Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KPNA7 Gene

protein-coding GIFtS: 43
GCID: GC07M098771

karyopherin alpha 7 (importin alpha 8)

Explore 2 diseases affiliated with
KPNA7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Karyopherin Alpha 7 (Importin Alpha 8)¹ ²
Karyopherin Subunit Alpha-7² ³
Importin Subunit Alpha-8²
Karyopherin 7²

External Ids:	HGNC: 21839¹	Entrez Gene: 402569²	Ensembl: ENSG00000185467⁷	OMIM: 614107⁵	UniProtKB: A9QM74³

Export aliases for KPNA7 gene to outside databases

Previous GC identifers: GC07M098614 GC07M093403

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IMA8_HUMAN, A9QM74

Function: Functions in nuclear protein import (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KPNA7 gene promoter:
AhR SRF POU2F1 SRF (504 AA) POU2F1a Arnt
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KPNA7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1

KPNA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M098771: view genomic region (about GC identifiers)

Start:	98,771,197 bp from pter	End:	98,805,129 bp from pter
Size:	33,933 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,127,179-98,161,076

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IMA8_HUMAN, A9QM74 (See protein sequence)

Recommended Name: Importin subunit alpha-8

Size: 516 amino acids; 56938 Da

Subunit: Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the

presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor

NPM1 NLSs

Subcellular location: Nucleus

Sequence caution: Sequence=EAL23884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A4D277

Explore the universe of human proteins at neXtProt for KPNA7: NX_A9QM74

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A9QM74

KPNA7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001139187.1

ENSEMBL proteins:

ENSP00000330878

Reactome Protein details: A9QM74
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KPNA7 OriGene Custom Protein Services for KPNA7
	GenScript Custom Purified and Recombinant Proteins Services for KPNA7
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--

KPNA7 for ontologies About GeneDecksing

KPNA7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KPNA7
	GenScript Custom Superior Antibodies Services for KPNA7
	Novus Biologicals KPNA7 Antibody
	Search for Antibodies for KPNA7 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for KPNA7

Assay Products for KPNA7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KPNA7
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KPNA7 for domains About GeneDecksing

5 InterPro domains/families:

IPR011989 ARM-like

IPR000225 Armadillo

IPR024931 Importing_su_alpha

IPR002652 Importin-a_IBB

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry A9QM74

ProtoNet protein and cluster: A9QM74

UniProtKB/Swiss-Prot: IMA8_HUMAN, A9QM74

Similarity: Belongs to the importin alpha family

Similarity: Contains 8 ARM repeats

Similarity: Contains 1 IBB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IMA8_HUMAN, A9QM74

Function: Functions in nuclear protein import (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA7
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KPNA7
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA7 (see all 4) OriGene shRNA RFP: KPNA7 OriGene siRNA: KPNA7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KPNA7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KPNA7 (NM_001145715)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA7
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KPNA7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KPNA7
		Search LifeMap BioReagents cell lines for KPNA7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA7

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008565	protein transporter activity	IEA	--

KPNA7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KPNA7:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00			ISG15 antiviral mechanism	0.49
	Antiviral mechanism by IFN-stimulated genes	0.49

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for KPNA7 (see all 6)

	Antiviral mechanism by IFN-stimulated genes
	Cytokine Signaling in Immune system
	Interferon Signaling
	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
	ISG15 antiviral mechanism

KPNA7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KPNA7

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for KPNA7 (A9QM74³ ENSP00000330878⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H1C	P16403³, ENSP00000339566⁴	I2D: score=1 STRING: ENSP00000339566
SPOP	ENSP00000240327⁴	STRING: ENSP00000240327
RAC1	ENSP00000348461⁴	STRING: ENSP00000348461
CSE1L	ENSP00000262982⁴	STRING: ENSP00000262982

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006606	protein import into nucleus	IEA	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--

KPNA7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KPNA7
Search CenterWatch for drugs/clinical trials and news about KPNA7 / IMA8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KPNA7 gene:

NM_001145715.1

Unigene Cluster for KPNA7:

Karyopherin alpha 7 (importin alpha 8)

Hs.253050 [show with all ESTs]

Unigene Representative Sequence: NM_001145715

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000327442(uc010lft.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA7
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KPNA7
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA7 (see all 4) OriGene shRNA RFP: KPNA7 OriGene siRNA: KPNA7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KPNA7 (NM_001145715)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA7
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KPNA7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KPNA7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA7

Additional cDNA sequence: EU126604.1

2 DOTS entries:

DT.102820269 DT.121125735

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KPNA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCAGCTGA

About this image

KPNA7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KPNA7 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.253050

SABiosciences Custom PCR Arrays for KPNA7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KPNA7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA7 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KPNA7¹	karyopherin alpha 7 (importin alpha 8)	65.29(n) 61.54(a)		416488 XM_414795.3 XP_414795.3
lizard (Anolis carolinensis)	Reptilia	KPNA7⁶	--	48(a)	1 ↔ 1	3(18178330-18179312)
zebrafish (Danio rerio)	Actinopterygii	zgc:55877¹	zgc:55877	57.77(n) 52.77(a)		406343 NM_213070.1 NP_998235.1
fruit fly (Drosophila melanogaster)	Insecta	Pen⁶	Pendulin	43(a)	1 → many	2L(10056906-10060095)
worm (Caenorhabditis elegans)	Secernentea	ima-2⁶	Importin subunit alpha-2	31(a)	1 → many	I(6315233-6317269)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G32880⁶	armadillo/beta-catenin-like repeats-containing pro...	32(a)	1 → many	1(11913928-11914735)

ENSEMBL Gene Tree for KPNA7 (if available)
TreeFam Gene Tree for KPNA7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KPNA7 gene

KPNA3² SPAG6² KPNA5² KPNA2² KPNA4² KPNA1² KPNA6²

6 SIMAP similar genes for KPNA7 using alignment to 1 protein entry: IMA8_HUMAN:

KPNA2 KPNA4 KPNA3 KPNA5 KPNA1 KPNA6

KPNA7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KPNA7
PGOHUM00000235279

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200805277^1,2		--	98770702(+)	`AAAAA-/GAAAAA`	1	--	int¹		0	--	--	--	--
rs191345374^1,2		--	98770703(+)	`AAAAAA/GAAAAG`	1	--	int¹		0	--	--	--	--
rs200666211^1,2		--	98770703(+)	`AAAAA-/GAAAAG`	1	--	int¹		0	--	--	--	--
rs183883066^1,2		--	98770704(+)	`AAAAAA/GAAAGA`	1	--	int¹		0	--	--	--	--
rs186944689^1,2		--	98770728(+)	`TGTCCA/GGATAA`	1	--	int¹		0	--	--	--	--
rs191845606^1,2		--	98770794(+)	`CAATTA/GCTAAA`	1	--	int¹		0	--	--	--	--
rs185269002^1,2		--	98770873(+)	`CAATGA/GCTCCA`	1	--	int¹		0	--	--	--	--
rs189999135^1,2		--	98771004(+)	`AGAGAC/TGGAGT`	1	--	int¹		0	--	--	--	--
rs144762282^1,2		--	98771021(+)	`GTGTTA/GGCCAG`	1	--	int¹		0	--	--	--	--
rs115667667^1,2	C,F,	--	98771194(+)	`GAAACG/ATGAAA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for KPNA7 (98771197 - 98805129 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KPNA7
1 CNV: 53523
1 Indel: 100050

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA7

DNA2.0 Custom Variant and Variant Library Synthesis for KPNA7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KPNA7 for disorders           About GeneDecksing

OMIM gene information: 614107    OMIM disorders: --

2 diseases for KPNA7:    About MalaCards

ulcerative colitis malaria

Export disorders for KPNA7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KPNA7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KPNA7)

Utopia: connect your pdf to the dynamic
world of online information

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. (PubMed id 20701745)^{1, 2} Kelley J.B....Paschal B.M. (2010)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)¹ Franke A....Vatn M.H. (2010)
Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription. (PubMed id 18258596)¹ Kim K....An W. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 402569	HGNC: 21839	Ensembl:ENSG00000185467	euGenes: HUgn402569	ECgene: KPNA7
H-InvDB: KPNA7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KPNA7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KPNA7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KPNA7 gene:
Search GeneIP for patents involving KPNA7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KPNA7
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA7
	OriGene Protein Over-expression Lysate for KPNA7		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KPNA7		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KPNA7		OriGene Custom Protein Services for KPNA7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPNA7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA7

	GenScript Custom Purified and Recombinant Proteins Services for KPNA7		GenScript cDNA clones with any tag delivered in your preferred vector for KPNA7
	GenScript Custom Assay Services for KPNA7		GenScript Custom Superior Antibodies Services for KPNA7
	GenScript Custom overexpressing Cell Line Services for KPNA7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KPNA7 promoter
	Search Chromatin IP Primers for KPNA7
	RT² qPCR Primer Assay in human, mouse, rat KPNA7
	Search GNC Networks for KPNA7
	SABiosciences Custom PCR Arrays for KPNA7

Search Tocris compounds for KPNA7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KPNA7 antibodies

	Search for Antibodies for KPNA7 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KPNA7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for KPNA7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA7

	Browse SwitchGear 3'UTR luciferase reporter plasmids for KPNA7
	Browse SwitchGear Promoter luciferase reporter plasmids for KPNA7

Search ThermoFisher Antibodies for KPNA7

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KPNA7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KPNA7 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KPNA7 Gene

karyopherin alpha 7 (importin alpha 8)

Aliases
for KPNA7 gene

Summaries
for KPNA7 gene

Genomic Views
for KPNA7 gene

Proteins
for KPNA7 gene

Protein Domains /
Families
for KPNA7 gene

Function
for KPNA7 gene

Pathways & Interactions
for KPNA7 gene

Drugs & Compounds
for KPNA7 gene

Transcripts
for KPNA7 gene

Expression
for KPNA7 gene

Orthologs
for KPNA7 gene

Paralogs
for KPNA7 gene

Genomic Variants
for KPNA7 gene

Disorders / Diseases
for KPNA7 gene

Publications
for KPNA7 gene

External Searches for KPNA7 gene

Genome Databases showing KPNA7 gene

Other Databases showing KPNA7 gene

Specialized Databases showing KPNA7 gene

Intellectual Property
for KPNA7 gene

Products
for KPNA7 gene

View Random Gene

Advanced Search

Export list of displayed genes

KPNA7 Gene

karyopherin alpha 7 (importin alpha 8)

Aliasesfor KPNA7 gene

Summariesfor KPNA7 gene

Genomic Viewsfor KPNA7 gene

Proteinsfor KPNA7 gene

Protein Domains /Familiesfor KPNA7 gene

Functionfor KPNA7 gene

Pathways & Interactionsfor KPNA7 gene

Drugs & Compoundsfor KPNA7 gene

Transcriptsfor KPNA7 gene

Expression for KPNA7 gene

Orthologsfor KPNA7 gene

Paralogsfor KPNA7 gene

Genomic Variantsfor KPNA7 gene

Disorders / Diseasesfor KPNA7 gene

Publicationsfor KPNA7 gene

External Searches for KPNA7 gene

Genome Databases showing KPNA7 gene

Other Databases showing KPNA7 gene

Specialized Databases showing KPNA7 gene

Intellectual Propertyfor KPNA7 gene

Productsfor KPNA7 gene

View Random Gene

Aliases
for KPNA7 gene

Summaries
for KPNA7 gene

Genomic Views
for KPNA7 gene

Proteins
for KPNA7 gene

Protein Domains /
Families
for KPNA7 gene

Function
for KPNA7 gene

Pathways & Interactions
for KPNA7 gene

Drugs & Compounds
for KPNA7 gene

Transcripts
for KPNA7 gene

Expression
for KPNA7 gene

Orthologs
for KPNA7 gene

Paralogs
for KPNA7 gene

Genomic Variants
for KPNA7 gene

Disorders / Diseases
for KPNA7 gene

Publications
for KPNA7 gene

Intellectual Property
for KPNA7 gene

Products
for KPNA7 gene