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Aliases for KNDC1 Gene

Aliases for KNDC1 Gene

  • Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 2 3 5
  • Kinase Non-Catalytic C-Lobe Domain-Containing Protein 1 3 4
  • Ras-GEF Domain-Containing Family Member 2 3 4
  • KIND Domain-Containing Protein 1 3 4
  • RasGEF Domain Family, Member 2 2 3
  • Cerebral Protein 9 3 4
  • C10orf23 3 4
  • RASGEF2 3 4
  • BB439H18.3 3
  • KIAA1768 4
  • VKIND 4

External Ids for KNDC1 Gene

Previous HGNC Symbols for KNDC1 Gene

  • RASGEF2
  • C10orf23

Previous GeneCards Identifiers for KNDC1 Gene

  • GC10P134448
  • GC10P134862
  • GC10P134974
  • GC10P128521

Summaries for KNDC1 Gene

GeneCards Summary for KNDC1 Gene

KNDC1 (Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and Ras guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for KNDC1 Gene

  • Probable guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNDC1 Gene

Genomics for KNDC1 Gene

Regulatory Elements for KNDC1 Gene

Promoters for KNDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KNDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KNDC1 Gene

Chromosome:
10
Start:
133,160,447 bp from pter
End:
133,226,412 bp from pter
Size:
65,966 bases
Orientation:
Plus strand

Genomic View for KNDC1 Gene

Genes around KNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNDC1 Gene

Proteins for KNDC1 Gene

  • Protein details for KNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76NI1-VKIND_HUMAN
    Recommended name:
    Protein very KIND
    Protein Accession:
    Q76NI1
    Secondary Accessions:
    • B0QZC5
    • Q5T233
    • Q6ZNH8
    • Q8TEE5
    • Q96LV7
    • Q9C095

    Protein attributes for KNDC1 Gene

    Size:
    1749 amino acids
    Molecular mass:
    191397 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21859.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI17339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KNDC1 Gene

neXtProt entry for KNDC1 Gene

Proteomics data for KNDC1 Gene at MOPED

Post-translational modifications for KNDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KNDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KNDC1 Gene

Domains & Families for KNDC1 Gene

Suggested Antigen Peptide Sequences for KNDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q76NI1

UniProtKB/Swiss-Prot:

VKIND_HUMAN :
  • Contains 2 KIND domains.
Domain:
  • Contains 2 KIND domains.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with KNDC1: view

No data available for Gene Families for KNDC1 Gene

Function for KNDC1 Gene

Molecular function for KNDC1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF).
genes like me logo Genes that share phenotypes with KNDC1: view

Animal Models for KNDC1 Gene

MGI Knock Outs for KNDC1:

Animal Model Products

miRNA for KNDC1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KNDC1 Gene

Localization for KNDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KNDC1 Gene COMPARTMENTS Subcellular localization image for KNDC1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KNDC1 Gene

Pathways & Interactions for KNDC1 Gene

SuperPathways for KNDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008150 biological_process ND --
GO:0048814 regulation of dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Pathways by source and SIGNOR curated interactions for KNDC1 Gene

Drugs & Compounds for KNDC1 Gene

(3) Drugs for KNDC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KNDC1: view

Transcripts for KNDC1 Gene

Unigene Clusters for KNDC1 Gene

Kinase non-catalytic C-lobe domain (KIND) containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KNDC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - - - -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for KNDC1 Gene

GeneLoc Exon Structure for
KNDC1
ECgene alternative splicing isoforms for
KNDC1

Expression for KNDC1 Gene

mRNA expression in normal human tissues for KNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for KNDC1 Gene

This gene is overexpressed in Brain - Cortex (x5.4), Brain - Cerebellum (x5.2), Brain - Cerebellar Hemisphere (x4.9), Brain - Frontal Cortex (BA9) (x4.2), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for KNDC1 Gene

This gene is overexpressed in Stomach (57.0) and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KNDC1 Gene



SOURCE GeneReport for Unigene cluster for KNDC1 Gene Hs.530685

mRNA Expression by UniProt/SwissProt for KNDC1 Gene

Q76NI1-VKIND_HUMAN
Tissue specificity: Expressed specifically in the cerebral cortex.
genes like me logo Genes that share expression patterns with KNDC1: view

Protein tissue co-expression partners for KNDC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KNDC1 Gene

Orthologs for KNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KNDC1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KNDC1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KNDC1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kndc1 16
Kndc1 36
  • 76 (a)
OneToOne
Kndc1 35
  • 78.7 (n)
  • 78.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kndc1 35
  • 77.29 (n)
  • 75.89 (a)
chicken
(Gallus gallus)
Aves KNDC1 35
  • 58.39 (n)
  • 57.95 (a)
KNDC1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KNDC1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kndc1 35
  • 60.6 (n)
  • 58.23 (a)
zebrafish
(Danio rerio)
Actinopterygii KNDC1 (1 of 2) 36
  • 43 (a)
OneToMany
KNDC1 (2 of 2) 36
  • 32 (a)
OneToMany
Species with no ortholog for KNDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNDC1 Gene

ENSEMBL:
Gene Tree for KNDC1 (if available)
TreeFam:
Gene Tree for KNDC1 (if available)

Paralogs for KNDC1 Gene

(1) SIMAP similar genes for KNDC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KNDC1 Gene

genes like me logo Genes that share paralogs with KNDC1: view

No data available for Paralogs for KNDC1 Gene

Variants for KNDC1 Gene

Sequence variations from dbSNP and Humsavar for KNDC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3810964 - 133,186,655(-) CACTT(C/T)CCAGC reference, missense
VAR_035359 -
rs2998139 - 133,198,658(-) CCTCC(A/G)GGGAG reference, missense
VAR_051902 -
rs35604376 - 133,201,623(+) CTCAG(A/T)GGTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KNDC1 Gene

Variant ID Type Subtype PubMed ID
dgv851n71 CNV Loss 21882294
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
dgv875n71 CNV Loss 21882294
nsv896257 CNV Gain 21882294
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv7630 CNV Loss 18451855
nsv832038 CNV Gain+Loss 17160897
nsv896265 CNV Gain 21882294
dgv878n71 CNV Loss 21882294
nsv896267 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
esv2743835 CNV Deletion 23290073
esv2151232 CNV Deletion 18987734
esv999631 CNV Deletion 20482838
esv1050169 CNV Deletion 17803354
dgv180e199 CNV Deletion 23128226
esv2743836 CNV Deletion 23290073
esv26610 CNV Gain 19812545
esv2657046 CNV Deletion 23128226
dgv881n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
esv2743837 CNV Deletion 23290073
esv2743838 CNV Deletion 23290073
esv1549920 CNV Deletion 17803354
esv2743839 CNV Deletion 23290073
essv9566 CNV CNV 17122850
esv2743840 CNV Deletion 23290073
nsv8750 CNV Gain+Loss 18304495
esv3360 CNV Deletion 18987735
esv2583286 CNV Deletion 19546169
nsv512194 CNV Loss 21212237
esv2674165 CNV Deletion 23128226
esv1976405 CNV Deletion 18987734
esv22327 CNV Loss 19812545
esv2668433 CNV Deletion 23128226
esv1106376 CNV Deletion 17803354
esv1090620 CNV Deletion 17803354
dgv883n71 CNV Loss 21882294
esv1213053 CNV Insertion 17803354
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294

Variation tolerance for KNDC1 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KNDC1 Gene

HapMap Linkage Disequilibrium report
KNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KNDC1 Gene

Disorders for KNDC1 Gene

Relevant External Links for KNDC1

Genetic Association Database (GAD)
KNDC1
Human Genome Epidemiology (HuGE) Navigator
KNDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KNDC1

No disorders were found for KNDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KNDC1 Gene

Publications for KNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. KNDC1 knockdown protects human umbilical vein endothelial cells from senescence. (PMID: 24788352) Zhang C. … Hu G. (Mol Med Rep 2014) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Proteomic profiling of Myc-associated proteins. (PMID: 21150319) Agrawal P. … Sedivy J.M. (Cell Cycle 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KNDC1 Gene

Sources for KNDC1 Gene

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