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KNTC1 Gene

protein-coding GIFtS: 57
GCID: GC12P123011

Kinetochore Associated 1

See KNTC1-related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Kinetochore Associated 1¹ ²		Rough Deal Homolog, Centromere/Kinetochore Protein²
ROD² ⁵		HsROD³
KIAA0166³ ⁵		Rod³
Rough Deal Homolog (Drosophila)¹		hRod³
Kinetochore-Associated Protein 1²		Rough Deal Homolog³

External Ids:	HGNC: 17255¹	Entrez Gene: 9735²	Ensembl: ENSG00000184445⁷	OMIM: 607363⁵	UniProtKB: P50748³

Export aliases for KNTC1 gene to outside databases

Previous GC identifers: GC12M121730 GC12U900005 GC12P122820 GC12P121450 GC12P121451 GC12P121536 GC12P121577 GC12P119972

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KNTC1 Gene:

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation

during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to

that of the Drosophila rough deal protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for KNTC1 Gene:

KNTC1 (kinetochore associated 1) is a protein-coding gene. Diseases associated with KNTC1 include histrionic personality disorder, and dependent personality disorder.

UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748

Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.

Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NT_029419.13 NC_018923.2

Regulatory elements:

Regulatory transcription factor binding sites in the KNTC1 gene promoter:
Max1 Elk-1 Lmo2 E4BP4 HEN1 PPAR-gamma2 Pax-4a NF-kappaB1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KNTC1 promoter sequence

Search Chromatin IP Primers for KNTC1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KNTC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

KNTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KNTC1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P123011: view genomic region (about GC identifiers)

Start:	123,011,793 bp from pter	End:	123,110,947 bp from pter
Size:	99,155 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748 (See protein sequence)

Recommended Name: Kinetochore-associated protein 1

Size: 2209 amino acids; 250749 Da

Subunit: Interacts with ZW10. This interaction is required for stable association with the kinetochore. Component

of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH

Sequence caution: Sequence=BAA11483.2; Type=Erroneous initiation;

Secondary accessions: A7E2C4

Explore the universe of human proteins at neXtProt for KNTC1: NX_P50748

Explore proteomics data for KNTC1 at MOPED

Post-translational modifications:

Ubiquitination² at Lys625

Modification sites at PhosphoSitePlus

See KNTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055523.1

ENSEMBL proteins:

ENSP00000397992 ENSP00000328236 ENSP00000397140 ENSP00000408760 ENSP00000439119

ENSP00000437344 ENSP00000443622

Reactome Protein details: P50748

KNTC1 Human Recombinant Protein Products:

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	antibodies-online peptides for KNTC1

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KNTC1 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR017986 WD40_repeat_dom

IPR019527 RZZ-complex_KNTC1/ROD_C

Graphical View of Domain Structure for InterPro Entry P50748

ProtoNet protein and cluster: P50748

Find genes that share domains with KNTC1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: KNTC1_HUMAN, P50748

Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.

Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11146660

Find genes that share ontologies with KNTC1 About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for KNTC1:

Decreased number of cells in m

Increased cell death in breast

Lamellipodia cells

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for KNTC1

miRNA Products:		miRTarBase miRNAs that target KNTC1: hsa-mir-149-5p (MIRT045471), hsa-mir-183-5p (MIRT047167), hsa-mir-193b-3p (MIRT016317), hsa-mir-484 (MIRT041835)

		Block miRNA regulation of human, mouse, rat KNTC1 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat KNTC1

Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KNTC1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

KNTC1_HUMAN, P50748: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.

Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the

cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is

concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently

at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle

fibers, but still present at the spindle poles

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
nucleus	5
cytosol	4
extracellular	1
plasma membrane	1

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Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0000922	spindle pole	IDA	11146660
GO:0005634	nucleus	NAS	11146660
GO:0005737	cytoplasm	IDA	--
GO:0005828	kinetochore microtubule	IDA	11146660

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KNTC1 About

See pathways by source

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SuperPath

Contained pathways About

Mitotic Metaphase and Anaphase

	Separation of Sister Chromatids	0.94			Mitotic Metaphase and Anaphase	0.93
	Mitotic Anaphase	0.94

Cell Cycle, Mitotic

	Cell Cycle, Mitotic	0.90			M Phase	0.62
	Cell Cycle	0.90

Mitotic Prometaphase

Mitotic Prometaphase

0.92

Resolution of Sister Chromatid Cohesion

0.92

Find genes that share SuperPaths with KNTC1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

3 Reactome Pathways for KNTC1

	Resolution of Sister Chromatid Cohesion
	Mitotic Prometaphase
	Separation of Sister Chromatids

Pathway & Disease-focused RT² Profiler PCR Array including KNTC1:

Cell Cycle in human mouse rat

Interactions:

GeneGlobe Interaction Network for KNTC1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

4 Interacting proteins for KNTC1 (P50748³ ENSP00000397140⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VHL	P40337³	I2D: score=2
ZW10	O43264³	I2D: score=2
ZWILCH	Q9H900³	I2D: score=1
--	ensp: ENSP00000328236⁴	STRING: ensp: ENSP00000328236

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000278	mitotic cell cycle	TAS	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006461	protein complex assembly	NAS	11146660
GO:0007067	mitosis	IEA	--
GO:0007093	mitotic cell cycle checkpoint	IDA	11146660

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KNTC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KNTC1 gene:

NM_014708.4

Unigene Cluster for KNTC1:

Kinetochore associated 1

Hs.300559 [show with all ESTs]

Unigene Representative Sequence: BC150278

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000535410 ENST00000450485 ENST00000333479(uc001ucv.3 uc010taf.2)

ENST00000535186 ENST00000423927 ENST00000545065 ENST00000377192 ENST00000436959

ENST00000541466 ENST00000546125 ENST00000536625 ENST00000542727 ENST00000539013

ENST00000541427 ENST00000534995 ENST00000537348

miRNA Products:		Block miRNA regulation of human, mouse, rat KNTC1 using miScript Target Protectors
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		GenScript: all cDNA clones in your preferred vector: KNTC1 (NM_014708)
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		QuantiFast Probe-based Assays in human, mouse, rat KNTC1

Additional mRNA sequence:

AK093470.1 AK293403.1 AK303337.1 BC150278.1 D79988.1

15 DOTS entries:

DT.114572 DT.100783292 DT.114574 DT.92426914 DT.91754770 DT.95289644 DT.100716343 DT.102826270

DT.86848374 DT.91648596 DT.92426907 DT.92426909 DT.92426911 DT.86851106 DT.97804374

Selected AceView cDNA sequences (see all 131):

BF513370 AK093470 D79988 BC055410 BM772271 AW235746 AA157787 AU142399

AV686551 NM_014708 AA282078 AI380277 BQ366585 AA417766 AW450633 AA563881

AW629521 BX364485 BM794708 BQ267926 AA582454 BM697763 BQ946378 AU131338

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KNTC1 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	·	19c	^	20	^
SP1:																																									-				-
SP2:																					-
SP3:
SP4:
SP5:																					-

ExUns:	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29
SP1:
SP2:
SP3:
SP4:			-
SP5:

ECgene alternative splicing isoforms for KNTC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KNTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAATAAATAA

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KNTC1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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KNTC1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.300559

UniProtKB/Swiss-Prot: KNTC1_HUMAN, P50748

Tissue specificity: High expression in testis

Pathway & Disease-focused RT² Profiler PCR Array including KNTC1:

Cell Cycle in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KNTC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KNTC1 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kntc1^{1 , 5}	kinetochore associated 1^{1, 5}	81.36(n)¹ 81.21(a)¹		5 (63.17 cM)⁵ 208628¹ NM_001042421.1¹ NP_001035886.1¹ 123749726⁵
chicken (Gallus gallus)	Aves	KNTC1¹	kinetochore associated 1	67.48(n) 61.44(a)		416865 XM_415157.4 XP_415157.4
lizard (Anolis carolinensis)	Reptilia	KNTC1⁶	kinetochore associated 1	51(a)	1 ↔ 1	GL343423.1(226934-306190)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9622²	Xenopus laevis transcribed sequence with weak similarity more	74.38(n)		BX845940.1
zebrafish (Danio rerio)	Actinopterygii	kntc1¹	kinetochore associated 1	54.66(n) 48.31(a)		497376 XM_681266.6 XP_686358.6
fruit fly (Drosophila melanogaster)	Insecta	rod⁶	rough deal	17(a)	1 ↔ 1	3R(27406394-27413861)
worm (Caenorhabditis elegans)	Secernentea	rod-1⁶	Protein ROD-1 (rod-1) mRNA, complete cds	16(a)	1 ↔ 1	IV(7478452-7485519) WBGene00018900

ENSEMBL Gene Tree for KNTC1 (if available)
TreeFam Gene Tree for KNTC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KNTC1 gene

Find genes that share paralogs with KNTC1 About GenesLikeMe

1 Pseudogenes.org Pseudogene for KNTC1
PGOHUM00000239596

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12816396^1,2	C,F	--	122825103(+)	`TCGAAA/TCATAG`	1	--	us2k¹		6		NA CSA WA EA	363
rs187292861^1,2		--	122825171(+)	`TCTAGA/GGGACT`	1	--	us2k¹		0	--	--	--	--
rs193201095^1,2		--	122825177(+)	`GGACTA/GTCTTT`	1	--	us2k¹		0	--	--	--	--
rs112951950^1,2	C,F	--	122825317(+)	`GGTCAG/AGAGTT`	1	--	us2k¹		1		CSA	2
rs74976900^1,2	C,F	--	123013673(+)	`GGTGTG/TAGCCA`	1	--	int¹		2		NA	124
rs35416556^1,2	C,F	--	123013680(+)	`GCCACC/TGCGCC`	1	--	int¹		2		NA	124
rs184010332^1,2		--	123013682(+)	`CACCGC/TGCCGG`	1	--	int¹		0	--	--	--	--
rs150999724^1,2		--	123013751(+)	`GATCAC/TCCAAG`	1	--	int¹		0	--	--	--	--
rs188284096^1,2		--	123013765(+)	`AGCTGC/TCTAGT`	1	--	int¹		0	--	--	--	--
rs75152564^1,2	F	--	123013859(+)	`CTTATG/AAAACC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for KNTC1 (123011793 - 123110947 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for KNTC1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2658251	CNV	Deletion	23128226
esv2661880	CNV	Deletion	23128226
nsv826530	CNV	Loss	20364138
nsv826529	CNV	Gain	20364138
nsv899570	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KNTC1

DNA2.0 Custom Variant and Variant Library Synthesis for KNTC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607363 OMIM disorders: --

3 diseases for KNTC1:
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histrionic personality disorder dependent personality disorder osteitis fibrosa

7 inferred disease relationships from the University of Copenhagen DISEASES database for KNTC1:

Renal osteodystrophy Osteomalacia Hyperparathyroidism Osteitis fibrosa

Kidney failure Histrionic personality disorder Dependent personality disorder

Find genes that share disorders with KNTC1 About GenesLikeMe

Genetic Association Database (GAD): KNTC1
Human Genome Epidemiology (HuGE) Navigator: KNTC1 (3 documents)

Export disorders for KNTC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KNTC1 gene, integrated from 10 sources (see all 31):
(articles sorted by number of sources associating them with KNTC1)

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The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. (PubMed id 11590237)^{1, 2, 3} Scaeerou F....Goldberg M.L. (J. Cell Sci. 2001)
Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. (PubMed id 11146660)^{1, 2, 3} Chan G.K.T.... Yen T.J. (Nat. Cell Biol. 2000)
Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PubMed id 12686595)^{1, 2, 9} Williams B.C....Goldberg M.L. (Mol. Biol. Cell 2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)^{1, 4} Shimada M....Tokunaga K. (Hum. Genet. 2010)
ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)^{1, 2} Kops G.J.P.L.... Cleveland D.W. (J. Cell Biol. 2005)
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)^{1, 2} Nagase T.... Nomura N. (DNA Res. 1996)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)⁴ Dastani Z....Kathiresan S. (PLoS Genet. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9735	HGNC: 17255	AceView: KNTC1	Ensembl:ENSG00000184445	euGenes: HUgn9735
ECgene: KNTC1	H-InvDB: KNTC1

(According to HUGE)
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HUGE: KIAA0166

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KNTC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KNTC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KNTC1 gene:
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KNTC1 Gene

Kinetochore Associated 1

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KNTC1 Gene

Kinetochore Associated 1

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