Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KPNA2 Gene

Aliases for KPNA2 Gene

  • Karyopherin Subunit Alpha 2 2 3
  • Karyopherin Alpha 2 (RAG Cohort 1, Importin Alpha 1) 2 3 5
  • Karyopherin Subunit Alpha-2 3 4
  • RAG Cohort Protein 1 3 4
  • SRP1-Alpha 3 4
  • RCH1 3 4
  • Importin Subunit Alpha-2 3
  • Karyopherin Alpha 2 2
  • Importin-Alpha-P1 3
  • Importin Alpha 1 2
  • RAG Cohort 1 2
  • SRP1alpha 3
  • Pendulin 3
  • IPOA1 3
  • SRP1 4
  • QIP2 3

External Ids for KPNA2 Gene

Previous HGNC Symbols for KPNA2 Gene

  • RCH1

Previous GeneCards Identifiers for KPNA2 Gene

  • GC17U990047
  • GC17P066449
  • GC17P066581
  • GC17M9N0103
  • GC17P063463
  • GC17P066031
  • GC17P061416

Summaries for KPNA2 Gene

Entrez Gene Summary for KPNA2 Gene

  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for KPNA2 Gene

KPNA2 (Karyopherin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with KPNA2 include Malignant Germ Cell Tumor and Ovarian Endodermal Sinus Tumor. Among its related pathways are Infectious disease and DNA Double-Strand Break Repair. GO annotations related to this gene include poly(A) RNA binding and histone deacetylase binding. An important paralog of this gene is KPNA1.

UniProtKB/Swiss-Prot for KPNA2 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for KPNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA2 Gene

Genomics for KPNA2 Gene

Regulatory Elements for KPNA2 Gene

Enhancers for KPNA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KPNA2 on UCSC Golden Path with GeneCards custom track

Promoters for KPNA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KPNA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KPNA2 Gene

Chromosome:
17
Start:
68,035,519 bp from pter
End:
68,046,854 bp from pter
Size:
11,336 bases
Orientation:
Plus strand

Genomic View for KPNA2 Gene

Genes around KPNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA2 Gene

Proteins for KPNA2 Gene

  • Protein details for KPNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52292-IMA1_HUMAN
    Recommended name:
    Importin subunit alpha-1
    Protein Accession:
    P52292
    Secondary Accessions:
    • B9EJD6
    • Q53YE3
    • Q9BRU5

    Protein attributes for KPNA2 Gene

    Size:
    529 amino acids
    Molecular mass:
    57862 Da
    Quaternary structure:
    • Heterodimer; with KPNB1. Interacts with ANP32E (By similarity). Component of a complex containing CSE1L, RAN and KPNA2. Interacts directly with CSE1L. Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus). Interacts with FRG1 (via N-terminus). Interacts with ARL4A, CTNNBL1 and NBN. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers).

    Three dimensional structures from OCA and Proteopedia for KPNA2 Gene

neXtProt entry for KPNA2 Gene

Proteomics data for KPNA2 Gene at MOPED

Post-translational modifications for KPNA2 Gene

  • Ubiquitination at Lys 83, Lys 108, Lys 123, Lys 240, Lys 291, Lys 300, Lys 353, and Lys 486
  • Modification sites at PhosphoSitePlus

Other Protein References for KPNA2 Gene

Antibody Products

  • R&D Systems Antibodies for KPNA2 (Importin alpha 2/KPNA2)
  • Cell Signaling Technology (CST) Antibodies for KPNA2 (KPNA2)

No data available for DME Specific Peptides for KPNA2 Gene

Domains & Families for KPNA2 Gene

Gene Families for KPNA2 Gene

Graphical View of Domain Structure for InterPro Entry

P52292

UniProtKB/Swiss-Prot:

IMA1_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
  • Contains 10 ARM repeats.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA2: view

Function for KPNA2 Gene

Molecular function for KPNA2 Gene

GENATLAS Biochemistry:
karyopherin (importin) alpha 2,56kDa,component of the nuclear protein complex (NPC),yeast SRP1 and Xenopus importin homolog,involved in the nuclear transport system,recognizing the nuclear localization signal of nuclear proteins (NLS)
UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IPI 10869435
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with KPNA2: view
genes like me logo Genes that share phenotypes with KPNA2: view

Animal Model Products

miRNA for KPNA2 Gene

miRTarBase miRNAs that target KPNA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA2 Gene

Localization for KPNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA2 Gene COMPARTMENTS Subcellular localization image for KPNA2 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA2: view

Pathways & Interactions for KPNA2 Gene

genes like me logo Genes that share pathways with KPNA2: view

SIGNOR curated interactions for KPNA2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006606 protein import into nucleus IEA --
GO:0019054 modulation by virus of host process TAS --
GO:0019058 viral life cycle TAS --
GO:0075733 intracellular transport of virus TAS --
genes like me logo Genes that share ontologies with KPNA2: view

Drugs & Compounds for KPNA2 Gene

(2) Drugs for KPNA2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA2: view

Transcripts for KPNA2 Gene

Unigene Clusters for KPNA2 Gene

Karyopherin alpha 2 (RAG cohort 1, importin alpha 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - -
SP8: - -
SP9:

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for KPNA2 Gene

GeneLoc Exon Structure for
KPNA2
ECgene alternative splicing isoforms for
KPNA2

Expression for KPNA2 Gene

mRNA expression in normal human tissues for KPNA2 Gene

mRNA differential expression in normal tissues according to GTEx for KPNA2 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for KPNA2 Gene

This gene is overexpressed in Bone (26.3), Lung (16.1), Testis (11.5), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA2 Gene



SOURCE GeneReport for Unigene cluster for KPNA2 Gene Hs.594238

mRNA Expression by UniProt/SwissProt for KPNA2 Gene

P52292-IMA1_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with KPNA2: view

Protein tissue co-expression partners for KPNA2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KPNA2 Gene

Orthologs for KPNA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KPNA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KPNA2 35
  • 90.99 (n)
  • 95.27 (a)
KPNA2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA2 35
  • 93.51 (n)
  • 97.73 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
KPNA2 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kpna2 35
  • 87.59 (n)
  • 94.52 (a)
Kpna2 16
Gm10184 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KPNA2 35
  • 98.44 (n)
  • 97.72 (a)
KPNA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna2 35
  • 87.27 (n)
  • 94.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves KPNA2 35
  • 77.27 (n)
  • 83.52 (a)
KPNA2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna2 35
  • 70.41 (n)
  • 77.52 (a)
Str.6468 35
African clawed frog
(Xenopus laevis)
Amphibia kpna2-prov 35
zebrafish
(Danio rerio)
Actinopterygii hmzeh0389 35
kpna2 35
  • 68.2 (n)
  • 73.75 (a)
kpna2 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pen 37
  • 50 (a)
Pen 35
  • 54.47 (n)
  • 51.66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009792 35
  • 54.16 (n)
  • 52.61 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 37
  • 37 (a)
ima-2 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for KPNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA2 Gene

ENSEMBL:
Gene Tree for KPNA2 (if available)
TreeFam:
Gene Tree for KPNA2 (if available)

Paralogs for KPNA2 Gene

Paralogs for KPNA2 Gene

(6) SIMAP similar genes for KPNA2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KPNA2: view

Variants for KPNA2 Gene

Sequence variations from dbSNP and Humsavar for KPNA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11545989 - 68,042,276(+) CATCC(C/G)AGCAT reference, missense
VAR_014453 -
rs17850032 - 68,042,252(+) CAAGG(C/T)TGTGG reference, missense
rs1059558 - 68,044,000(+) CAGCC(A/G)GCCGC reference, missense
rs17850031 - 68,045,783(+) GAGAA(A/C)CTAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KPNA2 Gene

Variant ID Type Subtype PubMed ID
nsv436233 CNV Deletion 17901297
esv2716136 CNV Deletion 23290073
esv2716138 CNV Deletion 23290073

Variation tolerance for KPNA2 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KPNA2 Gene

Disorders for KPNA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KPNA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malignant germ cell tumor
ovarian endodermal sinus tumor
  • endodermal sinus tumor of ovary
ovarian primitive germ cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search KPNA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KPNA2

Genetic Association Database (GAD)
KPNA2
Human Genome Epidemiology (HuGE) Navigator
KPNA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KPNA2
genes like me logo Genes that share disorders with KPNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA2 Gene

Publications for KPNA2 Gene

  1. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. (PMID: 7754385) Weis K. … Lamond A.I. (Science 1995) 2 3 4 67
  2. The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. (PMID: 19961560) Sandrock K. … Klugbauer N. (Traffic 2010) 3 23
  3. Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. (PMID: 20393006) Sakai M. … Kuwano H. (Anticancer Res. 2010) 3 23
  4. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. (PMID: 19117056) van der Watt P.J. … Leaner V.D. (Int. J. Cancer 2009) 3 23
  5. Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity. (PMID: 18561322) Gluz O. … Hartmann A. (Int. J. Cancer 2008) 3 23

Products for KPNA2 Gene

Sources for KPNA2 Gene

Content