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Aliases for KPNA5 Gene

Aliases for KPNA5 Gene

  • Karyopherin Alpha 5 (Importin Alpha 6) 2 3
  • Karyopherin Subunit Alpha-5 3 4
  • Importin Alpha 6 3
  • IPOA6 3
  • SRP6 3

External Ids for KPNA5 Gene

Previous GeneCards Identifiers for KPNA5 Gene

  • GC06P116845
  • GC06P117034
  • GC06P117056
  • GC06P117048
  • GC06P117109
  • GC06P114581

Summaries for KPNA5 Gene

Entrez Gene Summary for KPNA5 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA5 Gene

KPNA5 (Karyopherin Alpha 5 (Importin Alpha 6)) is a Protein Coding gene. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA5 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA5 Gene

Genomics for KPNA5 Gene

Regulatory Elements for KPNA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KPNA5 Gene

Chromosome:
6
Start:
116,681,086 bp from pter
End:
116,741,867 bp from pter
Size:
60,782 bases
Orientation:
Plus strand

Genomic View for KPNA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA5 Gene

Proteins for KPNA5 Gene

  • Protein details for KPNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15131-IMA6_HUMAN
    Recommended name:
    Importin subunit alpha-6
    Protein Accession:
    O15131
    Secondary Accessions:
    • B2RAI5
    • Q86X23

    Protein attributes for KPNA5 Gene

    Size:
    536 amino acids
    Molecular mass:
    60349 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1
    SequenceCaution:
    • Sequence=AAH47409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20500.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KPNA5 Gene

neXtProt entry for KPNA5 Gene

Proteomics data for KPNA5 Gene at MOPED

Post-translational modifications for KPNA5 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for KPNA5 Gene

Antibody Products

No data available for DME Specific Peptides for KPNA5 Gene

Domains & Families for KPNA5 Gene

Gene Families for KPNA5 Gene

Suggested Antigen Peptide Sequences for KPNA5 Gene

Graphical View of Domain Structure for InterPro Entry

O15131

UniProtKB/Swiss-Prot:

IMA6_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import
  • Belongs to the importin alpha family.
  • Contains 10 ARM repeats.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA5: view

Function for KPNA5 Gene

Molecular function for KPNA5 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Ontology (GO) - Molecular Function for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 15057270
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with KPNA5: view
genes like me logo Genes that share phenotypes with KPNA5: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA5 Gene

Localization for KPNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA5 Gene COMPARTMENTS Subcellular localization image for KPNA5 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA5: view

Pathways & Interactions for KPNA5 Gene

genes like me logo Genes that share pathways with KPNA5: view

Pathways by source for KPNA5 Gene

Gene Ontology (GO) - Biological Process for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0019048 modulation by virus of host morphology or physiology TAS --
GO:0019054 modulation by virus of host process TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with KPNA5: view

No data available for SIGNOR curated interactions for KPNA5 Gene

Drugs & Compounds for KPNA5 Gene

(1) Drugs for KPNA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA5: view

Transcripts for KPNA5 Gene

Unigene Clusters for KPNA5 Gene

Karyopherin alpha 5 (importin alpha 6):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA5 Gene

No ASD Table

Relevant External Links for KPNA5 Gene

GeneLoc Exon Structure for
KPNA5
ECgene alternative splicing isoforms for
KPNA5

Expression for KPNA5 Gene

mRNA expression in normal human tissues for KPNA5 Gene

Protein differential expression in normal tissues from HIPED for KPNA5 Gene

This gene is overexpressed in Liver (27.7), Testis (15.2), Cervix (12.3), and Heart (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA5 Gene



SOURCE GeneReport for Unigene cluster for KPNA5 Gene Hs.182971

mRNA Expression by UniProt/SwissProt for KPNA5 Gene

O15131-IMA6_HUMAN
Tissue specificity: Testis
genes like me logo Genes that share expression patterns with KPNA5: view

Protein tissue co-expression partners for KPNA5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KPNA5 Gene

Orthologs for KPNA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KPNA5 35
  • 95.05 (n)
  • 98.33 (a)
KPNA5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA5 35
  • 95.3 (n)
  • 99.07 (a)
KPNA5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KPNA5 35
  • 99.81 (n)
  • 99.63 (a)
KPNA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna5 35
  • 89.61 (n)
  • 94.03 (a)
oppossum
(Monodelphis domestica)
Mammalia KPNA5 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA5 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves KPNA5 35
  • 82.81 (n)
  • 93.88 (a)
KPNA5 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA5 36
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kpna5 35
  • 73.78 (n)
  • 89.42 (a)
kpna5 36
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 37
  • 61 (a)
Pen 37
  • 47 (a)
Kap-alpha1 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ima-2 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL150W 35
  • 54.49 (n)
  • 54.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08580g 35
  • 57.64 (n)
  • 54.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 35
  • 58.65 (n)
  • 54.71 (a)
SRP1 36
  • 51 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MOS6 35
  • 57.42 (n)
  • 55.9 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10515 35
barley
(Hordeum vulgare)
Liliopsida Hv.1976 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01249 35
  • 54.32 (n)
  • 61.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut15 35
  • 58.01 (n)
  • 56.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for KPNA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KPNA5 Gene

ENSEMBL:
Gene Tree for KPNA5 (if available)
TreeFam:
Gene Tree for KPNA5 (if available)

Paralogs for KPNA5 Gene

Paralogs for KPNA5 Gene

(6) SIMAP similar genes for KPNA5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KPNA5: view

Variants for KPNA5 Gene

Sequence variations from dbSNP and Humsavar for KPNA5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13590 -- 116,734,601(+) TGTTA(A/T)GAGTT intron-variant
rs488511 -- 116,731,201(+) TCTGT(A/G)TTAAG intron-variant
rs500176 -- 116,711,183(-) ggcgc(A/G)gtggc intron-variant
rs567568 -- 116,707,218(+) ATTTA(A/G)TAATG intron-variant
rs598405 -- 116,731,908(-) TCATA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA5 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680
esv2732608 CNV Deletion 23290073

Variation tolerance for KPNA5 Gene

Residual Variation Intolerance Score: 23.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA5 Gene

HapMap Linkage Disequilibrium report
KPNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA5 Gene

Disorders for KPNA5 Gene

Relevant External Links for KPNA5

Human Genome Epidemiology (HuGE) Navigator
KPNA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA5
genes like me logo Genes that share disorders with KPNA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPNA5 Gene

Publications for KPNA5 Gene

  1. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. (PMID: 17928350) Reid S.P. … Basler C.F. (J. Virol. 2007) 23 67
  2. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Koehler M. … Hartmann E. (FEBS Lett. 1997) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. (PMID: 25121748) Xu W. … Amarasinghe G.K. (Cell Host Microbe 2014) 67

Products for KPNA5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KPNA5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA5
    • Block miRNA regulation of KPNA5 using miScript Target Protectors

    Sources for KPNA5 Gene

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