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KPNA1 Gene

protein-coding   GIFtS: 65
GCID: GC03M122140

Karyopherin Alpha 1 (Importin Alpha 5)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Karyopherin Alpha 1 (Importin Alpha 5)1 2     SRP12 5
RCH22 3 5     IPOA52
Karyopherin Subunit Alpha-12 3     Importin Alpha 52
Nucleoprotein Interactor 12 3     Importin Subunit Alpha-12
NPI-12 3     Importin Subunit Alpha-52
SRP1-beta2 3     importin-alpha-S12
RAG Cohort Protein 22 3     Recombination Activating Gene Cohort 22

External Ids:    HGNC: 63941   Entrez Gene: 38362   Ensembl: ENSG000001140307   OMIM: 6006865   UniProtKB: P522943   

Export aliases for KPNA1 gene to outside databases

Previous GC identifers: GC03M118866 GC03M122093 GC03M123425 GC03M123465 GC03M123627 GC03M119513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KPNA1 Gene:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear
pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear
pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded
by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein
interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1
ubiquitin ligase. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for KPNA1 Gene:
KPNA1 (karyopherin alpha 1 (importin alpha 5)) is a protein-coding gene. GO annotations related to this gene include protein transporter activity and nuclear localization sequence binding. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA1 (Karyopherin alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KPNA1 gene promoter:
         Max1   USF1   Evi-1   Nkx6-1   POU2F1   USF-1   POU2F1b   POU2F1a   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA1 promoter sequence
   Search Chromatin IP Primers for KPNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KPNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

KPNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122140:  view genomic region     (about GC identifiers)

Start:
122,140,748 bp from pter      End:
122,233,792 bp from pter
Size:
93,045 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for KPNA1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294 (See protein sequence)
Recommended Name: Importin subunit alpha-5  
Size: 538 amino acids; 60222 Da
Subunit: Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF;
the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required
for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with the nucleoprotein of
influenza A viruses. Binds to HCMV (human cytomegalovirus) UL84, HIV-1 Vpr and to ebolavirus VP24. Interacts with
APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with
SNAI1 (via zinc fingers)
3 PDB 3D structures from and Proteopedia for KPNA1:
2JDQ (3D)        3TJ3 (3D)        4B18 (3D)    
Secondary accessions: D3DN93 Q6IBQ9 Q9BQ56

Explore the universe of human proteins at neXtProt for KPNA1: NX_P52294

Explore proteomics data for KPNA1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in the presence of RAG1 (in vitro)1
  • Ubiquitination2 at Lys46, Lys105, Lys136, Lys356
  • Modification sites at PhosphoSitePlus

  • See KPNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002255.3  
    ENSEMBL proteins: 
     ENSP00000343701   ENSP00000420013   ENSP00000418394   ENSP00000419890   ENSP00000417166  
     ENSP00000417319   ENSP00000419257  
    Reactome Protein details: P52294

    KPNA1 Human Recombinant Protein Products:

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    Novus Biologicals KPNA1 Proteins
    Novus Biologicals KPNA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KPNA1 

     
    antibodies-online proteins for KPNA1 (5 products) 

     
    antibodies-online peptides for KPNA1

    KPNA1 Antibody Products:

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    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for KPNA1 (55 products) 

    KPNA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for KPNA1 
    antibodies-online kits for KPNA1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52294

    ProtoNet protein and cluster: P52294

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Find genes that share domains with KPNA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA5_HUMAN, P52294
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12011095
    GO:0008139nuclear localization sequence binding TAS7754385
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with KPNA1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kpna1):
     behavior/neurological  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with KPNA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kpna1tm1.2Yyo for KPNA1

       genOway: Develop your customized and physiologically relevant rodent model for KPNA1

    miRNA
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    miRTarBase miRNAs that target KPNA1:
    hsa-mir-30a-5p (MIRT028495), hsa-mir-186-5p (MIRT045073), hsa-mir-103a-3p (MIRT027097), hsa-mir-16-5p (MIRT031732), hsa-mir-34a-5p (MIRT025234)

    Block miRNA regulation of human, mouse, rat KPNA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KPNA1 (see all 215):
    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KPNA1

    Gene Editing
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    Sino Biological Human cDNA Clone for KPNA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA1
    Addgene plasmids for KPNA1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMA5_HUMAN, P52294: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005643nuclear pore TAS8052633
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with KPNA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KPNA1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Vpr-mediated nuclear import of PICs0.91
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Interactions of Vpr with host cellular proteins0.91
    3Influenza Viral RNA Transcription and Replication
    Influenza Life Cycle0.82
    Influenza Infection0.80
    4HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    5Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.00


    Find genes that share SuperPaths with KPNA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KPNA1
        Ran Pathway
    JAK-STAT Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA1
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA1
        Class I PI3K signaling events mediated by Akt


    4 Reactome Pathways for KPNA1
        Activation of DNA fragmentation factor
    Transport of Ribonucleoproteins into the Host Nucleus
    Vpr-mediated nuclear import of PICs
    ISG15 antiviral mechanism


    1 Kegg Pathway  (Kegg details for KPNA1):
        Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KPNA1
    Interactions:

        GeneGlobe Interaction Network for KPNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KPNA1 (P522941, 2, 3 ENSP000003437014) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANP32AP396872, 3, ENSP000004178644MINT-2860174 I2D: score=3 STRING: ENSP00000417864
    LMO4P619682, 3, ENSP000003595734MINT-60896 I2D: score=3 STRING: ENSP00000359573
    RELBQ012012, 3, ENSP000002214524MINT-48976 I2D: score=2 STRING: ENSP00000221452
    STAT3P407632, 3, ENSP000002646574MINT-6803345 I2D: score=2 STRING: ENSP00000264657
    BRCA1P383982, 3, ENSP000003502834MINT-14398 I2D: score=1 STRING: ENSP00000350283
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000018regulation of DNA recombination TAS8052633
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing protein import into nucleus TAS7754385
    GO:0006915apoptotic process TAS--

    Find genes that share ontologies with KPNA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KPNA1 (IMA5)

    1 HMDB Compound for KPNA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KPNA1 gene: 
    NM_002264.3  

    Unigene Cluster for KPNA1:

    Karyopherin alpha 1 (importin alpha 5)
    Hs.161008  [show with all ESTs]
    Unigene Representative Sequence: NR_026698
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344337(uc003efb.1 uc003efc.1 uc011bjr.1 uc010hrh.2 uc003efe.2)
    ENST00000470904 ENST00000466923 ENST00000485027 ENST00000494339 ENST00000465882
    ENST00000464940 ENST00000482287 ENST00000476916 ENST00000493510
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    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
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      QuantiFast Probe-based Assays in human, mouse, rat KPNA1

    Additional mRNA sequence: 

    AF035311.1 AK125626.1 AK128280.1 AK299030.1 BC002374.2 BC003009.1 BC029937.1 BC090864.1 
    BT006959.1 CR456743.1 NR_026698.1 U20620.1 

    20 DOTS entries:

    DT.102830070  DT.70103798  DT.456193  DT.95171435  DT.100795589  DT.92470132  DT.95324085  DT.100795596 
    DT.101980429  DT.318526  DT.100017910  DT.120892661  DT.95216676  DT.100648725  DT.100795600  DT.120892618 
    DT.120892688  DT.95072418  DT.120892621  DT.95171434 

    Selected AceView cDNA sequences (see all 294):

    BQ014669 AA856880 AI189712 BG287593 BM918169 F10909 BX386672 BU738827 
    AW594436 AI478482 AI721045 BX401067 AF035311 AW166743 T40356 CA433573 
    BX108372 AI688152 AW292334 BF724205 BU630184 CR620304 BQ576083 BU189316 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                -     -     -     -     -                                                                           
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                  -     -                                                                           


    ECgene alternative splicing isoforms for KPNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KPNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KPNA1 Expression
    About this image


    KPNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Kidney (Urinary System)
             Metanephros
     
     Lung (Respiratory System)
             Trachea
    KPNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KPNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.161008

    UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
    Tissue specificity: Expressed ubiquitously

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kpna11 , 5 karyopherin (importin) alpha 11, 5 92.87(n)1
    97.77(a)1
      16 (25.43 cM)5
    166461  NM_008465.51  NP_032491.21 
     359787505 
    chicken
    (Gallus gallus)
    Aves KPNA11 karyopherin alpha 1 (importin alpha 5) 82.22(n)
    95.72(a)
      418271  NM_001030774.1  NP_001025945.1 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA16
    karyopherin alpha 1 (importin alpha 5)
    79(a)
    1 ↔ 1
    GL343473.1(32012-92226)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851302.12   -- 79.1(n)    BX851302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kpna11 karyopherin alpha 1 (importin alpha 5) 74.3(n)
    85.1(a)
      572542  XM_696267.6  XP_701359.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha13 protein-nucleus import protein carrier 61(a)
    (best of 2)
      76C6   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP16
    Karyopherin alpha homolog, forms a dimer with kary...
    49(a)
    1 → many
    XIV(284260-285888) YNL189W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IMPA-41 IMPA-4 55.51(n)
    53.61(a)
      837448  NM_100797.5  NP_172398.1 
    barley
    (Hordeum vulgare)
    Liliopsida BI948483.12   -- 76.97(n)    BI948483.1 


    ENSEMBL Gene Tree for KPNA1 (if available)
    TreeFam Gene Tree for KPNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KPNA1 gene
    KPNA72  KPNA32  SPAG62  KPNA52  KPNA22  KPNA42  KPNA62  
    6 SIMAP similar genes for KPNA1 using alignment to 8 protein entries:     IMA5_HUMAN (see all proteins):
    KPNA5    KPNA6    KPNA4    KPNA3    KPNA2    KPNA7

    Find genes that share paralogs with KPNA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KPNA1 (see all 1811)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114548321,2
    C--122140260(+) TCAGC-/T/TT  
            
    TTTTT
    2 -- ds50010--------
    rs592800511,2
    C--122140426(+) CACCCA/GGCTAG 2 -- ds50010--------
    rs1915721741,2
    --122140484(+) TGGTCC/TCGATC 2 -- ds50010--------
    rs558536771,2
    C--122140616(+) GCTATG/AACAAT 2 -- ds50014Minor allele frequency- A:0.23WA NA EA 360
    rs1158749251,2
    F--122140741(+) GAATTC/GCTTTG 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1848903661,2
    --122140848(+) TCACCA/CATGGC 2 -- ut31 nc-transcript-variant0--------
    rs557816081,2
    C--122140919(+) ACACTT/CTGAAG 2 -- ut31 nc-transcript-variant4Minor allele frequency- C:0.10NA WA EA 360
    rs2006096291,2
    C--122141130(+) CCACA-/TTGTGTGC 2 -- cds1 nc-transcript-variant0--------
    rs119321,2
    C,F,O,H--122141135(+) TTGTGC/TGTTTG 2 -- ut31 nc-transcript-variant24Minor allele frequency- T:0.20MN NS EA NA WA 2948
    rs352066351,2
    C--122141192(+) TGCAC-/A/AA  
            
    AAAAA
    4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for KPNA1 (122140748 - 122233792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KPNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3974CNV Insertion18451855
    nsv877391CNV Gain21882294

    Human Gene Mutation Database (HGMD): KPNA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KPNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for KPNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600686    OMIM disorders: --


    Find genes that share disorders with KPNA1           About GenesLikeMe


    Export disorders for KPNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KPNA1 gene, integrated from 10 sources (see all 185):
    (articles sorted by number of sources associating them with KPNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. (PubMed id 8052633)1, 2, 3 Cortes P.... Baltimore D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. (PubMed id 19118899)1, 2, 9 Simkus C.... Jones J.M. (Mol. Immunol. 2009)
    3. NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. (PubMed id 7831767)1, 2, 9 O'Neill R.E. and Palese P. (Virology 1995)
    4. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PubMed id 7604027)1, 2, 9 Moroianu J.... Radu A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    5. Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). (PubMed id 15942031)1, 2, 9 Jackson E.B.... Izumi T. (Nucleic Acids Res. 2005)
    6. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K.... Neuberger M. (J. Biol. Chem. 2011)
    7. Ebola virus VP24 binds karyopherin alpha-1 and blocks STAT1 nuclear accumulation. (PubMed id 16698996)1, 2 Reid S.P.... Basler C.F. (J. Virol. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (J. Virol. 2003)
    10. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. (PubMed id 9463369)1, 2 Popov S.... Bukrinsky M. (EMBO J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3836 HGNC: 6394 AceView: KPNA1 Ensembl:ENSG00000114030 euGenes: HUgn3836
    ECgene: KPNA1 Kegg: 3836 H-InvDB: KPNA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KPNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KPNA1 gene:
    Search GeneIP for patents involving KPNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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