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Aliases for KPNA3 Gene

Aliases for KPNA3 Gene

  • Karyopherin Alpha 3 (Importin Alpha 4) 2 3
  • Karyopherin Subunit Alpha-3 3 4
  • Importin Alpha Q2 3 4
  • SRP1-Gamma 3 4
  • QIP2 3 4
  • Importin Subunit Alpha-3 3
  • Importin-Alpha-Q2 3
  • Importin Alpha 4 3
  • Importin Alpha-3 3
  • SRP1gamma 3
  • IPOA4 3
  • HSRP1 3
  • SRP1 3
  • SRP4 3

External Ids for KPNA3 Gene

Previous GeneCards Identifiers for KPNA3 Gene

  • GC13M048275
  • GC13M044262
  • GC13M049210
  • GC13M048071
  • GC13M049172
  • GC13M050273
  • GC13M031066

Summaries for KPNA3 Gene

Entrez Gene Summary for KPNA3 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

GeneCards Summary for KPNA3 Gene

KPNA3 (Karyopherin Alpha 3 (Importin Alpha 4)) is a Protein Coding gene. Diseases associated with KPNA3 include influenza. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA3 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9

Gene Wiki entry for KPNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA3 Gene

Genomics for KPNA3 Gene

Regulatory Elements for KPNA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KPNA3 Gene

Chromosome:
13
Start:
49,699,307 bp from pter
End:
49,792,921 bp from pter
Size:
93,615 bases
Orientation:
Minus strand

Genomic View for KPNA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA3 Gene

Proteins for KPNA3 Gene

  • Protein details for KPNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00505-IMA4_HUMAN
    Recommended name:
    Importin subunit alpha-4
    Protein Accession:
    O00505
    Secondary Accessions:
    • O00191
    • O43195
    • Q5JVM9
    • Q96AA7

    Protein attributes for KPNA3 Gene

    Size:
    521 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome.

neXtProt entry for KPNA3 Gene

Proteomics data for KPNA3 Gene at MOPED

Post-translational modifications for KPNA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KPNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KPNA3 Gene

Domains & Families for KPNA3 Gene

Gene Families for KPNA3 Gene

Suggested Antigen Peptide Sequences for KPNA3 Gene

Graphical View of Domain Structure for InterPro Entry

O00505

UniProtKB/Swiss-Prot:

IMA4_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import
  • Belongs to the importin alpha family.
  • Contains 10 ARM repeats.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA3: view

Function for KPNA3 Gene

Molecular function for KPNA3 Gene

GENATLAS Biochemistry:
karyopherin alpha 3,97kDa,cytosolic,cytoplasmic face of the nuclear protein complex (NPC),homologous to yeast SRP1 and Xenopus importin,putatively involved in the nuclear transport system,recognizing the nuclear localization signal of nuclear proteins (NLS)
UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9

Gene Ontology (GO) - Molecular Function for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 15057270
GO:0008022 protein C-terminus binding IEA --
GO:0008139 nuclear localization sequence binding TAS 9435235
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with KPNA3: view
genes like me logo Genes that share phenotypes with KPNA3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA3 Gene

Localization for KPNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA3 Gene COMPARTMENTS Subcellular localization image for KPNA3 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore TAS 9154134
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA3: view

Pathways & Interactions for KPNA3 Gene

genes like me logo Genes that share pathways with KPNA3: view

Pathways by source for KPNA3 Gene

2 Qiagen pathways for KPNA3 Gene
1 BioSystems pathway for KPNA3 Gene

SIGNOR curated interactions for KPNA3 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9435235
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 9435235
GO:0019048 modulation by virus of host morphology or physiology TAS --
GO:0019054 modulation by virus of host process TAS --
genes like me logo Genes that share ontologies with KPNA3: view

Drugs & Compounds for KPNA3 Gene

(1) Drugs for KPNA3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA3: view

Transcripts for KPNA3 Gene

mRNA/cDNA for KPNA3 Gene

Unigene Clusters for KPNA3 Gene

Karyopherin alpha 3 (importin alpha 4):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2:
SP3: - -

Relevant External Links for KPNA3 Gene

GeneLoc Exon Structure for
KPNA3
ECgene alternative splicing isoforms for
KPNA3

Expression for KPNA3 Gene

mRNA expression in normal human tissues for KPNA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA3 Gene

This gene is overexpressed in Muscle - Skeletal (x7.1).

Protein differential expression in normal tissues from HIPED for KPNA3 Gene

This gene is overexpressed in Lymph node (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA3 Gene



SOURCE GeneReport for Unigene cluster for KPNA3 Gene Hs.527919

mRNA Expression by UniProt/SwissProt for KPNA3 Gene

O00505-IMA4_HUMAN
Tissue specificity: Ubiquitous. Highest levels in heart and skeletal muscle
genes like me logo Genes that share expression patterns with KPNA3: view

Protein tissue co-expression partners for KPNA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KPNA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KPNA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KPNA3 35
  • 94.75 (n)
  • 99.23 (a)
KPNA3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA3 35
  • 94.63 (n)
  • 99.4 (a)
KPNA3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna3 35
  • 93.47 (n)
  • 99.23 (a)
Kpna3 16
Kpna3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KPNA3 35
  • 99.74 (n)
  • 100 (a)
KPNA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna3 35
  • 93.09 (n)
  • 99.23 (a)
oppossum
(Monodelphis domestica)
Mammalia KPNA3 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves KPNA3 35
  • 88.29 (n)
  • 98.08 (a)
KPNA3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna3 35
  • 82.34 (n)
  • 95.39 (a)
Str.16737 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3579 35
zebrafish
(Danio rerio)
Actinopterygii kpna3 35
  • 79.62 (n)
  • 95.58 (a)
kpna3 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10478 37
  • 37 (a)
CG11040 37
  • 37 (a)
Kap-alpha3 37
  • 67 (a)
Pen 37
  • 46 (a)
Kap-alpha3 36
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ima-2 37
  • 36 (a)
ima-3 37
  • 61 (a)
ima-3 36
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11131 36
  • 68 (a)
OneToMany
Species with no ortholog for KPNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA3 Gene

ENSEMBL:
Gene Tree for KPNA3 (if available)
TreeFam:
Gene Tree for KPNA3 (if available)

Paralogs for KPNA3 Gene

Paralogs for KPNA3 Gene

(6) SIMAP similar genes for KPNA3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KPNA3 Gene

genes like me logo Genes that share paralogs with KPNA3: view

Variants for KPNA3 Gene

Sequence variations from dbSNP and Humsavar for KPNA3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_014454 -

Structural Variations from Database of Genomic Variants (DGV) for KPNA3 Gene

Variant ID Type Subtype PubMed ID
nsv900071 CNV Gain 21882294
dgv1586n71 CNV Loss 21882294
nsv819200 CNV Loss 19587683
dgv1587n71 CNV Loss 21882294
nsv510335 CNV Loss 20534489
nsv1038 CNV Loss 18451855

Variation tolerance for KPNA3 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KPNA3 Gene

HapMap Linkage Disequilibrium report
KPNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA3 Gene

Disorders for KPNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KPNA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • influenza with non-respiratory manifestation
- elite association
Search KPNA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KPNA3

Genetic Association Database (GAD)
KPNA3
Human Genome Epidemiology (HuGE) Navigator
KPNA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA3
genes like me logo Genes that share disorders with KPNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA3 Gene

Publications for KPNA3 Gene

  1. Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. (PMID: 9154134) Takeda S. … Hirai Y. (Cytogenet. Cell Genet. 1997) 2 23 67
  2. Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding. (PMID: 19927155) Marchenko N.D. … Moll U.M. (Cell Death Differ. 2010) 23 67
  3. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PMID: 18614847) Suzuki T. … Isemura M. (Biomed. Res. 2008) 23 67
  4. Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS. (PMID: 18644123) Haenni S.S. … Hottiger M.O. (BMC Cell Biol. 2008) 23 67
  5. Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. (PMID: 18003734) Isegawa Y. … Sugimoto N. (J. Virol. 2008) 23 67

Products for KPNA3 Gene

Sources for KPNA3 Gene

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