Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KPNA5 Gene

protein-coding   GIFtS: 60
GCID: GC06P117048

Karyopherin Alpha 5 (Importin Alpha 6)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Karyopherin Alpha 5 (Importin Alpha 6)1 2
Karyopherin Subunit Alpha-52 3
IPOA62
SRP62
Importin Alpha 62
Importin Subunit Alpha-62

External Ids:    HGNC: 63981   Entrez Gene: 38412   Ensembl: ENSG000001969117   OMIM: 6045455   UniProtKB: O151313   

Export aliases for KPNA5 gene to outside databases

Previous GC identifers: GC06P116845 GC06P117034 GC06P117056 GC06P117109 GC06P114581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KPNA5 Gene:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear
pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small
molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are
transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear
localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be
involved in NLS-dependent protein import into the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for KPNA5 Gene: 
KPNA5 (karyopherin alpha 5 (importin alpha 6)) is a protein-coding gene. Diseases associated with KPNA5 include influenza, and breast cancer, and among its related super-pathways are Interferon Signaling and Cell cycle Spindle assembly and chromosome separation. GO annotations related to this gene include protein transporter activity and protein binding. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and
STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes
influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KPNA5 gene promoter:
         Nkx3-1   Nkx3-1 v4   ISGF-3   AML1a   p53   FOXD3   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for KPNA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.2

KPNA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P117048:  view genomic region     (about GC identifiers)

Start:
117,002,350 bp from pter      End:
117,063,030 bp from pter
Size:
60,681 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131 (See protein sequence)
Recommended Name: Importin subunit alpha-6  
Size: 536 amino acids; 60349 Da
Subunit: Forms a complex with importin subunit beta-1
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH47409.1; Type=Erroneous initiation; Sequence=CAI20500.1; Type=Erroneous initiation;
Secondary accessions: B2RAI5 Q86X23

Explore the universe of human proteins at neXtProt for KPNA5: NX_O15131

Explore proteomics data for KPNA5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15131

  • KPNA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KPNA5 Protein Expression
    REFSEQ proteins: NP_002260.2  
    ENSEMBL proteins: 
     ENSP00000396791   ENSP00000357552   ENSP00000376302   ENSP00000348704  
    Reactome Protein details: O15131
    Human Recombinant Protein Products for KPNA5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KPNA5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KPNA5
    GenScript Custom Purified and Recombinant Proteins Services for KPNA5
    Novus Biologicals KPNA5 Protein
    Novus Biologicals KPNA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    KPNA5 for ontologies           About GeneDecksing



    KPNA5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KPNA5
    GenScript Custom Superior Antibodies Services for KPNA5
    Novus Biologicals KPNA5 Antibodies
    Abcam antibodies for KPNA5
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for KPNA5
    LSBio Antibodies in human, mouse, rat for KPNA5 

    Assay Products for KPNA5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KPNA5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KPNA5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O15131

    ProtoNet protein and cluster: O15131

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    KPNA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA6_HUMAN, O15131
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and
    STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes
    influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15057270
    GO:0008565protein transporter activity IEA--
         
    KPNA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KPNA5:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KPNA5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KPNA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KPNA5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KPNA5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KPNA5
    SwitchGear 3'UTR luciferase reporter plasmidKPNA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KPNA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KPNA5
    Sirion Biotech Customized adenovirus for overexpression of KPNA5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KPNA5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KPNA5 (NM_002269)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA5
    Sirion Biotech Customized lentivirus for stable overexpression of KPNA5 
                         Customized lentivirus expression plasmids for stable overexpression of KPNA5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KPNA5
    Search LifeMap BioReagents cell lines for KPNA5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KPNA5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    3Immune System
    Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KPNA5
        Cell cycle Spindle assembly and chromosome separation


    1 GeneGo (Thomson Reuters) Pathway for KPNA5
        Cell cycle Spindle assembly and chromosome separation

    5        Reactome Pathways for KPNA5
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Interferon Signaling
    ISG15 antiviral mechanism
    Immune System



    KPNA5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KPNA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for KPNA5 (O151311, 2, 3 ENSP000003487044) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANP32AP396872, 3, ENSP000004178644MINT-2860268 I2D: score=3 STRING: ENSP00000417864
    CDKN1BP465271, 3, ENSP000002288724EBI-540602,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    BRMS1Q9HCU93, ENSP000003960524I2D: score=2 STRING: ENSP00000396052
    RAC1P630003I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing substrate import into nucleus TAS9395085
    GO:0019221cytokine-mediated signaling pathway TAS--

    KPNA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KPNA5 (IMA6)

    1 HMDB Compound for KPNA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about KPNA5 / IMA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KPNA5 gene: 
    NM_002269.2  

    Unigene Cluster for KPNA5:

    Karyopherin alpha 5 (importin alpha 6)
    Hs.182971  [show with all ESTs]
    Unigene Representative Sequence: NM_002269
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413340 ENST00000368564 ENST00000392517 ENST00000356348(uc003pxh.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KPNA5
    SwitchGear 3'UTR luciferase reporter plasmidKPNA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KPNA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA5
    Clone
    Products:
         
    OriGene clones in human, mouse for KPNA5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KPNA5 (NM_002269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA5
    Sirion Biotech Customized lentivirus for stable overexpression of KPNA5 
                         Customized lentivirus expression plasmids for stable overexpression of KPNA5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KPNA5
    OriGene qSTAR qPCR primer pairs in human, mouse for KPNA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KPNA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA5

    Additional mRNA sequence: 

    AF005361.1 AK314206.1 BC047409.1 

    2 DOTS entries:

    DT.40125294  DT.305387 

    24/100 AceView cDNA sequences (see all 100):

    BE349094 BC047409 BM978384 CA942465 AA383172 CA433043 AA332147 R28143 
    AU120902 AW235093 AI350519 CA950341 AW169927 BX109586 CA950576 NM_002269 
    BX105417 AW027698 AA043363 BX491300 BU569601 U82778 BG572535 BM675278 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KPNA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KPNA5 Expression
    About this image


    See KPNA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KPNA5

    SOURCE GeneReport for Unigene cluster: Hs.182971

    UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
    Tissue specificity: Testis

        SABiosciences Custom PCR Arrays for KPNA5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KPNA5
    OriGene qSTAR qPCR primer pairs in human, mouse for KPNA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KPNA5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA5 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Kpna51 karyopherin alpha 5 (importin alpha 6) 89.61(n)
    94.03(a)
      294392  NM_001025113.1  NP_001020284.1 
    chicken
    (Gallus gallus)
    Aves KPNA51 karyopherin alpha 5 (importin alpha 6) 82.87(n)
    94.06(a)
      421738  XM_419770.3  XP_419770.2 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA56
    Uncharacterized protein
    91(a)
    1 ↔ 1
    1(185938965-185960788)
    zebrafish
    (Danio rerio)
    Actinopterygii kpna51 karyopherin alpha 5 (importin alpha 6) 73.78(n)
    89.42(a)
      553205  NM_001018153.1  NP_001018163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha13 protein-nucleus import protein carrier 61(a)
    (best of 2)
      76C6   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP16
    Karyopherin alpha homolog, forms a dimer with kary...
    50(a)
    1 → many
    XIV(284260-285888)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IMPA-41 importin alpha isoform 4 58.72(n)
    55.58(a)
      837448  NM_179292.2  NP_849623.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02533001 hypothetical protein 56.95(n)
    57.29(a)
      4327117  NM_001049146.1  NP_001042611.1 


    ENSEMBL Gene Tree for KPNA5 (if available)
    TreeFam Gene Tree for KPNA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KPNA5 gene
    KPNA72  KPNA32  SPAG62  KPNA22  KPNA42  KPNA62  KPNA12  
    5 SIMAP similar genes for KPNA5 using alignment to 3 protein entries:     IMA6_HUMAN (see all proteins):
    KPNA6    KPNA1    KPNA2    KPNA4    KPNA3

    KPNA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1165 SNPs in KPNA5 are shown (see all 1165)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362454
    A breast cancer sample4--see VAR_0362452 F L mis40--------
    VAR_0362464
    A breast cancer sample4--see VAR_0362462 R S mis40--------
    rs1381449571,2
    --117000541(+) AAGACA/GAAAGT 1 -- us2k10--------
    rs1436059711,2
    --117000627(+) ACCATA/GACAGT 1 -- us2k10--------
    rs1434958441,2
    C--117000708(+) GCCTG-/CCCCCC 1 -- us2k10--------
    rs1463322611,2
    C--117000791(+) GCTCA-/CCGCCT 1 -- us2k10--------
    rs1891548391,2
    --117000838(+) CACCAA/GGTCAG 1 -- us2k10--------
    rs65689611,2
    C,F,A--117000900(+) tacaaT/Aaaatt 1 -- us2k16Minor allele frequency- A:0.45WA NA CSA EA 246
    rs69218741,2
    C,F,A,H--117001133(+) taaacT/Gtgctt 1 -- us2k19Minor allele frequency- G:0.04NS EA NA WA 1204
    rs729599881,2
    C,F--117001166(+) GATTGG/ACAACG 1 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for KPNA5 (117002350 - 117063030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KPNA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732608CNV Deletion23290073
    nsv523972CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA5
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604545    OMIM disorders: --

    2 diseases for KPNA5:    About MalaCards
    influenza    breast cancer


    KPNA5 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KPNA5 (1 document)

    Export disorders for KPNA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KPNA5 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with KPNA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2, 3 Kohler M....Hartmann E. (1997)
    2. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (2003)
    3. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PubMed id 12740372)1, 2 Melen K....Julkunen I. (2003)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. The HIV-1 passage from cytoplasm to nucleus: the proce ss involving a complex exchange between the components of HIV-1 and cellular mac hinery to access nucleus and successful integration. (PubMed id 22509482)1 Jayappa K.D....Yao X. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    9. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker o f susceptibility for bladder cancer. (PubMed id 21460395)1 Gu J....Wu X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3841 HGNC: 6398 AceView: KPNA5 Ensembl:ENSG00000196911 euGenes: HUgn3841
    ECgene: KPNA5 H-InvDB: KPNA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KPNA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KPNA5 gene:
    Search GeneIP for patents involving KPNA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KPNA5  
     OriGene qPCR primer pairs and template standards for KPNA5   OriGene Protein Over-expression Lysate for KPNA5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KPNA5  
     OriGene qSTAR qPCR primer pairs in human, mouse for KPNA5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KPNA5   OriGene Custom Protein Services for KPNA5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPNA5
     QIAGEN SeqTarget long-range PCR primers for resequencing KPNA5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA5
     GenScript Custom Purified and Recombinant Proteins Services for KPNA5 GenScript cDNA clones with any tag delivered in your preferred vector for KPNA5
     GenScript Custom Assay Services for KPNA5 GenScript Custom Superior Antibodies Services for KPNA5
     GenScript Custom overexpressing Cell Line Services for KPNA5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KPNA5 promoter
     Search Chromatin IP Primers for KPNA5
     RT2 qPCR Primer Assay in human, mouse / rat KPNA5
     Search GNC Networks for KPNA5
     SABiosciences Custom PCR Arrays for KPNA5
     Search Tocris compounds for KPNA5 (IMA6)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KPNA5 antibodies
     KPNA5 proteins
     KPNA5 lysates
     Antibodies for KPNA5
     See all of Abcam's Antibodies, Kits and Proteins for KPNA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for KPNA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA5
     SwitchGear 3'UTR luciferase reporter plasmids for KPNA5
     SwitchGear Promoter luciferase reporter plasmids for KPNA5
     ThermoFisher Antibodies for KPNA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KPNA5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KPNA5
    Customized:
     lentivirus for stable overexpression of KPNA5
     lentivirus expression plasmids for stable overexpression of KPNA5
     adenovirus for overexpression of KPNA5
     LSBio Antibodies in human, mouse, rat for KPNA5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KPNA5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4