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Aliases for KPNA3 Gene

Aliases for KPNA3 Gene

  • Karyopherin Alpha 3 (Importin Alpha 4) 2 3
  • Karyopherin Subunit Alpha-3 3 4
  • Importin Alpha Q2 3 4
  • SRP1-Gamma 3 4
  • QIP2 3 4
  • Importin Subunit Alpha-3 3
  • Importin Subunit Alpha-4 3
  • Importin-Alpha-Q2 3
  • Importin Alpha 4 3
  • Importin Alpha-3 3
  • SRP1gamma 3
  • IPOA4 3
  • HSRP1 3
  • SRP1 3
  • SRP4 3

External Ids for KPNA3 Gene

Summaries for KPNA3 Gene

Entrez Gene Summary for KPNA3 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

GeneCards Summary for KPNA3 Gene

KPNA3 (Karyopherin Alpha 3 (Importin Alpha 4)) is a Protein Coding gene. Diseases associated with KPNA3 include opiate dependence. Among its related pathways are GPCR Pathway and Interferon Signaling. GO annotations related to this gene include protein C-terminus binding and nuclear localization sequence binding. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA3 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9

Gene Wiki entry for KPNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA3 Gene

Genomics for KPNA3 Gene

Genomic Location for KPNA3 Gene

Start:
49,699,307 bp from pter
End:
49,792,921 bp from pter
Size:
93,615 bases
Orientation:
Minus strand

Genomic View for KPNA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA3 Gene

Regulatory Elements for KPNA3 Gene

Proteins for KPNA3 Gene

  • Protein details for KPNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00505-IMA4_HUMAN
    Recommended name:
    Importin subunit alpha-4
    Protein Accession:
    O00505
    Secondary Accessions:
    • O00191
    • O43195
    • Q5JVM9
    • Q96AA7

    Protein attributes for KPNA3 Gene

    Size:
    521 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome.

neXtProt entry for KPNA3 Gene

Proteomics data for KPNA3 Gene at MOPED

Post-translational modifications for KPNA3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97 and Lys386

Other Protein References for KPNA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KPNA3 Gene

Domains for KPNA3 Gene

Gene Families for KPNA3 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • IPO :Importins

UniProtKB/Swiss-Prot:

IMA4_HUMAN
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import:
    • O00505
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).:
    • O00505
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).:
    • O00505
  • Contains 1 IBB domain.:
    • O00505
Family:
  • Belongs to the importin alpha family.:
    • O00505
Similarity:
  • Contains 10 ARM repeats.:
    • O00505
genes like me logo Genes that share domains with KPNA3: view

Function for KPNA3 Gene

Molecular function for KPNA3 Gene

GENATLAS Biochemistry: karyopherin alpha 3,97kDa,cytosolic,cytoplasmic face of the nuclear protein complex (NPC),homologous to yeast SRP1 and Xenopus importin,putatively involved in the nuclear transport system,recognizing the nuclear localization signal of nuclear proteins (NLS)
UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9

Gene Ontology (GO) - Molecular Function for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 15057270
GO:0008022 protein C-terminus binding IEA --
GO:0008139 nuclear localization sequence binding TAS 9435235
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with KPNA3: view

miRNA for KPNA3 Gene

miRTarBase miRNAs that target KPNA3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KPNA3 Gene

Localization for KPNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA3 Gene COMPARTMENTS Subcellular localization image for KPNA3 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore TAS 9154134
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA3: view

Pathways for KPNA3 Gene

genes like me logo Genes that share pathways with KPNA3: view

Pathways by source for KPNA3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KPNA3 Gene
2 Qiagen pathways for KPNA3 Gene

Gene Ontology (GO) - Biological Process for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9435235
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 9435235
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0046718 viral entry into host cell IEA --
genes like me logo Genes that share ontologies with KPNA3: view

Compounds for KPNA3 Gene

(1) HMDB Compounds for KPNA3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KPNA3: view

Transcripts for KPNA3 Gene

mRNA/cDNA for KPNA3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(287) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KPNA3 Gene

Karyopherin alpha 3 (importin alpha 4):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2:
SP3: - -

Relevant External Links for KPNA3 Gene

GeneLoc Exon Structure for
KPNA3
ECgene alternative splicing isoforms for
KPNA3

Expression for KPNA3 Gene

mRNA expression in normal human tissues for KPNA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA3 Gene

This gene is overexpressed in Muscle - Skeletal (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA3 Gene

SOURCE GeneReport for Unigene cluster for KPNA3 Gene Hs.527919

mRNA Expression by UniProt/SwissProt for KPNA3 Gene

O00505-IMA4_HUMAN
Tissue specificity: Ubiquitous. Highest levels in heart and skeletal muscle
genes like me logo Genes that share expressions with KPNA3: view

Orthologs for KPNA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KPNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA3 36
  • 99.74 (n)
  • 100 (a)
KPNA3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA3 36
  • 94.75 (n)
  • 99.23 (a)
KPNA3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA3 36
  • 94.63 (n)
  • 99.4 (a)
KPNA3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna3 36
  • 93.47 (n)
  • 99.23 (a)
Kpna3 16
Kpna3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA3 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA3 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna3 36
  • 93.09 (n)
  • 99.23 (a)
chicken
(Gallus gallus)
Aves KPNA3 36
  • 88.29 (n)
  • 98.08 (a)
KPNA3 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA3 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3579 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna3 36
  • 82.34 (n)
  • 95.39 (a)
Str.16737 36
zebrafish
(Danio rerio)
Actinopterygii kpna3 36
  • 79.62 (n)
  • 95.58 (a)
kpna3 37
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha3 37
  • 68 (a)
OneToMany
Kap-alpha3 38
  • 67 (a)
CG11040 38
  • 37 (a)
CG10478 38
  • 37 (a)
Pen 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-3 37
  • 62 (a)
OneToMany
ima-3 38
  • 61 (a)
ima-2 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 37
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11131 37
  • 68 (a)
OneToMany
Species with no ortholog for KPNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA3 Gene

ENSEMBL:
Gene Tree for KPNA3 (if available)
TreeFam:
Gene Tree for KPNA3 (if available)

Paralogs for KPNA3 Gene

Paralogs for KPNA3 Gene

Selected SIMAP similar genes for KPNA3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KPNA3 Gene

genes like me logo Genes that share paralogs with KPNA3: view

Variants for KPNA3 Gene

Sequence variations from dbSNP and Humsavar for KPNA3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3720 -- 49,699,467(+) TTTTA(A/G)ACACT utr-variant-3-prime
rs7446 -- 49,701,379(-) GTGCA(A/G)TGTGA utr-variant-3-prime
rs748678 -- 49,700,537(+) AATCA(A/G)GTTTA utr-variant-3-prime
rs755335 -- 49,701,213(-) AGTTT(A/T)AAAAA utr-variant-3-prime
rs765291 -- 49,771,517(+) gtggc(A/G)caatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA3 Gene

Variant ID Type Subtype PubMed ID
nsv900071 CNV Gain 21882294
dgv1586n71 CNV Loss 21882294
nsv819200 CNV Loss 19587683
dgv1587n71 CNV Loss 21882294
nsv510335 CNV Loss 20534489
nsv1038 CNV Loss 18451855

Relevant External Links for KPNA3 Gene

HapMap Linkage Disequilibrium report
KPNA3

Disorders for KPNA3 Gene

(1) MalaCards Diseases for KPNA3 Gene

Search for KPNA3 Gene in MalaCards »

Relevant External Links for KPNA3

Genetic Association Database (GAD)
KPNA3
Human Genome Epidemiology (HuGE) Navigator
KPNA3
genes like me logo Genes that share disorders with KPNA3: view

No data available for UniProtKB/Swiss-Prot for KPNA3 Gene

Publications for KPNA3 Gene

  1. Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. (PMID: 9154134) Takeda S. … Hirai Y. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. (PMID: 16644122) Zhang H. … Shen Y. (Neurosci. Lett. 2006) 3 23 49
  3. Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. (PMID: 9435235) Nachury M.V. … Weis K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  4. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (PMID: 10523667) Koehler M. … Hartmann E. (Mol. Cell. Biol. 1999) 3 23
  5. The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip. (PMID: 10744690) Talcott B. … Moore M.S. (J. Biol. Chem. 2000) 3 23

Products for KPNA3 Gene

  • Addgene plasmids for KPNA3

Sources for KPNA3 Gene

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