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KPNA6 Gene

protein-coding   GIFtS: 58
GCID: GC01P032573

Karyopherin Alpha 6 (Importin Alpha 7)

  Search for KPNA6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Karyopherin Alpha 6 (Importin Alpha 7)1 2     Importin Alpha 7 Subunit2
Karyopherin Subunit Alpha-62 3     Importin Subunit Alpha-72
IPOA72 3     importin-alpha-S22
KPNA72     

External Ids:    HGNC: 63991   Entrez Gene: 236332   Ensembl: ENSG000000258007   OMIM: 6105635   UniProtKB: O606843   

Export aliases for KPNA6 gene to outside databases

Previous GC identifers: GC01P032388 GC01P031561 GC01P032000 GC01P032076 GC01P032242 GC01P032346 GC01P030689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KPNA6 Gene:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes
embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires
the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin
alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side
of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran,
the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the
nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is
a member of the importin alpha family. (provided by RefSeq, Jul 2008)

GeneCards Summary for KPNA6 Gene:
KPNA6 (karyopherin alpha 6 (importin alpha 7)) is a protein-coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA7_HUMAN, O60684
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus

Gene Wiki entry for KPNA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KPNA6 gene promoter:
         SRF   RFX1   NF-1   SRF (504 AA)   MIF-1   MEF-2A   Egr-2   HOXA5   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA6 promoter sequence
   Search Chromatin IP Primers for KPNA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KPNA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

KPNA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032573:  view genomic region     (about GC identifiers)

Start:
32,573,639 bp from pter      End:
32,642,169 bp from pter
Size:
68,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMA7_HUMAN, O60684 (See protein sequence)
Recommended Name: Importin subunit alpha-7  
Size: 536 amino acids; 60030 Da
Subunit: Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1
Secondary accessions: B2RDC7 D3DPP5 Q5VVU3

Explore the universe of human proteins at neXtProt for KPNA6: NX_O60684

Explore proteomics data for KPNA6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys49, Lys134, Lys354, Lys396
  • Modification sites at PhosphoSitePlus

  • See KPNA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036448.1  
    ENSEMBL proteins: 
     ENSP00000362728   ENSP00000474234   ENSP00000415677   ENSP00000440609   ENSP00000444930  

    KPNA6 Human Recombinant Protein Products:

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    Novus Biologicals KPNA6 Proteins
    Novus Biologicals KPNA6 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KPNA6 

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    Search eBioscience for ELISAs for KPNA6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O60684

    ProtoNet protein and cluster: O60684

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA7_HUMAN, O60684
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Find genes that share domains with KPNA6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA7_HUMAN, O60684
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with KPNA6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kpna6):
     other  reproductive system 

    Find genes that share phenotypes with KPNA6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kpna6tm1Bdr for KPNA6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KPNA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KPNA6

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    miRNA
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    miRTarBase miRNAs that target KPNA6:
    hsa-mir-615-3p (MIRT040104), hsa-let-7a-5p (MIRT052621), hsa-mir-222-3p (MIRT046703), hsa-mir-877-3p (MIRT036872), hsa-let-7b-5p (MIRT052349), hsa-mir-378a-3p (MIRT043939), hsa-mir-98-5p (MIRT027429), hsa-mir-92a-3p (MIRT049058), hsa-mir-221-3p (MIRT046883), hsa-mir-24-3p (MIRT030446)

    Block miRNA regulation of human, mouse, rat KPNA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KPNA6 (see all 187):
    hsa-miR-3938 hsa-miR-640 hsa-miR-1321 hsa-miR-146a hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat KPNA6

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    GenScript: all cDNA clones in your preferred vector: KPNA6 (NM_012316)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA6
    Addgene plasmids for KPNA6 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with KPNA6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KPNA6 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KPNA6
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA6
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KPNA6
    Interactions:

        Search GeneGlobe Interaction Network for KPNA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KPNA6 (O606842, 3 ENSP000003627284) via UniProtKB, MINT, STRING, and/or I2D (see all 304)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing protein import into nucleus TAS9395085
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0060135maternal process involved in female pregnancy IEA--

    Find genes that share ontologies with KPNA6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KPNA6 (IMA7)

    1 HMDB Compound for KPNA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KPNA6 gene: 
    NM_012316.4  

    Unigene Cluster for KPNA6:

    Karyopherin alpha 6 (importin alpha 7)
    Hs.470588  [show with all ESTs]
    Unigene Representative Sequence: NM_012316
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373625(uc001bug.3 uc001buh.3 uc010ogx.2 uc010ogy.2)
    ENST00000471599 ENST00000469790 ENST00000446515 ENST00000545542 ENST00000537234

    miRNA
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    Block miRNA regulation of human, mouse, rat KPNA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KPNA6 (see all 187):
    hsa-miR-3938 hsa-miR-640 hsa-miR-1321 hsa-miR-146a hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KPNA6
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA6
    Addgene plasmids for KPNA6 
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      QuantiTect SYBR Green Assays in human, mouse, rat KPNA6
      QuantiFast Probe-based Assays in human, mouse, rat KPNA6

    Additional mRNA sequence: 

    AB621806.1 AF060543.1 AK002111.1 AK128609.1 AK295615.1 AK301714.1 AK315490.1 BC020520.1 
    BT009843.1 

    21 DOTS entries:

    DT.95265986  DT.413991  DT.100812266  DT.101960555  DT.100777992  DT.95363854  DT.95124203  DT.97846825 
    DT.100686859  DT.100805004  DT.121341539  DT.121341548  DT.121341609  DT.91755387  DT.95190126  DT.121341583 
    DT.40106976  DT.86852720  DT.91755385  DT.95168647  DT.95168649 

    Selected AceView cDNA sequences (see all 333):

    BU556926 AA724529 AW292559 BU739026 CA390785 AI673778 BU163476 BM676596 
    AA736523 BP348439 AA642174 AA009595 CN481403 AI799686 AU132876 BC020520 
    AI066714 CD370222 BU618021 BM765891 BQ720542 AI623423 AW006715 BU608322 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -                       -                             -                                 
    SP2:                          -     -                       -                             -                                 
    SP3:                                -                                                                                       
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for KPNA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KPNA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTGAGTG
    KPNA6 Expression
    About this image


    KPNA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    KPNA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KPNA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470588

    UniProtKB/Swiss-Prot: IMA7_HUMAN, O60684
    Tissue specificity: Widely expressed

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    QuantiFast Probe-based Assays in human, mouse, rat KPNA6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA6 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kpna61 , 5 karyopherin (importin) alpha 61, 5 91.79(n)1
    99.25(a)1
      4 (63.28 cM)5
    166501  NM_008468.41  NP_032494.31 
     1296439805 
    chicken
    (Gallus gallus)
    Aves KPNA61 karyopherin alpha 6 (importin alpha 7) 80.62(n)
    94.58(a)
      419656  NM_001012841.2  NP_001012859.2 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA66
    karyopherin alpha 6 (importin alpha 7)
    91(a)
    1 ↔ 1
    GL343706.1(179343-200895)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ618206.12   -- 76.8(n)    BJ618206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498521 importin subunit alpha-7-like 75.87(n)
    88.81(a)
      100149852  XM_001923886.3  XP_001923921.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha11 , 3 protein-nucleus import protein carrier3
    karyopherin alpha11
    62(a)
    (best of 2)3
    60.65(n)1
    65.24(a)1
      76C63
    401601  NM_079443.21  NP_524167.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP1(YNL189W)4 Karyopherin alpha homolog, forms a dimer with karyopherin more   --   14(284260-285888) 855532  NP_014210.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IMPA-21 IMPA-2 57.54(n)
    57.47(a)
      827302  NM_117708.5  NP_567485.4 
    rice
    (Oryza sativa)
    Liliopsida AB024311.12   -- 77.02(n)    AB024311.1 


    ENSEMBL Gene Tree for KPNA6 (if available)
    TreeFam Gene Tree for KPNA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KPNA6 gene
    KPNA72  KPNA32  SPAG62  KPNA52  KPNA22  KPNA42  KPNA12  
    6 SIMAP similar genes for KPNA6 using alignment to 7 protein entries:     IMA7_HUMAN (see all proteins):
    KPNA5    KPNA1    KPNA3    KPNA4    KPNA2    KPNA7

    Find genes that share paralogs with KPNA6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KPNA6 (see all 1328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407646291,2
    C--30687956(+) AGCAGA/GGGCAG 1 -- us2k10--------
    rs120922661,2
    C,H--30688005(+) TCCTAG/AAGTTT 1 -- us2k16Minor allele frequency- A:0.00NS EA NA 418
    rs1446117581,2
    --30688049(+) CAGGCA/GCACAA 1 -- us2k10--------
    rs1842945071,2
    --32571696(+) AGAAGA/GTAGAT 1 -- us2k10--------
    rs1887229211,2
    --32571791(+) CTGATA/GTGTAC 1 -- us2k10--------
    rs1149626571,2
    F--32571810(+) CGTCCC/TGTGAT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs115778101,2
    C,F,A,H--32571986(+) agataC/Tggtgg 1 -- us2k18Minor allele frequency- T:0.01NS EA NA 544
    rs1811066841,2
    --32572065(+) TCACTC/TTGTTA 1 -- us2k10--------
    rs1479600551,2
    --32572079(+) ATACTA/GCATGG 1 -- us2k10--------
    rs1158444161,2
    F--32572086(+) ATGGGT/GCTCAT 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for KPNA6 (32573639 - 32642169 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KPNA6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA6
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610563    OMIM disorders: --


    Find genes that share disorders with KPNA6           About GenesLikeMe


    Export disorders for KPNA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KPNA6 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with KPNA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (PubMed id 10523667)1, 2, 3, 9 Koehler M.... Hartmann E. (Mol. Cell. Biol. 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. (PubMed id 16298512)1, 9 Ma J. and Cao X. (Cell. Signal. 2006)
    5. Acetylation of importin-alpha nuclear import factors by CBP/p300. (PubMed id 10801418)1, 9 Bannister A.J....Kouzarides T. (Curr. Biol. 2000)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Cellular cofactors of lentiviral integrase: from target validation to drug discovery. (PubMed id 22928108)1 Taltynov O....Debyser Z. (Mol Biol Int 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23633 HGNC: 6399 AceView: KPNA6 Ensembl:ENSG00000025800 euGenes: HUgn23633
    ECgene: KPNA6 H-InvDB: KPNA6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KPNA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KPNA6 gene:
    Search GeneIP for patents involving KPNA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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