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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRAS Gene

protein-coding GIFtS: 69
GCID: GC12M025358

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

(Previous name: v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog...)
(Previous symbol: KRAS2)

Explore 169 diseases affiliated with
KRAS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog¹ ²		K-RAS4B²
KRAS2¹ ² ³ ⁵		KI-RAS²
RASK2² ³ ⁵		NS3²
KRAS1¹ ²		C-Kirsten-Ras Protein²
V-Ki-Ras2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog¹ ²		Cellular C-Ki-Ras2 Proto-Oncogene²
C-Ki-Ras¹		GTPase KRas²
K-Ras 2² ³		K-Ras P21 Protein²
NS² ⁵		Oncogene KRAS2²
C-K-RAS²		PR310 C-K-Ras Oncogene²
K-RAS2A²		Transforming Protein P21²
K-RAS2B²		Ki-Ras³
K-RAS4A²		C-K-Ras¹

External Ids:	HGNC: 6407¹	Entrez Gene: 3845²	Ensembl: ENSG00000133703⁷	OMIM: 190070⁵	UniProtKB: P01116³

Export aliases for KRAS gene to outside databases

Previous GC identifers: GC12M025250 GC12M025128

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRAS:

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the

small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming

protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal

carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that

differ in the C-terminal region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RASK_HUMAN, P01116

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for KRAS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRAS gene promoter:
TBP ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KRAS promoter sequence

Search SABiosciences Chromatin IP Primers for KRAS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRAS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.1

KRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRAS gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M025358: view genomic region (about GC identifiers)

Start:	25,357,723 bp from pter	End:	25,403,870 bp from pter
Size:	46,148 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RASK_HUMAN, P01116 (See protein sequence)

Recommended Name: GTPase KRas precursor

Size: 189 amino acids; 21656 Da

Subunit: Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity)

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side

6/13 PDB 3D structures from and Proteopedia for KRAS (see all 13):

1D8D (3D)

1D8E (3D)

1KZO (3D)

1KZP (3D)

3GFT (3D)

4DSN (3D)

Secondary accessions: A8K8Z5 B0LPF9 P01118 Q96D10

Alternative splicing: 2 isoforms: P01116-1 P01116-2, P01118-1 (Variant in position: 152:V->G (in NS3). Variant in position: 153:D->V (in CFC syndrome and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein). Variant in position: 156:F->I (in NS3/CFC syndrome). Variant in position: 156:F->L (found in a patient with Costello syndrome, exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors))

Explore the universe of human proteins at neXtProt for KRAS: NX_P01116

Post-translational modifications:

Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01116

KRAS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004976.2 NP_203524.1

ENSEMBL proteins:

ENSP00000308495 ENSP00000452512 ENSP00000256078 ENSP00000451856

Reactome Protein details: P01116
Human Recombinant Protein Products for KRAS:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): KRAS OriGene Protein Over-expression Lysate (see all 2): KRAS OriGene Custom Protein Services for KRAS
	GenScript Custom Purified and Recombinant Proteins Services for KRAS
	Novus Biologicals KRAS Proteins Novus Biologicals KRAS Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for KRAS
	Uscn Proteins for KRAS

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0045121	membrane raft	IEA	--

KRAS for ontologies About GeneDecksing

KRAS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KRAS
	R&D Systems Antibodies for KRAS (Ras)
	Cell Signaling Technology (CST) Antibodies for KRAS
	OriGene Antibodies (see all 11): KRAS OriGene Custom Antibody Services for KRAS
	GenScript Custom Superior Antibodies Services for KRAS
	Novus Biologicals KRAS Antibodies
	Abcam antibodies for KRAS
	Uscn Antibodies for KRAS
	Search ThermoFisher Antibodies for KRAS

Assay Products for KRAS:

	EMD Millipore Kits and Assays for the Analysis of KRAS
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KRAS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KRAS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRAS for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P01116

ProtoNet protein and cluster: P01116

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RASK_HUMAN, P01116

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RASK_HUMAN, P01116

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a

guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	IEA	--
GO:0019002	GMP binding	IEA	--
GO:0019003	GDP binding	IEA	--

KRAS for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for KRAS:

Decreased TP53 protein express

Decreased viability

Synthetic lethal with Ras

15/23 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Kras) (see all 23):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle

KRAS for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for KRAS: Kras^tm1Epa Kras^tm1Mok Kras^tm1Tyj

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KRAS

miRNA Products:		miRTarBase miRNAs that target KRAS: hsa-mir-181c (MIRT003210), hsa-let-7a (MIRT001855), hsa-mir-18a (MIRT000230), hsa-mir-143 (MIRT000312), hsa-let-7g (MIRT000399), hsa-mir-96 (MIRT005553), hsa-mir-155 (MIRT005100)

		OriGene 3'-UTR Clone (see all 2): KRAS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRAS
		8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate KRAS (see all 122):
		hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-300 hsa-miR-15a hsa-miR-134 hsa-miR-605 hsa-miR-30d hsa-miR-3653

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRAS (see all 7) OriGene shRNA RFP: KRAS OriGene siRNA: KRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRAS
		Sirion Biotech Custom design and validation of potent shRNA sequences against KRAS

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KRAS
			Sirion Biotech Customized adenovirus for overexpression of KRAS Sirion Biotech Customized adenovirus for potent knockdown of KRAS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRAS (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRAS (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for KRAS
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRAS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KRAS
		Search LifeMap BioReagents cell lines for KRAS
		Sirion Biotech Customized stable knockdown cell line services for KRAS Sirion Biotech Customized inducible knockdown cell line services for KRAS Sirion Biotech Customized stable overexpressing cell line services for KRAS Sirion Biotech Customized inducible overexpressing cell line services for KRAS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRAS

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/67 super-pathways (see all 67) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SHC-mediated signalling

8/13 pathways (see all 13)
SHC-mediated signalling	1.00	MEK activation	0.47
SHC-related events	0.88	RAF phosphorylates MEK	0.47
SHC-related events triggered by IGF1R	0.83	RAF activation	0.33
SHC1 events in EGFR signaling	0.76	EGFR Transactivation by Gastrin	0.26

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

IL-9 Signaling Pathways

IL-9 Signaling Pathways	1.00	IL-2 Signaling Pathways	0.88
IL-21 Signaling Pathways	0.90	IL-15 Signaling Pathways	0.86
IL-7 Signaling Pathways	0.90	IL-4 Signaling Pathways	0.80
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Adipocytokines & Insulin Signaling	0.33

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	Signaling by Insulin receptor	0.74
IRS-related events triggered by IGF1R	0.93

Glioma

Glioma	1.00	Prostate cancer	0.39
Non-small cell lung cancer	0.53	Signaling Pathways in Glioblastoma	0.36
Melanoma	0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for KRAS

	G-protein signaling K-RAS regulation pathway
	Development EGFR signaling via small GTPases
	Development EPO-induced MAPK pathway
	G-protein signaling Ras family GTPases in kinase cascades (scheme)

5/9 R&D Systems Pathways for KRAS (see all 9)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	Adipocytokines & Insulin Signaling
	IL-7 Signaling Pathways

1 Cell Signaling Technology (CST) Pathway for KRAS

MAP Kinase Signaling

5 Tocris Bioscience Pathways for KRAS

	Insulin Pathway
	Apoptosis Pathway
	TGF-beta Pathway
	NF-kappaB Pathway
	VEGF Pathway

4 GeneGo (Thomson Reuters) Pathways for KRAS

	Development EPO-induced MAPK pathway
	G-protein signaling Ras family GTPases in kinase cascades (scheme)
	Development EGFR signaling via small GTPases
	G-protein signaling K-RAS regulation pathway

5/14 BioSystems Pathways for KRAS (see all 14)

	Oncostatin M Signaling Pathway
	G Protein Signaling Pathways
	Signaling Pathways in Glioblastoma
	EGFR1 Signaling Pathway
	ErbB signaling pathway

5/65 Reactome Pathways for KRAS (see all 65)

	SHC-related events
	EGFR Transactivation by Gastrin
	p38MAPK events
	SHC-mediated signalling
	IRS-mediated signalling

5 PharmGKB Pathways for KRAS

	Bisphosphonate Pathway, Pharmacodynamics
	EGFR Inhibitor Pathway, Pharmacodynamics
	Sorafenib Pharmacodynamics
	VEGF Signaling Pathway
	Vemurafenib Pathway, Pharmacodynamics

5/36 Kegg Pathways (Kegg details for KRAS) (see all 36):

	MAPK signaling pathway
	ErbB signaling pathway
	Chemokine signaling pathway
	Dorso-ventral axis formation
	Axon guidance

KRAS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KRAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/80 Interacting proteins for KRAS (P01116^{1, 2, 3} ENSP00000256078⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 80)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCT7	Q99832²^,³, ENSP00000258091⁴	MINT-8259252 I2D: score=2 STRING: ENSP00000258091
EEF1A1	P68104²^,³, ENSP00000330054⁴	MINT-8259263 I2D: score=2 STRING: ENSP00000330054
IGSF21	Q96ID5²^,³, ENSP00000251296⁴	MINT-8259274 I2D: score=2 STRING: ENSP00000251296
PDE4DIP	Q5VU43²^,³	MINT-8259285 I2D: score=2
DEAF1	O75398²^,³	MINT-8258478 I2D: score=1

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0001934	positive regulation of protein phosphorylation	IMP	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--

KRAS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KRAS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRAS

1 HMDB Compound for KRAS About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 DrugBank Compounds for KRAS About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
FARNESYL	--	--	target	--	10592235
FARNESYL DIPHOSPHATE	--	--	target	--	10592235
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID	--	--	target	--	10592235

10/37 Novoseek chemical compound relationships for KRAS gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
panitumumab	92.6	77	20481659 (4), 20044619 (3), 20130433 (3), 19806185 (3) (see all 42)
cetuximab	91.6	159	20010090 (5), 16618717 (4), 19398573 (4), 18577988 (4) (see all 72)
erlotinib	84.3	23	15696205 (3), 18626007 (3), 16043828 (2), 19447865 (2) (see all 13)
gefitinib	81.3	28	15696205 (3), 18334834 (3), 18418018 (3), 17409929 (2) (see all 16)
crcs	80.3	21	19474002 (4), 19147861 (3), 19679400 (2), 19678923 (1) (see all 12)
irinotecan	65.3	18	19398573 (3), 19164213 (3), 19179548 (2), 19546597 (1) (see all 9)
oxaliplatin	63.1	5	19581179 (1), 20146801 (1), 19884549 (1), 20397915 (1)
tyrosine	59.9	31	18776048 (3), 19855375 (2), 15753357 (1), 20080496 (1) (see all 28)
o6-methylguanine	56.2	5	19164452 (1), 17867575 (1), 18300810 (1), 16118624 (1) (see all 5)
pd-184352	54.7	1	16957420 (1)

2 PharmGKB related drug/compound annotations for KRAS gene About this table

Drug/compound	PharmGKB Annotation
cetuximab	DL
panitumumab	DL

Search CenterWatch for drugs/clinical trials and news about KRAS / RASK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRAS gene (2 alternative transcripts):

NM_004985.3 NM_033360.2

Unigene Cluster for KRAS:

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Hs.505033 [show with all ESTs]

Unigene Representative Sequence: NM_033360

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311936(uc001rgp.1 uc001rgq.1) ENST00000557334 ENST00000256078

ENST00000556131(uc001rgr.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KRAS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRAS
		8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate KRAS (see all 122):
		hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-300 hsa-miR-15a hsa-miR-134 hsa-miR-605 hsa-miR-30d hsa-miR-3653

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRAS (see all 7) OriGene shRNA RFP: KRAS OriGene siRNA: KRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRAS
		Sirion Biotech Custom design and validation of potent shRNA sequences against KRAS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRAS (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRAS (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for KRAS
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRAS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KRAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRAS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRAS

Additional cDNA sequence:

AF493917.1 AK292510.1 BC010502.1 BC013572.2 BC029545.1 BT007153.1 M17087.1 M35504.1

M35505.1

17 DOTS entries:

DT.92460446 DT.99948002 DT.92460454 DT.95114183 DT.95114192 DT.100696548 DT.92008862 DT.121177012

DT.100811094 DT.100705577 DT.100696549 DT.100755557 DT.100810349 DT.95114240 DT.95205786 DT.95249640

DT.100701816

24/280 AceView cDNA sequences (see all 280):

BG261289 CR625034 BE464958 W21091 NM_033360 C01015 BF436494 AL553212

AA808271 AW167917 AI015987 AI281159 AA281094 AA564243 NM_004985 BU189436

AW160515 AI889481 BQ423435 AW173466 AA721296 AA287927 AA356548 AI500024

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRAS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTGTACTA

About this image

KRAS expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver

Liver

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KRAS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRAS

SOURCE GeneReport for Unigene cluster: Hs.505033

SABiosciences Expression via Pathway-Focused PCR Arrays including KRAS (see all 13):

mTOR Signaling in human mouse rat

Oncogenes & Tumor Suppressor Genes in human mouse rat

Lung Cancer in human mouse rat

Insulin Signaling Pathway in human mouse rat

VEGF Signaling in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRAS Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRAS

In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRAS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for KRAS gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KRAS¹	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	90.43(n) 98.94(a)		418207 XM_416436.3 XP_416436.1
lizard (Anolis carolinensis)	Reptilia	KRAS⁶	--	94(a)	1 ↔ 1	GL344156.1(55258-86337)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24980²	X.laevis mRNA for proto-oncogene K-Ras2A	81.16(n)		Y12715.1
zebrafish (Danio rerio)	Actinopterygii	kras¹	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	79.43(n) 96.28(a)		445289 NM_001003744.1 NP_001003744.1
fruit fly (Drosophila melanogaster)	Insecta	Ras85D¹	Ras oncogene at 85D	67.73(n) 79.79(a)		41140 NM_057351.4 NP_476699.1
worm (Caenorhabditis elegans)	Secernentea	let-60¹	Protein LET-60	67.57(n) 79.35(a)		178104 NM_069812.2 NP_502213.3
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RAS1¹	Ras1p	60.91(n) 64.2(a)		854268 NP_014744.1

ENSEMBL Gene Tree for KRAS (if available)
TreeFam Gene Tree for KRAS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRAS gene

REM1² RALA² RIT2² RIT1² RRAS² ERAS² RALB² NRAS²

RRAD² REM2² GEM² RRAS2² HRAS² MRAS²

18/89 SIMAP similar genes for KRAS using alignment to 30 protein entries: RASK_HUMAN (see all proteins) (see all similar genes):

N-ras K-RAS c-bas/has HRAS H-RAS K-ras

NRAS RAP1B RALA RAP2A RIT2 RRAS2

RALB RIT1 DKFZp547A0616 RERG RAP1A RHEB

KRAS for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KRAS
PGOHUM00000250209

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894360^1,2	C	pathogenic	25133552(-)	`TGTTGA/TTGATG`	3	D V	mis¹ ut3¹		0	--	--	--	--
rs104894367^1,2	C	pathogenic	25133555(-)	`GGGTGG/TTGATG`	3	G V	mis¹ ut3¹		0	--	--	--	--
rs104894359^1,2	C	pathogenic	25150959(-)	`CAGCAA/C/GGTCAA`	6	S R G	mis¹		0	--	--	--	--
rs104894364^1,2	C	pathogenic	25150964(-)	`CGACAC/TAGCAG`	4	T I	mis¹		0	--	--	--	--
rs104894366^1,2	C	pathogenic	25168843(-)	`TGATCC/GAACAA`	4	P R	mis¹		0	--	--	--	--
rs104894365^1,2	C	pathogenic	25168904(-)	`GTGGCG/ATAGGC`	4	/I /V	mis¹		1		NA	4522
rs104894361^1,2	C	pathogenic	25168929(-)	`TATAAA/TCTTGT`	4	K N	mis¹		0	--	--	--	--
rs17851045^1,2	C	other	25150954(-)	`GGTCAA/C/TGAGGA`	6	Q H	mis¹ ese³		2		NA	4
rs121913240^1,2	C	other	25150955(-)	`AGGTCA/C/G/T AGAGG`	8	Q P R L	mis¹		0	--	--	--	--
rs121913238^1,2	C	other	25150956(-)	`CAGGTA/C/GAAGAG`	6	K Q E	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KRAS (25357723 - 25403870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRAS: --
Human Gene Mutation Database (HGMD): KRAS

5/29 SABiosciences Cancer Mutation PCR Assays for KRAS (see all 29):

Cosmic Id	AA Change
549	p.Q61K
528	p.G13S
546	p.A59T
534	p.G13V
553	p.Q61L

5/33 SABiosciences Cancer Mutation PCR Arrays containing KRAS (see all 33):

Breast Cancer

Cancer Comprehensive Panel 384HT

Lung Cancer

Liver Cancer

2 SABiosciences qBiomarker Copy Number PCR Arrays containing KRAS:

Oncogenes & Tumor Suppressor Genes 384HC

Lung Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRAS

DNA2.0 Custom Variant and Variant Library Synthesis for KRAS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRAS for disorders           About GeneDecksing

OMIM gene information: 190070
OMIM disorders: 211980  109800  114480  260350  137215  609942  115150
UniProtKB/Swiss-Prot: RASK_HUMAN, P01116

Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in

which hematopoietic precursors are arrested in an early stage of development

Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric

myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and

2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid

progenitors to granulocyte-macrophage colony stimulating factor

Defects in KRAS are the cause of Noonan syndrome type 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950]

is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness,

motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an

estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia

(JMML). NS3 inheritance is autosomal dominant

Defects in KRAS are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or

stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the

small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to

other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that

accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and

intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of

the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal

metaplasia of the stomach, most often observed in sporadic disease

Note=Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the

brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and

malignant tumors

Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as

cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and

mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy.

Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin

lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They

include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures,

a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is

autosomal dominant

Note=KRAS mutations are involved in cancer development

20/169 diseases for KRAS (see all 169): About MalaCards

carcinoma cronkhite-canada syndrome lung adenocarcinoma adenocarcinoma

mutyh-associated polyposis monoclonal gammopathy of undetermined significance tick-borne encephalitis murray valley encephalitis

adenoma sarcoma familial adenomatous polyposis juvenile myelomonocytic leukemia

pseudomyxoma peritonei squamous cell carcinoma non-small cell lung carcinoma noonan syndrome

pulmonic stenosis myelomonocytic leukemia serous cystadenoma bone marrow cancer

20/22 diseases from the University of Copenhagen DISEASES database for KRAS (see all 22):

Colorectal cancer Carcinoma Lung cancer Pancreatic cancer

Adenoma Hepatitis C Hepatitis Melanoma

Leukemia Noonan syndrome Pancreatitis Endometrial cancer

Familial adenomatous polyposis Gallbladder cancer Hepatocellular carcinoma Yellow fever

Ovarian cancer Lynch syndrome Liver cirrhosis Dengue disease

10/94 Novoseek disease relationships for KRAS gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability	87.1	85	9921983 (3), 16429393 (3), 15118616 (2), 15481028 (2) (see all 71)
colorectal cancer	85.2	250	15069679 (5), 19712476 (4), 19832985 (4), 19515263 (4) (see all 99)
somatic mutations	80.8	42	19959798 (2), 10545700 (1), 15781646 (1), 17047397 (1) (see all 37)
nsclc	80.6	205	19787214 (6), 19789349 (6), 14601056 (6), 20145159 (5) (see all 77)
adenocarcinoma lung	78.4	68	9645349 (3), 15696205 (3), 19855375 (3), 9332768 (3) (see all 36)
adenocarcinoma	75.5	110	14511407 (4), 18075308 (4), 14724583 (4), 17360030 (4) (see all 61)
tumors	75.3	615	20145159 (5), 12893203 (5), 20010090 (5), 9921983 (5) (see all 99)
juvenile myelomonocytic leukemia	74.8	6	20471511 (1), 19066392 (1), 18561174 (1), 17332249 (1) (see all 5)
colorectal tumors	73.5	20	18602919 (3), 20020061 (2), 18259212 (2), 18632722 (1) (see all 16)
cancer lung	72.9	79	20108024 (3), 17510423 (3), 12606951 (2), 18927287 (2) (see all 52)

GeneTests: KRAS

Costello Syndrome

Cardiofaciocutaneous Syndrome

Noonan Syndrome

Genetic Association Database (GAD): KRAS
Human Genome Epidemiology (HuGE) Navigator: KRAS (400 documents)

Export disorders for KRAS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRAS gene, integrated from 9 sources (see all 1601):
(articles sorted by number of sources associating them with KRAS)

Utopia: connect your pdf to the dynamic
world of online information

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. (PubMed id 16533793)^{1, 2, 9} Tam I.Y.S.... Wong M.P. (2006)
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. (PubMed id 16110022)^{1, 4, 9} Westra J.L....Plukker J.T. (2005)
BRAF mutation in endometrial carcinoma and hyperplasi a: correlation with KRAS and p53 mutations and mismatch repair protein expressi on. (PubMed id 16144912)^{1, 4, 9} Feng Y.Z....Konishi I. (2005)
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. (PubMed id 16043828)^{1, 4, 9} Eberhard D.A....Hillan K.J. (2005)
The prevalence of PIK3CA mutations in gastric and colon cancer. (PubMed id 15994075)^{1, 4, 9} Velho S....Seruca R. (2005)
BRAF and KRAS mutations in stomach cancer. (PubMed id 14534542)^{1, 2, 9} Lee S.H....Yoo N.J. (2003)
Population-based mapping of pulmonary adenoma susceptibility 1 locus. (PubMed id 11016621)^{1, 4, 9} Dragani T.A....Nagao M. (2000)
Regulation of RAS oncogenicity by acetylation. (PubMed id 22711838)^{1, 2} Yang M.H....Haigis K.M. (2012)
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. (PubMed id 20949621)^{1, 2} Gremer L.... Ahmadian M.R. (2011)
Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. (PubMed id 19396835)^{1, 2} Kratz C.P....Zenker M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3845	HGNC: 6407	AceView: KRAS2	Ensembl:ENSG00000133703	euGenes: HUgn3845
ECgene: KRAS	Kegg: 3845	H-InvDB: KRAS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRAS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KRAS	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRAS
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=KRAS

Intellectual Property for KRAS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KRAS gene:
Search GeneIP for patents involving KRAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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KRAS Gene

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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KRAS (Gene Symbol)
V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog
KRAS2
RASK2
KRAS1
V-Ki-Ras2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
C-Ki-Ras
K-Ras 2
NS
C-K-RAS
K-RAS2A
K-RAS2B
K-RAS4A
K-RAS4B
KI-RAS
NS3
C-Kirsten-Ras Protein
Cellular C-Ki-Ras2 Proto-Oncogene
GTPase KRas
K-Ras P21 Protein
Oncogene KRAS2
PR310 C-K-Ras Oncogene
Transforming Protein P21
Ki-Ras
C-K-Ras

stable disease
Lymphoblastic Leukemia Acute Childhood
LUNG TUMOR
Neoplasms Germ Cell
familial adenomatous polyposis
pancreatic cancer metastatic
Microsatellite Instability
Retinoblastoma
dysplasia
Polyps
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Breast Cancer
NSCLC
CFC SYNDROME
primary tumor
Adenocarcinoma
Seminoma
Cancer
Colorectal Carcinoma
somatic mutations
ADENOCARCINOMA GASTRIC
Lymphoma
Carcinosarcoma
mammary tumor
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
COLON ADENOCARCINOMA
Ovarian Cancer
Colorectal Neoplasms
polyposis
Colorectal Cancer
Noonan Syndrome
Rectal Cancer
cervical squamous cell carcinoma
TUMOR LIVER
Testicular Cancer
Cysts
Cervical Cancer
Hepatitis B
ENDOMETRIAL CARCINOMA
Neurofibromatosis Type 1
prostate cancer
Tumors
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Sarcoma
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molecular pathology
Cardiofaciocutaneous Syndrome
SMOKING HABIT
COLON TUMOR
progressive disease
neoplastic transformation
JUVENILE MYELOMONOCYTIC LEUKEMIA
Gastric Cancer
Ovarian Neoplasms
BREAST CARCINOMA
Melanoma
bladder cancer
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stage III colon cancer
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Costello Syndrome
small cell lung cancer
chronic pancreatitis
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solid tumor
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Histopathology
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KRAS Gene

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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Function
for KRAS gene

Pathways & Interactions
for KRAS gene

Drugs & Compounds
for KRAS gene

Transcripts
for KRAS gene

Expression
for KRAS gene

Orthologs
for KRAS gene

Paralogs
for KRAS gene

Genomic Variants
for KRAS gene

Disorders / Diseases
for KRAS gene

Publications
for KRAS gene

Intellectual Property
for KRAS gene

Products
for KRAS gene