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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KPNA1 Gene

protein-coding   GIFtS: 65
GCID: GC03M122140

Karyopherin Alpha 1 (Importin Alpha 5)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Karyopherin Alpha 1 (Importin Alpha 5)1 2     SRP12 5
RCH22 3 5     IPOA52
Karyopherin Subunit Alpha-12 3     Importin Alpha 52
Nucleoprotein Interactor 12 3     Importin Subunit Alpha-12
NPI-12 3     Importin Subunit Alpha-52
SRP1-beta2 3     importin-alpha-S12
RAG Cohort Protein 22 3     Recombination Activating Gene Cohort 22

External Ids:    HGNC: 63941   Entrez Gene: 38362   Ensembl: ENSG000001140307   OMIM: 6006865   UniProtKB: P522943   
ORGUL members:         
NONCODE14:n407230 n339470      

Export aliases for KPNA1 gene to outside databases

Previous GC identifers: GC03M118866 GC03M122093 GC03M123425 GC03M123465 GC03M123627 GC03M119513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KPNA1 Gene:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear
pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear
pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded
by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein
interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1
ubiquitin ligase. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for KPNA1 Gene: 
KPNA1 (karyopherin alpha 1 (importin alpha 5)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with KPNA1 include retinitis pigmentosa, and influenza, and among its related super-pathways are Interferon Signaling and Influenza Life Cycle. GO annotations related to this gene include protein transporter activity and nuclear localization sequence binding. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
cytomegalovirus UL84 by recognizing a non-classical NLS

Gene Wiki entry for KPNA1 (Karyopherin alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KPNA1 gene promoter:
         Max1   USF1   Evi-1   Nkx6-1   POU2F1   USF-1   POU2F1b   POU2F1a   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKPNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KPNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KPNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

KPNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KPNA1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122140:  view genomic region     (about GC identifiers)

Start:
122,140,748 bp from pter      End:
122,233,792 bp from pter
Size:
93,045 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for KPNA1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294 (See protein sequence)
Recommended Name: Importin subunit alpha-5  
Size: 538 amino acids; 60222 Da
Subunit: Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF;
the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required
for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with the nucleoprotein of
influenza A viruses. Binds to HCMV (human cytomegalovirus) UL84, HIV-1 Vpr and to ebolavirus VP24. Interacts with
APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with
SNAI1 (via zinc fingers)
Subcellular location: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for KPNA1:
2JDQ (3D)        3TJ3 (3D)    
Secondary accessions: D3DN93 Q6IBQ9 Q9BQ56

Explore the universe of human proteins at neXtProt for KPNA1: NX_P52294

Explore proteomics data for KPNA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated in the presence of RAG1 (in vitro)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52294

  • KPNA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KPNA1 Protein Expression
    REFSEQ proteins: NP_002255.3  
    ENSEMBL proteins: 
     ENSP00000343701   ENSP00000420013   ENSP00000418394   ENSP00000419890   ENSP00000417166  
     ENSP00000417319   ENSP00000419257  
    Reactome Protein details: P52294
    Human Recombinant Protein Products for KPNA1: 
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    Novus Biologicals KPNA1 Proteins
    Novus Biologicals KPNA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005643nuclear pore TAS8052633
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS7754385
    GO:0005829cytosol TAS--

    KPNA1 for ontologies           About GeneDecksing



    KPNA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KPNA1
    R&D Systems Antibodies for KPNA1 (Importin alpha 5/KPNA1)
    OriGene Antibodies for KPNA1
    OriGene Custom Antibody Services for KPNA1
    GenScript Custom Superior Antibodies Services for KPNA1
    Novus Biologicals KPNA1 Antibodies
    Abcam antibodies for KPNA1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for KPNA1
    LSBio Antibodies in human, mouse, rat for KPNA1 

    Assay Products for KPNA1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KPNA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARMC: Armadillo repeat containing
    IPO: Importins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR024931 Importing_su_alpha
     IPR002652 Importin-a_IBB
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52294

    ProtoNet protein and cluster: P52294

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB002652 Importin alpha-like protein


    UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
    Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a
    short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB
    domain), which is sufficient for binding importin beta and essential for nuclear protein import
    Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the
    internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high
    affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in
    the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By
    similarity)
    Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS
    motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn
    residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By
    similarity)
    Similarity: Belongs to the importin alpha family
    Similarity: Contains 10 ARM repeats
    Similarity: Contains 1 IBB domain


    KPNA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMA5_HUMAN, P52294
    Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically
    and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate
    complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and
    the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha
    and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The
    directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and
    GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human
    cytomegalovirus UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12011095
    GO:0008139nuclear localization sequence binding TAS7754385
    GO:0008565protein transporter activity IEA--
         
    KPNA1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kpna1):
     behavior/neurological  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    KPNA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kpna1tm1.2Yyo for KPNA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KPNA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KPNA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KPNA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KPNA1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KPNA1
    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA1 (see all 215):
    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KPNA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KPNA1

    Gene Editing
    Products:
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KPNA1 (see all 6)
    OriGene ORF clones in mouse, rat for KPNA1
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    GenScript: all cDNA clones in your preferred vector: KPNA1 (NM_002264)
    Sino Biological Human cDNA Clone for KPNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KPNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KPNA1
    Sirion Biotech Customized lentivirus for stable overexpression of KPNA1 
                         Customized lentivirus expression plasmids for stable overexpression of KPNA1 

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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KPNA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KPNA1 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    2Viral mRNA Translation
    Influenza Life Cycle0.95
    Influenza Infection0.95
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Vpr-mediated nuclear import of PICs0.91
    Interactions of Vpr with host cellular proteins0.91
    4HIV Life Cycle
    HIV Infection0.61
    Host Interactions of HIV factors0.60
    5Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KPNA1
        Cell cycle Spindle assembly and chromosome separation

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KPNA1
        Ran Pathway
    JAK-STAT Pathway
    NFAT in Immune Response

    1 GeneGo (Thomson Reuters) Pathway for KPNA1
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for KPNA1
        Class I PI3K signaling events mediated by Akt


    5/17        Reactome Pathways for KPNA1 (see all 17)
        Activation of DNA fragmentation factor
    Antiviral mechanism by IFN-stimulated genes
    Transport of Ribonucleoproteins into the Host Nucleus
    Apoptosis
    Disease


    1         Kegg Pathway  (Kegg details for KPNA1):
        Influenza A


    KPNA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KPNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/670 Interacting proteins for KPNA1 (P522942, 3 ENSP000003437014) via UniProtKB, MINT, STRING, and/or I2D (see all 670)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK6Q165942, 3MINT-2860217 MINT-7945693 I2D: score=3 
    ANP32AP396872, 3, ENSP000004178644MINT-2860174 I2D: score=3 STRING: ENSP00000417864
    LMO4P619682, 3, ENSP000003595734MINT-60896 I2D: score=3 STRING: ENSP00000359573
    RELBQ012012, 3, ENSP000002214524MINT-48976 I2D: score=2 STRING: ENSP00000221452
    STAT3P407632, 3, ENSP000002646574MINT-6803345 I2D: score=2 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000018regulation of DNA recombination TAS8052633
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006606protein import into nucleus ----
    GO:0006607NLS-bearing substrate import into nucleus TAS7754385
    GO:0006915apoptotic process TAS--

    KPNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KPNA1 (IMA5)

    1 HMDB Compound for KPNA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about KPNA1 / IMA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KPNA1 gene: 
    NM_002264.3  

    Unigene Cluster for KPNA1:

    Karyopherin alpha 1 (importin alpha 5)
    Hs.161008  [show with all ESTs]
    Unigene Representative Sequence: NR_026698
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344337(uc003efb.1 uc003efc.1 uc011bjr.1 uc010hrh.2 uc003efe.2)
    ENST00000470904 ENST00000466923 ENST00000485027 ENST00000494339 ENST00000465882
    ENST00000464940 ENST00000482287 ENST00000476916 ENST00000493510
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate KPNA1 (see all 215):
    hsa-miR-576-3p hsa-miR-520f hsa-miR-3938 hsa-miR-519a hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-298
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KPNA1

    Additional mRNA sequence: 

    AF035311.1 AK125626.1 AK128280.1 AK299030.1 BC002374.2 BC003009.1 BC029937.1 BC090864.1 
    BT006959.1 CR456743.1 NR_026698.1 U20620.1 

    20 DOTS entries:

    DT.102830070  DT.70103798  DT.456193  DT.95171435  DT.100795589  DT.92470132  DT.95324085  DT.100795596 
    DT.101980429  DT.318526  DT.100017910  DT.120892661  DT.95216676  DT.100648725  DT.100795600  DT.120892618 
    DT.120892688  DT.95072418  DT.120892621  DT.95171434 

    24/294 AceView cDNA sequences (see all 294):

    BU738827 AA888100 BU189316 AA069471 BG287593 BX401067 BG696868 AK128280 
    BX386672 AI688152 F13310 BQ576083 AW594436 CA433573 CB130963 BM918169 
    BQ014669 AI189712 AW292334 CB158790 CR620304 BU623386 AI721045 BX108372 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KPNA1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                -     -     -     -     -                                                                           
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                  -     -                                                                           


    ECgene alternative splicing isoforms for KPNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KPNA1 expression in normal human tissues (normalized intensities)      KPNA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KPNA1 Expression
    About this image


    KPNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             urinary bladder ; urothelial cells   
             visceral organ/urethra of male   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             posterior singulate   

    See KPNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KPNA1

    SOURCE GeneReport for Unigene cluster: Hs.161008

    UniProtKB/Swiss-Prot: IMA5_HUMAN, P52294
    Tissue specificity: Expressed ubiquitously

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KPNA1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kpna11 , 5 karyopherin (importin) alpha 11, 5 92.87(n)1
    97.77(a)1
      16 (25.43 cM)5
    166461  NM_008465.51  NP_032491.21 
     359787505 
    chicken
    (Gallus gallus)
    Aves KPNA11 karyopherin alpha 1 (importin alpha 5) 82.22(n)
    95.72(a)
      418271  NM_001030774.1  NP_001025945.1 
    lizard
    (Anolis carolinensis)
    Reptilia KPNA16
    Importin subunit alpha
    79(a)
    1 ↔ 1
    GL343473.1(32012-92226)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851302.12   -- 79.1(n)    BX851302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5725421 importin subunit alpha-1-like 74.48(n)
    85.74(a)
      572542  XM_696267.5  XP_701359.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kap-alpha13 protein-nucleus import protein carrier 61(a)
    (best of 2)
      76C6   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP16
    Karyopherin alpha homolog, forms a dimer with kary...
    50(a)
    1 → many
    XIV(284260-285888)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MOS61 Importin subunit alpha-2 57.98(n)
    55.96(a)
      827472  NM_116447.2  NP_192124.1 
    barley
    (Hordeum vulgare)
    Liliopsida BI948483.12   -- 76.97(n)    BI948483.1 


    ENSEMBL Gene Tree for KPNA1 (if available)
    TreeFam Gene Tree for KPNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KPNA1 gene
    KPNA72  KPNA32  SPAG62  KPNA52  KPNA22  KPNA42  KPNA62  
    6 SIMAP similar genes for KPNA1 using alignment to 8 protein entries:     IMA5_HUMAN (see all proteins):
    KPNA5    KPNA6    KPNA2    KPNA4    KPNA3    KPNA7

    KPNA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1811 SNPs in KPNA1 are shown (see all 1811)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114548321,2
    C--122140260(+) TCAGC-/T/TT  
            
    TTTTT
    2 -- ds50010--------
    rs592800511,2
    C--122140426(+) CACCCA/GGCTAG 2 -- ds50010--------
    rs1915721741,2
    --122140484(+) TGGTCC/TCGATC 2 -- ds50010--------
    rs558536771,2
    C--122140616(+) GCTATG/AACAAT 2 -- ds50014Minor allele frequency- A:0.23WA NA EA 360
    rs1158749251,2
    F--122140741(+) GAATTC/GCTTTG 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1848903661,2
    --122140848(+) TCACCA/CATGGC 2 -- ut31 nc-transcript-variant0--------
    rs557816081,2
    C--122140919(+) ACACTT/CTGAAG 2 -- ut31 nc-transcript-variant4Minor allele frequency- C:0.10NA WA EA 360
    rs2006096291,2
    C--122141130(+) CCACA-/TTGTGTGC 2 -- cds1 nc-transcript-variant0--------
    rs119321,2
    C,F,O,H--122141135(+) TTGTGC/TGTTTG 2 -- ut31 nc-transcript-variant24Minor allele frequency- T:0.20MN NS EA NA WA 2948
    rs352066351,2
    C--122141192(+) TGCAC-/A/AA  
            
    AAAAA
    4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for KPNA1 (122140748 - 122233792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KPNA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3974CNV Insertion18451855
    nsv877391CNV Gain21882294


    Human Gene Mutation Database (HGMD): KPNA1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600686    OMIM disorders: --

    7 diseases for KPNA1:    About MalaCards
    retinitis pigmentosa    influenza    retinitis    hypoxia
    alzheimer's disease    endotheliitis    neuronitis


    KPNA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for KPNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KPNA1 gene, integrated from 9 sources (see all 181):
    (articles sorted by number of sources associating them with KPNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. (PubMed id 8052633)1, 2, 3 Cortes P.... Baltimore D. (1994)
    2. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. (PubMed id 19118899)1, 2, 9 Simkus C....Jones J.M. (2009)
    3. NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. (PubMed id 7831767)1, 2, 9 O'Neill R.E. and Palese P. (1995)
    4. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PubMed id 7604027)1, 2, 9 Moroianu J.... Radu A. (1995)
    5. Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). (PubMed id 15942031)1, 2, 9 Jackson E.B....Izumi T. (2005)
    6. CTNNBL1 is a novel nuclear localization sequence-bind ing protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K....Neuberger M. (2011)
    7. Ebola Virus VP24 Binds karyopherin alpha-1 and blocks STAT1 nuclear accumulation. (PubMed id 16698996)1, 2 Reid S.P.... Basler C.F. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (2003)
    10. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. (PubMed id 9463369)1, 2 Popov S.... Bukrinsky M. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3836 HGNC: 6394 AceView: KPNA1 Ensembl:ENSG00000114030 euGenes: HUgn3836
    ECgene: KPNA1 Kegg: 3836 H-InvDB: KPNA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KPNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KPNA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KPNA1 gene:
    Search GeneIP for patents involving KPNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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