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Aliases for KPNA1 Gene

Aliases for KPNA1 Gene

  • Karyopherin Alpha 1 (Importin Alpha 5) 2 3
  • RCH2 3 4 6
  • Karyopherin Subunit Alpha-1 3 4
  • Nucleoprotein Interactor 1 3 4
  • RAG Cohort Protein 2 3 4
  • SRP1-Beta 3 4
  • NPI-1 3 4
  • SRP1 3 6
  • Recombination Activating Gene Cohort 2 3
  • Importin Subunit Alpha-1 3
  • Importin Subunit Alpha-5 3
  • Importin-Alpha-S1 3
  • Importin Alpha 5 3
  • IPOA5 3

External Ids for KPNA1 Gene

Previous GeneCards Identifiers for KPNA1 Gene

  • GC03M118866
  • GC03M122093
  • GC03M123425
  • GC03M123465
  • GC03M123627
  • GC03M122140
  • GC03M119513

Summaries for KPNA1 Gene

Entrez Gene Summary for KPNA1 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for KPNA1 Gene

KPNA1 (Karyopherin Alpha 1 (Importin Alpha 5)) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein transporter activity and nuclear localization sequence binding. An important paralog of this gene is KPNA6.

UniProtKB/Swiss-Prot for KPNA1 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA1 Gene

Genomics for KPNA1 Gene

Regulatory Elements for KPNA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KPNA1 Gene

Start:
122,421,901 bp from pter
End:
122,514,945 bp from pter
Size:
93,045 bases
Orientation:
Minus strand

Genomic View for KPNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KPNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA1 Gene

Proteins for KPNA1 Gene

  • Protein details for KPNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52294-IMA5_HUMAN
    Recommended name:
    Importin subunit alpha-5
    Protein Accession:
    P52294
    Secondary Accessions:
    • D3DN93
    • Q6IBQ9
    • Q9BQ56

    Protein attributes for KPNA1 Gene

    Size:
    538 amino acids
    Molecular mass:
    60222 Da
    Quaternary structure:
    • Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF; the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with the nucleoprotein of influenza A viruses. Binds to HCMV (human cytomegalovirus) UL84, HIV-1 Vpr and to ebolavirus VP24. Interacts with APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with SNAI1 (via zinc fingers). Interacts with DCAF8.

    Three dimensional structures from OCA and Proteopedia for KPNA1 Gene

neXtProt entry for KPNA1 Gene

Proteomics data for KPNA1 Gene at MOPED

Post-translational modifications for KPNA1 Gene

  • Polyubiquitinated in the presence of RAG1 (in vitro).
  • Ubiquitination at Lys46, Lys105, Lys136, and Lys356
  • Modification sites at PhosphoSitePlus

Other Protein References for KPNA1 Gene

Antibody Products

  • R&D Systems Antibodies for KPNA1 (Importin alpha 5/KPNA1)

No data available for DME Specific Peptides for KPNA1 Gene

Domains for KPNA1 Gene

Gene Families for KPNA1 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • IPO :Importins

Suggested Antigen Peptide Sequences for KPNA1 Gene

Graphical View of Domain Structure for InterPro Entry

P52294

UniProtKB/Swiss-Prot:

IMA5_HUMAN :
  • P52294
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
  • Contains 1 IBB domain.
Family:
  • Belongs to the importin alpha family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with KPNA1: view

Function for KPNA1 Gene

Molecular function for KPNA1 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Ontology (GO) - Molecular Function for KPNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12011095
GO:0008139 nuclear localization sequence binding TAS 7754385
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with KPNA1: view
genes like me logo Genes that share phenotypes with KPNA1: view

Animal Models for KPNA1 Gene

MGI Knock Outs for KPNA1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KPNA1 Gene

Localization for KPNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KPNA1 Gene COMPARTMENTS Subcellular localization image for KPNA1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for KPNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005643 nuclear pore TAS 8052633
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA1: view

Pathways for KPNA1 Gene

genes like me logo Genes that share pathways with KPNA1: view

Pathways by source for KPNA1 Gene

1 KEGG pathway for KPNA1 Gene
1 GeneGo (Thomson Reuters) pathway for KPNA1 Gene

Gene Ontology (GO) - Biological Process for KPNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000018 regulation of DNA recombination TAS 8052633
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006606 protein import into nucleus --
GO:0006607 NLS-bearing protein import into nucleus TAS 7754385
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with KPNA1: view

Compounds for KPNA1 Gene

(1) HMDB Compounds for KPNA1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KPNA1: view

Transcripts for KPNA1 Gene

Unigene Clusters for KPNA1 Gene

Karyopherin alpha 1 (importin alpha 5):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KPNA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2:
SP3:
SP4: - -

Relevant External Links for KPNA1 Gene

GeneLoc Exon Structure for
KPNA1
ECgene alternative splicing isoforms for
KPNA1

Expression for KPNA1 Gene

mRNA expression in normal human tissues for KPNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KPNA1 Gene

This gene is overexpressed in Muscle - Skeletal (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KPNA1 Gene

SOURCE GeneReport for Unigene cluster for KPNA1 Gene Hs.161008

mRNA Expression by UniProt/SwissProt for KPNA1 Gene

P52294-IMA5_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with KPNA1: view

In Situ Assay Products

Orthologs for KPNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA1 35
  • 99.75 (n)
  • 99.81 (a)
KPNA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA1 35
  • 95.29 (n)
  • 99.26 (a)
KPNA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA1 35
  • 95.23 (n)
  • 99.44 (a)
KPNA1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kpna1 35
  • 92.87 (n)
  • 97.77 (a)
Kpna1 16
Kpna1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kpna1 35
  • 92.75 (n)
  • 98.33 (a)
chicken
(Gallus gallus)
Aves KPNA1 35
  • 82.22 (n)
  • 95.72 (a)
KPNA1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna1 35
  • 79.74 (n)
  • 94.05 (a)
zebrafish
(Danio rerio)
Actinopterygii kpna1 35
  • 74.3 (n)
  • 85.1 (a)
kpna1 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 36
  • 61 (a)
OneToMany
Kap-alpha1 37
  • 61 (a)
Pen 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 36
  • 49 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons IMPA-4 35
  • 55.51 (n)
  • 53.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KPNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA1 Gene

ENSEMBL:
Gene Tree for KPNA1 (if available)
TreeFam:
Gene Tree for KPNA1 (if available)

Paralogs for KPNA1 Gene

Paralogs for KPNA1 Gene

Selected SIMAP similar genes for KPNA1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with KPNA1: view

Variants for KPNA1 Gene

Sequence variations from dbSNP and Humsavar for KPNA1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1133935 -- 122,513,369(-) TCTTG(A/G)AAGAC intron-variant
rs1135417 -- 122,457,555(-) AATTA(A/C)AGTTT intron-variant
rs3749209 -- 122,449,494(-) TTAAT(G/T)GATTG intron-variant
rs4413264 -- 122,445,004(+) ccaaa(A/G)gatcg intron-variant
rs4434100 -- 122,473,425(+) tataa(C/G)aaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA1 Gene

Variant ID Type Subtype PubMed ID
nsv3974 CNV Insertion 18451855
nsv877391 CNV Gain 21882294

Relevant External Links for KPNA1 Gene

HapMap Linkage Disequilibrium report
KPNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA1 Gene

Disorders for KPNA1 Gene

No disorders were found for KPNA1 Gene.

No data available for UniProtKB/Swiss-Prot for KPNA1 Gene

Publications for KPNA1 Gene

  1. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PMID: 7604027) Moroianu J. … Radu A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. (PMID: 7831767) O'Neill R.E. … Palese P. (Virology 1995) 3 4 23
  3. Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). (PMID: 15942031) Jackson E.B. … Izumi T. (Nucleic Acids Res. 2005) 3 4 23
  4. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. (PMID: 19118899) Simkus C. … Jones J.M. (Mol. Immunol. 2009) 3 4 23
  5. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. (PMID: 8052633) Cortes P. … Baltimore D. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4

Products for KPNA1 Gene

  • Addgene plasmids for KPNA1

Sources for KPNA1 Gene

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