KPNA4 Gene
protein-coding GIFtS: 59
GCID: GC03M160212
|
|
karyopherin alpha 4 (importin alpha 3)
| |
Aliases
for KPNA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Karyopherin Alpha 4 (Importin Alpha 3)1 2 | | Karyopherin Subunit Alpha-42 3 | | QIP11 2 3 5 | | MGC122171 | | IPOA31 2 | | MGC267031 | | SRP31 2 | | Importin Subunit Alpha-42 | | Importin Alpha Q12 3 | | Qip13 |
Export aliases for KPNA4 gene to outside databasesPrevious GC identifers: GC03M157685 GC03M161165 GC03M161499 GC03M161538 GC03M161700 GC03M157616 |
Summaries
for KPNA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KPNA4:
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localizationsignals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containingproteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopusimportin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1and SV40 T antigen. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IMA4_HUMAN, O00629Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex tothe nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex issubsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic sideof the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exportedfrom the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing anon-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classicalNLS
Gene Wiki entry for KPNA4
|
Genomic Views
for KPNA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KPNA4 gene promoter:
AhR CBF-C Arnt HEN1 CREB CBF-B CBF-A deltaCREB CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KPNA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.33 Ensembl cytogenetic band: 3q25.33 HGNC cytogenetic band: 3q25.33KPNA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M160212: view genomic region
(about GC identifiers)
Start:
|
160,212,783 bp from pter |
End:
|
160,283,376 bp from pter |
Size:
|
70,594 bases |
Orientation:
|
minus strand |
|
Proteins
for KPNA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IMA4_HUMAN, O00629 (See
protein sequence)Recommended Name: Importin subunit alpha-4 Size: 521 amino acids; 57887 Da
Subunit: Forms a complex with importin subunit beta-1. Interacts with SNAI1
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Caution: Was termed (PubMed:9395085) importin alpha-3
Secondary accessions: A8K4S6 D3DNM2 O00190Explore the universe of human proteins at neXtProt for KPNA4: NX_O00629
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00629
KPNA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002259.1
ENSEMBL proteins: ENSP00000334373 ENSP00000417172 Reactome Protein details: O00629
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KPNA4 for ontologies About GeneDecksing
KPNA4 Antibody Products:
Assay Products for KPNA4: |
Protein
Domains /
Families
for KPNA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KPNA4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00629ProtoNet protein and cluster: O00629 2 Blocks protein families: IPB000225 Armadillo repeat IPB002652 Importin alpha-like protein
UniProtKB/Swiss-Prot: IMA4_HUMAN, O00629Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a shorthydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain),which is sufficient for binding importin beta and essential for nuclear protein importDomain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internalautoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity forcytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus theinternal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity)Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs.Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of thecorresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)Similarity: Belongs to the importin alpha familySimilarity: Contains 10 ARM repeatsSimilarity: Contains 1 IBB domain |
Function
for KPNA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IMA4_HUMAN, O00629Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex tothe nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex issubsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic sideof the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exportedfrom the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing anon-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classicalNLS
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KPNA4 (NM_002268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPNA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0008565 | protein transporter activity |
IEA | -- |
KPNA4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KPNA4:
Animal Models:
Mouse knock-out Kpna4tm1Bdr for KPNA4
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Kpna4):
KPNA4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KPNA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Cytokine Signaling in Immune system | | | 4 | Immune System | | | 5 | Ran Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KPNA4
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KPNA4
1  GeneGo (Thomson Reuters) Pathway for KPNA4
1  BioSystems Pathway for KPNA4
5/6 
Reactome Pathways for KPNA4 (see all 6)
KPNA4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KPNA4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for KPNA4 (O006292, 3 ENSP000003343734) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006606 | protein import into nucleus |
-- | -- | | GO:0006607 | NLS-bearing substrate import into nucleus |
TAS | 9395085 | | GO:0019221 | cytokine-mediated signaling pathway |
TAS | -- |
KPNA4 for ontologies About GeneDecksing
|
Drugs & Compounds
for KPNA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KPNA4
1 HMDB Compound for KPNA4 About this table
Search CenterWatch for drugs/clinical trials and news about KPNA4 / IMA4
|
Transcripts
for KPNA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KPNA4 gene: NM_002268.4 Unigene Cluster for KPNA4: Karyopherin alpha 4 (importin alpha 3) Hs.467866 [show with all ESTs]Unigene Representative Sequence: NM_0022683 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334256(uc003fdn.3) ENST00000483437 ENST00000469804
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KPNA4 (NM_002268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPNA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA4 |
Additional cDNA sequence: AB002533.2 AF038199.1 AK021602.1 AK055675.1 AK129841.1 AK291041.1 BC007458.1 BC016754.1 BC028691.2 BC034493.2 BC052814.1 U93240.1 Y12393.1 12 DOTS entries: DT.91745423 DT.212079 DT.100045760 DT.121380979 DT.120841991 DT.95200464 DT.97868536 DT.100699562 DT.91980648 DT.91982676 DT.95077320 DT.100729944 24/310 AceView cDNA sequences (see all 310): W80392 AI827407 BQ694698 BU753004 BC007458 U93240 AA894455 BE932744 F06764 BQ024536 AA044281 AA731347 BC028691 BM982525 BQ127900 BQ024334 AI190898 AW168295 AW263745 BM467072 AA393851 AK129841 BQ549939 AA565781
GeneLoc Exon Structure
|
Expression
for KPNA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KPNA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAAAGTTT
About this image
See KPNA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KPNA4
SOURCE GeneReport for Unigene cluster: Hs.467866
UniProtKB/Swiss-Prot: IMA4_HUMAN, O00629Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, butbarely detectable in kidney, thymus, colon and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for KPNA4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KPNA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA4 |
Orthologs
for KPNA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KPNA4 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KPNA41 |
karyopherin alpha 4 (importin alpha 3) |
87.65(n)
99.04(a) |
|
425012 NM_001007963.1 NP_001007964.1 |
lizard
(Anolis carolinensis) |
Reptilia |
--KPNA46 |
-- |
94(a)89(a) |
1 ↔ 1possible ortholog |
3(12949957-12972623) 5(98814482-98815299) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.96312 |
Xenopus laevis transcribed sequence with strong similarity more |
87.35(n) |
|
BU907934.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC045358.12 |
-- |
77.54(n) |
|
327373 BC045358.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Kap-alpha31 , 3 |
protein-nucleus import protein carrier3
karyopherin alpha31 |
67(a)
(best of 4)3
61.62(n)1
68.13(a)1 |
|
85D253
411581 NM_001170101.11 NP_001163572.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ima-31 , 3 |
importin alpha, nuclear transport factor3
Protein IMA-31 |
63(a)
(best of 2)3
62.52(n)1
66.24(a)1 |
|
IV(7559979-7561848)3
1775331 NM_068826.31 NP_501227.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G328806 |
armadillo/beta-catenin-like repeats-containing pro... |
32(a) |
1 → many |
1(11913928-11914735) |
ENSEMBL Gene Tree for KPNA4 (if available)
TreeFam Gene Tree for KPNA4 (if available) |
Paralogs
for KPNA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KPNA4 gene
- KPNA32 KPNA72 SPAG62 KPNA52 KPNA22 KPNA12 KPNA62
6 SIMAP similar genes for KPNA4 using alignment to 4 protein entries: IMA4_HUMAN (see all proteins):KPNA3 KPNA2 KPNA7 KPNA5 KPNA1 KPNA6
KPNA4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KPNA4
PGOHUM00000241350
|
Genomic Variants
for KPNA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KPNA4 (160212783 - 160283376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KPNA4
1 CNV: 63635 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA4 |
|
Disorders
/ Diseases
for KPNA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KPNA4 for disorders About GeneDecksing
OMIM gene information: 602970
OMIM disorders: --
4  diseases for KPNA4: About MalaCardssost-related sclerosing bone dysplasia hermaphroditism immunodeficiency malaria
Export disorders for KPNA4 gene to outside databases
|
Publications
for KPNA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KPNA4 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with KPNA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. (PubMed id 9168958)1, 2, 3, 9 Seki T.... Enomoto T. (1997)
- Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2, 3 Kohler M....Hartmann E. (1997)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (2003)
- Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization. (PubMed id 10965137)1, 9 Ayala-Madrigal M.L....Hansmann I. (2000)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Cellular cofactors of lentiviral integrase: from targe t validation to drug discovery. (PubMed id 22928108)1 Taltynov O....Debyser Z. (2012)
- The HIV-1 passage from cytoplasm to nucleus: the proce ss involving a complex exchange between the components of HIV-1 and cellular mac hinery to access nucleus and successful integration. (PubMed id 22509482)1 Jayappa K.D....Yao X. (2012)
- 14-3-3 checkpoint regulatory proteins interact specif ically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (PubMed id 22222486)1 Andersen S.D....Rasmussen L.J. (2012)
|
External Searches for KPNA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KPNA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KPNA4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KPNA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KPNA4 gene:
Search GeneIP for patents involving KPNA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KPNA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for KPNA4 | | OriGene shRNA RFP for KPNA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA4 | | | OriGene Protein Over-expression Lysate for KPNA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KPNA4 | | OriGene 3'-UTR Clone for KPNA4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KPNA4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KPNA4 | | OriGene Custom Protein Services for KPNA4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPNA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA4 |
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| | | | Search Tocris compounds for KPNA4 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA4 |
|  |  |  | | | | ThermoFisher Antibody for KPNA4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA4 |
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