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Aliases for KPRP Gene

Aliases for KPRP Gene

  • Keratinocyte Proline-Rich Protein 2 3
  • C1orf45 3 4
  • HKPRP 3 4
  • Keratinocyte Expressed, Proline-Rich Protein 3
  • Chromosome 1 Open Reading Frame 45 2

External Ids for KPRP Gene

Previous HGNC Symbols for KPRP Gene

  • C1orf45

Previous GeneCards Identifiers for KPRP Gene

  • GC01P150998
  • GC01P152730
  • GC01P124103

Summaries for KPRP Gene

GeneCards Summary for KPRP Gene

KPRP (Keratinocyte Proline-Rich Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPRP Gene

Genomics for KPRP Gene

Regulatory Elements for KPRP Gene

Genomic Location for KPRP Gene

152,758,030 bp from pter
152,762,053 bp from pter
4,024 bases
Plus strand

Genomic View for KPRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPRP Gene

Proteins for KPRP Gene

  • Protein details for KPRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte proline-rich protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KPRP Gene

    579 amino acids
    Molecular mass:
    64136 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KPRP Gene

Proteomics data for KPRP Gene at MOPED

Post-translational modifications for KPRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPRP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KPRP Gene

Domains for KPRP Gene

Protein Domains for KPRP Gene


Suggested Antigen Peptide Sequences for KPRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KPRP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KPRP Gene

Function for KPRP Gene

Molecular function for KPRP Gene

UniProtKB/Swiss-Prot Induction:
By calcium and in psoriatic lesions.

Phenotypes for KPRP Gene

GenomeRNAi human phenotypes for KPRP:
genes like me logo Genes that share phenotypes with KPRP: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KPRP Gene

Localization for KPRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPRP Gene


Subcellular locations from

Jensen Localization Image for KPRP Gene COMPARTMENTS Subcellular localization image for KPRP gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KPRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KPRP: view

Pathways for KPRP Gene

SuperPathways for KPRP Gene

No Data Available

Interacting Proteins for KPRP Gene

Gene Ontology (GO) - Biological Process for KPRP Gene


No data available for Pathways by source for KPRP Gene

Drugs for KPRP Gene

(1) HMDB Compounds for KPRP Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with KPRP: view

Transcripts for KPRP Gene

mRNA/cDNA for KPRP Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KPRP Gene

Keratinocyte proline-rich protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPRP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPRP Gene

No ASD Table

Relevant External Links for KPRP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KPRP Gene

mRNA expression in normal human tissues for KPRP Gene

mRNA differential expression in normal tissues according to GTEx for KPRP Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (31.4) and Skin - Not Sun Exposed (Suprapubic) (16.0).

Protein differential expression in normal tissues for KPRP Gene

This gene is overexpressed in Cervix (19.2), Urinary Bladder (13.1), and Bone (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for KPRP Gene

SOURCE GeneReport for Unigene cluster for KPRP Gene Hs.149386

mRNA Expression by UniProt/SwissProt for KPRP Gene

Tissue specificity: Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.
genes like me logo Genes that share expressions with KPRP: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for KPRP Gene

Orthologs for KPRP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KPRP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KPRP 35
  • 78.53 (n)
  • 70.28 (a)
  • 67 (a)
(Canis familiaris)
Mammalia KPRP 35
  • 77.1 (n)
  • 68.17 (a)
(Mus musculus)
Mammalia Kprp 35
  • 71.51 (n)
  • 63.44 (a)
Kprp 16
Kprp 36
  • 55 (a)
(Pan troglodytes)
Mammalia KPRP 35
  • 99.31 (n)
  • 98.79 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Kprp 35
  • 69.92 (n)
  • 62.94 (a)
Species with no ortholog for KPRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KPRP Gene

Gene Tree for KPRP (if available)
Gene Tree for KPRP (if available)

Paralogs for KPRP Gene

No data available for Paralogs for KPRP Gene

Variants for KPRP Gene

Sequence variations from dbSNP and Humsavar for KPRP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1412548 -- 152,758,180(+) GGTGC(A/G)TTAAC intron-variant
rs1831641 -- 152,757,199(+) TATTA(C/T)ACTTT upstream-variant-2KB
rs4329520 - 152,760,825(+) AACCA(A/T)GCATA missense, reference
rs6658215 -- 152,762,346(+) atcaa(C/T)ttgac downstream-variant-500B
rs6703294 - 152,761,182(+) GTGGC(A/C)CATCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KPRP Gene

Variant ID Type Subtype PubMed ID
dgv131e1 CNV Complex 17122850
esv33483 CNV Gain+Loss 17666407
esv34854 CNV Gain 17911159
nsv818478 CNV Gain 17921354
essv16576 CNV CNV 17122850
nsv508615 CNV Loss 20534489

Relevant External Links for KPRP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPRP Gene

Disorders for KPRP Gene

No disorders were found for KPRP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KPRP Gene

Publications for KPRP Gene

  1. Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes. (PMID: 16297201) Lee W.-H. … Lee J.-H. (J. Invest. Dermatol. 2005) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PMID: 21319273) Neganova I. … Lako M. (Stem Cells 2011) 3

Products for KPRP Gene

Sources for KPRP Gene

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