Aliases for KPNA7 Gene
External Ids for KPNA7 Gene
Previous GeneCards Identifiers for KPNA7 Gene
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]
GeneCards Summary for KPNA7 Gene
KPNA7 (Karyopherin Subunit Alpha 7) is a Protein Coding gene. Diseases associated with KPNA7 include Partial Corpus Callosum Agenesis-Cerebellar Vermis Hypoplasia With Posterior Fossa Cysts Syndrome and Lennox-Gastaut Syndrome. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA2.
UniProtKB/Swiss-Prot for KPNA7 Gene
Functions in nuclear protein import.