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Aliases for KPNA4 Gene

Aliases for KPNA4 Gene

  • Karyopherin Alpha 4 (Importin Alpha 3) 2 3
  • QIP1 3 4 6
  • Karyopherin Subunit Alpha-4 3 4
  • Importin Alpha Q1 3 4
  • Importin Subunit Alpha-3 3
  • Importin Subunit Alpha-4 3
  • IPOA3 3
  • SRP3 3

External Ids for KPNA4 Gene

Summaries for KPNA4 Gene

Entrez Gene Summary for KPNA4 Gene

  • The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA4 Gene

KPNA4 (Karyopherin Alpha 4 (Importin Alpha 3)) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Interferon Signaling. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA4 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA4 Gene

Genomics for KPNA4 Gene

Genomic Location for KPNA4 Gene

Start:
160,494,995 bp from pter
End:
160,565,588 bp from pter
Size:
70,594 bases
Orientation:
Minus strand

Genomic View for KPNA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA4 Gene

Regulatory Elements for KPNA4 Gene

Proteins for KPNA4 Gene

  • Protein details for KPNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00629-IMA3_HUMAN
    Recommended name:
    Importin subunit alpha-3
    Protein Accession:
    O00629
    Secondary Accessions:
    • A8K4S6
    • D3DNM2
    • O00190

    Protein attributes for KPNA4 Gene

    Size:
    521 amino acids
    Molecular mass:
    57887 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1. Interacts with SNAI1.

    Three dimensional structures from OCA and Proteopedia for KPNA4 Gene

neXtProt entry for KPNA4 Gene

Proteomics data for KPNA4 Gene at MOPED

Post-translational modifications for KPNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97 and Lys386

Other Protein References for KPNA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KPNA4 Gene

Domains for KPNA4 Gene

Gene Families for KPNA4 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • IPO :Importins

UniProtKB/Swiss-Prot:

IMA3_HUMAN
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import:
    • O00629
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).:
    • O00629
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).:
    • O00629
  • Contains 1 IBB domain.:
    • O00629
Family:
  • Belongs to the importin alpha family.:
    • O00629
Similarity:
  • Contains 10 ARM repeats.:
    • O00629
genes like me logo Genes that share domains with KPNA4: view

Function for KPNA4 Gene

Molecular function for KPNA4 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Ontology (GO) - Molecular Function for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 20554775
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with KPNA4: view

Phenotypes for KPNA4 Gene

genes like me logo Genes that share phenotypes with KPNA4: view

Animal Models for KPNA4 Gene

MGI Knock Outs for KPNA4:

miRNA for KPNA4 Gene

miRTarBase miRNAs that target KPNA4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KPNA4 Gene

Localization for KPNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA4 Gene COMPARTMENTS Subcellular localization image for KPNA4 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KPNA4: view

Pathways for KPNA4 Gene

genes like me logo Genes that share pathways with KPNA4: view

Pathways by source for KPNA4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KPNA4 Gene
2 Qiagen pathways for KPNA4 Gene

Gene Ontology (GO) - Biological Process for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0042542 response to hydrogen peroxide IEA --
genes like me logo Genes that share ontologies with KPNA4: view

Compounds for KPNA4 Gene

(1) HMDB Compounds for KPNA4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KPNA4: view

Transcripts for KPNA4 Gene

mRNA/cDNA for KPNA4 Gene

Unigene Clusters for KPNA4 Gene

Karyopherin alpha 4 (importin alpha 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA4 Gene

No ASD Table

Relevant External Links for KPNA4 Gene

GeneLoc Exon Structure for
KPNA4
ECgene alternative splicing isoforms for
KPNA4

Expression for KPNA4 Gene

mRNA expression in normal human tissues for KPNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA4 Gene

This gene is overexpressed in Muscle - Skeletal (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA4 Gene

SOURCE GeneReport for Unigene cluster for KPNA4 Gene Hs.467866

mRNA Expression by UniProt/SwissProt for KPNA4 Gene

O00629-IMA3_HUMAN
Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes
genes like me logo Genes that share expressions with KPNA4: view

Orthologs for KPNA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KPNA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA4 36
  • 99.87 (n)
  • 100 (a)
KPNA4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA4 36
  • 96.87 (n)
  • 99.81 (a)
KPNA4 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA4 36
  • 96.48 (n)
  • 99.81 (a)
KPNA4 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna4 36
  • 95.01 (n)
  • 98.85 (a)
Kpna4 16
Kpna4 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA4 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kpna4 36
  • 94.88 (n)
  • 98.85 (a)
chicken
(Gallus gallus)
Aves KPNA4 36
  • 87.65 (n)
  • 99.04 (a)
KPNA4 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA4 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9631 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna4 36
  • 82.5 (n)
  • 94.81 (a)
Str.5199 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
kpna4 36
  • 76.84 (n)
  • 95.59 (a)
kpna4 37
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001273 36
  • 60.64 (n)
  • 71.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha3 36
  • 61.37 (n)
  • 67.65 (a)
Kap-alpha3 37
  • 66 (a)
OneToMany
Kap-alpha3 38
  • 67 (a)
CG11040 38
  • 37 (a)
CG10478 38
  • 37 (a)
Pen 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-3 36
  • 61.82 (n)
  • 64.14 (a)
ima-3 37
  • 62 (a)
OneToMany
ima-3 38
  • 63 (a)
ima-2 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 37
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4017 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11131 37
  • 67 (a)
OneToMany
Species with no ortholog for KPNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA4 Gene

ENSEMBL:
Gene Tree for KPNA4 (if available)
TreeFam:
Gene Tree for KPNA4 (if available)

Paralogs for KPNA4 Gene

Paralogs for KPNA4 Gene

Selected SIMAP similar genes for KPNA4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KPNA4 Gene

genes like me logo Genes that share paralogs with KPNA4: view

Variants for KPNA4 Gene

Sequence variations from dbSNP and Humsavar for KPNA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs167783 -- 160,511,207(+) ttcac(A/G)ccatt intron-variant
rs226353 -- 160,511,218(+) ctcct(A/G)cctca intron-variant
rs226354 -- 160,511,295(+) agaga(C/T)ggggt intron-variant
rs324448 -- 160,511,128(+) tgaga(C/T)ggagt intron-variant
rs324449 -- 160,511,191(+) agctc(C/T)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA4 Gene

Variant ID Type Subtype PubMed ID
nsv877700 CNV Loss 21882294
nsv877701 CNV Loss 21882294
esv2676156 CNV Deletion 23128226
esv25090 CNV Loss 19812545
esv2726110 CNV Deletion 23290073
nsv877702 CNV Loss 21882294

Relevant External Links for KPNA4 Gene

HapMap Linkage Disequilibrium report
KPNA4

Disorders for KPNA4 Gene

Relevant External Links for KPNA4

Genetic Association Database (GAD)
KPNA4
genes like me logo Genes that share disorders with KPNA4: view

No data available for UniProtKB/Swiss-Prot for KPNA4 Gene

Publications for KPNA4 Gene

  1. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. (PMID: 9168958) Seki T. … Enomoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Koehler M. … Hartmann E. (FEBS Lett. 1997) 2 3 4
  3. Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization. (PMID: 10965137) Ayala-Madrigal M.L. … Hansmann I. (Cytogenet. Cell Genet. 2000) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P. … Stamminger T. (J. Virol. 2003) 3 4

Products for KPNA4 Gene

  • Addgene plasmids for KPNA4

Sources for KPNA4 Gene

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