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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KPNA1 Gene

protein-coding   GIFtS: 62
GCID: GC03M122140

karyopherin alpha 1 (importin alpha 5)
 Explore 9 diseases affiliated with
KPNA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KPNA1    

Aliases
for KPNA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Karyopherin Alpha 1 (Importin Alpha 5)1 2     SRP1-Beta1
RCH21 2 3 5     RAG Cohort Protein 22 3
NPI-11 2 3     Importin Alpha 52
SRP11 2 5     Importin Subunit Alpha-12
IPOA51 2     Importin-Alpha-S11
Karyopherin Subunit Alpha-12 3     Recombination Activating Gene Cohort 22
Nucleoprotein Interactor 12 3     

External Ids:    HGNC: 63941   Entrez Gene: 38362   Ensembl: ENSG000001140307   OMIM: 6006865   UniProtKB: P522943   
ORGUL members:         
NONCODE:n339470 n407230    

Export aliases for KPNA1 gene to outside databases

Previous GC identifers: GC03M118866 GC03M122093 GC03M123425 GC03M123465 GC03M123627 GC03M119513


Summaries
for KPNA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KPNA1:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore
complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by
nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene
belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the
recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: IMA1_HUMAN, P52294
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and
directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to
the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported
from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear
import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a
non-classical NLS

Gene Wiki entry for KPNA1 (Karyopherin alpha 1)


Genomic Views
for KPNA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KPNA1 gene promoter:
         Max1   USF1   Evi-1   Nkx6-1   POU2F1   USF-1   POU2F1b   POU2F1a   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KPNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KPNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

KPNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122140:  view genomic region     (about GC identifiers)

Start:
 122,140,748 bp from pter      End:
 122,233,792 bp from pter
Size:
 93,045 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n407230
  • n339470
122140747 122187267 122233786 chr3

Proteins
for KPNA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IMA1_HUMAN, P52294 (See protein sequence)
Recommended Name: Importin subunit alpha-1  
Size: 538 amino acids; 60222 Da
Subunit: Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF; the
interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for
nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with the nucleoprotein of influenza A
viruses. Binds to HCMV (human cytomegalovirus) UL84, HIV-1 Vpr and to ebolavirus VP24. Interacts with APEX1 and RAG1.
Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with SNAI1 (via zinc
fingers)
Subcellular location: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for KPNA1:
2JDQ (3D)        3TJ3 (3D)    
Secondary accessions: D3DN93 Q6IBQ9 Q9BQ56

Explore the universe of human proteins at neXtProt for KPNA1: NX_P52294

Post-translational modifications:

  • Polyubiquitinated in the presence of RAG1 (in vitro)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52294

    • KPNA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002255.3  
    ENSEMBL proteins: 
     ENSP00000343701   ENSP00000420013   ENSP00000418394   ENSP00000419890   ENSP00000417166  
     ENSP00000417319   ENSP00000419257  
    Reactome Protein details: P52294
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: KPNA1
    Browse OriGene Protein Over-expression Lysates
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    GenScript Custom Purified and Recombinant Proteins Services for KPNA1
    Novus Biologicals KPNA1 Proteins
    Novus Biologicals KPNA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005643nuclear pore TAS8052633
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS7754385
    GO:0005829cytosol TAS--


    KPNA1 for ontologies           About GeneDecksing



    KPNA1 Antibody Products: 
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    Novus Biologicals KPNA1 Antibodies
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    Browse Antibodies at Uscn
    ThermoFisher Antibodies for KPNA1

    Assay Products for KPNA1: 
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    GenScript Custom Assay Services for KPNA1
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for KPNA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KPNA1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52294

    ProtoNet protein and cluster: P52294

    2 Blocks protein families:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA1_HUMAN, P52294
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short
    hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain),
    which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal
    autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for
    cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the
    internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs.
    Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the
    corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    Function
    for KPNA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IMA1_HUMAN, P52294
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and
    directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to
    the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is
    subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
    of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported
    from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear
    import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
    cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a
    non-classical NLS

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KPNA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA1
    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA1 (see all 215):
    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA1 (see all 7)
    OriGene shRNA RFP: KPNA1
    OriGene siRNA: KPNA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KPNA1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KPNA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KPNA1 (NM_002264)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for KPNA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12011095
    GO:0008139nuclear localization sequence binding TAS7754385
    GO:0008565protein transporter activity IEA--


    KPNA1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Kpna1tm1.2Yyo for KPNA1
         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kpna1):
     behavior/neurological  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    KPNA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KPNA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus1.00
    		Antiviral mechanism by IFN-stimulated genes0.49
    		Vpr-mediated nuclear import of PICs0.76
    		ISG15 antiviral mechanism0.49
    		Interactions of Vpr with host cellular proteins0.70
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64
    5Activation of DNA fragmentation factor
    		Activation of DNA fragmentation factor1.00
    		Apoptosis induced DNA fragmentation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KPNA1
        Cell cycle Spindle assembly and chromosome separation

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KPNA1
        Ran Pathway
    JAK-STAT Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA1
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA1 
        Class I PI3K signaling events mediated by Akt

    5/18        Reactome Pathways for KPNA1 (see all 18)
        Activation of DNA fragmentation factor
    Antiviral mechanism by IFN-stimulated genes
    Transport of Ribonucleoproteins into the Host Nucleus
    Apoptosis
    Disease


    1         Kegg Pathway  (Kegg details for KPNA1):
        Influenza A


    KPNA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KPNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/642 Interacting proteins for KPNA1 (P522942, 3 ENSP000003437014) via UniProtKB, MINT, STRING, and/or I2D (see all 642)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANP32AP396872, 3, ENSP000004178644MINT-2860174 I2D: score=3 STRING: ENSP00000417864
    LMO4P619682, 3, ENSP000003595734MINT-60896 I2D: score=3 STRING: ENSP00000359573
    RELBQ012012, 3, ENSP000002214524MINT-48976 I2D: score=2 STRING: ENSP00000221452
    STAT3P407632, 3, ENSP000002646574MINT-6803345 I2D: score=2 STRING: ENSP00000264657
    BRCA1P383982, 3, ENSP000003502834MINT-14398 I2D: score=1 STRING: ENSP00000350283
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000018regulation of DNA recombination TAS8052633
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing substrate import into nucleus TAS7754385
    GO:0006915apoptotic process TAS--


    KPNA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KPNA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KPNA1

    1 HMDB Compound for KPNA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about KPNA1 / IMA1 

    Transcripts
    for KPNA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KPNA1 gene: 
    NM_002264.3  

    Unigene Cluster for KPNA1:

    Karyopherin alpha 1 (importin alpha 5)
    Hs.161008  [show with all ESTs]
    Unigene Representative Sequence: NR_026698
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344337(uc003efb.1 uc003efc.1 uc011bjr.1 uc010hrh.2 uc003efe.2)
    ENST00000470904 ENST00000466923 ENST00000485027 ENST00000494339 ENST00000465882
    ENST00000464940 ENST00000482287 ENST00000476916 ENST00000493510

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA1
    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA1 (see all 215):
    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KPNA1 (see all 7)
    OriGene shRNA RFP: KPNA1
    OriGene siRNA: KPNA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA1
    Clone
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    GenScript: all cDNA clones in your preferred vector: KPNA1 (NM_002264)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA1

    Additional cDNA sequence: 

    AF035311.1 AK125626.1 AK128280.1 AK299030.1 BC002374.2 BC003009.1 BC029937.1 BC090864.1 
    BT006959.1 CR456743.1 NR_026698.1 U20620.1 

    20 DOTS entries:

    DT.102830070  DT.70103798  DT.456193  DT.95171435  DT.100795589  DT.92470132  DT.95324085  DT.100795596 
    DT.101980429  DT.318526  DT.100017910  DT.120892661  DT.95216676  DT.100648725  DT.100795600  DT.120892618 
    DT.120892688  DT.95072418  DT.120892621  DT.95171434 

    24/294 AceView cDNA sequences (see all 294):

    AF035311 CA433573 AI653618 BX386672 AK128280 BF724205 AI478482 BQ014669 
    CB130963 BM807980 AI056210 AA856880 BX503996 BU630184 CR620304 BX401067 
    BM918169 AA069471 BU623386 AI688152 AW292334 BG696868 AW594436 BX108372 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                -     -     -     -     -                                                                           
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                  -     -                                                                           


    ECgene alternative splicing isoforms for KPNA1

    Expression
    for KPNA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KPNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KPNA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    KidneyMetanephrosKidney
    LungTracheaLung
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KPNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KPNA1

    SOURCE GeneReport for Unigene cluster: Hs.161008

    UniProtKB/Swiss-Prot: IMA1_HUMAN, P52294
    Tissue specificity: Expressed ubiquitously

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    Orthologs
    for KPNA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA1 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KPNA11 karyopherin alpha 1 (importin alpha 5) 82.22(n)
    95.72(a)    		   418271  NM_001030774.1  NP_001025945.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KPNA16
    		 --
    		 96(a)
    		 1 ↔ 1
    		 GL343473.1(45931-92194)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX851302.12   -- 79.1(n)    BX851302.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5725421 importin subunit alpha-1-like 74.48(n)
    85.74(a)    		   572542  XM_696267.5  XP_701359.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Kap-alpha13 protein-nucleus import protein carrier 61(a)
    (best of 2)    		   76C6   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MOS61 Importin subunit alpha-2 57.98(n)
    55.96(a)    		   827472  NM_116447.2  NP_192124.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 importin subunit alpha, putative, expressed
    (see all 4)    		 54(a)
    53(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 5(3251056-3256018)
    1(8381094-8386260)


    ENSEMBL Gene Tree for KPNA1 (if available)
    TreeFam Gene Tree for KPNA1 (if available) 

    Paralogs
    for KPNA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KPNA1 gene
    KPNA32  KPNA72  SPAG62  KPNA52  KPNA22  KPNA42  KPNA62  
    6 SIMAP similar genes for KPNA1 using alignment to 8 protein entries:     IMA1_HUMAN (see all proteins):
    KPNA5    KPNA6    KPNA4    KPNA3    KPNA2    KPNA7

    KPNA1 for paralogs           About GeneDecksing



    Genomic Variants
    for KPNA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1456 NCBI SNPs in KPNA1 are shown (see all 1456)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs592800511,2
    		C,--122140426(+) CACCCA/GGCTAG 2 -- ds50010--------
    rs1915721741,2
    		--122140484(+) TGGTCC/TCGATC 2 -- ds50010--------
    rs558536771,2
    		C,--122140616(+) GCTATG/AACAAT 2 -- ds50014Minor allele frequency- A:0.23WA NA EA 360
    rs1158749251,2
    		--122140741(+) GAATTC/GCTTTG 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1848903661,2
    		--122140848(+) TCACCA/CATGGC 2 -- nc-transcript-variantut310--------
    rs557816081,2
    		C,--122140919(+) ACACTT/CTGAAG 2 -- nc-transcript-variantut314Minor allele frequency- C:0.10NA WA EA 360
    rs2006096291,2
    		--122141130(+) CACAT-/TTGTGCGT 2 -- nc-transcript-variantut310--------
    rs119321,2
    		C,F,O,H,--122141135(+) TTGTGC/TGTTTG 2 -- ut31 nc-transcript-variant24Minor allele frequency- T:0.20MN NS EA NA WA 2948
    rs1896385671,2
    		--122141392(+) AAAGGC/TTGGCC 2 -- ut31 nc-transcript-variant0--------
    rs1445125031,2
    		--122141398(+) TGGCCC/TAGCTG 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for KPNA1 (122140748 - 122233792 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KPNA1: --
    Human Gene Mutation Database (HGMD): KPNA1

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    Disorders / Diseases
    for KPNA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KPNA1 for disorders           About GeneDecksing

    OMIM gene information: 600686    OMIM disorders: --

    9 diseases for KPNA1:    About MalaCards
    retinitis pigmentosa    alzheimer's disease    retinitis    influenza
    ataxia    hypoxia    immunodeficiency    malaria
    neuronitis


    Export disorders for KPNA1 gene to outside databases

    Publications
    for KPNA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KPNA1 gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with KPNA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. (PubMed id 8052633)1, 2, 3 Cortes P.... Baltimore D. (1994)
    2. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. (PubMed id 19118899)1, 2, 9 Simkus C....Jones J.M. (2009)
    3. NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. (PubMed id 7831767)1, 2, 9 O'Neill R.E. and Palese P. (1995)
    4. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PubMed id 7604027)1, 2, 9 Moroianu J.... Radu A. (1995)
    5. CTNNBL1 is a novel nuclear localization sequence-bind ing protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K....Neuberger M. (2011)
    6. Ebola Virus VP24 Binds karyopherin alpha-1 and blocks STAT1 nuclear accumulation. (PubMed id 16698996)1, 2 Reid S.P.... Basler C.F. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (2003)
    9. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. (PubMed id 9463369)1, 2 Popov S.... Bukrinsky M. (1998)
    10. The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence. (PubMed id 8692858)1, 2 Moroianu J.... Radu A. (1996)

    External Searches for KPNA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing KPNA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3836 HGNC: 6394 AceView: KPNA1 Ensembl:ENSG00000114030 euGenes: HUgn3836
    ECgene: KPNA1 Kegg: 3836 H-InvDB: KPNA1

    Other Databases showing KPNA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KPNA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KPNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KPNA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KPNA1 gene:
    Search GeneIP for patents involving KPNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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