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Aliases for KRAS Gene

Aliases for KRAS Gene

  • Kirsten Rat Sarcoma Viral Oncogene Homolog 2 3
  • KRAS2 3 4 6
  • RASK2 3 4 6
  • V-Ki-Ras2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog 2 3
  • C-Ki-Ras 3 4
  • K-Ras 2 3 4
  • C-K-RAS 3 4
  • KI-RAS 3 4
  • CFC2 3 6
  • NS 3 6
  • V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog 2
  • Cellular C-Ki-Ras2 Proto-Oncogene 3
  • Transforming Protein P21 3
  • PR310 C-K-Ras Oncogene 3
  • C-Kirsten-Ras Protein 3
  • K-Ras P21 Protein 3
  • Oncogene KRAS2 3
  • GTPase KRas 3
  • K-RAS2A 3
  • K-RAS2B 3
  • K-RAS4A 3
  • K-RAS4B 3
  • KRAS1 3
  • NS3 3

External Ids for KRAS Gene

Previous Symbols for KRAS Gene

  • KRAS2

Summaries for KRAS Gene

Entrez Gene Summary for KRAS Gene

  • This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRAS Gene

KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with KRAS include noonan syndrome 3 and cardiofaciocutaneous syndrome 2. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for KRAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838).

Gene Wiki entry for KRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRAS Gene

Genomics for KRAS Gene

Genomic Location for KRAS Gene

Start:
25,204,789 bp from pter
End:
25,250,936 bp from pter
Size:
46,148 bases
Orientation:
Minus strand

Genomic View for KRAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRAS Gene

Regulatory Elements for KRAS Gene

Transcription factor binding sites by QIAGEN in the KRAS gene promoter:

Proteins for KRAS Gene

  • Protein details for KRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01116-RASK_HUMAN
    Recommended name:
    GTPase KRas
    Protein Accession:
    P01116
    Secondary Accessions:
    • A8K8Z5
    • B0LPF9
    • P01118
    • Q96D10

    Protein attributes for KRAS Gene

    Size:
    189 amino acids
    Molecular mass:
    21656 Da
    Quaternary structure:
    • Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (PubMed:23698361). Interacts with SOS1 (PubMed:22431598).

    Three dimensional structures from OCA and Proteopedia for KRAS Gene

    Alternative splice isoforms for KRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRAS Gene

Proteomics data for KRAS Gene at MOPED

Post-translational modifications for KRAS Gene

  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys88, Lys117, and Lys128

Other Protein References for KRAS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KRAS Gene

Domains for KRAS Gene

Suggested Antigen Peptide Sequences for KRAS Gene

Graphical View of Domain Structure for InterPro Entry

P01116

UniProtKB/Swiss-Prot:

RASK_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • P01116
genes like me logo Genes that share domains with KRAS: view

No data available for Gene Families for KRAS Gene

Function for KRAS Gene

Molecular function for KRAS Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.
UniProtKB/Swiss-Prot Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838).

Gene Ontology (GO) - Molecular Function for KRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 12732644
GO:0005525 GTP binding IEA --
GO:0019002 GMP binding IEA --
GO:0019003 GDP binding IEA --
genes like me logo Genes that share ontologies with KRAS: view
genes like me logo Genes that share phenotypes with KRAS: view

Animal Models for KRAS Gene

MGI Knock Outs for KRAS:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KRAS Gene

Localization for KRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRAS Gene COMPARTMENTS Subcellular localization image for KRAS gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 23698361
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KRAS: view

Pathways for KRAS Gene

SuperPathways for KRAS Gene

Superpath Contained pathways
1 Signaling by FGFR
2 IL-2 Pathway
3 Insulin receptor signalling cascade
4 SHC1 events in ERBB2 signaling
5 IL-9 Signaling Pathways
genes like me logo Genes that share pathways with KRAS: view

Pathways by source for KRAS Gene

Gene Ontology (GO) - Biological Process for KRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001934 positive regulation of protein phosphorylation IMP 22065586
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006184 obsolete GTP catabolic process --
genes like me logo Genes that share ontologies with KRAS: view

Compounds for KRAS Gene

(1) HMDB Compounds for KRAS Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Drugbank Compounds for KRAS Gene

(37) Novoseek inferred chemical compound relationships for KRAS Gene

Compound -log(P) Hits PubMed IDs
panitumumab 92.6 62
cetuximab 91.6 123
erlotinib 84.3 21
gefitinib 81.3 23
crcs 80.3 18

(3) PharmGKB related drug/compound annotations for KRAS Gene

Drug/compound Annotation
cetuximab CA
panitumumab CA
regorafenib
genes like me logo Genes that share compounds with KRAS: view

Transcripts for KRAS Gene

Unigene Clusters for KRAS Gene

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRAS Gene

No ASD Table

Relevant External Links for KRAS Gene

GeneLoc Exon Structure for
KRAS
ECgene alternative splicing isoforms for
KRAS

Expression for KRAS Gene

mRNA expression in normal human tissues for KRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KRAS Gene

SOURCE GeneReport for Unigene cluster for KRAS Gene Hs.505033

genes like me logo Genes that share expressions with KRAS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KRAS Gene

Orthologs for KRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRAS 35
  • 99.82 (n)
  • 100 (a)
KRAS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRAS 35
  • 95.21 (n)
  • 97.01 (a)
KRAS 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia K-RAS 36
  • 91 (a)
OneToOne
KRAS 35
  • 98.59 (n)
  • 98.94 (a)
mouse
(Mus musculus)
Mammalia Kras 35
  • 87.06 (n)
  • 88.83 (a)
Kras 16
Kras 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
KRAS 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KRAS 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kras 35
  • 87.77 (n)
  • 89.36 (a)
chicken
(Gallus gallus)
Aves KRAS 35
  • 83.69 (n)
  • 90.96 (a)
KRAS 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24980 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485959 35
  • 80.95 (n)
  • 97.88 (a)
zebrafish
(Danio rerio)
Actinopterygii kras 35
  • 74.82 (n)
  • 88.3 (a)
kras 36
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002219 35
  • 69.7 (n)
  • 85.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 35
  • 70.71 (n)
  • 85.45 (a)
Ras85D 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-60 35
  • 65.58 (n)
  • 76.63 (a)
let-60 36
  • 76 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 35 (a)
ManyToMany
RAS2 36
  • 34 (a)
ManyToMany
Species with no ortholog for KRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KRAS Gene

ENSEMBL:
Gene Tree for KRAS (if available)
TreeFam:
Gene Tree for KRAS (if available)

Paralogs for KRAS Gene

Paralogs for KRAS Gene

Pseudogenes.org Pseudogenes for KRAS Gene

genes like me logo Genes that share paralogs with KRAS: view

Variants for KRAS Gene

Sequence variations from dbSNP and Humsavar for KRAS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs712 -- 25,209,618(-) TCCTC(G/T)AAGTG utr-variant-3-prime, downstream-variant-500B
rs8720 -- 25,206,009(-) TAATG(A/G)TTTCT utr-variant-3-prime
rs9266 -- 25,209,283(-) CCTGA(C/T)GAATG utr-variant-3-prime
rs12245 -- 25,205,716(-) GCAGA(A/T)ATGTT utr-variant-3-prime
rs12587 -- 25,205,894(-) GAGAA(A/C)CTGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRAS Gene

Variant ID Type Subtype PubMed ID
nsv898922 CNV Loss 21882294
dgv1394n71 CNV Loss 21882294
nsv470279 CNV Gain 18288195
nsv898927 CNV Loss 21882294
nsv522233 CNV Loss 19592680

Relevant External Links for KRAS Gene

HapMap Linkage Disequilibrium report
KRAS
Human Gene Mutation Database (HGMD)
KRAS
Locus Specific Mutation Databases (LSDB)
KRAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRAS Gene

Disorders for KRAS Gene

(8) OMIM Diseases for KRAS Gene (190070)

UniProtKB/Swiss-Prot

RASK_HUMAN
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. {ECO:0000269 PubMed:8955068}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Noonan syndrome 3 (NS3) [MIM:609942]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:16474405, ECO:0000269 PubMed:16773572, ECO:0000269 PubMed:17056636, ECO:0000269 PubMed:17468812, ECO:0000269 PubMed:19396835}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:14534542, ECO:0000269 PubMed:3034404, ECO:0000269 PubMed:7773929}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.
  • Cardiofaciocutaneous syndrome 2 (CFC2) [MIM:615278]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. CFC2 patients often do not have the skin abnormalities, such as ichthyosis, hyperkeratosis, and hemangioma observed in CFC1. {ECO:0000269 PubMed:16474404, ECO:0000269 PubMed:16474405, ECO:0000269 PubMed:17056636, ECO:0000269 PubMed:21797849}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=KRAS mutations are involved in cancer development.

(94) Novoseek inferred disease relationships for KRAS Gene

Disease -log(P) Hits PubMed IDs
microsatellite instability 87.1 83
colorectal cancer 85.2 167
somatic mutations 80.8 38
nsclc 80.6 141
adenocarcinoma lung 78.4 57

Relevant External Links for KRAS

GeneTests
KRAS
GeneReviews
KRAS
Genetic Association Database (GAD)
KRAS
Human Genome Epidemiology (HuGE) Navigator
KRAS
genes like me logo Genes that share disorders with KRAS: view

Publications for KRAS Gene

  1. Population-based mapping of pulmonary adenoma susceptibility 1 locus. (PMID: 11016621) Dragani T.A. … Nagao M. (Cancer Res. 2000) 3 23 48
  2. BRAF and KRAS mutations in stomach cancer. (PMID: 14534542) Lee S.H. … Yoo N.J. (Oncogene 2003) 3 4 23
  3. The prevalence of PIK3CA mutations in gastric and colon cancer. (PMID: 15994075) Velho S. … Seruca R. (Eur. J. Cancer 2005) 3 23 48
  4. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. (PMID: 16043828) Eberhard D.A. … Hillan K.J. (J. Clin. Oncol. 2005) 3 23 48
  5. BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression. (PMID: 16144912) Feng Y.Z. … Konishi I. (Clin. Cancer Res. 2005) 3 23 48

Products for KRAS Gene

  • Addgene plasmids for KRAS

Sources for KRAS Gene

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