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KNTC1 Gene

protein-coding   GIFtS: 57
GCID: GC12P123011

Kinetochore Associated 1
  See related diseases
at
MalaCards
 

Aliases
for KNTC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinetochore Associated 11 2     Rough Deal Homolog, Centromere/Kinetochore Protein2
ROD2 5     HsROD3
KIAA01663 5     Rod3
Rough Deal Homolog (Drosophila)1     hRod3
Kinetochore-Associated Protein 12     Rough Deal Homolog3

External Ids:    HGNC: 172551   Entrez Gene: 97352   Ensembl: ENSG000001844457   OMIM: 6073635   UniProtKB: P507483   

Export aliases for KNTC1 gene to outside databases

Previous GC identifers: GC12M121730 GC12U900005 GC12P122820 GC12P121450 GC12P121451 GC12P121536 GC12P121577 GC12P119972


Summaries
for KNTC1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KNTC1 Gene:
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation
during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to
that of the Drosophila rough deal protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for KNTC1 Gene:
KNTC1 (kinetochore associated 1) is a protein-coding gene. Diseases associated with KNTC1 include orbital plasma cell granuloma, and histrionic personality disorder.

UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores




Genomic Views
for KNTC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KNTC1 gene promoter:
         Max1   Elk-1   Lmo2   E4BP4   HEN1   PPAR-gamma2   Pax-4a   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KNTC1 promoter sequence
   Search Chromatin IP Primers for KNTC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KNTC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

KNTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KNTC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P123011:  view genomic region     (about GC identifiers)

Start:
 123,011,793 bp from pter      End:
 123,110,947 bp from pter
Size:
 99,155 bases      Orientation:
 plus strand

Proteins
for KNTC1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748 (See protein sequence)
Recommended Name: Kinetochore-associated protein 1  
Size: 2209 amino acids; 250749 Da
Subunit: Interacts with ZW10. This interaction is required for stable association with the kinetochore. Component
of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH
Sequence caution: Sequence=BAA11483.2; Type=Erroneous initiation;
Secondary accessions: A7E2C4

Explore the universe of human proteins at neXtProt for KNTC1: NX_P50748

Explore proteomics data for KNTC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys625
  • Modification sites at PhosphoSitePlus

    • See KNTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055523.1  
    ENSEMBL proteins: 
     ENSP00000397992   ENSP00000328236   ENSP00000397140   ENSP00000408760   ENSP00000439119  
     ENSP00000437344   ENSP00000443622  
    Reactome Protein details: P50748

    KNTC1 Human Recombinant Protein Products:

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    KNTC1 Assay Products:

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    Domains /
    Families
    for KNTC1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 2 InterPro protein domains:
     IPR017986 WD40_repeat_dom
     IPR019527 RZZ-complex_KNTC1/ROD_C

    Graphical View of Domain Structure for InterPro Entry P50748

    ProtoNet protein and cluster: P50748


    KNTC1 for domains           About GeneDecksing


    Function
    for KNTC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KNTC1_HUMAN, P50748
    Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
    Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11146660
         
    KNTC1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KNTC1:
     Decreased number of cells in m  Increased cell death in breast  Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KNTC1
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    miRNA
    Products:            		miRTarBase miRNAs that target KNTC1:
    hsa-mir-149-5p (MIRT045471), hsa-mir-183-5p (MIRT047167), hsa-mir-193b-3p (MIRT016317), hsa-mir-484 (MIRT041835)

    Block miRNA regulation of human, mouse, rat KNTC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KNTC1
    SwitchGear 3'UTR luciferase reporter plasmid: KNTC1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Localization
    for KNTC1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KNTC1_HUMAN, P50748: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
    Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the
    cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is
    concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently
    at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle
    fibers, but still present at the spindle poles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IDA11146660
    GO:0005634nucleus NAS11146660
    GO:0005737cytoplasm IDA--
    GO:0005828kinetochore microtubule IDA11146660

    KNTC1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for KNTC1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KNTC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    		Mitotic Anaphase0.94
    		Mitotic Metaphase and Anaphase0.93
    		Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    		Cell Cycle, Mitotic0.90
    		M Phase0.62
    		Cell Cycle0.90
    3Mitotic Prometaphase
    		Mitotic Prometaphase0.92
    		Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for KNTC1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    KNTC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KNTC1: 
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KNTC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for KNTC1 (P507483 ENSP000003971404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403373I2D: score=2 
    ZW10O432643I2D: score=2 
    ZWILCHQ9H9003I2D: score=1 
    --ensp: ENSP000003282364STRING: ensp: ENSP00000328236
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006461protein complex assembly NAS11146660
    GO:0007067mitosis IEA--
    GO:0007093mitotic cell cycle checkpoint IDA11146660

    KNTC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KNTC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KNTC1



    Transcripts
    for KNTC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KNTC1 gene: 
    NM_014708.4  

    Unigene Cluster for KNTC1:

    Kinetochore associated 1
    Hs.300559  [show with all ESTs]
    Unigene Representative Sequence: BC150278
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535410 ENST00000450485 ENST00000333479(uc001ucv.3 uc010taf.2)
    ENST00000535186 ENST00000423927 ENST00000545065 ENST00000377192 ENST00000436959
    ENST00000541466 ENST00000546125 ENST00000536625 ENST00000542727 ENST00000539013
    ENST00000541427 ENST00000534995 ENST00000537348
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: KNTC1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: KNTC1 (NM_014708)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KNTC1
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      QuantiFast Probe-based Assays in human, mouse, rat KNTC1

    Additional mRNA sequence: 

    AK093470.1 AK293403.1 AK303337.1 BC150278.1 D79988.1 

    15 DOTS entries:

    DT.114572  DT.100783292  DT.114574  DT.92426914  DT.91754770  DT.95289644  DT.100716343  DT.102826270 
    DT.86848374  DT.91648596  DT.92426907  DT.92426909  DT.92426911  DT.86851106  DT.97804374 

    Selected AceView cDNA sequences (see all 131):

    BF513370 AK093470 D79988 BC055410 BM772271 AW235746 AA157787 AU142399 
    AV686551 NM_014708 AA282078 AI380277 BQ366585 AA417766 AW450633 AA563881 
    AW629521 BX364485 BM794708 BQ267926 AA582454 BM697763 BQ946378 AU131338 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KNTC1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^
    SP1:                                                                                                                          -           -                     
    SP2:                                                              -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                              -                                                                                             

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:        -                                                   
    SP5:                                                            


    ECgene alternative splicing isoforms for KNTC1

    Expression
    for KNTC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KNTC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAATAA
    KNTC1 Expression
    About this image

    KNTC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    KNTC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300559

    UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748
    Tissue specificity: High expression in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including KNTC1: 
              Cell Cycle in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KNTC1

    Orthologs
    for KNTC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for KNTC1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kntc11 , 5 kinetochore associated 11, 5 81.36(n)1
    81.21(a)1    		   5 (63.17 cM)5
    2086281  NM_001042421.11  NP_001035886.11 
     1237497265 
    chicken
    (Gallus gallus)    		 Aves KNTC11 kinetochore associated 1 67.48(n)
    61.44(a)    		   416865  XM_415157.4  XP_415157.4 
    lizard
    (Anolis carolinensis)    		 Reptilia KNTC16
    		 kinetochore associated 1
    		 51(a)
    		 1 ↔ 1
    		 GL343423.1(226934-306190)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.96222 Xenopus laevis transcribed sequence with weak similarity more 74.38(n)    BX845940.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kntc11 kinetochore associated 1 54.66(n)
    48.31(a)    		   497376  XM_681266.6  XP_686358.6 
    fruit fly
    (Drosophila melanogaster)    		 Insecta rod6
    		 rough deal
    		 17(a)
    		 1 ↔ 1
    		 3R(27406394-27413861)
    worm
    (Caenorhabditis elegans)    		 Secernentea rod-16
    		 Protein ROD-1 (rod-1) mRNA, complete cds
    		 16(a)
    		 1 ↔ 1
    		 IV(7478452-7485519) WBGene00018900


    ENSEMBL Gene Tree for KNTC1 (if available)
    TreeFam Gene Tree for KNTC1 (if available)

    Paralogs
    for KNTC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KNTC1 gene

    KNTC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KNTC1
    PGOHUM00000239596


    Genomic Variants
    for KNTC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for KNTC1 (see all 2108)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs128163961,2
    		C,F--122825103(+) TCGAAA/TCATAG 1 -- us2k16Minor allele frequency- T:0.17NA CSA WA EA 363
    rs1872928611,2
    		--122825171(+) TCTAGA/GGGACT 1 -- us2k10--------
    rs1932010951,2
    		--122825177(+) GGACTA/GTCTTT 1 -- us2k10--------
    rs1129519501,2
    		C,F--122825317(+) GGTCAG/AGAGTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs749769001,2
    		C,F--123013673(+) GGTGTG/TAGCCA 1 -- int12Minor allele frequency- T:0.06NA 124
    rs354165561,2
    		C,F--123013680(+) GCCACC/TGCGCC 1 -- int12Minor allele frequency- T:0.06NA 124
    rs1840103321,2
    		--123013682(+) CACCGC/TGCCGG 1 -- int10--------
    rs1509997241,2
    		--123013751(+) GATCAC/TCCAAG 1 -- int10--------
    rs1882840961,2
    		--123013765(+) AGCTGC/TCTAGT 1 -- int10--------
    rs751525641,2
    		F--123013859(+) CTTATG/AAAACC 1 -- int11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for KNTC1 (123011793 - 123110947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KNTC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658251CNV Deletion23128226
    esv2661880CNV Deletion23128226
    nsv826530CNV Loss20364138
    nsv826529CNV Gain20364138
    nsv899570CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KNTC1
    DNA2.0 Custom Variant and Variant Library Synthesis for KNTC1

    Disorders / Diseases
    for KNTC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607363    OMIM disorders: --

    10 diseases for KNTC1:    
    About MalaCards
    orbital plasma cell granuloma    histrionic personality disorder    dependent personality disorder    osteitis fibrosa
    personality disorder    hyperphosphatemia    renal osteodystrophy    osteomalacia
    narcolepsy    hyperparathyroidism

    7 diseases from the University of Copenhagen DISEASES database for KNTC1:
    Renal osteodystrophy     Osteomalacia     Hyperparathyroidism     Osteitis fibrosa
    Kidney failure     Histrionic personality disorder     Dependent personality disorder

    KNTC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KNTC1
    Human Genome Epidemiology (HuGE) Navigator: KNTC1 (3 documents)

    Export disorders for KNTC1 gene to outside databases

    Publications
    for KNTC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KNTC1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with KNTC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. (PubMed id 11590237)1, 2, 3 Scaeerou F....Goldberg M.L. (J. Cell Sci. 2001)
    2. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. (PubMed id 11146660)1, 2, 3 Chan G.K.T.... Yen T.J. (Nat. Cell Biol. 2000)
    3. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PubMed id 12686595)1, 2, 9 Williams B.C....Goldberg M.L. (Mol. Biol. Cell 2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)1, 2 Kops G.J.P.L.... Cleveland D.W. (J. Cell Biol. 2005)
    7. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)4 Dastani Z....Kathiresan S. (PLoS Genet. 2012)

    External Searches for KNTC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing KNTC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9735 HGNC: 17255 AceView: KNTC1 Ensembl:ENSG00000184445 euGenes: HUgn9735
    ECgene: KNTC1 H-InvDB: KNTC1

    Other Databases showing KNTC1 gene

    (According to HUGE)
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    HUGE: KIAA0166

    Specialized Databases showing KNTC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KNTC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KNTC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for KNTC1 gene:
    Search GeneIP for patents involving KNTC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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