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Aliases &
Descriptions
for KPNB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| IMB1 1, 2 | | IPO1 1, 2 | | IPOB 1, 2 | | Impnb 1, 2 | | Importin-90 3 | | MGC2155 1, 2 | | MGC2156 1, 2 | | MGC2157 1, 2 | | NTF97 1, 2, 3 |
| | | Descriptions |
|---|
| Karyopherin subunit beta-1 3 | | Nuclear factor P97 2, 3 | | importin 1 2 | | importin 90 2 | | importin beta-1 subunit 2 | | karyopherin (importin) beta 1 2 | | karyopherin beta 1 2 |
|
| |
Search outside databases for aliases for KPNB1 genePrevious GC identifers: GC17P045432 GC17P048207 GC17P046069 GC17P046201 |
Summaries
for KPNB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KPNB1:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear
pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear
localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and
beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the
cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex.
In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex
moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters
the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions
between importin beta and the FG repeats of nucleoporins are essential in translocation through
the pore complex. The protein encoded by this gene is a member of the importin beta family.
[provided by RefSeq]
UniProtKB/Swiss-Prot: IMB1_HUMAN, Q14974Function: Functions in nuclear protein import, either in association with an adapter protein, like
an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates,
or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS
receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated
by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the
nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor
binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1
histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1
infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleusGene Wiki entry for KPNB1 |
Genomic Location
for KPNB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the KPNB1 gene 
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32KPNB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P043082:
(about GC identifiers)
Start:
|
43,082,274 bp from pter |
End:
|
43,116,003 bp from pter |
Size:
|
33,730 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010783.14
| Proteins
for KPNB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: IMB1_HUMAN, Q14974 (See
protein sequence)Recommended Name: Importin subunit beta-1 Size: 876 amino acids; 97170 Da
Subunit: Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts
with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts
with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed
of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of
KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with
SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory
syncytial virus (HRSV) protein M
Subcellular location: Cytoplasm. Nucleus envelope
PDB structures from  and Proteopedia  :1F59 (3D)
1IBR (3D)
1M5N (3D)
1O6O (3D)
1O6P (3D)
1QGK (3D)
1QGR (3D)
2P8Q (3D)
2Q5D (3D)
2QNA (3D)
Secondary accessions: Q14637 Q96J27Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002256.2
ENSEMBL proteins: ENSP00000290158
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KPNB1:
Assays for KPNB1: | Protein
Domains/
Families
for KPNB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14974
ProtoNet protein and cluster: Q14974 3 Blocks protein families: IPB000225 Armadillo repeat IPB000357 HEAT repeat IPB001494 Importin-beta
UniProtKB/Swiss-Prot: IMB1_HUMAN, Q14974Similarity: Belongs to the importin beta familySimilarity: Contains 8 HEAT repeatsSimilarity: Contains 1 importin N-terminal domain | Gene Function
for KPNB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002265
 Applied Biosystems Silencer® siRNAs for KPNB1
 Sigma-Aldrich siRNA for KPNB1
Sigma-Aldrich shRNA for KPNB1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002265
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002265
untagged cDNA clone in CMV expression vector: NM_002265
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002265
UniProtKB/Swiss-Prot: IMB1_HUMAN, Q14974Function: Functions in nuclear protein import, either in association with an adapter protein, like
an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates,
or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS
receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated
by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the
nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor
binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1
histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1
infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kpnb1):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for KPNB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for KPNB1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for KPNB1
5/94 Interacting proteins for KPNB1 (ENSP000002901583 Q149741, 2) via UniProtKB, MINT, and/or STRING (see all 94
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000059 | protein import into nucleus, docking |
IEA | -- | | GO:0000060 | protein import into nucleus, translocation |
TAS | 7615630 | | GO:0006607 | NLS-bearing substrate import into nucleus |
TAS | 7627554 | | GO:0006610 | ribosomal protein import into nucleus |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
IEA | -- |
About this table
|
Drugs & Compounds
for KPNB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KPNB1
1  Novoseek chemical compound relationship for KPNB1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
29.74 |
1 |
10473610 (1) |
About this table
|
Transcripts
for KPNB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002265
Sigma-Aldrich siRNA for KPNB1
Sigma-Aldrich shRNA for KPNB1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002265 REFSEQ mRNAs for KPNB1 gene: NM_002265.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002265
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002265
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002265
untagged cDNA clone in CMV expression vector: NM_002265
Additional cDNA sequence: L39924.1 24/48 DOTS entries (see all 48
): DT.95235476 DT.75168063 DT.100045495 DT.95183118 DT.95280851 DT.100045493 DT.99928735 DT.100696829 DT.95371635 DT.100807075 DT.120999680 DT.120999634 DT.120999712 DT.40197218 DT.100666018 DT.100666021 DT.120999641 DT.92468625 DT.95156089 DT.95360603 DT.120999681 DT.95371550 DT.120753638 DT.120999663 24/1371 AceView cDNA sequences (see all 1371
):BI260020 BQ052439 BU184159 AA642182 CF619396 AI589519 BQ071712 AA630062 CB120525 BQ961911 BQ933371 AI334291 BQ775027 BM680530 BE740114 BU552525 AI635568 BQ956953 AI208452 L39924 AU136304 AI367115 BQ064555 BQ898771
 highest scoring ESTs for KPNB1:AA055083 AA055084 AA065122 AA075500 AA181580 AA191314 AA191315 AA251527 AA312918 AA564775 Unigene Clusters for KPNB1: Karyopherin (importin) beta 1 Hs.532793 [show with all ESTs], Hs.706168 [show with all ESTs]Unigene Representative Sequences: L38951, BG746254
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KPNB1 (see all 14
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KPNB1
1 Ensembl transcript including schematic representation: ENST00000290158
|
Expression
for KPNB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KPNB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KPNB1
1 / 2 / 3 9 probe-sets matching KPNB1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.532793 Hs.706168
Expression variation in blood from EXPOLDB for KPNB1 |
Orthologs
for KPNB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KPNB1 gene from 5/22 species (see all 22
)
About this table Species with no ortholog for KPNB1
ENSEMBL Gene Tree for KPNB1 | Paralogs
for KPNB1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KPNB1 gene
- TNPO22 TNPO12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants
for KPNB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KPNB1 (up to first 250kb)
|
Disorders & Mutations
for KPNB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602738
1 Novoseek disease relationship for KPNB1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0.00 |
2 |
19117056 (1) |
About this table
1 PharmGKB disease relationship for KPNB1 geneAbout this table
Human Genome Epidemiology Navigator: KPNB1 (1 document)
|
Medical News
for KPNB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KPNB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/151 PubMed articles for KPNB1 gene (see all 151
):- Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. (PubMed id 7627554)1, 2, 3, 4 Gorlich D....Prehn S. (1995)
- Sequence and characterization of cytoplasmic nuclear protein import factor p97. (PubMed id 7615630)2, 3, 4 Chi N.C.... Adam S.A. (1995)
- Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. (PubMed id 12504010)1, 3, 4 Cingolani G.... Gerace L. (2002)
- Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)3, 4 Arnold M.... Kehlenbach R.H. (2006)
- Regulation of human SRY subcellular distribution by its acetylation/deacetylation. (PubMed id 15297880)3, 4 Thevenet L....Boizet-Bonhoure B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Defective importin beta recognition and nuclear import of the sex- determining factor SRY are associated with XY sex-reversing mutations. (PubMed id 12764225)3, 4 Harley V.R.... Jans D.A. (2003)
- SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)3, 4 Narayanan U.... Matera A.G. (2002)
- Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. (PubMed id 10929717)3, 4 Bayliss R.... Stewart M. (2000)
- Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. (PubMed id 9891056)3, 4 Palmeri D. and Malim M.H. (1999)
|
Search for KPNB1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KPNB1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KPNB1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KPNB1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for KPNB1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for KPNB1:
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| | |  | Search Tocris compounds for KPNB1 |
|
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