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Aliases for KNOP1 Gene

Aliases for KNOP1 Gene

  • Lysine-Rich Nucleolar Protein 1 2 3
  • Testis-Specific Gene 118 Protein 3 4
  • C16orf88 3 4
  • FAM191A 3 4
  • TSG118 3 4
  • Family With Sequence Similarity 191, Member A 3
  • Family With Sequence Similarity 191 2
  • Chromosome 16 Open Reading Frame 88 2
  • Testis-Specific Gene 118 2
  • Protein C16orf88 3
  • Protein FAM191A 4
  • Member A 2
  • 101F10.1 3

External Ids for KNOP1 Gene

Previous HGNC Symbols for KNOP1 Gene

  • C16orf88

Summaries for KNOP1 Gene

GeneCards Summary for KNOP1 Gene

KNOP1 (Lysine-Rich Nucleolar Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNOP1 Gene

Genomics for KNOP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KNOP1 Gene

19,701,934 bp from pter
19,718,361 bp from pter
16,428 bases
Minus strand

Genomic View for KNOP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KNOP1 Gene

No data available for Regulatory Elements for KNOP1 Gene

Proteins for KNOP1 Gene

  • Protein details for KNOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysine-rich nucleolar protein 1
    Protein Accession:
    Secondary Accessions:
    • O43328
    • Q5FWF3

    Protein attributes for KNOP1 Gene

    458 amino acids
    Molecular mass:
    51589 Da
    Quaternary structure:
    • Interacts with ZNF106.
    • Sequence=AAC05805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH89430.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for KNOP1 Gene

Proteomics data for KNOP1 Gene at MOPED

Post-translational modifications for KNOP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KNOP1 Gene

No data available for DME Specific Peptides for KNOP1 Gene

Domains & Families for KNOP1 Gene

Protein Domains for KNOP1 Gene


Suggested Antigen Peptide Sequences for KNOP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KNOP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KNOP1 Gene

Function for KNOP1 Gene

Gene Ontology (GO) - Molecular Function for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KNOP1: view

Phenotypes for KNOP1 Gene

genes like me logo Genes that share phenotypes with KNOP1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KNOP1 Gene

Localization for KNOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNOP1 Gene

Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with KNOP1: view

No data available for Subcellular locations from COMPARTMENTS for KNOP1 Gene

Pathways & Interactions for KNOP1 Gene

SuperPathways for KNOP1 Gene

No Data Available

Interacting Proteins for KNOP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000219837 for KNOP1 Gene via STRING

Gene Ontology (GO) - Biological Process for KNOP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for KNOP1 Gene

Drugs & Compounds for KNOP1 Gene

No Compound Related Data Available

Transcripts for KNOP1 Gene

Unigene Clusters for KNOP1 Gene

Lysine-rich nucleolar protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KNOP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KNOP1 Gene

No ASD Table

Relevant External Links for KNOP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KNOP1 Gene

mRNA expression in normal human tissues for KNOP1 Gene

Protein differential expression in normal tissues from HIPED for KNOP1 Gene

This gene is overexpressed in Lung (54.3) and Fetal ovary (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for KNOP1 Gene

SOURCE GeneReport for Unigene cluster for KNOP1 Gene Hs.585209

genes like me logo Genes that share expression patterns with KNOP1: view

Protein tissue co-expression partners for KNOP1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KNOP1 Gene

Orthologs for KNOP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNOP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KNOP1 36
  • 96 (a)
C16H16orf88 35
  • 95.61 (n)
  • 93.64 (a)
(Mus musculus)
Mammalia Knop1 36
  • 55 (a)
2310008H09Rik 16
Knop1 35
  • 72.8 (n)
  • 65.02 (a)
(Monodelphis domestica)
Mammalia KNOP1 36
  • 39 (a)
(Canis familiaris)
Mammalia KNOP1 36
  • 75 (a)
KNOP1 35
  • 81.37 (n)
  • 75.83 (a)
(Bos Taurus)
Mammalia KNOP1 36
  • 75 (a)
KNOP1 35
  • 80.61 (n)
  • 74.72 (a)
(Rattus norvegicus)
Mammalia LOC680982 35
  • 66.99 (n)
  • 53.96 (a)
(Gallus gallus)
Aves KNOP1 36
  • 47 (a)
(Anolis carolinensis)
Reptilia KNOP1 36
  • 46 (a)
(Danio rerio)
Actinopterygii knop1 36
  • 25 (a)
Species with no ortholog for KNOP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNOP1 Gene

Gene Tree for KNOP1 (if available)
Gene Tree for KNOP1 (if available)

Paralogs for KNOP1 Gene

genes like me logo Genes that share paralogs with KNOP1: view

No data available for Paralogs for KNOP1 Gene

Variants for KNOP1 Gene

Sequence variations from dbSNP and Humsavar for KNOP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs720173 -- 19,710,484(-) TCTGC(A/G)AGGAG intron-variant
rs720174 -- 19,710,433(-) CATGA(A/G)GAGTG intron-variant
rs720175 -- 19,710,409(-) AAGTA(C/T)GTCCA intron-variant
rs720176 -- 19,710,193(-) GCCAG(C/T)GGTGG intron-variant
rs1016971 -- 19,707,403(-) acaac(A/T)gtgtt intron-variant

Variation tolerance for KNOP1 Gene

Residual Variation Intolerance Score: 64.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KNOP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KNOP1 Gene

Disorders for KNOP1 Gene

Relevant External Links for KNOP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KNOP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KNOP1 Gene

Publications for KNOP1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for KNOP1 Gene

Sources for KNOP1 Gene

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