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Aliases for KRBA1 Gene

Aliases for KRBA1 Gene

  • KRAB-A Domain Containing 1 2 3 5
  • KRAB A Domain Containing 1 2
  • KIAA1862 4

External Ids for KRBA1 Gene

Previous GeneCards Identifiers for KRBA1 Gene

  • GC07P149043
  • GC07P149411
  • GC07P143488

Summaries for KRBA1 Gene

GeneCards Summary for KRBA1 Gene

KRBA1 (KRAB-A Domain Containing 1) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBA1 Gene

Genomics for KRBA1 Gene

Regulatory Elements for KRBA1 Gene

Enhancers for KRBA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F149741 0.8 Ensembl ENCODE 11.5 +27.4 27398 1.2 ZFP64 ARID4B SIN3A ZBTB40 ZNF2 RAD21 SCRT2 ZNF143 CREM ZNF362 SSPO ZNF467 KRBA1 ZNF862 GC07M149707 GC07M149505
GH07F149714 0.5 ENCODE 8 +1.1 1072 3.4 HDGF ATF1 MLX ARID4B GLI4 ZNF2 ETS1 ELK1 ZNF143 ZNF202 ZNF212 ENSG00000271664 ZNF783 LOC155060 ZNF398 ZNF282 ZNF777 RARRES2 ZNF767P KRBA1
GH07F149720 0.2 ENCODE 7.1 +6.4 6364 0.4 IKZF1 TBX21 ZIC2 SSPO ZNF862 KRBA1 GC07M149707 GC07M149505
GH07F149662 1.1 Ensembl ENCODE 6.6 -51.8 -51787 1.0 ELF3 CTCF KLF1 ZIC2 ZNF2 RAD21 ZNF143 SMC3 KLF7 CREM SSPO ZNF862 KRBA1 GC07P149665 GC07P149650 GC07P149652 GC07P149653 GC07P149654 GC07P149655
GH07F149718 0.9 Ensembl ENCODE 5.3 +5.0 4996 2.3 HDGF PKNOX1 ARNT CREB3L1 ZNF2 CBX5 ZNF302 FOS SP3 JUNB SSPO ZNF862 KRBA1 GC07M149707 GC07M149505
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRBA1 on UCSC Golden Path with GeneCards custom track

Promoters for KRBA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000636076 19 1601 ATF1 MLX ARID4B GLI4 ZNF2 ETS1 ELK1 ZNF143 ZNF202 SP3

Genomic Location for KRBA1 Gene

Chromosome:
7
Start:
149,714,781 bp from pter
End:
149,734,575 bp from pter
Size:
19,795 bases
Orientation:
Plus strand

Genomic View for KRBA1 Gene

Genes around KRBA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA1 Gene

Proteins for KRBA1 Gene

  • Protein details for KRBA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PL33-KRBA1_HUMAN
    Recommended name:
    Protein KRBA1
    Protein Accession:
    A5PL33
    Secondary Accessions:
    • A7E2F5
    • E7ENE9
    • Q8N4X0
    • Q96JG5

    Protein attributes for KRBA1 Gene

    Size:
    1030 amino acids
    Molecular mass:
    107498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRBA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRBA1 Gene

Post-translational modifications for KRBA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBA1 Gene

Domains & Families for KRBA1 Gene

Protein Domains for KRBA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRBA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRBA1 Gene

Function for KRBA1 Gene

Gene Ontology (GO) - Molecular Function for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBA1: view
genes like me logo Genes that share phenotypes with KRBA1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBA1 Gene

Localization for KRBA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRBA1 Gene COMPARTMENTS Subcellular localization image for KRBA1 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA1 Gene

Pathways & Interactions for KRBA1 Gene

SuperPathways for KRBA1 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with KRBA1: view

Pathways by source for KRBA1 Gene

2 Reactome pathways for KRBA1 Gene

Interacting Proteins for KRBA1 Gene

Selected Interacting proteins: A5PL33-KRBA1_HUMAN for KRBA1 Gene via IID

Gene Ontology (GO) - Biological Process for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRBA1: view

No data available for SIGNOR curated interactions for KRBA1 Gene

Transcripts for KRBA1 Gene

mRNA/cDNA for KRBA1 Gene

(10) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBA1 Gene

KRAB-A domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KRBA1 Gene

GeneLoc Exon Structure for
KRBA1
ECgene alternative splicing isoforms for
KRBA1

Expression for KRBA1 Gene

mRNA expression in normal human tissues for KRBA1 Gene

mRNA differential expression in normal tissues according to GTEx for KRBA1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for KRBA1 Gene

This gene is overexpressed in Prostate (53.2) and Stomach (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRBA1 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRBA1 Gene:

KRBA1

SOURCE GeneReport for Unigene cluster for KRBA1 Gene:

Hs.299560

mRNA Expression by UniProt/SwissProt for KRBA1 Gene:

A5PL33-KRBA1_HUMAN
Tissue specificity: Expressed in brain (cerebellum).
genes like me logo Genes that share expression patterns with KRBA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for KRBA1 Gene

Orthologs for KRBA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRBA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRBA1 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia KRBA1 34 35
  • 76.68 (n)
cow
(Bos Taurus)
Mammalia KRBA1 34 35
  • 74.52 (n)
mouse
(Mus musculus)
Mammalia Krba1 34 16 35
  • 71.74 (n)
rat
(Rattus norvegicus)
Mammalia Krba1 34
  • 71.69 (n)
oppossum
(Monodelphis domestica)
Mammalia KRBA1 35
  • 33 (a)
OneToOne
Species where no ortholog for KRBA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBA1 Gene

ENSEMBL:
Gene Tree for KRBA1 (if available)
TreeFam:
Gene Tree for KRBA1 (if available)

Paralogs for KRBA1 Gene

No data available for Paralogs for KRBA1 Gene

Variants for KRBA1 Gene

Sequence variations from dbSNP and Humsavar for KRBA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10227504 -- 149,716,467(+) TGAGT(G/T)TTGTA intron-variant
rs10231875 -- 149,720,139(+) TATCT(A/G)TCAGA intron-variant
rs10237553 -- 149,716,371(+) CATTG(A/G)TTGGG intron-variant
rs10240931 -- 149,722,630(+) GCTCC(C/G)CCGCC intron-variant
rs10256826 -- 149,726,159(+) TGCCC(A/G)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRBA1 Gene

Variant ID Type Subtype PubMed ID
dgv1335e214 CNV loss 21293372
esv3576480 CNV gain 25503493
nsv1021849 CNV gain 25217958
nsv469576 CNV loss 16826518
nsv608979 CNV loss 21841781
nsv831184 CNV gain 17160897

Variation tolerance for KRBA1 Gene

Gene Damage Index Score: 5.61; 72.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRBA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRBA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRBA1 Gene

Disorders for KRBA1 Gene

Relevant External Links for KRBA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRBA1

No disorders were found for KRBA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBA1 Gene

Publications for KRBA1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PMID: 20368287) Pilot-Storck F. … Goillot E. (Mol. Cell Proteomics 2010) 3 64

Products for KRBA1 Gene

Sources for KRBA1 Gene

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