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Aliases for KPNB1 Gene

Aliases for KPNB1 Gene

  • Karyopherin (Importin) Beta 1 2 3
  • Pore Targeting Complex 97 KDa Subunit 3 4
  • Karyopherin Subunit Beta-1 3 4
  • Nuclear Factor P97 3 4
  • Importin-90 3 4
  • Importin 1 2 3
  • PTAC97 3 4
  • NTF97 3 4
  • Importin Beta-1 Subunit 3
  • Importin Subunit Beta-1 3
  • Importin 90 3
  • Impnb 3
  • IMB1 3
  • IPO1 3
  • IPOB 3

External Ids for KPNB1 Gene

Previous GeneCards Identifiers for KPNB1 Gene

  • GC17P045432
  • GC17P048207
  • GC17P046069
  • GC17P046201
  • GC17P043082
  • GC17P045727
  • GC17P041096

Summaries for KPNB1 Gene

Entrez Gene Summary for KPNB1 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KPNB1 Gene

KPNB1 (Karyopherin (Importin) Beta 1) is a Protein Coding gene. Diseases associated with KPNB1 include campomelic dysplasia. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein domain specific binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for KPNB1 Gene

  • Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Gene Wiki entry for KPNB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNB1 Gene

Genomics for KPNB1 Gene

Regulatory Elements for KPNB1 Gene

Genomic Location for KPNB1 Gene

Start:
47,649,476 bp from pter
End:
47,685,505 bp from pter
Size:
36,030 bases
Orientation:
Plus strand

Genomic View for KPNB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNB1 Gene

Proteins for KPNB1 Gene

  • Protein details for KPNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14974-IMB1_HUMAN
    Recommended name:
    Importin subunit beta-1
    Protein Accession:
    Q14974
    Secondary Accessions:
    • B7ZAV6
    • D3DTT3
    • Q14637
    • Q53XN2
    • Q96J27

    Protein attributes for KPNB1 Gene

    Size:
    876 amino acids
    Molecular mass:
    97170 Da
    Quaternary structure:
    • Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory syncytial virus (HRSV) protein M. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8.

    Three dimensional structures from OCA and Proteopedia for KPNB1 Gene

    Alternative splice isoforms for KPNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KPNB1 Gene

Proteomics data for KPNB1 Gene at MOPED

Post-translational modifications for KPNB1 Gene

  • Mono-ADP-ribosylated by PARP16
  • Ubiquitination at Lys23, Lys62, Lys206, Lys376, Lys537, Lys651, Lys730, Lys835, Lys859, and Lys867
  • Modification sites at PhosphoSitePlus

Other Protein References for KPNB1 Gene

No data available for DME Specific Peptides for KPNB1 Gene

Domains for KPNB1 Gene

Gene Families for KPNB1 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • IPO :Importins

Suggested Antigen Peptide Sequences for KPNB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14974

UniProtKB/Swiss-Prot:

IMB1_HUMAN :
  • Q14974
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family. Importin beta-1 subfamily.
Similarity:
  • Contains 19 HEAT repeats.
genes like me logo Genes that share domains with KPNB1: view

Function for KPNB1 Gene

Molecular function for KPNB1 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Gene Ontology (GO) - Molecular Function for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 11311162
GO:0008139 nuclear localization sequence binding TAS 7627554
GO:0008270 zinc ion binding TAS 7615630
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with KPNB1: view
genes like me logo Genes that share phenotypes with KPNB1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KPNB1 Gene

Localization for KPNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNB1 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNB1 Gene COMPARTMENTS Subcellular localization image for KPNB1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IDA 22701565
GO:0005643 nuclear pore TAS 7627554
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KPNB1: view

Pathways for KPNB1 Gene

genes like me logo Genes that share pathways with KPNB1: view

Gene Ontology (GO) - Biological Process for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation TAS 7615630
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006606 protein import into nucleus IDA 15964792
GO:0006607 NLS-bearing protein import into nucleus TAS 7627554
GO:0006610 ribosomal protein import into nucleus IDA 9687515
genes like me logo Genes that share ontologies with KPNB1: view

Compounds for KPNB1 Gene

(1) HMDB Compounds for KPNB1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for KPNB1 Gene

Compound -log(P) Hits PubMed IDs
gtp 27.6 1
genes like me logo Genes that share compounds with KPNB1: view

Transcripts for KPNB1 Gene

Unigene Clusters for KPNB1 Gene

Karyopherin (importin) beta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - - - - -
SP11:
SP12: - - - - - - - -
SP13: - -
SP14:

ExUns: 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KPNB1 Gene

GeneLoc Exon Structure for
KPNB1
ECgene alternative splicing isoforms for
KPNB1

Expression for KPNB1 Gene

mRNA expression in normal human tissues for KPNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNB1 Gene

SOURCE GeneReport for Unigene cluster for KPNB1 Gene Hs.532793

genes like me logo Genes that share expressions with KPNB1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KPNB1 Gene

Orthologs for KPNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNB1 35
  • 99.64 (n)
  • 100 (a)
KPNB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNB1 35
  • 95.28 (n)
  • 99.43 (a)
KPNB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNB1 35
  • 94.56 (n)
  • 99.43 (a)
KPNB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpnb1 35
  • 91.97 (n)
  • 99.2 (a)
Kpnb1 16
Kpnb1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNB1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNB1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpnb1 35
  • 91.73 (n)
  • 98.63 (a)
chicken
(Gallus gallus)
Aves KPNB1 35
  • 82.87 (n)
  • 94.88 (a)
KPNB1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNB1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpnb1 35
  • 79.87 (n)
  • 95.09 (a)
Str.2859 35
zebrafish
(Danio rerio)
Actinopterygii kpnb1 35
  • 77.47 (n)
  • 92.01 (a)
kpnb1 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009921 35
  • 60.77 (n)
  • 64.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fs(2)Ket 35
  • 59.3 (n)
  • 61.86 (a)
Fs(2)Ket 36
  • 61 (a)
OneToOne
Fs(2)Ket 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea imb-1 35
  • 52.91 (n)
  • 48.97 (a)
imb-1 36
  • 47 (a)
OneToOne
imb-1 37
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL187W 35
  • 46.7 (n)
  • 36.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP95 35
  • 47.2 (n)
  • 35.19 (a)
KAP95 36
  • 34 (a)
OneToOne
KAP95 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05665g 35
  • 48.32 (n)
  • 37.62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53480 35
  • 50.1 (n)
  • 40.73 (a)
rice
(Oryza sativa)
Liliopsida Os12g0568800 35
  • 50.94 (n)
  • 43.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20906 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02011 35
  • 49.46 (n)
  • 41.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap95 35
  • 50.06 (n)
  • 41.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6563 36
  • 61 (a)
OneToOne
Species with no ortholog for KPNB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KPNB1 Gene

ENSEMBL:
Gene Tree for KPNB1 (if available)
TreeFam:
Gene Tree for KPNB1 (if available)

Paralogs for KPNB1 Gene

Pseudogenes.org Pseudogenes for KPNB1 Gene

genes like me logo Genes that share paralogs with KPNB1: view

No data available for Paralogs for KPNB1 Gene

Variants for KPNB1 Gene

Sequence variations from dbSNP and Humsavar for KPNB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1136612 -- 47,656,868(+) TTGCA(C/G)ACATT utr-variant-5-prime, missense, reference
rs1136613 -- 47,658,609(+) GCTAC(A/G)AATGC synonymous-codon, reference
rs1136614 -- 47,673,102(+) TGTTA(C/T)CCTGC synonymous-codon, reference
rs1136638 -- 47,683,080(+) GCAGC(A/C)CAAGA utr-variant-3-prime
rs2317825 -- 47,653,135(+) TAATT(G/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNB1 Gene

Variant ID Type Subtype PubMed ID
nsv525267 CNV Gain 19592680
dgv987e1 CNV Complex 17122850
nsv428344 CNV Gain 18775914
essv3532 CNV CNV 17122850

Relevant External Links for KPNB1 Gene

HapMap Linkage Disequilibrium report
KPNB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNB1 Gene

Disorders for KPNB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KPNB1 Gene including...

Search for KPNB1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for KPNB1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for KPNB1

Genetic Association Database (GAD)
KPNB1
Human Genome Epidemiology (HuGE) Navigator
KPNB1
genes like me logo Genes that share disorders with KPNB1: view

No data available for UniProtKB/Swiss-Prot for KPNB1 Gene

Publications for KPNB1 Gene

  1. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. (PMID: 7627554) Goerlich D. … Prehn S. (Curr. Biol. 1995) 2 3 4 23
  2. Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. (PMID: 12504010) Cingolani G. … Gerace L. (Mol. Cell 2002) 3 4 23
  3. Sequence and characterization of cytoplasmic nuclear protein import factor p97. (PMID: 7615630) Chi N.C. … Adam S.A. (J. Cell Biol. 1995) 2 3 4
  4. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. (PMID: 9891055) Truant R. … Cullen B.R. (Mol. Cell. Biol. 1999) 3 4
  5. Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. (PMID: 9891056) Palmeri D. … Malim M.H. (Mol. Cell. Biol. 1999) 3 4

Products for KPNB1 Gene

Sources for KPNB1 Gene

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