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Aliases for KPNB1 Gene

Aliases for KPNB1 Gene

  • Karyopherin Subunit Beta 1 2 3
  • Karyopherin (Importin) Beta 1 2 3 5
  • Pore Targeting Complex 97 KDa Subunit 3 4
  • Karyopherin Subunit Beta-1 3 4
  • Nuclear Factor P97 3 4
  • Importin-90 3 4
  • Importin 1 2 3
  • PTAC97 3 4
  • NTF97 3 4
  • Importin Beta-1 Subunit 3
  • Importin 90 3
  • Impnb 3
  • IMB1 3
  • IPO1 3
  • IPOB 3

External Ids for KPNB1 Gene

Previous GeneCards Identifiers for KPNB1 Gene

  • GC17P045432
  • GC17P048207
  • GC17P046069
  • GC17P046201
  • GC17P043082
  • GC17P045727
  • GC17P041096

Summaries for KPNB1 Gene

Entrez Gene Summary for KPNB1 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KPNB1 Gene

KPNB1 (Karyopherin Subunit Beta 1) is a Protein Coding gene. Diseases associated with KPNB1 include Influenza and Hiv-1. Among its related pathways are Activation of DNA fragmentation factor and Infectious disease. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

UniProtKB/Swiss-Prot for KPNB1 Gene

  • Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Gene Wiki entry for KPNB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNB1 Gene

Genomics for KPNB1 Gene

Regulatory Elements for KPNB1 Gene

Enhancers for KPNB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KPNB1 on UCSC Golden Path with GeneCards custom track

Promoters for KPNB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KPNB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KPNB1 Gene

Chromosome:
17
Start:
47,649,476 bp from pter
End:
47,685,505 bp from pter
Size:
36,030 bases
Orientation:
Plus strand

Genomic View for KPNB1 Gene

Genes around KPNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNB1 Gene

Proteins for KPNB1 Gene

  • Protein details for KPNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14974-IMB1_HUMAN
    Recommended name:
    Importin subunit beta-1
    Protein Accession:
    Q14974
    Secondary Accessions:
    • B7ZAV6
    • D3DTT3
    • Q14637
    • Q53XN2
    • Q96J27

    Protein attributes for KPNB1 Gene

    Size:
    876 amino acids
    Molecular mass:
    97170 Da
    Quaternary structure:
    • Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory syncytial virus (HRSV) protein M. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity).

    Three dimensional structures from OCA and Proteopedia for KPNB1 Gene

    Alternative splice isoforms for KPNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KPNB1 Gene

Proteomics data for KPNB1 Gene at MOPED

Post-translational modifications for KPNB1 Gene

  • Mono-ADP-ribosylated by PARP16.
  • Ubiquitination at Lys 23, Lys 62, Lys 206, Lys 376, Lys 537, Lys 651, Lys 730, Lys 835, and Lys 859
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KPNB1 (Importin beta/KPNB1)
  • Cell Signaling Technology (CST) Antibodies for KPNB1 (KPNB1)

No data available for DME Specific Peptides for KPNB1 Gene

Domains & Families for KPNB1 Gene

Gene Families for KPNB1 Gene

Suggested Antigen Peptide Sequences for KPNB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14974

UniProtKB/Swiss-Prot:

IMB1_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family. Importin beta-1 subfamily.
  • Contains 19 HEAT repeats.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family. Importin beta-1 subfamily.
Similarity:
  • Contains 19 HEAT repeats.
genes like me logo Genes that share domains with KPNB1: view

Function for KPNB1 Gene

Molecular function for KPNB1 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Gene Ontology (GO) - Molecular Function for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with KPNB1: view
genes like me logo Genes that share phenotypes with KPNB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNB1 Gene

Localization for KPNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNB1 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNB1 Gene COMPARTMENTS Subcellular localization image for KPNB1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KPNB1: view

Pathways & Interactions for KPNB1 Gene

genes like me logo Genes that share pathways with KPNB1: view

SIGNOR curated interactions for KPNB1 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation TAS 7615630
GO:0006607 NLS-bearing protein import into nucleus TAS 7627554
GO:0006610 ribosomal protein import into nucleus IDA 9687515
GO:0006886 intracellular protein transport IEA --
GO:0007079 mitotic chromosome movement towards spindle pole IMP 23783028
genes like me logo Genes that share ontologies with KPNB1: view

Drugs & Compounds for KPNB1 Gene

(1) Drugs for KPNB1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for KPNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KPNB1: view

Transcripts for KPNB1 Gene

Unigene Clusters for KPNB1 Gene

Karyopherin (importin) beta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - - - - -
SP11:
SP12: - - - - - - - -
SP13: - -
SP14:

ExUns: 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KPNB1 Gene

GeneLoc Exon Structure for
KPNB1
ECgene alternative splicing isoforms for
KPNB1

Expression for KPNB1 Gene

mRNA expression in normal human tissues for KPNB1 Gene

Protein differential expression in normal tissues from HIPED for KPNB1 Gene

This gene is overexpressed in Bone (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNB1 Gene



SOURCE GeneReport for Unigene cluster for KPNB1 Gene Hs.532793

genes like me logo Genes that share expression patterns with KPNB1: view

Protein tissue co-expression partners for KPNB1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KPNB1 Gene

Orthologs for KPNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KPNB1 35
  • 95.28 (n)
  • 99.43 (a)
KPNB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNB1 35
  • 94.56 (n)
  • 99.43 (a)
KPNB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpnb1 35
  • 91.97 (n)
  • 99.2 (a)
Kpnb1 16
Kpnb1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KPNB1 35
  • 99.64 (n)
  • 100 (a)
KPNB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpnb1 35
  • 91.73 (n)
  • 98.63 (a)
oppossum
(Monodelphis domestica)
Mammalia KPNB1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNB1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves KPNB1 35
  • 82.87 (n)
  • 94.88 (a)
KPNB1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNB1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpnb1 35
  • 79.87 (n)
  • 95.09 (a)
Str.2859 35
zebrafish
(Danio rerio)
Actinopterygii kpnb1 35
  • 77.47 (n)
  • 92.01 (a)
kpnb1 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fs(2)Ket 37
  • 61 (a)
Fs(2)Ket 35
  • 59.3 (n)
  • 61.86 (a)
Fs(2)Ket 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009921 35
  • 60.77 (n)
  • 64.87 (a)
worm
(Caenorhabditis elegans)
Secernentea imb-1 37
  • 48 (a)
imb-1 35
  • 52.91 (n)
  • 48.97 (a)
imb-1 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL187W 35
  • 46.7 (n)
  • 36.28 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05665g 35
  • 48.32 (n)
  • 37.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP95 35
  • 47.2 (n)
  • 35.19 (a)
KAP95 36
  • 34 (a)
OneToOne
KAP95 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53480 35
  • 50.1 (n)
  • 40.73 (a)
rice
(Oryza sativa)
Liliopsida Os12g0568800 35
  • 50.94 (n)
  • 43.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20906 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02011 35
  • 49.46 (n)
  • 41.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap95 35
  • 50.06 (n)
  • 41.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6563 36
  • 61 (a)
OneToOne
Species with no ortholog for KPNB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KPNB1 Gene

ENSEMBL:
Gene Tree for KPNB1 (if available)
TreeFam:
Gene Tree for KPNB1 (if available)

Paralogs for KPNB1 Gene

Pseudogenes.org Pseudogenes for KPNB1 Gene

genes like me logo Genes that share paralogs with KPNB1: view

No data available for Paralogs for KPNB1 Gene

Variants for KPNB1 Gene

Sequence variations from dbSNP and Humsavar for KPNB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1136612 -- 47,656,868(+) TTGCA(A/C/G)ACATT reference, synonymous-codon, missense, utr-variant-5-prime
rs1136613 -- 47,658,609(+) GCTAC(A/G)AATGC reference, synonymous-codon
rs1136614 -- 47,673,102(+) TGTTA(C/T)CCTGC reference, synonymous-codon
rs1136638 -- 47,683,080(+) GCAGC(A/C)CAAGA utr-variant-3-prime
rs2277612 -- 47,650,192(+) CCGCC(C/T)GAAAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KPNB1 Gene

Variant ID Type Subtype PubMed ID
nsv525267 CNV Gain 19592680
dgv987e1 CNV Complex 17122850
nsv428344 CNV Gain 18775914
essv3532 CNV CNV 17122850

Variation tolerance for KPNB1 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KPNB1 Gene

Disorders for KPNB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KPNB1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search KPNB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KPNB1

Genetic Association Database (GAD)
KPNB1
Human Genome Epidemiology (HuGE) Navigator
KPNB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNB1
genes like me logo Genes that share disorders with KPNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNB1 Gene

Publications for KPNB1 Gene

  1. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. (PMID: 7627554) Goerlich D. … Prehn S. (Curr. Biol. 1995) 2 3 4 23 67
  2. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. (PMID: 19117056) van der Watt P.J. … Leaner V.D. (Int. J. Cancer 2009) 3 23
  3. Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. (PMID: 17596301) Frieman M. … Baric R.S. (J. Virol. 2007) 3 23
  4. A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. (PMID: 17646395) Fan S. … Margolis B. (J. Cell Biol. 2007) 3 23
  5. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. (PMID: 16552725) Lo H.W. … Hung M.C. (J. Cell. Biochem. 2006) 3 23

Products for KPNB1 Gene

Sources for KPNB1 Gene

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