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Aliases for KPRP Gene

Aliases for KPRP Gene

  • Keratinocyte Proline Rich Protein 2 3 5
  • Keratinocyte Proline-Rich Protein 2 3
  • C1orf45 3 4
  • Keratinocyte Expressed, Proline-Rich Protein 3
  • Chromosome 1 Open Reading Frame 45 2
  • HKPRP 4

External Ids for KPRP Gene

Previous HGNC Symbols for KPRP Gene

  • C1orf45

Previous GeneCards Identifiers for KPRP Gene

  • GC01P150998
  • GC01P152730
  • GC01P124103
  • GC01P152759

Summaries for KPRP Gene

Entrez Gene Summary for KPRP Gene

  • This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. [provided by RefSeq, Jul 2016]

GeneCards Summary for KPRP Gene

KPRP (Keratinocyte Proline Rich Protein) is a Protein Coding gene.

Additional gene information for KPRP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPRP Gene

Genomics for KPRP Gene

Regulatory Elements for KPRP Gene

Enhancers for KPRP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H152745 0.7 ENCODE 0.4 -12.5 -12461 0 CTCF FOXA2 L3MBTL2 BHLHE40 CEBPB MAX USF2 CEBPG ZNF644 RAD51 LCE1F C1orf68 LCEP1 KPRP
GH01H152752 0.5 ENCODE 0.4 -5.6 -5611 0 FOXA2 MNT FOS FOXA1 LCE1D KPRP LCEP1
GH01H152768 0.5 ENCODE 0.4 +11.4 11352 0 CEBPB CEBPG EP300 LCE1F KPRP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KPRP on UCSC Golden Path with GeneCards custom track

Genomic Location for KPRP Gene

152,758,030 bp from pter
152,762,053 bp from pter
4,024 bases
Plus strand

Genomic View for KPRP Gene

Genes around KPRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPRP Gene

Proteins for KPRP Gene

  • Protein details for KPRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte proline-rich protein
    Protein Accession:

    Protein attributes for KPRP Gene

    579 amino acids
    Molecular mass:
    64136 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KPRP Gene

Post-translational modifications for KPRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPRP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KPRP Gene

Domains & Families for KPRP Gene

Gene Families for KPRP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KPRP Gene


Suggested Antigen Peptide Sequences for KPRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KPRP: view

No data available for UniProtKB/Swiss-Prot for KPRP Gene

Function for KPRP Gene

Molecular function for KPRP Gene

UniProtKB/Swiss-Prot Induction:
By calcium and in psoriatic lesions.

Gene Ontology (GO) - Molecular Function for KPRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27107012
genes like me logo Genes that share ontologies with KPRP: view
genes like me logo Genes that share phenotypes with KPRP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KPRP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KPRP Gene

Localization for KPRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPRP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPRP gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KPRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KPRP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KPRP Gene

Pathways & Interactions for KPRP Gene

No Data Available

Interacting Proteins for KPRP Gene

Gene Ontology (GO) - Biological Process for KPRP Gene


No data available for Pathways by source and SIGNOR curated interactions for KPRP Gene

Drugs & Compounds for KPRP Gene

(1) Drugs for KPRP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with KPRP: view

Transcripts for KPRP Gene

mRNA/cDNA for KPRP Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KPRP Gene

Keratinocyte proline-rich protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KPRP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KPRP Gene

No ASD Table

Relevant External Links for KPRP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KPRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KPRP Gene

mRNA differential expression in normal tissues according to GTEx for KPRP Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x31.4) and Skin - Not Sun Exposed (Suprapubic) (x16.0).

Protein differential expression in normal tissues from HIPED for KPRP Gene

This gene is overexpressed in Cervix (19.2), Urinary Bladder (13.1), and Bone (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KPRP Gene

NURSA nuclear receptor signaling pathways regulating expression of KPRP Gene:


SOURCE GeneReport for Unigene cluster for KPRP Gene:


mRNA Expression by UniProt/SwissProt for KPRP Gene:

Tissue specificity: Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.

Evidence on tissue expression from TISSUES for KPRP Gene

  • Skin(3.5)
genes like me logo Genes that share expression patterns with KPRP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPRP Gene

Orthologs for KPRP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KPRP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KPRP 33 34
  • 99.31 (n)
(Bos Taurus)
Mammalia KPRP 33 34
  • 78.53 (n)
(Canis familiaris)
Mammalia KPRP 33
  • 77.1 (n)
(Mus musculus)
Mammalia Kprp 33 16 34
  • 71.51 (n)
(Rattus norvegicus)
Mammalia Kprp 33
  • 69.92 (n)
Species where no ortholog for KPRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KPRP Gene

Gene Tree for KPRP (if available)
Gene Tree for KPRP (if available)

Paralogs for KPRP Gene

No data available for Paralogs for KPRP Gene

Variants for KPRP Gene

Sequence variations from dbSNP and Humsavar for KPRP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920890 Uncertain significance 152,760,413(+) CGTTT(A/T)GAGCC reference, missense
rs193921023 Uncertain significance 152,760,331(+) GCACC(A/G)CTCTC reference, missense
rs1000067276 -- 152,757,758(+) CCCGA(C/T)CATCA upstream-variant-2KB
rs1000105056 -- 152,758,975(+) TGTAT(C/G)ATGTT intron-variant
rs1000136427 -- 152,759,239(+) TACTT(C/G)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPRP Gene

Variant ID Type Subtype PubMed ID
esv2758970 CNV gain+loss 17122850
esv2763813 CNV loss 21179565
esv33483 CNV gain+loss 17666407
esv34854 CNV gain 17911159
nsv1000648 CNV gain 25217958
nsv1004884 CNV gain 25217958
nsv508615 CNV deletion 20534489
nsv547891 CNV loss 21841781
nsv547899 CNV gain 21841781
nsv818478 CNV gain 17921354

Variation tolerance for KPRP Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.93; 97.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPRP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPRP Gene

Disorders for KPRP Gene

Relevant External Links for KPRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KPRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPRP Gene

Publications for KPRP Gene

  1. Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes. (PMID: 16297201) Lee WH … Lee JH (The Journal of investigative dermatology 2005) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for KPRP Gene

Sources for KPRP Gene

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