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KPNA3 Gene

protein-coding   GIFtS: 64
GCID: GC13M050273

Karyopherin Alpha 3 (Importin Alpha 4)

  See KPNA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Karyopherin Alpha 3 (Importin Alpha 4)1 2     Importin Alpha 42
Importin Alpha Q22 3     Importin Alpha-32
Karyopherin Subunit Alpha-32 3     Importin Subunit Alpha-32
SRP1-gamma2 3     Importin Subunit Alpha-42
IPOA42     importin-alpha-Q22
SRP12     qip22
SRP1gamma2     QIP23
SRP42     Qip23
hSRP12     

External Ids:    HGNC: 63961   Entrez Gene: 38392   Ensembl: ENSG000001027537   OMIM: 6018925   UniProtKB: O005053   

Export aliases for KPNA3 gene to outside databases

Previous GC identifers: GC13M048275 GC13M044262 GC13M049210 GC13M048071 GC13M049172 GC13M031066


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KPNA3 Gene:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear
pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear
pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded
by this gene belongs to the importin alpha family, and is involved in nuclear protein import. (provided by
RefSeq, Jan 2009)

GeneCards Summary for KPNA3 Gene:
KPNA3 (karyopherin alpha 3 (importin alpha 4)) is a protein-coding gene. Diseases associated with KPNA3 include opiate dependence. GO annotations related to this gene include protein C-terminus binding and nuclear localization sequence binding. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA4_HUMAN, O00505
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein
probably through ARM repeats 7-9

Gene Wiki entry for KPNA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the KPNA3 gene promoter:
         RFX1   p53   Brachyury   Nkx2-2   RREB-1   C/EBPalpha   CHOP-10   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA3 promoter sequence
   Search Chromatin IP Primers for KPNA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KPNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.3

KPNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M050273:  view genomic region     (about GC identifiers)

Start:
50,273,443 bp from pter      End:
50,367,057 bp from pter
Size:
93,615 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMA4_HUMAN, O00505 (See protein sequence)
Recommended Name: Importin subunit alpha-4  
Size: 521 amino acids; 57811 Da
Subunit: Forms a complex with importin subunit beta-1. Interacts with HIV-1 integrase; this interaction might play
a role in nuclear import of HIV pre-integration complex. Interacts with influenza virus nucleoprotein; this
interaction might play a role in nuclear import of viral genome
Caution: Was termed (PubMed:9395085) importin alpha-4
Secondary accessions: O00191 O43195 Q5JVM9 Q96AA7

Explore the universe of human proteins at neXtProt for KPNA3: NX_O00505

Explore proteomics data for KPNA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys386
  • Modification sites at PhosphoSitePlus

  • See KPNA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002258.2  
    ENSEMBL proteins: 
     ENSP00000261667   ENSP00000393869  
    Reactome Protein details: O00505

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O00505

    ProtoNet protein and cluster: O00505

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA4_HUMAN, O00505
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Find genes that share domains with KPNA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA4_HUMAN, O00505
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein
    probably through ARM repeats 7-9

         Genatlas biochemistry entry for KPNA3:
    karyopherin alpha 3,97kDa,cytosolic,cytoplasmic face of the nuclear protein complex (NPC),homologous to yeast SRP1
    and Xenopus importin,putatively involved in the nuclear transport system,recognizing the nuclear localization
    signal of nuclear proteins (NLS)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15057270
    GO:0008022protein C-terminus binding IEA--
    GO:0008139nuclear localization sequence binding TAS9435235
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with KPNA3           About GenesLikeMe


    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate KPNA3 (see all 140):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-134 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidKPNA3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KPNA3

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    Addgene plasmids for KPNA3 

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    eBioscience FlowRNA Probe Sets ( VA1-13184) for KPNA3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMA4_HUMAN, O00505: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005643nuclear pore TAS9154134
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with KPNA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KPNA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2GPCR Pathway
    NFAT in Immune Response0.58
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4Ran Pathway
    Ran Pathway
    5Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation


    Find genes that share SuperPaths with KPNA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KPNA3
        Ran Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA3
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA3
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for KPNA3
        ISG15 antiviral mechanism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KPNA3
    Interactions:

        GeneGlobe Interaction Network for KPNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KPNA3 (O005051, 2, 3 ENSP000002616674) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Mkl1Q8K4J61, 2EBI-358297,EBI-8291665 MINT-8078581 MINT-8078602 MINT-8078702 MINT-8078530 MINT-8078682 MINT-8078507 MINT-8078652 MINT-8078624 MINT-8078557
    KPNB1Q149742, 3, ENSP000002901584MINT-8078530 MINT-8078507 MINT-8078581 MINT-8078602 MINT-8078557 I2D: score=2 STRING: ENSP00000290158
    NFKB1P198382, 3, ENSP000002265744MINT-47908 MINT-48537 MINT-48648 I2D: score=4 STRING: ENSP00000226574
    CDKN1BP465271, 3, ENSP000002288724EBI-358297,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    COILP384322, 3, ENSP000002403164MINT-2860236 I2D: score=3 STRING: ENSP00000240316
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9435235
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing protein import into nucleus TAS9435235
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0019221cytokine-mediated signaling pathway TAS--

    Find genes that share ontologies with KPNA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for KPNA3 (IMA4)

    1 HMDB Compound for KPNA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KPNA3 gene: 
    NM_002267.3  

    Unigene Cluster for KPNA3:

    Karyopherin alpha 3 (importin alpha 4)
    Hs.527919  [show with all ESTs]
    Unigene Representative Sequence: NM_002267
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261667(uc001vdj.2) ENST00000436760
    miRNA
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    hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-134 hsa-miR-519a hsa-miR-4275
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    Additional mRNA sequence: 

    AF005263.1 AF034756.1 AK223480.1 AK290528.1 AK291000.1 BC017355.2 BC024202.2 BC035090.2 
    D89618.1 Y12394.1 

    17 DOTS entries:

    DT.91771137  DT.100788175  DT.95175142  DT.95175164  DT.99942416  DT.120777093  DT.120777140  DT.91771134 
    DT.95140839  DT.100788176  DT.101982890  DT.120777101  DT.120777154  DT.120777164  DT.91771131  DT.91771138 
    DT.95227054 

    Selected AceView cDNA sequences (see all 287):

    BQ880059 AA319907 AA431116 F03053 AU130134 BP351282 AL039712 BM782358 
    AW439741 AI224861 BM713554 F09581 AI239998 AA425350 AI086282 BM969225 
    BC024202 Z39857 CB156189 BQ691861 AW192832 BM799408 AI962390 AI750687 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                              -                                                         
    SP2:                                                                                                                        
    SP3:                                                                                            -     -                     


    ECgene alternative splicing isoforms for KPNA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KPNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KPNA3 Expression
    About this image


    KPNA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    KPNA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KPNA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527919

    UniProtKB/Swiss-Prot: IMA4_HUMAN, O00505
    Tissue specificity: Ubiquitous. Highest levels in heart and skeletal muscle

        Custom PCR Arrays for KPNA3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KPNA3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kpna31 , 5 karyopherin (importin) alpha 31, 5 93.47(n)1
    99.23(a)1
      14 (32.76 cM)5
    166481  NM_008466.51  NP_032492.11 
     613651865 
    chicken
    (Gallus gallus)
    Aves KPNA31 karyopherin alpha 3 (importin alpha 4) 88.29(n)
    98.08(a)
      418870  NM_001193575.1  NP_001180504.1 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA36
    karyopherin alpha 3 (importin alpha 4)
    87(a)
    1 ↔ 1
    1(137538971-137584476)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35792 Xenopus laevis transcribed sequence with moderate similarity more 82.98(n)    BU913986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kpna32 karyopherin (importin) alpha 3 80.09(n)   368640  AY391433.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha33 protein-nucleus import protein carrier 67(a)
    (best of 4)
      85D25   --
    worm
    (Caenorhabditis elegans)
    Secernentea ima-33 importin alpha, nuclear transport
    factor
    61(a)
    (best of 2)
      IV(7559979-7561848)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP16
    Karyopherin alpha homolog, forms a dimer with kary...
    44(a)
    1 → many
    XIV(284260-285888) YNL189W


    ENSEMBL Gene Tree for KPNA3 (if available)
    TreeFam Gene Tree for KPNA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KPNA3 gene
    KPNA72  SPAG62  KPNA52  KPNA22  KPNA42  KPNA62  KPNA12  
    6 SIMAP similar genes for KPNA3 using alignment to 3 protein entries:     IMA4_HUMAN (see all proteins):
    KPNA4    KPNA2    KPNA7    KPNA5    KPNA1    KPNA6

    Find genes that share paralogs with KPNA3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KPNA3
    PGOHUM00000243691


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KPNA3 (see all 1821)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125847071,2
    C,F,H--50273171(+) aagttG/Aggtct 1 -- ds50016Minor allele frequency- A:0.03NA WA EA 364
    rs1158884771,2
    C,F--50273238(+) TCCTTT/CTTCCT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs731926831,2
    C,F--50273356(+) TAATTC/TATGAT 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs37201,2
    C,F,A--50273603(+) TTTTAA/GACACT 1 -- ut311Minor allele frequency- G:0.23MN 184
    rs10437291,2
    C,F,A,H--50273831(+) ATGTGT/CGCAAA 1 -- ut31 ese315Minor allele frequency- C:0.45NS MN EA NA WA 2174
    rs170733141,2
    C,F,H--50273833(-) AATTTG/ACACAC 1 -- ut318Minor allele frequency- A:0.02MN NS NA 1244
    rs1415230871,2
    C--50273942(+) TTCACC/TGNNNN 1 -- ut310--------
    rs18191911,2
    C,F,A,H--50273970(+) TTTTAC/TGTTGT 1 -- ut31 ese313Minor allele frequency- T:0.49NS EA NA WA 1998
    rs1403856061,2
    C--50274002(+) CCACAC/TAGTTT 1 -- ut310--------
    rs1427675101,2
    C--50274281(+) CAAGAC/GAAAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KPNA3 (50273443 - 50367057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KPNA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1587n71CNV Loss21882294
    nsv510335CNV Loss20534489
    nsv819200CNV Loss19587683
    dgv1586n71CNV Loss21882294
    nsv1038CNV Loss18451855
    nsv900071CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA3
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601892    OMIM disorders: --

    1 disease for KPNA3:    
    About MalaCards
    opiate dependence


    Find genes that share disorders with KPNA3           About GenesLikeMe

    Genetic Association Database (GAD): KPNA3
    Human Genome Epidemiology (HuGE) Navigator: KPNA3 (1 document)

    Export disorders for KPNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KPNA3 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with KPNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. (PubMed id 9154134)1, 2, 3, 9 Takeda S.... Hirai Y. (Cytogenet. Cell Genet. 1997)
    2. Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. (PubMed id 9435235)1, 2, 3 Nachury M.V.... Weis K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. (PubMed id 16644122)1, 4, 9 Zhang H....Shen Y. (Neurosci. Lett. 2006)
    4. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1, 4 Stolk L....Lunetta K.L. (Nat. Genet. 2012)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PubMed id 12740372)1, 2 Melen K....Julkunen I. (J. Biol. Chem. 2003)
    8. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PubMed id 9395085)1, 2 Koehler M.... Hartmann E. (FEBS Lett. 1997)
    9. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). (PubMed id 15057270)1, 9 Sekimoto T....Yoneda Y. (EMBO J. 2004)
    10. The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip. (PubMed id 10744690)1, 9 Talcott B. and Moore M.S. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3839 HGNC: 6396 AceView: KPNA3 Ensembl:ENSG00000102753 euGenes: HUgn3839
    ECgene: KPNA3 H-InvDB: KPNA3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KPNA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KPNA3 gene:
    Search GeneIP for patents involving KPNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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