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Aliases for KNCN Gene

Aliases for KNCN Gene

  • Kinocilin 2 3
  • Kino 3 6
  • L5 3 6

External Ids for KNCN Gene

Previous GeneCards Identifiers for KNCN Gene

  • GC01M046783
  • GC01M047011
  • GC01M045127

Summaries for KNCN Gene

GeneCards Summary for KNCN Gene

KNCN (Kinocilin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KNCN Gene

  • May play a role in stabilizing dense microtubular networks or in vesicular trafficking.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNCN Gene

Genomics for KNCN Gene

Regulatory Elements for KNCN Gene

Genomic Location for KNCN Gene

Start:
46,545,644 bp from pter
End:
46,551,527 bp from pter
Size:
5,884 bases
Orientation:
Minus strand

Genomic View for KNCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KNCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNCN Gene

Proteins for KNCN Gene

  • Protein details for KNCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVL3-KNCN_HUMAN
    Recommended name:
    Kinocilin
    Protein Accession:
    A6PVL3
    Secondary Accessions:
    • A8MXE3

    Protein attributes for KNCN Gene

    Size:
    124 amino acids
    Molecular mass:
    12832 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KNCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KNCN Gene

Proteomics data for KNCN Gene at MOPED

Post-translational modifications for KNCN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KNCN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KNCN Gene

Domains for KNCN Gene

Protein Domains for KNCN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KNCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KNCN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KNCN Gene

Function for KNCN Gene

Molecular function for KNCN Gene

UniProtKB/Swiss-Prot Function: May play a role in stabilizing dense microtubular networks or in vesicular trafficking.

miRNA for KNCN Gene

miRTarBase miRNAs that target KNCN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KNCN Gene

Localization for KNCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNCN Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KNCN Gene COMPARTMENTS Subcellular localization image for KNCN gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KNCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0015630 microtubule cytoskeleton --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0032437 cuticular plate IEA --
genes like me logo Genes that share ontologies with KNCN: view

Pathways for KNCN Gene

SuperPathways for KNCN Gene

No Data Available

Interacting Proteins for KNCN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379607%0d%0a9606.ENSP00000389140%0d%0a
Selected Interacting proteins: ENSP00000379607 for KNCN Gene via STRING

Symbol External ID(s) Details
DCC

Gene Ontology (GO) - Biological Process for KNCN Gene

None

No data available for Pathways by source for KNCN Gene

Transcripts for KNCN Gene

mRNA/cDNA for KNCN Gene

(5) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KNCN Gene

Kinocilin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KNCN Gene

No ASD Table

Relevant External Links for KNCN Gene

GeneLoc Exon Structure for
KNCN
ECgene alternative splicing isoforms for
KNCN

Expression for KNCN Gene

mRNA expression in normal human tissues for KNCN Gene

mRNA differential expression in normal tissues according to GTEx for KNCN Gene

This gene is overexpressed in Brain - Hypothalamus (7.5), Brain - Nucleus accumbens (basal ganglia) (7.1), and Testis (7.0).

SOURCE GeneReport for Unigene cluster for KNCN Gene Hs.350764

genes like me logo Genes that share expressions with KNCN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KNCN Gene

Orthologs for KNCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KNCN 35
  • 99.01 (n)
  • 98.02 (a)
KNCN 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KNCN 35
  • 88.67 (n)
  • 88 (a)
KNCN 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KNCN 35
  • 85.33 (n)
  • 90 (a)
KNCN 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kncn 35
  • 83.33 (n)
  • 82 (a)
Kncn 16
Kncn 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kncn 35
  • 82 (n)
  • 82 (a)
zebrafish
(Danio rerio)
Actinopterygii KNCN 36
  • 10 (a)
OneToOne
Species with no ortholog for KNCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNCN Gene

ENSEMBL:
Gene Tree for KNCN (if available)
TreeFam:
Gene Tree for KNCN (if available)

Paralogs for KNCN Gene

No data available for Paralogs for KNCN Gene

Variants for KNCN Gene

Structural Variations from Database of Genomic Variants (DGV) for KNCN Gene

Variant ID Type Subtype PubMed ID
nsv755 CNV Insertion 18451855

Relevant External Links for KNCN Gene

HapMap Linkage Disequilibrium report
KNCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KNCN Gene

Disorders for KNCN Gene

No disorders were found for KNCN Gene.

No data available for UniProtKB/Swiss-Prot for KNCN Gene

Publications for KNCN Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Initial characterization of kinocilin, a protein of the hair cell kinocilium. (PMID: 15855039) Leibovici M. … Petit C. (Hear. Res. 2005) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KNCN Gene

Sources for KNCN Gene

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