for KRBOX1 Gene

SuperPathways for KRBOX1 Gene

No Data Available

Interacting Proteins for KRBOX1 Gene

Gene Ontology (GO) - Biological Process for KRBOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KRBOX1: view

No data available for Pathways by source and SIGNOR curated interactions for KRBOX1 Gene

Drugs & Compounds for KRBOX1 Gene

No Compound Related Data Available

Transcripts for KRBOX1 Gene

mRNA/cDNA for KRBOX1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBOX1 Gene

KRAB box domain containing 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBOX1 Gene

No ASD Table

Relevant External Links for KRBOX1 Gene

GeneLoc Exon Structure for
KRBOX1
ECgene alternative splicing isoforms for
KRBOX1

Expression for KRBOX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRBOX1 Gene

mRNA differential expression in normal tissues according to GTEx for KRBOX1 Gene

This gene is overexpressed in Testis (x24.2).

NURSA nuclear receptor signaling pathways regulating expression of KRBOX1 Gene:

KRBOX1

SOURCE GeneReport for Unigene cluster for KRBOX1 Gene:

Hs.720172

Evidence on tissue expression from TISSUES for KRBOX1 Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KRBOX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRBOX1 Gene

Orthologs for KRBOX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRBOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
KRBOX1 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZNF8 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
ZNF266 35
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 12 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 6 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
OneToMany
Species where no ortholog for KRBOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBOX1 Gene

ENSEMBL:
Gene Tree for KRBOX1 (if available)
TreeFam:
Gene Tree for KRBOX1 (if available)

Paralogs for KRBOX1 Gene

Paralogs for KRBOX1 Gene

Pseudogenes.org Pseudogenes for KRBOX1 Gene

genes like me logo Genes that share paralogs with KRBOX1: view

Variants for KRBOX1 Gene

Sequence variations from dbSNP and Humsavar for KRBOX1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000169940 -- 42,938,206(+) GGATT(A/C)TTTTA intron-variant, upstream-variant-2KB
rs1001051662 -- 42,935,144(+) TTACA(A/G)CCATC nc-transcript-variant, upstream-variant-2KB
rs1001201465 -- 42,939,363(+) GTTAT(A/G)TCTGT intron-variant
rs1001626683 -- 42,937,821(+) TGGAG(-/GGA)GGAGG intron-variant, upstream-variant-2KB
rs1001643133 -- 42,939,711(+) ACCAT(C/T)ACTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRBOX1 Gene

Variant ID Type Subtype PubMed ID
nsv590149 CNV gain 21841781

Variation tolerance for KRBOX1 Gene

Gene Damage Index Score: 11.34; 92.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRBOX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRBOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRBOX1 Gene

Disorders for KRBOX1 Gene

Relevant External Links for KRBOX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRBOX1

No disorders were found for KRBOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBOX1 Gene

Publications for KRBOX1 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for KRBOX1 Gene

Sources for KRBOX1 Gene

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