Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KPNA2 Gene

protein-coding   GIFtS: 67
GCID: GC17P066031

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)


(Previous symbol: RCH1)
 Explore 25 diseases affiliated with
KPNA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KPNA2    

Aliases
for KPNA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Karyopherin Alpha 2 (RAG Cohort 1, Importin Alpha 1)1 2     Importin Alpha 12
RCH11 2 3 5     Importin Alpha 22
QIP21 2 5     Importin Subunit Alpha-22
IPOA11 2     Importin-Alpha-P11
SRP1alpha1 2     Pendulin1
Karyopherin Subunit Alpha-22 3     RAG Cohort 12
SRP1-Alpha1     SRP13
RAG Cohort Protein 12 3     

External Ids:    HGNC: 63951   Entrez Gene: 38382   Ensembl: ENSG000001824817   OMIM: 6006855   UniProtKB: P522923   

Export aliases for KPNA2 gene to outside databases

Previous GC identifers: GC17U990047 GC17P066449 GC17P066581 GC17M9N0103 GC17P063463 GC17P061416


Summaries
for KPNA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KPNA2:
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent
docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear
pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short
region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step
of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast
homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces
cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and
may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IMA2_HUMAN, P52292
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and
directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to
the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported
from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear
import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus

Gene Wiki entry for KPNA2 (Karyopherin alpha 2)


Genomic Views
for KPNA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KPNA2 gene promoter:
         SRF   HOXA9B   HOXA9   AML1a   Evi-1   STAT3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KPNA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KPNA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

KPNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P066031:  view genomic region     (about GC identifiers)

Start:
 66,031,635 bp from pter      End:
 66,042,970 bp from pter
Size:
 11,336 bases      Orientation:
 plus strand

Proteins
for KPNA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IMA2_HUMAN, P52292 (See protein sequence)
Recommended Name: Importin subunit alpha-2  
Size: 529 amino acids; 57862 Da
Subunit: Heterodimer; with KPNB1. Interacts with ANP32E (By similarity). Component of a complex containing CSE1L, RAN
and KPNA2. Interacts directly with CSE1L. Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus).
Interacts with ARL4A, CTNNBL1 and NBN. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers)
Subcellular location: Cytoplasm. Nucleus
Mass spectrometry: Mass=57861.92; Method=MALDI; Range=1-529; Source=PubMed:11840567;
5 PDB 3D structures from and Proteopedia for KPNA2:
1EFX (3D)        1QGK (3D)        1QGR (3D)        3FEX (3D)        3FEY (3D)    
Secondary accessions: B9EJD6 Q53YE3 Q9BRU5

Explore the universe of human proteins at neXtProt for KPNA2: NX_P52292

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52292

    • KPNA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002257.1  
    ENSEMBL proteins: 
     ENSP00000332455   ENSP00000463320   ENSP00000463602   ENSP00000438483   ENSP00000462331  
    Reactome Protein details: P52292
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: KPNA2
    OriGene Protein Over-expression Lysate: KPNA2
    OriGene Custom Protein Services for KPNA2 
    GenScript Custom Purified and Recombinant Proteins Services for KPNA2
    Novus Biologicals KPNA2 Proteins
    Novus Biologicals KPNA2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for KPNA2
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9020106
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS7754385
    GO:0005829cytosol TAS--


    KPNA2 for ontologies           About GeneDecksing



    KPNA2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KPNA2
    OriGene Antibodies (see all 2): KPNA2
    OriGene Custom Antibody Services for KPNA2 
    GenScript Custom Superior Antibodies Services for KPNA2
    Novus Biologicals KPNA2 Antibodies
    Abcam antibodies for KPNA2 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for KPNA2

    Assay Products for KPNA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KPNA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for KPNA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KPNA2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52292

    ProtoNet protein and cluster: P52292

    2 Blocks protein families:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA2_HUMAN, P52292
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short
    hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain),
    which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal
    autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for
    cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the
    internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs.
    Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the
    corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Function
    for KPNA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IMA2_HUMAN, P52292
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and
    directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to
    the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is
    subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
    of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported
    from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear
    import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
    cytoplasm and nucleus

         Genatlas biochemistry entry for KPNA2:
    karyopherin (importin) alpha 2,56kDa,component of the nuclear protein complex (NPC),yeast SRP1 and Xenopus importin
    homolog,involved in the nuclear transport system,recognizing the nuclear localization signal of nuclear proteins (NLS)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KPNA2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA2 (see all 25):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-485-3p hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: KPNA2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA2 (see all 7)
    OriGene shRNA RFP: KPNA2
    OriGene siRNA: KPNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KPNA2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KPNA2 (NM_002266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KPNA2
    Search LifeMap BioReagents cell lines for KPNA2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008139nuclear localization sequence binding IDA17324944
    GO:0008565protein transporter activity IEA--
    GO:0042826histone deacetylase binding IPI10869435


    KPNA2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KPNA2:
     Decreased viability with cispl 


    Pathways & Interactions
    for KPNA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus1.00
    		ISG15 antiviral mechanism0.49
    		Antiviral mechanism by IFN-stimulated genes0.49
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4Immune System
    		Immune System1.00
    5Ran Pathway
    		Ran Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KPNA2
        Cell cycle Spindle assembly and chromosome separation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KPNA2
        Ran Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA2
        Cell cycle Spindle assembly and chromosome separation

    4 BioSystems Pathways for KPNA2 
        TNF-alpha/NF-kB Signaling Pathway
    Signaling events mediated by TCPTP
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling

    5/6        Reactome Pathways for KPNA2 (see all 6)
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Interferon Signaling
    Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    ISG15 antiviral mechanism


    1         Kegg Pathway  (Kegg details for KPNA2):
        Influenza A


    KPNA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KPNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/883 Interacting proteins for KPNA2 (P522921, 2, 3 ENSP000003324554) via UniProtKB, MINT, STRING, and/or I2D (see all 883)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A6P067032, 3, ENSP000003577084MINT-8044928 MINT-8045257 MINT-8044941 I2D: score=1 STRING: ENSP00000357708
    SUN2Q9UH992, 3, ENSP000002160644MINT-7993400 MINT-7993425 MINT-7993447 I2D: score=1 STRING: ENSP00000216064
    RELBQ012012, 3, ENSP000002214524MINT-48015 MINT-48975 I2D: score=4 STRING: ENSP00000221452
    RECQLP460632, 3, ENSP000003954494MINT-6733215 MINT-6733231 I2D: score=3 STRING: ENSP00000395449
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000018regulation of DNA recombination TAS8016130
    GO:0000072M phase specific microtubule process TAS7565597
    GO:0000085G2 phase of mitotic cell cycle TAS7565597
    GO:0006259DNA metabolic process TAS9168958
    GO:0006607NLS-bearing substrate import into nucleus IDA17324944


    KPNA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KPNA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KPNA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KPNA2

    1 HMDB Compound for KPNA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    1 Novoseek chemical compound relationship for KPNA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 0 1 8052633 (1)

    Search CenterWatch for drugs/clinical trials and news about KPNA2 / IMA2 

    Transcripts
    for KPNA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KPNA2 gene: 
    NM_002266.2  

    Unigene Cluster for KPNA2:

    Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
    Hs.594238  [show with all ESTs]
    Unigene Representative Sequence: BC067848
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330459(uc002jgk.3) ENST00000583269 ENST00000584026 ENST00000537025(uc002jgl.3)
    ENST00000579754 ENST00000583392 ENST00000582898

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KPNA2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA2 (see all 25):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-485-3p hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: KPNA2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA2 (see all 7)
    OriGene shRNA RFP: KPNA2
    OriGene siRNA: KPNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KPNA2 (NM_002266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KPNA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA2

    Additional cDNA sequence: 

    AK024833.1 AK058111.1 AK291954.1 BC005978.1 BC013257.1 BC034443.1 BC053343.1 BC067848.1 
    BC146905.1 BT006665.1 U09559.1 U28386.1 

    24/41 DOTS entries (see all 41):

    DT.95277689  DT.100682695  DT.100682698  DT.40106295  DT.97861269  DT.95277695  DT.100682699  DT.95277687 
    DT.95277682  DT.120910040  DT.100701604  DT.95277684  DT.100682697  DT.100637685  DT.100774954  DT.102845429 
    DT.120903735  DT.87077745  DT.91788427  DT.95202463  DT.95277694  DT.95277698  DT.100682686  DT.120909785 

    24/957 AceView cDNA sequences (see all 957):

    BM450142 BM767380 BE409321 AA974509 BM471033 BQ439786 BG468240 AU141060 
    AL552749 CB124275 CA415826 CB111055 BM744436 BU944566 BU542957 AI940046 
    CB111048 CB132472 BM783931 AW327848 CB122924 BQ070648 BM770670 BE905207 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                          -           -                                                                                                           -         
    SP2:                                      -                                                                                                           -         
    SP3:                          -           -     -                                                                                                               
    SP4:                                      -                                         -     -                                                                     
    SP5:                          -           -                                               -     -                                                               

    ExUns: 15a · 15b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KPNA2

    Expression
    for KPNA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KPNA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCTGAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KPNA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    OvaryAntral FollicleOvary
    OvaryPrimary FollicleOvary
    OvaryPrimordial FollicleOvary
    OvarySecondary FollicleOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KPNA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KPNA2

    SOURCE GeneReport for Unigene cluster: Hs.594238

    UniProtKB/Swiss-Prot: IMA2_HUMAN, P52292
    Tissue specificity: Expressed ubiquitously

        SABiosciences Expression via Pathway-Focused PCR Array including KPNA2: 
              Cell Cycle in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KPNA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA2

    Orthologs
    for KPNA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA2 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KPNA21 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 77.27(n)
    83.52(a)    		   417420  NM_001006209.1  NP_001006209.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KPNA26
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343250.1(1116687-1125650)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kpna2-prov2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 75.38(n)    BC043778.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hmzeh03892 hmzeh0389 73.78(n)   321393  CA975523.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pen1 , 3 cytoplasmic transport protein carrier3
    Pendulin1    		 50(a)3
    54.47(n)1
    51.66(a)1    		   31A23
    343381  NM_057693.41  NP_477041.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ima-23 importin alpha, nuclear transport factor 37(a)   I(6323312-6325134)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G328806
    		 armadillo/beta-catenin-like repeats-containing pro...
    		 33(a)
    		 1 → many
    		 1(11913928-11914735)


    ENSEMBL Gene Tree for KPNA2 (if available)
    TreeFam Gene Tree for KPNA2 (if available) 

    Paralogs
    for KPNA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KPNA2 gene
    KPNA32  KPNA72  SPAG62  KPNA52  KPNA42  KPNA12  KPNA62  
    6 SIMAP similar genes for KPNA2 using alignment to 6 protein entries:     IMA2_HUMAN (see all proteins):
    KPNA7    KPNA4    KPNA3    KPNA5    KPNA6    KPNA1

    KPNA2 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for KPNA2 (see all 7)
    PGOHUM00000248902 PGOHUM00000262962 PGOHUM00000245976 PGOHUM00000232912 PGOHUM00000233630


    Genomic Variants
    for KPNA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/277 NCBI SNPs in KPNA2 are shown (see all 277)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1451886701,2
    		--66029848(+) CAGTAC/TTTTCA 1 -- us2k10--------
    rs1476212201,2
    		--66030002(+) TGCAAA/GAATTA 1 -- us2k10--------
    rs1420297921,2
    		--66030005(+) AAAAAC/TTAGCT 1 -- us2k10--------
    rs1501234151,2
    		--66030092(+) GAGGTC/TGCAGT 1 -- us2k10--------
    rs620846791,2
    		C,F,--66030093(+) AGGTCA/GCAGTG 1 -- us2k14Minor allele frequency- G:0.20NA 10
    rs1488365321,2
    		--66030145(+) CTAGAC/TCCTGT 1 -- us2k10--------
    rs65045751,2
    		C,A,--66030234(+) TCCTAA/CCTGCA 1 -- us2k15Minor allele frequency- C:0.00NA CSA 9
    rs80767571,2
    		C,F,H,--66030309(+) CTAGGA/GCTCAC 1 -- us2k114Minor allele frequency- G:0.05NS EA NA 1982
    rs1815680641,2
    		--66030484(+) CACATG/TCTTGC 1 -- us2k10--------
    rs1838463811,2
    		--66030487(+) ATTCTG/TGCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KPNA2 (66031635 - 66042970 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KPNA2
         1 CNV: 22953

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA2
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA2

    Disorders / Diseases
    for KPNA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KPNA2 for disorders           About GeneDecksing

    OMIM gene information: 600685    OMIM disorders: --

    20/25 diseases for KPNA2 (see all 25):    About MalaCards
    nijmegen breakage syndrome    severe acute respiratory syndrome    esophageal squamous cell carcinoma    squamous cell carcinoma
    borna disease    ductal carcinoma in situ    malignant mesothelioma    breast-ovarian cancer
    epithelial ovarian cancer    ovarian cancer    huntington's disease    cervical cancer
    carcinoma    alzheimer's disease    esophagitis    cervicitis
    influenza    breast carcinoma    lung cancer    breast cancer

    1 Novoseek disease relationship for KPNA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 17899179 (2), 18561322 (2), 16818692 (2), 20393006 (1)

    Human Genome Epidemiology (HuGE) Navigator: KPNA2 (1 document)

    Export disorders for KPNA2 gene to outside databases

    Publications
    for KPNA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KPNA2 gene, integrated from 9 sources (see all 238):
    (articles sorted by number of sources associating them with KPNA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. (PubMed id 7754385)1, 2, 3 Weis K....Lamond A.I. (1995)
    2. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. (PubMed id 8016130)1, 2, 3 Cuomo C.A.... Oettinger M.A. (1994)
    3. Genomic structure of karyopherin alpha2 (KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome. (PubMed id 11735022)1, 2, 9 Doerr S.... Hansmann I. (2001)
    4. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. (PubMed id 16188882)1, 2, 9 Tseng S.-F.... Teng S.-C. (2005)
    5. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PubMed id 7604027)1, 2, 9 Moroianu J.... Radu A. (1995)
    6. CTNNBL1 is a novel nuclear localization sequence-bind ing protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K....Neuberger M. (2011)
    7. Importin alpha protein acts as a negative regulator f or Snail protein nuclear import. (PubMed id 21454664)1, 2 Sekimoto T....Yoneda Y. (2011)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). (PubMed id 15942031)1, 2 Jackson E.B....Izumi T. (2005)

    External Searches for KPNA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KPNA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3838 HGNC: 6395 AceView: KPNA2 Ensembl:ENSG00000182481 euGenes: HUgn3838
    ECgene: KPNA2 Kegg: 3838 H-InvDB: KPNA2

    Other Databases showing KPNA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KPNA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KPNA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KPNA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KPNA2 gene:
    Search GeneIP for patents involving KPNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KPNA2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KPNA2 (KPNA2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for KPNA2   OriGene shRNA RFP for KPNA2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KPNA2  
     OriGene Protein Over-expression Lysate for KPNA2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KPNA2   OriGene 3'-UTR Clone for KPNA2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for KPNA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KPNA2   OriGene Custom Protein Services for KPNA2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KPNA2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KPNA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KPNA2
     GenScript Custom Purified and Recombinant Proteins Services for KPNA2 GenScript cDNA clones with any tag delivered in your preferred vector for KPNA2
     GenScript Custom Assay Services for KPNA2 GenScript Custom Superior Antibodies Services for KPNA2
     GenScript Custom overexpressing Cell Line Services for KPNA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KPNA2 promoter
     Search Chromatin IP Primers for KPNA2
     RT2 qPCR Primer Assay in human, mouse, rat KPNA2
     GNC Network for KPNA2
     SABiosciences PCR Arrays including human, mouse, rat KPNA2
     Search Tocris compounds for KPNA2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KPNA2 antibodies
     KPNA2 proteins
     KPNA2 lysates
     Antibodies for KPNA2
     See all of Abcam's Antibodies, Kits and Proteins for KPNA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KPNA2




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for KPNA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA2
     SwitchGear 3'UTR luciferase reporter plasmids for KPNA2
     SwitchGear Promoter luciferase reporter plasmids for KPNA2
     ThermoFisher Antibodies for KPNA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KPNA2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4