Aliases for KNTC1 Gene
External Ids for KNTC1 Gene
Previous GeneCards Identifiers for KNTC1 Gene
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for KNTC1 Gene
KNTC1 (Kinetochore Associated 1) is a Protein Coding gene. Diseases associated with KNTC1 include Histrionic Personality Disorder and Orbital Plasma Cell Granuloma. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases.
UniProtKB/Swiss-Prot for KNTC1 Gene
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.