KPNA3 Gene
protein-coding GIFtS: 62
GCID: GC13M050273
|
|
karyopherin alpha 3 (importin alpha 4)
| |
Aliases
for KPNA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Karyopherin Alpha 3 (Importin Alpha 4)1 2 | | SRP12 | | IPOA41 2 | | Importin Alpha 42 | | SRP1gamma1 2 | | Importin Alpha-32 | | SRP41 2 | | Importin Subunit Alpha-32 | | HSRP11 | | Importin-Alpha-Q21 | | Importin Alpha Q22 3 | | Qip23 | | Karyopherin Subunit Alpha-32 3 | | QIP23 | | SRP1-Gamma1 | | Qip23 |
Export aliases for KPNA3 gene to outside databasesPrevious GC identifers: GC13M048275 GC13M044262 GC13M049210 GC13M048071 GC13M049172 GC13M031066 |
Summaries
for KPNA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KPNA3:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear porecomplex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore bynonselective diffusion while larger molecules are transported by an active process. The protein encoded by this genebelongs to the importin alpha family, and is involved in nuclear protein import. (provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: IMA3_HUMAN, O00505Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex tothe nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex issubsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic sideof the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exportedfrom the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing anon-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9
Gene Wiki entry for KPNA3
|
Genomic Views
for KPNA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KPNA3 gene promoter:
RFX1 p53 Brachyury Nkx2-2 RREB-1 C/EBPalpha CHOP-10 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KPNA3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.3KPNA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M050273: view genomic region
(about GC identifiers)
Start:
|
50,273,443 bp from pter |
End:
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50,367,057 bp from pter |
Size:
|
93,615 bases |
Orientation:
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minus strand |
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Proteins
for KPNA3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IMA3_HUMAN, O00505 (See
protein sequence)Recommended Name: Importin subunit alpha-3 Size: 521 amino acids; 57811 Da
Subunit: Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play arole in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this interactionmight play a role in nuclear import of viral genome
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Caution: Was termed (PubMed:9395085) importin alpha-4
Secondary accessions: O00191 O43195 Q5JVM9 Q96AA7Explore the universe of human proteins at neXtProt for KPNA3: NX_O00505
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00505
KPNA3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002258.2
ENSEMBL proteins: ENSP00000261667 ENSP00000393869 Reactome Protein details: O00505
Human Recombinant Protein Products for KPNA3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KPNA3 for ontologies About GeneDecksing
KPNA3 Antibody Products:
Assay Products for KPNA3: |
Protein
Domains /
Families
for KPNA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KPNA3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00505ProtoNet protein and cluster: O00505 2 Blocks protein families: IPB000225 Armadillo repeat IPB002652 Importin alpha-like protein
UniProtKB/Swiss-Prot: IMA3_HUMAN, O00505Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a shorthydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain),which is sufficient for binding importin beta and essential for nuclear protein importDomain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internalautoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity forcytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus theinternal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity)Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs.Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of thecorresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)Similarity: Belongs to the importin alpha familySimilarity: Contains 10 ARM repeatsSimilarity: Contains 1 IBB domain |
Function
for KPNA3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IMA3_HUMAN, O00505Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex tothe nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex issubsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic sideof the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exportedfrom the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing anon-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9 Genatlas biochemistry entry for KPNA3:karyopherin alpha 3,97kDa,cytosolic,cytoplasmic face of the nuclear protein complex (NPC),homologous to yeast SRP1 andXenopus importin,putatively involved in the nuclear transport system,recognizing the nuclear localization signal ofnuclear proteins (NLS)
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
KPNA3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KPNA3 (NM_002267) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPNA3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA3 |
|
Pathways & Interactions
for KPNA3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Cytokine Signaling in Immune system | | | 4 | Immune System | | | 5 | Ran Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KPNA3
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KPNA3
1  GeneGo (Thomson Reuters) Pathway for KPNA3
1  BioSystems Pathway for KPNA3
5/6 
Reactome Pathways for KPNA3 (see all 6)
KPNA3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KPNA3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for KPNA3 (O005051, 2, 3 ENSP000002616674) via UniProtKB, MINT, STRING, and/or I2D (see all 42)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| KPNB1 | Q149742, 3, ENSP000002901584 | MINT-8078530 MINT-8078507 MINT-8078581 MINT-8078602 MINT-8078557 I2D:
score=2 STRING: ENSP00000290158 | | NFKB1 | P198382, 3, ENSP000002265744 | MINT-47908 MINT-48537 MINT-48648 I2D:
score=4 STRING: ENSP00000226574 | | CDKN1B | P465271, 3, ENSP000002288724 | EBI-358297,EBI-519280 I2D:
score=3 STRING: ENSP00000228872 | | COIL | P384322, 3, ENSP000002403164 | MINT-2860236 I2D:
score=3 STRING: ENSP00000240316 | | GRM1 | Q132552, 3, ENSP000002827534 | MINT-6803333 I2D:
score=1 STRING: ENSP00000282753 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
KPNA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KPNA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KPNA3
1 HMDB Compound for KPNA3 About this table
Search CenterWatch for drugs/clinical trials and news about KPNA3 / IMA3
|
Transcripts
for KPNA3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KPNA3 gene: NM_002267.3 Unigene Cluster for KPNA3: Karyopherin alpha 3 (importin alpha 4) Hs.527919 [show with all ESTs]Unigene Representative Sequence: NM_0022672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261667(uc001vdj.2) ENST00000436760
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KPNA3 (NM_002267) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KPNA3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA3 |
Additional cDNA sequence: AF005263.1 AF034756.1 AK223480.1 AK290528.1 AK291000.1 BC017355.2 BC024202.2 BC035090.2 D89618.1 Y12394.1 17 DOTS entries: DT.91771137 DT.100788175 DT.95175142 DT.95175164 DT.99942416 DT.120777093 DT.120777140 DT.91771134 DT.95140839 DT.100788176 DT.101982890 DT.120777101 DT.120777154 DT.120777164 DT.91771131 DT.91771138 DT.95227054 24/287 AceView cDNA sequences (see all 287): F03053 CB136661 AW439741 AA832368 BM702675 AW572476 BC017355 AI750687 AI224861 BX109056 Z39857 BM713554 CB156189 BU159838 BC024202 BM782358 AA190932 AW475054 BQ880059 AA746378 BU151437 BU145695 AA007185 AI080356
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for KPNA3
|
Expression
for KPNA3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KPNA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KPNA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KPNA3
SOURCE GeneReport for Unigene cluster: Hs.527919
UniProtKB/Swiss-Prot: IMA3_HUMAN, O00505Tissue specificity: Ubiquitous. Highest levels in heart and skeletal muscle
SABiosciences Custom PCR Arrays for KPNA3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KPNA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA3 |
Orthologs
for KPNA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KPNA3 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KPNA31 |
karyopherin alpha 3 (importin alpha 4) |
88.29(n)
98.08(a) |
|
418870 NM_001193575.1 NP_001180504.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KPNA36KPNA46 |
-- |
97(a)78(a) |
1 ↔ 1possible ortholog |
1(137553762-137583812) 5(98814482-98815299) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.35792 |
Xenopus laevis transcribed sequence with moderate similarity more |
82.98(n) |
|
BU913986.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
kpna32 |
karyopherin (importin) alpha 3 |
80.09(n) |
|
368640 AY391433.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Kap-alpha33 |
protein-nucleus import protein carrier |
67(a)
(best of 4) |
|
85D25 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
ima-33 |
importin alpha, nuclear transport factor |
61(a)
(best of 2) |
|
IV(7559979-7561848) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G328806 |
armadillo/beta-catenin-like repeats-containing pro... |
32(a) |
1 → many |
1(11913928-11914735) |
ENSEMBL Gene Tree for KPNA3 (if available)
TreeFam Gene Tree for KPNA3 (if available) |
Paralogs
for KPNA3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KPNA3 gene
- KPNA72 SPAG62 KPNA52 KPNA22 KPNA42 KPNA12 KPNA62
6 SIMAP similar genes for KPNA3 using alignment to 3 protein entries: IMA3_HUMAN (see all proteins):KPNA4 KPNA2 KPNA7 KPNA5 KPNA1 KPNA6
KPNA3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KPNA3
PGOHUM00000243691
|
Genomic Variants
for KPNA3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KPNA3 (50273443 - 50367057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KPNA3
1 CNV: 58630 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA3 |
|
Disorders
/ Diseases
for KPNA3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KPNA3 for disorders About GeneDecksing
OMIM gene information: 601892
OMIM disorders: --
7  diseases for KPNA3: About MalaCardshermaphroditism influenza ataxia schizophrenia
immunodeficiency malaria leukemia
Human Genome Epidemiology (HuGE) Navigator: KPNA3 (1 document)
Export disorders for KPNA3 gene to outside databases
|
Publications
for KPNA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KPNA3 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with KPNA3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. (PubMed id 9154134)1, 2, 3, 9 Takeda S.... Hirai Y. (1997)
- Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. (PubMed id 9435235)1, 2, 3 Nachury M.V.... Weis K. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PubMed id 12740372)1, 2 Melen K....Julkunen I. (2003)
- Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2 Kohler M....Hartmann E. (1997)
- A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. (PubMed id 16644122)1, 9 Zhang H....Shen Y. (2006)
- 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). (PubMed id 15057270)1, 9 Sekimoto T....Yoneda Y. (2004)
- The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip. (PubMed id 10744690)1, 9 Talcott B. and Moore M.S. (2000)
- Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (PubMed id 10523667)1, 9 Koehler M.... Hartmann E. (1999)
|
External Searches for KPNA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KPNA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KPNA3 gene
(According to HUGE)
About This Section
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Specialized Databases showing KPNA3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for KPNA3 gene:
Search GeneIP for patents involving KPNA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KPNA3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for KPNA3 | | OriGene shRNA RFP for KPNA3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA3 | | | OriGene Protein Over-expression Lysate for KPNA3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KPNA3 | | OriGene 3'-UTR Clone for KPNA3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KPNA3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KPNA3 | | OriGene Custom Protein Services for KPNA3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPNA3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA3 |
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| | | | Search Tocris compounds for KPNA3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA3 |
|  |  |  |  | | | | ThermoFisher Antibodies for KPNA3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA3 |
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