Aliases for KPNA3 Gene
External Ids for KPNA3 Gene
Previous GeneCards Identifiers for KPNA3 Gene
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
GeneCards Summary for KPNA3 Gene
KPNA3 (Karyopherin Alpha 3 (Importin Alpha 4)) is a Protein Coding gene. Diseases associated with KPNA3 include opiate dependence. Among its related pathways are GPCR Pathway and Interferon Signaling. GO annotations related to this gene include protein C-terminus binding and nuclear localization sequence binding. An important paralog of this gene is KPNA1.
UniProtKB/Swiss-Prot for KPNA3 Gene
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9