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Aliases for KPNA5 Gene

Aliases for KPNA5 Gene

  • Karyopherin Subunit Alpha 5 2 3 5
  • Karyopherin Alpha 5 (Importin Alpha 6) 2 3
  • Importin Alpha 6 2 3
  • Karyopherin Subunit Alpha-5 4
  • Importin Subunit Alpha-6 3
  • Karyopherin Alpha 5 2
  • IPOA6 3
  • SRP6 3

External Ids for KPNA5 Gene

Previous GeneCards Identifiers for KPNA5 Gene

  • GC06P116845
  • GC06P117034
  • GC06P117056
  • GC06P117048
  • GC06P117109
  • GC06P114581

Summaries for KPNA5 Gene

Entrez Gene Summary for KPNA5 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA5 Gene

KPNA5 (Karyopherin Subunit Alpha 5) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA6.

UniProtKB/Swiss-Prot for KPNA5 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for KPNA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA5 Gene

Genomics for KPNA5 Gene

Regulatory Elements for KPNA5 Gene

Enhancers for KPNA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F116098 0.5 ENCODE 21 -580.4 -580436 4.7 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KPNA5 NT5DC1 COL10A1 TSPYL4 FRK GC06M116078
GH06F116501 1 Ensembl ENCODE 13 -179.7 -179686 0.8 HDAC1 KLF1 LEF1 ZIC2 ZFHX2 GATA3 CTBP1 ZBTB48 NCOR1 EGR2 RSPH4A FAM26F KPNA5 FAM26D ENSG00000234117 FAM26E
GH06F117544 0.5 ENCODE 13 +863.9 863881 1.0 ELF3 PKNOX1 MLX ARID4B SIN3A ZSCAN9 RAD21 RARA YY1 FOS GOPC KPNA5 DCBLD1 ENSG00000226181 NUS1 PIR41328 ENSG00000282218
GH06F116630 1.1 Ensembl ENCODE 10.6 -49.2 -49245 2.0 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 SP5 NFYC ZHX2 RSPH4A TRAPPC3L KPNA5 FAM26D GC06P116597 ZUFSP
GH06F116615 0.2 ENCODE 9.9 -64.7 -64680 1.2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF207 FOS ZNF263 RSPH4A KPNA5 RWDD1 GC06P116597 ZUFSP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KPNA5 on UCSC Golden Path with GeneCards custom track

Promoters for KPNA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001225336 614 3000 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for KPNA5 Gene

Chromosome:
6
Start:
116,681,086 bp from pter
End:
116,741,867 bp from pter
Size:
60,782 bases
Orientation:
Plus strand

Genomic View for KPNA5 Gene

Genes around KPNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA5 Gene

Proteins for KPNA5 Gene

  • Protein details for KPNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15131-IMA6_HUMAN
    Recommended name:
    Importin subunit alpha-6
    Protein Accession:
    O15131
    Secondary Accessions:
    • B2RAI5
    • Q86X23

    Protein attributes for KPNA5 Gene

    Size:
    536 amino acids
    Molecular mass:
    60349 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1.
    SequenceCaution:
    • Sequence=AAH47409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20500.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KPNA5 Gene

neXtProt entry for KPNA5 Gene

Post-translational modifications for KPNA5 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KPNA5 Gene

Domains & Families for KPNA5 Gene

Gene Families for KPNA5 Gene

Suggested Antigen Peptide Sequences for KPNA5 Gene

Graphical View of Domain Structure for InterPro Entry

O15131

UniProtKB/Swiss-Prot:

IMA6_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
  • Contains 10 ARM repeats.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA5: view

Function for KPNA5 Gene

Molecular function for KPNA5 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Ontology (GO) - Molecular Function for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15057270
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with KPNA5: view
genes like me logo Genes that share phenotypes with KPNA5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KPNA5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA5 Gene

Localization for KPNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA5 Gene COMPARTMENTS Subcellular localization image for KPNA5 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA --
GO:0005654 nucleoplasm IBA,TAS --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol IBA,TAS --
genes like me logo Genes that share ontologies with KPNA5: view

Pathways & Interactions for KPNA5 Gene

genes like me logo Genes that share pathways with KPNA5: view

Gene Ontology (GO) - Biological Process for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0019054 modulation by virus of host process TAS --
genes like me logo Genes that share ontologies with KPNA5: view

No data available for SIGNOR curated interactions for KPNA5 Gene

Drugs & Compounds for KPNA5 Gene

(1) Drugs for KPNA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA5: view

Transcripts for KPNA5 Gene

Unigene Clusters for KPNA5 Gene

Karyopherin alpha 5 (importin alpha 6):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KPNA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA5 Gene

No ASD Table

Relevant External Links for KPNA5 Gene

GeneLoc Exon Structure for
KPNA5
ECgene alternative splicing isoforms for
KPNA5

Expression for KPNA5 Gene

mRNA expression in normal human tissues for KPNA5 Gene

Protein differential expression in normal tissues from HIPED for KPNA5 Gene

This gene is overexpressed in Liver (27.7), Testis (15.2), Cervix (12.3), and Heart (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KPNA5 Gene



Protein tissue co-expression partners for KPNA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of KPNA5 Gene:

KPNA5

SOURCE GeneReport for Unigene cluster for KPNA5 Gene:

Hs.182971

mRNA Expression by UniProt/SwissProt for KPNA5 Gene:

O15131-IMA6_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with KPNA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KPNA5 Gene

Orthologs for KPNA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA5 34 35
  • 99.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA5 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA5 34 35
  • 95.3 (n)
cow
(Bos Taurus)
Mammalia KPNA5 34 35
  • 95.05 (n)
oppossum
(Monodelphis domestica)
Mammalia KPNA5 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna5 34
  • 89.61 (n)
chicken
(Gallus gallus)
Aves KPNA5 34 35
  • 82.81 (n)
lizard
(Anolis carolinensis)
Reptilia KPNA5 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kpna5 34 35
  • 73.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 36 35
  • 61 (a)
Pen 36
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 34 35
  • 58.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08580g 34
  • 57.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL150W 34
  • 54.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MOS6 34
  • 57.42 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10515 34
barley
(Hordeum vulgare)
Liliopsida Hv.1976 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut15 34
  • 58.01 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01249 34
  • 54.32 (n)
Species where no ortholog for KPNA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KPNA5 Gene

ENSEMBL:
Gene Tree for KPNA5 (if available)
TreeFam:
Gene Tree for KPNA5 (if available)

Paralogs for KPNA5 Gene

Paralogs for KPNA5 Gene

(6) SIMAP similar genes for KPNA5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KPNA5: view

Variants for KPNA5 Gene

Sequence variations from dbSNP and Humsavar for KPNA5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036245 A breast cancer sample
VAR_036246 A breast cancer sample
rs10046104 -- 116,692,521(+) CAAAA(C/T)ATATT intron-variant
rs10046142 -- 116,690,630(+) agagt(A/T)agact intron-variant
rs10046285 -- 116,690,082(+) attct(A/C)ttcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA5 Gene

Variant ID Type Subtype PubMed ID
esv2732608 CNV deletion 23290073
nsv523972 CNV gain 19592680

Variation tolerance for KPNA5 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA5 Gene

Disorders for KPNA5 Gene

Relevant External Links for KPNA5

Human Genome Epidemiology (HuGE) Navigator
KPNA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA5

No disorders were found for KPNA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPNA5 Gene

Publications for KPNA5 Gene

  1. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Koehler M. … Hartmann E. (FEBS Lett. 1997) 2 3 4 64
  2. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P. … Stamminger T. (J. Virol. 2003) 3 4 64
  3. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PMID: 12740372) Melen K. … Julkunen I. (J. Biol. Chem. 2003) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for KPNA5 Gene

Sources for KPNA5 Gene

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