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Aliases for KRBA1 Gene

Aliases for KRBA1 Gene

  • KRAB-A Domain Containing 1 2 3
  • KRAB A Domain Containing 1 2
  • KIAA1862 4

External Ids for KRBA1 Gene

Previous GeneCards Identifiers for KRBA1 Gene

  • GC07P149043
  • GC07P149411
  • GC07P143488

Summaries for KRBA1 Gene

GeneCards Summary for KRBA1 Gene

KRBA1 (KRAB-A Domain Containing 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBA1 Gene

Genomics for KRBA1 Gene

Regulatory Elements for KRBA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRBA1 Gene

Start:
149,714,781 bp from pter
End:
149,734,575 bp from pter
Size:
19,795 bases
Orientation:
Plus strand

Genomic View for KRBA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRBA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA1 Gene

Proteins for KRBA1 Gene

  • Protein details for KRBA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PL33-KRBA1_HUMAN
    Recommended name:
    Protein KRBA1
    Protein Accession:
    A5PL33
    Secondary Accessions:
    • A7E2F5
    • E7ENE9
    • Q8N4X0
    • Q96JG5

    Protein attributes for KRBA1 Gene

    Size:
    1030 amino acids
    Molecular mass:
    107498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRBA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRBA1 Gene

Proteomics data for KRBA1 Gene at MOPED

Post-translational modifications for KRBA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRBA1 Gene

No data available for DME Specific Peptides for KRBA1 Gene

Domains for KRBA1 Gene

Protein Domains for KRBA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRBA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRBA1 Gene

Function for KRBA1 Gene

Gene Ontology (GO) - Molecular Function for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
genes like me logo Genes that share ontologies with KRBA1: view

Animal Model Products

CRISPR Products

miRNA for KRBA1 Gene

miRTarBase miRNAs that target KRBA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBA1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRBA1 Gene

Localization for KRBA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRBA1 Gene COMPARTMENTS Subcellular localization image for KRBA1 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with KRBA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA1 Gene

Pathways for KRBA1 Gene

SuperPathways for KRBA1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with KRBA1: view

Pathways by source for KRBA1 Gene

2 Reactome pathways for KRBA1 Gene

Interacting Proteins for KRBA1 Gene

Selected Interacting proteins: A5PL33-KRBA1_HUMAN for KRBA1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for KRBA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRBA1: view

Transcripts for KRBA1 Gene

mRNA/cDNA for KRBA1 Gene

(10) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBA1 Gene

KRAB-A domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRBA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRBA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KRBA1 Gene

GeneLoc Exon Structure for
KRBA1
ECgene alternative splicing isoforms for
KRBA1

Expression for KRBA1 Gene

mRNA expression in normal human tissues for KRBA1 Gene

mRNA differential expression in normal tissues according to GTEx for KRBA1 Gene

This gene is overexpressed in Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRBA1 Gene

SOURCE GeneReport for Unigene cluster for KRBA1 Gene Hs.299560

mRNA Expression by UniProt/SwissProt for KRBA1 Gene

A5PL33-KRBA1_HUMAN
Tissue specificity: Expressed in brain (cerebellum).
genes like me logo Genes that share expressions with KRBA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRBA1 Gene

Orthologs for KRBA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRBA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRBA1 35
  • 98.9 (n)
  • 98.35 (a)
KRBA1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRBA1 35
  • 74.52 (n)
  • 62.48 (a)
KRBA1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRBA1 35
  • 76.68 (n)
  • 66.94 (a)
KRBA1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krba1 35
  • 71.74 (n)
  • 59.74 (a)
Krba1 16
Krba1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRBA1 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krba1 35
  • 71.69 (n)
  • 59.7 (a)
Species with no ortholog for KRBA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBA1 Gene

ENSEMBL:
Gene Tree for KRBA1 (if available)
TreeFam:
Gene Tree for KRBA1 (if available)

Paralogs for KRBA1 Gene

No data available for Paralogs for KRBA1 Gene

Variants for KRBA1 Gene

Sequence variations from dbSNP and Humsavar for KRBA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs709065 - 149,730,319(+) CCTGA(G/T)CTCTG missense, reference
rs740135 -- 149,724,057(-) TCCCA(A/C)ACAGC intron-variant
rs740136 -- 149,724,119(-) CAGAA(C/T)GTCCA intron-variant
rs740137 -- 149,734,630(-) ACAAC(A/C)AGCCC intron-variant
rs740138 -- 149,734,898(-) TACAG(C/G)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRBA1 Gene

Variant ID Type Subtype PubMed ID
nsv469576 CNV Complex 16826518
nsv831184 CNV Gain 17160897

Relevant External Links for KRBA1 Gene

HapMap Linkage Disequilibrium report
KRBA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRBA1 Gene

Disorders for KRBA1 Gene

No disorders were found for KRBA1 Gene.

No data available for UniProtKB/Swiss-Prot for KRBA1 Gene

Publications for KRBA1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PMID: 20368287) Pilot-Storck F. … Goillot E. (Mol. Cell Proteomics 2010) 3
  4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for KRBA1 Gene

Sources for KRBA1 Gene

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