KPRP Gene
protein-coding GIFtS: 39
GCID: GC01P152730
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keratinocyte proline-rich protein(Previous name: chromosome 1 open reading frame 45 )
(Previous symbol: C1orf45)
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Aliases
for KPRP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratinocyte Proline-Rich Protein1 2 | | C1orf451 2 3 | | HKPRP1 | | Chromosome 1 Open Reading Frame 451 | | Keratinocyte Expressed, Proline-Rich Protein2 |
Export aliases for KPRP gene to outside databasesPrevious GC identifers: GC01P150998 GC01P124103 |
Summaries
for KPRP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KPRP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KPRP gene promoter:
Oct-B1 Max1 HFH-3 oct-B2 oct-B3 FOXI1 FOXO4 FOXJ2 (long isoform) FOXJ2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KPRP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPRP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3KPRP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P152730: view genomic region
(about GC identifiers)
Start:
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152,730,506 bp from pter |
End:
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152,734,529 bp from pter |
Size:
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4,024 bases |
Orientation:
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plus strand |
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Proteins
for KPRP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KPRP_HUMAN, Q5T749 (See
protein sequence)Recommended Name: Keratinocyte proline-rich protein Size: 579 amino acids; 64136 Da
Subcellular location: Cytoplasm (By similarity)
Developmental stage: Expressed in the periderm of fetal skin from 16th week gestational age and in the granular andhorny layers of the epidermis at 24th week gestational age and thereafter (at protein level)Explore the universe of human proteins at neXtProt for KPRP: NX_Q5T749
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T749
KPRP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020402.1
ENSEMBL proteins: ENSP00000357762
Human Recombinant Protein Products for KPRP:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
KPRP for ontologies About GeneDecksing
KPRP Antibody Products:
Assay Products for KPRP: |
Protein
Domains /
Families
for KPRP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5T749 |
Function
for KPRP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KPRP_HUMAN, Q5T749Induction: By calcium and in psoriatic lesionsPhenotypes:
1 GenomeRNAi human phenotype for KPRP:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KPRP (NM_001025231) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPRP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPRP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPRP |
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Pathways & Interactions
for KPRP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KPRP
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KPRP (ENSP000003577624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for KPRP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KPRP
1 HMDB Compound for KPRP About this table
Search CenterWatch for drugs/clinical trials and news about KPRP
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Transcripts
for KPRP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KPRP gene: NM_001025231.1 Unigene Cluster for KPRP: Keratinocyte proline-rich protein Hs.149386 [show with all ESTs]Unigene Representative Sequence: NM_0010252311 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368773(uc001fal.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KPRP (NM_001025231) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPRP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPRP |
Additional cDNA sequence: AY960854.1 1 DOTS entry: DT.75150109
GeneLoc Exon Structure
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Expression
for KPRP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KPRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACAATAAA
About this image
See KPRP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.149386
UniProtKB/Swiss-Prot: KPRP_HUMAN, Q5T749Tissue specificity: Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upperlayer of epidermis and psoriasis
SABiosciences Custom PCR Arrays for KPRP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPRP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KPRP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPRP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPRP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPRP |
Orthologs
for KPRP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KPRP gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for KPRP (if available)
TreeFam Gene Tree for KPRP (if available) |
Paralogs
for KPRP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KPRP gene
- C1orf682
KPRP for paralogs About GeneDecksing
|
Genomic Variants
for KPRP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KPRP (152730506 - 152734529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for KPRP
6 CNVs: 9374 3314 8334 74716 6786 2328 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPRP |
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Disorders
/ Diseases
for KPRP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KPRP for disorders About GeneDecksing
OMIM gene information: 613260
OMIM disorders: --
5  diseases for KPRP: About MalaCardscorticobasal degeneration pick's disease alzheimer's disease psoriasis
neuronitis
Export disorders for KPRP gene to outside databases
|
Publications
for KPRP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KPRP gene integrated from 9 sources:
(articles sorted by number of sources associating them with KPRP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes. (PubMed id 16297201)1, 2, 3 Lee W.-H.... Lee J.-H. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for KPRP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KPRP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KPRP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KPRP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KPRP | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KPRP gene:
Search GeneIP for patents involving KPRP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KPRP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KPRP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPRP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPRP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KPRP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPRP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KPRP | | OriGene Custom Protein Services for KPRP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPRP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPRP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPRP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPRP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPRP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPRP |
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 |  |  |  | |
| | | | Search Tocris compounds for KPRP |
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 | | | KPRP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPRP |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KPRP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPRP |
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