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Aliases for KPNA4 Gene

Aliases for KPNA4 Gene

  • Karyopherin Subunit Alpha 4 2 3
  • Karyopherin Alpha 4 (Importin Alpha 3) 2 3 5
  • Karyopherin Subunit Alpha-4 3 4
  • Importin Alpha Q1 3 4
  • QIP1 3 4
  • Importin Subunit Alpha-4 3
  • Karyopherin Alpha 4 2
  • Importin Alpha 3 2
  • IPOA3 3
  • SRP3 3

External Ids for KPNA4 Gene

Previous GeneCards Identifiers for KPNA4 Gene

  • GC03M157685
  • GC03M161165
  • GC03M161499
  • GC03M161538
  • GC03M161700
  • GC03M160212
  • GC03M157616

Summaries for KPNA4 Gene

Entrez Gene Summary for KPNA4 Gene

  • The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA4 Gene

KPNA4 (Karyopherin Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA4 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for KPNA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA4 Gene

Genomics for KPNA4 Gene

Regulatory Elements for KPNA4 Gene

Promoters for KPNA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KPNA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KPNA4 Gene

Chromosome:
3
Start:
160,494,995 bp from pter
End:
160,565,588 bp from pter
Size:
70,594 bases
Orientation:
Minus strand

Genomic View for KPNA4 Gene

Genes around KPNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA4 Gene

Proteins for KPNA4 Gene

  • Protein details for KPNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00629-IMA3_HUMAN
    Recommended name:
    Importin subunit alpha-3
    Protein Accession:
    O00629
    Secondary Accessions:
    • A8K4S6
    • D3DNM2
    • O00190

    Protein attributes for KPNA4 Gene

    Size:
    521 amino acids
    Molecular mass:
    57887 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1. Interacts with SNAI1. Interacts with human adenovirus 5 E1A protein; this interaction allows E1A import into the host nucleus (PubMed:23864635).

    Three dimensional structures from OCA and Proteopedia for KPNA4 Gene

neXtProt entry for KPNA4 Gene

Proteomics data for KPNA4 Gene at MOPED

Post-translational modifications for KPNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KPNA4 (Importin alpha 3/KPNA4)

No data available for DME Specific Peptides for KPNA4 Gene

Domains & Families for KPNA4 Gene

Gene Families for KPNA4 Gene

Suggested Antigen Peptide Sequences for KPNA4 Gene

Graphical View of Domain Structure for InterPro Entry

O00629

UniProtKB/Swiss-Prot:

IMA3_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
  • Contains 10 ARM repeats.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA4: view

Function for KPNA4 Gene

Molecular function for KPNA4 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Ontology (GO) - Molecular Function for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with KPNA4: view
genes like me logo Genes that share phenotypes with KPNA4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA4 Gene

Localization for KPNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA4 Gene COMPARTMENTS Subcellular localization image for KPNA4 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KPNA4: view

Pathways & Interactions for KPNA4 Gene

genes like me logo Genes that share pathways with KPNA4: view

Pathways by source for KPNA4 Gene

SIGNOR curated interactions for KPNA4 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019054 modulation by virus of host process TAS --
GO:0042542 response to hydrogen peroxide IEA --
GO:0075733 intracellular transport of virus TAS --
genes like me logo Genes that share ontologies with KPNA4: view

Drugs & Compounds for KPNA4 Gene

(1) Drugs for KPNA4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA4: view

Transcripts for KPNA4 Gene

mRNA/cDNA for KPNA4 Gene

Unigene Clusters for KPNA4 Gene

Karyopherin alpha 4 (importin alpha 3):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA4 Gene

No ASD Table

Relevant External Links for KPNA4 Gene

GeneLoc Exon Structure for
KPNA4
ECgene alternative splicing isoforms for
KPNA4

Expression for KPNA4 Gene

mRNA expression in normal human tissues for KPNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA4 Gene



SOURCE GeneReport for Unigene cluster for KPNA4 Gene Hs.467866

mRNA Expression by UniProt/SwissProt for KPNA4 Gene

O00629-IMA3_HUMAN
Tissue specificity: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with KPNA4: view

Protein tissue co-expression partners for KPNA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for KPNA4 Gene

Orthologs for KPNA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KPNA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA4 36
  • 100 (a)
OneToOne
KPNA4 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia KPNA4 36
  • 100 (a)
OneToOne
KPNA4 35
  • 96.87 (n)
  • 99.81 (a)
dog
(Canis familiaris)
Mammalia KPNA4 35
  • 96.48 (n)
  • 99.81 (a)
KPNA4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna4 36
  • 99 (a)
OneToOne
Kpna4 16
Kpna4 35
  • 95.01 (n)
  • 98.85 (a)
oppossum
(Monodelphis domestica)
Mammalia KPNA4 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kpna4 35
  • 94.88 (n)
  • 98.85 (a)
chicken
(Gallus gallus)
Aves KPNA4 36
  • 99 (a)
OneToOne
KPNA4 35
  • 87.65 (n)
  • 99.04 (a)
lizard
(Anolis carolinensis)
Reptilia KPNA4 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9631 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna4 35
  • 82.5 (n)
  • 94.81 (a)
Str.5199 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
kpna4 35
  • 76.84 (n)
  • 95.59 (a)
kpna4 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001273 35
  • 60.64 (n)
  • 71.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha3 36
  • 66 (a)
OneToMany
CG10478 37
  • 37 (a)
CG11040 37
  • 37 (a)
Kap-alpha3 37
  • 67 (a)
Pen 37
  • 46 (a)
Kap-alpha3 35
  • 61.37 (n)
  • 67.65 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-3 36
  • 62 (a)
OneToMany
ima-2 37
  • 37 (a)
ima-3 37
  • 63 (a)
ima-3 35
  • 61.82 (n)
  • 64.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 36
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4017 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11131 36
  • 67 (a)
OneToMany
Species with no ortholog for KPNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA4 Gene

ENSEMBL:
Gene Tree for KPNA4 (if available)
TreeFam:
Gene Tree for KPNA4 (if available)

Paralogs for KPNA4 Gene

Paralogs for KPNA4 Gene

(6) SIMAP similar genes for KPNA4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KPNA4 Gene

genes like me logo Genes that share paralogs with KPNA4: view

Variants for KPNA4 Gene

Sequence variations from dbSNP and Humsavar for KPNA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs167783 -- 160,511,207(+) ttcac(A/G)ccatt intron-variant
rs324448 -- 160,511,128(+) tgaga(C/T)ggagt intron-variant
rs324449 -- 160,511,191(+) agctc(C/T)gcctc intron-variant
rs324450 -- 160,511,198(+) cctcc(C/T)gggtt intron-variant
rs1056669 -- 160,495,314(-) TCAAC(C/T)GCACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KPNA4 Gene

Variant ID Type Subtype PubMed ID
nsv877700 CNV Loss 21882294
nsv877701 CNV Loss 21882294
esv2676156 CNV Deletion 23128226
esv25090 CNV Loss 19812545
esv2726110 CNV Deletion 23290073
nsv877702 CNV Loss 21882294

Variation tolerance for KPNA4 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA4 Gene

HapMap Linkage Disequilibrium report
KPNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA4 Gene

Disorders for KPNA4 Gene

Relevant External Links for KPNA4

Genetic Association Database (GAD)
KPNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA4

No disorders were found for KPNA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPNA4 Gene

Publications for KPNA4 Gene

  1. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. (PMID: 9168958) Seki T. … Enomoto T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization. (PMID: 10965137) Ayala-Madrigal M.L. … Hansmann I. (Cytogenet. Cell Genet. 2000) 3 23
  3. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Koehler M. … Hartmann E. (FEBS Lett. 1997) 2 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for KPNA4 Gene

Sources for KPNA4 Gene

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