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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KNG1 Gene

protein-coding   GIFtS: 68
GCID: GC03P186435

kininogen 1

(Previous name: kininogen )
(Previous symbols: KNG, BDK)
 Explore 162 diseases affiliated with
KNG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KNG1    

Aliases
for KNG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kininogen 11 2     High Molecular Weight Kininogen2 3
KNG1 2 3 5     Williams-Fitzgerald-Flaujeac Factor2 3
BDK1 2 3     HMWK2 3
BK1 2     Kininogen1
Alpha-2-Thiol Proteinase Inhibitor2 3     Bradykinin1
Fitzgerald Factor2 3     Kininogen-11

External Ids:    HGNC: 63831   Entrez Gene: 38272   Ensembl: ENSG000001138897   OMIM: 6123585   UniProtKB: P010423   

Export aliases for KNG1 gene to outside databases

Previous GC identifers: GC03P187757 GC03P187917 GC03P183844


Summaries
for KNG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KNG1:
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low
molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin
system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to
HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
Function: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood
coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen
inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is
released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction,
(4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a
mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3)
release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via
bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the
aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting

summary for KNG1:
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and
pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their
action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.
Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,
smooth muscle contraction and pain.

Gene Wiki entry for KNG1 (Kininogen 1)


Genomic Views
for KNG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KNG1 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   HTF   FOXD3   HNF-3beta   AREB6   Chx10   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KNG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KNG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KNG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q21-qter

KNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KNG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186435:  view genomic region     (about GC identifiers)

Start:
 186,435,065 bp from pter      End:
 186,462,199 bp from pter
Size:
 27,135 bases      Orientation:
 plus strand

Proteins
for KNG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042 (See protein sequence)
Recommended Name: Kininogen-1 precursor  
Size: 644 amino acids; 71957 Da
Subcellular location: Secreted, extracellular space
5 PDB 3D structures from and Proteopedia for KNG1:
2WOK (3D)        4ASQ (3D)        4ASR (3D)        4ECB (3D)        4ECC (3D)    
Secondary accessions: A8K474 B2RCR2 P01043 Q53EQ0 Q6PAU9 Q7M4P1
Alternative splicing: 2 isoforms:  P01042-1   P01042-2   

Explore the universe of human proteins at neXtProt for KNG1: NX_P01042

Post-translational modifications:

  • Bradykinin is released from kininogen by plasma kallikrein1
  • Hydroxylation of Pro-383 occurs prior to the release of bradykinin1
  • Phosphorylation sites are present in the extracellular medium1
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01042

    • KNG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_000884.1  NP_001095886.1  NP_001159923.1  

    ENSEMBL proteins: 
     ENSP00000287611   ENSP00000265023   ENSP00000396025  
    Reactome Protein details: P01042
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for KNG1 (Kininogen, Kininostatin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: KNG1
    OriGene Protein Over-expression Lysate: KNG1
    OriGene Custom Protein Services for KNG1 
    GenScript Custom Purified and Recombinant Proteins Services for KNG1
    Novus Biologicals KNG1 Proteins
    Novus Biologicals KNG1 Lysates
    Sino Biological Recombinant Protein for KNG1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KNG1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0031093platelet alpha granule lumen TAS--


    KNG1 for ontologies           About GeneDecksing



    KNG1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KNG1 (Kininogen, Kininogen/Kininostatin, Kininostatin)
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    OriGene Custom Antibody Services for KNG1 
    GenScript Custom Superior Antibodies Services for KNG1
    Novus Biologicals KNG1 Antibodies
    Abcam antibodies for KNG1 
    Uscn Antibodies for KNG1
    ThermoFisher Antibody for KNG1

    Assay Products for KNG1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KNG1
    Enzo Life Sciences assays for KNG1
    Uscn ELISAs and CLIAs for KNG1

    Protein Domains /
    Families
    for KNG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KNG1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018073 Prot_inh_cystat_CS
     IPR000010 Prot_inh_cystat
     IPR002395 Kininogen

    Graphical View of Domain Structure for InterPro Entry P01042

    ProtoNet protein and cluster: P01042

    2 Blocks protein families:
    IPB000010 Cysteine protease inhibitor
    IPB002395 HMW kininogen signature


    UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
    Similarity: Contains 3 cystatin kininogen-type domains


    Function
    for KNG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
    Function: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood
    coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen
    inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is
    released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction,
    (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a
    mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3)
    release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via
    bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the
    aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): KNG1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KNG1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KNG1 (see all 10):
    hsa-miR-379 hsa-miR-361-5p hsa-miR-3655 hsa-miR-449c* hsa-miR-488 hsa-miR-3074-3p hsa-miR-578 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: KNG1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KNG1 (see all 4)
    OriGene shRNA RFP: KNG1
    OriGene siRNA: KNG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KNG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KNG1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KNG1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KNG1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): KNG1 (NM_000893)
    Sino Biological Human cDNA Clone for KNG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KNG1 

    Cell Line
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    Search LifeMap BioReagents cell lines for KNG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KNG1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0005102receptor binding IPI11290596
    GO:0005515protein binding IPI8710908
    GO:0008201heparin binding NAS12911595
    GO:0008270zinc ion binding NAS12911595


    KNG1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for KNG1:
     Decreased influenza A/WSN/33 r  Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Kng1tm1Krmc for KNG1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kng1):
     homeostasis/metabolism 

    KNG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KNG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of Fibrin Clot (Clotting Cascade)
    		Formation of Fibrin Clot (Clotting Cascade)1.00
    		Blood Coagulation Signaling Pathways0.51
    		Intrinsic Pathway0.59
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    		Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics1.00
    		ACE Inhibitor Pathway0.85
    		ACE Inhibitor Pathway, Pharmacodynamics1.00
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for KNG1
        Blood Coagulation Signaling Pathways


    4 BioSystems Pathways for KNG1 
        ACE Inhibitor Pathway
    Complement and Coagulation Cascades
    Syndecan-2-mediated signaling events
    amb2 Integrin signaling

    5/15        Reactome Pathways for KNG1 (see all 15)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Intrinsic Pathway

    2 PharmGKB Pathways for KNG1
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for KNG1):
        Complement and coagulation cascades


    KNG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KNG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/314 Interacting proteins for KNG1 (P010421, 2, 3 ENSP000002650234) via UniProtKB, MINT, STRING, and/or I2D (see all 314)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F11P039513, ENSP000002646914I2D: score=2 STRING: ENSP00000264691
    FTLP027923, ENSP000003665254I2D: score=2 STRING: ENSP00000366525
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    KLKB1P039523, ENSP000002646904I2D: score=2 STRING: ENSP00000264690
    PLAURQ034053, ENSP000003393284I2D: score=2 STRING: ENSP00000339328
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006939smooth muscle contraction TAS11385996
    GO:0006954inflammatory response TAS11385996
    GO:0007162negative regulation of cell adhesion IDA11970955
    GO:0007204elevation of cytosolic calcium ion concentration IDA16014619


    KNG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KNG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KNG1 for compounds           About GeneDecksing

    EMD Millipore small molecules for KNG1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KNG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIN 64338 hydrochlorideBradykinin B2 antagonist[151039-63-3]
    [Des-Arg9]-BradykininBradykinin receptor agonist (B1 > B2)[15958-92-6]
    Noscapine hydrochlorideTubulin inhibitor; induces apoptosis[912-60-7]
    HOE 140Potent and selective B2 antagonist[138614-30-9]
    BradykininEndogenous agonist at bradykinin receptors (B2 > B1)[6846-03-3]

    1 HMDB Compound for KNG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    10/142 Novoseek chemical compound relationships for KNG1 gene (see all 142)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kininogen 91.2 146 9576999 (4), 11156092 (2), 11237764 (2), 8388750 (2) (see all 99)
    kallidin 90.5 129 2174657 (7), 8759196 (7), 8519379 (7), 1338489 (6) (see all 62)
    icatibant 87.8 36 9139696 (3), 7833220 (3), 16226247 (2), 11104833 (2) (see all 26)
    des-arg(10)-kallidin 85.5 23 12372905 (3), 7495867 (2), 9657256 (2), 12676165 (2) (see all 18)
    histamine 82 525 8511729 (14), 9174646 (8), 9666826 (7), 8818341 (7) (see all 99)
    enalaprilat 79.5 45 18180402 (3), 10082496 (3), 17716647 (3), 12566370 (3) (see all 25)
    nitric oxide 77.7 578 11791011 (5), 8818341 (4), 9890715 (4), 19950773 (4) (see all 99)
    sodium nitroprusside 77.2 197 9797190 (5), 8698436 (4), 7615016 (3), 11356600 (3) (see all 99)
    fr190997 76.4 15 15140628 (3), 11104833 (2), 12970081 (1), 9224807 (1) (see all 6)
    fr173657 76 8 11104833 (3), 14757160 (1), 15140628 (1), 10204994 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about KNG1 

    Transcripts
    for KNG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KNG1 gene (3 alternative transcripts): 
    NM_000893.3  NM_001102416.2  NM_001166451.1  

    Unigene Cluster for KNG1:

    Kininogen 1
    Hs.77741  [show with all ESTs]
    Unigene Representative Sequence: NM_001102416
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287611(uc003fqr.3 uc021xil.1) ENST00000265023(uc011bsa.2)
    ENST00000447445

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KNG1 (see all 10):
    hsa-miR-379 hsa-miR-361-5p hsa-miR-3655 hsa-miR-449c* hsa-miR-488 hsa-miR-3074-3p hsa-miR-578 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: KNG1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KNG1 (see all 4)
    OriGene shRNA RFP: KNG1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KNG1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): KNG1 (NM_000893)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KNG1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KNG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KNG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KNG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KNG1

    Additional cDNA sequence: 

    AK223589.1 AK290839.1 AK298440.1 AK303768.1 AK315230.1 BC026253.1 BC060039.1 K02566.1 

    11 DOTS entries:

    DT.86852188  DT.95261935  DT.100829054  DT.92462290  DT.101983292  DT.304009  DT.100829050  DT.95081498 
    DT.92462321  DT.100679781  DT.95138875 

    24/169 AceView cDNA sequences (see all 169):

    CB138536 CB134907 CB146670 CB135237 CB137719 AA705692 AV647731 AI795915 
    CB148843 AI863501 CB135658 CR591010 CD014130 CB137701 CB135222 AI913254 
    AV647431 CB135794 AI625797 CR590668 CB122248 CB138487 CB147381 AV655954 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KNG1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                              -                                       
    SP2:                                                  -           -                                       
    SP3:                                -     -                                                               


    ECgene alternative splicing isoforms for KNG1

    Expression
    for KNG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KNG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCCAAGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KNG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KNG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KNG1

    SOURCE GeneReport for Unigene cluster: Hs.77741

    UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
    Tissue specificity: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not
    in benign tumors

        SABiosciences Expression via Pathway-Focused PCR Arrays including KNG1: 
              Hypertension in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for KNG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KNG1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kng11 , 5 kininogen 11, 5 72.58(n)1
    60.6(a)1    		   16 (13.88 cM)5
    166441  NM_001102411.11  NP_001095881.11 
     230578655 
    chicken
    (Gallus gallus)    		 Aves KNG11 kininogen 1 53.21(n)
    39.64(a)    		   424957  XM_422766.3  XP_422766.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KNG16
    		 --
    		 36(a)
    		 1 ↔ 1
    		 GL343321.1(150756-173818)
    zebrafish
    (Danio rerio)    		 Actinopterygii kng16
    		 kininogen 1
    		 21(a)
    		 1 ↔ 1
    		 22(39721702-39758755)


    ENSEMBL Gene Tree for KNG1 (if available)
    TreeFam Gene Tree for KNG1 (if available) 

    Paralogs
    for KNG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for KNG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
    Polymorphism: The T-kinin peptide is missing residues 378 to 380, probably as a result of a naturally occurring
    variant. The complete sequence of the T-kinin peptide is therefore ISRPPGFSPFR. This peptide is associated with
    malignant tumors but not with benign ones


    10/749 NCBI SNPs in KNG1 are shown (see all 749)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119243901,2
    		C,F,H,--186433099(+) TCACAT/CAAAAA 3 -- us2k114Minor allele frequency- C:0.39EA NS NA WA CSA 678
    rs1835442491,2
    		--186433140(+) AATACA/GATTTG 3 -- us2k10--------
    rs1504767811,2
    		--186433148(+) TTGGCA/GGAAAA 3 -- us2k10--------
    rs1888730541,2
    		--186433152(+) CAGAAA/GAGTAA 3 -- us2k10--------
    rs1922093841,2
    		--186433259(+) TTAGAC/TATAGC 3 -- us2k10--------
    rs1824213211,2
    		--186433345(+) AGTTCA/GAGACC 3 -- us2k10--------
    rs1385225201,2
    		--186433372(+) TGAAAC/TCTCGT 3 -- us2k10--------
    rs1427061381,2
    		--186433384(+) TCTTCC/TAAAAA 3 -- us2k10--------
    rs622926411,2
    		C,--186433418(+) GGCAGA/TCCCCT 3 -- us2k13Minor allele frequency- T:0.17WA NA 6
    rs37742911,2
    		C,F,A,H,--186433471(+) TAACCC/TGGGAA 3 -- us2k19Minor allele frequency- T:0.41EA NS WA NA 550

    HapMap Linkage Disequilibrium report for KNG1 (186435065 - 186462199 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for KNG1
         2 CNVs: 47856 3467
    Human Gene Mutation Database (HGMD): KNG1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KNG1
    DNA2.0 Custom Variant and Variant Library Synthesis for KNG1

    Disorders / Diseases
    for KNG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KNG1 for disorders           About GeneDecksing

    OMIM gene information: 612358   
    OMIM disorders: 228960  
    UniProtKB/Swiss-Prot: KNG1_HUMAN, P01042
  • Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) [MIM:228960].
    • HMWK deficiency is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic
    tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis

    20/162 diseases for KNG1 (see all 162):    About MalaCards
    high-molecular-weight kininogen deficiency    plasminogen activator inhibitor type 1 deficiency    kininogen deficiency    pre-eclampsia
    factor xii deficiency    severe pre-eclampsia    aortic valve stenosis    brain edema
    interleukin receptor    angioedema    back pain    pulpitis
    allergic rhinitis    type 2 diabetes mellitus    type 1 diabetes mellitus    myocardial infarction
    congestive heart failure    proliferative vitreoretinopathy    otitis media    rhinitis

    18 diseases from the University of Copenhagen DISEASES database for KNG1:
    Urticaria     Hypertension     Heart disease     C1 inhibitor deficiency
    Pleurisy     Asthma     Neuroblastoma     Atherosclerosis
    Kidney disease     Diabetes mellitus     Malignant glioma     Rhinitis
    Pancreatitis     Pain agnosia     Brain edema     Cerebrovascular accident
    Gastrointestinal system disease     Arthritis

    10/94 Novoseek disease relationships for KNG1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angioedema 80.9 113 12639808 (7), 2185292 (3), 9530537 (3), 12222554 (2) (see all 59)
    angioedema, hereditary 79.5 25 18220146 (2), 17418383 (2), 20377108 (2), 18814451 (2) (see all 19)
    anaphylactoid reaction 66 17 8268545 (3), 8141183 (3), 7623993 (2), 2266684 (1) (see all 11)
    inflammation 59.1 144 8542147 (3), 18783336 (3), 11471646 (2), 8648021 (2) (see all 99)
    venous occlusion 59.1 25 10927043 (2), 9336392 (1), 11196511 (1), 7505360 (1) (see all 24)
    heart failure 54.8 45 18798730 (4), 11684627 (4), 10411851 (3), 10489393 (3) (see all 24)
    hyperalgesia 53.3 40 1752117 (6), 1491860 (5), 10422653 (4), 10640624 (4) (see all 24)
    essential hypertension 48.6 17 19289643 (2), 11355044 (2), 8562274 (1), 10560792 (1) (see all 13)
    cardiovascular diseases 47.3 17 11975815 (3), 17212359 (1), 16023651 (1), 10952948 (1) (see all 15)
    asthma 46.3 94 9762778 (4), 1970226 (3), 7597662 (3), 2127257 (2) (see all 62)

    Human Genome Epidemiology (HuGE) Navigator: KNG1 (13 documents)

    Export disorders for KNG1 gene to outside databases

    Publications
    for KNG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KNG1 gene, integrated from 9 sources (see all 2273):
    (articles sorted by number of sources associating them with KNG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping of human kininogen gene (KNG) to 3q26----qter. (PubMed id 1733668)1, 3, 9 Cheung P.P....Colman R.W. (1992)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    5. Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage. (PubMed id 7589467)1, 2 Straczek J.... Belleville F. (1995)
    6. Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer. (PubMed id 3182782)1, 2 Maeda H.... Kato H. (1988)
    7. Isolation and identification of hydroxyproline analogues of bradykinin in human urine. (PubMed id 3366244)1, 2 Kato H.... Maeda H. (1988)
    8. Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication. (PubMed id 3484703)1, 2 Kellermann J.... Muller-Esterl W. (1986)
    9. Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens. (PubMed id 2989293)1, 2 Takagaki Y.... Nakanishi S. (1985)
    10. The amino acid sequence of the light chain of human high-molecular- mass kininogen. (PubMed id 4054110)1, 2 Lottspeich F....Mueller-Esterl W. (1985)

    External Searches for KNG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KNG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3827 HGNC: 6383 AceView: KNG1 Ensembl:ENSG00000113889 euGenes: HUgn3827
    ECgene: KNG1 Kegg: 3827 H-InvDB: KNG1

    Other Databases showing KNG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KNG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KNG1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/High-molecular_weight_kininogen
    SeattleSNPshttp://pga.gs.washington.edu/data/kng/

    Intellectual Property
    for KNG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KNG1 gene:
    Search GeneIP for patents involving KNG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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