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Aliases for KPNA7 Gene

Aliases for KPNA7 Gene

  • Karyopherin Subunit Alpha 7 2 3
  • Karyopherin Alpha 7 (Importin Alpha 8) 2 3 5
  • Karyopherin Subunit Alpha-7 3 4
  • Importin Alpha 8 2 3
  • Karyopherin Alpha 7 2
  • Karyopherin 7 3
  • IPOA8 3

External Ids for KPNA7 Gene

Previous GeneCards Identifiers for KPNA7 Gene

  • GC07M098614
  • GC07M098771
  • GC07M093403

Summaries for KPNA7 Gene

GeneCards Summary for KPNA7 Gene

KPNA7 (Karyopherin Subunit Alpha 7) is a Protein Coding gene. Diseases associated with KPNA7 include partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome and lennox-gastaut syndrome. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA7 Gene

  • Functions in nuclear protein import.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA7 Gene

Genomics for KPNA7 Gene

Regulatory Elements for KPNA7 Gene

Genomic Location for KPNA7 Gene

Chromosome:
7
Start:
99,173,574 bp from pter
End:
99,219,333 bp from pter
Size:
45,760 bases
Orientation:
Minus strand

Genomic View for KPNA7 Gene

Genes around KPNA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA7 Gene

Proteins for KPNA7 Gene

  • Protein details for KPNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9QM74-IMA8_HUMAN
    Recommended name:
    Importin subunit alpha-8
    Protein Accession:
    A9QM74
    Secondary Accessions:
    • A4D277

    Protein attributes for KPNA7 Gene

    Size:
    516 amino acids
    Molecular mass:
    56938 Da
    Quaternary structure:
    • Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs.
    SequenceCaution:
    • Sequence=EAL23884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KPNA7 Gene

Proteomics data for KPNA7 Gene at MOPED

Post-translational modifications for KPNA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPNA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KPNA7 Gene

Domains & Families for KPNA7 Gene

Gene Families for KPNA7 Gene

Protein Domains for KPNA7 Gene

Suggested Antigen Peptide Sequences for KPNA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A9QM74

UniProtKB/Swiss-Prot:

IMA8_HUMAN :
  • Contains 1 IBB domain.
  • Belongs to the importin alpha family.
  • Contains 8 ARM repeats.
Domain:
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 8 ARM repeats.
genes like me logo Genes that share domains with KPNA7: view

Function for KPNA7 Gene

Molecular function for KPNA7 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import.

Gene Ontology (GO) - Molecular Function for KPNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with KPNA7: view

Phenotypes for KPNA7 Gene

GenomeRNAi human phenotypes for KPNA7:
genes like me logo Genes that share phenotypes with KPNA7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KPNA7 Gene

Localization for KPNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA7 Gene COMPARTMENTS Subcellular localization image for KPNA7 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KPNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KPNA7: view

Pathways & Interactions for KPNA7 Gene

genes like me logo Genes that share pathways with KPNA7: view

Gene Ontology (GO) - Biological Process for KPNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019054 modulation by virus of host process TAS --
GO:0075733 intracellular transport of virus TAS --
genes like me logo Genes that share ontologies with KPNA7: view

No data available for SIGNOR curated interactions for KPNA7 Gene

Drugs & Compounds for KPNA7 Gene

No Compound Related Data Available

Transcripts for KPNA7 Gene

mRNA/cDNA for KPNA7 Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KPNA7 Gene

Karyopherin alpha 7 (importin alpha 8):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA7 Gene

No ASD Table

Relevant External Links for KPNA7 Gene

GeneLoc Exon Structure for
KPNA7
ECgene alternative splicing isoforms for
KPNA7

Expression for KPNA7 Gene

mRNA expression in normal human tissues for KPNA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA7 Gene

This gene is overexpressed in Stomach (x9.7), Esophagus - Mucosa (x9.3), and Ovary (x5.1).

SOURCE GeneReport for Unigene cluster for KPNA7 Gene Hs.253050

genes like me logo Genes that share expression patterns with KPNA7: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KPNA7 Gene

Orthologs for KPNA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for KPNA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KPNA7 35
  • 79.29 (n)
  • 76.73 (a)
KPNA7 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA7 35
  • 83.76 (n)
  • 82.05 (a)
KPNA7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna7 35
  • 72.34 (n)
  • 63.32 (a)
Kpna7 16
Kpna7 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KPNA7 35
  • 99.03 (n)
  • 98.84 (a)
KPNA7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna7 35
  • 74.42 (n)
  • 66.33 (a)
oppossum
(Monodelphis domestica)
Mammalia KPNA7 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA7 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves KPNA7 35
  • 65.29 (n)
  • 61.54 (a)
KPNA7 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA7 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna7 35
  • 62.24 (n)
  • 61.39 (a)
zebrafish
(Danio rerio)
Actinopterygii kpna7 35
  • 57.91 (n)
  • 52.77 (a)
kpna7 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ima-2 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for KPNA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA7 Gene

ENSEMBL:
Gene Tree for KPNA7 (if available)
TreeFam:
Gene Tree for KPNA7 (if available)

Paralogs for KPNA7 Gene

Paralogs for KPNA7 Gene

(6) SIMAP similar genes for KPNA7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KPNA7 Gene

genes like me logo Genes that share paralogs with KPNA7: view

Variants for KPNA7 Gene

Sequence variations from dbSNP and Humsavar for KPNA7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1343834 -- 99,203,373(+) CACAG(G/T)TAGTA intron-variant, upstream-variant-2KB
rs1880784 -- 99,190,090(-) aagtg(C/T)tgggg intron-variant
rs1880785 -- 99,196,488(-) TGCCT(A/C/G)TGTGG intron-variant
rs2395020 -- 99,210,216(+) GTACT(C/T)GGGCC intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs4341098 -- 99,216,813(+) CGCCT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA7 Gene

Variant ID Type Subtype PubMed ID
dgv828n27 CNV Loss 19166990
nsv509216 CNV Insertion 20534489
esv2734876 CNV Deletion 23290073
esv2734877 CNV Deletion 23290073
esv2734878 CNV Deletion 23290073
esv2734879 CNV Deletion 23290073
esv2623610 CNV Deletion 19546169
esv2734880 CNV Deletion 23290073
esv2734881 CNV Deletion 23290073
esv2660936 CNV Deletion 23128226

Variation tolerance for KPNA7 Gene

Gene Damage Index Score: 2.47; 43.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA7 Gene

HapMap Linkage Disequilibrium report
KPNA7
Human Gene Mutation Database (HGMD)
KPNA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA7 Gene

Disorders for KPNA7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KPNA7 Gene - From: Orphanet and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search KPNA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KPNA7

Genetic Association Database (GAD)
KPNA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA7
genes like me logo Genes that share disorders with KPNA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA7 Gene

Publications for KPNA7 Gene

  1. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3 48 67
  2. Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. (PMID: 24045845) Paciorkowski A.R. … Paschal B.M. (Eur. J. Hum. Genet. 2014) 3
  3. [Identification of prototype foamy virus Bel1 nuclear localization signal and its corresponding importins]. (PMID: 25272585) Ma Q.L. … Qiao W.T. (Bing Du Xue Bao 2014) 3
  4. KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro. (PMID: 24275456) Laurila E. … Kallioniemi A. (Exp. Cell Res. 2013) 3
  5. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. (PMID: 20701745) Kelley J.B. … Paschal B.M. (BMC Cell Biol. 2010) 3

Products for KPNA7 Gene

Sources for KPNA7 Gene

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