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Aliases for KNSTRN Gene

Aliases for KNSTRN Gene

  • Kinetochore-Localized Astrin/SPAG5 Binding Protein 2 3
  • Kinetochore-Localized Astrin-Binding Protein 2 3 4
  • C15orf23 3 4 6
  • SKAP 3 4 6
  • Kinetochore-Localized Astrin/SPAG5-Binding Protein 3 4
  • Small Kinetochore-Associated Protein 2 3
  • TRAF4 Associated Factor 1 2 3
  • TRAF4-Associated Factor 1 3 4
  • Kinastrin 3 4
  • TRAF4AF1 3 4
  • Small Kinetochore-Associated Protein, Kinetochore-Localized Astrin-Binding Protein, TRAF4 Associated Factor 1 3
  • Small Kinetochore Associated Protein 3
  • Chromosome 15 Open Reading Frame 23 2
  • Putative TRAF4-Associated Factor 1 3
  • HSD11 3

External Ids for KNSTRN Gene

Previous Symbols for KNSTRN Gene

  • C15orf23

Summaries for KNSTRN Gene

GeneCards Summary for KNSTRN Gene

KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KNSTRN Gene

  • Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNSTRN Gene

Genomics for KNSTRN Gene

Genomic Location for KNSTRN Gene

Start:
40,382,721 bp from pter
End:
40,394,288 bp from pter
Size:
11,568 bases
Orientation:
Plus strand

Genomic View for KNSTRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KNSTRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNSTRN Gene

No data available for Regulatory Elements for KNSTRN Gene

Proteins for KNSTRN Gene

  • Protein details for KNSTRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y448-SKAP_HUMAN
    Recommended name:
    Small kinetochore-associated protein
    Protein Accession:
    Q9Y448
    Secondary Accessions:
    • B4DXA7
    • Q147U5
    • Q32Q57
    • Q5ISJ0
    • Q6P2S5
    • Q6PJM0
    • Q86XB4

    Protein attributes for KNSTRN Gene

    Size:
    316 amino acids
    Molecular mass:
    35438 Da
    Quaternary structure:
    • Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with SPAG5. Directly binds to microtubules, although at relatively low affinity. Interacts with CENPE; this interaction greatly favors microtubule-binding. Interacts with DSN1/MIS13; leading to localization to kinetochores. Interacts with MAPRE1/EB1; leading to localization to the microtubule plus ends. Interacts with PRPF19.
    SequenceCaution:
    • Sequence=AAH04543.1; Type=Erroneous termination; Positions=174; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH14060.1; Type=Erroneous termination; Positions=174; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAI07803.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KNSTRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KNSTRN Gene

Proteomics data for KNSTRN Gene at MOPED

Post-translational modifications for KNSTRN Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys212

No data available for DME Specific Peptides for KNSTRN Gene

Domains for KNSTRN Gene

Protein Domains for KNSTRN Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y448

UniProtKB/Swiss-Prot:

SKAP_HUMAN
Domain:
  • The coiled coil regions mediate binding to kinetochores.:
    • Q9Y448
genes like me logo Genes that share domains with KNSTRN: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KNSTRN Gene

Function for KNSTRN Gene

Molecular function for KNSTRN Gene

UniProtKB/Swiss-Prot Function: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).
UniProtKB/Swiss-Prot Induction: Degraded at the end of mitosis. Down-regulated upon exposure to nitric oxide.

Gene Ontology (GO) - Molecular Function for KNSTRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21402792
genes like me logo Genes that share ontologies with KNSTRN: view

Phenotypes for KNSTRN Gene

genes like me logo Genes that share phenotypes with KNSTRN: view

miRNA for KNSTRN Gene

miRTarBase miRNAs that target KNSTRN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KNSTRN Gene

Localization for KNSTRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNSTRN Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). {ECO:0000269 PubMed:19667759, ECO:0000269 PubMed:21402792, ECO:0000269 PubMed:22110139, ECO:0000269 PubMed:23035123}.

Gene Ontology (GO) - Cellular Components for KNSTRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 21402792
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KNSTRN: view

No data available for Subcellular locations from COMPARTMENTS for KNSTRN Gene

Pathways for KNSTRN Gene

SuperPathways for KNSTRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for KNSTRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 21402792
GO:0007051 spindle organization IMP 21402792
GO:0007059 chromosome segregation IMP 21402792
GO:0051301 cell division IEA --
GO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP 21402792
genes like me logo Genes that share ontologies with KNSTRN: view

No data available for Pathways by source for KNSTRN Gene

Transcripts for KNSTRN Gene

Unigene Clusters for KNSTRN Gene

Kinetochore-localized astrin/SPAG5 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KNSTRN Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: -
SP10:
SP11:

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KNSTRN Gene

GeneLoc Exon Structure for
KNSTRN
ECgene alternative splicing isoforms for
KNSTRN

Expression for KNSTRN Gene

mRNA expression in normal human tissues for KNSTRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KNSTRN Gene

This gene is overexpressed in Thyroid (6.9) and Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for KNSTRN Gene

SOURCE GeneReport for Unigene cluster for KNSTRN Gene Hs.525796

mRNA Expression by UniProt/SwissProt for KNSTRN Gene

Q9Y448-SKAP_HUMAN
Tissue specificity: Widely expressed, including in skin.
genes like me logo Genes that share expressions with KNSTRN: view

Orthologs for KNSTRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNSTRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf23 35
  • 99.47 (n)
  • 98.73 (a)
C15H15orf23 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H15orf23 35
  • 84.11 (n)
  • 78.5 (a)
C10H15ORF23 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KNSTRN 35
  • 84.94 (n)
  • 79.31 (a)
KNSTRN 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Knstrn 35
  • 76.96 (n)
  • 69.13 (a)
Knstrn 16
Knstrn 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KNSTRN 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Knstrn 35
  • 76.21 (n)
  • 66.24 (a)
chicken
(Gallus gallus)
Aves C15ORF23 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KNSTRN 36
  • 27 (a)
OneToOne
Species with no ortholog for KNSTRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KNSTRN Gene

ENSEMBL:
Gene Tree for KNSTRN (if available)
TreeFam:
Gene Tree for KNSTRN (if available)

Paralogs for KNSTRN Gene

genes like me logo Genes that share paralogs with KNSTRN: view

No data available for Paralogs for KNSTRN Gene

Variants for KNSTRN Gene

Sequence variations from dbSNP and Humsavar for KNSTRN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2289332 -- 40,391,579(-) CCTTG(C/T)GCCCT intron-variant
rs4924461 -- 40,381,505(+) agtga(A/G)ctatg upstream-variant-2KB
rs4924462 -- 40,383,494(+) GAAGG(A/G)CCATG intron-variant
rs6492943 -- 40,382,273(+) gttca(C/T)tgtct upstream-variant-2KB
rs6492944 -- 40,389,475(+) TTTTA(A/T)CTTTT intron-variant

Relevant External Links for KNSTRN Gene

HapMap Linkage Disequilibrium report
KNSTRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KNSTRN Gene

Disorders for KNSTRN Gene

UniProtKB/Swiss-Prot

SKAP_HUMAN
  • Note=Cutaneous squamous cell carcinomas (SCC): A malignancy of the skin. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Disease susceptibility is associated with variations affecting the gene represented in this entry. Variant Phe-24 appears specific for UV-associated malignancies (PubMed:25194279). {ECO:0000269 PubMed:25194279}.

No disorders were found for KNSTRN Gene.

Publications for KNSTRN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells. (PMID: 15855057) Turpaev K. … Drapier J.-C. (Free Radic. Biol. Med. 2005) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. SKAP associates with kinetochores and promotes the metaphase-to- anaphase transition. (PMID: 19667759) Fang L. … Fang G. (Cell Cycle 2009) 3 4

Products for KNSTRN Gene

Sources for KNSTRN Gene

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