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Aliases for KPNA4 Gene

Aliases for KPNA4 Gene

  • Karyopherin Subunit Alpha 4 2 3 5
  • Karyopherin Alpha 4 (Importin Alpha 3) 2 3
  • Importin Alpha Q1 3 4
  • QIP1 3 4
  • Karyopherin Subunit Alpha-4 4
  • Importin Subunit Alpha-3 3
  • Importin Subunit Alpha-4 3
  • Karyopherin Alpha 4 2
  • Importin Alpha 3 2
  • IPOA3 3
  • SRP3 3

External Ids for KPNA4 Gene

Previous GeneCards Identifiers for KPNA4 Gene

  • GC03M157685
  • GC03M161165
  • GC03M161499
  • GC03M161538
  • GC03M161700
  • GC03M160212
  • GC03M157616

Summaries for KPNA4 Gene

Entrez Gene Summary for KPNA4 Gene

  • The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA4 Gene

KPNA4 (Karyopherin Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA3.

UniProtKB/Swiss-Prot for KPNA4 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for KPNA4 Gene

Additional gene information for KPNA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA4 Gene

Genomics for KPNA4 Gene

Regulatory Elements for KPNA4 Gene

Enhancers for KPNA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H160128 1.3 FANTOM5 Ensembl ENCODE 8.3 +435.5 435543 2 TBP JUN CEBPB REST CEBPG BATF EP300 JUND POLR2A STAT3 IL12A KPNA4 BRD7P2 C3orf80
GH03H160665 1.2 Ensembl ENCODE 7 -101.1 -101069 3 HDGF GLIS2 ATF7 FOS RUNX3 DEK JUNB TSHZ1 MAFF STAT3 ENSG00000207084 KPNA4 ARL14 GC03P160584
GH03H160675 1.1 Ensembl ENCODE 6.2 -112.4 -112369 4 ELF3 FOXA2 JUN ZSCAN4 ARID4B RAD21 RFX5 TEAD3 ZNF664 GATA3 KPNA4 IFT80 ARL14 ENSG00000207084
GH03H160134 0.8 FANTOM5 Ensembl 8.2 +430.9 430888 0 CTCF JUND CREB1 FOSL2 FOS KPNA4 BRD7P2 C3orf80
GH03H160204 0.5 FANTOM5 8 +360.9 360896 0 ZFHX2 SPI1 IL12A-AS1 KPNA4 C3orf80 BRD7P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KPNA4 on UCSC Golden Path with GeneCards custom track

Promoters for KPNA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161234 188 3601 HDGF ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 SP5

Genomic Location for KPNA4 Gene

Chromosome:
3
Start:
160,494,995 bp from pter
End:
160,565,588 bp from pter
Size:
70,594 bases
Orientation:
Minus strand

Genomic View for KPNA4 Gene

Genes around KPNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA4 Gene

Proteins for KPNA4 Gene

  • Protein details for KPNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00629-IMA3_HUMAN
    Recommended name:
    Importin subunit alpha-3
    Protein Accession:
    O00629
    Secondary Accessions:
    • A8K4S6
    • D3DNM2
    • O00190

    Protein attributes for KPNA4 Gene

    Size:
    521 amino acids
    Molecular mass:
    57887 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1. Interacts with SNAI1. Interacts with human adenovirus 5 E1A protein; this interaction allows E1A import into the host nucleus (PubMed:23864635).

    Three dimensional structures from OCA and Proteopedia for KPNA4 Gene

neXtProt entry for KPNA4 Gene

Post-translational modifications for KPNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KPNA4 (Importin alpha 3/KPNA4)
  • Abcam antibodies for KPNA4

No data available for DME Specific Peptides for KPNA4 Gene

Domains & Families for KPNA4 Gene

Gene Families for KPNA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for KPNA4 Gene

Graphical View of Domain Structure for InterPro Entry

O00629

UniProtKB/Swiss-Prot:

IMA3_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
Family:
  • Belongs to the importin alpha family.
genes like me logo Genes that share domains with KPNA4: view

Function for KPNA4 Gene

Molecular function for KPNA4 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Phenotypes From GWAS Catalog for KPNA4 Gene

Gene Ontology (GO) - Molecular Function for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9168958
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with KPNA4: view
genes like me logo Genes that share phenotypes with KPNA4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KPNA4
  • Applied Biological Materials Clones for KPNA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA4 Gene

Localization for KPNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNA4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA --
GO:0005654 nucleoplasm IBA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
genes like me logo Genes that share ontologies with KPNA4: view

Pathways & Interactions for KPNA4 Gene

genes like me logo Genes that share pathways with KPNA4: view

Pathways by source for KPNA4 Gene

SIGNOR curated interactions for KPNA4 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0019054 modulation by virus of host process TAS --
genes like me logo Genes that share ontologies with KPNA4: view

Drugs & Compounds for KPNA4 Gene

(1) Drugs for KPNA4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA4: view

Transcripts for KPNA4 Gene

mRNA/cDNA for KPNA4 Gene

Unigene Clusters for KPNA4 Gene

Karyopherin alpha 4 (importin alpha 3):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KPNA4
  • Applied Biological Materials Clones for KPNA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA4 Gene

No ASD Table

Relevant External Links for KPNA4 Gene

GeneLoc Exon Structure for
KPNA4
ECgene alternative splicing isoforms for
KPNA4

Expression for KPNA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KPNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KPNA4 Gene



Protein tissue co-expression partners for KPNA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KPNA4 Gene:

KPNA4

SOURCE GeneReport for Unigene cluster for KPNA4 Gene:

Hs.467866

mRNA Expression by UniProt/SwissProt for KPNA4 Gene:

O00629-IMA3_HUMAN
Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for KPNA4 Gene

  • Nervous system(4.7)
  • Muscle(4.3)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with KPNA4: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNA4 Gene

Orthologs for KPNA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KPNA4 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia KPNA4 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KPNA4 33 34
  • 99.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KPNA4 33 34
  • 96.87 (n)
dog
(Canis familiaris)
Mammalia KPNA4 33 34
  • 96.48 (n)
mouse
(Mus musculus)
Mammalia Kpna4 33 16 34
  • 95.01 (n)
rat
(Rattus norvegicus)
Mammalia Kpna4 33
  • 94.88 (n)
chicken
(Gallus gallus)
Aves KPNA4 33 34
  • 87.65 (n)
lizard
(Anolis carolinensis)
Reptilia KPNA4 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna4 33
  • 82.5 (n)
Str.5199 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9631 33
zebrafish
(Danio rerio)
Actinopterygii kpna4 33 34
  • 76.84 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha3 35 33 34
  • 61.37 (n)
Pen 35
  • 46 (a)
CG10478 35
  • 37 (a)
CG11040 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001273 33
  • 60.64 (n)
worm
(Caenorhabditis elegans)
Secernentea ima-3 35 33 34
  • 61.82 (n)
ima-2 35
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 34
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11131 34
  • 67 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4017 33
Species where no ortholog for KPNA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA4 Gene

ENSEMBL:
Gene Tree for KPNA4 (if available)
TreeFam:
Gene Tree for KPNA4 (if available)

Paralogs for KPNA4 Gene

Paralogs for KPNA4 Gene

(6) SIMAP similar genes for KPNA4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KPNA4 Gene

genes like me logo Genes that share paralogs with KPNA4: view

Variants for KPNA4 Gene

Sequence variations from dbSNP and Humsavar for KPNA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000050200 -- 160,555,712(+) TATTA(A/T)ACTTC intron-variant
rs1000078123 -- 160,545,774(+) GGACC(A/G)GAGTG intron-variant
rs1000082153 -- 160,555,434(+) CCCAG(A/T)AGATG intron-variant
rs1000135434 -- 160,529,093(+) CCGGC(G/T)AATTT intron-variant
rs1000168920 -- 160,548,658(+) TATTC(C/T)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA4 Gene

Variant ID Type Subtype PubMed ID
esv25090 CNV loss 19812545
esv2676156 CNV deletion 23128226
esv2726110 CNV deletion 23290073
esv3598385 CNV loss 21293372
nsv963372 CNV duplication 23825009

Variation tolerance for KPNA4 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA4 Gene

Disorders for KPNA4 Gene

Relevant External Links for KPNA4

Genetic Association Database (GAD)
KPNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA4

No disorders were found for KPNA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPNA4 Gene

Publications for KPNA4 Gene

  1. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. (PMID: 9168958) Seki T … Enomoto T (Biochemical and biophysical research communications 1997) 2 3 4 22 60
  2. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Köhler M … Hartmann E (FEBS letters 1997) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P … Stamminger T (Journal of virology 2003) 3 4 60

Products for KPNA4 Gene

  • Addgene plasmids for KPNA4

Sources for KPNA4 Gene

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