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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KNOP1 Gene

protein-coding   GIFtS: 32
GCID: GC16M019714

Lysine-Rich Nucleolar Protein 1

(Previous name: chromosome 16 open reading frame 88)
(Previous symbol: C16orf88)
  Search for KNOP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysine-Rich Nucleolar Protein 11 2     Member A1
C16orf881 2 3     Testis-Specific Gene 1181
Testis-Specific Gene 118 Protein2 3     101F10.12
TSG1182 3     FAM191A2
Chromosome 16 Open Reading Frame 881     Family With Sequence Similarity 191, Member A2
Family With Sequence Similarity 1911     Protein C16orf882

External Ids:    HGNC: 344041   Entrez Gene: 4005062   Ensembl: ENSG000001035507   UniProtKB: Q1ED393   

Export aliases for KNOP1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KNOP1 Gene: 
KNOP1 (lysine-rich nucleolar protein 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KNOP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKNOP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KNOP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KNOP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

KNOP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KNOP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M019714:  view genomic region     (about GC identifiers)

Start:
19,714,902 bp from pter      End:
19,729,557 bp from pter
Size:
14,656 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KNOP1_HUMAN, Q1ED39 (See protein sequence)
Recommended Name: Lysine-rich nucleolar protein 1  
Size: 458 amino acids; 51589 Da
Subunit: Interacts with ZNF106 (By similarity)
Subcellular location: Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=AAC05805.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH89430.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: O43328 Q5FWF3

Explore the universe of human proteins at neXtProt for KNOP1: NX_Q1ED39

Explore proteomics data for KNOP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q1ED39

  • KNOP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KNOP1 Protein Expression
    REFSEQ proteins: NP_001013009.2  
    ENSEMBL proteins: 
     ENSP00000219837   ENSP00000455015   ENSP00000455369   ENSP00000454329  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    KNOP1 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q1ED39


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KNOP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KNOP1 (ENSP000002198374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KNOP1

    Search CenterWatch for drugs/clinical trials and news about KNOP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KNOP1 gene: 
    NM_001012991.2  

    Unigene Cluster for KNOP1:

    Lysine-rich nucleolar protein 1
    Hs.585209  [show with all ESTs]
    Unigene Representative Sequence: NM_001012991
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219837(uc002dgq.3) ENST00000568230 ENST00000567367 ENST00000565844
    ENST00000564480
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of KNOP1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KNOP1

    Additional mRNA sequence: 

    BC047010.1 BC089430.1 BC117562.1 

    12 DOTS entries:

    DT.100788420  DT.97787378  DT.91708212  DT.120673419  DT.120673444  DT.100001368  DT.100788418  DT.91699047 
    DT.100788421  DT.120673440  DT.40131405  DT.97765274 

    24/151 AceView cDNA sequences (see all 151):

    AW014793 BF002510 BX398547 CA867390 F34272 BU153648 AI927643 CA430737 
    BM472218 BM791473 AI918681 AI570400 BX443268 CR625565 CA312762 AI926264 
    BM822727 AA337639 AA453060 BQ052048 AI360085 BC047010 CN479616 CR594158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KNOP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KNOP1 Expression
    About this image


    See KNOP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KNOP1

    SOURCE GeneReport for Unigene cluster: Hs.585209
        SABiosciences Custom PCR Arrays for KNOP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KNOP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KNOP1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310008H09Rik1 , 5 RIKEN cDNA 2310008H09 gene1, 5 74.07(n)1
    67.04(a)1
      7 (63.66 cM)5
    663561  NM_023197.31  NP_075686.21 
     1188422375 
    chicken
    (Gallus gallus)
    Aves C16ORF886
    Uncharacterized protein
    42(a)
    1 ↔ 1
    14(14744187-14754407)
    lizard
    (Anolis carolinensis)
    Reptilia C16ORF886
    Uncharacterized protein
    46(a)
    1 ↔ 1
    GL344346.1(25611-27000)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-202h22.61 si:ch211-202h22.6 47.19(n)
    37.87(a)
      558776  XM_682043.4  XP_687135.1 


    ENSEMBL Gene Tree for KNOP1 (if available)
    TreeFam Gene Tree for KNOP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KNOP1 gene

    KNOP1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for KNOP1
    PGOHUM00000239432 PGOHUM00000251017 PGOHUM00000240640 PGOHUM00000243671 PGOHUM00000249796


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/222 SNPs in KNOP1 are shown (see all 222)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0617164
    ----see VAR_0617162 R Q mis40--------
    rs1819610111,2
    --19717263(+) CGGGAC/TTAACC 1 -- int10--------
    rs49964691,2
    C,H--19717367(+) GACTGG/TTTTAG 1 -- int14Minor allele frequency- T:0.00NS EA 412
    rs1406234181,2
    C--19717398(+) GCAGC-/TCAG  
            
    TCACA
    1 -- int10--------
    rs1442029921,2
    --19717481(+) GAAAAG/TGAGTT 1 -- int10--------
    rs47808201,2
    C,H--19717485(+) AGGAGC/TTTGCG 1 -- int113Minor allele frequency- T:0.00NA WA CSA EA 376
    rs1477602451,2
    --19717498(+) TCTCCA/GTTCCT 1 -- int10--------
    rs1426507641,2
    --19717582(+) CCCAAC/TGAGGA 1 -- int10--------
    rs1424424311,2
    --19717583(+) CCAACA/GAGGAT 1 -- int10--------
    rs1513202901,2
    --19717648(+) GCTTCA/GGGTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for KNOP1 (19714902 - 19729557 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KNOP1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KNOP1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KNOP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    2. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400506 HGNC: 34404 AceView: LOC400506 Ensembl:ENSG00000103550 euGenes: HUgn400506
    ECgene: KNOP1 H-InvDB: KNOP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KNOP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KNOP1 gene:
    Search GeneIP for patents involving KNOP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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