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Aliases for KRBA2 Gene

Aliases for KRBA2 Gene

  • KRAB-A Domain Containing 2 2 3
  • KRAB A Domain Containing 2 2

External Ids for KRBA2 Gene

Previous GeneCards Identifiers for KRBA2 Gene

  • GC17M008213
  • GC17M008271
  • GC17M008166

Summaries for KRBA2 Gene

GeneCards Summary for KRBA2 Gene

KRBA2 (KRAB-A Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM200B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBA2 Gene

Genomics for KRBA2 Gene

Regulatory Elements for KRBA2 Gene

Genomic Location for KRBA2 Gene

Chromosome:
17
Start:
8,368,637 bp from pter
End:
8,376,711 bp from pter
Size:
8,075 bases
Orientation:
Minus strand

Genomic View for KRBA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRBA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA2 Gene

Proteins for KRBA2 Gene

  • Protein details for KRBA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG9-KRBA2_HUMAN
    Recommended name:
    KRAB-A domain-containing protein 2
    Protein Accession:
    Q6ZNG9
    Secondary Accessions:
    • Q8IYY0

    Protein attributes for KRBA2 Gene

    Size:
    492 amino acids
    Molecular mass:
    56205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRBA2 Gene

Proteomics data for KRBA2 Gene at MOPED

Post-translational modifications for KRBA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRBA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRBA2 Gene

Domains & Families for KRBA2 Gene

Protein Domains for KRBA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG9

UniProtKB/Swiss-Prot:

KRBA2_HUMAN :
  • Contains 1 integrase catalytic domain.
Domain:
  • Contains 1 integrase catalytic domain.
  • Contains 1 KRAB domain.
genes like me logo Genes that share domains with KRBA2: view

No data available for Gene Families for KRBA2 Gene

Function for KRBA2 Gene

Gene Ontology (GO) - Molecular Function for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IBA --
genes like me logo Genes that share ontologies with KRBA2: view

Phenotypes for KRBA2 Gene

genes like me logo Genes that share phenotypes with KRBA2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBA2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBA2 Gene

Localization for KRBA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRBA2 Gene COMPARTMENTS Subcellular localization image for KRBA2 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA2 Gene

Pathways & Interactions for KRBA2 Gene

SuperPathways for KRBA2 Gene

No Data Available

Interacting Proteins for KRBA2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328017%0d%0a9606.ENSP00000365637%0d%0a9606.ENSP00000378451%0d%0a9606.ENSP00000226319%0d%0a9606.ENSP00000218343%0d%0a
Selected Interacting proteins: ENSP00000328017 for KRBA2 Gene via STRING

Gene Ontology (GO) - Biological Process for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0015074 DNA integration IEA --
GO:0032197 transposition, RNA-mediated IBA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Pathways by source and SIGNOR curated interactions for KRBA2 Gene

Drugs & Compounds for KRBA2 Gene

No Compound Related Data Available

Transcripts for KRBA2 Gene

mRNA/cDNA for KRBA2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBA2 Gene

KRAB-A domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA2 Gene

No ASD Table

Relevant External Links for KRBA2 Gene

GeneLoc Exon Structure for
KRBA2
ECgene alternative splicing isoforms for
KRBA2

Expression for KRBA2 Gene

mRNA expression in normal human tissues for KRBA2 Gene

Protein differential expression in normal tissues from HIPED for KRBA2 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRBA2 Gene



SOURCE GeneReport for Unigene cluster for KRBA2 Gene Hs.304604

genes like me logo Genes that share expression patterns with KRBA2: view

Protein tissue co-expression partners for KRBA2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRBA2 Gene

Orthologs for KRBA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRBA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRBA2 35
  • 86.11 (n)
  • 83.75 (a)
dog
(Canis familiaris)
Mammalia KRBA2 35
  • 87.62 (n)
  • 85.43 (a)
KRBA2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2410018M08Rik 36
  • 4 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRBA2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 1 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii KRBA2 36
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 2 (a)
OneToOne
Species with no ortholog for KRBA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRBA2 Gene

ENSEMBL:
Gene Tree for KRBA2 (if available)
TreeFam:
Gene Tree for KRBA2 (if available)

Paralogs for KRBA2 Gene

Paralogs for KRBA2 Gene

(2) SIMAP similar genes for KRBA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBA2: view

Variants for KRBA2 Gene

Sequence variations from dbSNP and Humsavar for KRBA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_051087 -

Structural Variations from Database of Genomic Variants (DGV) for KRBA2 Gene

Variant ID Type Subtype PubMed ID
dgv3057n71 CNV Loss 21882294

Variation tolerance for KRBA2 Gene

Residual Variation Intolerance Score: 87.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRBA2 Gene

HapMap Linkage Disequilibrium report
KRBA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRBA2 Gene

Disorders for KRBA2 Gene

Relevant External Links for KRBA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRBA2
genes like me logo Genes that share disorders with KRBA2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBA2 Gene

Publications for KRBA2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for KRBA2 Gene

Sources for KRBA2 Gene

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