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Aliases for KPNA6 Gene

Aliases for KPNA6 Gene

  • Karyopherin Alpha 6 (Importin Alpha 7) 2 3
  • Karyopherin Subunit Alpha-6 3 4
  • IPOA7 3 4
  • Importin Alpha 7 Subunit 3
  • Importin Subunit Alpha-7 3
  • Importin-Alpha-S2 3
  • KPNA7 3

External Ids for KPNA6 Gene

Summaries for KPNA6 Gene

Entrez Gene Summary for KPNA6 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA6 Gene

KPNA6 (Karyopherin Alpha 6 (Importin Alpha 7)) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA6 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for KPNA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA6 Gene

Genomics for KPNA6 Gene

Genomic Location for KPNA6 Gene

Start:
32,108,038 bp from pter
End:
32,176,568 bp from pter
Size:
68,531 bases
Orientation:
Plus strand

Genomic View for KPNA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA6 Gene

Regulatory Elements for KPNA6 Gene

Proteins for KPNA6 Gene

  • Protein details for KPNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60684-IMA7_HUMAN
    Recommended name:
    Importin subunit alpha-7
    Protein Accession:
    O60684
    Secondary Accessions:
    • B2RDC7
    • D3DPP5
    • Q5VVU3

    Protein attributes for KPNA6 Gene

    Size:
    536 amino acids
    Molecular mass:
    60030 Da
    Quaternary structure:
    • Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1.

    Three dimensional structures from OCA and Proteopedia for KPNA6 Gene

neXtProt entry for KPNA6 Gene

Proteomics data for KPNA6 Gene at MOPED

Post-translational modifications for KPNA6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys49, Lys134, Lys354, and Lys396

Other Protein References for KPNA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KPNA6 Gene

Domains for KPNA6 Gene

Gene Families for KPNA6 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • IPO :Importins

UniProtKB/Swiss-Prot:

IMA7_HUMAN
Domain:
  • Contains 1 IBB domain.:
    • O60684
Family:
  • Belongs to the importin alpha family.:
    • O60684
Similarity:
  • Contains 10 ARM repeats.:
    • O60684
genes like me logo Genes that share domains with KPNA6: view

Function for KPNA6 Gene

Molecular function for KPNA6 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with KPNA6: view

Phenotypes for KPNA6 Gene

genes like me logo Genes that share phenotypes with KPNA6: view

Animal Models for KPNA6 Gene

MGI Knock Outs for KPNA6:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KPNA6 Gene

Localization for KPNA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA6 Gene COMPARTMENTS Subcellular localization image for KPNA6 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KPNA6: view

Pathways for KPNA6 Gene

genes like me logo Genes that share pathways with KPNA6: view

Pathways by source for KPNA6 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KPNA6 Gene
1 BioSystems pathway for KPNA6 Gene

Gene Ontology (GO) - Biological Process for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0060135 maternal process involved in female pregnancy IEA --
genes like me logo Genes that share ontologies with KPNA6: view

Compounds for KPNA6 Gene

(1) HMDB Compounds for KPNA6 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KPNA6: view

Transcripts for KPNA6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for KPNA6 Gene

GeneLoc Exon Structure for
KPNA6
ECgene alternative splicing isoforms for
KPNA6

Expression for KPNA6 Gene

mRNA expression in normal human tissues for KPNA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KPNA6 Gene

SOURCE GeneReport for Unigene cluster for KPNA6 Gene Hs.470588

mRNA Expression by UniProt/SwissProt for KPNA6 Gene

O60684-IMA7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with KPNA6: view

Orthologs for KPNA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA6 36
  • 99.88 (n)
  • 100 (a)
KPNA6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA6 36
  • 94.9 (n)
  • 99.25 (a)
KPNA6 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA6 36
  • 94.64 (n)
  • 99.81 (a)
KPNA6 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna6 36
  • 91.79 (n)
  • 99.25 (a)
Kpna6 16
Kpna6 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA6 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kpna6 36
  • 92.52 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves KPNA6 36
  • 80.62 (n)
  • 94.58 (a)
KPNA6 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA6 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna6 36
  • 76.49 (n)
  • 90.43 (a)
zebrafish
(Danio rerio)
Actinopterygii KPNA6 37
  • 89 (a)
OneToOne
LOC100149852 36
  • 75.87 (n)
  • 88.81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005401 36
  • 61.38 (n)
  • 65.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 36
  • 60.65 (n)
  • 65.24 (a)
Kap-alpha1 37
  • 62 (a)
OneToMany
Kap-alpha1 38
  • 62 (a)
Pen 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 37
  • 51 (a)
OneToMany
SRP1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons IMPA-2 36
  • 57.54 (n)
  • 57.47 (a)
rice
(Oryza sativa)
Liliopsida Os01g0253300 36
  • 58.86 (n)
  • 58.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes imp1 36
  • 55.67 (n)
  • 57.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToMany
Species with no ortholog for KPNA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA6 Gene

ENSEMBL:
Gene Tree for KPNA6 (if available)
TreeFam:
Gene Tree for KPNA6 (if available)

Paralogs for KPNA6 Gene

Paralogs for KPNA6 Gene

Selected SIMAP similar genes for KPNA6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KPNA6: view

Variants for KPNA6 Gene

Sequence variations from dbSNP and Humsavar for KPNA6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10415 -- 32,172,923(-) TCAAT(A/G)GCCAA utr-variant-3-prime
rs14101 -- 32,172,963(-) TGAAG(C/T)GGGAC utr-variant-3-prime
rs485689 -- 32,130,859(+) CTAAT(G/T)GCTat intron-variant
rs488382 -- 32,120,313(+) gattt(G/T)ggctc intron-variant
rs494291 -- 32,117,626(+) CTCAA(A/G)ACAAA intron-variant

Relevant External Links for KPNA6 Gene

HapMap Linkage Disequilibrium report
KPNA6

No data available for Structural Variations from Database of Genomic Variants (DGV) for KPNA6 Gene

Disorders for KPNA6 Gene

No disorders were found for KPNA6 Gene.

No data available for UniProtKB/Swiss-Prot for KPNA6 Gene

Publications for KPNA6 Gene

  1. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (PMID: 10523667) Koehler M. … Hartmann E. (Mol. Cell. Biol. 1999) 2 3 4 23
  2. Acetylation of importin-alpha nuclear import factors by CBP/p300. (PMID: 10801418) Bannister A.J. … Kouzarides T. (Curr. Biol. 2000) 3 23
  3. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. (PMID: 16298512) Ma J. … Cao X. (Cell. Signal. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for KPNA6 Gene

  • Addgene plasmids for KPNA6

Sources for KPNA6 Gene

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