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KPNA4 Gene

protein-coding   GIFtS: 64
GCID: GC03M160212

Karyopherin Alpha 4 (Importin Alpha 3)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Karyopherin Alpha 4 (Importin Alpha 3)1 2     SRP32
QIP12 3 5     Importin Subunit Alpha-32
Importin Alpha Q12 3     Importin Subunit Alpha-42
Karyopherin Subunit Alpha-42 3     Qip13
IPOA32     

External Ids:    HGNC: 63971   Entrez Gene: 38402   Ensembl: ENSG000001864327   OMIM: 6029705   UniProtKB: O006293   

Export aliases for KPNA4 gene to outside databases

Previous GC identifers: GC03M157685 GC03M161165 GC03M161499 GC03M161538 GC03M161700 GC03M157616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KPNA4 Gene:
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization
signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing
proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with
Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA
helicase Q1 and SV40 T antigen. (provided by RefSeq, Jul 2008)

GeneCards Summary for KPNA4 Gene:
KPNA4 (karyopherin alpha 4 (importin alpha 3)) is a protein-coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA3_HUMAN, O00629
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KPNA4 gene promoter:
         AhR   CBF-C   Arnt   HEN1   CREB   CBF-B   CBF-A   deltaCREB   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA4 promoter sequence
   Search Chromatin IP Primers for KPNA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KPNA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.33   Ensembl cytogenetic band:  3q25.33   HGNC cytogenetic band: 3q25.33

KPNA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M160212:  view genomic region     (about GC identifiers)

Start:
160,212,783 bp from pter      End:
160,283,376 bp from pter
Size:
70,594 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IMA3_HUMAN, O00629 (See protein sequence)
Recommended Name: Importin subunit alpha-3  
Size: 521 amino acids; 57887 Da
Subunit: Forms a complex with importin subunit beta-1. Interacts with SNAI1
Caution: Was termed (PubMed:9395085) importin alpha-3
Secondary accessions: A8K4S6 D3DNM2 O00190

Explore the universe of human proteins at neXtProt for KPNA4: NX_O00629

Explore proteomics data for KPNA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys386
  • Modification sites at PhosphoSitePlus

  • See KPNA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002259.1  
    ENSEMBL proteins: 
     ENSP00000334373   ENSP00000417172  
    Reactome Protein details: O00629

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for KPNA4 (4 products) 

     
    antibodies-online peptides for KPNA4

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    antibodies-online antibodies for KPNA4 (46 products) 

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    antibodies-online kits for KPNA4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O00629

    ProtoNet protein and cluster: O00629

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA3_HUMAN, O00629
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Find genes that share domains with KPNA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA3_HUMAN, O00629
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI9168958
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with KPNA4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KPNA4:
     Increased circadian period len  Increased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kpna4):
     normal 

    Find genes that share phenotypes with KPNA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kpna4tm1Bdr for KPNA4

       genOway: Develop your customized and physiologically relevant rodent model for KPNA4

    miRNA
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    miRTarBase miRNAs that target KPNA4:
    hsa-mir-375 (MIRT019944), hsa-mir-30a-5p (MIRT028598)

    Block miRNA regulation of human, mouse, rat KPNA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KPNA4 (see all 263):
    hsa-miR-124* hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-376b hsa-miR-502-3p hsa-miR-761 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidKPNA4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KPNA4

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    Addgene plasmids for KPNA4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMA3_HUMAN, O00629: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with KPNA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KPNA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2GPCR Pathway
    NFAT in Immune Response0.58
    3Prolactin Signaling Pathway
    Leptin signaling pathway0.35
    4Ran Pathway
    Ran Pathway
    5Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation


    Find genes that share SuperPaths with KPNA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KPNA4
        Ran Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA4
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA4
        Leptin signaling pathway


    1 Reactome Pathway for KPNA4
        ISG15 antiviral mechanism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KPNA4
    Interactions:

        GeneGlobe Interaction Network for KPNA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KPNA4 (O006291, 2, 3 ENSP000003343734) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RECQLP460631, 2, 3, ENSP000003954494EBI-396343,EBI-2823728 MINT-6733224 MINT-6733208 I2D: score=3 STRING: ENSP00000395449
    NFKB1P198382, 3MINT-48651 MINT-48538 I2D: score=1 
    H3F3AP842433, ENSP000003557784I2D: score=1 STRING: ENSP00000355778
    IPO5O004103, ENSP000002615744I2D: score=3 STRING: ENSP00000261574
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing protein import into nucleus TAS9395085
    GO:0019221cytokine-mediated signaling pathway TAS--

    Find genes that share ontologies with KPNA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KPNA4 (IMA3)

    1 HMDB Compound for KPNA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KPNA4 gene: 
    NM_002268.4  

    Unigene Cluster for KPNA4:

    Karyopherin alpha 4 (importin alpha 3)
    Hs.467866  [show with all ESTs]
    Unigene Representative Sequence: NM_002268
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334256(uc003fdn.3) ENST00000483437 ENST00000469804
    miRNA
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    hsa-miR-124* hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-376b hsa-miR-502-3p hsa-miR-761 hsa-miR-509-3-5p
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    Additional mRNA sequence: 

    AB002533.2 AF038199.1 AK021602.1 AK055675.1 AK129841.1 AK291041.1 BC007458.1 BC016754.1 
    BC028691.2 BC034493.2 BC052814.1 U93240.1 Y12393.1 

    12 DOTS entries:

    DT.91745423  DT.212079  DT.100045760  DT.121380979  DT.120841991  DT.95200464  DT.97868536  DT.100699562 
    DT.91980648  DT.91982676  DT.95077320  DT.100729944 

    Selected AceView cDNA sequences (see all 310):

    BE891180 CK905738 CD722448 BQ024334 BU521844 AW168295 BQ068146 F05473 
    BQ024536 AA603455 BM023145 AA887227 BM467072 F06764 CR597383 AI827407 
    AA565781 AW263745 BQ694698 BE932744 AA856745 AA894455 AK129841 BX281416 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KPNA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAAGTTT
    KPNA4 Expression
    About this image


    KPNA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Brain (Nervous System)
             Thalamus
    KPNA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KPNA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467866

    UniProtKB/Swiss-Prot: IMA3_HUMAN, O00629
    Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas,
    but barely detectable in kidney, thymus, colon and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KPNA4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kpna41 , 5 karyopherin (importin) alpha 41, 5 95.01(n)1
    98.85(a)1
      3 (32.18 cM)5
    166491  NM_008467.41  NP_032493.11 
     690671495 
    chicken
    (Gallus gallus)
    Aves KPNA41 karyopherin alpha 4 (importin alpha 3) 87.65(n)
    99.04(a)
      425012  NM_001007963.1  NP_001007964.1 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA46
    karyopherin alpha 4 (importin alpha 3)
    94(a)
    1 ↔ 1
    3(12949957-12975187)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96312 Xenopus laevis transcribed sequence with strong similarity more 87.35(n)    BU907934.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045358.12   -- 77.54(n)   327373  BC045358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha31 , 3 protein-nucleus import protein carrier3
    karyopherin alpha31
    67(a)
    (best of 4)3
    61.37(n)1
    67.65(a)1
      85D253
    411581  NM_001170101.11  NP_001163572.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ima-31 , 3 importin alpha, nuclear transport
    factor3
    ima-31
    63(a)
    (best of 2)3
    61.82(n)1
    64.14(a)1
      IV(7559979-7561848)3
    1775331  NM_068826.41  NP_501227.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP16
    Karyopherin alpha homolog, forms a dimer with kary...
    43(a)
    1 → many
    XIV(284260-285888) YNL189W


    ENSEMBL Gene Tree for KPNA4 (if available)
    TreeFam Gene Tree for KPNA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KPNA4 gene
    KPNA72  KPNA32  SPAG62  KPNA52  KPNA22  KPNA62  KPNA12  
    6 SIMAP similar genes for KPNA4 using alignment to 4 protein entries:     IMA3_HUMAN (see all proteins):
    KPNA3    KPNA2    KPNA7    KPNA5    KPNA1    KPNA6

    Find genes that share paralogs with KPNA4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KPNA4
    PGOHUM00000241350


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KPNA4 (see all 1233)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473360581,2
    --160212436(+) TCTTAC/TTATAA 1 -- ds50010--------
    rs1878093051,2
    --160212452(+) TTCAAA/TAAATC 1 -- ds50010--------
    rs46798891,2
    C,F,A--160212479(+) CAAAAT/AATAAA 1 -- ds50019Minor allele frequency- A:0.44NA WA CSA EA 370
    rs1165992411,2
    F--160212694(+) CTATCG/AAAGGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1932686751,2
    C--160212743(+) TGTAGA/GTTGAA 1 -- ds50010--------
    rs1140775851,2
    F--160212790(+) AGAAAT/CTGCAT 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs1487928971,2
    C--160212873(+) TATGCC/TGACCT 1 -- ut310--------
    rs1176681831,2
    C,F--160212876(+) GCCGAC/TCTTGC 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1823839211,2
    --160212904(+) TCTAGC/TGGAAA 1 -- ut310--------
    rs1424189131,2
    C--160212905(+) CTAGTG/TGAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KPNA4 (160212783 - 160283376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KPNA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726110CNV Deletion23290073
    esv2676156CNV Deletion23128226
    nsv877700CNV Loss21882294
    nsv877702CNV Loss21882294
    esv25090CNV Loss19812545
    nsv877701CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA4
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602970    OMIM disorders: --


    Find genes that share disorders with KPNA4           About GenesLikeMe

    Genetic Association Database (GAD): KPNA4

    Export disorders for KPNA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KPNA4 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with KPNA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. (PubMed id 9168958)1, 2, 3, 9 Seki T.... Enomoto T. (Biochem. Biophys. Res. Commun. 1997)
    2. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2, 3 Koehler M.... Hartmann E. (FEBS Lett. 1997)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (J. Virol. 2003)
    6. Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization. (PubMed id 10965137)1, 9 Ayala-Madrigal M.L....Hansmann I. (Cytogenet. Cell Genet. 2000)
    7. Importin I+3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. (PubMed id 23383277)1 Sasaki Y....Aida Y. (PLoS ONE 2013)
    8. UV-induced nuclear import of XPA is mediated by importin-I+4 in an ATR-dependent manner. (PubMed id 23861882)1 Li Z....Zou Y. (PLoS ONE 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3840 HGNC: 6397 AceView: KPNA4 Ensembl:ENSG00000186432 euGenes: HUgn3840
    ECgene: KPNA4 H-InvDB: KPNA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KPNA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KPNA4 gene:
    Search GeneIP for patents involving KPNA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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