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Aliases for KRBA2 Gene

Aliases for KRBA2 Gene

  • KRAB-A Domain Containing 2 2 3 5
  • KRAB A Domain Containing 2 2

External Ids for KRBA2 Gene

Previous GeneCards Identifiers for KRBA2 Gene

  • GC17M008213
  • GC17M008271
  • GC17M008166

Summaries for KRBA2 Gene

GeneCards Summary for KRBA2 Gene

KRBA2 (KRAB-A Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBA2 Gene

Genomics for KRBA2 Gene

Regulatory Elements for KRBA2 Gene

Enhancers for KRBA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008375 1.1 ENCODE 19.1 +0.2 211 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 DEK ODF4 LOC105371523 KRBA2 MIR6883 RNF222 ENSG00000212206 SNORD10 PIR59981
GH17F008379 0.8 ENCODE 18 -6.0 -6040 6.2 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105371523 KRBA2 RPL26 NLGN2 SNORD10 ODF4 CNTROB CTC1 SNORA48 PFAS
GH17F008326 0.7 Ensembl ENCODE 11.5 +49.8 49810 1.8 RNF2 SAP130 L3MBTL2 UBTF ZNF48 ZBTB7A HBP1 GABPA POLR2A GABPB1 ODF4 KRBA2 SLC25A35 RANGRF PFAS CTC1 AURKB RNF222 SNORD118 TMEM107
GH17F008412 1.4 FANTOM5 Ensembl ENCODE 11.3 -36.3 -36271 1.6 KLF1 ATF1 TBL1XR1 JUN CEBPG HIC1 ZNF664 GLIS2 SCRT2 PRDM10 RPL26 KRBA2 SLC25A35 RANGRF PFAS NDEL1 PIK3R6 CNTROB PER1 BORCS6
GH17F008415 0.2 Ensembl 11.3 -38.6 -38590 0.2 ZNF781 RPL26 KRBA2 SLC25A35 RANGRF PFAS NDEL1 GC17P008467
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRBA2 on UCSC Golden Path with GeneCards custom track

Promoters for KRBA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340476 411 1401 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 DEK

Genomic Location for KRBA2 Gene

Chromosome:
17
Start:
8,368,637 bp from pter
End:
8,376,711 bp from pter
Size:
8,075 bases
Orientation:
Minus strand

Genomic View for KRBA2 Gene

Genes around KRBA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA2 Gene

Proteins for KRBA2 Gene

  • Protein details for KRBA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG9-KRBA2_HUMAN
    Recommended name:
    KRAB-A domain-containing protein 2
    Protein Accession:
    Q6ZNG9
    Secondary Accessions:
    • Q8IYY0

    Protein attributes for KRBA2 Gene

    Size:
    492 amino acids
    Molecular mass:
    56205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRBA2 Gene

Post-translational modifications for KRBA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBA2 Gene

Domains & Families for KRBA2 Gene

Protein Domains for KRBA2 Gene

Suggested Antigen Peptide Sequences for KRBA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG9

UniProtKB/Swiss-Prot:

KRBA2_HUMAN :
  • Contains 1 integrase catalytic domain.
Domain:
  • Contains 1 integrase catalytic domain.
  • Contains 1 KRAB domain.
genes like me logo Genes that share domains with KRBA2: view

No data available for Gene Families for KRBA2 Gene

Function for KRBA2 Gene

Gene Ontology (GO) - Molecular Function for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBA2: view
genes like me logo Genes that share phenotypes with KRBA2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBA2 Gene

Localization for KRBA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRBA2 Gene COMPARTMENTS Subcellular localization image for KRBA2 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA2 Gene

Pathways & Interactions for KRBA2 Gene

SuperPathways for KRBA2 Gene

No Data Available

Interacting Proteins for KRBA2 Gene

Gene Ontology (GO) - Biological Process for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Pathways by source and SIGNOR curated interactions for KRBA2 Gene

Transcripts for KRBA2 Gene

mRNA/cDNA for KRBA2 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBA2 Gene

KRAB-A domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA2 Gene

No ASD Table

Relevant External Links for KRBA2 Gene

GeneLoc Exon Structure for
KRBA2
ECgene alternative splicing isoforms for
KRBA2

Expression for KRBA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRBA2 Gene

Protein differential expression in normal tissues from HIPED for KRBA2 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRBA2 Gene



Protein tissue co-expression partners for KRBA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRBA2 Gene:

KRBA2

SOURCE GeneReport for Unigene cluster for KRBA2 Gene:

Hs.304604
genes like me logo Genes that share expression patterns with KRBA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRBA2 Gene

Orthologs for KRBA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRBA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRBA2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRBA2 34 35
  • 87.62 (n)
cow
(Bos Taurus)
Mammalia KRBA2 34
  • 86.11 (n)
mouse
(Mus musculus)
Mammalia 2410018M08Rik 35
  • 4 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 1 (a)
ManyToMany
-- 35
  • 1 (a)
ManyToMany
-- 35
  • 1 (a)
ManyToMany
-- 35
  • 1 (a)
ManyToMany
-- 35
  • 1 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii KRBA2 35
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 2 (a)
OneToOne
Species where no ortholog for KRBA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRBA2 Gene

ENSEMBL:
Gene Tree for KRBA2 (if available)
TreeFam:
Gene Tree for KRBA2 (if available)

Paralogs for KRBA2 Gene

(2) SIMAP similar genes for KRBA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBA2: view

Variants for KRBA2 Gene

Sequence variations from dbSNP and Humsavar for KRBA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1004151 -- 8,371,705(-) TAATA(A/C)ATGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111373953 -- 8,369,774(+) AAATG(A/G)ACTTG reference, missense
rs111396122 -- 8,375,589(+) AGAGT(A/G)CAGTG intron-variant
rs111643493 -- 8,370,370(+) ATGGA(A/G)AGCTG reference, synonymous-codon, utr-variant-5-prime
rs112398711 -- 8,371,332(+) CATAA(C/T)TGTCC intron-variant, reference, missense

Variation tolerance for KRBA2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRBA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRBA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRBA2 Gene

Disorders for KRBA2 Gene

Relevant External Links for KRBA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRBA2

No disorders were found for KRBA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBA2 Gene

Publications for KRBA2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for KRBA2 Gene

Sources for KRBA2 Gene

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