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KPNA5 Gene

protein-coding   GIFtS: 61
GCID: GC06P117048

Karyopherin Alpha 5 (Importin Alpha 6)

  Search for KPNA5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Karyopherin Alpha 5 (Importin Alpha 6)1 2
Karyopherin Subunit Alpha-52 3
IPOA62
SRP62
Importin Alpha 62
Importin Subunit Alpha-62

External Ids:    HGNC: 63981   Entrez Gene: 38412   Ensembl: ENSG000001969117   OMIM: 6045455   UniProtKB: O151313   

Export aliases for KPNA5 gene to outside databases

Previous GC identifers: GC06P116845 GC06P117034 GC06P117056 GC06P117109 GC06P114581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KPNA5 Gene:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear
pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small
molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are
transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear
localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be
involved in NLS-dependent protein import into the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for KPNA5 Gene:
KPNA5 (karyopherin alpha 5 (importin alpha 6)) is a protein-coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and
STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes
influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KPNA5 gene promoter:
         Nkx3-1   Nkx3-1 v4   ISGF-3   AML1a   p53   FOXD3   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA5 promoter sequence
   Search Chromatin IP Primers for KPNA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KPNA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.2

KPNA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P117048:  view genomic region     (about GC identifiers)

Start:
117,002,350 bp from pter      End:
117,063,030 bp from pter
Size:
60,681 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131 (See protein sequence)
Recommended Name: Importin subunit alpha-6  
Size: 536 amino acids; 60349 Da
Subunit: Forms a complex with importin subunit beta-1
Sequence caution: Sequence=AAH47409.1; Type=Erroneous initiation; Sequence=CAI20500.1; Type=Erroneous initiation;
Secondary accessions: B2RAI5 Q86X23

Explore the universe of human proteins at neXtProt for KPNA5: NX_O15131

Explore proteomics data for KPNA5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46, Lys131, Lys396
  • Modification sites at PhosphoSitePlus

  • See KPNA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002260.2  
    ENSEMBL proteins: 
     ENSP00000396791   ENSP00000357552   ENSP00000376302   ENSP00000348704  
    Reactome Protein details: O15131

    KPNA5 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KPNA5 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O15131

    ProtoNet protein and cluster: O15131

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Find genes that share domains with KPNA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA6_HUMAN, O15131
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and
    STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes
    influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15057270
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with KPNA5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KPNA5:
     Decreased POU5F1-GFP protein e 

    Animal Models:
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    miRTarBase miRNAs that target KPNA5:
    hsa-mir-192-5p (MIRT026470), hsa-mir-196a-5p (MIRT026068), hsa-let-7d-5p (MIRT032180)

    Block miRNA regulation of human, mouse, rat KPNA5 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMA6_HUMAN, O15131: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with KPNA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KPNA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation


    Find genes that share SuperPaths with KPNA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KPNA5
        Cell cycle Spindle assembly and chromosome separation

    1 Reactome Pathway for KPNA5
        ISG15 antiviral mechanism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KPNA5
    Interactions:

        Search GeneGlobe Interaction Network for KPNA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KPNA5 (O151311, 2, 3 ENSP000003487044) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANP32AP396872, 3, ENSP000004178644MINT-2860268 I2D: score=3 STRING: ENSP00000417864
    CDKN1BP465271, 3, ENSP000002288724EBI-540602,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    BRMS1Q9HCU93, ENSP000003960524I2D: score=2 STRING: ENSP00000396052
    RAC1P630003I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing protein import into nucleus TAS9395085
    GO:0019221cytokine-mediated signaling pathway TAS--

    Find genes that share ontologies with KPNA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KPNA5 (IMA6)

    1 HMDB Compound for KPNA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KPNA5 gene: 
    NM_002269.2  

    Unigene Cluster for KPNA5:

    Karyopherin alpha 5 (importin alpha 6)
    Hs.182971  [show with all ESTs]
    Unigene Representative Sequence: NM_002269
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413340 ENST00000368564 ENST00000392517 ENST00000356348(uc003pxh.3)

    miRNA
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    Additional mRNA sequence: 

    AF005361.1 AK314206.1 BC047409.1 

    2 DOTS entries:

    DT.40125294  DT.305387 

    Selected AceView cDNA sequences (see all 100):

    CA433043 CA942465 AA383172 AU120902 AI350519 AW235093 BC047409 CA950576 
    BE349094 BX109586 AA332147 CA950341 AW169927 BX105417 R28143 NM_002269 
    BM978384 BQ008760 AA204644 AW439748 BU742058 BG722891 AI829642 BF514198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KPNA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KPNA5 Expression
    About this image

    KPNA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KPNA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182971

    UniProtKB/Swiss-Prot: IMA6_HUMAN, O15131
    Tissue specificity: Testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA5 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Kpna51 karyopherin alpha 5 (importin alpha 6) 89.61(n)
    94.03(a)
      294392  NM_001025113.1  NP_001020284.1 
    chicken
    (Gallus gallus)
    Aves KPNA51 karyopherin alpha 5 (importin alpha 6) 82.81(n)
    93.88(a)
      421738  XM_004940285.1  XP_004940342.1 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA56
    karyopherin alpha 5 (importin alpha 6)
    91(a)
    1 ↔ 1
    1(185938965-185960788)
    zebrafish
    (Danio rerio)
    Actinopterygii kpna51 karyopherin alpha 5 (importin alpha 6) 73.78(n)
    89.42(a)
      553205  NM_001018153.1  NP_001018163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha13 protein-nucleus import protein carrier 61(a)
    (best of 2)
      76C6   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP11 SRP1 58.65(n)
    54.71(a)
      855532   NP_014210.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MOS61 MOS6 57.42(n)
    55.9(a)
      827472  NM_116447.2  NP_192124.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.19762 Transcribed sequence with moderate similarity to protein more 75.63(n)    BU979233.1 


    ENSEMBL Gene Tree for KPNA5 (if available)
    TreeFam Gene Tree for KPNA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KPNA5 gene
    KPNA72  KPNA32  SPAG62  KPNA22  KPNA42  KPNA62  KPNA12  
    6 SIMAP similar genes for KPNA5 using alignment to 3 protein entries:     IMA6_HUMAN (see all proteins):
    KPNA6    KPNA1    KPNA3    KPNA4    KPNA2    KPNA7

    Find genes that share paralogs with KPNA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KPNA5 (see all 1165)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362454
    A breast cancer sample4--see VAR_0362452 F L mis40--------
    VAR_0362464
    A breast cancer sample4--see VAR_0362462 R S mis40--------
    rs1381449571,2
    --117000541(+) AAGACA/GAAAGT 1 -- us2k10--------
    rs1436059711,2
    --117000627(+) ACCATA/GACAGT 1 -- us2k10--------
    rs1434958441,2
    C--117000708(+) GCCTG-/CCCCCC 1 -- us2k10--------
    rs1463322611,2
    C--117000791(+) GCTCA-/CCGCCT 1 -- us2k10--------
    rs1891548391,2
    --117000838(+) CACCAA/GGTCAG 1 -- us2k10--------
    rs65689611,2
    C,F,A--117000900(+) tacaaT/Aaaatt 1 -- us2k16Minor allele frequency- A:0.45WA NA CSA EA 246
    rs69218741,2
    C,F,A,H--117001133(+) taaacT/Gtgctt 1 -- us2k19Minor allele frequency- G:0.04NS EA NA WA 1204
    rs729599881,2
    C,F--117001166(+) GATTGG/ACAACG 1 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for KPNA5 (117002350 - 117063030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KPNA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732608CNV Deletion23290073
    nsv523972CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA5
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604545    OMIM disorders: --


    Find genes that share disorders with KPNA5           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: KPNA5 (1 document)

    Export disorders for KPNA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KPNA5 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with KPNA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2, 3 Koehler M.... Hartmann E. (FEBS Lett. 1997)
    2. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (J. Virol. 2003)
    3. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PubMed id 12740372)1, 2 Melen K....Julkunen I. (J. Biol. Chem. 2003)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. (PubMed id 22509482)1 Jayappa K.D....Yao X. (Int J Biochem Mol Biol 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. (PubMed id 21460395)1 Gu J....Wu X. (Cancer Prev Res (Phila) 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. (PubMed id 20406804)1 Yang S.N....Kobe B. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3841 HGNC: 6398 AceView: KPNA5 Ensembl:ENSG00000196911 euGenes: HUgn3841
    ECgene: KPNA5 H-InvDB: KPNA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KPNA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KPNA5 gene:
    Search GeneIP for patents involving KPNA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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