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Aliases for KNDC1 Gene

Aliases for KNDC1 Gene

  • Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 2 3
  • Kinase Non-Catalytic C-Lobe Domain-Containing Protein 1 3 4
  • Ras-GEF Domain-Containing Family Member 2 3 4
  • KIND Domain-Containing Protein 1 3 4
  • RasGEF Domain Family, Member 2 2 3
  • Cerebral Protein 9 3 4
  • C10orf23 3 4
  • RASGEF2 3 4
  • Protein Very KIND 3
  • BB439H18.3 3
  • KIAA1768 4
  • VKIND 4

External Ids for KNDC1 Gene

Previous HGNC Symbols for KNDC1 Gene

  • RASGEF2
  • C10orf23

Previous GeneCards Identifiers for KNDC1 Gene

  • GC10P134448
  • GC10P134862
  • GC10P134974
  • GC10P128521

Summaries for KNDC1 Gene

GeneCards Summary for KNDC1 Gene

KNDC1 (Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and Ras guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for KNDC1 Gene

  • Probable guanine nucleotide exchange factor (GEF)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNDC1 Gene

Genomics for KNDC1 Gene

Regulatory Elements for KNDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KNDC1 Gene

Start:
133,160,447 bp from pter
End:
133,226,412 bp from pter
Size:
65,966 bases
Orientation:
Plus strand

Genomic View for KNDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNDC1 Gene

Proteins for KNDC1 Gene

  • Protein details for KNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76NI1-VKIND_HUMAN
    Recommended name:
    Protein very KIND
    Protein Accession:
    Q76NI1
    Secondary Accessions:
    • B0QZC5
    • Q5T233
    • Q6ZNH8
    • Q8TEE5
    • Q96LV7
    • Q9C095

    Protein attributes for KNDC1 Gene

    Size:
    1749 amino acids
    Molecular mass:
    191397 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21859.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI17339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KNDC1 Gene

neXtProt entry for KNDC1 Gene

Proteomics data for KNDC1 Gene at MOPED

Post-translational modifications for KNDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KNDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KNDC1 Gene

Domains for KNDC1 Gene

Suggested Antigen Peptide Sequences for KNDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q76NI1

UniProtKB/Swiss-Prot:

VKIND_HUMAN :
  • Q76NI1
Domain:
  • Contains 2 KIND domains.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with KNDC1: view

No data available for Gene Families for KNDC1 Gene

Function for KNDC1 Gene

Molecular function for KNDC1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF)

Gene Ontology (GO) - Molecular Function for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
genes like me logo Genes that share ontologies with KNDC1: view

Phenotypes for KNDC1 Gene

MGI mutant phenotypes for KNDC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for KNDC1:
genes like me logo Genes that share phenotypes with KNDC1: view

Animal Models for KNDC1 Gene

MGI Knock Outs for KNDC1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KNDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KNDC1 Gene

Localization for KNDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KNDC1 Gene COMPARTMENTS Subcellular localization image for KNDC1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0030425 dendrite IEA --
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KNDC1 Gene

Pathways for KNDC1 Gene

SuperPathways for KNDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0021707 cerebellar granule cell differentiation IEA --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Pathways by source for KNDC1 Gene

Compounds for KNDC1 Gene

(3) HMDB Compounds for KNDC1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with KNDC1: view

Transcripts for KNDC1 Gene

Unigene Clusters for KNDC1 Gene

Kinase non-catalytic C-lobe domain (KIND) containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KNDC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KNDC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - - - -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for KNDC1 Gene

GeneLoc Exon Structure for
KNDC1
ECgene alternative splicing isoforms for
KNDC1

Expression for KNDC1 Gene

mRNA expression in normal human tissues for KNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for KNDC1 Gene

This gene is overexpressed in Brain - Cortex (5.4), Brain - Cerebellum (5.2), Brain - Cerebellar Hemisphere (4.9), Brain - Frontal Cortex (BA9) (4.2), and Pituitary (4.1).

Protein differential expression in normal tissues for KNDC1 Gene

This gene is overexpressed in Stomach (57.0) and Heart (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KNDC1 Gene

SOURCE GeneReport for Unigene cluster for KNDC1 Gene Hs.530685

mRNA Expression by UniProt/SwissProt for KNDC1 Gene

Q76NI1-VKIND_HUMAN
Tissue specificity: Expressed specifically in the cerebral cortex.
genes like me logo Genes that share expressions with KNDC1: view

Expression partners for KNDC1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KNDC1 Gene

Orthologs for KNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Kndc1 35
  • 78.7 (n)
  • 78.54 (a)
Kndc1 16
Kndc1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kndc1 35
  • 77.29 (n)
  • 75.89 (a)
cow
(Bos Taurus)
Mammalia KNDC1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KNDC1 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KNDC1 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves KNDC1 35
  • 58.39 (n)
  • 57.95 (a)
KNDC1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KNDC1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kndc1 35
  • 60.6 (n)
  • 58.23 (a)
zebrafish
(Danio rerio)
Actinopterygii KNDC1 (1 of 2) 36
  • 43 (a)
OneToMany
KNDC1 (2 of 2) 36
  • 32 (a)
OneToMany
Species with no ortholog for KNDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNDC1 Gene

ENSEMBL:
Gene Tree for KNDC1 (if available)
TreeFam:
Gene Tree for KNDC1 (if available)

Paralogs for KNDC1 Gene

Selected SIMAP similar genes for KNDC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KNDC1 Gene

genes like me logo Genes that share paralogs with KNDC1: view

No data available for Paralogs for KNDC1 Gene

Variants for KNDC1 Gene

Sequence variations from dbSNP and Humsavar for KNDC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12028 -- 133,207,331(+) GGGCT(C/G)ATGGC reference, synonymous-codon
rs1129334 -- 133,210,707(-) CTGTT(A/G)ATGCG reference, synonymous-codon
rs2998115 -- 133,226,651(-) GGCGG(C/T)AGCTT downstream-variant-500B
rs2998116 -- 133,224,406(-) GGCTC(C/G)TCCCT intron-variant
rs2998117 -- 133,224,263(-) CCAGG(A/G)CCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KNDC1 Gene

Variant ID Type Subtype PubMed ID
dgv851n71 CNV Loss 21882294
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
dgv875n71 CNV Loss 21882294
nsv896257 CNV Gain 21882294
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv7630 CNV Loss 18451855
nsv832038 CNV Gain+Loss 17160897
nsv896265 CNV Gain 21882294
dgv878n71 CNV Loss 21882294
nsv896267 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
esv2743835 CNV Deletion 23290073
esv2151232 CNV Deletion 18987734
esv999631 CNV Deletion 20482838
esv1050169 CNV Deletion 17803354
dgv180e199 CNV Deletion 23128226
esv2743836 CNV Deletion 23290073
esv26610 CNV Gain 19812545
esv2657046 CNV Deletion 23128226
dgv881n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
esv2743837 CNV Deletion 23290073
esv2743838 CNV Deletion 23290073
esv1549920 CNV Deletion 17803354
esv2743839 CNV Deletion 23290073
essv9566 CNV CNV 17122850
esv2743840 CNV Deletion 23290073
nsv8750 CNV Gain+Loss 18304495
esv3360 CNV Deletion 18987735
esv2583286 CNV Deletion 19546169
nsv512194 CNV Loss 21212237
esv2674165 CNV Deletion 23128226
esv1976405 CNV Deletion 18987734
esv22327 CNV Loss 19812545
esv2668433 CNV Deletion 23128226
esv1106376 CNV Deletion 17803354
esv1090620 CNV Deletion 17803354
dgv883n71 CNV Loss 21882294
esv1213053 CNV Insertion 17803354
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294

Relevant External Links for KNDC1 Gene

HapMap Linkage Disequilibrium report
KNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KNDC1 Gene

Disorders for KNDC1 Gene

Relevant External Links for KNDC1

Genetic Association Database (GAD)
KNDC1
Human Genome Epidemiology (HuGE) Navigator
KNDC1

No disorders were found for KNDC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KNDC1 Gene

Publications for KNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Proteomic profiling of Myc-associated proteins. (PMID: 21150319) Agrawal P. … Sedivy J.M. (Cell Cycle 2010) 3

Products for KNDC1 Gene

Sources for KNDC1 Gene

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